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https://www.readbyqxmd.com/read/29340361/a-curcumin-loaded-polymeric-micelle-as-a-carrier-of-a-microrna-21-antisense-oligonucleotide-for-enhanced-anti-tumor-effects-in-a-glioblastoma-animal-model
#1
Xiaonan Tan, Gyeungyun Kim, Dahee Lee, Jungju Oh, Minkyung Kim, Chunxian Piao, Jaewon Lee, Min Sang Lee, Ji Hoon Jeong, Minhyung Lee
A glioblastoma is a common primary brain tumor that expresses microRNA-21 (miR-21), which inhibits the expression of pro-apoptotic genes such as phosphatase and tensin homologue (PTEN) and programmed cell death 4 (PDCD4). Therefore, an antisense-oligonucleotide against miR-21 (miR21ASO) could have therapeutic effects for glioblastomas. In this study, curcumin was loaded into deoxycholic acid-conjugated polyethylenimine (DP) micelles. The curcumin-loaded DP micelle (DP-Cur) was evaluated as a carrier for the combined delivery of curcumin and miR21ASO...
January 17, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29339268/incidence-of-second-primary-malignancies-after-autologous-transplantion-for-multiple-myeloma-in-the-era-of-novel-agents
#2
Firoozeh Sahebi, Simona Iacobelli, Giulia Sbianchi, Linda Koster, Didier Blaise, Péter Reményi, Nigel H Russell, Per Ljungman, Guido Kobbe, Jane Apperley, Marek Trneny, Marta Krejci, Wieslaw Wiktor-Jedrzejczak, James F Sanchez, Nicolaas Schaap, Cecilia Isaksson, Stig Lenhoff, Paul Browne, Christof Scheid, Keith M O Wilson, Ibrahim Yakoub-Agha, Soledad González Muñiz, Stefan Schönland, Curly Morris, Laurent Garderet, Nicolaus Kröger
The advent of novel agents for multiple myeloma (MM) is cause for a re-examination of the incidence of second primary malignancies (SPM). We examined the SPM rate in MM patients who were enrolled in the prospective observational Collaboration to Collect Autologous Transplant outcome in Lymphoma and Myeloma (CALM) study. Between 2008 and 2012, 3204 patients with MM underwent a first autologous hematopoietic stem cell transplantation (auto-HSCT). Plerixafor was used as a mobilizing agent for patients with poor (or potentially poor) stem cell mobilization as defined by the respective centers...
January 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29334109/a-multifunctional-supramolecular-hydrogel-preparation-properties-and-molecular-assembly
#3
Lin Wang, Xuefeng Shi, Yaqian Wu, Jian Zhang, Yuejun Zhu, Jinben Wang
A novel supramolecular hydrogel was designed and constructed by molecular self-assembly of a cationic gemini surfactant, 1,3-bis(N,N-dimethyl-N-cetylammonium)-2-propylacrylate dibromide (AGC16), and an anionic aromatic compound, trisodium 1,3,6-naphthalenetrisulfonate (NTS). Owing to its unique structure, the hydrogel (abbreviated as AGC16/NTS) has the potential to be used as a multifunctional drug delivery system. The structure and properties of AGC16/NTS were characterized by rheological measurements, differential scanning calorimetry, variable-temperature 1H nuclear magnetic resonance, ultraviolet-visible spectroscopy, variable-temperature fluorescence emission spectroscopy, cryogenic scanning electron microscopy, transmission electron microscopy and X-ray diffraction methods...
January 15, 2018: Soft Matter
https://www.readbyqxmd.com/read/29332034/microhemodynamic-indices-to-evaluate-the-effectiveness-of-herbal-medicine-in-diabetes-a-comparison-between-alpha-mangostin-and-curcumin-in-the-retina-of-type-2-diabetic-rats
#4
Amporn Jariyapongskul, Chonticha Areebambud, Niimi Hideyuki
OBJECTIVE: This study was aimed to develop microhemodynamic indices to evaluate the effectiveness of herbal medicine in diabetic tissues. METHODS: Male Sprague-Dawley rats were divided into four groups: normal control rats (Control), type 2 diabetic rats without (DM2) and with supplementation of alpha mangostin (DM2-MG) or curcumin (DM2-CUR). Alpha-mangostin or curcumin (200 mg/kg BW) were fed followed by i.p. injection of streptozotocin (STZ). Mean arterial pressure (MAP) and retinal blood flow (RBF) were measured and retinal flow resistance (RFR) was calculated...
January 10, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29330200/pwwp-domain-interactor-of-polycombs11-interacts-with-polycomb-group-proteins-and-histones-and-regulates-arabidopsis-flowering-and-development
#5
Mareike L Hohenstatt, Pawel Mikulski, Olga Komarynets, Constanze Klose, Ina Kycia, Albert Jeltsch, Sara Farrona, Daniel Schubert
Polycomb-group (PcG) proteins mediate epigenetic gene regulation by setting H3K27me3 via Polycomb Repressive Complex 2 (PRC2). In plants, it is largely unclear how PcG proteins are recruited to their target genes. Here, we identified the PWWP-DOMAIN INTERACTOR OF POLYCOMBS1 (PWO1) protein, which interacts with all three Arabidopsis thaliana PRC2 histone methyltransferases and is required for maintaining full H3 occupancy at several Arabidopsis genes. PWO1 localizes and recruits CURLY LEAF to nuclear speckles in Nicotiana benthamiana nuclei, suggesting a role in spatial organization of PcG regulation...
January 12, 2018: Plant Cell
https://www.readbyqxmd.com/read/29323877/curcumin-conjugated-gold-clusters-for-bioimaging-and-anticancer-applications
#6
Saravanan Govindaraju, Arunkumar Rengaraj, Roshini Arivazhagan, Yun-Suk Huh, Kyusik Yun
Curcumin-conjugated gold clusters (CUR-AuNCs) were synthesized using a "green" procedure and utilized as an anticancer and a bioimaging agent. Curcumin is a well-known anticancer agent, which forms a cluster when reacting with a gold precursor under mild alkali condition. A fluorescence spectroscopy analysis showed that the CUR-AuNCs emitted red fluorescence (650 nm) upon visible light (550) irradiation. Fourier transform infrared spectroscopy analysis confirmed the stretching and bending nature between the gold atoms and curcumin...
January 11, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29322140/development-of-antioxidant-gliadin-particle-stabilized-pickering-high-internal-phase-emulsions-hipes-as-oral-delivery-systems-and-the-in-vitro-digestion-fate
#7
F Z Zhou, T Zeng, S W Yin, C H Tang, D B Yuan, X Q Yang
In this paper, we demonstrate for the first time the use of gliadin particles to structure algal oil (rich in DHA) and to exert chemical stability against lipid oxidation via the Pickering high internal phase emulsion (HIPE) strategy. The gliadin/chitosan colloid particles (GCCPs) were effectively adsorbed and anchored at the algal oil-water interface. Concomitantly, the particle-coated droplets as building blocks constructed a percolating 3D-network framework, endowing Pickering HIPEs with viscoelastic and self-supporting attributes...
January 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29321305/arabidopsis-rna-polymerase-v-mediates-enhanced-compaction-and-silencing-of-geminivirus-and-transposon-chromatin-during-host-recovery-from-infection
#8
Tami Coursey, Elizabeth Regedanz, David M Bisaro
Plants employ RNA-directed DNA methylation (RdDM) and dimethylation of histone 3 lysine 9 (H3K9me2) to silence geminiviruses and transposable elements (TEs). We previously showed that canonical RdDM (Pol IV-RdDM) involving RNA polymerases IV and V (Pol IV and Pol V) is required for Arabidopsis thaliana to recover from infection with Beet curly top virus lacking a suppressor protein that inhibits methylation (BCTV L2-). Recovery, which is characterized by reduced viral DNA levels and symptom remission, allows normal floral development...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29320951/glutathione-conjugated-polyethylenimine-on-the-surface-of-fe3o4-magnetic-nanoparticles-as-a-theranostic-agent-for-targeted-and-controlled-curcumin-delivery
#9
Navid Aeineh, Fahimeh Salehi, Mohammad Akrami, Firouzeh Nemati, Masoumeh Alipour, Milad Ghorbani, Banafsheh Nikfar, Fatemeh Salehian, Nader Riyahi Alam, Seyed Esmaeil Sadat Ebrahimi, Alireza Foroumadi, Mehdi Khoobi, Mohammadreza Rouini, Maryam Dibaei, Ismaeil Haririan, Mohammad Reza Ganjali, Saeed Safaei
Theranostics with the ability to simultaneous monitoring of treatment progress and controlled delivery of therapeutic agents has become as an emerging therapeutic paradigm in cancer therapy. In this study, we have developed a novel surface functionalized iron oxide nanoparticle using polyethyleneimine (PEI) and glutathione (GSH) for targeted curcumin (CUR) delivery and acceptable pH sensitive character. The developed magnetic nanoparticles (MNPs) were physicochemically characterized by FT-IR, XRD, FE-SEM and TEM...
January 11, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29315234/curcumin-artemisinin-coamorphous-solid-xenograft-model-preclinical-study
#10
M K Chaitanya Mannava, Kuthuru Suresh, Manish Kumar Bommaka, Durga Bhavani Konga, Ashwini Nangia
Curcumin is a natural compound present in Indian spice turmeric. It has diverse pharmacological action but low oral solubility and bioavailability continue to limit its use as a drug. With the aim of improving the bioavailability of Curcumin (CUR), we evaluated Curcumin-Pyrogallol (CUR-PYR) cocrystal and Curcumin-Artemisinin (CUR-ART) coamorphous solid. Both of these solid forms exhibited superior dissolution and pharmacokinetic behavior compared to pure CUR, which is practically insoluble in water. CUR-ART coamorphous solid showed two fold higher bioavailability than CUR-PYR cocrystal (at 200 mg/kg oral dose)...
January 9, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29314414/an-ortholog-of-curly-leaf-enhancer-of-zeste-like-1-is-required-for-proper-flowering-in-brachypodium-distachyon
#11
Aaron Lomax, Daniel P Woods, Yinxin Dong, Frédéric Bouché, Ying Rong, Kevin S Mayer, Xuehua Zhong, Richard M Amasino
Many plants require prolonged cold exposure to acquire the competence to flower. The process by which cold exposure results in competence is known as vernalization. In Arabidopsis thaliana, vernalization leads to the stable repression of the floral repressor FLOWERING LOCUS C via chromatin modification including an increase of trimethylation on lysine 27 of histone H3 (H3K27me3) by Polycomb Repressive Complex 2 (PRC2). Vernalization in pooids is associated with the stable induction of a floral promoter, VERNALIZATION 1...
January 4, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29310081/bovine-serum-albumin-bsa-coated-iron-oxide-magnetic-nanoparticles-as-biocompatible-carriers-for-curcumin-anticancer-drug
#12
Hamed Nosrati, Naser Sefidi, Ali Sharafi, Hossein Danafar, Hamidreza Kheiri Manjili
The bovine serum albumin-coated magnetic nanoparticles (F@BSA NPs) were prepared as curcumin (CUR) carriers through desolvation and chemical co-precipitation process. The characteristics of CUR loaded F@BSA NPs (F@BSA@CUR NPs) were determined by X-ray diffraction (XRD), thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and vibrating-sampling magnetometry (VSM) techniques. It was found that the synthesized F@BSA@CUR NPs were spherical in shape with an average size of 56 ± 11...
January 2, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29309874/a-trade-off-between-solubility-enhancement-and-physical-stability-upon-simultaneous-amorphization-and-nanonization-of-curcumin-in-comparison-to-amorphization-alone
#13
Jerome Jie Long Wong, Hong Yu, Li Ming Lim, Kunn Hadinoto
The numerous health benefits of curcumin (CUR) have not been fully realized due to its low aqueous solubility, resulting in poor bioavailability. While amorphization of CUR via amorphous solid dispersion (ASD) represents a well-established CUR solubility enhancement strategy, simultaneous amorphization and nanonization of CUR via amorphous CUR nanoparticles (or nano-CUR in short) have emerged only recently as the plausibly superior alternative to ASD. Herein we examined for the first time the amorphous nano-CUR versus the ASD of CUR in terms of their (1) in vitro solubility enhancement capability and (2) long-term physical stability...
January 5, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29308689/iodinated-curcumin-bearing-dermal-cream-augmented-drug-delivery-antimicrobial-and-antioxidant-activities
#14
Gagandeep Manchanda, Rupinder Kaur Sodhi, Upendra Kumar Jain, Ramesh Chandra, Jitender Madan
OBJECTIVES: Curcumin (Cur) exhibits weak microbicidal activity owing to high lipophilicity and low cell permeability. Therefore, in present investigation, Cur was iodinated using elemental iodine (I2) to synthesize Cur-I2 powder that later formulated as Cur-I2 dermal cream and characterized in vitro for antimicrobial and antioxidant activities. METHODS AND RESULTS: Electrophilic addition of I2 saturated the olefinic bonds of Cur, as confirmed by UV/Visible spectroscopy, FT-IR, 1H NMR and DSC techniques...
January 6, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29307805/mannose-conjugated-curcumin-chitosan-nanoparticles-efficacy-and-toxicity-assessments-against-leishmania-donovani
#15
Pramila Chaubey, Brahmeshwar Mishra, Shyam Lal Mudavath, Ravi R Patel, Sundeep Chaurasia, Shyam Sundar, Vasanti Suvarna, Marvis Monteiro
Aim was to fabricate and optimize CUR-loaded mannose-functionalized chitosan nanoparticles (Cur-MCN) which overcome the limitations of drugs to reach the intracellular locations and to establish its therapeutic potential in visceral leishmaniasis by targeting of CUR to macrophages. Cur-MCN were developed by mannose-conjugated chitosan and have been tested for their efficacy and toxicit. In vivo antileishmanial activity in hamsters has shown significantly greater suppression of parasite replication in the spleen with Cur-MCN than unconjugated chitosan nanoparticles...
January 4, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29307181/smart-drug-delivery-system-inspired-enzyme-linked-immunosorbent-assay-based-on-fret-and-allochroic-effect-induced-dual-modal-colorimetric-and-fluorescent-detection
#16
Luyang Miao, Chengzhou Zhu, Lei Jiao, He Li, Dan Du, Yuehe Lin, Qin Wei
Numerous analytical techniques have been undertaken for the detection of protein biomarkers due to their extensive and significant applications in clinical diagnosis, whereas there are few strategies to develop dual-readout immunosensors to achieve more accurate results. To the best of our knowledge, inspired by smart drug delivery system (DDS), a novel pH- responsive modified enzyme-linked immunosorbent assay (ELISA) was innovatively developed for the first time, realizing dual-modal colorimetric and fluorescent detection of cardiac troponin I (cTnI)...
January 8, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29302995/preparation-of-curcumin-self-micelle-solid-dispersion-with-enhanced-bioavailability-and-cytotoxic-activity-by-mechanochemistry
#17
Qihong Zhang, Nikolay E Polyakov, Yulia S Chistyachenko, Mikhail V Khvostov, Tatjana S Frolova, Tatjana G Tolstikova, Alexandr V Dushkin, Weike Su
An amorphous solid dispersion (SD) of curcumin (Cur) with disodium glycyrrhizin (Na2GA) was prepared by mechanical ball milling. Curcumin loaded micelles were self-formed by Na2GA when SD dissolved in water. The physical properties of Cur SD in solid state were characterized by differential scanning calorimetry, X-ray diffraction studies, and scanning electron microscope. The characteristics of the sample solutions were analyzed by reverse phase HPLC, UV-visible spectroscopy, 1H NMR spectroscopy, gel permeation LC, and transmission electron microscopy...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29301415/ph-sensitive-polymeric-nanoparticles-of-mpeg-plga-pglu-with-hybrid-core-for-simultaneous-encapsulation-of-curcumin-and-doxorubicin-to-kill-the-heterogeneous-tumour-cells-in-breast-cancer
#18
Jian-Dong Yuan, De-Li ZhuGe, Meng-Qi Tong, Meng-Ting Lin, Xia-Fang Xu, Xing Tang, Ying-Zheng Zhao, He-Lin Xu
Most breast tumours are heterogeneous and not only contain the bulk of differentiated tumour cells but also a small population of highly tumorigenic and intrinsically drug-resistant cancer stem cells (CSCs). Herein, a pH-sensitive nanoparticle with simultaneous encapsulation of curcumin and doxorubicin (CURDOX-NPs) was prepared by using monomethoxy (polyethylene glycol)-b-P (D,L-lactic-co-glycolic acid)-b-P (L-glutamic acid) polymer to simultaneously target the differentiated tumor cells and CSCs. CURDOX-NPs had a mean diameter of 107...
January 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29288297/biomonitoring-of-polychlorinated-biphenyls-in-bavaria-germany-long-term-observations-and-standardization
#19
Roland Weber, Stefan Gonser, Jutta Köhler, Wolfgang Körner, Christine Herold, Roland Haag, Margit Krapp, Ludwig Peichl
In the 1980s, it was demonstrated that semi-volatile organic compounds (SVOCs) like polychlorinated biphenyls (PCBs) accumulate in plant leaves. Plants are at the base of the food chain, and therefore a starting point for transfer of PCBs to animals and related human exposure. For two decades, the Environment Agency of the German federal state of Bavaria (LfU) has been operating long-term monitoring stations to measure the impact of organic air pollutants. Standardized ryegrass, curly kale, and spruce needles are used as bioindicators for the atmospheric entries of PCBs into vegetation...
December 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29287782/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic-neurotransmission-and-consolidates-memory-in-male-rats
#20
Laraib Liaquat, Zehra Batool, Sadia Sadir, Sahar Rafiq, SidrahShahzad, Tahira Perveen, Saida Haider
AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress...
December 26, 2017: Life Sciences
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