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https://www.readbyqxmd.com/read/28196148/from-the-track-to-the-ocean-using-flow-control-to-improve-marine-bio-logging-tags-for-cetaceans
#1
Giovani Fiore, Erik Anderson, C Spencer Garborg, Mark Murray, Mark Johnson, Michael J Moore, Laurens Howle, K Alex Shorter
Bio-logging tags are an important tool for the study of cetaceans, but superficial tags inevitably increase hydrodynamic loading. Substantial forces can be generated by tags on fast-swimming animals, potentially affecting behavior and energetics or promoting early tag removal. Streamlined forms have been used to reduce loading, but these designs can accelerate flow over the top of the tag. This non-axisymmetric flow results in large lift forces (normal to the animal) that become the dominant force component at high speeds...
2017: PloS One
https://www.readbyqxmd.com/read/28181817/mathematical-modeling-of-intraperitoneal-drug-delivery-simulation-of-drug-distribution-in-a-single-tumor-nodule
#2
Margo Steuperaert, Giuseppe Falvo D'Urso Labate, Charlotte Debbaut, Olivier De Wever, Christian Vanhove, Wim Ceelen, Patrick Segers
The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for peritoneal carcinomatosis, allowing for higher intratumor concentrations of the cytotoxic agent compared to intravenous administration. Nevertheless, drug penetration depths are still limited to a few millimeters. It is thus necessary to better understand the limiting factors behind this poor penetration in order to improve IP chemotherapy delivery. By developing a three-dimensional computational fluid dynamics (CFD) model for drug penetration in a tumor nodule, we investigated the impact of a number of key parameters on the drug transport and penetration depth during IP chemotherapy...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28167213/metagenomics-approach-to-the-study-of-the-gut-microbiome-structure-and-function-in-zebrafish-danio-rerio-fed-with-gluten-formulated-diet
#3
Hyunmin Koo, Joseph A Hakim, Mickie L Powell, Ranjit Kumar, Peter G Eipers, Casey D Morrow, Michael Crowley, Elliot J Lefkowitz, Stephen A Watts, Asim K Bej
In this study, we report the gut microbial composition and predictive functional profiles of zebrafish, Danio rerio, fed with a control formulated diet (CFD), and a gluten formulated diet (GFD) using metagenomics approach and bioinformatics tools. The microbial communities of the GFD-fed D. rerio displayed heightened abundances of Legionellales, Rhizobiaceae, and Rhodobacter, as compared to the CFD-fed counterparts. Predicted metagenomics of microbial communities (PICRUSt) in GFD-fed D. rerio showed KEGG functional categories corresponding to bile secretion, secondary bile acid biosynthesis, and the metabolism of glycine, serine, and threonine...
February 3, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28161877/minimizing-the-blood-velocity-differences-between-phase-contrast-magnetic-resonance-imaging-and-computational-fluid-dynamics-simulation-in-cerebral-arteries-and-aneurysms
#4
Mohd Azrul Hisham Mohd Adib, Satoshi Ii, Yoshiyuki Watanabe, Shigeo Wada
The integration of phase-contrast magnetic resonance images (PC-MRI) and computational fluid dynamics (CFD) is a way to obtain detailed information of patient-specific hemodynamics. This study proposes a novel strategy for imposing a pressure condition on the outlet boundary (called the outlet pressure) in CFD to minimize velocity differences between the PC-MRI measurement and the CFD simulation, and to investigate the effects of outlet pressure on the numerical solution. The investigation involved ten patient-specific aneurysms reconstructed from a digital subtraction angiography image, specifically on aneurysms located at the bifurcation region...
February 4, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28155704/the-movement-and-deposition-of-pm2-5-in-the-upper-respiratory-tract-for-the-patients-with-heart-failure-an-elementary-cfd-study
#5
Tiantian Zhang, Bin Gao, Zhixiang Zhou, Yu Chang
BACKGROUND: PM2.5 is an important factor to affect the patients with respiratory and cardiovascular diseases. Clinical studies have found that the morbidity and mortality of patients with heart failure (HF) have a close relationship with the movement and deposition state of PM2.5. One reason is that the breathing pattern of patients with HF has obvious difference with healthy people, however the effect caused by these differences on the distribution regularity of PM2.5 in the respiratory tract is still unclear...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155672/the-study-on-hemodynamic-effect-of-series-type-lvad-on-aortic-blood-flow-pattern-a-primary-numerical-study
#6
Qi Zhang, Bin Gao, Yu Chang
BACKGROUND: Left ventricular assist device (LVAD) has become an alternative treatment for end-stage heart failure patients. Series type of LVAD, as a novel LVAD, has attracted more and more attention. The hemodynamic effects of series type LVAD on aortic blood pattern are considered as its important characteristics; however, the precise mechanism of it is still unclear. METHODS: To clarify the hemodynamic effects of series type LVAD on aortic blood flow pattern, a comparative study on the aortic blood flow pattern and hemodynamic states were carried out numerically for two cases, including series type LVAD support and normal condition...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28154426/a-new-experiment-for-investigating-evaporation-and-condensation-of-cryogenic-propellants
#7
K Bellur, E F Médici, M Kulshreshtha, V Konduru, D Tyrewala, A Tamilarasan, J McQuillen, J Leao, D S Hussey, D L Jacobson, J Scherschligt, J C Hermanson, C K Choi, J S Allen
Passive and active technologies have been used to control propellant boil-off, but the current state of understanding of cryogenic evaporation and condensation in microgravity is insufficient for designing large cryogenic depots critical to the long-term space exploration missions. One of the key factors limiting the ability to design such systems is the uncertainty in the accommodation coefficients (evaporation and condensation), which are inputs for kinetic modeling of phase change. A novel, combined experimental and computational approach is being used to determine the accommodation coefficients for liquid hydrogen and liquid methane...
March 2016: Cryogenics
https://www.readbyqxmd.com/read/28152457/numerical-investigations-of-flow-and-passive-pollutant-exposure-in-high-rise-deep-street-canyons-with-various-street-aspect-ratios-and-viaduct-settings
#8
Lejian He, Jian Hang, Xuemei Wang, Borong Lin, Xiaohui Li, Guangdong Lan
Vehicular pollutant exposure of residents and pedestrians in high-rise deep street canyons with viaducts and noise barriers requires special concerns because the ventilation capacity is weak and the literature reported inconsistent findings on flow patterns as aspect ratios (building height/street width, H/W) are larger than 2. By conducting computational fluid dynamics (CFD) simulations coupled with the intake fraction iF and the daily pollutant exposure Et, this paper investigates the impact of street aspect ratios, viaducts and noise barriers on the flow and vehicular passive pollutant exposure in full-scale street canyons (H/W=1-6, W=24m)...
January 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28146128/analysis-of-temperature-and-humidity-field-in-a-new-bulk-tobacco-curing-barn-based-on-cfd
#9
Zhipeng Bai, Duoduo Guo, Shoucang Li, Yaohua Hu
A new structure bulk tobacco curing barn was presented. To study the temperature and humidity field in the new structure tobacco curing barn, a 3D transient computational fluid dynamics (CFD) model was developed using porous medium, species transport, κ-ε turbulence and discrete phase models. The CFD results demonstrated that (1) the temperature and relative humidity predictions were validated by the experimental results, and comparison of simulation results with experimental data showed a fairly close agreement; (2) the temperature of the bottom and inlet area was higher than the top and outlet area, and water vapor concentrated on the top and outlet area in the barn; (3) tobacco loading density and thickness of tobacco leaves had an explicit effect on the temperature distributions in the barn...
January 31, 2017: Sensors
https://www.readbyqxmd.com/read/28144839/yeasts-identification-in-microfluidic-devices-using-peptide-nucleic-acid-fluorescence-in-situ-hybridization-pna-fish
#10
André M Ferreira, Daniela Cruz-Moreira, Laura Cerqueira, João M Miranda, Nuno F Azevedo
Peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) is a highly specific molecular method widely used for microbial identification. Nonetheless, and due to the detection limit of this technique, a time-consuming pre-enrichment step is typically required before identification. In here we have developed a lab-on-a-chip device to concentrate cell suspensions and speed up the identification process in yeasts. The PNA-FISH protocol was optimized to target Saccharomyces cerevisiae, a common yeast that is very relevant for several types of food industries...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28139171/correlation-between-subjective-nasal-patency-and-intranasal-airflow-distribution
#11
Kevin P Casey, Azadeh A T Borojeni, Lisa J Koenig, John S Rhee, Guilherme J M Garcia
Objectives (1) Analyze the relationship between intranasal airflow distribution and subjective nasal patency in healthy and nasal airway obstruction (NAO) cohorts using computational fluid dynamics (CFD). (2) Determine whether intranasal airflow distribution is an important objective measure of airflow sensation that should be considered in future NAO virtual surgery planning. Study Design Cross-sectional. Setting Academic tertiary medical center and academic dental clinic. Subjects and Methods Three-dimensional models of nasal anatomy were created based on computed tomography scans of 15 patients with NAO and 15 healthy subjects and used to run CFD simulations of nasal airflow and mucosal cooling...
January 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28135577/piv-for-the-characterization-of-focused-field-induced-acoustic-streaming-seeding-particle-choice-evaluation
#12
Rafika Ben Haj Slama, Bruno Gilles, Maher Ben Chiekh, Jean-Christophe Béra
This research evaluates the use of Particle Image Velocimetry (PIV) technique for characterizing acoustic streaming flow generated by High Intensity Focused Ultrasound (HIFU). PIV qualification tests, focusing on the seeding particle size (diameter of 5, 20 and 50μm) were carried out in degassed water subjected to a focused field of 550kHz-frequency with an acoustic pressure amplitude of 5.2, 10.5 and 15.7bar at the focus. This study shows that the ultrasonic field, especially the radiation force, can strongly affect seeding particle behavior...
January 14, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28134131/design-and-characterization-of-a-cough-simulator
#13
Bo Zhang, Chao Zhu, Zhiming Ji, Chao-Hsin Lin
Expiratory droplets from human coughing have always been considered as potential carriers of pathogens, responsible for respiratory infectious disease transmission. To study the transmission of disease by human coughing, a transient repeatable cough simulator has been designed and built. Cough droplets are generated by different mechanisms, such as the breaking of mucus, condensation and high-speed atomization from different depths of the respiratory tract. These mechanisms in coughing produce droplets of different sizes, represented by a bimodal distribution of "fine" and "coarse" droplets...
January 30, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28129365/multi-objective-aerodynamic-optimization-of-the-streamlined-shape-of-high-speed-trains-based-on-the-kriging-model
#14
Gang Xu, Xifeng Liang, Shuanbao Yao, Dawei Chen, Zhiwei Li
Minimizing the aerodynamic drag and the lift of the train coach remains a key issue for high-speed trains. With the development of computing technology and computational fluid dynamics (CFD) in the engineering field, CFD has been successfully applied to the design process of high-speed trains. However, developing a new streamlined shape for high-speed trains with excellent aerodynamic performance requires huge computational costs. Furthermore, relationships between multiple design variables and the aerodynamic loads are seldom obtained...
2017: PloS One
https://www.readbyqxmd.com/read/28126983/combination-of-magnetic-resonance-angiography-and-computational-fluid-dynamics-may-predict-the-risk-of-stroke-in-patients-with-asymptomatic-carotid-plaques
#15
Qian Jia, Hongbin Liu, Yanping Li, Xiaoxi Wang, Jinju Jia, Yuying Li
BACKGROUND Atherosclerosis plaques in the carotid arteries frequently have been found in patients with stroke. However, the pathogenesis of carotid plaque from asymptomatic to cerebrovascular events is a complex process which is still not completely understood. We aimed to investigate the prognosis of asymptomatic carotid atherosclerotic plaques by use of magnetic resonance angiography (MRA) combined with computational fluid dynamics (CFD). MATERIAL AND METHODS We prospectively studied a cohort of 228 participants (mean age 59...
January 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28121164/herbst-appliance-effects-on-pharyngeal-airway-ventilation-evaluated-using-computational-fluid-dynamics
#16
Tomonori Iwasaki, Hideo Sato, Hokuto Suga, Ayaka Minami, Yuushi Yamamoto, Yoshihiko Takemoto, Emi Inada, Issei Saitoh, Eriko Kakuno, Ryuzo Kanomi, Youichi Yamasaki
OBJECTIVE: To evaluate the effect of a Herbst appliance on ventilation of the pharyngeal airway (PA) using computational fluid dynamics (CFD). MATERIALS AND METHODS: Twenty-one Class II patients (10 boys; mean age, 11.7 years) who required Herbst therapy with edgewise treatment underwent cone-beam computed tomography (CBCT) before and after treatment. Nineteen Class I control patients (8 boys; mean age, 11.9 years) received edgewise treatment alone. The pressure and velocity of the PA were compared between the groups using CFD based on three-dimensional CBCT images of the PA...
January 25, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28119407/blood-flow-competition-after-aortic-valve-bypass-an-evaluation-using-computational-fluid-dynamics
#17
Koji Kawahito, Naoyuki Kimura, Kenji Komiya, Masanori Nakamura, Yoshio Misawa
OBJECTIVES: Aortic valve bypass (AVB) (apico-aortic conduit) remains an effective surgical alternative for patients in whom surgical aortic valve replacement or transcatheter aortic valve implantation is not feasible. However, specific complications include thrombus formation, possibly caused by stagnation arising from flow competition between the antegrade and retrograde flow, but this has not been fully investigated. The aim of this study was to analyse flow characteristics after AVB and to elucidate mechanisms of intra-aortic thrombus using computational fluid dynamics (CFD)...
January 24, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28114192/fda-benchmark-medical-device-flow-models-for-cfd-validation
#18
Richard A Malinauskas, Prasanna Hariharan, Steven W Day, Luke H Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I Aycock, Bryan C Good, Steven Deutsch, Keefe B Manning, Brent A Craven
Computational fluid dynamics (CFD) is increasingly being used to develop blood-contacting medical devices. However, the lack of standardized methods for validating CFD simulations and blood damage predictions limits its use in the safety evaluation of devices. Through an FDA initiative, two benchmark models of typical device flow geometries (nozzle and centrifugal blood pump) were tested in multiple labs to provide experimental velocities, pressures, and hemolysis data to support CFD validation. In addition, computational simulations were performed by over 20 independent groups to assess current CFD techniques...
January 20, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28111314/three-dimensional-flow-patterns-in-the-feto-placental-vasculature-system-of-the-mouse-placenta
#19
Alexander T Shannon, Parisa Mirbod
In this study, three-dimensional (3D) blood flow of the feto-placental vasculature system of the mouse placenta was investigated using computational fluid dynamics (CFD) methods and finite element analysis. Micro-computerized tomography (micro-CT) images were used to acquire the 3D geometry of the feto-placental vasculature system, and image-processing software has been used to calculate the 3D morphology of the placenta. The flow was analyzed numerically and compared to the experimental data received from the same model...
January 19, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28110403/delayed-asymptomatic-coil-migrations-toward-different-arteries-after-aneurysmal-embolization-case-report
#20
Tomoya Kamide, Kouichi Misaki, Iku Nambu, Masanao Mohri, Naoyuki Uchiyama, Mitsutoshi Nakada
Delayed coil migration after endovascular treatment with detachable coils, particularly several months after treatment, is extremely rare. In this report, the authors describe a 77-year-old female in whom delayed coil migration to the anterior cerebral artery and posterior communicating artery (PCoA) developed 3 months after an uncomplicated aneurysm embolization. The patient was successfully retreated with a closed-cell stent. Computational fluid dynamics (CFD) revealed high wall shear stress (WSS) and multiple vortices in the residual cavity of the initially treated aneurysm...
March 2017: Acta Neurochirurgica
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