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https://www.readbyqxmd.com/read/29691992/breastfeeding-and-growth-during-infancy-among-offspring-of-mothers-with-gestational-diabetes-mellitus-a-prospective-cohort-study
#1
E P Gunderson, L C Greenspan, M S Faith, S R Hurston, C P Quesenberry
BACKGROUND: Breastfeeding (BF) may protect against obesity and type 2 diabetes mellitus in children exposed to maternal diabetes in utero, but its effects on infant growth among this high-risk group have rarely been evaluated. OBJECTIVES: The objective of this study was to evaluate BF intensity and duration in relation to infant growth from birth through 12 months among offspring of mothers with gestational diabetes mellitus (GDM). METHODS: Prospective cohort of 464 GDM mother-infant dyads (28% White, 36% Hispanic, 26% Asian, 8% Black, 2% other)...
April 24, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29691908/expression-of-cutaneous-immunity-markers-during-infant-skin-maturation
#2
Frank Kirchner, Kimberly A Capone, M Catherine Mack, Georgios N Stamatas
BACKGROUND/OBJECTIVES: Infant skin undergoes a maturation process during the early years of life. Little is known about the skin's innate immunity. We investigated the dynamics of innate immunity markers collected from the surface of infant skin during the first 36 months of life. METHODS: A total of 117 healthy infants aged 3-36 months participated in the study. We extracted human beta defensin-1 and interleukin 1 alpha and its receptor antagonist using transdermal analysis patches from the skin surface of the posterior lower leg area...
April 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29691886/cutaneous-langerhans-cell-histiocytosis-presenting-with-hypopigmented-lesions-report-of-two-cases-and-review-of-literature
#3
Shoko Mori, Tony Adar, Viktoryia Kazlouskaya, Jaime B Alexander, Edward Heilman, Sharon A Glick
Langerhans cell histiocytosis is a rare group of disorders that results from the abnormal proliferation and accumulation of dendritic-derived cells in various organs of the body, such as the skin and bones. Hypopigmented macules are a rare cutaneous presentation of Langerhans cell histiocytosis that may pose a diagnostic dilemma when no other findings of Langerhans cell histiocytosis are present at the time of examination. We present 2 cases of the hypopigmented variant of Langerhans cell histiocytosis, including a case with histopathologic features of regression, and a review of the literature...
April 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29691876/waking-up-too-early-the-consequences-of-preterm-birth-on-sleep-development
#4
Laura Bennet, David W Walker, Rosemary S C Horne
Good quality sleep of sufficient duration is vital for optimal physiological function and our health. Sleep deprivation is associated with impaired neurocognitive function and emotional control, and increases the risk for cardiometabolic diseases, obesity and cancer. Sleep develops during fetal life with the emergence of a recognisable pattern of sleep states in the preterm fetus associated with the development, maturation, and connectivity within neural networks in the brain. Despite the physiological importance of sleep, surprisingly little is known about how sleep develops in individuals born preterm...
April 24, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29691836/early-life-regional-and-temporal-variation-in-filaggrin-derived-natural-moisturising-factor-filaggrin-processing-enzyme-activity-corneocyte-phenotypes-and-plasmin-activity-implications-for-atopic-dermatitis
#5
M A McAleer, I Jakasa, N Raj, C P F O'Donnell, M E Lane, A V Rawlings, R Voegeli, W H I McLean, S Kezic, A D Irvine
BACKGROUND: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products (natural moisturising factors, NMF), activities of filaggrin processing enzymes (bleomycin hydrolase; BH and calpain-1; C-1) and plasmin, and corneocyte envelope (CE) maturity in early life are largely unknown. OBJECTIVES: We did a cross-sectional, observational study investigating regional and age dependent variations in NMF levels, activity of proteases and CE maturity in stratum corneum (SC) from infants to determine if these could explain the observed predilection sites for AD in early life...
April 25, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29691835/rufinamide-add-on-therapy-for-refractory-epilepsy
#6
REVIEW
Mariangela Panebianco, Hemanshu Prabhakar, Anthony G Marson
BACKGROUND: Epilepsy is a central nervous system disorder (neurological disorder). Epileptic seizures are the result of excessive and abnormal cortical nerve cell electrical activity in the brain. Despite the development of more than 10 new antiepileptic drugs (AEDs) since the early 2000s, approximately a third of people with epilepsy remain resistant to pharmacotherapy, often requiring treatment with a combination of AEDs. In this review, we summarised the current evidence regarding rufinamide, a novel anticonvulsant medication, which, as a triazole derivative, is structurally unrelated to any other currently used anticonvulsant medication, when used as an add-on treatment for refractory epilepsy...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29691363/detection-of-circulating-mycobacterium-tuberculosis-specific-dna-by-droplet-digital-pcr-for-vaccine-evaluation-in-challenged-monkeys-and-tb-diagnosis
#7
Neng Song, Yang Tan, Lingyun Zhang, Wei Luo, Qing Guan, Ming-Zhe Yan, Ruiqi Zuo, Weixiang Liu, Feng-Ling Luo, Xiao-Lian Zhang
Mycobacterium tuberculosis (M. tb) is emerging as a more serious pathogen due to the increased multidrug-resistant TB and co-infection of human immunodeficiency virus (HIV). The development of an effective and sensitive detection method is urgently needed for bacterial load evaluation in vaccine development, early TB diagnosis, and TB treatment. Droplet digital polymerase chain reaction (ddPCR) is a newly developed sensitive PCR method for the absolute quantification of nucleic acid concentrations. Here, we used ddPCR to quantify the circulating virulent M...
April 24, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29691284/a-modified-algorithm-for-critical-congenital-heart-disease-screening-using-pulse-oximetry
#8
Christina L Diller, Michael S Kelleman, Kenneth G Kupke, Sharon C Quary, Lazaros K Kochilas, Matthew E Oster
: media-1vid110.1542/5727212367001PEDS-VA_2017-4065 Video Abstract OBJECTIVES: Determine the performance of the American Academy of Pediatrics (AAP) critical congenital heart disease (CCHD) newborn screening algorithm and the impact of an alternative algorithm. METHODS: Screening was performed on term infants without a known CCHD diagnosis at or near 24 hours of age at a tertiary birth hospital by using the AAP algorithm from 2013 to 2016. Retrospective review from the birth hospital and the area's sole pediatric cardiac center identified true- and false-positives and true- and false-negatives...
April 24, 2018: Pediatrics
https://www.readbyqxmd.com/read/29691250/long-term-neuroprotective-effect-of-erythropoietin-on-executive-functions-in-very-preterm-children-epokids-protocol-of-a-prospective-follow-up-study
#9
Flavia Maria Wehrle, Ulrike Held, Ruth Tuura O'Gorman, Vera Disselhoff, Barbara Schnider, Jean-Claude Fauchère, Petra Hüppi, Beatrice Latal, Cornelia Franziska Hagmann
INTRODUCTION: Premature infants are particularly vulnerable to brain injuries with associated cognitive and behavioural deficits. The worldwide first randomised interventional multicentre trial investigating the neuroprotective effects of erythropoietin (entitled 'Does erythropoietin improve outcome in very preterm infants?' (NCT00413946)) included 450 very preterm infants in Switzerland. MRI at term equivalent age showed less white matter (WM) injury in the erythropoietin group compared with the placebo group...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29690948/successful-treatment-of-disseminated-adenovirus-infection-with-cidofovir-and-intravenous-immunoglobulin-in-an-infant-following-heart-transplant
#10
Ryan M Serrano, Robert K Darragh, John J Parent
For most patients, adenoviruses cause few acute health concerns and are often self-limiting. Patients who are immunocompromised or immunosuppressed, however, are at risk for disseminated adenovirus and suffer high morbidity and mortality, without well-defined treatment options. We report the case of a 9-month-old boy who was successfully treated for disseminated adenovirus infection with intravenous immunoglobulin and cidofovir 3 months post heart transplant, tailored to serum adenoviral load and clinical response...
April 25, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29690917/health-consequences-for-mother-and-baby-of-substantial-pre-conception-weight-loss-in-obese-women-study-protocol-for-a-randomized-controlled-trial
#11
Sarah Price, Alison Nankervis, Michael Permezel, Luke Prendergast, Priya Sumithran, Joseph Proietto
BACKGROUND: Current guidelines for the management of obesity in women planning pregnancy suggest lifestyle modification before conception. However, there is little evidence that lifestyle modification alters pregnancy outcomes. Bariatric surgery results in significant weight loss. This appears to reduce the risk of adverse pregnancy outcomes for the mother but may increase the risk of adverse outcomes for the infant. In order to reduce the risks of obesity-related adverse pregnancy outcomes for both mother and offspring, alternative approaches to the management of obesity in women planning pregnancy are needed...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29690871/association-of-food-security-status-with-overweight-and-dietary-intake-exploration-of-white-british-and-pakistani-origin-families-in-the-born-in-bradford-cohort
#12
T C Yang, P Sahota, K E Pickett, M Bryant
BACKGROUND: Food insecurity has been associated with dietary intake and weight status in UK adults and children although results have been mixed and ethnicity has not been explored. We aimed to compare prevalence and trajectories of weight and dietary intakes among food secure and insecure White British and Pakistani-origin families. METHODS: At 12 months postpartum, mothers in the Born in Bradford cohort completed a questionnaire on food security status and a food frequency questionnaire (FFQ) assessing their child's intake in the previous month; at 18 months postpartum, mothers completed a short-form FFQ assessing dietary intake in the previous 12 months...
April 24, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29690542/infant-feeding-attitudes-and-practices-of-spanish-low-risk-expectant-women-using-the-iifas-iowa-infant-feeding-attitude-scale
#13
María Del Carmen Suárez Cotelo, María Jesús Movilla-Fernández, Paula Pita-García, Silvia Novío
The Iowa Infant Feeding Attitude Scale (IIFAS) has been shown to have good psychometric properties for English-speaking populations, but it has not been validated among low-risk pregnant women in Spain. The aim of this study was to assess the reliability and validity of the translated version of the IIFAS in order to examine infant feeding attitudes in Spanish women with an uncomplicated pregnancy. Low-risk expectant women ( n = 297) were recruited from eight primary public health care centres in Galicia (Spain)...
April 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29689940/a-new-species-of-hyloscirtus-anura-hylidae-from-the-colombian-and-venezuelan-slopes-of-sierra-de-perij%C3%A3-and-the-phylogenetic-position-of-hyloscirtus-jahni-rivero-1961
#14
Fernando J M Rojas-Runjaic, Edwin E Infante-Rivero, Patricia E Salerno, Fabio Leonardo Meza-Joya
A new species of Hyloscirtus, belonging to the H. bogotensis species Group, is described from the Venezuelan and Colombian slopes of the Sierra de Perijá. The new species can be readily distinguished from its congeners by the combination of the following characters: mental gland present, disc-shaped and small; ulnar, outer, and inner tarsal folds present; calcar tubercle absent; whitish stripes on external border of upper eyelids and supratympanic folds, longitudinally on the mid-dorsum, on supracloacal fold, outer ulnar folds, inner and outer tarsal folds, and also on dorsal internal surface of shanks...
February 20, 2018: Zootaxa
https://www.readbyqxmd.com/read/29689751/effect-of-standardized-feeding-protocol-on-nutrient-supply-and-postnatal-growth-of-preterm-infants-a-prospective-study
#15
Z Khan, N Morris, H Unterrainer, N Haiden, S J Holasek, B Urlesberger
BACKGROUND: Preterm birth is a medical emergency and it is becoming evident that adequate nutrition starting in the first hours of life is of major importance for short and even more so for long-term health outcomes of the premature newborn. The aim was to analyze postnatal nutrient supply and growth patterns of preterm infants in response to a standardized feeding protocol during stay at neonatal intensive care unit (NICU). METHODS: A prospective cohort study was conducted at NICU, Children Hospital Graz...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689749/the-association-between-alcohol-outlet-accessibility-and-adverse-birth-outcomes-a-retrospective-cohort-study
#16
J A Seabrook, N Woods, A Clark, B de Vrijer, D Penava, J Gilliland
BACKGROUND: Alcohol outlet accessibility is positively associated with alcohol consumption, although this relationship has not been thoroughly examined in pregnant women. The present study examines the relationship between proximity and density of alcohol outlets and risk for low birth weight (LBW: <2,500 grams) and preterm birth (PTB: <37 weeks gestational age), and is the first Canadian study to investigate this association. METHODS: Maternal accessibility to alcohol outlets was specified using a gravity-type measure of accessibility, which provides the amount of accessibility that a given household has to liquor stores within 30-minutes of their home...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689748/probiotic-lactococcus-lactis-decreases-incidence-and-severity-of-necrotizing-enterocolitis-in-a-preterm-animal-model
#17
L A Gurien, K Stallings-Archer, S D Smith
BACKGROUND: Necrotizing enterocolitis (NEC) persists as the most common and serious gastrointestinal disorder among premature infants. Lactococcus lactis (LL), a lactic acid producing bacteria commonly found in buttermilk and cheese products, has several unique properties making it an ideal probiotic for neonates. We evaluated if the probiotic LL prevents development of NEC in a preterm rabbit model with Cronobacter sakazakii (CS). METHODS: Two-day preterm New Zealand white rabbit pups were randomly assigned to three diets: control (no additives), CS, and CS+LL...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689746/bereaved-mothers-and-fathers-perceptions-of-a-legacy-intervention-for-parents-of-infants-in-the-nicu
#18
T F Akard, M Duffy, A Hord, A Randall, A Sanders, K Adelstein, U E Anani, M J Gilmer
BACKGROUND: Legacy-making, actions or behaviors aimed at being remembered, may be one strategy to enhance coping and improve grief outcomes for bereaved parents and siblings. While legacy interventions have been developed and tested in pediatric and adult populations, legacy activities specific to bereaved parents in the neonatal intensive care unit remain unexplored. This study explored bereaved parents' perceptions of a digital storytelling legacy-making intervention for parents after the death of an infant...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689745/umbilical-cord-clamping-practices-of-u-s-obstetricians
#19
M S Leslie, J Greene, J Schulkin, A C Jelin
BACKGROUND: Delayed umbilical cord clamping is associated with significant benefits to preterm and term newborns and is recommended for all infants by the World Health Organization and the American College of Obstetricians and Gynecologists (ACOG). Little is known about the cord management practices of U.S. obstetricians. OBJECTIVE: The objective of this study was to describe current cord clamping practices by U.S. obstetricians and investigate factors associated with delayed cord clamping...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689743/extravasation-of-total-parenteral-nutrition-into-the-liver-from-an-upper-extremity-peripherally-inserted-central-venous-catheter
#20
Arpit Gupta, Alok Bhutada, Miheret Yitayew, Shantanu Rastogi
Peripherally inserted central catheters (PICC) are the mainstay of central venous access in preterm infants, and one of the common procedures performed in neonatal intensive care unit (NICU). Complications of PICC include infection, mechanical dysfunction, thrombosis, migration, and extravasation of the infusate. In this report, we describe a case of PICC inserted from an upper extremity with migration into the inferior vena cava (IVC) and the hepatic vein associated with extravasation of the total parenteral nutrition (TPN) into the peritoneum and the liver...
2018: Journal of Neonatal-perinatal Medicine
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