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https://www.readbyqxmd.com/read/28930649/ph-multistage-responsive-micellar-system-with-charge-switch-and-peg-layer-detachment-for-co-delivery-of-paclitaxel-and-curcumin-to-synergistically-eliminate-breast-cancer-stem-cells
#1
Zhe Yang, Na Sun, Rui Cheng, Chenyang Zhao, Zerong Liu, Xian Li, Jie Liu, Zhongmin Tian
Several studies have demonstrated that cancer stem cells (CSCs) are responsible for replenishing bulk tumor cells, generating new tumors and causing metastasis and relapse. Although combination therapy with multiple chemotherapeutics is considered to be a promising approach for simultaneously eliminating non-CSCs and CSCs, it is difficult to deliver drugs into the inner region of a solid tumor where the CSCs are located due to a lack of capillaries. Here, we synthesized a pH-sensitive polymer, poly(ethylene glycol)-benzoic imine-poly(γ-benzyl-l-aspartate)-b-poly(1-vinylimidazole) block copolymer (PPBV), to develop a pH multistage responsive micellar system for co-delivering paclitaxel and curcumin and synergistically eliminating breast cancer stem cells (bCSCs) and non-bCSCs...
September 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/28925166/-comparison-of-pharmacokinetics-of-curcumin-in-rats-administered-with-two-kinds-of-polymeric-micelles
#2
Di Zhang, Qian Xu, Ke Liu, Hui Xu
To investigate the effect of end-capped modification of mPEG-PLA with Boc-phenylalanine(BP) on pharmacokinetic characteristics of curcumin(CUR) loaded micelles, and then provide experimental evidence for prescription optimization. Healthy male SD rats were randomly divided into three groups and they were intravenously administered with a single injection of CUR-mPEG-PLA micelles, CUR-mPEG-PLA-BP micelles and reference formulations DMSO solution(n=6). The doses were 20 mg•kg⁻¹ in term of CUR. Blood samples were collected before and after administration, and the concentration of curcumin in blood plasma was determined by HPLC to draw time-concentration curve...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28913868/alterations-of-c-di-gmp-turnover-proteins-modulate-semi-constitutive-rdar-biofilm-formation-in-commensal-and-uropathogenic-escherichia-coli
#3
Annika Cimdins, Roger Simm, Fengyang Li, Petra Lüthje, Kaisa Thorell, Åsa Sjöling, Annelie Brauner, Ute Römling
Agar plate-based biofilm of enterobacteria like Escherichia coli is characterized by expression of the extracellular matrix components amyloid curli and cellulose exopolysaccharide, which can be visually enhanced upon addition of the dye Congo Red, resulting in a red, dry, and rough (rdar) colony morphology. Expression of the rdar morphotype depends on the transcriptional regulator CsgD and occurs predominantly at ambient temperature in model strains. In contrast, commensal and pathogenic isolates frequently express the csgD-dependent rdar morphotype semi-constitutively, also at human host body temperature...
September 15, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28901681/a-vigs-screen-identifies-immunity-in-the-arabidopsis-pla-1-accession-to-viruses-in-two-different-genera-of-the-geminiviridae
#4
Maria Ines Reyes, Miguel A Flores-Vergara, Orlene Guerra-Peraza, Cyprian Rajabu, Jigar Desai, Yokiko H Hiromoto-Ruiz, Joseph Ndunguru, Linda Hanley-Bowdoin, Susanne Kjemtrup, Jose T Ascencio-Ibáñez, Dominique Robertson
Geminiviruses are DNA viruses that cause severe crop losses in different parts of the world, and there is a need for genetic sources of resistance to help combat them. Arabidopsis has been used as a source for virus resistance genes that derive from alterations in essential host factors. We used a virus-induced gene silencing (VIGS) vector derived from the geminivirus Cabbage leaf curl virus (CaLCuV) to assess natural variation in virus-host interactions in 190 Arabidopsis accessions. Silencing of CH-42, encoding a protein needed to make chlorophyll, was used as a visible marker to discriminate asymptomatic accessions from those showing resistance...
September 13, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28891961/visible-light-cured-glycol-chitosan-hydrogel-containing-a-beta-cyclodextrin-curcumin-inclusion-complex-improves-wound-healing-in-vivo
#5
Sun-Jung Yoon, Hoon Hyun, Deok-Won Lee, Dae Hyeok Yang
Scarless wound healing is ideal for patients suffering from soft tissue defects. In this study, we prepared a novel wet dressing (β-CD-ic-CUR/GC) based on the visible light-cured glycol chitosan (GC) hydrogel and inclusion complex between beta-cyclodextrin (β-CD) and curcumin (CUR). We also evaluated its efficacy in the acceleration of wound healing as compared to that of CUR-loaded GC (CUR/GC). The conjugation of glycidyl methacrylate (GM) to GC for photo-curing was confirmed by ¹H-NMR measurement, and the photo-cured GC hydrogel was characterized by the analyses of rheology, swelling ratio, SEM and degradation rate...
September 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28889298/semiquantitative-analysis-of-the-red-dry-and-rough-colony-morphology-of-salmonella-enterica-serovar-typhimurium-and-escherichia-coli-using-congo-red
#6
Annika Cimdins, Roger Simm
The Congo Red (CR) assay is a standard biofilm test assessing the colony morphology of bacteria growing on agar plates supplemented with the diazo dye Congo Red. Biofilm forming Salmonella enterica serovar Typhimurium and Escherichia coli produce a red, dry, and rough (rdar) morphotype on CR-plates. The phenotype is characterized by staining of the extracellular matrix components curli (brown color) and cellulose (pink color) by CR. This method allows semiquantitative determination of the expression level of the individual matrix components and dissection of the regulatory networks controlling their production in response to c-di-GMP levels...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28889292/congo-red-stain-identifies-matrix-overproduction-and-is-an-indirect-measurement-for-c-di-gmp-in-many-species-of-bacteria
#7
Christopher J Jones, Daniel J Wozniak
Congo red is a diazo textile dye that has been used to visualize the production of amyloid fibers for nearly a century. Microbiological applications were later developed, especially in identifying strains that produce amyloid appendages called curli and overexpressing polysaccharides in the biofilm matrix. The second messenger cyclic diguanylate (c-di-GMP) regulates the production of biofilm matrix polysaccharides, and therefore Congo red staining of samples can be utilized as an indirect measurement of elevated c-di-GMP production in bacteria...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28889291/experimental-detection-and-visualization-of-the-extracellular-matrix-in-macrocolony-biofilms
#8
Diego O Serra, Regine Hengge
By adopting elaborate three-dimensional morphologies that vary according to their extracellular matrix composition, macrocolony biofilms offer a unique opportunity to interrogate about the roles of specific matrix components in shaping biofilm architecture. Here, we describe two methods optimized for Escherichia coli that profit from morphology and the high level of structural organization of macrocolonies to gain insight into the production and assembly of amyloid curli and cellulose-the two major biofilm matrix elements of E...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28887965/preparation-characterization-and-anti-colitis-activity-of-curcumin-asafoetida-complex-encapsulated-in-turmeric-nanofiber
#9
Sreeraj Gopi, Augustine Amalraj, Shintu Jude, Karthik Varma, T R Sreeraj, Józef T Haponiuk, Sabu Thomas
Ulcerative colitis (UC) is a main form of inflammatory bowel disease (IBD). Asafoetida (ASF) and turmeric have traditionally been used for the treatment of various inflammatory diseases, including UC, because ASF is rich in sulfur compounds and turmeric contains curcumin (CUR). Turmeric nanofiber (TNF), the modified cell wall component of turmeric is considered to play important role in the human diet, health and can be used as a carrier agent to encapsulate bioactive components. A novel gut health product (GHP) was formulated by encapsulation of ASF and CUR complex onto TNF...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28886517/tunable-ph-and-redox-responsive-drug-release-from-curcumin-conjugated-%C3%AE-polyglutamic-acid-nanoparticles-in-cancer-microenvironment
#10
Shameer Pillarisetti, S Maya, S Sathianarayanan, R Jayakumar
Tunable pH and redox responsive polymer was prepared using γ-polyglutamic acid (γ-PGA) with linker 3-mercaptopropionic acid (3-MPA) (γ-PGA_SH) via oxidation to obtain redox responsive disulfide (γ-PGA_SS) backbone and adipic acid dihydrazide (ADH) (γ-PGA_SS_ADH) with hydrazide functional group for pH responsiveness. Further curcumin (Cur) was conjugated through hydrazone bond of the γ-PGA_SS_ADH via Schiff base reaction to obtain (γ-PGA_SS_ADH_Cur). The prepared systems were characterized by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, Electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Qq-TOF-MS/MS) and Solid state nuclear magnetic resonance (SS NMR) techniques...
August 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28884598/skin-targeting-of-curcumin-solid-lipid-nanoparticles-engrossed-topical-gel-for-the-treatment-of-pigmentation-and-irritant-contact-dermatitis
#11
Shilpa Shrotriya, Nisharani Ranpise, Pournima Satpute, Bhagvat Vidhate
Irritant contact dermatitis (ICD) and hyperpigmentation are the problems associated with skin. Topical curcumin (CUR) although effective in hyperpigmentation and ICD, is a challenging molecule due to low-solubility. Encapsulation of CUR into solid lipid nanoparticles (SLNs) makes it amenable to topical dosing as their small size promotes its penetration into the skin. CUR-SLNs were prepared using Precirol ATO5 and Tween-80 by probe ultrasonication method. Further, CUR-SLNs were incorporated into Carbopol gel and investigated for ex-vivo skin permeation, skin deposition and skin irritation studies...
September 8, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28883197/an-abstraction-layer-to-facilitate-technical-interoperability-between-medical-records-and-knowledge-modules
#12
Martin Staudigel, Hans-Ulrich Prokosch, Stefan Kraus
Integrating clinical decision support (CDS) functions into an existing hospital information system (HIS) is often a tedious task. This problem area is so pervasive that the Arden Syntax, a widely used standard for CDS functions, assigned a specific designation, the so-called "curly braces problem". It derives from a pair of curly braces used to encapsulate any parameters required for the interactions with a HIS. The traditional approach is to leave the problem area of technical interoperability entirely to the specific institution, possibly entailing a considerable amount of initial programming work...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28881600/curcumin-induces-g2-m-cell-cycle-arrest-and-apoptosis-of-head-and-neck-squamous-cell-carcinoma-in-vitro-and-in-vivo-through-atm-chk2-p53-dependent-pathway
#13
An Hu, Jing-Juan Huang, Jing-Fei Zhang, Wei-Jun Dai, Rui-Lin Li, Zhao-Yang Lu, Jun-Li Duan, Ji-Ping Li, Xiao-Ping Chen, Jing-Ping Fan, Wei-Hua Xu, Hong-Liang Zheng
Studies have demonstrated that curcumin (CUR) exerts its tumor suppressor function in a variety of human cancers including head and neck squamous cell carcinoma (HNSCC). However, the exact underlying molecular mechanisms remain obscure. Here, we aim to test whether CUR affects ATM/Chk2/p53 signaling pathway, leading to the induction of cell cycle arrest, inhibition of angiogenesis of HNSCC in vitro and in vivo. To this end, we conducted multiple methods such as MTT assay, Invasion assay, Flow cytometry, Western blotting, RT-PCR, and transfection to explore the functions and molecular insights of CUR in HNSCC...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28875010/anti-apoptotic-effects-of-osteopontin-via-the-up-regulation-of-akt-mtor-%C3%AE-catenin-loop-in-acute-myeloid-leukemia-cells
#14
Mahdi Zahed Panah, Mohsen Nikbakht, Seyed Mehdi Sajjadi, Shahrbano Rostami, Amir Hossein Norooznezhad, Hosein Kamranzadeh Fumani, Ardeshir Ghavamzadeh, Saeed Mohammadi
Background: The conventional chemotherapeutic regimens which applied for treatment of acute myeloid leukemia (AML) mostly target tumor bulk but not leukemic stem cells (LSCs). Aberrant expression or activation of mediators such as osteopontin (OPN) or PI3K/PTEN/Akt/mTOR pathway plays a key role in making prone to develop leukemia. Preventing or treating cancer by curcumin (CUR) has been suggested recently. CUR induces apoptosis and growth inhibition through various mechanisms in leukemic cells. In present study, we tried to measure the toxic response in vitro to CUR for evaluation ofchangesin cell viability, survival and molecular-mediated resistance in primary AML cells...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28868838/aluminium-induced-oxidative-stress-apoptosis-and-alterations-in-testicular-tissue-and-sperm-quality-in-wistar-rats-ameliorative-effects-of-curcumin
#15
Ebrahim Cheraghi, Alireza Golkar, Kambiz Roshanaei, Behrang Alani
Background: Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. No studies have evaluated the possible effects of curcumin (CUR) on Al-induced reproductive dysfunction. Therefore, this study investigated the effects of CUR treatment on Al-induced reproductive damage. MATERIALS AND METHODS: In this experimental study, 40 male Wistar rats were allocated to the five groups (n=8) based on the treatment they received: no treatment (control), solvent [dimethyl sulfoxide (DMSO) or distilled water], CUR 10 mg/kg body weight (BW), Al chloride 10 mg/kg BW, and CUR+Al chloride (10 mg/kg BW/each alone)...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28866200/effect-of-ph-on-polyethylene-glycol-peg-induced-silk-microsphere-formation-for-drug-delivery
#16
Jianbing Wu, Xusheng Xie, Zhaozhu Zheng, Gang Li, Xiaoqin Wang, Yansong Wang
The effects of changing solution pH in the range of 3.6-10.0 during a one-step silk microsphere preparation process, by mixing silk and polyethylene glycol (PEG), was assessed. The microspheres prepared at low pH (3.6) showed a more homogeneous size (1-3μm) and less porous texture than those prepared at neutral pH. High pH (10.0) inhibited microsphere formation, yielding small and inhomogeneous microspheres. Compared to neutral pH, low pH also increased the content of silk crystalline β-sheet structure from approx...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28866151/liposomes-coated-with-thiolated-chitosan-as-drug-carriers-of-curcumin
#17
Riwang Li, Li Deng, Zhengwei Cai, Shuyun Zhang, Kun Wang, Lihua Li, Shan Ding, Changren Zhou
Liposome is one of a promising delivery system to improve water solubility, stability, and bioavailability of curcumin. But its instability is not favorable for long-circulating treatment, controlled release or conservation. To overcome the disadvantages, thiol derivatised chitosan (CSSH) were synthesized and utilized to coat liposomes. The CSSH coated curcumin liposomes (Cur-Lip-CSSH) had an encapsulation efficiency (EE) of 93.95%, a drug loading (DL) of 7.95%, an average particle size of 406.0nm, and a positive zeta-potential of 36...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865072/gallibacterium-elongation-factor-tu-possesses-amyloid-like-protein-characteristics-participates-in-cell-adhesion-and-is-present-in-biofilms
#18
Jaqueline López-Ochoa, J Fernando Montes-García, Candelario Vázquez, Patricia Sánchez-Alonso, Victor M Pérez-Márquez, Patrick J Blackall, Sergio Vaca, Erasmo Negrete-Abascal
Gallibacterium, which is a bacterial pathogen in chickens, can form biofilms. Amyloid proteins present in biofilms bind Congo red dye. The aim of this study was to characterize the cell-surface amyloid-like protein expressed in biofilms formed by Gallibacterium strains and determine the relationship between this protein and curli, which is an amyloid protein that is commonly expressed by members of the Enterobacteriaceae family. The presence of amyloid-like proteins in outer membrane protein samples from three strains of G...
September 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28861072/uropathogenic-escherichia-coli-upec-infections-virulence-factors-bladder-responses-antibiotic-and-non-antibiotic-antimicrobial-strategies
#19
REVIEW
Maria E Terlizzi, Giorgio Gribaudo, Massimo E Maffei
Urinary tract infections (UTIs) are one of the most common pathological conditions in both community and hospital settings. It has been estimated that about 150 million people worldwide develop UTI each year, with high social costs in terms of hospitalizations and medical expenses. Among the common uropathogens associated to UTIs development, UroPathogenic Escherichia coli (UPEC) is the primary cause. UPEC strains possess a plethora of both structural (as fimbriae, pili, curli, flagella) and secreted (toxins, iron-acquisition systems) virulence factors that contribute to their capacity to cause disease, although the ability to adhere to host epithelial cells in the urinary tract represents the most important determinant of pathogenicity...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28860764/liposomal-curcumin-and-its-application-in-cancer
#20
REVIEW
Ting Feng, Yumeng Wei, Robert J Lee, Ling Zhao
Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers...
2017: International Journal of Nanomedicine
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