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https://www.readbyqxmd.com/read/28719859/-curcumin-loaded-poly-d-l-lactide-co-glycolide-nanovesicles-induce-antinociceptive-effects-and-reduce-pronociceptive-cytokine-and-bdnf-release-in-spinal-cord-after-acute-administration-in-mice
#1
Stefano Pieretti, Amalendu P Ranjan, Amalia Di Giannuario, Anindita Mukerjee, Francesca Marzoli, Rita Di Giovannandrea, Jamboor K Vishwanatha
Given the poor bioavailability of curcumin, its antinociceptive effects are produced after chronic intravenous administration of high doses, while poly (d,l-lactide-co-glycolide)-loaded vesicles (PLGA) can improve drug delivery. This paper investigates the antinociceptive effects of curcumin-loaded PLGA nanovesicles (PLGA-CUR) administered via intravenous (i.v.) or intrathecal (i.t.) routes at low and high doses. The following models of pain were used: formalin test, zymosan-induced hyperalgesia and sciatic nerve ligation inducing neuropathic allodynia and hyperalgesia...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28715397/magnetic-and-thermal-sensitive-poly-n-isopropylacrylamide-based-microgels-for-magnetically-triggered-controlled-release
#2
Chih-Yu Kuo, Ting-Yu Liu, Kuan-Syun Wang, Andri Hardiansyah, Yen-Ting Lin, Hsueh-Yung Chen, Wen-Yen Chiu
Magnetically and thermally sensitive poly(N-isopropylacrylamide) (PNIPAAm)/Fe3O4-NH2 microgels with the encapsulated anti-cancer drug curcumin (Cur) were designed and fabricated for magnetically triggered release. PNIPAAm-based magnetic microgels with a spherical structure were produced via a temperature-induced emulsion followed with physical-crosslinking by mixing PNIPAAm, polyethylenimine (PEI), and Fe3O4-NH2 magnetic nanoparticles. Because of their dispersity, the Fe3O4-NH2 nanoparticles were embedded inside the polymer matrix...
July 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28711016/therapeutic-supermolecular-micelles-of-vitamin-e-succinate-grafted-%C3%AE%C2%B5-polylysine-as-potential-carriers-for-curcumin-enhancing-tumour-penetration-and-improving-therapeutic-effect-on-glioma
#3
He-Lin Xu, Zi-Liang Fan, De-Li ZhuGe, Bi-Xin Shen, Bing-Hui Jin, Jian Xiao, Cui-Tao Lu, Ying-Zheng Zhao
Severe toxicity and poor tumour penetration are two intrinsic limited factors to hinder the broad clinical application for most of first-line chemotherapeutics. In this study, a novel vitamin E succinate-grafted ε-polylysine (VES-g-PLL) polymer was synthesized by using ε-polylysine as backbone. By adjusting VES graft ratio, VES-g-PLL (50) with a theoretic VES graft ratio of 50% could self-assemble into a supermolecular micelle with a hydrodynamic diameter (Dh) of ca.20nm, and Zeta potential of 19.6mV. VES-g-PLL micelles themselves displayed a strong anti-tumour effect on glioma...
July 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28707264/evaluation-of-propylene-glycol-nanoliposomes-containing-curcumin-on-burn-wound-model-in-rat-biocompatibility-wound-healing-and-anti-bacterial-effects
#4
Nooshin Kianvash, Abbas Bahador, Maryam Pourhajibagher, Homanaz Ghafari, Vahid Nikoui, Sayed Mehdi Rezayat, Ahmad Reza Dehpour, Alireza Partoazar
Curcumin is an effective wound healing agent in burn therapy, but due to its low bioavailability, it is required to be formulated for topical therapy. Liposomal nanocarriers are developed as stable and efficient dermal delivery systems. In this study, we prepared curcumin-propylene glycol liposomes (Cur-PgL) to treat animals subjected to second degree burns. The characterization tests confirmed the production of monodisperse nanoliposomes of average size of about 145 nm with high entrapment efficiency percentage and a sustained release behavior...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28702978/the-evolution-of-artificial-hair-implantation
#5
M Agrawal, J Lotti, K França, M Fioranelli, M G Roccia, T Lotti
From the beginning, artificial hair implantation has aroused a lot of interest, sometimes controversial, in the field of hair restoration. The artificial fiber must be of high quality and biocompatible. Biofibre® is a very fine fiber having diameter of 80 m. The standard length of this fiber is 15 or 30 cm, to satisfy multiple patient requests. They are available in 13 colors and 3 different shapes (straight, wavy and curly). Artificial hair implant is indicated in all (male and female) cases of androgenetic alopecia, especially for those who show dismal response to medical therapies and have poor donor area supply for hair transplantation...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28701016/tolerance-induction-of-horse-allergy-by-horse-contact-with-curly-horses
#6
W Mitlehner, H C Mitlehner
A horse allergic rider completed 60 riding lessons on Curly Horses within six months. This rider has become clinically tolerant to normal horse breeds within this time. This case may indicate that riding and brushing ABCR Curly Horses after 60 riding hours facilitates tolerance induction. Our data indicate that this could be a valid alternative to the common recommendation to strictly avoid horse riding.
July 2017: Pneumologie
https://www.readbyqxmd.com/read/28697469/differential-expression-of-curs-gene-during-various-growth-stages-climatic-condition-and-soil-nutrients-in-turmeric-curcuma-longa-towards-site-specific-cultivation-for-high-curcumin-yield
#7
I Sriram Sandeep, Suryasnata Das, Noohi Nasim, Antaryami Mishra, Laxmikanta Acharya, Raj Kumar Joshi, Sanghamitra Nayak, Sujata Mohanty
Curcuma longa L., accumulates substantial amount of curcumin and essential oil. Little is known about the differential expression of curcumin synthase (CURS) gene and consequent curcumin content variations at different agroclimatic zones. The present study aimed to evaluate the effect of climate, soil and harvesting phase on expression of CURS gene for curcumin yield in two high yielding turmeric cultivars. Expression of CURS gene at different experimental zones as well as at different harvesting phase was studied through transcriptional analysis by qRT-PCR...
July 4, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28694759/using-curcumin-to-prevent-structural-impairments-of-testicles-in-rats-induced-by-sodium-metabisulfite
#8
Reza Mahmoudi, Zahra Honarmand, Saied Karbalay-Doust, Mehrzad Jafari-Barmak, Mohsen Nikseresht, Ali Noorafshan
Sodium metabisulfite (Na-MBS) is a disinfectant and preservative agent. Some organ including testicle would be in danger in the case of Na-MBS consumption. Curcumin (CUR) is the constituent of turmeric with protective properties. The effect of CUR on testicles in rats exposed to Na-MBS evaluated using stereological methods. Sprague-Dawley rats were divided into eight groups. The rats in groups I to VIII received the following respectively: distilled water, CUR (100 mg/kg/day), low (0.7 mg/kg/day: acceptable daily intake), intermediate (7 mg/ kg/day), and high (70 mg/kg/day) doses of Na-MBS, and low, intermediate, and high doses of Na-MBS plus CUR...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28681332/association-of-silver-nanoparticles-and-curcumin-solid-dispersion-antimicrobial-and-antioxidant-properties
#9
Thais Francine Alves, Marco V Chaud, Denise Grotto, Angela Faustino Jozala, Raksha Pandit, Mahendra Rai, Carolina Alves Dos Santos
The last century, more precisely after 1945, was marked by major advances in the treatment of infectious diseases which promoted a decrease in mortality and morbidity. Despite these advances, currently the development of antimicrobial resistance has been growing drastically and therefore there is a pressing need to search for new compounds. Silver nanoparticles (AgNps) have been demonstrating good antimicrobial activity against different bacteria, viruses, and fungi. Curcumin (CUR) extracted from rhizomes of Curcuma longa has a variety of applications including antiinflammatory, antioxidant, and antibacterial agent...
July 5, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28678551/nano-encapsulated-metformin-curcumin-in-plga-peg-inhibits-synergistically-growth-and-htert-gene-expression-in-human-breast-cancer-cells
#10
Raana Farajzadeh, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Shahrzad Javidfar, Javid Lotfi-Attari, Hadi Sadeghzadeh, Vahid Shafiei-Irannejad, Nosratollah Zarghami
The study was aimed at investigating the synergistic inhibitory effect of unique combinational regimen of nanocapsulated Metformin (Met) and Curcumin (Cur) against T47D breast cancer cells. For this purpose, Met and Cur were co-encapsulated in PEGylated PLGA nanoparticles (NPs) and evaluated for their therapeutic efficacy. The morphology and dynamic light scattering (DLS) analyses were carried out to optimize the nanoformulations. Drug release study was performed using dialysis method and then the cytotoxic and inhibitory effect of individual and combined drugs on expression level of hTERT in T47D breast cell line were evaluated using MTT assay and qPCR, respectively...
July 5, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28675599/a-novel-hollow-nagdf4-afn-nanosystem-based-on-relay-race-release-for-therapy
#11
Jie Zhou, Hanchun Yao, Lingchang Meng, Chong Sun, Weiran Ye, Qiuzheng Du
To develop a multifunctional nanomaterial for dual-mode imaging and synergetic chemotherapy, curcumin (CUR) was physically entrapped into hollow upconversion NaGdF4, then attached AFn loaded with doxorubicin (DOX) to the surface of NaGdF4. Followed modifying targeting reagent folic acid (FA), obtaining the CUR/NaGdF4-DOX/AFn-FA conjugate for cancer treatment. X-ray diffraction, SEM and TEM and FT-IR proved the successful preparation of hexagonal-phase NaGdF4 and NaGdF4-AFn-FA. And NaGdF4-AFn-FA had no evident toxicity...
July 4, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28674790/curcumin-photodynamic-effect-in-the-treatment-of-the-induced-periodontitis-in-rats
#12
Letícia Helena Theodoro, Marcio Luiz Ferro-Alves, Mariéllen Longo, Marta Aparecida Alberton Nuernberg, Renata Pironato Ferreira, Adriele Andreati, Edilson Ervolino, Cristiane Duque, Valdir Gouveia Garcia
This study assessed the effect of curcumin as a photosensitizer in antimicrobial photodynamic therapy (aPDT) for the treatment of induced periodontitis in rats. Periodontitis was induced via a ligature around the mandibular first molar on the left side of 96 rats. The ligature was removed 7 days later, and the animals were randomized into four groups: NT, no local treatment; CUR, irrigation with curcumin solution (40 μM); LED, irradiation with a light-emitting diode (LED, InGaN, 465-485 nm, 200 mW/cm(2), 60 s); and aPDT, irrigation with curcumin solution (40 μM) followed by irradiation with LED...
July 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28673607/nanoparticle-formulations-to-enhance-tumor-targeting-of-poorly-soluble-polyphenols-with-potential-anticancer-properties
#13
REVIEW
Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari
Polyphenols have been extensively studied for their relevant anticancer activity. Quite often however their instability, extensive metabolization, low bioavailability and poor solubility limit their application in cancer prevention and therapy. Formulation in nanoparticles has been widely proposed as a means to overcome these limits, maximize localization and specific activity at tumor site. The present review is intended as an update of literature regarding nanoparticulate carriers aimed to deliver polyphenols to the cancer site...
June 30, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28663065/potential-therapeutic-and-protective-effect-of-curcumin-against-stroke-in-the-male-albino-stroke-induced-model-rats
#14
Yuanyuan Zhang, Yi Yan, Yi Cao, Yongtao Yang, Qing Zhao, Rui Jing, Jiayi Hu, Juan Bao
AIMS: The present study was carried out to understand the therapeutic effect of curcumin (CUR) against stroke in the experimental animal model. The study investigates the healing effect of CUR on mitochondrial dysfunction and inflammation. MATERIALS AND METHODS: Male albino, Wistar strain rats were used for the induction of middle cerebral artery occlusion (MCAO), and reperfusion. Enzyme-linked immunosorbent assay (ELISA) was used for the determination of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in the brain region...
June 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/28661679/viewing-molecular-and-interface-interactions-of-curcumin-amorphous-solid-dispersions-for-comprehending-dissolution-mechanisms
#15
Jing Li, Xin Wang, Chang Li, Na Fan, Jian Wang, Zhonggui He, Jin Sun
Tautomeric curcumin amorphous solid dispersions (Cur ASDs) formulated with various typical polymers (polyethylene glycol 6000 (PEG), polyvinylpyrrolidone K30 (PVP), Eudragit EPO (EuD), EuD/hydroxypropylmethyl cellulose E50 (HPMC), and PVP/EuD) were probed using in situ Raman imaging plus spectroscopy and molecular modeling techniques, and dissolution mechanism of Cur ASDs were revealed mainly through molecular and interfacial interactions formed between Cur and polymer. The results demonstrated that Cur of keto form existed in Cur-PEG, Cur of enol form was shown in Cur-PVP, while Cur-EuD or Cur ASDs formulated with EuD as component had Cur of keto form and enol form...
July 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28652738/glycyrrhetinic-acid-functionalized-mesoporous-silica-nanoparticles-as-hepatocellular-carcinoma-targeted-drug-carrier
#16
Yongjiu Lv, Jingjing Li, Huali Chen, Yan Bai, Liangke Zhang
In this study, a glycyrrhetinic acid-functionalized mesoporous silica nanoparticle (MSN-GA) was prepared for active tumor targeting. MSN-GA exhibited satisfactory loading capacity for insoluble drugs, uniform size distribution, and specific tumor cell targeting. Glycyrrhetinic acid, a hepatocellular carcinoma-targeting group, was covalently decorated on the surface of MSN via an amido bond. The successful synthesis of MSN-GA was validated by the results of Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), and zeta potential measurement...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28648521/ratiometric-co-delivery-of-multiple-chemodrugs-in-a-single-nanocarrier
#17
Chao Chen, Ran Tao, Dan Ding, Deling Kong, Aiping Fan, Zheng Wang, Yanjun Zhao
Co-delivery of multiple anti-cancer drugs in a single nanoplatform has shown great promise in enhancing therapeutic efficacy and reducing adverse effects. However, the ratiometric dose control is pivotal, but often challenging in combinational nanomedicine. Here, we report the employment of cyclodextrin-bearing amphiphilic polymer conjugate micelles for ratiometric, non-covalent loading of three hydrophobic model drugs, curcumin (CUR), camptothecin (CPT), and doxorubicin (DOX) in one single nanocarrier. Each drug was physically encapsulated in the cyclodextrin-bearing polymer conjugate via guest-host complexation...
June 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28646779/polychlorinated-biphenyls-in-the-surrounding-of-an-e-waste-recycling-facility-in-north-rhine-westphalia-levels-in-plants-and-dusts-spatial-distribution-homologue-pattern-and-source-identification-using-the-combination-of-plants-and-wind-direction-data
#18
Marcel Klees, Katja Hombrecher, Dieter Gladtke
During this study the occurrence of polychlorinated biphenyls (PCBs) in the surrounding of an e-waste recycling facility in North-Rhine Westphalia was analysed. PCB levels were analysed in curly kale, spruce needles, street dusts and dusts. Conspicuously high PCB concentrations in curly kale and spruce needles were found directly northwards of the industrial premises. Furthermore a concentration gradient originating from the industrial premises to the residential areas in direction southwest to northeast was evident...
June 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28635562/nanoformulated-natural-therapeutics-for-management-of-streptozotocin-induced-diabetes-potential-use-of-curcumin-nanoformulation
#19
Yousra M El-Far, Mahmoud M Zakaria, Mahmoud M Gabr, Amal M El Gayar, Laila A Eissa, Ibrahim M El-Sherbiny
AIM: The goal of this study was to improve curcumin (CUR) aqueous solubility and bioavailability via nanoformulation, and then study its activity and mechanism of action as an antidiabetic agent. METHODS: CUR-loaded pluronic nanomicelles (CURnp) were prepared and characterized. Biochemical assessments were performed as well as histological, confocal and RTPCR studies on pancreatic target tissues. RESULTS: CURnp with a diameter of 333 ± 6 nm and ζ potential of -26...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28628096/nucleation-and-growth-of-a-bacterial-functional-amyloid-at-single-fiber-resolution
#20
Mike Sleutel, Imke Van den Broeck, Nani Van Gerven, Cécile Feuillie, Wim Jonckheere, Claire Valotteau, Yves F Dufrêne, Han Remaut
Curli are functional amyloids produced by proteobacteria like Escherichia coli as part of the extracellular matrix that holds cells together into biofilms. The molecular events that occur during curli nucleation and fiber extension remain largely unknown. Combining observations from curli amyloidogenesis in bulk solutions with real-time in situ nanoscopic imaging at the single-fiber level, we show that curli display polar growth, and we detect two kinetic regimes of fiber elongation. Single fibers exhibit stop-and-go dynamics characterized by bursts of steady-state growth alternated with periods of stagnation...
June 19, 2017: Nature Chemical Biology
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