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https://www.readbyqxmd.com/read/28822604/volumetric-modulated-arc-therapy-vmat-for-whole-brain-radiotherapy-not-only-for-hippocampal-sparing-but-also-for-reduction-of-dose-to-organs-at-risk
#1
Sumit Sood, Damodar Pokhrel, Christopher McClinton, Christopher Lominska, Rajeev Badkul, Hongyu Jiang, Fen Wang
A prospective clinical trial, Radiation Therapy Oncology Group (RTOG) 0933, has demonstrated that whole brain radiotherapy (WBRT) using conformal radiation delivery technique with hippocampal avoidance is associated with less memory complications. Further sparing of other organs at risk (OARs) including the scalp, ear canals, cochleae, and parotid glands could be associated with reductions in additional toxicities for patients treated with WBRT. We investigated the feasibility of WBRT using volumetric-modulated arc therapy (VMAT) to spare the hippocampi and the aforementioned OARs...
August 16, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28818321/influence-of-computed-tomography-contrast-agent-on-radiotherapy-dose-calculation-for-pancreatic-carcinoma-a-dosimetric-study-based-on-tomotherapy-and-volumetric-modulated-arc-therapy-techniques
#2
Feng Zhu, Weizhang Wu, Fuhai Zhu, Yong Wang, Yingjie Wang, Tingyi Xia
The main purpose of our investigation was to quantify the dosimetric influence of intravenous contrast agent for pancreatic cancer radiotherapy treatment. This study focused on complex modulated irradiation techniques of tomotherapy (TOMO) and volumetric-modulated arc therapy (VMAT) to investigate if novel conformal treatment methods could reduce the influence of contrast agent. In our study, patients with pancreatic cancer were enrolled to have 2 computed tomography (CT) scans in the same position without and with intravenous contrast agent for treatment planning...
August 14, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28816170/role-of-consolidative-radiation-therapy-after-autologous-hematopoietic-cell-transplantation-for-the-treatment-of-relapsed-or-refractory-hodgkin-lymphoma
#3
Christopher Wilke, Qing Cao, Kathryn E Dusenbery, Veronika Bachanova, Aleksandr Lazaryan, Chung K Lee, Jianling Yuan
PURPOSE: To evaluate the role of the addition of consolidative radiation therapy after high-dose chemotherapy and autologous hematopoietic cell transplantation (AHCT) for relapsed or refractory Hodgkin lymphoma (HL). METHODS AND MATERIALS: Medical records were reviewed from a total of 80 consecutive patients who underwent high-dose chemotherapy with AHCT treated under a single protocol at University of Minnesota between November 2005 and January 2014. Of these, 32 patients received radiation therapy after AHCT as planned consolidation...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28816167/variabilities-of-magnetic-resonance-imaging-computed-tomography-and-positron-emission-tomography-computed-tomography-based-tumor-and-lymph-node-delineations-for-lung-cancer-radiation-therapy-planning
#4
Kishor Karki, Siddharth Saraiya, Geoffrey D Hugo, Nitai Mukhopadhyay, Nuzhat Jan, Jessica Schuster, Matthew Schutzer, Lester Fahrner, Robert Groves, Kathryn M Olsen, John C Ford, Elisabeth Weiss
PURPOSE: To investigate interobserver delineation variability for gross tumor volumes of primary lung tumors and associated pathologic lymph nodes using magnetic resonance imaging (MRI), and to compare the results with computed tomography (CT) alone- and positron emission tomography (PET)-CT-based delineations. METHODS AND MATERIALS: Seven physicians delineated the tumor volumes of 10 patients for the following scenarios: (1) CT only, (2) PET-CT fusion images registered to CT ("clinical standard"), and (3) postcontrast T1-weighted MRI registered with diffusion-weighted MRI...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28816162/heart-dosimetry-is-correlated-with-risk-of-radiation-pneumonitis-after-lung-sparing-hemithoracic-pleural-intensity-modulated-radiation-therapy-for-malignant-pleural-mesothelioma
#5
Ellen D Yorke, Andrew Jackson, Li Cheng Kuo, Anthonia Ojo, Kelly Panchoo, Prasad Adusumilli, Marjorie G Zauderer, Valerie W Rusch, Annemarie Shepherd, Andreas Rimner
PURPOSE: To determine clinically helpful dose-volume and clinical metrics correlating with symptomatic radiation pneumonitis (RP) in malignant pleural mesothelioma (MPM) patients with 2 lungs treated with hemithoracic intensity modulated pleural radiation therapy (IMPRINT). METHODS AND MATERIALS: Treatment plans and resulting normal organ dose-volume histograms of 103 consecutive MPM patients treated with IMPRINT (February 2005 to January 2015) to the highest dose ≤50...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28816160/the-impact-of-cardiac-radiation-dosimetry-on-survival-after-radiation-therapy-for-non-small-cell-lung-cancer
#6
S Vivekanandan, D B Landau, N Counsell, D R Warren, A Khwanda, S D Rosen, E Parsons, Y Ngai, L Farrelly, L Hughes, M A Hawkins, J D Fenwick
PURPOSE: The heart receives high radiation doses during radiation therapy of advanced-stage lung cancer. We have explored associations between overall survival, cardiac radiation doses, and electrocardiographic (ECG) changes in patients treated in IDEAL-CRT, a trial of isotoxically escalated concurrent chemoradiation delivering tumor doses of 63 to 73 Gy. METHODS AND MATERIALS: Dosimetric and survival data were analyzed for 78 patients. The whole heart, pericardium, AV node, and walls of left and right atria (LA/RA-Wall) and ventricles (LV/RV-Wall) were outlined on radiation therapy planning scans, and differential dose-volume histograms (dDVHs) were calculated...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28816159/consensus-guidelines-for-implementing-pencil-beam-scanning-proton-therapy-for-thoracic-malignancies-on-behalf-of-the-ptcog-thoracic-and-lymphoma-subcommittee
#7
REVIEW
Joe Y Chang, Xiaodong Zhang, Antje Knopf, Heng Li, Shinichiro Mori, Lei Dong, Hsiao-Ming Lu, Wei Liu, Shahed N Badiyan, Stephen Both, Arturs Meijers, Liyong Lin, Stella Flampouri, Zuofeng Li, Kikuo Umegaki, Charles B Simone, Xiaorong R Zhu
Pencil-beam scanning (PBS) proton therapy (PT), particularly intensity modulated PT, represents the latest advanced PT technology for treating cancers, including thoracic malignancies. On the basis of virtual clinical studies, PBS-PT appears to have great potential in its ability to tightly tailor the dose to the target while sparing critical structures, thereby reducing treatment-related toxicities, particularly for tumors in areas with complicated anatomy. However, implementing PBS-PT for moving targets has several additional technical challenges compared with intensity modulated photon radiation therapy or passive scattering PT...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28816151/quantification-of-pediatric-abdominal-organ-motion-with-a-4-dimensional-magnetic-resonance-imaging-method
#8
Jinsoo Uh, Matthew J Krasin, Yimei Li, Xingyu Li, Christopher Tinkle, John T Lucas, Thomas E Merchant, Chiaho Hua
PURPOSE: To characterize respiration-induced abdominal organ motion in children receiving radiation treatment with a 4-dimensional (4D) magnetic resonance imaging (MRI) method. METHODS AND MATERIALS: We analyzed free-breathing coronal 4D MRI datasets acquired from 35 patients (aged 1-20 years) with abdominal tumors. A deformable image registration of the 4D MRI datasets was performed to derive motion trajectories of selected anatomic landmarks, from which organ motions were quantified...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28816147/evaluating-which-dose-function-metrics-are-most-critical-for-functional-guided-radiation-therapy
#9
Austin M Faught, Tokihiro Yamamoto, Richard Castillo, Edward Castillo, Jingjing Zhang, Moyed Miften, Yevgeniy Vinogradskiy
PURPOSE: Four-dimensional (4D) computed tomography (CT) ventilation imaging is increasingly being used to calculate lung ventilation and implement functional-guided radiation therapy in clinical trials. There has been little exhaustive work evaluating which dose-function metrics should be used for treatment planning and plan evaluation. The purpose of our study was to evaluate which dose-function metrics best predict for radiation pneumonitis (RP). METHODS AND MATERIALS: Seventy lung cancer patients who underwent 4D CT imaging and pneumonitis grading were assessed...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28815994/imrt-qa-using-machine-learning-a-multi-institutional-validation
#10
Gilmer Valdes, Maria F Chan, Seng Boh Lim, Ryan Scheuermann, Joseph O Deasy, Timothy D Solberg
PURPOSE: To validate a machine learning approach to Virtual intensity-modulated radiation therapy (IMRT) quality assurance (QA) for accurately predicting gamma passing rates using different measurement approaches at different institutions. METHODS: A Virtual IMRT QA framework was previously developed using a machine learning algorithm based on 498 IMRT plans, in which QA measurements were performed using diode-array detectors and a 3%local/3 mm with 10% threshold at Institution 1...
August 17, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28812148/local-recurrence-of-squamous-cell-carcinoma-of-the-head-and-neck-after-radio-chemo-therapy-diagnostic-performance-of-fdg-pet-mri-with-diffusion-weighted-sequences
#11
Minerva Becker, Arthur D Varoquaux, Christophe Combescure, Olivier Rager, Marc Pusztaszeri, Karim Burkhardt, Bénédicte M A Delattre, Pavel Dulguerov, Nicolas Dulguerov, Eirini Katirtzidou, Francesca Caparrotti, Osman Ratib, Habib Zaidi, Christoph D Becker
PURPOSE: To determine the diagnostic performance of FDG-PET/MRI with diffusion-weighted imaging (FDG-PET/DWIMRI) for detection and local staging of head and neck squamous cell carcinoma (HNSCC) after radio(chemo)therapy. MATERIALS AND METHODS: This was a prospective study that included 74 consecutive patients with previous radio(chemo)therapy for HNSCC and in whom tumour recurrence or radiation-induced complications were suspected clinically. The patients underwent hybrid PET/MRI examinations with morphological MRI, DWI and FDG-PET...
August 15, 2017: European Radiology
https://www.readbyqxmd.com/read/28811038/fast-and-robust-online-adaptive-planning-in-stereotactic-mr-guided-adaptive-radiation-therapy-smart-for-pancreatic-cancer
#12
O Bohoudi, A M E Bruynzeel, S Senan, J P Cuijpers, B J Slotman, F J Lagerwaard, M A Palacios
BACKGROUND AND PURPOSE: To implement a robust and fast stereotactic MR-guided adaptive radiation therapy (SMART) online strategy in locally advanced pancreatic cancer (LAPC). MATERIAL AND METHODS: SMART strategy for plan adaptation was implemented with the MRIdian system (ViewRay Inc.). At each fraction, OAR (re-)contouring is done within a distance of 3cm from the PTV surface. Online plan re-optimization is based on robust prediction of OAR dose and optimization objectives, obtained by building an artificial neural network (ANN)...
August 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28810243/evaluating-critical-brain-radiation-doses-in-the-treatment-of-multiple-brain-lesions-with-gamma-knife-radiosurgery
#13
Mustafa Aziz Hatiboglu, Kerime Akdur
BACKGROUND: Treatment of patients with multiple brain metastases has shifted to stereotactic radiosurgery, withholding whole-brain (WB) radiation therapy. However, radiation toxicity to the brain is a concern when treating multiple brain lesions with single-fraction stereotactic radiosurgery. OBJECTIVE: The purpose of this study was to determine the changes in brain radiation doses when treating various numbers of targets and lesion volumes. METHODS: We simulated different treatment plans with different combinations of varying tumor volumes including 0...
August 16, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28809759/independent-dose-verification-system-with-monte-carlo-simulations-using-topas-for-passive-scattering-proton-therapy-at-the-national-cancer-center-in-korea
#14
Wook-Geun Shin, Mauro Testa, Hak Soo Kim, Jong Hwi Jeong, Se Byeong Lee, Yeon-Joo Kim, Chul Hee Min
For the independent validation of treatment plans, we developed a Monte Carlo (MC)-based patient dose calculation system with the tool for particle simulation (TOPAS) to enable routine and automatic dose recalculation for each patient. The proton beam nozzle was modeled with TOPAS to simulate the therapeutic beam, and MC commissioning was performed by comparing percent depth dose with the measurement. The beam set-up based on the prescribed beam range and modulation width was automated by modifying the vendor-specific method...
August 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28807748/dosimetric-analysis-and-preliminary-clinical-result-of-image-guided-brachytherapy-with-or-without-hybrid-technique-for-cervical-cancer-using-varisource-titanium-ring-applicator-with-siriraj-ring-cap
#15
Pittaya Dankulchai, Suphalerk Lohasammakul, Janjira Petsuksiri, Pitchayut Nakkrasae, Lalida Tuntipumiamorn, Chumpot Kakanaporn, Yaowalak Chansilpa
PURPOSE: Titanium ring cap applicator (VariSource) was applied in treating cervical cancer patients by using image-guided brachytherapy (IGBT). However, its sizes appeared to be relatively large for most of our patients. Thus, we have developed a specific applicator "Siriraj Ring Cap," which is slightly smaller and more suitable for our patients. This study was to evaluate effectiveness of this equipment. METHODS AND MATERIALS: Locally advanced cervical cancer patients were treated with external beam radiation therapy with or without concomitant chemotherapy...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28807533/evaluation-of-the-effects-of-prostate-radiation-therapy-on-occludin-expression-and-ultrasonography-characteristics-of-the-bladder
#16
Milad Baradaran-Ghahfarokhi, Alireza Amouheidari, Daryoush Shahbazi-Gahrouei, Hamid Reza Baradaran-Ghahfarokhi, Kari Tanderup, Wolfgang Dörr, Parvaneh Shokrani
PURPOSE: To evaluate the effects of radiation dose in prostate radiation therapy (RT) on occludin expression and ultrasonography characteristics of the bladder. METHODS AND MATERIALS: Urine samples of 64 prostate RT patients were collected before, at regular intervals during, and 3 months after RT. Occludin expression analysis was performed, and bladder wall echogenicity and echotexture were investigated by ultrasound and the gray-scale histogram analysis method...
June 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28806822/-multiple-myeloma-current-status-in-diagnostic-testing-and-therapy
#17
Michael Kehrer, Sebastian Koob, Andreas Strauss, Dieter Christian Wirtz, Jan Schmolders
Background Multiple myeloma is a haematological blood cancer of the bone marrow and is classified by the World Health Organisation (WHO) as a plasma cell neoplasm. In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of an abnormal immunoglobulin called monoclonal protein or M protein. This ultimately causes multiple myeloma symptoms such as bone damage or kidney problems. The annual worldwide incidence of multiple myeloma is estimated to be 6 - 7/100,000 and accounts for 1% of all cancer...
August 14, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28802976/prognostic-factors-associated-with-the-accuracy-of-deformable-image-registration-in-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy
#18
Yasuharu Sugawara, Hidenobu Tachibana, Noriyuki Kadoya, Nozomi Kitamura, Amit Sawant, Keiichi Jingu
We evaluated the accuracy of an in-house program in lung stereotactic body radiation therapy (SBRT) cancer patients, and explored the prognostic factors associated with the accuracy of deformable image registrations (DIRs). The accuracy of the 3 programs which implement the free-form deformation and the B-spline algorithm was compared regarding the structures on 4-dimensional computed tomography (4DCT) image datasets between the peak-inhale and peak-exhale phases. The dice similarity coefficient (DSC) and normalized DSC (NDSC) were measured for the gross tumor volumes from 19 lung SBRT patients...
August 9, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28802913/salvage-high-dose-rate-brachytherapy-and-external-beam-radiotherapy-for-isolated-vaginal-recurrences-of-endometrial-cancer-with-no-prior-adjuvant-therapy
#19
Christopher H Chapman, Kaveh Maghsoudi, Ramey D Littell, Lee-May Chen, I-Chow Hsu
PURPOSE: To evaluate clinical outcomes for isolated vaginal recurrence of endometrial cancer without adjuvant therapy treated with salvage external beam radiation therapy (EBRT) and high-dose-rate CT-based inverse-planned brachytherapy. METHODS AND MATERIALS: Thirty women were included in this retrospective study. Median time to first recurrence was 16.7 months, and median age at recurrence was 73 years. Initial grade was 1 or 2 in 19 patients (63%), and 2009 FIGO stage IA in 19 patients...
August 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28801009/management-of-radiation-side-effects-to-the-skin
#20
REVIEW
Tracy Gieger, Michael Nolan
Radiation therapy (RT) is an essential component for management of many cancers. Veterinary health care professionals must counsel owners about the potential side effects of RT, the anticipated management plan, and associated costs. For most veterinary patients treated with RT, acute radiation side effects are mild; however, careful radiation treatment planning and appropriate management of acute side effects are essential to try to prevent chronic sequelae and the need for ongoing wound care. This article reviews acute and late side effects to the skin and their management...
August 9, 2017: Veterinary Clinics of North America. Small Animal Practice
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