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https://www.readbyqxmd.com/read/29451596/histopathological-characteristics-of-cutaneous-lesions-caused-by-leishmania-viannia-panamensis-in-panama
#1
Kadir González, Rosendo Diaz, Aurea F Ferreira, Víctor García, Héctor Paz, José E Calzada, Michelle Ruíz, Márcia Laurenti, Azael Saldaña
Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V.) panamensis in Panama...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29438905/induction-of-systemic-inflammation-by-hyaluronan-and-hsp70-in-women-with-pre-eclampsia
#2
Mariana Romão-Veiga, Mariana Leticia Matias, Vanessa Rocha Ribeiro, Priscila Rezeck Nunes, Vera Therezinha M Borges, José Carlos Peraçoli, Maria Terezinha S Peraçoli
Pre-eclampsia (PE) is a human pregnancy syndrome with abnormal activation of the innate immune response. The study evaluated the involvement of molecular structures called damage-associated molecular patterns (DAMPs), such as hyaluronan (HA) and heat shock proteins (Hsp) on NLRP1 and NLRP3 inflammasomes activation in peripheral blood monocytes. Twenty pre-eclamptic women, 20 normotensive pregnant women (NT) and 20 non-pregnant women (NP) were studied. Enzyme immunoassay was employed for the determination of HA, Hsp70 and High mobility group Box 1 (HMGB1) in plasma, as well as for the detection of Interleukin-1β (IL-1β), IL-18 and tumor necrosis factor alpha (TNF-α) in the supernatant of monocytes cultured with or without HA and Hsp70...
February 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29438165/histologic-features-of-gastrointestinal-tract-biopsies-in-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura
#3
Christine Y Louie, Adam J Gomez, Richard K Sibley, Dorsey Bass, Teri A Longacre
Immunoglobulin A (IgA) vasculitis or Henoch-Schönlein purpura (HSP) typically occurs in the pediatric population, although rare cases also occur in adults. Gastrointestinal (GI) involvement is common. The "classic" histologic finding in IgA vasculitis (HSP) is leukocytoclastic vasculitis (LCV); other histologic features in biopsies of IgA vasculitis (HSP) have only been rarely described. The pathology archival files at our institution were searched for GI biopsies from patients with IgA vasculitis (HSP)...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29433909/heat-shock-protein-90-inhibitor-enhances-apoptosis-by-inhibiting-the-akt-pathway-in-thermal-stimulated-sk-mel-2-human-melanoma-cell-line
#4
Min Kyung Shin, Ki-Heon Jeong, Hyeongwon Choi, Hye-Jin Ahn, Mu-Hyoung Lee
BACKGROUND: Heat shock proteins (Hsps) are chaperone proteins, which are upregulated after various stresses. Hsp90 inhibitors have been investigated as adjuvant therapies for the treatment of melanoma. Thermal ablation could be a treatment option for surgically unresectable melanoma or congenital nevomelanocytic nevi, however, there is a limitation such as the possibility of recurrence. OBJECTIVE: We evaluated apoptosis in a melanoma cell line treated with the Hsp90 inhibitor 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), in hyperthermic conditions...
February 8, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29432736/mir-223-hsp70-jnk-jun-mir-223-feedback-loop-modulates-the-chemoresistance-of-osteosarcoma-to-cisplatin
#5
Qi Tang, Qi Yuan, Hui Li, Wanchun Wang, Guangrong Xie, Kewei Zhu, Ding Li
Osteosarcoma (OS) is a primary bone malignancy with a five-year survival rate of 60%; the chemoresistance of OS still remains a huge challenge. Heat shock protein 70 (Hsp70), a member of HSP family, is overexpressed in OS cell lines and involved in the resistance of OS cell lines. In addition, miRNAs have been involved in the carcinogenesis and chemoresistance of OS; of them, miR-223 has been reported to be underexpressed and serve as a tumor suppressor in OS through targeting Hsp90B1, also a member of HSP family...
February 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29430581/plagioneurin-b-a-potent-isolated-compound-induces-apoptotic-signalling-pathways-and-cell-cycle-arrest-in-ovarian-cancer-cells
#6
Noraziah Nordin, Nazia Abdul Majid, Rozana Othman, Fatima Abdelmutaal Ahmed Omer, Muhammad Nazil Afiq Nasharuddin, Najihah Mohd Hashim
Plagioneurin B belongs to acetogenin group has well-established class of compounds. Acetogenin group has attracted worldwide attention in the past few years due their biological abilities as inhibitors for several types of tumour cells. Plagioneurin B was isolated via conventional chromatography and tested for thorough mechanistic apoptosis activity on human ovarian cancer cells (CAOV-3). Its structure was also docked at several possible targets using Autodock tools software. Our findings showed that plagioneurin B successfully inhibits the growth of CAOV-3 cells at IC50 of 0...
February 12, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29429543/effect-of-parenteral-glutamine-supplementation-combined-with-enteral-nutrition-on-hsp90-expression-and-peyer-s-patch-apoptosis-in-severely-burned-rats
#7
Jun Fan, Jing Wu, Li-Dong Wu, Bin Cheng, Shao-Yu Tao, Wei Wang, Xi Chen, Peng Zeng, Yi-Bing Wang, Qing-Yan Meng
OBJECTIVES: The aim of this study was to investigate the effects of parenteral glutamine (GLN) supplementation combined with enteral nutrition (EN) on heat shock protein (Hsp) 90 expression and Peyer's patch (PP) apoptosis in severely burned rats. METHODS: Male Sprague-Dawley (SD) rats were randomly assigned to four groups: Sham burn + EN + GLN-free amino acid (AA; n = 10), sham burn + EN + GLN (n = 10), burn + EN + AA (n = 10), and burn + EN + GLN (n = 10)...
March 2018: Nutrition
https://www.readbyqxmd.com/read/29421151/fractional-excretion-as-a-new-marker-of-tubular-damage-in-children-with-chronic-kidney-disease
#8
Kinga Musiał, Danuta Zwolińska
OBJECTIVES: Vitamin D-binding protein (VDBP), retinol-binding protein (RBP)4, and heat shock proteins (hsp) are markers of tubular function and apoptosis, accompanying chronic kidney disease (CKD) from its earliest stages. Fractional excretion of proteins with urine is a marker of tubular damage. The aim of study was to assess the usefulness of fractional excretion (FE) of VDBP, RBP4, HSF1 and Hsp27 as markers of tubular damage in the course of CKD. METHODS: The study group consisted of 70 children with CKD stages 1-5, treated conservatively, and 12 age-matched controls with normal kidney function...
February 6, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29417383/targeted-heat-activation-of-hsp-promoters-in-the-skin-of-mammalian-animals-and-humans
#9
Richard Voellmy, Olivier Zürcher, Manon Zürcher, Pierre A de Viragh, Alexis K Hall, Stephen M Roberts
The use of highly inducible HSP promoters for exerting spatial and/or temporal control over the expression of therapeutic transgenes has long been discussed. Localized and time-limited induction of the heat shock response may potentially also be of medical interest. However, such applications would require targeted delivery of heat doses capable of activating HSP promoters in tissues or organs of interest. Accessible areas, including the skin and tissues immediately underneath it, may be most readily targeted...
February 7, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29416499/a-metadata-analysis-of-oxidative-stress-etiology-in-preclinical-amyotrophic-lateral-sclerosis-benefits-of-antioxidant-therapy
#10
Leila Bond, Kamren Bernhardt, Priyank Madria, Katherine Sorrentino, Hailee Scelsi, Cassie S Mitchell
Oxidative stress, induced by an imbalance of free radicals, incites neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). In fact, a mutation in antioxidant enzyme superoxide dismutase 1 (SOD1) accounts for 20% of familial ALS cases. However, the variance among individual studies examining ALS oxidative stress clouds corresponding conclusions. Therefore, we construct a comprehensive, temporal view of oxidative stress and corresponding antioxidant therapy in preclinical ALS by mining published quantitative experimental data and performing metadata analysis of 41 studies...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29409923/hot-snare-polypectomy-with-or-without-saline-solution-epinephrine-lift-for-the-complete-resection-of-small-colorectal-polyps
#11
Hyun-Soo Kim, Ho Yeon Jung, Hong Jun Park, Hee Man Kim, Jae Ho Seong, Yong Seok Kang, Mee Yon Cho, Min Heui Yu, Dae Ryong Kang
BACKGROUND: /Aim: The criterion standard polypectomy technique for the complete removal of small colorectal polyps has not yet been established. This study aimed to compare the complete resection rate of hot snare polypectomy (HSP) with that of endoscopic mucosal resection (EMR) for small, sessile, or flat polyps. METHODS: Patients with 5-9-mm non-pedunculated colorectal polyps were prospectively randomized to the HSP or EMR group. The presence of residual polyps was assessed by performing histological assessment of 4-quadrant forceps biopsies taken from the edges of the polypectomy site...
February 1, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29409895/bcl-2-associated-athanogene-3-bag3-is-an-enhancer-of-small-heat-shock-protein-turnover-via-activation-of-autophagy-in-the-heart
#12
Yui Inomata, Shouta Nagasaka, Kazuki Miyate, Yuta Goto, Chizuru Hino, Chihiro Toukairin, Rieko Higashio, Kinji Ishida, Tomoyuki Saino, Masamichi Hirose, Hideki Tsumura, Atsushi Sanbe
Bcl-2-associated athanogene 3 (BAG3) is strongly expressed in both cardiac and skeletal muscle. A recent study showed that BAG3 may play a protective role in muscles. Little is known, however, regarding the detailed role of BAG3 in cardiac muscle. To better understand the functional role of cardiac BAG3 in the heart, we generated transgenic (TG) mice that overexpress BAG3. A decrease in fractional shortening, and the induction of cardiac atrial natriuretic peptide, were observed in BAG3 TG mice. Moreover, a marked reduction in the protein level of small HSPs was detected in BAG3 TG mouse hearts...
January 31, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29405094/hspb8-and-bag3-cooperate-to-promote-spatial-sequestration-of-ubiquitinated-proteins-and-coordinate-the-cellular-adaptive-response-to-proteasome-insufficiency
#13
Solenn M Guilbert, Herman Lambert, Marc-Antoine Rodrigue, Margit Fuchs, Jacques Landry, Josée N Lavoie
BCL2-associated athanogene (BAG)-3 is viewed as a platform that would physically and functionally link distinct classes of molecular chaperones of the heat shock protein (HSP) family for the stabilization and clearance of damaged proteins. In this study, we show that HSPB8, a member of the small heat shock protein subfamily, cooperates with BAG3 to coordinate the sequestration of harmful proteins and the cellular adaptive response upon proteasome inhibition. Silencing of HSPB8, like depletion of BAG3, inhibited targeting of ubiquitinated proteins to the juxtanuclear aggresome, a mammalian system of spatial quality control...
February 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29394529/regulation-of-tgf-%C3%AE-smad-mediated-epithelial-mesenchymal-transition-by-celastrol-provides-protection-against-bleomycin-induced-pulmonary-fibrosis
#14
Thomas Divya, Bakthavatchalam Velavan, Ganapasam Sudhandiran
The respiratory disease pulmonary fibrosis (PF), which is characterized by scar formation throughout the lung, imposes a serious health burden. No effective drug without side effects has been proven to prevent this fatal lung disease. In this context, the present study was undertaken to elucidate the protective effect of celastrol, a quinine methide pentacyclic triterpenoid from a Chinese medicinal plant 'thunder God vine' against bleomycin (BLM)-induced PF. We also attempted to study how the cytokine transforming growth factor-β (TGF-β) stimulates fibrosis through the induction of epithelial-mesenchymal transition (EMT) and the role of celastrol in regulating EMT...
February 2, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29394239/matrine-protects-cardiomyocytes-from-ischemia-reperfusion-injury-by-regulating-hsp70-expression-via-activation-of-the-jak2-stat3-pathway
#15
Suping Guo, Chuanyu Gao, Wentao Xiao, Jing Zhang, Yongsheng Qu, Jiang Li, Famin Ye
Studies have shown that matrine showed cardiovascular protective effects; however, its role and mechanism in myocardial ischemia/reperfusion (I/R) injury remain unknown. The Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway activation and elevated heat shock protein (HSP) 70 are closely related to the prevention of myocardial I/R injury. The cardioprotective effects of matrine were determined in hypoxia/reoxygenation (H/R) treated primary rat cardiomyocytes and left anterior descending coronary artery ligation and reperfusion animal models...
February 1, 2018: Shock
https://www.readbyqxmd.com/read/29390330/musculoskeletal-ultrasound-guided-physical-therapy-in-hemiplegic-shoulder-pain-a-care-compliant-case-report
#16
Jingjing Zhang, Yan Li, Hongxing Wang
RATIONALE: The use of musculoskeletal ultrasound (MU) method in the diagnosis of shoulder pain and injury and guidance of injection and pain blocking has been established. However, the treatment of posthemiplegic shoulder pain (HSP) with MU-guided precise physical therapy has not been reported. PATIENT CONCERNS: Here, we present the first case report of a 64-year-old man with a right basal ganglia hemorrhage. Left side shoulder pain remained unbearable, which seriously affected sleep and shoulder-related activities...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386501/emodin-a-chinese-herbal-medicine-inhibits-reoxygenation-induced-injury-in-cultured-human-aortic-endothelial-cells-by-regulating-the-peroxisome-proliferator-activated-receptor-%C3%AE-ppar-%C3%AE-and-endothelial-nitric-oxide-synthase-enos-signaling-pathway
#17
Xiaoling Shou, Rongfang Zhou, Liyue Zhu, Aihua Ren, Lei Wang, Yan Wang, Jianmei Zhou, Xinwen Liu, Bozhong Wang
BACKGROUND Ischemia-reperfusion injury is associated with vascular dysfunction. The aim of this study was to investigate the role of emodin, a Chinese herbal medicine, in hypoxia-reoxygenation injury in cultured human aortic endothelial cells (HAECs) and its effects on the expression of the peroxisome proliferator-activated receptor-γ (PPAR-γ) and endothelial nitric oxide synthase (eNOS) signaling pathway. MATERIAL AND METHODS An in vitro hypoxia-reoxygenation model used cultured human aortic endothelial cells (HAECs)...
February 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29386344/synergistic-role-of-hsp90%C3%AE-and-hsp90%C3%AE-to-promote-myofibroblast-persistence-in-lung-fibrosis
#18
Pierre-Simon Bellaye, Chiko Shimbori, Toyoshi Yanagihara, David A Carlson, Philip Hughes, Chandak Upagupta, Seidai Sato, Nolan Wheildon, Timothy Haystead, Kjetil Ask, Martin Kolb
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the lung parenchyma, causing significant morbidity through worsening dyspnoea and overall functional decline. IPF is characterised by apoptosis-resistant myofibroblasts, which are a major source for the excessive production of extracellular matrix (ECM) overtaking normal lung tissue. We sought to study the role of heat shock protein (HSP) isoforms HSP90α and HSP90β, whose distinct roles in lung fibrogenesis remain elusive.We determined the level of circulating HSP90α in IPF patients (n=31) and age-matched healthy controls (n=9) by ELISA...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29385708/differential-glycosylation-and-modulation-of-camel-and-human-hsp-isoforms-in-response-to-thermal-and-hypoxic-stresses
#19
Abdullah Hoter, Mahdi Amiri, Abdelbary Prince, Hassan Amer, Mohamad Warda, Hassan Y Naim
Increased expression of heat shock proteins (HSPs) following heat stress or other stress conditions is a common physiological response in almost all living organisms. Modification of cytosolic proteins including HSPs by O-GlcNAc has been shown to enhance their capabilities for counteracting lethal levels of cellular stress. Since HSPs are key players in stress resistance and protein homeostasis, we aimed to analyze their forms at the cellular and molecular level using camel and human HSPs as models for efficient and moderate thermotolerant mammals, respectively...
January 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29385268/selective-extraction-of-high-value-phenolic-compounds-from-distillation-wastewater-of-basil-ocimum-basilicum-l-by-pressurized-liquid-extraction
#20
Imma Pagano, Andrea Del Pilar Sánchez-Camargo, Jose Antonio Mendiola, Luca Campone, Alejandro Cifuentes, Luca Rastrelli, Elena Ibañez
During the essential oil steam distillation from aromatic herbs, huge amounts of distillation wastewaters (DWWs) are generated. These by-products represent an exceptionally rich source of phenolic compounds such as rosmarinic acid (RA) and caffeic acid (CA). Herein, the alternative use of dried basil DWWs (dDWWs) to perform a selective extraction of RA and CA by pressurized liquid extraction (PLE) employing bio-based solvent was studied. To select the most suitable solvent for PLE, the theoretical modelling of Hansen solubility parameters (HSP) was carried out...
January 31, 2018: Electrophoresis
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