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Radiation therapy planning

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https://www.readbyqxmd.com/read/29037024/treatment-outcome-and-risk-analysis-for-cataract-after-radiotherapy-of-localized-ocular-adnexal-mucosa-associated-lymphoid-tissue-malt-lymphoma
#1
Hee Hyun Park, Sea-Won Lee, Soo Yoon Sung, Byung Ock Choi
PURPOSE: We retrospectively reviewed the results of radiotherapy for localized ocular adnexal MALT lymphoma (OAML) to investigate the risk factors of cataract. METHODS: Sixty-seven patients with stage IE OAML treated with radiotherapy at Seoul St. Mary's Hospital from 2001 to 2016 were included. Median treatment dose was 30 Gy. Lens protection was done in 52 (76%) patients. Radiation therapy (RT) extent was as follows: superficial (82.1%), tumor mass (4.5%), and entire orbital socket (13...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29031916/image-guided-adaptive-external-beam-radiation-therapy-for-cervix-cancer-evaluation-of-a-clinically-implemented-plan-of-the-day-technique
#2
Martin Buschmann, Katarina Majercakova, Alina Sturdza, Stephanie Smet, Dina Najjari, Michaela Daniel, Richard Pötter, Dietmar Georg, Yvette Seppenwoolde
BACKGROUND: Radiotherapy for cervix cancer is challenging in patients exhibiting large daily changes in the pelvic anatomy, therefore adaptive treatments (ART) have been proposed. The aim of this study was the clinical implementation and subsequent evaluation of plan-of-the-day (POTD)-ART for cervix cancer in supine positioning. The described workflow was based on standard commercial equipment and current quality assurance (QA) methods. MATERIALS AND METHODS: A POTD strategy, which employs a VMAT plan library consisting of an empty bladder plan, a full bladder plan and a motion robust backup plan, was developed...
October 11, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29031611/dose-to-mass-for-evaluation-and-optimization-of-lung-cancer-radiation-therapy
#3
William Tyler Watkins, Joseph A Moore, Geoffrey D Hugo, Jeffrey V Siebers
PURPOSE: To evaluate potential organ at risk dose-sparing by using dose-mass-histogram (DMH) objective functions compared with dose-volume-histogram (DVH) objective functions. METHODS: Treatment plans were retrospectively optimized for 10 locally advanced non-small cell lung cancer patients based on DVH and DMH objectives. DMH-objectives were the same as DVH objectives, but with mass replacing volume. Plans were normalized to dose to 95% of the PTV volume (PTV-D95v) or mass (PTV-D95m)...
October 11, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29030912/the-development-and-implementation-of-a-performance-appraisal-framework-for-radiation-therapists-in-planning-and-simulation
#4
Jillian Becker, Pete Bridge, Elizabeth Brown, Janet Ferrari-Anderson, Ryan Lusk
It is a challenge for radiation therapists (RTs) to keep pace with changing planning technology and techniques while maintaining appropriate skills levels. The ability of individual RTs to meet the demands of this constantly changing practice can only be assured through establishing clearly defined standards for practice and a systematic process for providing feedback on performance. Investigation into existing models for performance appraisal produced minimal results so a radiation therapy-specific framework was developed...
October 14, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29030753/successful-implementation-of-virtual-environment-for-radiotherapy-training-vert-in-medical-physics-education-the-university-of-sydney-s-initial-experience-and-recommendations
#5
Yobelli A Jimenez, Christian Rønn Hansen, Prabhjot Juneja, David I Thwaites
This report outlines the University of Sydney's initial experience with the Virtual Environment for Radiotherapy Training (VERT) system in the Master of Medical Physics program. VERT is a commercially available system, simulating linear accelerators, patient computed tomography (CT) sets, plans and treatment delivery. It was purpose built for radiation therapy (RT) education and offers learners the opportunity to gain knowledge and skills within an interactive, risk-free environment. The integration of VERT into the RT physics module of the Master of Medical Physics program was intended to enhance student knowledge and skills relevant to the curriculum's learning objectives, and to alleviate some of the burden associated with student access to clinical equipment...
October 13, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29029890/radiation-therapy-deficiencies-identified-during-on-site-dosimetry-visits-by-the-imaging-and-radiation-oncology-core-houston-quality-assurance-center
#6
Stephen F Kry, Lainy Dromgoole, Paola Alvarez, Jessica Leif, Andrea Molineu, Paige Taylor, David S Followill
PURPOSE: To review the dosimetric, mechanical, and programmatic deficiencies most frequently observed during on-site visits of radiation therapy facilities by the Imaging and Radiation Oncology Core Quality Assurance Center in Houston (IROC Houston). METHODS AND MATERIALS: The findings of IROC Houston between 2000 and 2014, including 409 institutions and 1020 linear accelerators (linacs), were compiled. On-site evaluations by IROC Houston include verification of absolute calibration (tolerance of ±3%), relative dosimetric review (tolerances of ±2% between treatment planning system [TPS] calculation and measurement), mechanical evaluation (including multileaf collimator and kilovoltage-megavoltage isocenter evaluation against Task Group [TG]-142 tolerances), and general programmatic review (including institutional quality assurance program vs TG-40 and TG-142)...
August 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29024297/reducing-dose-to-the-lungs-through-loosing-target-dose-homogeneity-requirement-for-radiotherapy-of-non-small-cell-lung-cancer
#7
Junjie Miao, Hui Yan, Yuan Tian, Pan Ma, Zhiqiang Liu, Minghui Li, Wenting Ren, Jiayun Chen, Ye Zhang, Jianrong Dai
It is important to minimize lung dose during intensity-modulated radiation therapy (IMRT) of nonsmall cell lung cancer (NSCLC). In this study, an approach was proposed to reduce lung dose by relaxing the constraint of target dose homogeneity during treatment planning of IMRT. Ten NSCLC patients with lung tumor on the right side were selected. The total dose for planning target volume (PTV) was 60 Gy (2 Gy/fraction). For each patient, two IMRT plans with six beams were created in Pinnacle treatment planning system...
October 11, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29023771/visibility-of-fiducial-markers-used-for-image-guided-radiation-therapy-on-optical-coherence-tomography-for-registration-with-ct-an-esophageal-phantom-study
#8
Pouya Jelvehgaran, Tanja Alderliesten, Jelmer J A Weda, Martijn de Bruin, Dirk J Faber, Maarten C C M Hulshof, Ton G van Leeuwen, Marcel van Herk, Johannes F de Boer
PURPOSE: Optical coherence tomography (OCT) is of interest to visualize microscopic esophageal tumor extensions to improve tumor delineation for radiation therapy (RT) planning. Fiducial marker placement is a common method to ensure target localization during planning and treatment. Visualization of these fiducial markers on OCT permits integrating OCT and computed tomography (CT) images used for RT planning via image registration. We studied the visibility of 13 (8 types) commercially available solid and liquid fiducial markers in OCT images at different depths using dedicated esophageal phantoms and evaluated marker placement depth in clinical practice...
October 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/29023527/dose-escalated-radiotherapy-for-unresectable-or-locally-recurrent-pancreatic-cancer-dose-volume-analysis-toxicity-and-outcome-of-28-consecutive-patients
#9
Sebastian Zschaeck, Bibiana Blümke, Peter Wust, David Kaul, Marcus Bahra, Hanno Riess, Fritz Klein, Marianne Sinn, Uwe Pelzer, Volker Budach, Pirus Ghadjar
PURPOSE: The role of radiotherapy for unresectable pancreatic cancer is controversial. A benefit of additional radiotherapy is supported by some observations. A dose-effect relationship was recently found by dose escalation employing image guided and intensity modulated radiotherapy. METHODS: We retrospectively evaluated 28 consecutive patients, all with history of extensive prior therapies for unresectable locally advanced/ recurrent pancreatic cancer (LAPC/LRPC)...
2017: PloS One
https://www.readbyqxmd.com/read/29020868/extended-pelvic-lymph-node-dissection-and-radiotherapy-with-curative-intent-in-high-risk-lymph-node-positive-prostate-cancer-a-possible-curative-strategy
#10
Bashar Al-Amiri, Fredrik Lundin, Mauritz Waldén
OBJECTIVE: This study evaluated the outcome with a treatment strategy for high-risk prostate cancer (PCa) using extended pelvic lymph-node dissection (eLND) followed by external beam radiation therapy (EBRT) in lymph-node-positive (LNpos) and lymph-node-negative (LNneg) cases compared with the strategy with limited pelvic lymph-node dissection (lLND) and only giving EBRT to LNneg cases. MATERIALS AND METHODS: From 2000 to 2006, 124 men with high-risk PCa underwent lLND and initiated androgen deprivation therapy (ADT) before planned EBRT...
October 12, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29019894/randomized-controlled-trial-of-late-course-concurrent-versus-sequential-chemoradiotherapy-after-mastectomy-and-axillary-surgery-in-locally-advanced-breast-cancer
#11
Ying Lu, Haixin Huang, Hui Yang, Dagui Chen
BACKGROUND: Concurrent chemoradiotherapy could increase the local control rate in patients with high recurrence risk after breast-conserving surgery, but the effect of concurrent chemoradiotherapy after mastectomy and axillary dissection is not clear. The aim of the study was to compare the effects of late-course concurrent chemoradiotherapy (CCRT) versus sequential therapy (SCRT) after mastectomy and axillary surgery in locally advanced breast cancer. METHODS: This was a randomized controlled trial of 155 patients with stage pT3-4p N1-3c M0 or pAnyT pN2-3c M0 breast cancer undergoing 5-fluorouracil+epirubicin+cyclophosphamide followed by docetaxel (FEC-D) chemotherapy after mastectomy and axillary dissection...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29017157/impact-of-the-number-of-metastatic-tumors-treated-by-stereotactic-radiosurgery-on-the-dose-to-normal-brain-implications-for-brain-protection
#12
Charlotte Rivers, Marissa Tranquilli, Shefalika Prasad, Evan Winograd, Robert J Plunkett, Robert A Fenstermaker, Andrew J Fabiano, Matthew B Podgorsak, Dheerendra Prasad
PURPOSE/OBJECTIVES: The purpose of this study was to evaluate the effect of the number of brain lesions for which stereotactic radiosurgery (SRS) was performed on the dose volume relationships in normal brain. MATERIALS AND METHODS: Brain tissue was segmented using the patient's pre-SRS MRI. For each plan, the following data points were recorded: total brain volume, number of lesions treated, volume of brain receiving 8 Gy (V8), V10, V12, and V15. RESULTS: A total of 225 Gamma Knife® treatments were included in this retrospective analysis...
October 11, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28994665/combining-deep-learning-with-anatomy-analysis-for-segmentation-of-portal-vein-for-liver-sbrt-planning
#13
Bulat Ibragimov, Diego Toesca, Daniel Chang, Albert Koong, Lei Xing
Automated segmentation of portal vein (PV) for liver radiotherapy planning is a challenging task due to potentially low vasculature contrast, complex PV anatomy and image artifacts originated from fiducial markers and vasculature stents. In this paper, we propose a novel framework for automated PV segmentation from computed tomography (CT) images. We apply convolutional neural networks (CNN) to learn consistent appearance patterns of PV using a training set of CT images with reference annotations and then enhance PV in previously unseen CT images...
October 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28994459/neural-network-dose-models-for-knowledge-based-planning-in-pancreatic-sbrt
#14
Warren G Campbell, Moyed Miften, Lindsey Olsen, Priscilla Stumpf, Tracey Schefter, Karyn A Goodman, Bernard L Jones
PURPOSE: Stereotactic body radiation therapy (SBRT) for pancreatic cancer requires a skillful approach to deliver ablative doses to the tumor while limiting dose to the highly sensitive duodenum, stomach, and small bowel. Here, we develop knowledge-based artificial neural network dose models (ANN-DMs) to predict dose distributions that would be approved by experienced physicians. METHODS: Arc-based SBRT treatment plans for 43 pancreatic cancer patients were planned, delivering 30-33 Gy in five fractions...
October 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28993138/the-impact-of-imaging-modality-ct-vs-mri-and-patient-position-supine-vs-prone-on-tangential-whole-breast-radiation-therapy-planning
#15
Kylie Dundas, Elise M Pogson, Vikneswary Batumalai, Geoff P Delaney, Miriam M Boxer, Mei Ling Yap, Verity Ahern, Christine Chan, Steven David, Marion Dimigen, Jennifer A Harvey, Eng-Siew Koh, Karen Lim, George Papadatos, Elizabeth Lazarus, Joseph Descellar, Peter Metcalfe, Lois Holloway
PURPOSE: The purpose of this study was to evaluate the impact of magnetic resonance imaging (MRI) versus computed tomography (CT)-derived planning target volumes (PTVs), in both supine and prone positions, for whole breast (WB) radiation therapy. METHODS AND MATERIALS: Four WB radiation therapy plans were generated for 28 patients in which PTVs were generated based on CT or MRI data alone in both supine and prone positions. A 6-MV tangential intensity modulated radiation therapy technique was used, with plans designated as ideal, acceptable, or noncompliant...
July 14, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28989000/use-of-18-f-fdg-pet-ct-imaging-to-determine-internal-mammary-lymph-node-location-for-radiation-therapy-treatment-planning-in-breast-cancer-patients
#16
Tima Davidson, Merav Ben-David, Shira Galper, Tess Haskin, Megan Howes, Roland Scaife, Nayroz Kanana, Uri Amit, Noam Weizman, Bar Chikman, Elinor Goshen, Simona Ben-Haim, Zvi Symon, Jeffrey Goldstein
PURPOSE: Adjuvant internal mammary lymph node (IMN) radiation is often delivered with 2-dimensional techniques that use anatomic landmarks and predetermined depths for field placement and dose specification. In contrast, 3-dimensional planning uses the internal mammary vessels (IMVs) to localize the IMNs for planning. Our purpose was to determine if localization of the involved IMN (i-IMN) by (18)F-labeled fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG PET-CT) offers opportunities to improve treatment...
November 5, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28988893/radiation-therapy-of-synchronous-bilateral-breast-carcinoma-sbbc-using-multiple-techniques
#17
Sung Jin Kim, Mi Jo Lee, Seon Min Youn
The purpose of this study was to establish intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) treatment plans for synchronous bilateral breast cancer (SBBC) and to compare those plans with the previous treatment plans using 3D conformal radiation therapy (3DCRT). The differences among the treatments were also statistically compared regarding dosimetry distribution and treatment efficiency. The research was conducted with 10 SBBC patients. The study established IMRT (12 fields with a single isocenter) and VMAT (2 partial arcs with a single isocenter) treatment plans for SBBC patients and then compared those plans with 3DCRT (8 fields with multiple isocenters)...
October 5, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28988661/american-college-of-radiology-american-brachytherapy-society-practice-parameter-for-electronically-generated-low-energy-radiation-sources
#18
Phillip M Devlin, Laurie E Gaspar, Ivan Buzurovic, D Jeffrey Demanes, Michael E Kasper, Subir Nag, Zoubir Ouhib, Joshua H Petit, Seth A Rosenthal, William Small, Paul E Wallner, Alan C Hartford
BACKGROUND: This collaborative practice parameter technical standard has been created between the American College of Radiology and American Brachytherapy Society to guide the usage of electronically generated low energy radiation sources (ELSs). It refers to the use of electronic X-ray sources with peak voltages up to 120 kVp to deliver therapeutic radiation therapy. MAIN FINDINGS: The parameter provides a guideline for utilizing ELS, including patient selection and consent, treatment planning, and delivery processes...
October 5, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28984752/intensity-modulated-radiation-therapy-for-patients-with-1-to-3-brain-metastases-in-recursive-partitioning-analysis-class-3
#19
Jia Yang, Wenming Zhan, Haibo Zhang, Tao Song, Yongshi Jia, Hongen Xu, Baihua Lin, Shiliang Lv, Xiaodong Liang
The prognosis is extremely poor for patients with brain metastases in recursive partitioning analysis (RPA) class 3. It is not clear whether dose elevation for brain lesions in addition to whole-brain radiotherapy could improve survival for those patients. This study aimed to assess the efficacy and safety of dose elevation with intensity-modulated radiation therapy (IMRT) for patients with 1 to 3 brain metastases in RPA class 3.From January 2013 to December 2015, 24 patients with 1 to 3 brain metastases in RPA class 3 were included in this study...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28982897/interfractional-rectal-displacement-requiring-repeated-precaution-did-not-correlate-to-biochemical-control-and-rectal-toxicity-in-patients-with-prostate-cancer-treated-with-image-guided-intensity-modulated-radiation-therapy
#20
Kazuki Iwama, Hideya Yamazaki, Daisuke Shimizu, Gen Suzuki, Satoaki Nakamura, Naomi Sasaki, Tadashi Takeneka, Haruumi Okabe, Tatsuyuki Nishikawa, Ken Yoshida
AIM: To investigate the correlation between frequency of action level of interfractional rectal displacement requiring repeated precaution in patients with prostate cancer and late toxicity from image-guided intensity-modulated radiation therapy (IG-IMRT) using helical tomotherapy. PATIENTS AND METHODS: We examined 264 patients who underwent IG-IMRT during 2007-2011. Megavoltage computed tomographic (MVCT) images were acquired before radiation therapy and was examined with soft-tissue matching by comparing treatment planning images within 9,345 fractions...
October 2017: Anticancer Research
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