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https://www.readbyqxmd.com/read/28649313/the-eu-aims-longitudinal-european-autism-project-leap-clinical-characterisation
#1
Tony Charman, Eva Loth, Julian Tillmann, Daisy Crawley, Caroline Wooldridge, David Goyard, Jumana Ahmad, Bonnie Auyeung, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Bhismadev Chakrabarti, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary J Holt, Johan Isaksson, Mark H Johnson, Emily J H Jones, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Luke Mason, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Barbara Ruggeri, Amber N V Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San Jóse Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve C R Williams, Marcel P Zwiers, Will Spooren, Declan G M Murphy, Jan K Buitelaar
BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28649058/buspirone-attenuates-methylphenidate-induced-growth-inhibition
#2
Nausheen Alam, Rahila Najam
Methylphenidate is effective in the treatment of attention deficit hyperactivity disorder (ADHD) in children and adults, but its long term use can cause potential adverse effect on growth rate and variable effects on appetite. Previous studies have shown that long term administration of psychostimulant drugs increases the effectiveness of somatodendritic 5-hydroxytryptamine (5-HT)-1A receptors. Repeated administration of buspirone attenuates the effectiveness of somatodendritic 5-HT1A receptors. The present study was designed to test the hypothesis that co-administration of buspirone may attenuate methylphenidate-induced effects on growth rate and food intake...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28647013/autism-spectrum-symptoms-in-a-tourette-s-disorder-sample
#3
Sabrina M Darrow, Marco Grados, Paul Sandor, Matthew E Hirschtritt, Cornelia Illmann, Lisa Osiecki, Yves Dion, Robert King, David Pauls, Cathy L Budman, Danielle C Cath, Erica Greenberg, Gholson J Lyon, William M McMahon, Paul C Lee, Kevin L Delucchi, Jeremiah M Scharf, Carol A Mathews
OBJECTIVE: Tourette's disorder (TD) and autism spectrum disorder (ASD) share clinical features and possibly an overlapping etiology. The aims of this study were to examine ASD symptom rates in participants with TD, and to characterize the relationships between ASD symptom patterns and TD, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). METHOD: Participants with TD (n = 535) and their family members (n =234) recruited for genetic studies reported TD, OCD, and ADHD symptoms and completed the Social Responsiveness Scale Second Edition (SRS), which was used to characterize ASD symptoms...
July 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28646732/effects-of-stimulants-and-atomoxetine-on-emotional-lability-in-adults-a-systematic-review-and-meta-analysis
#4
T R Moukhtarian, R E Cooper, E Vassos, P Moran, P Asherson
BACKGROUND: Emotional lability (EL) is an associated feature of attention-deficit/hyperactivity disorder (ADHD) in adults, contributing to functional impairment. Yet the effect of pharmacological treatments for ADHD on EL symptoms is unknown. We conducted a systematic review and meta-analysis to examine the effects of stimulants and atomoxetine on symptoms of EL and compare these with the effects on core ADHD symptoms. METHODS: A systematic search was conducted on the databases Embase, PsychInfo, and Ovid Medline(®) and the clinicaltrials...
May 25, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28645126/-adhd-in-adults-and-comorbid-substance-use-disorder-prevalence-clinical-diagnostics-and-integrated-therapy
#5
Henrike Dirks, Norbert Scherbaum, Bernhard Kis, Christian Mette
Substance use disorders (SUD) are one of the most frequent mental disorders among adults. Attention-Deficit/Hyperactivity-Disorder (ADHD) is one of the most common mental health issues in childhood and adolescence, often persisting in adulthood. ADHD in childhood and adolescence is a robust predictor of tobacco, alcohol and illicit substance use in adulthood. Prevalence of comorbid ADHD in SUD patients is high. Nearly one quarter of these patients fulfill the DSM IV criteria for ADHD. Integrated concepts for treatment of SUD and ADHD are needed, but rare up to now...
June 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28641216/psychoeducational-groups-for-adults-with-adhd-and-their-significant-others-pegasus-a-pragmatic-multicenter-and-randomized-controlled-trial
#6
T Hirvikoski, T Lindström, J Carlsson, E Waaler, J Jokinen, S Bölte
OBJECTIVE: To examine the feasibility, efficacy, and effectiveness of PEGASUS, a group-based structured psychoeducation for adults with ADHD and their significant others. METHOD: A pragmatic parallel group add-on design multicenter randomized controlled trial was conducted, comparing an 8-session treatment with PEGASUS (allocated n=97; 48 with ADHD and 49 with significant others) to treatment as usual (TAU, allocated n=82; 39 with ADHD and 43 significant others)...
May 9, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28640990/opiate-antagonists-do-not-interfere-with-the-clinical-benefits-of-stimulants-in-adhd-a-double-blind-placebo-controlled-trial-of-the-mixed-opioid-receptor-antagonist-naltrexone
#7
Thomas J Spencer, Pradeep Bhide, Jinmin Zhu, Stephen V Faraone, Maura Fitzgerald, Amy M Yule, Mai Uchida, Andrea E Spencer, Anna M Hall, Ariana J Koster, Joseph Biederman
OBJECTIVE: Methylphenidate activates μ-opioid receptors, which are linked to euphoria. μ-Opioid antagonists, such as naltrexone, may attenuate the euphoric effects of stimulants, thereby minimizing their abuse potential. This study assessed whether the combination of naltrexone with methylphenidate is well-tolerated while preserving the clinical benefits of stimulants in subjects with attention-deficit/hyperactivity disorder (ADHD). METHODS: We conducted a 6-week, double-blind, placebo-controlled, randomized clinical trial of naltrexone in adults with DSM-IV ADHD receiving open treatment with a long-acting formulation of methylphenidate from January 2013 to July 2015...
June 20, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28638024/-diagnosis-and-treatment-of-cognitive-impairment-in-adults-with-attention-deficit-hyperactivity-disorder
#8
L S Chutko, S Yu Surushkina, E A Yakovenko, Yu D Kropotov, A V Sergeev
AIM: To qualify cognitive impairment in adults with attention deficit hyperactivity disorder (ADHD) and evaluate the efficacy of memoplant in the treatment of this pathology. MATERIAL AND METHODS: The authors present the results of the clinical, psychological and electroencephalographic examination of 40 patients with ADHD, aged from 18 to 45 years. All patients received memoplant in dose of 240 mg a day for 8 weeks. RESULTS AND CONCLUSION: Adult patients with ADHD were characterized by both subjective and objective disorders of memory and attention...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28635543/anxiety-modulates-the-relation-between-attention-deficit-hyperactivity-disorder-severity-and-working-memory-related-brain-activity
#9
Dennis van der Meer, Pieter J Hoekstra, Daan van Rooij, Anderson M Winkler, Hanneke van Ewijk, Dirk J Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Barbara Franke, Jan K Buitelaar, Catharina A Hartman
OBJECTIVES: Individuals with attention-deficit/hyperactivity disorder (ADHD) often have heightened levels of anxiety, which has been associated with worse performance on working memory tasks. Knowledge of the neural pathways underlying the combined presence of ADHD and anxiety may aid in a better understanding of their co-occurrence. Therefore, we investigated how anxiety modulates the effect of ADHD severity on neural activity during a visuospatial working memory (VSWM) task. METHODS: Neuroimaging data were available for 371 adolescents and young adults participating in the multicentre cohort study NeuroIMAGE (average age 17...
March 1, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28629260/risk-of-dementia-in-adults-with-adhd-a-nationwide-population-based-cohort-study-in-taiwan
#10
Nian-Sheng Tzeng, Chi-Hsiang Chung, Fu-Huang Lin, Chin-Bin Yeh, San-Yuan Huang, Ru-Band Lu, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Ching Chou, Chang-Huei Tsao, Yung-Fu Wu, Wu-Chien Chien
OBJECTIVE: This study aimed to investigate the association between adults with ADHD and the risk of developing dementia. METHOD: Utilizing National Health Insurance Research Database of Taiwan, ADHD patients were identified and compared with age- and gender-matched controls (1:3). RESULTS: Of the study participants, 37 (5.48%) developed dementia compared with 81 (4.0%) in the control group. Cox proportional hazards regression analysis revealed that the study participants were more likely to develop dementia...
June 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28624582/further-replication-of-the-synergistic-interaction-between-lphn3-and-the-ntad-gene-cluster-on-adhd-and-its-clinical-course-throughout-adulthood
#11
Djenifer B Kappel, Jaqueline B Schuch, Diego L Rovaris, Bruna S da Silva, Renata B Cupertino, Cristina Winkler, Stefania P Teche, Eduardo S Vitola, Rafael G Karam, Luis A Rohde, Claiton H D Bau, Eugenio H Grevet, Nina R Mota
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common and highly heritable neuropsychiatric disorder. Despite the high heritability, the unraveling of specific genetic factors related to ADHD is hampered by its considerable genetic complexity. Recent evidence suggests that gene-gene interactions can explain part of this complexity. We examined the impact of strongly supported interaction effects between the LPHN3 gene and the NTAD gene cluster (NCAM1-TTC12-ANKK1-DRD2) in a 7-year follow-up of a clinical sample of adults with ADHD, addressing associations with susceptibility, symptomatology and stability of diagnosis...
June 15, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28622159/weeding-out-the-justification-for-marijuana-treatment-in-patients-with-developmental-and-behavioral-conditions
#12
Theodora Nelson, Yi Hui Liu, Kara S Bagot, Martin T Stein
Alex is a 13-year-old adolescent with high-functioning autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD)-combined type, anxiety, and depression. He has been resistant to engaging in therapy and treatment with various medications has been unsuccessful. Alex's parents are concerned about his anxiety, isolation, oppositional behaviors, academic underachievement, truancy, and substance use. A recent altercation with his stepfather led to a police intervention and a brief removal of Alex from the home...
June 15, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28617075/follow-up-of-young-adults-with-adhd-in-the-mta-design-and-methods-for-qualitative-interviews
#13
Thomas S Weisner, Desiree W Murray, Peter S Jensen, John T Mitchell, James M Swanson, Stephen P Hinshaw, Karen Wells, Lily Hechtman, Brooke S G Molina, L Eugene Arnold, Page Sorensen, Annamarie Stehli
OBJECTIVE: Qualitative interviews with 183 young adults (YA) in the follow-up of the Multimodal Treatment Study of Children With and Without ADHD (MTA) provide rich information on beliefs and expectations regarding ADHD, life's turning points, medication use, and substance use (SU). METHOD: Participants from four MTA sites were sampled to include those with persistent and atypically high SU, and a local normative comparison group (LNCG). Respondents were encouraged to "tell their story" about their lives, using a semistructured conversational interview format...
June 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28616934/temporal-trends-in-the-prevalence-and-incidence-of-diagnosed-adhd-in-children-and-young-adults-between-1999-and-2012-in-canada-a-data-linkage-study
#14
Helen-Maria Vasiliadis, Fatoumata Binta Diallo, Louis Rochette, Mark Smith, Donald Langille, Elizabeth Lin, Steve Kisely, Eric Fombonne, Angus H Thompson, Johanne Renaud, Alain Lesage
OBJECTIVE: There is a need for the routine monitoring of treated attention-deficit hyperactivity disorder (ADHD) for timely policy making. The objective is to report and assess over a decade the prevalence and incidence of diagnosed ADHD in Canada. METHODS: Administrative linked patient data from the provinces of Manitoba, Ontario, Quebec, and Nova Scotia were obtained from the same sources as the Canadian Chronic Diseases Surveillance Systems to assess the prevalence and incidence of a primary physician diagnosis of ADHD ( ICD-9 and ICD-10 codes: 314, F90...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28616632/dispensing-of-psychotropic-medication-among-400-000-immigrants-in-the-netherlands
#15
Fabian Termorshuizen, Jean-Paul Selten, Eibert R Heerdink
PURPOSE: Previously, a high prevalence of certain psychiatric disorders was shown among non-Western immigrants. This study explores whether this results in more prescriptions for psychotropic medication. METHODS: Data on dispensing of medication among adults living in the four largest Dutch cities in 2013 were linked to demographic data from Statistics Netherlands. Incident (i.e., following no dispensing in 2010-2012) and prevalent dispensing among immigrants was compared to that among native Dutch (N = 1,043,732) and analyzed using multivariable Poisson and logistic regression...
June 14, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28609313/attention-deficit-hyperactivity-disorder-symptoms-and-life-satisfaction-in-a-representative-adolescent-and-adult-sample
#16
Timo Hennig, Ute Koglin, Sören Schmidt, Franz Petermann, Elmar Brähler
Although it is well documented that attention-deficit/hyperactivity disorder (ADHD) is associated with reduced life satisfaction, the mechanisms that might explain this co-occurrence are unclear. We examined the correlation of ADHD symptoms with life satisfaction and whether this association is mediated by (lacking) social support and depressive symptoms. Self-reported ADHD symptoms, life satisfaction, social support, and depressive symptoms were assessed in a representative, predominantly adult sample from the general population (14-91 years, N = 2517)...
June 12, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28604931/motor-vehicle-crash-risk-among-adolescents-and-young-adults-with-attention-deficit-hyperactivity-disorder
#17
Allison E Curry, Kristina B Metzger, Melissa R Pfeiffer, Michael R Elliott, Flaura K Winston, Thomas J Power
Importance: Attention-deficit/hyperactivity disorder (ADHD) often persists into adolescence, when motor vehicle crash risk peaks. We know little about when adolescents with ADHD get licensed and, once they do, the extent to which they have increased crash risk compared with adolescents without ADHD. Objectives: To examine the association between ADHD and both driver licensing and crash involvement and whether it varies by sex, licensing age, and/or being prescribed ADHD medication at licensure...
June 12, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28601956/subjective-distress-associated-with-adult-adhd-evaluation-of-a-new-self-report
#18
Rosetta Nicastro, Martin Desseilles, Paco Prada, Sébastien Weibel, Nader Perroud, Marianne Gex-Fabry
The current study aims at documenting the psychometric properties of the Subjective Distress Associated with Adult ADHD-Self-Report (SDAAA-SR), a newly developed instrument for the assessment of psychological suffering in ADHD adults. The SDAAA-SR was administered to 247 students and 142 ADHD adults. Factor structure, internal consistency, test-retest reliability, convergent validity and discriminant validity were assessed. Sensitivity to change was examined in a subsample of 25 ADHD patients who participated in a 1-year therapy...
June 10, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28601690/parental-adhd-symptoms-and-parenting-behaviors-a-meta-analytic-review
#19
REVIEW
Joanne L Park, Kristen L Hudec, Charlotte Johnston
Attention-deficit/hyperactivity disorder (ADHD) persists throughout the lifespan, and there are known impairments associated with adult ADHD. Understanding ADHD-related impairments in the parenting domain is particularly important given that the children of adults with ADHD also are likely to have ADHD, and there is potential for parenting to alter the developmental outcomes of these children. The present study quantitatively synthesizes evidence regarding the associations between parental ADHD symptoms and parenting behaviors...
May 29, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28594055/influence-of-attention-deficit-hyperactivity-disorder-symptoms-on-quality-of-life-and-functionality-in-adults-with-eating-disorders
#20
Francisco Ferre, Julia Cambra, Mercedes Ovejero, Ignacio Basurte-Villamor
INTRODUCTION: Eating disorders (ED) have been linked to attention deficit hyperactivity disorder (ADHD) because they present some symptoms in common. The aim of this study was to explore the influence on ED of symptoms suggestive of adult ADHD and how these symptoms affect the clinical presentation of adult patients. A further aim was to assess the impact of ADHD symptoms on quality of life and feelings of disability. METHOD: Participants comprised 89 patients diagnosed with ED according to DSM-5 criteria...
May 2017: Actas Españolas de Psiquiatría
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