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https://www.readbyqxmd.com/read/28430144/a-systems-biology-approach-using-transcriptomic-data-reveals-genes-and-pathways-in-porcine-skeletal-muscle-affected-by-dietary-lysine
#1
Taiji Wang, Jean M Feugang, Mark A Crenshaw, Naresh Regmi, John R Blanton, Shengfa F Liao
Nine crossbred finishing barrows (body weight 94.4 ± 6.7 kg) randomly assigned to three dietary treatments were used to investigate the effects of dietary lysine on muscle growth related metabolic and signaling pathways. Muscle samples were collected from the longissimus dorsi of individual pigs after feeding the lysine-deficient (4.30 g/kg), lysine-adequate (7.10 g/kg), or lysine-excess (9.80 g/kg) diet for five weeks, and the total RNA was extracted afterwards. Affymetrix Porcine Gene 1.0 ST Array was used to quantify the expression levels of 19,211 genes...
April 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28424884/principle-and-basic-property-of-the-sequential-flow-pump
#2
Shintaro Hara, Erina Maeno, Xinyang Li, Terumi Yurimoto, Takashi Isoyama, Itsuro Saito, Toshiya Ono, Yusuke Abe
In the emergency care field, early treatment of acute heart or respiratory failure has been a global concern. In severe cases, patients are frequently required to be on an extracorporeal membrane oxygenator (ECMO) life support. To make the ECMO system more compact and portable, we proposed a sequential flow-type centrifugal pump named the sequential flow pump (SFP). In this study, principle and basic properties of this novel blood pump were examined by computational fluid dynamic (CFD) analysis and an experimental model...
April 19, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28422684/visual-analysis-of-inclusion-dynamics-in-two-phase-flow
#3
Grzegorz Karch, Fabian Beck, Moritz Ertl, Christian Meister, Kathrin Schulte, Bernhard Weigand, Thomas Ertl, Filip Sadlo
In single-phase flow visualization, research focuses on the analysis of vector field properties. In two-phase flow, in contrast, analysis of the phase components is typically of major interest. So far, visualization research of two-phase flow concentrated on proper interface reconstruction and the analysis thereof. In this paper, we present a novel visualization technique that enables the investigation of complex two-phase flow phenomena with respect to the physics of breakup and coalescence of inclusions. On the one hand, we adapt dimensionless quantities for a localized analysis of phase instability and breakup, and provide detailed inspection of breakup dynamics with emphasis on oscillation and its interplay with rotational motion...
April 12, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28416127/experimental-and-modelling-of-arthrospira-platensis-cultivation-in-open-raceway-ponds
#4
Panneerselvam Ranganathan, J C Amal, S Savithri, Ajith Haridas
In this study, the growth of Arthrospira platensis was studied in an open raceway pond. Furthermore, dynamic model for algae growth and CFD modelling of hydrodynamics in open raceway pond were developed. The dynamic behaviour of the algal system was developed by solving mass balance equations of various components, considering light intensity and gas-liquid mass transfer. A CFD modelling of the hydrodynamics of open raceway pond was developed by solving mass and momentum balance equations of the liquid medium...
March 27, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28415002/experimental-and-numerical-study-of-liquefied-natural-gas-lng-pool-spreading-and-vaporization-on-water
#5
Nirupama Gopalaswami, Konstantinos Kakosimos, Bin Zhang, Yi Liu, R Mentzer, M Sam Mannan
The investigation of pool spreading and vaporization phenomenon is an essential part of consequence analysis to determine the severity of LNG spills on water. In this study, release of LNG on water during marine operations is studied through experimental and numerical methods The study involves emulation of an LNG leak from transfer arms during side by side loading operations. The experimental part involves flow of LNG in a narrow trench filled with water and subsequent measurement of pool spreading and vaporization parameters...
April 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28414873/influence-of-pharyngeal-airway-respiration-pressure-on-class-ii-mandibular-retrusion-in-children-a-computational-fluid-dynamics-study-of-inspiration-and-expiration
#6
T Iwasaki, H Sato, H Suga, Y Takemoto, E Inada, I Saitoh, K Kakuno, R Kanomi, Y Yamasaki
OBJECTIVES: To examine the influence of negative pressure of the pharyngeal airway on mandibular retraction during inspiration in children with nasal obstruction using the computational fluid dynamics (CFD) method. SETTING AND SAMPLE POPULATION: Sixty-two children were divided into Classes I, II (mandibular retrusion) and III (mandibular protrusion) malocclusion groups. MATERIAL AND METHODS: Cone-beam computed tomography data were used to reconstruct three-dimensional shapes of the nasal and pharyngeal airways...
May 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28413231/development-of-a-roof-bolter-canopy-air-curtain-for-respirable-dust-control
#7
W R Reed, G J Joy, B Kendall, A Bailey, Y Zheng
Testing of the roof bolter canopy air curtain (CAC) designed by the U.S. National Institute for Occupational Safety and Health (NIOSH) has gone through many iterations, demonstrating successful dust control performance under controlled laboratory conditions. J.H. Fletcher & Co., an original equipment manufacturer of mining equipment, further developed the concept by incorporating it into the design of its roof bolting machines. In the present work, laboratory testing was conducted, showing dust control efficiencies ranging from 17...
January 2017: Mining Engineering
https://www.readbyqxmd.com/read/28395878/cerebral-aneurysm-blood-flow-simulations-are-sensitive-to-basic-solver-settings
#8
Kendall D Dennis, David F Kallmes, Dan Dragomir-Daescu
Computational modeling of peri-aneurysmal hemodynamics is typically carried out with commercial software without knowledge of the sensitivity of the model to variation in input values. For three aneurysm models, we carried out a formal sensitivity analysis and optimization strategy focused on variation in timestep duration and model residual error values and their impact on hemodynamic outputs. We examined the solution sensitivity to timestep sizes of 10(-3)s, 10(-4)s, and 10(-5)s while using model residual error values of 10(-4), 10(-5), and 10(-6) using ANSYS Fluent to observe compounding errors and to optimize solver settings for computational efficiency while preserving solution accuracy...
April 3, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28387372/computational-fluid-dynamics-simulation-of-the-upper-airway-response-to-large-incisor-retraction-in-adult-class-i-bimaxillary-protrusion-patients
#9
Zhe Zheng, Hong Liu, Qi Xu, Wei Wu, Liling Du, Hong Chen, Yiwen Zhang, Dongxu Liu
The changes of the upper airway after large retraction of the incisors in adult class I bimaxillary protrusion patients were assessed mainly focused on the anatomic variation and ignored the functional changes. This study aimed to investigate the changes of the upper airway in adult class I bimaxillary protrusion patients after extraction treatment using the functional images based on computational fluid dynamics (CFD). CFD was implemented after 3D reconstruction based on the CBCT of 30 patients who have completed extraction treatment...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28382440/tetralogy-of-fallot-surgical-repair-shunt-configurations-ductus-arteriosus-and-the-circle-of-willis
#10
Senol Piskin, Gozde Unal, Ahmet Arnaz, Tayyar Sarioglu, Kerem Pekkan
In this study, hemodynamic performance of three novel shunt configurations that are considered for the surgical repair of tetralogy of Fallot (TOF) disease are investigated in detail. Clinical experience suggests that the shunt location, connecting angle, and its diameter can influence the post-operative physiology and the neurodevelopment of the neonatal patient. An experimentally validated second order computational fluid dynamics (CFD) solver and a parametric neonatal diseased great artery model that incorporates the ductus arteriosus (DA) and the full patient-specific circle of Willis (CoW) are employed...
April 5, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28382098/cardioprotective-effect-of-dexrazoxane-in-patients-with-her2-positive-breast-cancer-who-receive-anthracycline-based-adjuvant-chemotherapy-followed-by-trastuzumab
#11
In-Ho Kim, Ji Eun Lee, Ho-Joong Youn, Byung Joo Song, Byung Joo Chae
PURPOSE: We intended to determine whether dexrazoxane (DZR) is cardioprotective during administration of adjuvant anthracycline-based chemotherapy followed by a 1-year trastuzumab treatment. METHODS: The medical records of 228 patients who underwent surgical resection and received adjuvant chemotherapy with trastuzumab for human epidermal growth factor receptor type 2 (HER2)-positive breast cancer between January 2010 and December 2014 were reviewed. Approximately 25% of patients received DZR prior to each administration of doxorubicin during doxorubicin with cyclophosphamide (AC) chemotherapy...
March 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28379938/effects-of-cone-shaped-bend-inlet-cannulas-of-an-axial-blood-pump-on-thrombus-formation-an-experiment-and-simulation-study
#12
Guangmao Liu, Jianye Zhou, Hansong Sun, Yan Zhang, Haibo Chen, Shengshou Hu
BACKGROUND Cannula shape and connection style influence the risk of thrombus formation in the blood pump by varying the blood flow characteristics inside the pump. Inlet cannulas should be designed based on the need for anatomical fit and reducing the risk of thrombus generation in the blood pump. The effects on thrombus formation of the cone-shaped bend inlet cannulas of axial blood pumps should be studied. MATERIAL AND METHODS The cannulas were designed as cone-shaped, with 1 bent section connecting 2 straight sections...
April 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28367643/computational-fluid-dynamics-in-abdominal-aorta-bifurcation-non-newtonian-versus-newtonian-blood-flow-in-a-real-case-study
#13
Armando A Soares, Sílvia Gonzaga, Carlos Oliveira, André Simões, Abel I Rouboa
Hemodynamic in abdominal aorta bifurcation was investigated in a real case using computational fluid dynamics. A Newtonian and non-Newtonian (Walburn-Schneck) viscosity models were compared. The geometrical model was obtained by 3D reconstruction from CT-scan and hemodynamic parameters obtained by laser-Doppler. Blood was assumed incompressible fluid, laminar flow in transient regime and rigid vessel wall. Finite volume-based was used to study the velocity, pressure, wall shear stress (WSS) and viscosity throughout cardiac cycle...
April 3, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28348044/model-assisted-measurements-of-suspension-feeding-flow-velocities
#14
Kevin T Du Clos, Ian T Jones, Tyler J Carrier, Damian C Brady, Peter A Jumars
Benthic marine suspension feeders provide an important link between benthic and pelagic ecosystems. The strength of this link is determined by suspension-feeding rates. Many studies have measured suspension-feeding rates using indirect clearance-rate methods, which are based on the depletion of suspended particles. Direct methods that measure the flow of water itself are less common, but they can be more broadly applied because, unlike indirect methods, direct methods are not affected by properties of the cleared particles...
March 27, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28339176/identification-of-likely-associations-between-cerebral-folate-deficiency-and-complex-genetic-and-metabolic-pathogenesis-of-autism-spectrum-disorders-by-utilization-of-a-pilot-interaction-modeling-approach
#15
Daniel Krsička, Jan Geryk, Markéta Vlčková, Markéta Havlovicová, Milan Macek, Radka Pourová
Recently, cerebral folate deficiency (CFD) was suggested to be involved in the pathogenesis of autism spectrum disorders (ASD). However, the exact role of folate metabolism in the pathogenesis of ASD, identification of underlying pathogenic mechanisms and impaired metabolic pathways remain unexplained. The aim of our study was to develop and test a novel, unbiased, bioinformatics approach in order to identify links between ASD and disturbed cerebral metabolism by focusing on abnormal folate metabolism, which could foster patient stratification and novel therapeutic interventions...
March 24, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28336097/ranking-current-and-prospective-no2-pollution-mitigation-strategies-an-environmental-and-economic-modelling-investigation-in-oxford-street-london
#16
A P R Jeanjean, J Gallagher, P S Monks, R J Leigh
Air pollution continues to be a problem in the urban environment. A range of different pollutant mitigation strategies that promote dispersion and deposition exist, but there is little evidence with respect to their comparative performance from both an environmental and economic perspective. This paper focuses on examining different NO2 mitigation strategies such as trees, buildings facades coated with photocatalytic paint and solid barriers in Oxford Street in London. The case study findings will support ranking the environmental and economic impacts of these different strategies to improve personal exposure conditions on the footpath and on the road in a real urban street canyon...
March 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28332469/marrying-step-feed-with-clarifier-improvements-increase-wet-weather-capacity-integrated-methodology
#17
Glen T Daigger John S Siczka Thomas F Smith David A Frank J A McCorquodale
The need to increase the peak wet weather secondary treatment capacity of the City of Akron, OH, Water Reclamation Facility (WRF) provided the opportunity to test an integrated methodology for maximizing the peak wet weather secondary treatment capacity of activated sludge systems. An initial investigation, consisting of process modeling of the secondary treatment system and computational fluid dynamics (CFD) analysis of the existing relatively shallow secondary clarifiers (3.3 and 3.7 m sidewater depth in 30...
March 22, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28332407/unsteady-computational-fluid-dynamics-in-front-crawl-swimming
#18
Mathias Samson, Anthony Bernard, Tony Monnet, Patrick Lacouture, Laurent David
The development of codes and power calculations currently allows the simulation of increasingly complex flows, especially in the turbulent regime. Swimming research should benefit from these technological advances to try to better understand the dynamic mechanisms involved in swimming. An unsteady Computational Fluid Dynamics (CFD) study is conducted in crawl, in order to analyse the propulsive forces generated by the hand and forearm. The k-ω SST turbulence model and an overset grid method have been used...
March 23, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28324943/overcoming-spatio-temporal-limitations-using-dynamically-scaled-in-vitro-pc-mri-a-flow-field-comparison-to-true-scale-computer-simulations-of-idealized-stented-and-patient-specific-left-main-bifurcations
#19
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322433/a-9-pool-metabolic-structured-kinetic-model-describing-days-to-seconds-dynamics-of-growth-and-product-formation-by-penicillium-chrysogenum
#20
Wenjun Tang, Amit T Deshmukh, Cees Haringa, Guan Wang, Walter van Gulik, Wouter van Winden, Matthias Reuss, Joseph J Heijnen, Jianye Xia, Ju Chu, Henk J Noorman
A powerful approach for the optimization of industrial bioprocesses is to perform detailed simulations integrating large scale computational fluid dynamics (CFD) and cellular reaction dynamics (CRD). However, complex metabolic kinetic models containing a large number of equations pose formidable challenges in CFD-CRD coupling and computation time afterward. This necessitates to formulate a relatively simple but yet representative model structure. Such a kinetic model should be able to reproduce metabolic responses for short-term (mixing time scale of tens of seconds) and long-term (fed-batch cultivation of hours/days) dynamics in industrial bioprocesses...
March 21, 2017: Biotechnology and Bioengineering
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