keyword
https://read.qxmd.com/read/38487683/advances-in-biomarkers-for-vasospasm-towards-a-future-blood-based-diagnostic-test
#21
REVIEW
Aditya M Mittal, Kamil W Nowicki, Rohit Mantena, Catherine Cao, Emma K Rochlin, Robert Dembinski, Michael J Lang, Bradley A Gross, Robert M Friedlander
OBJECTIVE: Cerebral vasospasm and the resultant delayed cerebral infarction is a significant source of mortality following aneurysmal SAH. Vasospasm is currently detected using invasive or expensive imaging at regular intervals in patients following SAH, thus posing a risk of complications following the procedure and financial burden on these patients. Currently, there is no blood-based test to detect vasospasm. METHODS: PubMed, Web of Science, and Embase databases were systematically searched to retrieve studies related to cerebral vasospasm, aneurysm rupture, and biomarkers...
April 2024: World neurosurgery: X
https://read.qxmd.com/read/38487644/hybrid-approach-to-management-for-a-patient-with-culture-negative-infective-endocarditis-with-profunda-femoris-mycotic-pseudoaneurysm-a-case-report-and-review-of-the-literature
#22
Fahad M Alshair, Abdullah H Baghaffar, Mazin A Fatani, Reda A Jamjoom
Mycotic pseudoaneurysms can be a serious and life threatening complication of left sided infective endocarditis. They most commonly affect the major axial vessels. Profunda femoris artery (PFA) aneurysms are rare and present in only 0.5% of all peripheral aneurysms, regardless of the underlying etiology. We present a case of a patient who underwent mitral valve repair for severe mitral regurgitation secondary to culture negative IE which was complicated by multiple mycotic pseudoaneurysm. The PFA pseudoaneurysm which was affected and was complicated with a large hematoma compressing the femoral nerve...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38487587/surgical-ventricular-reconstruction-and-intraoperative-cryoablation-in-a-patient-with-drug-refractory-ventricular-tachycardia-and-left-ventricular-thrombus-a-case-report
#23
Maryuri Delgado Lopez, Julia Vogler, Anas Aboud, Christian-Hendrik Heeger, Roland Richard Tilz
BACKGROUND: Despite modern techniques for ablation of ventricular tachycardia (VT), the procedure faces challenges such as deep intramural substrates or inaccessibility of the pericardial space. We aim to present a case of successful surgical treatment of a patient with drug-refractory VT, an apical aneurysm, large left ventricular (LV) thrombus, and recurrent implantable cardioverter defibrillator (ICD) shocks following failed epicardial catheter ablation. CASE SUMMARY: A 67-year-old male with a history of ischaemic cardiomyopathy was brought to the emergency room after a syncope because of VT...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38487515/safety-of-preoperative-branch-embolization-in-patients-undergoing-evar
#24
REVIEW
Luis Ángel Suárez González, Iñigo Lozano Martínez-Luengas, Pablo Del Canto Peruyera, Manuel Javier Vallina-Victorero Vazquez
The purpose of this systematic review is to evaluate the safety of pre-endovascular abdominal aortic aneurysm repair (EVAR) embolization of aortic side branches - the inferior mesenteric artery and lumbar arteries. Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed. A search of MEDLINE and DIMENSION databases identified 9 studies published from 2011 to 2021 that satisfied the inclusion and exclusion criteria. These studies were analyzed to detect the incidence of embolization-related complications...
2024: Jornal Vascular Brasileiro
https://read.qxmd.com/read/38487396/intercostal-artery-aneurysm-presenting-as-a-spontaneous-hemothorax-in-a-patient-with-neurofibromatosis
#25
Harsimran Panesar, Geoffrey Pelz, Daniel Mansour
Beyond the commonly known clinical presentation of neurofibromatosis, vascular pathologies are increasingly becoming a known complication. We present a case of a 41-year-old adult with neurofibromatosis type 1 who came with a right-sided spontaneous hemothorax due to a ruptured 13-mm fusiform aneurysm of the right posterior T9 intercostal artery. Patient underwent a transcatheter angiographic embolization with subsequent video-assisted thoracic surgery (VATS) for a retained hemothorax. Patient was discharged home on Hospital Day 5, and follow-up imaging demonstrated a complete resolution of the hemothorax...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38487140/surgical-treatment-of-a-giant-proximal-ulnar-artery-aneurysm-potentially-associated-with-subacute-endocarditis
#26
Vangelis Bontinis, Alkis Bontinis, Argirios Giannopoulos, Vasiliki Manaki, Ioannis Kontes, Kyriakos Ktenidis
Ulnar artery aneurysms (UAAs), although infrequent, pose limited challenges in terms of timely diagnosis and surgical intervention. Their intricacy lies in discerning and addressing the underlying pathology, often necessitating prolonged hospitalization. Herein, we present a case detailing a giant aneurysm located in the proximal ulnar artery, measuring 5.2 cm in diameter. The patient exhibited negative microbial cultures and non-pathological transthoracic echocardiography (TTE). Successful treatment involved aneurysmal exclusion and saphenous vein graft interposition...
February 2024: Curēus
https://read.qxmd.com/read/38487044/female-specific-considerations-in-aortic-health-and-disease
#27
REVIEW
Rebecca Crosier, Maria Agustina Lopez Laporte, Rudy R Unni, Thais Coutinho
The aorta plays a central role in the modulation of blood flow to supply end organs and to optimize the workload of the left ventricle. The constant interaction of the arterial wall with protective and deleterious circulating factors, and the cumulative exposure to ventriculoarterial pulsatile load, with its associated intimal-medial changes, are important players in the complex process of vascular aging. Vascular aging is also modulated by biomolecular processes such as oxidative stress, genomic instability, and cellular senescence...
February 2024: CJC open
https://read.qxmd.com/read/38487034/acute-dissection-of-a-syphilitic-saccular-aneurysm-of-the-ascending-aorta-and-arch-in-a-hypertensive-patient-a-rare-phenomenon
#28
Hubert Daisley, Dennecia George, Johann Daisley
We report the case of a 77-year-old male who suffered from hypertension and died suddenly. At autopsy, he was found to have hypertensive cardiomegaly and a dissecting syphilitic saccular aneurysm of the ascending aorta and arch with tamponade. Chronic aortic regurgitation, which is often seen in syphilitic aortitis, produces an additive effect to the concentric left ventricular hypertrophy seen in hypertension.
2024: Autopsy & Case Reports
https://read.qxmd.com/read/38486761/construction-and-validation-of-a-perioperative-concomitant-lower-extremity-deep-vein-thrombosis-line-graph-model-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#29
JOURNAL ARTICLE
Daiqi Xu, Han Xiong, Shizhen Cui, Jiahe Tan, Yinrui Ma, Zhaohui He
BACKGROUND: To develop and validate a nomogram for predicting the probability of deep venous thrombosis (DVT) in patients with aneurysmal subarachnoid hemorrhage (aSAH) during the perioperative period, using clinical features and readily available biochemical parameters. METHODS: The least absolute shrinkage and selection operator (LASSO) regression technique was employed for data dimensionality reduction and selection of predictive factors. A multivariable logistic regression analysis was conducted to establish a predictive model and nomogram for post-aSAH DVT...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38486025/a-yeast-based-assay-establishes-the-pathogenicity-of-novel-missense-acta2-variants-associated-with-aortic-aneurysms
#30
JOURNAL ARTICLE
Cristina Calderan, Ugo Sorrentino, Luca Persano, Eva Trevisson, Geppo Sartori, Leonardo Salviati, Maria Andrea Desbats
The ACTA2 gene codes for alpha-smooth muscle actin, a critical component of the contractile apparatus of the vascular smooth muscle cells. Autosomal dominant variants in the ACTA2 gene have been associated to familial non-syndromic thoracic aortic aneurysm/dissection (TAAD). They are thought to act through a dominant-negative mechanism. These variants display incomplete penetrance and variable expressivity, complicating the validation of ACTA2 variants pathogenicity by family segregation studies. In this study, we developed a yeast based assay to test putative TAAD-associated ACTA2 variants...
March 15, 2024: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/38485964/mendelian-randomization-study-on-insulin-resistance-and-risk-of-hypertension-and-cardiovascular-disease
#31
JOURNAL ARTICLE
Fangfang Zhang, Zhimin Yu
Observational studies have suggested that insulin resistance (IR) is associated with hypertension and various cardiovascular diseases. However, the presence of a causal relationship between IR and cardiovascular disease remains unclear. Here, we applied Mendelian randomization (MR) approaches to address the causal association between genetically determined IR and the risk of cardiovascular diseases. Our primary genetic instruments comprised 53 SNPs associated with IR phenotype from a GWAS of up to 188,577 participants...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38485905/unraveling-the-impact-of-blood-transfusion-on-transcription-factors-regulating-t-helper-1-2-17-and-regulatory-t-cells
#32
JOURNAL ARTICLE
Samad Valizadeh, Azita Chegini, Faranak Behnaz, Ali Akbar Pourfatollah, Shahram Samiee, Ronak Karbalaeifar
T helper 1 (TH1) and TH2 lymphocytes are the most important components of the immune system affected by blood transfusion. This study aimed`` to evaluate the effect of blood transfusion on gene expression of transcription factors related to the development of TH1, TH2, TH17 and regulatory T cells (Tregs). In this cross-sectional study, 20 patients diagnosed with abdominal aortic aneurysms requiring surgical repair were studied from January 2018 to August 2020. We utilized real-time PCR to evaluate the expression of transcription factor genes associated with TH1, TH2, TH17, and Treg, namely T-box-expressed-in-T-cells (T-bet), GATA-binding protein 3 (GATA-3), retinoid-related orphan receptor (RORγt), and fork head box protein 3 (Foxp3), respectively...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485879/prospective-observational-study-of-volatile-sedation-with-sevoflurane-after-aneurysmal-subarachnoid-hemorrhage-using-the-sedaconda-anesthetic-conserving-device
#33
JOURNAL ARTICLE
Jan Leppert, Jan Küchler, Andreas Wagner, Niclas Hinselmann, Claudia Ditz
BACKGROUND: Volatile sedation is still used with caution in patients with acute brain injury because of safety concerns. We analyzed the effects of sevoflurane sedation on systemic and cerebral parameters measured by multimodal neuromonitoring in patients after aneurysmal subarachnoid hemorrhage (aSAH) with normal baseline intracranial pressure (ICP). METHODS: In this prospective observational study, we analyzed a 12-h period before and after the switch from intravenous to volatile sedation with sevoflurane using the Sedaconda Anesthetic Conserving Device with a target Richmond Agitation Sedation Scale score of - 5 to - 4...
March 14, 2024: Neurocritical Care
https://read.qxmd.com/read/38485809/successful-management-of-splenic-artery-dissection-after-sigmoid-colon-perforation-in-vascular-ehlers-danlos-syndrome
#34
JOURNAL ARTICLE
Moegi Yoshizaki, Yasuko Matsuo, Satoshi Yasuda, Shunsuke Doi, Takeshi Sakata, Minako Nagai, Kota Nakamura, Yuichiro Kohara, Shohei Toyoda, Toshihiro Tanaka, Masayuki Sho
BACKGROUND: Ehlers-Danlos syndrome (EDS) is a genetic disorder that causes fragility of the systemic connective tissues. Of the 13 subtypes, vascular EDS (vEDS) is associated with abnormalities in collagen production, resulting in arterial rupture and intestinal perforation. Herein, we report the case of a man with confirmed vEDS who survived a ruptured dissected splenic artery aneurysm triggered by perforation of the sigmoid colon. CASE PRESENTATION: A 48-year-old man presented to our hospital with sudden severe lower abdominal pain...
March 15, 2024: Surgical Case Reports
https://read.qxmd.com/read/38485695/six-year-clinical-and-computed-tomography-angiography-follow-up-after-nexus-implantation
#35
JOURNAL ARTICLE
Augusto D'Onofrio, Michele Antonello, Michele Piazza, Gino Gerosa
Endovascular aortic arch repair (Ar-TEVAR) with single-branch, off-the-shelf Nexus aortic arch system has shown promising early and 3-year outcomes. There is lack of data regarding long-term results of this specific device, particularly regarding patency of supra-aortic bypasses and stability of the connection between the two modules. This case report describes 6-year clinical and imaging follow-up of a 74-year old patient who underwent Ar-TEVAR with Nexus. Over six years, the patient experienced minor complications unrelated to the device...
March 14, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38485319/loeys-dietz-syndrome-with-a-novel-in-frame-smad3-deletion-diagnosed-as-a-result-of-postpartum-aortic-dissection-a-case-report
#36
Takeshi Nagao, Momoko Inoue, Yuki Ito, Takashi Kunihara, Hiroshi Kawame, Osamu Samura, Aikou Okamoto
OBJECTIVE: Loeys-Dietz syndrome (LDS) is a rare, autosomal dominant connective tissue disorder which can aggressively affect the aortic vasculature. Limited information is available regarding its impact on pregnancy and postpartum outcomes. CASE REPORT: A pregnant 38-year-old nulliparous woman with mild aortic regurgitation and family history of aortic aneurysms presented with an aortic root measuring 49 mm. Despite concerns of an underlying connective tissue disorder, a definitive diagnosis was not reached...
March 2024: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/38485121/incidence-presentation-and-outcome-of-acute-aortic-dissection-results-from-a-population-based-study
#37
JOURNAL ARTICLE
Christian Smedberg, Rebecka Hultgren, Christian Olsson, Johnny Steuer
OBJECTIVES: To describe the incidence of acute aortic dissection in a clearly defined population, to assess onset symptoms and admission biochemical marker levels and to analyse variables potentially associated to mortality. METHODS: Medical records and CT angiograms of all patients hospitalised for acute aortic dissection in the Stockholm County during the 5-year period 2012-2016 were reviewed. The patients were followed until date of death or until 31 December 2020...
March 13, 2024: Open Heart
https://read.qxmd.com/read/38485071/evaluating-growth-patterns-of-abdominal-aortic-aneurysms-among-women
#38
JOURNAL ARTICLE
Kathryn DiLosa, Gregory Brittenham, Cara Pozolo, Nasim Hedayati, Mimmie Kwong, Steven Maximus, Misty Humphries
OBJECTIVES: Though initially protected from vessel dilation by estrogen, women may experience rapid abdominal aortic aneurysm (AAA) growth post-menopause. The rate of growth has been poorly defined in prior literature. Here we describe aneurysm growth in a cohort of women found through an AAA screening program. METHODS: Women with AAA were retrospectively identified. Aortic imaging was reviewed, and measurements of maximum transverse and anterior-posterior diameters were completed...
March 12, 2024: Journal of Vascular Surgery
https://read.qxmd.com/read/38485069/ten-year-single-center-outcomes-following-endovascular-repair-for-abdominal-aortic-aneurysm-using-the-incraft-device
#39
JOURNAL ARTICLE
Hirotsugu Ozawa, Takao Ohki, Kota Shukuzawa, Kentaro Kasa, Yuta Yamada, Hikaru Nakagawa, Miyo Shirouzu, Makiko Omori, Soichiro Fukushima, Hiromasa Tachihara
OBJECTIVE: This study aimed to report the long-term outcomes beyond 10 years of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs) using the low-profile INCRAFT device. METHODS: This was a single-center, retrospective cohort study of all patients undergoing EVAR using the INCRAFT device as part of the regulatory trial between 2012 and 2013. Primary endpoint was aneurysm-related death. Secondary endpoints were all-cause death, reintervention, late open conversion, and aneurysm status (shrinkage, stable, and growth)...
March 12, 2024: Journal of Vascular Surgery
https://read.qxmd.com/read/38485045/stuck-in-the-middle-type-ib-endoleak-after-endovascular-aortic-aneurysm-repair
#40
JOURNAL ARTICLE
Stephanie Rassam, Siegmund Guggenbichler
No abstract text is available yet for this article.
March 12, 2024: European Journal of Vascular and Endovascular Surgery
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