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https://www.readbyqxmd.com/read/29351045/gender-views-and-relationships-in-families-of-children-with-craniofacial-differences
#1
Danielle N Shapiro, Jennifer Waljee, Steven Buchman, Kavitha Ranganathan, Seth Warshcausky
OBJECTIVE: Gender values and beliefs are known to influence family functioning. The aim of the current study was to describe the association between views about gender and family functioning within families with a child with a craniofacial difference (CFD). DESIGN: Participants included 74 dyads composed of children (8-18 years old) with CFD (n = 36 female), including cleft lip/palate, and a parent (n = 56 female). Children and caregivers both completed the activities subscale of the Occupations, Activities, and Traits-Attitudes Measure (C/OAT-AM)...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29345035/pressure-and-pipes-from-neuroimaging-to-virtual-measurement
#2
Marialuisa Zedde, Rosario Pascarella
Leng et al. [1] described the practical application of a computational fluid dynamics (CFD) model based on Computed Tomography Angiography (CTA) in 85 patients with symptomatic atherosclerotic M1 middle cerebral artery (MCA) stenosis, to virtually measure arterial pressure (AP) across the stenotic segment, according to the theory that translesional pressure gradient (PG) drives arteriologenesis and leptomeningeal collaterals (LMC) development. This is a fundamental pathophysiological issue about the risk of recurrent stroke downstream an intracranial artery stenosis and both the degree of stenosis and the collateral circulation affect it; in WASID trial [2] patients with severe (> 70%) intracranial stenosis and efficient collaterals had a lower risk of recurrent stroke than patients with poor collaterals...
January 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29341921/computational-hydrodynamic-comparison-of-a-mini-vessel-and-a-usp-2-dissolution-testing-system-to-predict-the-dynamic-operating-conditions-for-similarity-of-dissolution-performance
#3
Bing Wang, Gerard Bredael, Piero M Armenante
The hydrodynamics characteristics of a mini vessel and a USP 2 dissolution testing system were obtained and compared to predict the tablet-liquid mass transfer coefficient from velocity distributions near the tablet and establish the dynamic operating conditions under which dissolution in mini vessels could be conducted to generate concentration profiles similar to those in the USP 2. Velocity profiles were obtained experimentally using Particle Image Velocimetry (PIV). Computational Fluid Dynamics (CFD) was used to predict the velocity distribution and strain rate around a model tablet...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29340277/comparative-computed-flow-dynamic-analysis-of-different-optimization-techniques-in-left-main-either-provisional-or-culotte-stenting
#4
Gianluca Rigatelli, Fabio Dell'Avvocata, Marco Zuin, Sara Giatti, Khanh Duong, Trung Pham, Nguyen Si Tuan, Dobrin Vassiliev, Ramesh Daggubati, Thach Nguyen
Background and Objectives: Provisional and culotte are the most commonly used techniques in left main (LM) stenting. The impact of different post-dilation techniques on fluid dynamic of LM bifurcation has not been yet investigated. The aim of this study is to evaluate, by means of computational fluid dynamic analysis (CFD), the impact of different post-dilation techniques including proximal optimization technique (POT), kissing balloon (KB), POT-Side-POT and POT-KB-POT, 2-steps Kissing (2SK) and Snuggle Kissing balloon (SKB) on flow dynamic profile after LM provisional or culotte stenting...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29338059/hemodynamic-characteristics-of-hyperplastic-remodeling-lesions-in-cerebral-aneurysms
#5
Kazuhiro Furukawa, Fujimaro Ishida, Masanori Tsuji, Yoichi Miura, Tomoyuki Kishimoto, Masato Shiba, Hiroshi Tanemura, Yasuyuki Umeda, Takanori Sano, Ryuta Yasuda, Shinichi Shimosaka, Hidenori Suzuki
BACKGROUND & PURPOSE: Hyperplastic remodeling (HR) lesions are sometimes found on cerebral aneurysm walls. Atherosclerosis is the results of HR, which may cause an adverse effect on surgical treatment for cerebral aneurysms. Previous studies have demonstrated that atherosclerotic changes had a correlation with certain hemodynamic characteristics. Therefore, we investigated local hemodynamic characteristics of HR lesions of cerebral aneurysms using computational fluid dynamics (CFD). METHODS: Twenty-four cerebral aneurysms were investigated using CFD and intraoperative video recordings...
2018: PloS One
https://www.readbyqxmd.com/read/29337433/numerical-simulation-of-two-consecutive-nasal-respiratory-cycles-toward-a-better-understanding-of-nasal-physiology
#6
Ludovic de Gabory, Nicolas Reville, Yannick Baux, Nicolas Boisson, Laurence Bordenave
BACKGROUND: Computational fluid dynamic (CFD) simulations have greatly improved the understanding of nasal physiology. We postulate that simulating the entire and repeated respiratory nasal cycles, within the whole sinonasal cavities, is mandatory to gather more accurate observations and better understand airflow patterns. METHODS: A 3-dimensional (3D) sinonasal model was constructed from a healthy adult computed tomography (CT) scan which discretized in 6.6 million cells (mean volume, 0...
January 16, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29314781/characterizing-the-fluid-dynamics-of-the-inverted-frusto-conical-shaking-bioreactor
#7
Likuan Zhu, Xueting Zhang, Kai Cheng, Zhonghua Lv, Lei Zhang, Qingyong Meng, Shujie Yuan, Boyan Song, Zhenlong Wang
We conducted a three-dimensional computational fluid dynamics (CFD) simulation to calculate the flow field in the Inverted Frusto-conical Shaking Bioreactor with 5 L working volume (IFSB-5L). The CFD models were established for the IFSB-5L at different operating conditions (different shaking speeds and filling volumes) and validated by comparison of the liquid height distribution in the agitated IFSB-5L. The "out of phase" operating conditions were characterized by analyzing the flow field in the IFSB-5L at different filling volumes and shaking speeds...
January 5, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/29314372/reduction-in-anastomotic-flow-disturbance-within-a-modified-end-to-side-arteriovenous-fistula-configuration-results-of-a-computational-flow-dynamic-model
#8
John Carroll, Ramon L Varcoe, Tracie Barber, Anne Simmons
BACKGROUND/AIMS: We sought to determine if a modification to the peri-anastomotic vein configuration during end-to-side arteriovenous fistula (AVF) creation would achieve a favorable hemodynamic environment compared with the standard acute-angle AVF. METHODS: Computational fluid dynamics (CFD) modelling of two end-to-side AVF geometries (smooth-vein-loop vs acute-angle) allowed for hemodynamic modelling. Hemodynamic fields at various stages of the pulse cycle were observed and compared across both models...
January 5, 2018: Nephrology
https://www.readbyqxmd.com/read/29313269/patient-specific-modeling-of-hemodynamics-supporting-surgical-planning-in-a-fontan-circulation-correction
#9
Theodorus M J van Bakel, Kevin D Lau, Jennifer Hirsch-Romano, Santi Trimarchi, Adam L Dorfman, C Alberto Figueroa
Computational fluid dynamics (CFD) is a modeling technique that enables calculation of the behavior of fluid flows in complex geometries. In cardiovascular medicine, CFD methods are being used to calculate patient-specific hemodynamics for a variety of applications, such as disease research, noninvasive diagnostics, medical device evaluation, and surgical planning. This paper provides a concise overview of the methods to perform patient-specific computational analyses using clinical data, followed by a case study where CFD-supported surgical planning is presented in a patient with Fontan circulation complicated by unilateral pulmonary arteriovenous malformations...
January 8, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29305603/assessing-airflow-sensitivity-to-healthy-and-diseased-lung-conditions-in-a-computational-fluid-dynamics-model-validated-in-vitro
#10
Bora Sul, Zachary Oppito, Shehan Jayasekera, Brian Vanger, Amy Zeller, Michael Morris, Kai Ruppert, Talissa Altes, Vineet Rakesh, Steven Day, Risa J Robinson, Jaques Reifman, Anders Wallqvist
Computational models are useful for understanding respiratory physiology. Crucial to such models are the boundary conditions specifying the flow conditions at truncated airway branches (terminal flow rates). However, most studies make assumptions about these values, which are difficult to obtain in vivo. We developed a computational fluid dynamics (CFD) model of airflows for steady expiration to investigate how terminal flows affect airflow patterns in respiratory airways. First, we measured in vitro airflow patterns in a physical airway model, using particle image velocimetry...
January 5, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29304062/phase-contrast-mri-versus-numerical-simulation-to-quantify-hemodynamical-changes-in-cerebral-aneurysms-after-flow-diverter-treatment
#11
Sergey Sindeev, Philipp Georg Arnold, Sergey Frolov, Sascha Prothmann, Dieter Liepsch, Andrea Balasso, Philipp Berg, Stephan Kaczmarz, Jan Stefan Kirschke
Cerebral aneurysms are a major risk factor for intracranial bleeding with devastating consequences for the patient. One recently established treatment is the implantation of flow-diverters (FD). Methods to predict their treatment success before or directly after implantation are not well investigated yet. The aim of this work was to quantitatively study hemodynamic parameters in patient-specific models of treated cerebral aneurysms and its correlation with the clinical outcome. Hemodynamics were evaluated using both computational fluid dynamics (CFD) and phase contrast (PC) MRI...
2018: PloS One
https://www.readbyqxmd.com/read/29297393/substance-deposition-assessment-in-obstructed-pulmonary-system-through-numerical-characterization-of-airflow-and-inhaled-particles-attributes
#12
Antonios Lalas, Stavros Nousias, Dimitrios Kikidis, Aris Lalos, Gerasimos Arvanitis, Christos Sougles, Konstantinos Moustakas, Konstantinos Votis, Sylvia Verbanck, Omar Usmani, Dimitrios Tzovaras
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are considered as the two most widespread obstructive lung diseases, whereas they affect more than 500 million people worldwide. Unfortunately, the requirement for detailed geometric models of the lungs in combination with the increased computational resources needed for the simulation of the breathing did not allow great progress to be made in the past for the better understanding of inflammatory diseases of the airways through detailed modelling approaches...
December 20, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29290064/the-impacts-of-the-axial-to-radial-airflow-quantity-ratio-and-suction-distance-on-air-curtain-dust-control-in-a-fully-mechanized-coal-face
#13
Hao Wang, Weimin Cheng, Biao Sun, Haiming Yu, Hu Jin
To understand the impacts of the axial-to-radial airflow quantity ratio (denoted as R) and the suction distance (denoted as Ds) on air curtain dust control in a fully mechanized coal face, the 3down610 coal face in Jiangzhuang coal mine was numerically simulated in this study. A mathematic model was established to describe the airflow migration and dust diffusion in a coal face, and a scaled physical model was constructed. The comparison between simulation results and field measurements validated the model and the parameter settings...
December 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29284057/computational-fluid-dynamics-cfd-using-porous-media-modeling-predicts-recurrence-after-coiling-of-cerebral-aneurysms
#14
Yasuyuki Umeda, Fujimaro Ishida, Masanori Tsuji, Kazuhiro Furukawa, Masato Shiba, Ryuta Yasuda, Naoki Toma, Hiroshi Sakaida, Hidenori Suzuki
OBJECTIVE: This study aimed to predict recurrence after coil embolization of unruptured cerebral aneurysms with computational fluid dynamics (CFD) using porous media modeling (porous media CFD). METHOD: A total of 37 unruptured cerebral aneurysms treated with coiling were analyzed using follow-up angiograms, simulated CFD prior to coiling (control CFD), and porous media CFD. Coiled aneurysms were classified into stable or recurrence groups according to follow-up angiogram findings...
2017: PloS One
https://www.readbyqxmd.com/read/29278828/influence-of-slosh-baffles-on-thermodynamic-performance-in-liquid-hydrogen-tank
#15
Zhan Liu, Cui Li
A calibrated CFD model is built to investigate the influence of slosh baffles on the pressurization performance in liquid hydrogen (LH2) tank. The calibrated CFD model is proven to have great predictive ability by compared against the flight experimental results. The pressure increase, thermal stratification and wall heat transfer coefficient of LH2 tank have been detailedly studied. The results indicate that slosh baffles have a great influence on tank pressure increase, fluid temperature distribution and wall heat transfer...
December 19, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29278727/application-of-cfd-in-bioprocessing-separation-of-mammalian-cells-using-disc-stack-centrifuge-during-production-of-biotherapeutics
#16
Lalita Kanwar Shekhawat, Jayati Sarkar, Rachit Gupta, Sandeep Hadpe, Anurag S Rathore
Centrifugation continues to be one of the most commonly used unit operations for achieving efficient harvest of the product from the mammalian cell culture broth during production of therapeutic monoclonal antibodies (mAbs). Since the mammalian cells are known to be shear sensitive, optimal performance of the centrifuge requires a balance between productivity and shear. In this study, Computational Fluid Dynamics (CFD) has been successfully used as a tool to facilitate efficient optimization. Multiphase Eulerian-Eulerian model coupled with Gidaspow drag model along with k-ε mixture turbulence model have been used to quantify the complex hydrodynamics of the centrifuge and thus evaluate the turbulent stresses generated by the centrifugal forces...
December 23, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29274303/magnetic-drug-targeting-simulations-in-blood-flows-with-fluid-structure-interaction
#17
S Calandrini, G Capodaglio, E Aulisa
We present fluid-structure interaction (FSI) simulations of magnetic drug targeting (MDT) in blood flows. In this procedure, a drug is attached to ferromagnetic particles in order to externally direct it to a specific target after it is injected inside the body. The goal is to minimize the healthy tissue affected by the treatment and to maximize the number of particles that reach the target location. MDT has been studied both experimentally and theoretically by several authors. In recent years, computational fluid dynamics (CFD) simulations of MDT in blood flows have been carried out to obtain further insight on the combination of parameters that provide the best capture efficiency...
December 23, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29259122/hemodynamics-and-coil-distribution-with-changing-coil-stiffness-and-length-in-intracranial-aneurysms
#18
Soichiro Fujimura, Hiroyuki Takao, Takashi Suzuki, Chihebeddine Dahmani, Toshihiro Ishibashi, Hiroya Mamori, Makoto Yamamoto, Yuichi Murayama
PURPOSE: The purpose of this study was to investigate hemodynamics and coil distribution with changing coil stiffness and length using the finite element method (FEM) and computational fluid dynamics (CFD) analysis. METHODS: Basic side-wall and bifurcation type aneurysm models were used. Six types of coil models were generated by changing the coil stiffness and length, based on commercially available embolic coils. Coil embolization was simulated using FEM. CFD was performed to characterize the hemodynamics in the aneurysms after embolization...
December 19, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29259020/genetic-risk-factors-for-late-age-related-macular-degeneration-in-india
#19
Anand Rajendran, Pankaja Dhoble, Periasamy Sundaresan, Vijayan Saravanan, Praveen Vashist, Dorothea Nitsch, Liam Smeeth, Usha Chakravarthy, Ravilla D Ravindran, Astrid E Fletcher
BACKGROUND/AIMS: There are limited data from India on genetic variants influencing late age-related macular degeneration (AMD). We have previously reported associations from a population-based study in India (the India age-related eye disease study (INDEYE)) of early AMD and single nucleotide polymorphisms (SNPs) in ARMS2/HTRA1 and no association with CFH, C2 or CFB. Late AMD cases were too few for meaningful analyses. We aimed to investigate SNPs for late AMD through case enrichment and extend the loci for early AMD...
December 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29249029/efficient-fluoride-removal-using-al-cu-oxide-nanoparticles-supported-on-steel-slag-industrial-waste-solid
#20
Alien Blanco-Flores, Nubia Arteaga-Larios, Víctor Pérez-García, José Martínez-Gutiérrez, María Ojeda-Escamilla, Israel Rodríguez-Torres
A SSW/Al-Cu formed from an industrial solid waste and Al-Cu Nps are utilized for the removal of fluoride from aqueous solutions. The SSW/Al-Cu was obtained by a chemical reduction method. The SSW/Al-Cu was characterized by TEM, SEM, FT-IR, XRD, BET, and pHzpc techniques. The Nps were formed as bimetallic oxides and deposited in the form of spheroidal particles forming agglomerations. The sizes of these particles range from 1 to 3 nm. The surface area and average pore width of SSW/Al-Cu were 2.99 m2/g and 17...
December 16, 2017: Environmental Science and Pollution Research International
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