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Cécile Vors, Charles Couillard, Marie-Eve Paradis, Iris Gigleux, Johanne Marin, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
Background: High-fat meals induce postprandial inflammation. Resveratrol is a polyphenol known to prevent comorbidities associated with cardiovascular disease and exerts an anti-inflammatory action. There is also an increasing body of evidence supporting the role of curcumin, a polyphenol from the curcuminoid family, as a modulator of proinflammatory processes. Objective: The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity...
March 1, 2018: Journal of Nutrition
Mandy Hei Man Leung, Amy Q Shen
The ability to control particle size and size distribution of nanoparticles for drug delivery is essential because it impacts on the biodistribution and cellular uptake of nanoparticles. We present a novel microfluidic assisted nanoprecipitation strategy that enables synthesis of surfactant-free curcumin encapsulated poly(lactide-co-glycolide) nanoparticles (Cur-PLGA NP) with adjustable particle diameters (30-70nm) and narrow particle size distribution (polydispersity index less than 0.2). Our Cur-PLGA NP exhibit excellent colloidal stability and inhibit degradation of curcumin...
March 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Muyang Yang, Lixia Yu, Ruiwei Guo, Anjie Dong, Cunguo Lin, Jianhua Zhang
Synergistic combination therapy by integrating chemotherapeutics and chemosensitizers into nanoparticles has demonstrated great potential to reduce side effects, overcome multidrug resistance (MDR), and thus improve therapeutic efficacy. However, with regard to the nanocarriers for multidrug codelivery, it remains a strong challenge to maintain design simplicity, while incorporating the desirable multifunctionalities, such as coloaded high payloads, targeted delivery, hemodynamic stability, and also to ensure low drug leakage before reaching the tumor site, but simultaneously the corelease of drugs in the same cancer cell...
March 15, 2018: Nanomaterials
Shihong Shao, Yun Zhu, Tingting Meng, Yupeng Liu, Yun Hong, Ming Yuan, Hong Yuan, Fuqiang Hu
Liver metastasis is a leading death cause in colorectal cancer. The pathological differences between orthotopic tumors and metastatic lesions increased the therapeutic difficulty of metastasis. Herein, the α5β1 integrin receptor expression on metastatic cells was firstly measured, the result showed that metastatic cells expressed higher α5β1 integrin compared with original cells from orthotopic tumors. Afterwards, RPM peptide modified chitosan-stearic (RPM-CSOSA) was designed based on α5β1 integrin expression...
March 13, 2018: Molecular Pharmaceutics
C A Rajabu, G G Kennedy, J Ndunguru, E M Ateka, F Tairo, L Hanley-Bowdoin, J T Ascencio-Ibáñez
Geminiviruses are devastating single-stranded DNA viruses that infect a wide variety of crops in tropical and subtropical areas of the world. Tomato, which is a host for more than 100 geminiviruses, is one of the most affected crops. Developing plant models to study geminivirus-host interaction is important for the design of virus management strategies. In this study, "Florida Lanai" tomato was broadly characterized using three begomoviruses (Tomato yellow leaf curl virus, TYLCV ; Tomato mottle virus, ToMoV; Tomato golden mosaic virus, TGMV) and a curtovirus (Beet curly top virus, BCTV)...
March 9, 2018: Journal of Virological Methods
Yi-Lun Ying, Yong-Xu Hu, Rui Gao, Ru-Jia Yu, Zhen Gu, Luke P Lee, Yi-Tao Long
Capturing real-time electron transfer, enzyme activity, molecular dynamics, and biochemical messengers in living cells is essential for un-derstanding the signaling pathways and cellular communications. However, there is no generalizable method for characterizing a broad range of redox-active species in a single living cell at the resolution of cellular compartments. Although nanoelectrodes have been applied in the intracellular detection of redox-active species, the fabrication of nanoelectrodes to maximize the signal-to-noise ratio of the probe remains challenging because of the stringent requirements of 3D fabrication...
March 12, 2018: Journal of the American Chemical Society
Sri I Pulungan, Ryoichi Yano, Yoshihiro Okabe, Takuji Ichino, Mikiko Kojima, Yumiko Takebayashi, Hitoshi Sakakibara, Tohru Ariizumi, Hiroshi Ezura
Leaves are the major plant organs with a primary function for photosynthesis. Auxin controls various aspects of plant growth and development, including leaf initiation, expansion, and differentiation. Unique and intriguing auxin features include its polar transport, which is mainly controlled by the AUX1/LAX and PIN gene families as influx and efflux carriers, respectively. The role of AUX1/ LAX genes in root development is well documented, but the role of these genes in leaf morphogenesis remains unclear. Moreover, most studies have been conducted in the plant model Arabidopsis thaliana, while studies in tomato are still scarce...
March 8, 2018: Plant & Cell Physiology
Sauraj, S Uday Kumar, Vinay Kumar, Ruchir Priyadarshi, P Gopinath, Yuvraj Singh Negi
In the present study, novel pH-responsive prodrug nanoparticles based on xylan-curcumin (xyl-cur) conjugate were developed to enhance the therapeutic efficacy of curcumin in cancer therapy. The synthesis of xyl-cur conjugate (prodrug) was confirmed by FT-IR,1 H NMR, UV-vis and fluorescence spectroscopy. The xyl-cur prodrug was subsequently self-assembled in to nanoparticles (xyl-cur prodrug NPs) in an aqueous medium with the average particle size 253 nm and the zeta potential of -18.76 mV. The xyl-cur prodrug NPs were highly pH-sensitive in nature and most of the drug was released at lower pH...
May 15, 2018: Carbohydrate Polymers
Song Yi Lee, Hyun-Jong Cho
Nanoassembly (NA) based on a D-α-tocopherol succinate (αTS) conjugated lysozyme (Lys) (Lys-αTS) was fabricated for tumor-selective delivery of curcumin (CUR) for breast cancer therapy. Lys and αTS were used as a biocompatible enzyme and a hydrophobic residue, respectively, for the preparation of nanocarriers in this study. Compared with CUR-loaded cross-linked Lys (c-Lys/CUR) NA, Lys-αTS/CUR NA exhibited a smaller hydrodynamic size (213 nm mean diameter), a narrower size distribution, and a more spherical shape...
November 2018: Drug Delivery
Xinyu Wang, Jiahua Pu, Bolin An, Yingfeng Li, Yuequn Shang, Zhijun Ning, Yi Liu, Fang Ba, Jiaming Zhang, Chao Zhong
Programming living cells to organize inorganic nano-objects (NOs) in a spatiotemporally precise fashion would advance new techniques for creating ordered ensembles of NOs and new bio-abiotic hybrid materials with emerging functionalities. Bacterial cells often grow in cellular communities called biofilms. Here, a strategy is reported for programming dynamic biofilm formation for the synchronized assembly of discrete NOs or hetero-nanostructures on diverse interfaces in a dynamic, scalable, and hierarchical fashion...
March 8, 2018: Advanced Materials
Eleuza R Machado, Iriani R Maldonade, Roberta F R Riquette, Vinícios S Mendes, Rodrigo Gurgel-Gonçalves, Veronica C Ginani
The consumption of raw vegetables is related to health benefits. However, these foods might be source of foodborne diseases. The objective of the present study was to perform a microbiological and parasitological evaluation of the leafy vegetables commercially sold in five regions of Brazil at public wholesale markets. The 12 types of leafy vegetables (144 samples) were curly lettuce, looseleaf lettuce, red lettuce, chives, coriander, kale, basil, arugula, parsley, iceberg lettuce, chicory, and bean sprouts...
April 2018: Journal of Food Protection
Preeti Verma, Vijay Veer Saharan, Surendra Nimesh, Arvind Pratap Singh
AIMS: The present study was designed to assess the phenotypic traits and virulence determinants of vegetables/fruits-origin E. coli and Salmonella strains. METHODS AND RESULTS: A total of 520 fresh vegetables/fruits samples were analyzed for the presence of E. coli, including Shiga-toxin producing E. coli (STEC), and Salmonella. The vegetables/fruits-origin E. coli and Salmonella strains were further assessed for antimicrobial resistance, biofilm formation, extracellular matrix production, and in-vitro invasion/intracellular survivability assays...
March 7, 2018: Journal of Applied Microbiology
Samira Malekmohammadi, Hassan Hadadzadeh, Hossein Farrokhpour, Zahra Amirghofran
In the present study, a new sandwich-like nanocomposite as a multifunctional smart nanocarrier for curcumin (Cur) targeted delivery and cell imaging was prepared by immobilization of gold nanoparticles on folic acid-modified dendritic mesoporous silica-coated reduced graphene oxide nanosheets (AuNPs@GFMS). The physical and chemical properties of the nanocomposite were investigated by atomic force microscopy (AFM), transmission electron microscopy (TEM), X-ray diffraction (XRD), UV-Vis, field-emission scanning electron microscopy (FE-SEM), Fourier transformation infrared (FT-IR), and Brunauer-Emmett-Teller (BET) surface area analysis...
March 7, 2018: Soft Matter
Andreas Hjelm Brandt
This PhD project is based on a longstanding collaboration between physicists and engineers from the Center of Fast Ultrasound Imaging (CFU) at the Technical University of Denmark and medical doctors from the department of Radiology at Rigshospitalet. The intent of this cooperation is to validate new ultrasonic methods for future clinical use. 
Study I compares two B-mode ultrasound methods: the new experimental technique Synthetic Aperture Sequential Beam-forming combined with Tissue Harmonic Imaging (SASB-THI), and a conventional technique combined with THI...
March 2018: Danish Medical Journal
Fang Hui, Jinyu Zhu, Pengcheng Hu, Lei Meng, Binglin Zhu, Yan Guo, Baoguo Li, Yuntao Ma
Background and Aims: Global agriculture is facing the challenge of a phenotyping bottleneck due to large-scale screening/breeding experiments with improved breeds. Phenotypic analysis with high-throughput, high-accuracy and low-cost technologies has therefore become urgent. Recent advances in image-based 3D reconstruction offer the opportunity of high-throughput phenotyping. The main aim of this study was to quantify and evaluate the canopy structure of plant populations in two and three dimensions based on the multi-view stereo (MVS) approach, and to monitor plant growth and development from seedling stage to fruiting stage...
March 2, 2018: Annals of Botany
R Wang, J-Y Zhang, M Zhang, M-G Zhai, S-Y Di, Q-H Han, Y-P Jia, M Sun, H-L Liang
OBJECTIVE: Ischemia-reperfusion (IR) injury remains an unresolved and complicated situation in clinical practice. In this study, H9c2 cardiomyocytes were subjected to curcumin (Cur) treatment in the absence or presence of the silent information regulator 3 (SIRT3) inhibitor 3-TYP and were then subjected to IR. MATERIALS AND METHODS: H9c2 cells and male Sprague-Dawley (SD) rats were cultured. MTT assay was performed to assess H9c2 cell viability. Cellular apoptosis was analyzed by TUNEL assay...
February 2018: European Review for Medical and Pharmacological Sciences
Jiao Wang, Qiang Liu, Linnan Yang, Xiaofei Xia, Rongrong Zhu, Shengguang Chen, Mei Wang, Liming Cheng, Xianzheng Wu, Shilong Wang
Cervical cancer is the fourth most common cancer in women worldwide, and existing treatments cause severe side effects and great burdens. Thus, the development of safe, inexpensive therapeutic agents is necessary. Curcumin (Cur), a well-known natural product, exerts promising anti-cancer activities against various cancer types. However, its therapeutic efficacy is severely restrained due to rapid degradation, poor aqueous solubility, and low bioavailability. The objective of this study was to investigate the therapeutic potential of novel curcumin-loaded TPGS/F127/P123 mixed polymeric micelles (Cur@NPT100) for cervical cancer treatment...
December 1, 2017: Journal of Biomedical Nanotechnology
Anna M Duraj-Thatte, Pichet Praveschotinunt, Trevor R Nash, Frederick R Ward, Neel S Joshi
Extracellular appendages play a significant role in mediating communication between bacteria and their host. Curli fibers are a class of bacterial fimbria that is highly amenable to engineering. We demonstrate the use of engineered curli fibers to rationally program interactions between bacteria and components of the mucosal epithelium. Commensal E. coli strains were engineered to produce recombinant curli fibers fused to the trefoil family of human cytokines. Biofilms formed from these strains bound more mucins than those producing wild-type curli fibers, and modulated mucin rheology as well...
February 22, 2018: Scientific Reports
R Thomas Sherba, Kathryn A Coxe, Beth E Gersper, Jessica V Linley
This qualitative study of over 800 participants focused on the employment experiences of consumers of substance abuse treatment programs to provide a better understanding of what employment services are offered and what needs treatment agencies have in the area of employment services, examining barriers and facilitators from both the consumer and provider perspectives. Data were collected via a mixed research methodology of focus groups and surveys from July 2015 through June 2016 in a large Midwestern U.S...
April 2018: Journal of Substance Abuse Treatment
Panchanan Maiti, Leela Paladugu, Gary L Dunbar
BACKGROUND: Neuroinflammation and the presence of amyloid beta protein (Aβ) and neurofibrillary tangles are key pathologies in Alzheimer's disease (AD). As a potent anti-amyloid and anti-inflammatory natural polyphenol, curcumin (Cur) could be potential therapies for AD. Unfortunately, poor solubility, instability in physiological fluids, and low bioavailability limit its clinical utility. Recently, different lipid modifications in the formulae of Cur have been developed that would enhance its therapeutic potential...
February 23, 2018: BMC Neuroscience
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