Read by QxMD icon Read


Bijoy G Rajbanshi, Dikshya Joshi, Sidhartha Pradhan, Navin C Gautam, Rabindra Timala, Urmila Shakya, Apurb Sharma, Gangaram Biswakarma, Jyotindra Sharma
OBJECTIVES: Coarctation of the aorta is known to present with hypertension in older patients; we reviewed our experience and assessed the outcome of hypertension following surgical correction. METHODS: From April 2004 to date, 43 patients above the age of 12 underwent coarctation of the aorta repair. The mean age was 20.4 + 9.7 years (maximum 56 years); 21 (48.8%) were older than 18 years and 28 (65.1%) were men. Thirty (69.8%) patients had hypertension...
June 22, 2018: European Journal of Cardio-thoracic Surgery
Athiel Yoann, Barrois Mathilde, Bault Jean-Philippe, Cohen Laurence, Leroy Brigitte, Quibel Thibaud
Congenital ventricular aneurysms and diverticula are rare congenital heart diseases, currently accessible to prenatal diagnosis. Information on the natural course of ventricular aneurysm or diverticulum detected during fetal life is limited as there are only few case reports and case series enumerating the defect. We aimed to describe through three cases, the prenatal features and clinical outcomes of fetal cardiac aneurysms. The first one was diagnosed during the second trimestrer and spontaneous evolution was favorable...
June 19, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Ali Tayebi Meybodi, Arnau Benet, Vera Vigo, Roberto Rodriguez Rubio, Sonia Yousef, Pooneh Mokhtari, Flavia Dones, Sofia Kakaizada, Michael T Lawton
OBJECTIVE The expanded endoscopic endonasal approach (EEA) has shown promising results in treatment of midline skull base lesions. Several case reports exist on the utilization of the EEA for treatment of aneurysms. However, a comparison of this approach with the classic transcranial orbitozygomatic approach to the basilar apex (BAX) region is missing. The present study summarizes the results of a series of cadaveric surgical simulations for assessment of the EEA to the BAX region for aneurysm clipping and its comparison with the transcranial orbitozygomatic approach as one of the most common approaches used to treat BAX aneurysms...
June 22, 2018: Journal of Neurosurgery
Eric S Nussbaum, Michael T Madison, James K Goddard, Jeffrey P Lassig, Kevin M Kallmes, Leslie A Nussbaum
OBJECTIVE Advances in endovascular therapy for the treatment of middle cerebral artery (MCA) aneurysms have led to scrutiny of its benefits compared with microsurgical repair. To provide information regarding complication rates and outcomes, the authors reviewed the results of a large series of unruptured MCA aneurysms treated with open microsurgery. METHODS The authors included all patients who underwent surgical repair of an unruptured MCA aneurysm between 1997 and 2015. All surgical procedures, including clipping, wrapping, bypass, and parent artery occlusion, were performed by a single neurosurgeon...
June 22, 2018: Journal of Neurosurgery
Michael A Silva, Alfred P See, Priyank Khandelwal, Ashutosh Mahapatra, Kai U Frerichs, Rose Du, Nirav J Patel, Mohammad A Aziz-Sultan
OBJECTIVE Paraclinoid aneurysms represent approximately 5% of intracranial aneurysms (Drake et al. [1968]). Visual impairment, which occurs in 16%-40% of patients, is among the most common presentations of these aneurysms (Day [1990], Lai and Morgan [2013], Sahlein et al. [2015], and Silva et al. [2017]). Flow-diverting stents, such as the Pipeline Embolization Device (PED), are increasingly used to treat these aneurysms, in part because of their theoretical reduction of mass effect (Fiorella et al. [2009])...
June 22, 2018: Journal of Neurosurgery
Osman Ocal, Mustafa Yilmaz, Bora Peynircioglu, Burcak Bilginer, Ahmet Peker, Anil Arat
Aneurysms of the extracranial internal carotid artery (ICA) in pediatric patients are rare and mostly treated surgically. The authors present the case of a child with a giant extracranial ICA aneurysm presenting with gradual airway compression. A plan was made to explore the aneurysm surgically and straighten the associated carotid artery kinks during the operation to enable further endovascular treatment if primary reconstruction of the carotid artery proved not to be possible. Finally, the aneurysm was successfully treated with staged hybrid intervention, which consisted of surgical correction of parent artery kinks followed by endovascular implantation of stent grafts...
June 22, 2018: Journal of Neurosurgery. Pediatrics
Satomi Kasashima, Atsuhiro Kawashima, Fuminori Kasashima, Masamitsu Endo, Yasushi Matsumoto, Kengo Kawakami
Immunoglobulin (IgG) 4-related diseases (IgG4-RDs) are fibro-inflammatory conditions characterized by tumorous swelling and serum IgG4 levels. Intrapelvic IgG4-RD has been subclassified according to the localization site and aortic shape as IgG4-related aortic aneurysms (IgG4-AAs), periaortitis (IgG4-PA), and retroperitoneal fibrosis (IgG4-RF). The IgG4-AA pathogenesis would involve interleukin (IL)-6 upregulation, and Th2-predominant and Treg-activated immune conditions. We characterized the features of intrapelvic IgG4-RD lesions, including presence of vascular lesions...
June 21, 2018: Heart and Vessels
Tim Van Damme, Xiaomeng Pang, Brecht Guillemyn, Sandrine Gulberti, Delfien Syx, Riet De Rycke, Olivier Kaye, Christine E M de Die-Smulders, Rolph Pfundt, Ariana Kariminejad, Sheela Nampoothiri, Geneviève Pierquin, Saskia Bulk, Austin A Larson, Kathryn C Chatfield, Marleen Simon, Anne Legrand, Marion Gerard, Sofie Symoens, Sylvie Fournel-Gigleux, Fransiska Malfait
Proteoglycans are among the most abundant and structurally complex biomacromolecules and play critical roles in connective tissues. They are composed of a core protein onto which glycosaminoglycan (GAG) side chains are attached via a linker region. Biallelic mutations in B3GALT6, encoding one of the linker region glycosyltransferases, are known to cause either spondyloepimetaphyseal dysplasia (SEMD) or a severe pleiotropic form of Ehlers-Danlos syndromes (EDS). This study provides clinical, molecular and biochemical data on 12 patients with biallelic B3GALT6 mutations...
June 20, 2018: Human Molecular Genetics
I van der Pluijm, J Burger, P M van Heijningen, A IJpma, N van Vliet, C Milanese, K Schoonderwoerd, W Sluiter, L J Ringuette, D H W Dekkers, I Que, E L Kaijzel, L Te Riet, E MacFarlane, D Das, R van der Linden, M Vermeij, J A Demmers, P G Mastroberardino, E C Davis, H Yanagisawa, H Dietz, R Kanaar, J Essers
Aim: Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To discover novel robust biomarkers, we aimed to better understand the molecular mechanisms underlying aneurysm formation. Methods and Results: In Fibulin-4R/R mice, the extracellular matrix protein Fibulin-4 is 4-fold reduced, resulting in progressive ascending aneurysm formation and early death around 3 months of age. We performed proteomics and genomics studies on Fibulin-4R/R mouse aortas...
June 21, 2018: Cardiovascular Research
Kyawzaw Lin, Aung Naing Lin, Won Jun Park, Pwint Phyu Hlaing, Cesar Ayala-Rodriguez
Splenic infarction is an unusual cause for a patient to present with left upper abdomen pain. A 47-year-old woman presented to the emergency department with left upper abdomen pain. She reported that she stopped taking warfarin two days prior to presentation. A physical examination revealed fine crackles within the left lower lobe and significant tenderness within the left upper abdomen. Computed tomography of the abdomen showed mild cardiomegaly with a 2.3 cm calcified thrombus in the left ventricular apex...
April 19, 2018: Curēus
Burke A Cunha, Ismail Jimada, Karishma Chawla
Background: Infectious endocarditis (IE) clinically manifests as either subacute bacterial endocarditis (SBE) or acute bacterial endocarditis (ABE). Neurologic manifestations are markedly different for these two entities. ABE is caused by invasive, highly virulent pathogens (e.g., Staphylococcus aureus ), whereas SBE is attributed to relatively avirulent, non-invasive organisms (e.g., viridans streptococci ). Methods: Here, we reviewed the clinical and radiographic presentations of a patient with cranial complications attributed to ABE...
2018: Surgical Neurology International
Yoshiji Yamada, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Tetsuo Fujimaki, Yoshiki Yasukochi, Ichiro Takeuchi, Jun Sakuma
Given that substantial genetic components have been shown in ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH), heritability may be higher in early-onset than late-onset individuals with these conditions. Although genome-wide association studies (GWASs) have identified various genes and loci significantly associated with ischemic stroke, ICH, or intracranial aneurysm mainly in European ancestry populations, genetic variants that contribute to susceptibility to these disorders remain to be identified definitively...
July 2018: Biomedical Reports
Erol Kurç, Onur Sokullu, Serdar Akansel, Murat Sargın
Despite technological advances, the long-term outcomes of endovascular aortic aneurysm repair (EVAR) are still debatable. Although most endograft failures after EVAR can be corrected with endovascular techniques, open conversion may still be required. A 70-year-old male patient presented at the emergency unit with abdominal pain. Twice, in the third and fourth years after the first repair, a stent graft had been placed over a non-adhesive portion of the stent graft due to type Ia endoleaks. In the most recent admission, a CT scan showed type III endoleak and ruptured aneurysm sac...
January 2018: Jornal Vascular Brasileiro
Tulio Fabiano de Oliveira Leite, Lucas Alves Sarmento Pires, Rafael Cisne, Marcio Antonio Babinski, Carlos Alberto Araujo Chagas
The right subclavian artery may originate from the left portion of the aortic arch. This aberrant vessel is known as the arteria lusoria. Its course to its usual site runs behind the esophagus, which may cause a disease known as dysphagia lusoria, responsible for symptoms of discomfort. This artery is often associated with other anomalies, such as the non-recurrent laryngeal nerve and the bicarotid trunk, and with diseases such as aneurysms, congenital heart defects, and even genetic syndromes. During routine dissection of a male cadaver fixed in 10% formalin solution, an arteria lusoria was found...
October 2017: Jornal Vascular Brasileiro
Ralf Robert Kolvenbach
Thoracoabdominal aortic aneurysms (TAAA) present special challenges for repair due to their extent, their distinctive pathology, and the fact that they typically cross the ostia of one or more visceral branch vessels. Historically, the established treatment for TAAA was open surgical repair, with the first procedure reported in 1955. Endovascular repair of TAAA with fenestrated and/ or branched endografts, has been studied since the beginning of the current century as a means of mechanical aneurysm exclusion...
October 2017: Jornal Vascular Brasileiro
Bartosz Sokół, Bartosz Urbaniak, Norbert Wąsik, Szymon Plewa, Agnieszka Klupczyńska, Roman Jankowski, Barbara Więckowska, Robert Juszkat, Zenon Kokot
[This corrects the article on p. 438 in vol. 8, PMID: 28894433.].
2018: Frontiers in Neurology
Takayuki Anno, Nobuyuki Kobayashi, Takehiko Yamaguchi
We report a rare case of an unruptured cerebral aneurysm in the left distal middle cerebral artery(MCA). A 76-year-old woman was referred to our department for unruptured cerebral aneurysms detected incidentally by magnetic resonance angiography. A left carotid angiogram revealed a saccular aneurysm arising in an arterial trunk unrelated to the branching zone of the distal MCA. The patient underwent an operation for trapping and excision of the saccular aneurysm in the distal MCA followed by end-to-end anastomosis...
June 2018: No Shinkei Geka. Neurological Surgery
Mengcheng Shen, Mei Hu, Paul W Fedak, Gavin Y Oudit, Zamaneh Kassiri
<u>Rationale:</u> Disintegrin and metalloproteinase-17 (ADAM17) is a membrane-bound enzyme that regulates bioavailability of multiple transmembrane proteins by proteolytic processing. ADAM17 has been linked to a number of pathologies, but its role in thoracic aortic aneurysm (TAA) has not been determined. <u>Objective:</u> To explore the cell-specific functions of vascular ADAM17 in the pathogenesis and progression of TAA. <u>Methods and Results:</u> In aneurysmal thoracic aorta from patients, ADAM17 was increased in tunica media and intima...
June 21, 2018: Circulation Research
Clinton S Robbins, John S Byrne
The pathogenesis of thoracic aortic aneurysm and dissection (TAAD) is complex and incompletely understood. The hallmarks of the disease process are aortic inflammatory cell infiltration and protease mediated elastic fiber disruption. In a study recently published in Clinical Science (2018) 132 (6), 655-668), Liu et al explore the mechanism through which aortic vascular smooth cells and macrophages participate in TAAD using a mouse model. The authors propose that interleukin-3 (IL-3) released from aortic vascular smooth cells is central to the disease process...
June 29, 2018: Clinical Science (1979-)
S Keisin Wang, Natalie A Drucker, Michael C Dalsing, Alan P Sawchuk, Alok K Gupta, Raghu L Motaganahalli, Michael P Murphy, Andres Fajardo
OBJECTIVE: Visceral artery chimneys have been employed as an adjunct to endovascular aneurysm repair (EVAR) to treat short-neck infrarenal and juxtarenal aortic aneurysms for more than two decades. With the widespread introduction of fenestrated endovascular aneurysm repair by the Food and Drug Administration-approved Zenith Fenestrated endograft (ZFEN; Cook Medical, Bloomington, Ind) to the United States in 2012, clinicians gained the ability to apply the chimney technique to these custom devices for difficult anatomy...
June 18, 2018: Journal of Vascular Surgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"