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https://www.readbyqxmd.com/read/29452380/relative-vaccine-effectiveness-of-high-dose-versus-standard-dose-influenza-vaccines-among-veterans-health-administration-patients
#1
Yinong Young-Xu, Robertus Van Aalst, Salaheddin M Mahmud, Kenneth J Rothman, Julia Thornton Snider, Daniel Westreich, Vincent Mor, Stefan Gravenstein, Jason K H Lee, Edward W Thommes, Michael D Decker, Ayman Chit
Background: To examine whether a high-dose inactivated influenza vaccine was more efficacious in preventing hospitalizations than a standard-dose vaccine in the Veterans Health Administration (VHA) senior population. Methods: This study estimated the relative vaccine effectiveness (rVE) of high-dose versus standard-dose using a retrospective cohort of VHA patients 65 years of age or older in the 2015-16 influenza season. To adjust for measured confounders, we matched each high-dose recipient with up to four standard-dose recipients vaccinated at the same location within a two-week period and having two or more pre-existing medical co-morbidities...
February 14, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29452372/impact-of-timing-of-influenza-vaccination-in-pregnancy-on-transplacental-antibody-transfer-influenza-incidence-and-birth-outcomes-a-randomized-trial-in-rural-nepal
#2
Joanne Katz, Janet A Englund, Mark C Steinhoff, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, James M Tielsch
Background: Maternal influenza vaccination protects mothers and their infants in low resource settings but little is known about whether the protection varies by gestational age at vaccination. Methods: Women of childbearing age in rural southern Nepal were surveilled for pregnancy, consented and randomized to receive maternal influenza vaccination or placebo, with randomization stratified on gestational age (17-25 or 26-34 weeks). Enrollment occurred in two annual cohorts and vaccinations occurred from April 2011 through September 2013...
February 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29452366/prevalence-and-incidence-of-anal-and-cervical-high-risk-human-papillomavirus-hpv-types-covered-by-current-hpv-vaccines-among-hiv-infected-women-in-the-study-to-understand-the-natural-history-of-hiv-aids-in-the-era-of-effective-therapy-the-sun-study
#3
Erna Milunka Kojic, Lois Conley, Tim Bush, Susan Cu-Uvin, Elizabeth R Unger, Keith Henry, John Hammer, Gerome Escota, Teresa M Darragh, Joel M Palefsky, John T Brooks, Pragna Patel
Background: Nonavalent (9v) human papilloma virus vaccine targets high-risk (HR)-HPV types 16, 18, 31, 33, 45, 52, 58, and low-risk 6, 11. We examined prevalence, incidence, and clearance of anal and cervical HR-HPV in HIV-infected women. Methods: From 2004-2006, the SUN Study enrolled 167 women from four US cities. Anal and cervical specimens were collected annually for cytology and identification of 37 HPV types; 14 HR include: 9v 16, 18, 31, 33, 45, 52, 58; non-9v 35, 39, 51, 56, 59, 66, 68...
February 14, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29452280/sticholysin-ii-mediated-cytotoxicity-involves-the-activation-of-regulated-intracellular-responses-that-anticipates-cell-death
#4
Carmen Soto, Gretchen Bergado, Rancés Blanco, Tania Griñán, Hermis Rodríguez, Uris Ros, Fabiola Pazos, María Eliana Lanio, Ana María Hernández, Carlos Álvarez
Sticholysin II (StII) is a pore-forming toxin of biomedical interest that belongs to the actinoporin protein family. Sticholysins are currently under examination as an active immunomodulating component of a vaccinal platform against tumoral cells and as a key element of a nucleic acids delivery system to cell cytosol. These proteins form pores in the plasma membrane leading to ion imbalance and cell lysis. However, the intracellular mechanisms triggered by actinoporins upon binding to membranes and its consequences for cell death are barely understood...
February 13, 2018: Biochimie
https://www.readbyqxmd.com/read/29452258/recent-findings-related-to-immune-responses-against-leptospirosis-and-novel-strategies-to-prevent-infection
#5
Frédérique Vernel-Pauillac, Catherine Werts
What are the new approaches and emerging ideas to prevent leptospirosis, a neglected bacterial re-emerging zoonotic disease? How do Leptospira interrogans escape the host defenses? We aim here to review and discuss the most recent literature that provides some answers to these questions, in particular data related to a better understanding of adaptive and innate immunity towards leptospires, and design of vaccines. This is an opinion paper, not a comprehensive review. We will try to highlight the new strategies and technologies boosting the search for drugs and vaccines...
February 13, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29452195/construction-and-evaluation-of-the-immune-protection-of-a-recombinant-divalent-protein-composed-of-the-mrpa-from-mr-p-fimbriae-and-flagellin-of-proteus-mirabilis-strain-against-urinary-tract-infection
#6
Mehri Habibi, Mohammad Reza Asadi Karam, Saeid Bouzari
Urinary tract infections (UTI) caused by Proteus mirabilis are prevalent among the catheterized patients. There is no effective vaccine to reduce the frequency of UTIs caused by P. mirabilis. In the present study, the immune responses and effectiveness of different combinations of MrpA and flagellin (FliC) of P. mirabilis were assessed intranasally in the mice model. The addition of FliC as adjuvant to MrpA in fusion form significantly raised the mucosal IgA and cellular (IFN-γ and IL-17) responses and maintained the serum IgG responses for 180 days after the first vaccination...
February 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29452143/unusual-self-assembly-of-the-recombinant-chlamydia-trachomatis-major-outer-membrane-protein-momp-based-fusion-antigen-cth522-into-protein-nanoparticles
#7
Fabrice Rose, Kasper Karlsen, Pernille Rønde Jensen, Rasmus Uffe Jakobsen, Grith Krøyer Wood, Kasper Dyrberg Rand, Helene Godiksen, Peter Andersen, Frank Follmann, Camilla Foged
Sexually transmitted Chlamydia trachomatis (Ct) infects more than 100 million people annually, and untreated chlamydia infections can cause severe complications. Therefore, there is an urgent need for a chlamydia vaccine. The Ct major outer membrane protein (MOMP) is highly immunogenic but is a challenging vaccine candidate by being an integral membrane protein, and the immunogenicity depends on a correctly folded structure. We investigated the biophysical properties of the recombinant MOMP-based fusion antigen CTH522, which is tested in early human clinical trials...
February 13, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29452111/recent-progress-in-drug-targets-and-inhibitors-towards-combating-leishmaniasis
#8
REVIEW
Vijayakumar Saravanan, Pradeep Das
Lesihmaniasis is one of the major neglected tropical disease caused by the parasite of the genus Leishmania. The disease has more than one clinical forms and the visceral form is considered fatal. With the lack of potential vaccine, chemotherapy is the major treatment source considered for the control of the disease in the infected people. Drugs including amphotericin B and miltefosine are widely used for the treatment, however, development of resistance by the parasite towards the administered drug and high-toxicity of the drug are of major concern...
February 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29452047/lessons-learned-from-ebola-vaccine-r-d-during-a-public-health-emergency
#9
Marie-Paule Kieny
In spite of a complete lack of Research and Development (R&D) preparedness, the 2013-2016 West-Africa Ebola experience demonstrated that it is possible to compress R&D timelines to less than a single year, from a more usual decade or longer. This is mostly to be credited to an unprecedented collaborative effort building on the availability of a small number of candidate diagnostic tests, drugs and vaccines that could be moved rapidly into the clinical phase evaluation. The World Health Organization (WHO) led international consultations and activities - including the organization of a successful Ebola vaccine efficacy trial in Guinea - as a contribution to the unprecedented global efforts to control the Ebola epidemic...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29452028/meningococcal-disease-and-vaccination-knowledge-and-acceptability-among-adolescents-in-italy
#10
Concetta Paola Pelullo, Francesco Napolitano, Gabriella Di Giuseppe
This study aimed to evaluate the knowledge, attitudes and practice about invasive meningococcal disease and the relative vaccine for adolescent in Italy. A cross-sectional study was conducted from March to May 2017 among a sample of 771 adolescents in the geographic area of Naples (Italy). A self-administered anonymous questionnaire was used to collect demographics, knowledge about meningitis and preventive measures, perceived risk for contracting meningitis, attitude towards the utility of meningococcal vaccine, and adolescents' willingness to receive a meningococcal vaccine...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29451878/control-fast-or-control-smart-when-should-invading-pathogens-be-controlled
#11
Robin N Thompson, Christopher A Gilligan, Nik J Cunniffe
The intuitive response to an invading pathogen is to start disease management as rapidly as possible, since this would be expected to minimise the future impacts of disease. However, since more spread data become available as an outbreak unfolds, processes underpinning pathogen transmission can almost always be characterised more precisely later in epidemics. This allows the future progression of any outbreak to be forecast more accurately, and so enables control interventions to be targeted more precisely...
February 16, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29451838/serotype-distribution-of-streptococcus-pneumoniae-and-potential-impact-of-pneumococcal-conjugate-vaccines-in-china-a-systematic-review-and-meta-analysis
#12
Kaile Chen, Xiyan Zhang, Wei Shan, Genming Zhao, Tao Zhang
OBJECTIVE: Thirteen-valent pneumococcal conjugate vaccines (PCV13) was licensed for optional use in mainland China since 2017, but the uptake is low. To update the research evidence for the pneumococcal serotype distribution of pre-PCV era and to estimate the potential impact of PCVs, we performed a meta-analysis on the relevant publications concerning the Chinese population. METHODS: This systematic review and meta-analysis were conducted on the pneumococcal serotype distribution publications in mainland China from 2000 to 2016...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29451834/influenza-vaccination-2014-2015-results-of-a-survey-conducted-among-general-practitioners-in-italy
#13
Miriam Levi, Paolo Bonanni, Marco Biffino, Michele Conversano, Maria Corongiu, Paolo Morato, Tommasa Maio
Introduction The aim of the present study was to evaluate orientation, organizational procedures implemented and difficulties faced by general practitioners (GPs) during the 2014/15 seasonal influenza vaccination programme, as well as GPs' general attitude towards vaccinations. Methods An ad hoc online survey was developed and administered to general practitioners members of the Italian Federation of GPs (Federazione Italiana Medici di Medicina Generale - FIMMG). Overall, 10,000 survey invitations were sent...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29451833/development-and-pilot-testing-of-a-text-message-vaccine-reminder-system-for-use-during-an-influenza-pandemic
#14
Jonathan D Lehnert, Alex Shevach, Sydney Walker, Rose Wang, Thomas J Fitzgerald, Samuel B Graitcer
In an influenza pandemic, two vaccine doses administered 21 days apart may be needed for individuals of all ages to achieve seroprotection. Achieving dose-series completion can be challenging even for routinely recommended vaccines. To prepare for a two-dose influenza pandemic vaccine campaign and promote dose-series completion and correct dosing intervals, CDC and its partners developed a text message-based vaccine reminder system to remind persons who receive a first dose of pandemic influenza vaccine to receive the second dose...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29451634/-varicella-and-herpes-zoster-challenges-for-public-health
#15
Mirella Vázquez, Patricia Cravioto, Fernando Galván, Diana Guarneros, Víctor Hugo Pastor
OBJECTIVE: To evaluate the epidemiological behavior of varicella and herpes zoster (HZ) to determine the need of health policies to diminish prevalence and avoid complications. MATERIALS AND METHODS: To assess frequency, we analyzed data from the National Information System for Epidemiological Surveillance (SUIVE) from 2000 to 2013; to assess the discharge data of varicella and HZ, we evaluated information from the National System of health information (Sinais)...
November 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29451613/filling-process-of-the-child-health-record-in-health-care-services-of-belo-horizonte-minas-gerais-brazil
#16
Leonardo de Paula Amorim, Maria Inês Barreiros Senna, Viviane Elisângela Gomes, João Henrique Lara do Amaral, Mara Vasconcelos, Adriana Gonçalves da Silva, Simone Dutra Lucas, Raquel Conceição Ferreira
OBJECTIVE: to describe the filling process of the Child Health Record (CHR) in health care services. METHODS: descriptive study held in Belo Horizonte, Minas Gerais, Brazil; an interview was conducted with parents/guardians of children aged 3-5 years old; 21 essential items to child monitoring were observed in the CHR during the 2014 Multi-vaccination Day; fields that should be filled in maternity wards, Primary Health Care (PHC), and other services were assessed separately...
2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29451465/the-pap-test-20th-century-success-story-21st-century-has-been
#17
Jan Greene
This old standby's ultimate demise will likely take place when cervical cancer incidence declines as the HPV vaccine starts to take effect at a population level. New guidelines are being written, but insurers could have a major influence on how closely those guidelines are followed. So far, though, they haven't waded very far into the Pap-HPV debate.
February 2018: Managed Care
https://www.readbyqxmd.com/read/29451040/pulmonary-delivery-of-influenza-vaccine-formulations-in-cotton-rats-site-of-deposition-plays-a-minor-role-in-the-protective-efficacy-against-clinical-isolate-of-h1n1pdm-virus
#18
Yoshita Bhide, Jasmine Tomar, Wei Dong, Jacqueline de Vries-Idema, Henderik W Frijlink, Anke Huckriede, Wouter L J Hinrichs
Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and protective efficacy. In vivo deposition studies in cotton rats revealed that, the powder formulation was mainly deposited in the trachea ( ∼ 65%) whereas the liquid was homogenously distributed throughout the lungs ( ∼ 96%)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29451010/assessment-of-mycoplasma-gallisepticum-vaccine-efficacy-in-a-co-infection-challenge-model-with-qx-like-infectious-bronchitis-virus
#19
Dauda G Bwala, Solomon Ponman, Neil Duncan, Daniel B R Wandrag, Celia Abolnik
Mycoplasma gallisepticum (MG) is the primary cause of chronic respiratory disease in poultry. We investigated the protective efficacy of the live attenuated ts-11 and 6/85 MG vaccines against a local MG strain, and in order to enhance symptoms and mimic a typical field situation, we co-infected birds with a virulent strain of QX-like infectious bronchitis virus (IBV). Both vaccines showed similar ability to protect infected chickens from clinical signs, although ts-11 performed slightly better. Despite the lower protection against clinical disease, 6/85-vaccinated birds had significantly (P≤0...
February 16, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29450989/implementation-of-hepatitis-b-birth-dose-vaccination-%C3%A2-worldwide-2016
#20
(no author information available yet)
No abstract text is available yet for this article.
February 16, 2018: Relevé épidémiologique Hebdomadaire
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