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https://www.readbyqxmd.com/read/29679484/the-role-of-autoimmune-reactivity-induced-by-heat-shock-protein-70-in-the-pathogenesis-of-essential-hypertension
#1
REVIEW
Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Autoimmunity is increasingly recognized as having a central role in essential hypertension. Heat shock proteins are immunodominant molecules with high interspecies homology and autoimmune reactivity directed against HSP70 may play a role in the pathogenesis of hypertension. Autoimmunity to HSP70 may result from molecular mimicry between human HSP and bacterial HSP, or alternatively, as a response to HSP70-peptide complexes generated during cellular stress and delivered to the major histocompatibility complex in antigen presenting cells...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29678961/-capn1-mutations-broadening-the-hereditary-spastic-paraplegia-spinocerebellar-ataxia-phenotype
#2
Jeffrey Lambe, Bernadette Monaghan, Tudor Munteanu, Janice Redmond
Increasing availability of next-generation sequencing technologies has revealed several limitations of diagnosis-driven traditional clinicogenetic disease classifications, particularly among patients with an atypical or mixed phenotype. Hereditary spastic paraplegia (HSP) and spinocerebellar ataxia (SCA) are two such disease entities with an often overlapping presentation, in which next generation exome sequencing has played a key role in identification of genes causing disease along a continuum of ataxia and spasticity...
April 20, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29675857/efficacy-and-safety-of-cold-versus-hot-snare-polypectomy-for-resecting-small-colorectal-polyps-systematic-review-and-meta-analysis
#3
REVIEW
Satoshi Shinozaki, Yasutoshi Kobayashi, Yoshikazu Hayashi, Hirotsugu Sakamoto, Alan Kawarai Lefor, Hironori Yamamoto
BACKGROUND AND AIM: The safety and effectiveness of cold snare polypectomy (CSP) compared with hot snare polypectomy (HSP) has been reported. The aim of this study is to perform a meta-analysis of the efficacy and safety of HSP and CSP. METHODS: Randomized-controlled trials were reviewed to compare HSP with CSP for resecting small colorectal polyps. The outcomes reviewed include complete resection rate, polyp retrieval, delayed bleeding, perforation and procedure time...
April 19, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29675023/increased-plasma-levels-of-danger-associated-molecular-patterns-are-associated-with-immune-suppression-and-postoperative-infections-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#4
Guus P Leijte, Hettie Custers, Jelle Gerretsen, Amon Heijne, Johannes Roth, Thomas Vogl, Gert J Scheffer, Peter Pickkers, Matthijs Kox
Introduction: Danger-associated molecular patterns (DAMPs) can elicit immune responses and may subsequently induce an immune-suppressed state. Previous work showed that increased plasma levels of DAMPs are associated with immune suppression and increased susceptibility toward infections in trauma patients. Like trauma, major surgical procedures, such as cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC), are also thought to cause profound DAMP release...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29674508/combined-braf-and-hsp90-inhibition-in-patients-with-unresectable-braf-v600e-mutant-melanoma
#5
Zeynep Eroglu, Yian Ann Chen, Geoffrey T Gibney, Jeffrey S Weber, Ragini R Kudchadkar, Nikhil I Khushalani, Joseph Markowitz, Andrew S Brohl, Leticia F Tetteh, Howida Ramadan, Gina Arnone, Jiannong Li, Xiuhua Zhao, Ritin Sharma, Lancia N F Darville, Bin Fang, Inna Smalley, Jane L Messina, John M Koomen, Vernon K Sondak, Keiran S M Smalley
PURPOSE: BRAF inhibitors are clinically active in patients with advanced BRAFV600 -mutant melanoma, although acquired resistance remains common. Preclinical studies demonstrated that resistance could be overcome using concurrent treatment with the HSP90 inhibitor XL888. METHODS: Vemurafenib (960 mg PO BID) combined with escalating doses of XL888 (30, 45, 90 or 135 mg PO twice weekly) was investigated in 21 patients with advanced BRAFV600 -mutant melanoma. Primary endpoints were safety and determination of a maximum tolerated dose...
April 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29673281/construction-of-rhodococcus-expression-vectors-and-expression-of-the-aminoalcohol-dehydrogenase-gene-in-rhodococcus-erythropolis
#6
Ei-Tora Yamamura
NADP+ -dependent aminoalcohol dehydrogenase (AADH) of Rhodococcus erythropolis MAK154 produces double chiral aminoalcohols, which are used as pharmaceuticals. However, the genetic manipulation of Rhodococcus strains to increase their production of such industrially important enzymes is not well studied. Therefore, I aimed to construct Rhodococcus expression vectors, derived from the Rhodococcus-Escherichia coli shuttle vector pRET1102, to express aadh. The plasmid pRET1102 could be transformed into many actinomycete strains, including R...
April 20, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29670510/differential-expression-of-several-mirnas-and-the-host-genes-aatk-and-dnm2-in-leukocytes-of-sporadic-als-patients
#7
Katarina Vrabec, Emanuela Boštjančič, Blaž Koritnik, Lea Leonardis, Leja Dolenc Grošelj, Janez Zidar, Boris Rogelj, Damjan Glavač, Metka Ravnik-Glavač
Genetic studies have managed to explain many cases of familial amyotrophic lateral sclerosis (ALS) through mutations in several genes. However, the cause of a majority of sporadic cases remains unknown. Recently, epigenetics, especially miRNA studies, show some promising aspects. We aimed to evaluate the differential expression of 10 miRNAs, including miR-9, miR-338, miR-638, miR-663a, miR-124a, miR-143, miR-451a, miR-132, miR-206, and let-7b, for which some connection to ALS was shown previously in ALS culture cells, animal models or patients, and in three miRNA host genes, including C1orf61 (miR-9), AATK (miR-338), and DNM2 (miR-638), in leukocyte samples of 84 patients with sporadic ALS...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29669831/hepatitis-b-virus-core-protein-dephosphorylation-occurs-during-pregenomic-rna-encapsidation
#8
Qiong Zhao, Zhanying Hu, Junjun Cheng, Shuo Wu, Yue Luo, Jinhong Chang, Jianming Hu, Ju-Tao Guo
Hepatitis B virus (HBV) core protein consists of N-terminal assembly domain and C-terminal domain (CTD) with seven conserved serines or threonine that are dynamically phosphorylated/dephosphorylated during the viral replication cycle. Sulfamoylbenzaminde derivatives are small molecular core protein allosteric modulators (CpAMs) that bind to the HAP pocket between the core protein dimer-dimer interfaces. CpAM binding alters the kinetics and pathway of capsid assembly and can result in the formation of morphologically "normal" capsids devoid of viral pregenomic (pg) RNA and DNA polymerase...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29665276/engineered-hsp-protein-nanocages-for-sirna-delivery
#9
Xingang Guan, Yu Chang, Jinghui Sun, Jianxi Song, Yu Xie
The efficient delivery of small interfering RNA (siRNA) to tumor cells still remains a great challenge. Of the various nanocarriers, protein nanocages have attracted extensive interest due to their unique structure and suitable characteristics derived from their proteinaceous nature. However, most reported protein nanocages that are developed are based on virus capsid proteins, which may raise safety concerns, including those related to gene mutation and carcinogenesis. The development of nonviral protein-based systems for siRNA delivery is greatly needed...
April 17, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29664615/non-competitive-effect-of-gambogic-acid-displaces-fluorescence-labelled-atp-but-requires-atp-for-binding-to-hsp90-htpg
#10
Qing Yue, Frank Stahl, Oliver Plettenburg, Andreas Kirschning, Athanasia Warnecke, Carsten Zeilinger
The heat shock protein 90 (Hsp90) family plays a critical role in maintaining the homeostasis of the intracellular environment for human and prokaryotic cells. Hsp90 were identified as important target proteins for cancer and plant disease therapies. It was shown that gambogic acid (GBA) has the potential to inhibit human Hsp90. However, it is unknown, whether it is also able to act on the bacterial high temperature protein (HtpG) analogue. In this work, we screened GBA and nine other novel potential Hsp90 inhibitors using a miniaturized high throughput protein microarray-based assay and found that GBA shows an inhibitory effect on different Hsp90s after dissimilarity analysis of the protein sequence alignment...
April 17, 2018: Biochemistry
https://www.readbyqxmd.com/read/29664511/bullous-henoch-sch%C3%A3-nlein-purpura-case-report
#11
Trinidad Hasbún, Ximena Chaparro, Viera Kaplan, Felipe Cavagnaro, Alex Castro
Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objec tive: To report an unusual cutaneous manifestation of HSP in children. CASE REPORT: A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthral gias...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29663342/associations-of-chronic-urticaria-with-atopic-and-autoimmune-comorbidities-a-nationwide-population-based-study
#12
Hsien-Yi Chiu, Chih-Hsin Muo, Fung-Chang Sung
BACKGROUND: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. OBJECTIVES: This study aims to examine the association between CU, and atopic and autoimmune diseases. METHODS: This population-based retrospective cohort study identified 9,332 patients with CU and 37,328 controls matched for age, sex, and number of dermatological clinic visits from the Taiwan National Health Insurance Research Database for 2004-2009...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29661209/gastrointestinal-and-urinary-complaints-in-adults-with-hereditary-spastic-paraparesis
#13
Øivind J Kanavin, Krister W Fjermestad
BACKGROUND: Hereditary spastic paraparesis (HSP) is a group of rare genetic disorders affecting the central nervous system. Pure HSP is limited to lower limb spasticity and urinary voiding dysfunction. Complex HSP involves additional neurological features. Beyond the described core symptoms, knowledge about the burden of disease for adults with HSP is limited, particularly regarding gastrointestinal functions, fecal incontinence, and urinary symptoms. METHODS: We conducted a cross-sectional self-report survey with 108 adult HSP patients (Mage  = 57...
April 16, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29661187/incidence-and-risk-factors-for-recurrent-henoch-sch%C3%A3-nlein-purpura-in-children-from-a-16-year-nationwide-database
#14
Wei-Te Lei, Po-Li Tsai, Szu-Hung Chu, Yu-Hsuan Kao, Chien-Yu Lin, Li-Ching Fang, Shyh-Dar Shyur, Yu-Wen Lin, Shu-I Wu
BACKGROUND: The recurrence rate of Henoch-Schönlein purpura (HSP) is 2.7%-30%, with varied average intervals between the first and second episodes. Few studies have explored the incidence and risk factors for recurrent HSP. METHODS: We used a 16-year nationwide database to analyze the incidence of recurrent HSP. Patients with HSP were identified, and risk factors for recurrent HSP were explored. Kaplan-Meier and Cox regression model analyses were performed, and covariates were adjusted in the multivariate model...
April 16, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29658585/inhibitors-of-heat-shock-protein-90-augment-endothelin%C3%A2-1%C3%A2-induced-heat-shock-protein-27-through-the-sapk-jnk-signaling-pathway-in-osteoblasts
#15
Kazuhiko Fujita, Takanobu Otsuka, Tetsu Kawabata, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
It has been previously reported that endothelin‑1 (ET‑1) stimulates the induction of heat shock protein (HSP) 27 through the activation of p38 mitogen‑activated protein (MAP) kinase and stress‑activated protein kinase/c‑Jun N‑terminal kinase (SAPK/JNK) in osteoblast‑like MC3T3‑E1 cells. The present study investigated whether HSP90, a high‑molecular‑weight HSP, was implicated in the ET‑1‑stimulated HSP27 induction in MC3T3‑E1 cells. The effects of HSP90 inhibitors on the induction of HSP27 were examined...
April 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29644847/preparation-of-microkernel-based-mesoporous-sio2-cdte-sio2-sio2-fluorescent-nanoparticles-for-imaging-screening-and-enrichment-of-heat-shock-protein-90-inhibitors-from-tripterygium-wilfordii
#16
Yue Hu, Zhao Yi Miao, Xiaojing Zhang, Xiaotong Yang, Yingying Tang, Sheng Yu, ChenXiao Shan, Hongmei Wen, Dong Zhu
The currently utilized ligand fishing for bioactive molecular screening from complex matrixes cannot perform imaging screening. Here, we developed a new solid-phase ligand fishing coupled with in situ imaging protocol for the specific enrichment and identification of heat shock protein 90 (Hsp 90) inhibitors from Tripterygium wilfordii, utilizing a multiple-layer and microkernel-based mesoporous nanostructure composed of a protective silica coating CdTe quantum dots (QDs) core and a mesoporous silica shell, i...
April 12, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29644219/management-of-chemotherapy-induced-left-ventricular-dysfunction-and-heart-failure-in-patients-with-cancer-while-undergoing-cancer-treatment-the-md-anderson-practice
#17
Anecita P Fadol
Chemotherapy-induced cardiotoxicity resulting in heart failure (HF) is one of the most dreaded complications of cancer therapy that can significantly impact morbidity and mortality. With a high prevalence of cardiovascular disease in cancer patients, the risk of developing HF is significantly increased. A new discipline of Onco-Cardiology has evolved to address the cardiovascular needs of patients with cancer, however, there is limited evidence-based data to guide clinical decision-making in the management of the cardiovascular complications of cancer therapy...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29626540/supramolecular-assembly-of-human-pulmonary-surfactant-protein-sp-d
#18
R Arroyo, A Martin-González, M Echaide, A Jain, W H Brondyk, J Rosenbaum, F Moreno-Herrero, J Perez-Gil
Pulmonary surfactant protein D (SP-D) is a glycoprotein from the collectin family that is a component of the lung surfactant system. It exhibits host defense and immune regulatory functions in addition to contributing to the homeostasis of the surfactant pool within the alveolar airspaces. It is known that the SP-D monomer forms trimers, which further associate into higher order oligomers. However, the pathway and the interactions involved in the assembly of SP-D oligomers are not clearly understood. In the current study, a recombinant form of full-length human SP-D (rhSP-D) has been qualitatively and quantitatively studied by Atomic Force Microscopy (AFM) and electrophoresis, with the aim to understand the conformational diversity and the determinants defining the oligomerization of the protein...
April 4, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29622083/role-of-drug-transporters-and-heat-shock-proteins-during-ethanol-exposure-to-human-neural-precursor-cells-and-its-lineages
#19
Sandeep Kumar Vishwakarma, Nusrath Fatima, Chandrakala Lakkireddy, Nagarapu Raju, Avinash Bardia, A Sandhya, Syed Ameer Basha Paspala, Vishnupriya Satti, Aleem Ahmed Khan
INTRODUCTION: Ethanol exposure to developing brain may alter the growth and differentiation of neurological cells resulting in unfavorable pathologies. Earlier studies have provided very limited mechanistic insights of cellular and molecular mechanisms which do not mimic with human situation due to varying cell types and poses potential challenges for investigation. Therefore, the present study was undertaken to evaluate the role of ABC transporters and heat shock proteins mediated response in human neural precursor cells (NPCs) and its lineages during proliferation and lineage differentiation against ethanol exposure...
April 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29621936/colonoscopic-diagnosis-and-reduction-of-recurrent-intussusception-owing-to-henoch-sch%C3%A3-nlein-purpura-without-purpura
#20
Teruyoshi Shimoyama, Nozomi Matsuda, Masashi Kurobe, Takehiko Hayakawa, Masato Nishioka, Masayuki Shimohira, Kei Takasawa
About 50-75% of patients with Henoch-Schönlein purpura (HSP) develop gastro-intestinal symptoms with surgical complications such as intussusception occurring in 0.7-13.6%. In 10-40% of patients, however, gastro-intestinal manifestations may precede the onset of purpura. In patients with gastro-intestinal tract involvement without purpura, confirming the diagnosis of HSP and determining the appropriate treatment remains difficult. A seven-year-old boy presented with recurrent intussusception owing to HSP without purpura...
April 6, 2018: Paediatrics and International Child Health
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