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https://www.readbyqxmd.com/read/28234587/analysis-of-contributing-factors-influencing-thromboembolic-events-after-total-knee-arthroplasty
#1
Sylvie Plante, Etienne L Belzile, Dominique Fréchette, Jean Lefebvre
BACKGROUND: Venous thromboembolic events (VTE) are a known and well-described complication following total knee arthroplasty (TKA). We sought to validate the American College of Chest Physicians thromboprophylaxis recommendations after elective TKA, paying special attention to our dose adjustments for weight, and their impact on VTE in our population. METHODS: We retrospectively investigated risk factors in patients undergoing TKA, focusing mainly on symptomatic VTE occurrence rates from deep vein thrombosis (DVT) or pulmonary embolism (PE)...
February 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28234225/analysis-of-contributing-factors-influencing-thromboembolic-events-after-total-knee-arthroplasty
#2
Sylvie Plante, Etienne L Belzile, Dominique Fréchette, Jean Lefebvre
BACKGROUND: Venous thromboembolic events (VTE) are a known and well-described complication following total knee arthroplasty (TKA). We sought to validate the American College of Chest Physicians thromboprophylaxis recommendations after elective TKA, paying special attention to our dose adjustments for weight, and their impact on VTE in our population. METHODS: We retrospectively investigated risk factors in patients undergoing TKA, focusing mainly on symptomatic VTE occurrence rates from deep vein thrombosis (DVT) or pulmonary embolism (PE)...
December 1, 2016: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28234180/postoperative-anticoagulants-in-preventing-portal-vein-thrombosis-in-patients-undergoing-splenectomy-because-of-liver-cirrhosis-a-meta-analysis
#3
Jian-Ying Zhang, Yun-Bing Wang, Jian-Ping Gong, Fan Zhang, Yong Zhao
Portal vein thrombosis (PVT) frequently occurs in patients undergoing splenectomy because of liver cirrhosis. Whether the use of postoperative anticoagulants can decrease the incidence of PVT in these subjects is inconclusive. Moreover, the safety of the use of postoperative anticoagulants in the aforementioned patients is a concern. This meta-analysis aims to explore the effectiveness and safety of the preventive anticoagulants to prevent PVT in patients undergoing splenectomy because of liver cirrhosis. Four English language databases (i...
December 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28233825/optical-coherence-tomography-evaluation-of-pulmonary-arterial-vasculopathy-in-systemic-sclerosis
#4
Johannes P Schwaiger, Christopher D Loder, David Dobarro, Thomas Kaier, Sally Reddecliffe, Benjamin E Schreiber, Clive Handler, Christopher P Denton, John G Coghlan
Our current understanding of the pathophysiology of pulmonary vascular disease is incomplete, since information about alterations of the pulmonary vasculature in pulmonary arterial hypertension (PAH) is primarily provided by autopsy or tissue specimens. The aim of this study was to compare the distal pulmonary vasculature of <2 mm in diameter in Systemic Sclerosis (SSc) patients with (n = 17) and without (n = 5) associated PAH using Optical Coherence Tomography during Right Heart catheterization...
February 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28233629/trends-in-the-incidence-and-prevalence-of-atrial-fibrillation-and-estimated-thromboembolic-risk-using-the-cha2ds2-vasc-score-in-the-entire-korean-population
#5
So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Myung-Jin Cha, Seil Oh
BACKGROUND: Data on the epidemiology of atrial fibrillation (AF) and temporal trends are not well established in the Korean population. We aimed to estimate the incidence and prevalence of AF in Korea between 2008 and 2015. METHODS: Using the National Health Insurance Service database, we analyzed as a nationwide cohort the entire Korean adult population from 2008 to 2015 (n=41,505,679 in 2015). AF was identified by using diagnostic codes. RESULTS: During an 8-year period representing 314,311,360 person-years of follow-up, 496,341 individuals were newly diagnosed with AF...
February 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28233421/burden-of-hospitalizations-related-to-adverse-drug-events-in-the-usa-a-retrospective-analysis-from-large-inpatient-database
#6
Dilli Ram Poudel, Prakash Acharya, Sushil Ghimire, Rashmi Dhital, Rajani Bharati
PURPOSE: Adverse drug events (ADEs) represent medication-related patient harm, which is associated with significant patient morbidity and mortality. This study was conducted to determine the rate, specific causes, and outcomes of ADE-related hospitalization in the USA. METHODS: We used the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample dataset for the years 2008 to 2011. We selected patients with ADE based on 537 Classification of Diseases-9 codes...
February 24, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28233319/the-impact-of-bowl-size-program-setup-and-blood-hematocrit-on-the-performance-of-a-discontinuous-autotransfusion-system
#7
Timo F Seyfried, Michael Gruber, Fabian Streithoff, Robert J Mandle, Michael T Pawlik, Hendrik Busse, Ernil Hansen
BACKGROUND: Cell salvage is an essential element in the concept of blood management. Modern devices provide different bowl sizes and sensor-directed programs to optimally adjust to varying clinical situations. STUDY DESIGN AND METHODS: In an experimental performance study, the discontinuous autotransfusion device XTRA (LivaNova/Sorin) was evaluated using fresh donor blood anticoagulated with heparin 5 U/mL and adjusted to a hematocrit of 10% or 25%, representing orthopedic or cardiac surgery...
February 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28233177/anticoagulation-therapy-and-noacs-in-heart-failure
#8
Isac Thomas, Jorge EncisoSilva, Michelle Schlueter, Barry Greenberg
Current evidence indicates that heart failure (HF) confers a hyper-coagulable state that is associated with adverse events including stroke, systemic embolism, and mortality. This may be due to the elevated levels of pro-thrombotic and pro-inflammatory cytokines that are seen in patients with acute and chronic HF. Left ventricular wall motion abnormalities in patients with systolic dysfunction predispose to local thrombosis due to blood stasis as does atrial fibrillation (AF) which leads to blood stasis in regions of the atria...
February 24, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28233168/evaluating-cardioversion-outcomes-for-atrial-fibrillation-on-novel-oral-anticoagulants-versus-warfarin-experience-at-a-tertiary-referral-centre
#9
Z Sharif, B Srinivas, I Tiedt, N Ryan, M Awadalla, V Sullivan, D P Foley, T Gumbrielle, B McAdam, R G Sheahan
BACKGROUND: Current guidelines recommend anticoagulation prior to cardioversion in patients with atrial fibrillation of >48 h or unknown duration to reduce thromboembolic risk. Therapeutic anticoagulation with warfarin, with INR between 2 and 3, is consistently achieved in approximately 60% of patients. AIMS: We evaluated outcomes and assessed differences in direct current cardioversion (DCCV) in patients treated with warfarin and novel oral anticoagulants (NOAC) at our institution...
February 24, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28233091/effects-on-bone-metabolism-markers-and-arterial-stiffness-by-switching-to-rivaroxaban-from-warfarin-in-patients-with-atrial-fibrillation
#10
Sayaka Namba, Minako Yamaoka-Tojo, Ryota Kakizaki, Teruyoshi Nemoto, Kazuhiro Fujiyoshi, Takehiro Hashikata, Lisa Kitasato, Takuya Hashimoto, Ryo Kameda, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ako
In recent years, direct oral anticoagulants (DOACs) of dabigatran, rivaroxaban, apixaban, edoxaban, which are all alternatives to warfarin, have been released. The use of DOACs is becoming more widespread in the clinical management of thrombotic stroke risk in patients with atrial fibrillation (AF). In large-scale clinical trials of each drug, DOACs were reported to inhibit intracranial hemorrhage, stroke, and death compared to warfarin. Warfarin is an endogenous vitamin K antagonist; therefore, patients who are taking warfarin must be prohibited from taking vitamin K...
February 23, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28233037/-management-of-acute-coronary-syndrome-without-st-segment-elevation
#11
C Liebetrau, C W Hamm
Acute coronary syndrome without persistent ST-segment elevation (non-ST segment elevation myocardial infarction and instable angina pectoris NSTEMI-ACS) is common and is associated with a high mortality. In addition to 12-channel echocardiograph (ECG) assessment, measurement of cardiac troponins I and T are important for risk stratification and diagnosis. The introduction of high-sensitivity cardiac troponin assays and their implementation into clinical practice has influenced risk stratification and treatment of these patients...
February 23, 2017: Herz
https://www.readbyqxmd.com/read/28232717/managing-direct-oral-anticoagulants-in-patients-undergoing-dentoalveolar-surgery
#12
J P Patel, S A Woolcombe, R K Patel, O Obisesan, L N Roberts, C Bryant, R Arya
Our objective was to describe our experience of managing a cohort of adult patients prescribed direct oral anticoagulants (DOACs) undergoing dentoalveolar procedures between November 2012 and May 2016. Prior to conducting a procedure a formal assessment was made of each patient's anticoagulation treatment. A specific plan was then formulated, balancing the risk of bleeding with the risk of thrombosis. Patients received a telephone consultation one week following treatment to assess any post-operative bleeding...
February 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28232697/anticoagulants-lack-of-research
#13
F McDonnell
No abstract text is available yet for this article.
February 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28232641/atrial-fibrillation-patients-who-sustained-warfarin-associated-intracerebral-haemorrhage-have-poor-neurological-outcomes-results-from-a-matched-case-series
#14
M K Fong, B Sheng, Y P Chu, W T Wong, P Pk Lau, H Y Wong, K K Lau
INTRODUCTION: Coagulopathy-associated intracerebral haemorrhage has become increasingly common because of the rising demand in the ageing population for anticoagulation for atrial fibrillation. This study compared the clinical features and neurological outcomes of intracerebral haemorrhage in patients with atrial fibrillation who were prescribed warfarin with those who were not. METHODS: This was a retrospective matched case series of patients with intracerebral haemorrhage from three tertiary hospitals in Hong Kong from 1 January 2006 to 31 December 2011...
February 24, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28232327/apixaban-versus-warfarin-for-mechanical-heart-valve-thromboprophylaxis-in-a-swine-aortic-heterotopic-valve-model
#15
Patrick A Lester, Dawn M Coleman, Jose A Diaz, Tatum O Jackson, Angela E Hawley, Angela R Mathues, Brandon T Grant, Robert M Knabb, Eduardo Ramacciotti, Charles E Frost, Yan Song, Thomas W Wakefield, Daniel D Myers
OBJECTIVE: Warfarin is the current standard for oral anticoagulation therapy in patients with mechanical heart valves, yet optimal therapy to maximize anticoagulation and minimize bleeding complications requires routine coagulation monitoring, possible dietary restrictions, and drug interaction monitoring. As alternatives to warfarin, oral direct acting factor Xa inhibitors are currently approved for the prophylaxis and treatment of venous thromboembolism and reduction of stroke and systemic embolization...
February 23, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28231906/bioprosthetic-heart-valves-thrombosis-anticoagulation-and-imaging-surveillance
#16
EDITORIAL
Jeroen J Bax, Victoria Delgado
No abstract text is available yet for this article.
February 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28231905/outcomes-of-warfarin-therapy-for-bioprosthetic-valve-thrombosis-of-surgically-implanted-valves-a-prospective-study
#17
Alexander C Egbe, Heidi M Connolly, Patricia A Pellikka, Hartzell V Schaff, Richard Hanna, Joseph J Maleszewski, Vuyisile T Nkomo, Sorin V Pislaru
OBJECTIVES: The aim of this study was to assess the efficacy of warfarin in the treatment of bioprosthetic valve thrombosis (BPVT) of surgically implanted valves. BACKGROUND: There are limited data about treatment outcomes for BPVT. METHODS: This was a prospective study of patients with suspected BPVT of surgically implanted valves who received warfarin therapy at the Mayo Clinic from January 2013 to January 2016. BPVT score was calculated using previously described echocardiographic criteria...
February 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28230634/platelet-dysfunction-in-critically-ill-patients
#18
Travis Hase, Sarah Sirajuddin, Patrick Maluso, Raksha Bangalore, Louis DePalma, Babak Sarani
Thrombelastography Platelet Mapping (TEG-PM) allows for measurement of maximal potential clot strength (MA) and strength from stimulation of arachidonic acid (MA-AA) and adenosine disphosphate (MA-ADP) receptors. This study was conducted to assess degree of platelet dysfunction in critically ill adult patients. A retrospective study of critically ill, adult, nontrauma patients in a medical/surgical ICU was conducted from August 2013 to September 2014. All patients who underwent TEG-PM were enrolled. Patients with intracerebral hemorrhage, following cardiac surgery, or without an APACHE II score were excluded...
February 21, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28230262/evaluation-of-the-immunogenicity-of-the-dabigatran-reversal-agent-idarucizumab-during-phase-i-studies
#19
Stephen Norris, Steven Ramael, Ippei Ikushima, Wouter Haazen, Akiko Harada, Viktoria Moschetti, Susumu Imazu, Paul A Reilly, Benjamin Lang, Joachim Stangier, Stephan Glund
AIMS: Idarucizumab, a humanized monoclonal anti-dabigatran antibody fragment, is effective in emergency reversal of dabigatran anticoagulation. Pre-existing and treatment-emergent anti-idarucizumab antibodies (antidrug antibodies; ADA) may affect the safety and efficacy of idarucizumab. This analysis characterized the pre-existing and treatment-emergent ADA and assessed their impact on the pharmacokinetics and pharmacodynamics (PK/PD) of idarucizumab. METHODS: Data were pooled from three phase I, randomized, double-blind idarucizumab studies in healthy Caucasian; elderly, renally impaired subjects; and healthy Japanese subjects...
February 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28230176/antithrombotic-therapy-for-patients-with-stemi-undergoing-primary-pci
#20
REVIEW
Francesco Franchi, Fabiana Rollini, Dominick J Angiolillo
Antithrombotic therapy, including antiplatelet and anticoagulant agents, is the cornerstone of pharmacological treatment to optimize clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Intravenous anticoagulant drugs available for PPCI include the indirect thrombin inhibitors unfractionated heparin and low-molecular-weight heparin, and the direct thrombin inhibitor bivalirudin. Intravenous antiplatelet drugs mainly include glycoprotein IIb/IIIa inhibitors and the P2Y12-receptor inhibitor cangrelor...
February 23, 2017: Nature Reviews. Cardiology
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