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JOURNAL ARTICLE
Sara Ferrigno, Paola Conigliaro, Stefano Rizza, Susanna Longo, Carolina Nesi, Federico Carlucci, Alberto Bergamini, Raffaele Mancino, Carlo Nucci, Massimo Federici, Maria Sole Chimenti, Massimo Cesareo
OBJECTIVES: Patients with SLE have higher cardiovascular (CV) risk compared with healthy controls (HC) and are characterised by accelerated atherosclerosis; intima media thickness (IMT), marker of subclinical atherosclerosis, is higher in patients with SLE than in HCs. Retinal microvascular impairment detected through optical coherence tomography angiography (OCTA) was investigated as a marker of systemic vascular involvement in SLE.The aim of the study was to evaluate the relationship between retinal vascular impairment and IMT in SLE...
October 2023: Lupus Science & Medicine
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JOURNAL ARTICLE
Ali Amr, Jan Koelemen, Christoph Reich, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Jan Haas, Karen Frese, David Lehmann, Hugo A Katus, Norbert Frey, Benjamin Meder
BACKGROUND AND AIMS: The cardiac societies of Europe and the United States have established different risk models for preventing sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). The aim of this study is to validate current SCD risk prediction methods in a German HCM cohort and to improve them by the addition of genotype information. METHODS: HCM patients without prior SCD or equivalent arrhythmic events ≥ 18 years of age were enrolled in an expert cardiomyopathy center in Germany...
October 4, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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JOURNAL ARTICLE
Jose A Plaza, Liubov Kastnerova, Alejandro A Gru, Brittany Dulmage, Martin J Sangueza, Dmitry V Kazakov
Spiradenomas are benign cutaneous adnexal neoplasms with sweat gland differentiation that can manifest a broad spectrum of histomorphologic appearances. While they show a characteristic histopathologic phenotype and clinical management involves surgical excision with a low risk of recurrence, there have been unusual histopathologic variants of spiradenoma reported, including cases with adenoid cystic carcinoma (ACC)-like changes. Primary cutaneous ACC is a low-grade malignancy presenting as a subcutaneous mass with the potential for local invasion, perineural invasion, and high rates of local recurrence after excision...
September 22, 2023: American Journal of Surgical Pathology
#24
JOURNAL ARTICLE
Heena Doshi, Katrin Spengler, Amod Godbole, Yi Sing Gee, Jonathan Baell, Jonathan S Oakhill, Andreas Henke, Regine Heller
Herpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may trigger an innate immune response and induce damage of organs. In these conditions, HSV-1 may infect vascular endothelial cells, but little is known about the regulation of HSV-1 replication and possible defense mechanisms in these cells. The current study addresses the question of whether the host cell protein AMP-activated protein kinase (AMPK), an important metabolic sensor, can control HSV-1 replication in endothelial cells...
September 13, 2023: Microbiology Spectrum
#25
JOURNAL ARTICLE
Glenn J Hanna, Myung-Ju Ahn, Jameel Muzaffar, Bhumsuk Keam, Daniel W Bowles, Deborah J Wong, Alan L Ho, Sung-Bae Kim, Francis Worden, Tak Yun, Xianzhang Meng, Jan M Van Tornout, Maureen G Conlan, Hyunseok Kang
PURPOSE: This open-label, single-arm, phase 2 study evaluated the vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase inhibitor (TKI) rivoceranib in patients with recurrent or metastatic (R/M) adenoid cystic carcinoma (ACC). PATIENTS AND METHODS: Eligible patients had confirmed disease progression per Response Evaluation Criteria in Solid Tumors (RECIST) with ≥20% increase in radiologically or clinically measurable lesions or appearance of new lesions within the preceding 6 months...
August 29, 2023: Clinical Cancer Research
#26
JOURNAL ARTICLE
Khalil Ur Rahman, Kashmala Ali, Mamoona Rauf, Muhammad Arif
Transient and prolonged waterlogging stress (WS) stimulates ethylene (ET) generation in plants, but their reprogramming is critical in determining the plants' fate under WS, which can be combated by the application of symbiotically associated beneficial microbes that induce resistance to WS. The present research was rationalized to explore the potential of the newly isolated 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase-producing fungal endophytic consortium of Aspergillus nomiae (MA1) and Aspergillus fumigatus (MA4) on maize growth promotion under WS...
August 7, 2023: Microorganisms
#27
JOURNAL ARTICLE
Lara Hamzehpour, Tamara Bohn, Lucia Jaspers, Oliver Grimm
Decreased physical fitness and being overweight are highly prevalent in schizophrenia, represent a major risk factor for comorbid cardio-vascular diseases and decrease the life expectancy of the patients. Thus, it is important to understand the underlying mechanisms that link psychopathology and weight gain. We hypothesize that the dopaminergic reward system plays an important role in this. We analyzed the seed-based functional connectivity (FC) of the ventral tegmental area (VTA) in a group of schizophrenic patients (n=32) and age-, as well as gender-, matched healthy controls (n=27)...
August 8, 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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JOURNAL ARTICLE
Caner Topaloglu, Sinan Bilgin
BACKGROUND: The aim of this study was to assess retinal vessel density in the superficial capillary plexus layer, deep capillary plexus layer and choriocapillaris plexus layer in patients with aortic valve regurgitation (AR) using optical coherence tomography angiography (OCTA). METHODS: Thirty-eight healthy participants (group 1) and 38 patients with AR (group 2) were assessed for this study. Diagnosis of AR is made by transthoracic echocardiography (TTE). Severity of AR was assessed according to values in the 2014 American Heart Association/American College of Cardiology (AHA/ACC) valve guideline...
August 2023: Cardiology Research
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JOURNAL ARTICLE
Jaciara Tiago Antunes Alvarenga, Adriana Cristina Nicolussi, Aline Maria Pereira Cruz Ramos, Lucas Fernando Antunes Gomes, Damiana Aparecida Trindade Monteiro, Silmara Elaine Malaguti Toffano
OBJECTIVES: to analyze the knowledge and experience of undergraduate nursing students regarding infusion therapy and peripheral vascular access. METHODS: descriptive, cross-sectional, analytical study with 123 undergraduate nursing students who answered a semi-structured instrument. RESULTS: the majority were women, with a median age of 51 years old; 87% considered the teaching received insufficient to perform in clinical practice. The mean overall knowledge score was 78...
2023: Revista Brasileira de Enfermagem
#30
REVIEW
Muhammad Abubakar, Izzah Javed, Hafiz Fahad Rasool, Saud Raza, Deepak Basavaraju, Rai Muhammad Abdullah, Faizan Ahmed, Siffat S Salim, Muhammad Ahmad Faraz, Khawaja Mushammar Hassan, Mohsin Hajjaj
Percutaneous coronary intervention (PCI) is a widely used therapy for coronary artery disease (CAD), but it carries risks and complications. Adhering to evidence-based practice guidelines is crucial for optimal outcomes. This review compares the recommendations of the 2021 American College of Cardiology/American Heart Association/Society for Cardiovascular Angiography and Interventions (ACC/AHA/SCAI) and 2018 European Society of Cardiology (ESC) guidelines for coronary artery revascularization and discusses emerging trends and novel devices in PCI...
July 2023: Curēus
#31
REVIEW
Ante Rotim, Vladimir Kalousek, Marina Raguž, Darko Orešković, Filip Vrban, Ivan Brumini, Krešimir Rotim
Carotid-cavernous fistula (CCF) is a relatively rare pathology with a low incidence compared with other vascular pathologies. They can be classified based on hemodynamics as low- or high-flow fistulas, and anatomically as direct or indirect fistulas. Anatomy of the shunt somewhat dictates the selection of endovascular treatment, meaning the venous or arterial approach and selection of embolizing materials. Although there is general agreement as to when to access CCF transvenously or transarterialy, which depends on the shunt being direct or indirect, there is no uniform agreement on which occlusion method should be used...
November 2022: Acta Clinica Croatica
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JOURNAL ARTICLE
Marcel Mayer, Lisa Nachtsheim, Johanna Prinz, Sami Shabli, Malte Suchan, Jens Peter Klußmann, Alexander Quaas, Christoph Arolt, Philipp Wolber
Many locally advanced and metastatic salivary gland carcinomas (SGC) lack therapeutic targets. Enfortumab vedotin, an antibody-drug conjugate binding to Nectin-4, recently gained FDA approval for third-line urothelial carcinoma. Therefore, the aim of this study was to assess the expression of Nectin-4 in primary SGC and corresponding lymph node metastases and to correlate it with clinicopathological data. Immunohistochemical staining for Nectin-4 was performed for patients who had undergone surgery with curative intent for primary SGC of the parotid or submandibular gland in a tertiary referral center between 1990 and 2019...
July 22, 2023: Clinical & Experimental Metastasis
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JOURNAL ARTICLE
Maribel Gonzalez-Del-Hoyo, Caterina Mas-Llado, Laura Blaya-Peña, Joan Siquier-Padilla, J J Coughlan, Vicente Peral, Xavier Rossello
AIM: The aim of clinical practice guidelines for ST elevation myocardial infarction (STEMI) and non-ST elevation acute coronary syndrome (NSTE-ACS) is to assist healthcare professionals in clinical decision-making. We evaluated the type of studies supporting these guidelines and their recommendations. METHODS: All references and recommendations in the 2013 and 2014 ACC/AHA and 2017 and 2020 (ESC clinical guidelines for STEMI and NSTE-ACS were reviewed. References were classified into meta-analyses, randomised, non-randomised, and other types (e...
July 12, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#34
Eric M Isselbacher, Ourania Preventza, James Hamilton Black, John G Augoustides, Adam W Beck, Michael A Bolen, Alan C Braverman, Bruce E Bray, Maya M Brown-Zimmerman, Edward P Chen, Tyrone J Collins, Abe DeAnda, Christina L Fanola, Leonard N Girardi, Caitlin W Hicks, Dawn S Hui, William Schuyler Jones, Vidyasagar Kalahasti, Karen M Kim, Dianna M Milewicz, Gustavo S Oderich, Laura Ogbechie, Susan B Promes, Elsie Gyang Ross, Marc L Schermerhorn, Sabrina Singleton Times, Elaine E Tseng, Grace J Wang, Y Joseph Woo, David P Faxon, Gilbert R Upchurch, Aaron W Aday, Ali Azizzadeh, Michael Boisen, Beau Hawkins, Christopher M Kramer, Jessica G Y Luc, Thomas E MacGillivray, S Christopher Malaisrie, Kathryn Osteen, Himanshu J Patel, Parag J Patel, Wanda M Popescu, Evelio Rodriguez, Rebecca Sorber, Philip S Tsao, Annabelle Santos Volgman, Joshua A Beckman, Catherine M Otto, Patrick T O'Gara, Anastasia Armbruster, Kim K Birtcher, Lisa de Las Fuentes, Anita Deswal, Dave L Dixon, Bulent Gorenek, Norrisa Haynes, Adrian F Hernandez, José A Joglar, W Schuyler Jones, Daniel Mark, Debabrata Mukherjee, Latha Palaniappan, Mariann R Piano, Tanveer Rab, Erica S Spatz, Jacqueline E Tamis-Holland, Y Joseph Woo
AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term surveillance of patients with aortic disease across its multiple clinical presentation subsets (ie, asymptomatic, stable symptomatic, and acute aortic syndromes). METHODS: A comprehensive literature search was conducted from January 2021 to April 2021, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, CINHL Complete, and other selected databases relevant to this guideline...
November 2023: Journal of Thoracic and Cardiovascular Surgery
#35
JOURNAL ARTICLE
Gonzalo Martínez, Alberto Fuensalida, Pablo Sepúlveda, Juan Francisco Bulnes, Jorge Quitral, Francisco Pacheco, Edith Valenzuela, Rosa Lazen, Alejandra Flores, Ricardo Zalaquett, Alejandro Martínez
BACKGROUND: Transcatheter aortic-valve implantation (TAVI) was introduced in 2002 and the first implants in our country were performed in 2010. AIM: To review the TAVI experience in our hospital, considering the technology improvements and gained experience throughout this period. MATERIAL AND METHODS: All patients undergoing TAVI in our center were included. Results and complications were adjudicated according to the Valve Academic Research Consortium-2 (VARC-2) criteria...
November 2022: Revista Médica de Chile
#36
JOURNAL ARTICLE
Karis Little, Aditi Singh, Angel Del Marco, María Llorián-Salvador, Maria Vargas-Soria, Mireia Turch-Anguera, Montse Solé, Noëlle Bakker, Sarah Scullion, Joan X Comella, Ingeborg Klaassen, Rafael Simó, Monica Garcia-Alloza, Vijay K Tiwari, Alan W Stitt
AIMS/HYPOTHESIS: Type 2 diabetes is associated with increased risk of cognitive decline although the pathogenic basis for this remains obscure. Deciphering diabetes-linked molecular mechanisms in cells of the cerebral cortex could uncover novel therapeutic targets. METHODS: Single-cell transcriptomic sequencing (scRNA-seq) was conducted on the cerebral cortex in a mouse model of type 2 diabetes (db/db mice) and in non-diabetic control mice in order to identify gene expression changes in distinct cell subpopulations and alterations in cell type composition...
June 23, 2023: Diabetologia
#37
JOURNAL ARTICLE
Juey-Jen Hwang, Hsien-Li Kao, Mao-Shin Lin, Cho-Kai Wu, Fu-Tien Chiang, Yi-Chih Wang
BACKGROUND: We have demonstrated that bioresorbable vascular scaffold (BVS) for ACC/AHA type C lesions was associated with higher risks of long-term target lesion revascularization (TLR) and target lesion failure (TLF). We determined the specific time after which higher risks of BVS for type C lesions are reduced in a longer-term follow-up. METHODS: We analyzed data of 457 patients (59 ± 12 years, 87% male) with 714 BVS implanted for 529 lesions and a median follow-up of 56...
June 20, 2023: Journal of the Formosan Medical Association
#38
JOURNAL ARTICLE
Pamela M Rist, Julie E Buring, Nancy R Cook, Tobias Kurth
BACKGROUND: Migraine with aura (MA) is associated with cardiovascular disease (CVD) independently from traditional vascular risk factors. However, the importance of MA on CVD occurrence relative to existing cardiovascular prediction tools remains unclear. OBJECTIVES: In this study, we sought to determine if adding MA status to 2 CVD risk prediction models improves risk prediction. METHODS: Participants enrolled in the Women's Health Study self-reported MA status and were followed for incident CVD events...
June 13, 2023: Journal of the American College of Cardiology
#39
Theodore A Bass, J Dawn Abbott, Ehtisham Mahmud, Sahil A Parikh, Jamil Aboulhosn, Mahi L Ashwath, Bryan Baranowski, Lisa Bergersen, Hannah I Chaudry, Megan Coylewright, Ali E Denktas, Kamal Gupta, J Antonio Gutierrez, Jonathan Haft, Beau M Hawkins, Howard C Herrmann, Navin K Kapur, Sena Kilic, John Lesser, C Huie Lin, Rodrigo Mendirichaga, Vuyisile T Nkomo, Linda G Park, Dawn R Phoubandith, Nishath Quader, Michael W Rich, Kenneth Rosenfield, Saher S Sabri, Murray L Shames, Stanton K Shernan, Kimberly A Skelding, Jacqueline Tamis-Holland, Vinod H Thourani, Jennifer A Tremmel, Seth Uretsky, Jessica Wageman, Frederick Welt, Brian K Whisenant, Christopher J White, Celina M Yong, Lisa A Mendes, James A Arrighi, John P Breinholt, Jennifer Day, G William Dec, Ali E Denktas, David Drajpuch, Nadeen Faza, Sanjeev A Francis, Rebecca T Hahn, Susan D Housholder-Hughes, Sadiya S Khan, Meera Devi Kondapaneni, Kwan S Lee, C Huie Lin, Jamal Hussain Mahar, Shannon McConnaughey, Khusrow Niazi, Dorothy D Pearson, Lynn R Punnoose, Risheen S Reejhsinghani, Thomas Ryan, Frank E Silvestry, Michael A Solomon, Robert L Spicer, Gaby Weissman, Steven W Werns
No abstract text is available yet for this article.
June 2, 2023: Journal of Thoracic and Cardiovascular Surgery
#40
JOURNAL ARTICLE
Hanyi Hua, Lin Liu, Tao Zhu, Fengyue Cheng, He Qian, Fanglin Shen, Yu Liu
Hyperlipidemia is a common metabolic disorder, which can lead to obesity, hypertension, diabetes, atherosclerosis and other diseases. Studies have shown that polysaccharides absorbed by the intestinal tract can regulate blood lipids and facilitate the growth of intestinal flora. This article aims to investigate whether Tibetan turnip polysaccharide (TTP) plays a protective role in blood lipid and intestinal health via hepatic and intestinal axes. Here we show that TTP helps to reduce the size of adipocytes and the accumulation of liver fat, playing a dose-dependent effect on ADPN levels, suggesting an effect on lipid metabolism regulation...
July 30, 2023: Food Chem (Oxf)
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