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https://www.readbyqxmd.com/read/28549145/six-month-safety-data-of-recombinant-vesicular-stomatitis-virus-zaire-ebola-virus-envelope-glycoprotein-vaccine-in-a-phase-3-double-blind-placebo-controlled-randomized-study-in-healthy-adults
#1
Scott A Halperin, Jose R Arribas, Richard Rupp, Charles P Andrews, Laurence Chu, Rituparna Das, Jakub K Simon, Matthew T Onorato, Kenneth Liu, Jason Martin, Frans A Helmond
Background.: This study (NCT02503202) evaluated the safety of recombinant vesicular stomatitis virus-Zaire Ebola virus envelope glycoprotein vaccine (rVSVΔG-ZEBOV-GP). Methods.: Overall, 1197 subjects were randomized 2:2:2:2:1; 1194 were vaccinated with 1 dose of 1 of 3 lots of rVSVΔG- ZEBOV-GP (2 × 107 plaque-forming units [pfu], n = 797; combined-lots group), a single high-dose lot of rVSVΔG-ZEBOV-GP (1 × 108 pfu, n = 264; high-dose group), or placebo (n = 133)...
May 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28549079/computational-modeling-of-immune-system-of-the-fish-for-a-more-effective-vaccination-in-aquaculture
#2
Alice Madonia, Cristiano Melchiorri, Simone Bonamano, Marco Marcelli, Chiara Bulfon, Filippo Castiglione, Marco Galeotti, Donatella Volpatti, Francesco Mosca, Pietro-Giorgio Tiscar, Nicla Romano
Motivation: A computational model equipped with the main immunological features of the sea bass ( Dicentrarchus labrax L. ) immune system was used to predict more effective vaccination in fish. The performance of the model was evaluated by using the results of two in vivo vaccinations trials against L. anguillarum and P. damselae . Tests were performed to select the appropriate doses of vaccine and infectious bacteria to set up the model. Simulation outputs were compared with the specific antibody production and the expression of BcR and TcR gene transcripts in spleen...
May 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28548690/rainbow-trout-oncorhynchus-mykiss-immune-response-towards-a-recombinant-vaccine-targeting-the-parasitic-ciliate-ichthyophthirius-multifiliis
#3
L von Gersdorff Jørgensen, P W Kania, K J Rasmussen, A H Mattsson, J Schmidt, A Al-Jubury, A Sander, A Salanti, K Buchmann
The protective effect in rainbow trout (Oncorhynchus mykiss) of an experimental subunit vaccine targeting antigens in the parasite Ichthyophthirius multifiliis has been evaluated and compared to effects elicited by a classical parasite homogenate vaccine. Three recombinant parasite proteins (two produced in E. coli and one in insect cells) were combined and injected i.p., and subsequently, protection and antibody responses were analysed. Both the experimental and the benchmark vaccine induced partial but significant protection against I...
May 26, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28548689/phenotype-of-aeromonas-salmonicida-sp-salmonicida-cyclic-adenosine-3-5-monophosphate-receptor-protein-crp-mutants-and-its-virulence-in-rainbow-trout-oncorhynchus-mykiss
#4
K Valderrama, M Saravia, J Santander
Precise deletion of genes related to virulence can be used as a strategy to produce attenuated bacterial vaccines. Here, we study the deletion of the cyclic-3',5'-adenosine monophosphate (cAMP) receptor protein (Crp) in Aeromonas salmonicida, the aetiologic agent of furunculosis in marine and freshwater fish. The Crp protein is a conserved global regulator, controlling physiology processes, like sugar utilization. Deletion of the crp gene has been utilized in live attenuated vaccines for mammals, birds and warm water fish...
May 26, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28548686/studies-on-the-antibody-response-and-side-effects-after-intramuscular-and-intraperitoneal-injection-of-atlantic-lumpfish-cyclopterus-lumpus-l-with-different-oil-based-vaccines
#5
T Erkinharju, M R Lundberg, E Isdal, I Hordvik, R A Dalmo, T Seternes
Atlantic lumpfish (Cyclopterus lumpus L.) is used as a biological delousing agent for sea lice (Lepeophtheirus salmonis K.) infestations in Norwegian aquaculture. Here, we present a study on the antibody response and vaccine side effects after intramuscular and intraperitoneal injection of lumpfish with two vaccines. Both vaccines contained bacterial antigens from atypical Aeromonas salmonicida A-layer types V and VI, Vibrio anguillarum serotype O1 and Moritella viscosa sp., but one vaccine contained a vegetable oil-based adjuvant, while the other contained a mineral oil-based adjuvant...
May 26, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28548638/asymmetric-recognition-of-hiv-1-envelope-trimer-by-v1v2-loop-targeting-antibodies
#6
Haoqing Wang, Harry B Gristick, Louise Scharf, Anthony P West, Rachel P Galimidi, Michael S Seaman, Natalia T Freund, Michel C Nussenzweig, Pamela J Bjorkman
The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab to the apex of the symmetric Env trimer using a protruding CDRH3 to penetrate the Env glycan shield. Here we characterized a distinct mode of V1V2 epitope recognition by the new bNAb BG1 in which two Fabs bind asymmetrically per Env trimer using a compact CDRH3...
May 26, 2017: ELife
https://www.readbyqxmd.com/read/28548626/correlates-of-protection-for-inactivated-enterovirus-71-vaccine-the-analysis-of-immunological-surrogate-endpoints
#7
Wenbo Zhu, Pengfei Jin, Jing-Xin Li, Feng-Cai Zhu, Pei Liu
BACKGROUND: Inactivated Enterovirus 71 (EV71) vaccines showed significant efficacy against the diseases associated with EV71 and a neutralizing antibody (NTAb) titer of 1:16-1:32 was suggested as the correlates of the vaccine protection. This paper aims to further estimate the immunological surrogate endpoints for the protection of inactivated EV71 vaccines and the effect factors. METHOD: Pre-vaccination NTAb against EV71 at baseline (day 0), post-vaccination NTAb against EV71 at day 56, and the occurrence of laboratory-confirmed EV71-associated diseases during a 24-months follow-up period were collected from a phase 3 efficacy trial of an inactivated EV71 vaccine...
May 26, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28548547/facing-a-health-threat-in-a-complex-information-environment-a-national-representative-survey-examining-american-adults-behavioral-responses-to-the-2009-2010-a-h1n1-pandemic
#8
Leesa Lin, Rachel F McCloud, Minsoo Jung, Kasisomayajula Viswanath
BACKGROUND: Recent A(H1N1) studies suggest that intrapersonal and interpersonal factors may exert influence on people's preventive behaviors for avoiding the flu during pandemics. AIMS: Nonpharmaceutical interventions (NPIs) and vaccinations play key roles in containing disease transmission during a pandemic. We examined how intrapersonal and interpersonal factors influenced adoption of NPIs and vaccine uptake during the A(H1N1) pandemic of 2009. METHOD: The data come from a nationally representative sample survey of 1,569 American adults...
May 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28548546/the-risk-of-herpes-zoster-in-patients-with-ankylosing-spondylitis-analysis-of-the-korean-national-health-insurance-service-sample-cohort-database
#9
Doo-Ho Lim, Ye-Jee Kim, Seon Ok Kim, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
OBJECTIVES: The aims of our study were to determine whether the use of conventional disease-modifying antirheumatic drugs (cDMARDs) or tumor necrosis factor α (TNFα) inhibitors increase the risk of herpes zoster (HZ) in patients with ankylosing spondylitis (AS). METHODS: We searched the South Korean National Health Insurance Service - National Sample Cohort Database for relevant patient records between 2002 and 2013. We evaluated the incidence of HZ by categorizing patients into in three treatment groups: disease-modifying antirheumatic drug (DMARD) nonusers, cDMARD users and TNFα inhibitor users...
May 26, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28548489/glycosaminoglycans-specific-cell-targeting-and-imaging-using-fluorescent-nanodiamonds-coated-with-viral-envelope-proteins
#10
Minh D Pham, Chandra Prakash Epperla, Chia-Lung Hsieh, Wen Chang, Huan-Cheng Chang
Understanding virus-host interactions is crucial for vaccine development. This study investigates such interactions using fluorescent nanodiamonds (FNDs) coated with vaccinia envelope proteins as the model system. To achieve this goal, we noncovalently conjugated 100-nm FND with A27(aa 21-84), a recombinant envelope protein of vaccinia virus, for glycosaminoglycans (GAGs)-specific targeting and imaging of living cells. Another recombinant protein A27(aa 33-84) that removes the GAGs-binding sequences was also used for comparison...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28548348/ecological-mental-health-promotion-the-case-of-suicide-prevention-21st-century-mental-health-analogues-for-clean-water-improved-sanitation-and-vaccines
#11
EDITORIAL
John R Cutcliffe
No abstract text is available yet for this article.
June 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28548079/design-of-live-attenuated-bacterial-vaccines-based-on-d-glutamate-auxotrophy
#12
Maria P Cabral, Patricia García, Alejandro Beceiro, Carlos Rumbo, Astrid Pérez, Miriam Moscoso, Germán Bou
Vaccine development is a priority for global health due to the growing multidrug resistance in bacteria. D-glutamate synthesis is essential for bacterial cell wall formation. Here we present a strategy for generating effective bacterial whole-cell vaccines auxotrophic for D-glutamate. We apply this strategy to generate D-glutamate auxotrophic vaccines for three major pathogens, Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus. These bacterial vaccines show virulence attenuation and self-limited growth in mice, and elicit functional and cross-reactive antibodies, and cellular immunity...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28547947/virologic-monitoring-of-poliovirus-type-2-after-opv2-withdrawal-in-april-2016-an-important-advance-in-eradicating-poliomyelitis-and-eliminating-live-oral-poliovirus-vaccines-worldwide-2016%C3%A2-2017
#13
(no author information available yet)
No abstract text is available yet for this article.
May 26, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/28546954/pleiotropic-cytotoxicity-of-vaca-toxin-in-host-cells-and-its-impact-on-immunotherapy
#14
REVIEW
Farnaz Fahimi, Mohammad Reza Tohidkia, Mehdi Fouladi, Reza Aghabeygi, Naser Samadi, Yadollah Omidi
Introduction: In the recent decades, a number of studies have highlighted the importance of Helicobacter pylori in the initiation and development of peptic ulcer and gastric cancer. Some potential virulence factors (e.g., urease, CagA, VacA, BabA) are exploited by this microorganism, facilitating its persistence through evading human defense mechanisms. Among these toxins and enzymes, vacuolating toxin A (VacA) is of a great importance in the pathogenesis of H. pylori. VacA toxin shows different pattern of cytotoxicity through binding to different cell surface receptors in various cells...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546878/effects-of-medicare-coverage-of-a-welcome-to-medicare-visit-on-use-of-preventive-services-among-new-medicare-enrollees
#15
Boon Peng Ng, Gail A Jensen, Heather Fritz
In January 2005, Medicare began covering a one-time initial preventive physical examination (IPPE), also called a "Welcome-to-Medicare" visit, during a beneficiary's first 6 months under Part B. This paper examines the effects of offering Medicare IPPE coverage on the use of mammograms, breast self-exams, Pap smears, prostate cancer screenings, cholesterol screenings, and flu vaccines among beneficiaries new to Part B. We adopt a difference-in-difference estimator and estimate a set of multivariate logit models to quantify the effects of introducing Medicare IPPE coverage on the use of preventive services...
2017: Journal of Aging Research
https://www.readbyqxmd.com/read/28546868/evaluation-of-porcine-reproductive-and-respiratory-syndrome-stabilization-protocols-in-23-french-farrow-to-finish-farms-located-in-a-high-density-swine-area
#16
Pauline Berton, Valérie Normand, Guy-Pierre Martineau, Franck Bouchet, Arnaud Lebret, Agnès Waret-Szkuta
BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) is responsible for reproductive disorders in sows and respiratory problems in pigs, and has a major economic impact. Controlling PRRSV is therefore a priority for the swine industry. Stabilization of a herd, defined as the production of PRRSV-negative pigs at weaning from seropositive sows, is a common method of control, and different protocols have been described in the literature to achieve this stabilization. CONTEXT AND PURPOSE: The objective of this study was to evaluate wether the combination of mass vaccination of sows and their piglets with a Genotype I modified live virus (MLV) vaccine, with temporal closure to the introduction of replacement animals and unidirectional pig and human flow can result in the production of PRRSV-negative pigs at weaning...
2017: Porcine Health Management
https://www.readbyqxmd.com/read/28546785/on-religious-and-secular-exemptions-a-case-study-of-childhood-vaccination-waivers
#17
Roland Pierik
This paper analyses exemptions to general law through the prism of vaccine waivers in the United States. All US states legally require the vaccination of children prior to school or daycare entry; however, this obligation is accompanied with a system of medical, religious, and/or philosophical exemptions. Nonmedical exemptions became subject of discussion after the 2015 Disneyland measles outbreak in California, which unequivocally brought to light what had been brewing below the surface for a while: a slow but steady decline in vaccination rates in Western societies, resulting in the reoccurrence of measles outbreaks...
April 2017: Ethnicities
https://www.readbyqxmd.com/read/28546518/safety-immunogenicity-and-cross-species-protection-of-a-plasmid-dna-encoding-plasmodium-falciparum-sera5-polypeptide-microbial-epitopes-and-chemokine-genes-in-mice-and-olive-baboons
#18
Nyamongo Onkoba, Ruth M Mumo, Horace Ochanda, Charles Omwandho, Hastings S Ozwara, Thomas G Egwang
Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of strain-transcending malarial vaccines. The present study sought to determine safety, immunogenicity and cross-species efficacy ofPlasmodium falciparum serine repeat antigen 5 polypeptide co-expressed with epitopes of Bacille-Calmette Guerin (BCG), tetanus toxoid (TT) and a chemokine gene. Olive baboons and BALB/c mice were randomly assigned into vaccine and control groups. The vaccine group animals were primed and boosted twice with pIRES plasmids encoding the SERA5+ BCG+ TT alone, or with either CCL5 or CCL20 and the control group with pIRES plasmid vector backbone...
April 6, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28546406/yonder-adolescence-vaccination-leadership-and-fashion-models
#19
Ahmed Rashid
No abstract text is available yet for this article.
June 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28546072/dendrimer-conjugated-peptide-vaccine-enhances-clearance-of-chlamydia-trachomatis-genital-infection
#20
Ingrid S Ganda, Qian Zhong, Mirabela Hali, Ricardo L C Albuquerque, Francine F Padilha, Sandro R P da Rocha, Judith A Whittum-Hudson
Peptide-based vaccines have emerged in recent years as promising candidates in the prevention of infectious diseases. However, there are many challenges to maintaining in vivo peptide stability and enhancement of peptide immunogenicity to generate protective immunity which enhances clearance of infections. Here, a dendrimer-based carrier system is proposed for peptide-based vaccine delivery, and shows its anti-microbial feasibility in a mouse model of Chlamydia trachomatis. Chlamydiae are the most prevalent sexually transmitted bacteria worldwide, and also the causal agent of trachoma, the leading cause of preventable infectious blindness...
May 22, 2017: International Journal of Pharmaceutics
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