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https://www.readbyqxmd.com/read/29240558/a-modified-microdosimetric-kinetic-model-for-relative-biological-effectiveness-calculation
#1
Yizheng Chen, Junli Li, Chunyan Li, Rui Qiu, Zhen Wu
In the heavy ion therapy, not only the distribution of physical absorbed dose, but also the relative biological effectiveness (RBE) weighted dose needs to be taken into account. The microdosimetric kinetic model (MKM) can predict the RBE value of heavy ions with saturation-corrected dose-mean specific energy, which has been used in clinical treatment planning at the National Institute of Radiological Sciences. In the theoretical assumption of the MKM, the yield of the primary lesion is independent of the radiation quality, while the experimental data shows that DNA double strand break (DSB) yield, considered as the main primary lesion, depends on the LET of the particle...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29237970/a-dosimetric-comparison-between-three-dimensional-conformal-radiation-therapy-and-intensity-modulated-radiation-therapy-in-the-treatment-of-posterior-fossa-boost-in-medulloblastoma
#2
Meenu Gupta, Ravi Kant, Vipul Nautiyal, Jyoti Bisht, Shalindra Raghuvanshi, Manju Saini, B P Kalra, Mushtaq Ahmad
AIMS: To compare three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) in posterior fossa (PF) boost in children with medulloblastoma (MB); dosimetrically evaluating and comparing both techniques with regard to target coverage and doses to organs at risk. SETTINGS AND DESIGN: Structured. SUBJECTS AND METHODS: Seven previously irradiated patients of MB were retrieved and re-planned with both 3DCRT and IMRT techniques...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29236642/noninvasive-cardiac-radiation-for-ablation-of-ventricular-tachycardia
#3
Phillip S Cuculich, Matthew R Schill, Rojano Kashani, Sasa Mutic, Adam Lang, Daniel Cooper, Mitchell Faddis, Marye Gleva, Amit Noheria, Timothy W Smith, Dennis Hallahan, Yoram Rudy, Clifford G Robinson
BACKGROUND: Recent advances have enabled noninvasive mapping of cardiac arrhythmias with electrocardiographic imaging and noninvasive delivery of precise ablative radiation with stereotactic body radiation therapy (SBRT). We combined these techniques to perform catheter-free, electrophysiology-guided, noninvasive cardiac radioablation for ventricular tachycardia. METHODS: We targeted arrhythmogenic scar regions by combining anatomical imaging with noninvasive electrocardiographic imaging during ventricular tachycardia that was induced by means of an implantable cardioverter-defibrillator (ICD)...
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29234845/eanm-guideline-for-radionuclide-therapy-with-radium-223-of-metastatic-castration-resistant-prostate-cancer
#4
Thorsten D Poeppel, Daria Handkiewicz-Junak, Michael Andreeff, Alexander Becherer, Andreas Bockisch, Eva Fricke, Lilli Geworski, Alexander Heinzel, Bernd J Krause, Thomas Krause, Markus Mitterhauser, Wilfried Sonnenschein, Lisa Bodei, Roberto C Delgado-Bolton, Michael Gabriel
Radium Ra-223 dichloride (radium-223, Xofigo®) is a targeted alpha therapy approved for the treatment of castration-resistant prostate cancer (CRPC) with symptomatic bone metastases and no known visceral metastatic disease. Radium-223 is the first targeted alpha therapy in this indication providing a new treatment option, with evidence of a significant survival benefit, both in overall survival and in the time to the first symptomatic skeletal-related event. The skeleton is the most common metastatic site in patients with advanced prostate cancer...
December 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29233523/stereotactic-body-radiation-therapy-for-stage-i-non-small-cell-lung-cancer-the-importance-of-treatment-planning-algorithm-and-evaluation-of-a-tumor-control-probability-model
#5
Nitin Ohri, Wolfgang Tomé, Shalom Kalnicki, Madhur Garg
BACKGROUND: Stereotactic body radiation therapy (SBRT) is increasingly used to treat early-stage non-small cell lung cancer (NSCLC). A previous report introduced the term size-adjusted biologically effective dose (sBED), which accounts for tumor diameter and biologically effective dose (BED) and may be used to predict the likelihood of local control following SBRT. Here we seek to replicate those findings using a separate dataset. METHODS AND MATERIALS: We queried the RSSearch Patient Registry for patients treated with SBRT for stage I NSCLC...
October 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29233522/subcutaneous-implant-based-breast-reconstruction-a-modern-challenge-in-postmastectomy-radiation-planning
#6
Melissa P Mitchell, Jamie Wagner, James Butterworth
PURPOSE: A growing trend in breast reconstruction has been placement of tissue expanders in the pre pectoral space. This is a change from the practice of placement under the pectoralis major with or without an acellular dermal matrix (ADM) sling. The move toward pre pectoral placement with an ADM wrap has the intent of decreasing post-operative pain and decreasing animation deformities. The cosmesis of pre pectoral reconstructions in the setting of post mastectomy radiation has also appeared improved in our early experience, when compared to submuscular reconstructions...
September 8, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29233486/cetuximab-combined-with-induction-oxaliplatin-and-capecitabine-followed-by-neoadjuvant-chemoradiation-for-locally-advanced-rectal-cancer-swog-0713
#7
Cynthia Gail Leichman, Shannon L McDonough, Stephen R Smalley, Kevin G Billingsley, Heinz-Josef Lenz, Matthew A Beldner, Aram F Hezel, Mario R Velasco, Katherine A Guthrie, Charles D Blanke, Howard S Hochster
BACKGROUND: Neoadjuvant chemoradiation (NCRT) is standard treatment for locally advanced rectal cancer. Pathologic complete response (pCR) has associated with improved survival. In modern phase III trials of NCRT, pCR ranges from 10% to 20%. Cetuximab improves response in KRAS (KRAS proto-oncogene) wild type (wt) metastatic colorectal cancer. S0713 was designed to assess improvement in pCR with additional use of cetuximab with induction chemotherapy and NCRT for locally advanced, KRAS-wt rectal cancer...
October 24, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29229377/dosimetric-effects-of-saline-versus-water-filled-balloon-applicators-for-iort-using-the-model-s700-electronic-brachytherapy-source
#8
Gage Redler, Alistair Templeton, Heming Zhen, Julius Turian, Damian Bernard, James C H Chu, Katherine L Griem, Yixiang Liao
PURPOSE: The Xoft Axxent Electronic Brachytherapy System (Xoft, Inc., San Jose, CA) is a viable option for intraoperative radiation therapy (IORT) treatment of early-stage breast cancer. The low-energy (50-kVp) X-ray source simplifies shielding and increases relative biological effectiveness but increases dose distribution sensitivity to medium composition. Treatment planning systems typically assume homogenous water for brachytherapy dose calculations, including precalculated atlas plans for Xoft IORT...
December 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29229344/cavernous-sinus-hemangioma-a-rare-vascular-tumor-of-the-cavernous-sinus
#9
Joshua Bakhsheshian, Gabriel Zada, Martin H Pham
Cavernous sinus hemangiomas (CSH) are rare vascular tumors, which are infrequently encountered in everyday neurosurgical practice. Attempted resection of this lesion without preoperative planning carries a high risk for significant blood loss and cranial neuropathies. Radiation treatments can provide an alternative and safe treatment modality for these lesions. Therefore, an increased awareness is warranted for their clinical suspicion. We reported on a patient that presented with visual deficits and a mass in the sellar, suprasellar and middle fossa regions...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29229326/quantifying-the-effect-of-3t-magnetic-resonance-imaging-residual-system-distortions-and-patient-induced-susceptibility-distortions-on-radiation-therapy-treatment-planning-for-prostate-cancer
#10
Mary Adjeiwaah, Mikael Bylund, Josef A Lundman, Camilla Thellenberg Karlsson, Joakim H Jonsson, Tufve Nyholm
PURPOSE: To investigate the effect of magnetic resonance system- and patient-induced susceptibility distortions from a 3T scanner on dose distributions for prostate cancers. METHODS AND MATERIALS: Combined displacement fields from the residual system and patient-induced susceptibility distortions were used to distort 17 prostate patient CT images. VMAT dose plans were initially optimized on distorted CT images and the plan parameters transferred to the original patient CT images to calculate a new dose distribution...
October 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29228751/comparisons-of-health-related-quality-of-life-among-surgery-and-radiotherapy-for-localized-prostate-cancer-a-systematic-review-and-meta-analysis
#11
Cheng Chen, Zhen Chen, Kun Wang, Linkun Hu, Renfang Xu, Xiaozhou He
The objective of this study is to compare health-related quality of life (QOL) outcomes between radical prostatectomy (RP) and external beam radiation therapy (EBRT) for localized prostate cancer. PubMed, EMBASE, the Cochrane Library and Web of Science (to July 2017) were searched. Pooled analysis of each domain-specific score was calculated in relevant studies, and its change with follow-up time was explored by sub-group analysis. A total of six studies containing 4423 patients were included. Men underwent RP was associated with worse urinary and sexual domain score than EBRT (standardized mean difference (SMD) = -0...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226038/pencil-beam-scanning-proton-therapy-for-rhabdomyosarcoma-of-the-biliary-tract
#12
Luke Pater, Brian Turpin, Anthony Mascia
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with 250-350 cases diagnosed annually in the United States. Biliary tract rhabdomyosarcoma is rare, representing <1% of the RMS cases. Due to its location, resection is clinically challenging, and functional complications exist and persist from biliary obstruction. The anatomical location of this tumor presents both opportunities and challenges for pencil beam scanning proton therapy. Proton therapy offers a dosimetric and clinical advantage by sparing the healthy liver, stomach, contra-lateral kidney and bowel...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29225692/recent-advances-in-radiation-oncology
#13
REVIEW
Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, Samantha Dicuonzo, Damaris Patricia Rojas, Federica Cattani, Anna Starzyńska, Delia Ciardo, Alessia Surgo, Maria Cristina Leonardi, Rosalinda Ricotti
Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29223302/modeling-the-target-dose-fall-off-in-imrt-and-vmat-planning-techniques-for-cervical-sbrt
#14
A Brito Delgado, D Cohen, T Y Eng, D N Stanley, Z Shi, M Charlton, A N Gutiérrez
There has been growing interest in the use of stereotactic body radiotherapy (SBRT) technique for the treatment of cervical cancer. The purpose of this study was to characterize dose distributions as well as model the target dose fall-off for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques using 6 and 10 MV photon beam energies. Fifteen (n = 15) patients with non-bulky cervical tumors were planned in Pinnacle3 with a Varian Novalis Tx (HD120 MLC) using 6 and 10 MV photons with the following techniques: (1) IMRT with 10 non-coplanar beams (2) dual, coplanar 358° VMAT arcs (4° spacing), and (3) triple, non-coplanar VMAT arcs...
December 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29222833/association-between-measures-of-treatment-quality-and-disease-progression-in-prostate-cancer-radiotherapy-an-exploratory-analysis-from-the-trog-03-04-radar-trial
#15
Marco Marcello, Martin A Ebert, Annette Haworth, Allison Steigler, Angel Kennedy, Max Bulsara, Rachel Kearvell, David J Joseph, James W Denham
INTRODUCTION: Quality assurance methods are incorporated into multicentre radiotherapy clinical trials for ensuring consistent application of trial protocol and quantifying treatment uncertainties. The study's purpose was to determine whether post-treatment disease progression is associated with measures of the quality of radiotherapy treatment. METHODS: The TROG 03.04 RADAR trial tested the impact of androgen deprivation on prostate cancer patients receiving dose-escalated external beam radiation therapy...
December 8, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29218271/magnetic-resonance-imaging-in-precision-radiation-therapy-for-lung-cancer
#16
REVIEW
Hannah Bainbridge, Ahmed Salem, Rob H N Tijssen, Michael Dubec, Andreas Wetscherek, Corinne Van Es, Jose Belderbos, Corinne Faivre-Finn, Fiona McDonald
Radiotherapy remains the cornerstone of curative treatment for inoperable locally advanced lung cancer, given concomitantly with platinum-based chemotherapy. With poor overall survival, research efforts continue to explore whether integration of advanced radiation techniques will assist safe treatment intensification with the potential for improving outcomes. One advance is the integration of magnetic resonance imaging (MRI) in the treatment pathway, providing anatomical and functional information with excellent soft tissue contrast without exposure of the patient to radiation...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29218270/anatomic-functional-and-molecular-imaging-in-lung-cancer-precision-radiation-therapy-treatment-response-assessment-and-radiation-therapy-personalization
#17
REVIEW
Michael MacManus, Sarah Everitt, Tanja Schimek-Jasch, X Allen Li, Ursula Nestle, Feng-Ming Spring Kong
This article reviews key imaging modalities for lung cancer patients treated with radiation therapy (RT) and considers their actual or potential contributions to critical decision-making. An international group of researchers with expertise in imaging in lung cancer patients treated with RT considered the relevant literature on modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET). These perspectives were coordinated to summarize the current status of imaging in lung cancer and flag developments with future implications...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29218269/blood-based-biomarkers-for-precision-medicine-in-lung-cancer-precision-radiation-therapy
#18
REVIEW
Dirk De Ruysscher, Jianyue Jin, Tim Lautenschlaeger, Jin-Xiong She, Zhongxing Liao, Feng-Ming Spring Kong
Both tumors and patients are complex and models that determine survival and toxicity of radiotherapy or any other treatment ideally must take into account this variability as well as its dynamic state. The genetic features of the tumor and the host, and increasingly also the epi-genetic and proteomic characteristics, are being unraveled. Multiple techniques, including histological examination, blood sampling, measurement of circulating tumor cells (CTCs), and functional and molecular imaging, can be used for this purpose...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29218264/role-of-pet-ct-for-precision-medicine-in-lung-cancer-perspective-of-the-society-of-nuclear-medicine-and-molecular-imaging
#19
Bennett S Greenspan
This article discusses the role of PET/CT in contributing to precision medicine in lung cancer, and provides the perspective of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) on this process. The mission and vision of SNMMI are listed, along with the guidance provided by SNMMI to promote best practice in precision medicine. Basic principles of PET/CT are presented. An overview of the use of PET/CT imaging in lung cancer is discussed. In lung cancer patients, PET/CT is vitally important for optimal patient management...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29217331/dosimetric-impact-of-translational-and-rotational-setup-errors-for-spine-stereotactic-body-radiotherapy-a-phantom-study
#20
Makoto Sasaki, Mitsuhiro Nakamura, Nobutaka Mukumoto, Manabu Nakata, Masahiro Hiraoka
This study aimed to investigate experimentally the effect of translational and rotational setup errors on 3-dimensional dose distributions by using the gamma index and dose volumetric indices for spine stereotactic body radiotherapy. Treatment plans were designed in accordance with the Radiation Therapy Oncology Group (RTOG) 0631 protocol. Measurements were taken using a Delta4 phantom (ScandiDos, Uppsala, Sweden). Setup errors were generated using the HexaMotion 6D moving platform (ScandiDos). Dose distributions in the presence of setup errors were evaluated, according to the γ passing rate with the 3% and 2 mm criteria (γ3%/2 mm) and dose volumetric indices (D90 for the target volume and D2 for the spinal cord), using the Delta4 device (ScandiDos)...
December 4, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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