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JOURNAL ARTICLE
Savannah M Decker, Petr Bruza, Rongxiao Zhang, Benjamin B Williams, Lesley A Jarvis, Brian W Pogue, David J Gladstone
BACKGROUND: While careful planning and pre-treatment checks are performed to ensure patient safety during external beam radiation therapy (EBRT), inevitable daily variations mean that in vivo dosimetry (IVD) is the only way to attain the true delivered dose. Several countries outside the US require daily IVD for quality assurance. However, elsewhere, the manual labor and time considerations of traditional in vivo dosimeters may be preventing frequent use of IVD in the clinic. PURPOSE: This study expands upon previous research using plastic scintillator discs for optical dosimetry for electron therapy treatments...
April 10, 2024: Medical Physics
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JOURNAL ARTICLE
Sankar Arumugam, Mark Sidhom
PURPOSE: To assess the robustness of the dose delivered to the clinical target volume (CTV) between planning target volume (PTV)-based and robust optimization planning approaches in localized prostate cancer radiation therapy. METHODS AND MATERIALS: Retrospective data of 20 patients with prostate cancer, including radiation therapy and real-time prostate position, were analyzed. Two sets of volumetric modulated arc therapy plans were generated per patient: PTV-based and robust optimization...
May 2024: Advances in Radiation Oncology
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JOURNAL ARTICLE
Rahul Pemmaraju, Gayoung Kim, Lina Mekki, Daniel Y Song, Junghoon Lee
PURPOSE: Segmentation of the prostate and surrounding organs at risk from computed tomography is required for radiation therapy treatment planning. We propose an automatic two-step deep learning-based segmentation pipeline that consists of an initial multi-organ segmentation network for organ localization followed by organ-specific fine segmentation. APPROACH: Initial segmentation of all target organs is performed using a hybrid convolutional-transformer model, axial cross-attention UNet...
March 2024: Journal of Medical Imaging
#24
JOURNAL ARTICLE
Arash O Naghavi, J M Bryant, Youngchul Kim, Joseph Weygand, Gage Redler, Austin J Sim, Justin Miller, Kaitlyn Coucoules, Lauren Taylor Michael, Warren E Gloria, George Yang, Stephen A Rosenberg, Kamran Ahmed, Marilyn M Bui, Evita B Henderson-Jackson, Andrew Lee, Caitlin D Lee, Ricardo J Gonzalez, Vladimir Feygelman, Steven A Eschrich, Jacob G Scott, Javier Torres-Roca, Kujtim Latifi, Nainesh Parikh, James Costello
BACKGROUND: Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR ≥ 95%) from RT is associated with improved patient outcome. Genomic adjusted radiation dose (GARD), a radiation-specific metric that quantifies the expected RT treatment effect as a function of tumor dose and genomics, proposed that STS is significantly underdosed...
April 9, 2024: BMC Cancer
#25
JOURNAL ARTICLE
Sushma Agrawal, Anshika Gupta, Vishwas Kapoor, Rahul Rahul, Ashish Singh, Prabhakar Mishra, Rajan Saxena
PURPOSE: Gall bladder cancers (GBC) usually presents in advanced stage. First-line chemotherapy (CT) is the standard of care, and there is no other option for responders than to wait for disease progression. We conducted a randomized study of consolidation chemoradiation (CTRT) versus observation in responders to first line CT (NCT05493956), which showed an improvement in overall survival by 6 months and therefore is practice changing. We are reporting the toxicity and factors predicting toxicity due to CTRT so that it informs appropriate patient selection...
May 2024: Advances in Radiation Oncology
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JOURNAL ARTICLE
Qateeb Khan, Breann Bowar, Bryn Myers, Fatima Kenjar, James D Byrne, Jordan Gainey
PURPOSE: An effective didactic curriculum is a cornerstone for a successful residency program, as it is the basis upon which residents acquire the necessary knowledge and perspective to provide high-quality, evidence-based care. Here we describe our success in creating a standardized curriculum in clinical radiation oncology - one that was well-received and led to significantly improved performance on the national in-service examination. METHODS AND MATERIALS: One-hundred and fifty topics were outlined in accordance with the American Board of Radiology; to accommodate this breadth of material, didactic frequency was increased from biweekly to daily...
May 2024: Advances in Radiation Oncology
#27
JOURNAL ARTICLE
Louis Cappelli, Mehak Khan, Sudheshna Vemula, Christina Hum, Haisong Liu, Yan Yu, Yingxuan Chen, Yechi Zhang, Muhammad Sharif, Wenyin Shi
INTRODUCTION: Radiation treatment has replaced enucleation as an organ-preservation treatment for patients with uveal melanoma (UM). We developed a novel non-invasive, frameless LINAC based solution for fractionated stereotactic radiosurgery (fSRS) treatment. METHODS: We designed and constructed the a stereotactic ocular localization box that can be attached and indexed to a stereotactic LINAC tabletop. It contains adjustable LED lights as a gaze focus point and CCD camera for monitoring of the patient's eye position...
2024: Frontiers in Oncology
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JOURNAL ARTICLE
Elena Riggenbach, Manuel Waser, Simon A Mueller, Daniel M Aebersold, Roland Giger, Olgun Elicin
BACKGROUND AND PURPOSE: The volume treated with postoperative radiation therapy (PORT) in patients with oral cavity squamous cell carcinoma (OCSCC) is a mediator of toxicity affecting quality of life. Current guidelines only allow for very limited reduction of PORT volumes. This study investigated the safety and efficacy of de-intensified PORT for patients with OCSCC by refined compartmentalization of the treatment volume. MATERIALS AND METHODS: This retrospective cohort study identified 103 OCSCC patients treated surgically from 2014 to 2019 with a loco-regional risk profile qualifying for PORT according to guidelines...
2024: Frontiers in Oncology
#29
JOURNAL ARTICLE
Raquel Dávila Fajardo, Giovanni Scarzello, Mark N Gaze, Tom Boterberg, Alison Cameron, Joerg Fuchs, Florent Guérin, Peter Hoskin, Matthew J Krasin, Petra Kroon, Henriette Magelssen, Claes Mercke, Johannes H M Merks, Frank Paulsen, Pascal Pommier, Monica Ramos, Helen Rees, Tim Rogers, Maximilian Schmid, Guido Seitz, Olga Slater, Naima Smeulders, Jakob Stenman, Sheila Terwisscha, Cyrus Chargari, Henry C Mandeville
BACKGROUND AND PURPOSE: The purpose of this study was to address the lack of published data on the use of brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point to develop consensus guidelines. MATERIALS AND METHODS: An international expert panel on the treatment of pediatric rhabdomyosarcoma comprising 24 (pediatric) radiation oncologists, brachytherapists and pediatric surgeons met for a Brachytherapy Workshop hosted by the European paediatric Soft tissue Sarcoma Study Group (EpSSG)...
April 6, 2024: Radiotherapy and Oncology
#30
Elisha Myers, Matthew Uhde
Merkel cell carcinoma (MCC) is a cutaneous neoplasm that is challenging to diagnose secondary to its rarity. We report a case involving a 76-year-old Caucasian female with a seemingly benign skin nodule on her right forearm. Histopathological analysis revealed characteristics of MCC, including uniform round cells with minimal cytoplasm and fine granular chromatin. Immunohistochemical staining confirmed insulinoma-associated protein 1 (INSM1) positivity, a marker with high sensitivity and specificity in localized MCC diagnosis...
March 2024: Curēus
#31
JOURNAL ARTICLE
C A Fink, J Ristau, C Buchele, S Klüter, J Liermann, P Hoegen-Saßmannshausen, E Sandrini, A Lentz-Hommertgen, L Baumann, N Andratschke, M Baumgartl, M Li, M Reiner, S Corradini, J Hörner-Rieber, D Bonekamp, H-P Schlemmer, C Belka, M Guckenberger, J Debus, S A Koerber
BACKGROUND: Due to superior image quality and daily adaptive planning, MR-guided stereotactic body radiation therapy (MRgSBRT) has the potential to further widen the therapeutic window in radiotherapy of localized prostate cancer. This study reports on acute toxicity rates and patient-reported outcomes after MR-guided adaptive ultrahypofractionated radiotherapy for localized prostate cancer within the prospective, multicenter phase II SMILE trial. MATERIALS AND METHODS: A total of 69 patients with localized prostate cancer underwent MRgSBRT with daily online plan adaptation...
May 2024: Clinical and Translational Radiation Oncology
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REVIEW
Martina Ferioli, Federica Medici, Ludovica Forlani, Savino Cilla, Bruno Fionda, Silvia Cammelli, Lidia Strigari, Luca Tagliaferri, Alessio G Morganti, Milly Buwenge
Brachytherapy (BRT) plays a pivotal role in the treatment of tumors, offering precise radiation therapy directly to the affected area. However, this technique demands extensive training and skills development, posing challenges for widespread adoption and ensuring patient safety. This narrative review explored the utilization of augmented reality (AR) in BRT, seeking to summarize existing evidence, discuss key findings, limitations, and quality of research as well as outline future research directions. The review revealed promising findings regarding the integration of AR in BRT...
February 2024: Journal of Contemporary Brachytherapy
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JOURNAL ARTICLE
Rasla Parween, Aruna R, Chendil V, Mahita Reddy, Ramyaa S, Varun Chandra, Yuvaraj U, Amrut S Kadam
PURPOSE: Brachytherapy plays a crucial role in the standard of care for locally advanced gynecological malignancies. In this report, we present the experience from a tertiary teaching hospital, which is a referral center for image-guided brachytherapy (IGBT) in the management of locally advanced gynecological malignancies. MATERIAL AND METHODS: This was a retrospective study of 130 patients referred to our hospital for IGBT after receiving initial external beam radiotherapy in their primary healthcare facilities, from January 2021 till January 2023...
February 2024: Journal of Contemporary Brachytherapy
#34
JOURNAL ARTICLE
Zhe Wu, Mujun Liu, Ya Pang, Lihua Deng, Yi Yang, Yi Wu
Purpose: Deep learning (DL) is widely used in dose prediction for radiation oncology, multiple DL techniques comparison is often lacking in the literature. To compare the performance of 4 state-of-the-art DL models in predicting the voxel-level dose distribution for cervical cancer volumetric modulated arc therapy (VMAT). Methods and Materials: A total of 261 patients' plans for cervical cancer were retrieved in this retrospective study. A three-channel feature map, consisting of a planning target volume (PTV) mask, organs at risk (OARs) mask, and CT image was fed into the three-dimensional (3D) U-Net and its 3 variants models...
2024: Technology in Cancer Research & Treatment
#35
JOURNAL ARTICLE
Sodai Tanaka, Taku Nakaji, Hideyuki Mizuno, Kota Mizushima, Ken Katagiri, Koki Kasamatsu, Takamitsu Masuda, Taku Inaniwa
At the National Institutes for Quantum Science and Technology (QST), a multi-ion therapy using helium, carbon, oxygen, and neon ions has been studied for charged particle therapy with more optimal biological effects. To make multi-ion therapy clinically feasible, a new treatment system was developed to realize the changes of the ion species in each irradiation using the Heavy Ion Medial Accelerator in Chiba (HIMAC). Since radiation therapy is safety-critical, it is necessary to construct a safety system that includes multiple safety barriers in the new treatment system for multi-ion therapy and to perform a safety analysis for the prevention of serious accidents...
2024: Japanese Journal of Medical Physics
#36
JOURNAL ARTICLE
Zhuo Chen, Zhuoling Zou, Min Qian, Qin Xu, Guojuan Xue, Juan Yang, Tinglan Luo, Lianjie Hu, Bin Wang
INTRODUCTION: This study aimed to investigate the safety and efficacy of neoadjuvant chemoradiotherapy combined with immune checkpoint inhibitors (ICIs) in patients with locally advanced rectal cancer (LARC). Patients diagnosed with LARC and treated with programmed cell death protein-1 (PD-1) inhibitors were recruited. METHODS: Four different treatment strategies were employed in this study: plan A [long-course radiotherapy + PD-1 inhibitor/capecitabine + PD-1 inhibitor/XELOX+ total mesorectal excision (TME)], plan B (long-course radiotherapy + capecitabine + PD-1 inhibitor/XELOX + TME), plan C (short-course radiotherapy + PD-1 inhibitor/XELOX + TME), and plan D (PD-1 inhibitor/XELOX + short-course radiotherapy + TME)...
April 6, 2024: Translational Oncology
#37
JOURNAL ARTICLE
Ibrahima Diallo, Rodrigue S Allodji, Cristina Veres, Stéphanie Bolle, Damien Llanas, Safaa Ezzouhri, Wael Zrafi, Ghazi Debiche, Vincent Souchard, Romain Fauchery, Nadia Haddy, Neige Journy, Charlotte Demoor-Goldschmidt, David L Winter, Lars Hjorth, Thomas Wiebe, Riccardo Haupt, Charlotte Robert, Leontien Kremer, Edit Bardi, Carlotta Sacerdote, Monica Terenziani, Claudia E Kuehni, Christina Schindera, Roderick Skinner, Jeanette Falck Winther, Päivi Lähteenmäki, Julianne Byrn, Zsuzsanna Jakab, Elisabeth Cardis, Elisa Pasqual, Soile Tapio, Sarah Baatout, Mike Atkinson, Mohammed Abderrafi Benotmane, Elaine Sugden, Lorna Zadravec Zaletel, Cecile Ronckers, Raoul C Reulen, Mike M Hawkins, Florent de Vathaire
BACKGROUND: Childhood cancer survivors are at high risk of long-term iatrogenic events, in particular those treated with radiotherapy. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. PURPOSE: We aimed to set up a standardised organ dose table in order to help former patients and clinician in charge of long term follow-up clinics...
April 4, 2024: International Journal of Radiation Oncology, Biology, Physics
#38
JOURNAL ARTICLE
David Kästner, Anja Braune, Claudia Brogsitter, Robert Freudenberg, Jörg Kotzerke, Enrico Michler
BACKGROUND: The administration of a 166 Ho scout dose is available as an alternative to 99m Tc particles for pre-treatment imaging in Selective Internal Radiation Therapy (SIRT). It has been reported that the 166 Ho scout dose may be more accurate for the prediction of microsphere distribution and the associated therapy planning. The aim of the current study is to compare the scintigraphic imaging characteristics of both isotopes, considering the objectives of the pre-treatment imaging using clinically geared phantoms...
April 6, 2024: EJNMMI Physics
#39
JOURNAL ARTICLE
Kylie H Kang, Alex T Price, Francisco J Reynoso, Eric Laugeman, Eric D Morris, Pamela P Samson, Jiayi Huang, Shahed N Badiyan, Hyun Kim, Randall J Brenneman, Christopher D Abraham, Nels C Knutson, Lauren E Henke
PURPOSE: We aimed to demonstrate the clinical feasibility and safety of simulation-free hippocampal avoidance whole brain radiation therapy (HA-WBRT) in a pilot study (NCTXXX). MATERIALS/METHODS: Ten HA-WBRT candidates were enrolled for treatment on a commercially available computed tomography (CT)-guided linear accelerator with online adaptive capabilities. Planning structures were contoured on patient-specific diagnostic MRIs, which were registered to a CT of similar head shape, obtained from an atlas-based database (AB-CT)...
April 3, 2024: International Journal of Radiation Oncology, Biology, Physics
#40
JOURNAL ARTICLE
Ruiqi Li, Tingliang Zhuang, Steven Montalvo, Kai Wang, David Parsons, Yuanyuan Zhang, Puneeth Iyengar, Jing Wang, Andrew Godley, Bin Cai, Mu-Han Lin, Kenneth Westover
PURPOSE: Real time adaptation of thoracic radiation plans is compelling because offline adaptive experiences show that tumor volumes and lung anatomy can change during therapy. We present and analyze a novel adaptive-on-demand (AOD) workflow combining online adaptive radiotherapy (ART) on the ETHOS system with image-guided radiotherapy (IGRT) delivery on a Halcyon unit for conventional fractionated radiotherapy of locally advanced lung cancer (LALC). METHOD: We analyzed 26 LALC patients treated with the AOD workflow, adapting weekly...
April 3, 2024: Practical Radiation Oncology
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