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https://www.readbyqxmd.com/read/29036860/prevalence-of-work-related-musculoskeletal-injuries-among-south-indian-hand-screen-printing-workers
#1
S Shankar, R Naveen Kumar, P Mohankumar, Srinivasan Jayaraman
BACKGROUND: Hand screen-printing (HSP) plays a predominant role in textile industries in developing countries. Workers from HSP industry were mostly affected by musculoskeletal injury due to monotonous, and prolonged work nature and poor workplace environment. OBJECTIVE: The present study aims to investigate the prevalence of work-related musculoskeletal disorder (MSD) symptoms and risk factors associated among the HSP industry workers. METHODS: Cochran's sample size for categorical data was used to select 385 HSP workers of 1000 samples from various provinces of Tamil Nadu, INDIA...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036317/quality-of-local-school-wellness-policies-for-physical-activity-and-resultant-implementation-in-pennsylvania-schools
#2
E Francis, E Hivner, A Hoke, T Ricci, A Watach, J Kraschnewski
Background: In 2006, United States public schools participating in federal school meal programs were required to adopt school wellness policies. The effect of these policies on school nutrition environments is well documented; however, evaluation of physical activity policies has received less investigation. We aimed to evaluate how district wellness policies aligned to practice for physical activity implementation in 40 schools with high obesity rates (>24%). Methods: Wellness policies were evaluated using the validated Wellness School Assessment Tool (WellSAT)...
September 28, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29034544/cyp2u1-activity-is-altered-by-missense-mutations-in-hereditary-spastic-paraplegia-56
#3
Christelle M Durand, Laura Dhers, Christelle Tesson, Alessandra Tessa, Laetitia Fouillen, Stéphanie Jacqueré, Laure Raymond, Isabelle Coupry, Giovanni Benard, Frédéric Darios, Khalid H El-Hachimi, Guja Astrea, François Rivier, Guillaume Banneau, Claire Pujol, Didier Lacombe, Alexandra Durr, Patrick J Babin, Filippo M Santorelli, Nicolas Pietrancosta, Jean-Luc Boucher, Daniel Mansuy, Giovanni Stevanin, Cyril Goizet
Hereditary Spastic Paraplegia (HSP) is an inherited disorder of the central nervous system mainly characterized by gradual spasticity and weakness of the lower limbs. SPG56 is a rare autosomal recessive early onset complicated form of HSP caused by mutations in CYP2U1. The CYP2U1 enzyme was shown to catalyze the hydroxylation of arachidonic acid. Here, we report two further SPG56 families carrying 3 novel CYP2U1 missense variants and the development of an in vitro biochemical assay to determine the pathogenicity of missense variants of uncertain clinical significance...
October 16, 2017: Human Mutation
https://www.readbyqxmd.com/read/29034530/gene-expression-and-morphological-changes-in-the-intestinal-mucosa-associated-with-increased-permeability-induced-by-short-term-fasting-in-chickens
#4
S Gilani, G S Howarth, G Nattrass, S M Kitessa, R Barekatain, R E A Forder, C D Tran, R J Hughes
Short-term fasting for 4.5 and 9 hr has been demonstrated to increase intestinal permeability (IP) in chickens. This study aimed to investigate the effects of 0, 4.5, 9 and 19.5 hr fasting on intestinal gene expression and villus-crypt architecture of enterocytes in jejunal and ileal samples. On day 38, Ross-308 male birds were fasted according to their group and then euthanised. Two separate intestinal sections (each 2 cm long, jejunum and ileum) were collected. One section was utilised for villus height and crypt depth measurements...
October 16, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29034430/ultraviolet-filters-and-heat-shock-proteins-effects-in-chironomus-riparius-by-benzophenone-3-and-4-methylbenzylidene-camphor
#5
Raquel Martín-Folgar, Mónica Aquilino, Irene Ozáez, José-Luis Martínez-Guitarte
Benzophenone-3 (BP3) and 4-methylbenzylidene camphor (4MBC) are common ultraviolet filters (UV filters), compounds considered as emergent contaminants, used in different products like plastics and personal care products. The levels of these compounds are rising in the wild, but the effects they have on invertebrates are poorly understood. Chironomus riparius is a benthic insect widely used in toxicology, and several studies have been previously performed in our laboratory to determine the effects these compounds have on this organism at the molecular level...
October 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29034286/data-of-indirect-immunofluorescence-labeling-of-the-mouse-brain-sections-with-sera-from-sle-and-ms-patients
#6
Ayse Ilksen Colpak, Banu Balci-Peynircioglu, Alp Can, Yasemin Gursoy-Ozdemir, Sevda Lule, Umut Kalyoncu, Turgay Dalkara
The data presented in this article are related to the research article entitled "Behcet Disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger" (Lule et a. 2017) [1]. The immunoreactivity to self-antigens is well characterized for systemic lupus erythematosus (SLE) and multiple sclerosis (MS) (Magro Checa et al., 2013) [2]. Indirect immunofluorescence labeling of the mouse tissue sections with patient sera has recently been popular to discover novel epitopes and gain mechanistic insight to diseases with dysregulated immunity (Lennon et al...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29032866/hsp90-maintains-boar-spermatozoa-motility-and-mitochondrial-membrane-potential-during-heat-stress
#7
V Calle-Guisado, M J Bragado, L J García-Marín, L González-Fernández
Heat Shock Proteins (HSP) is a family of proteins that protects cells from high temperatures. The present work aimed to elucidate the role that HSP90 exerts on boar sperm incubated under heat stress conditions on viability, total motility (TM), progressive motility (PM), acrosome status, mitochondrial membrane potential and plasma membrane lipid organization. Sperm were incubated in non-capacitating conditions (Tyrode's basal medium or TBM) for 3, 8 and 24h or in capacitating conditions (Tyrode's complete medium or TCM) for 4h at 38...
September 29, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29024008/immunization-with-%C3%AE-synuclein-grp94-reshapes-peripheral-immunity-and-suppresses-microgliosis-in-a-chronic-parkinsonism-model
#8
Javier Villadiego, Adahir Labrador-Garrido, Jaime M Franco, Magdalena Leal-Lasarte, Erwin J De Genst, Christopher M Dobson, David Pozo, Juan J Toledo-Aral, Cintia Roodveldt
Neuroinflammation mediated by chronically activated microglia, largely caused by abnormal accumulation of misfolded α-synuclein (αSyn) protein, is known to contribute to the pathophysiology of Parkinson's disease (PD). In this work, based on the immunomodulatory activities displayed by particular heat-shock proteins (HSPs), we tested a novel vaccination strategy that used a combination of αSyn and Grp94 (HSPC4 or Gp96) chaperone and a murine PD model. We used two different procedures, first, the adoptive transfer of splenocytes from αSyn/Grp94-immunized mice to recipient animals, and second, direct immunization with αSyn/Grp94, to study the effects in a chronic mouse MPTP-model of parkinsonism...
October 11, 2017: Glia
https://www.readbyqxmd.com/read/29023475/de-novo-transcriptome-sequencing-of-isaria-cateniannulata-and-comparative-analysis-of-gene-expression-in-response-to-heat-and-cold-stresses
#9
Dingfeng Wang, Liangde Li, Guangyuan Wu, Liette Vasseur, Guang Yang, Pengrong Huang
Isaria cateniannulata is a very important and virulent entomopathogenic fungus that infects many insect pest species. Although I. cateniannulata is commonly exposed to extreme environmental temperature conditions, little is known about its molecular response mechanism to temperature stress. Here, we sequenced and de novo assembled the transcriptome of I. cateniannulata in response to high and low temperature stresses using Illumina RNA-Seq technology. Our assembly encompassed 17,514 unigenes (mean length = 1,197 bp), in which 11,445 unigenes (65...
2017: PloS One
https://www.readbyqxmd.com/read/29020644/di-2-ethylhexyl-phthalate-and-diethyl-phthalate-disrupt-lipid-metabolism-reduce-fecundity-and-shortens-lifespan-of-caenorhabditis-elegans
#10
Ajay Pradhan, Per-Erik Olsson, Jana Jass
The widespread use of phthalates is of major concern as they have adverse effects on many different physiological functions, including reproduction, metabolism and cell differentiation. The aim of this study was to compare the toxicity of the widely-used di (2-ethydlhexyl) phthalate (DEHP) with its substitute, diethyl phthalate (DEP). We analyzed the toxicity of these two phthalates using Caenorhabditis elegans as a model system. Gene expression analysis following exposure during the L1 to young adult stage showed that DEHP and DEP alter the expression of genes involved in lipid metabolism and stress response...
September 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29020622/homeostatic-presynaptic-plasticity-is-specifically-regulated-by-p-q-type-ca-2-channels-at-mammalian-hippocampal-synapses
#11
Alexander F Jeans, Fran C van Heusden, Bashayer Al-Mubarak, Zahid Padamsey, Nigel J Emptage
Voltage-dependent Ca(2+) channels (VGCC) represent the principal source of Ca(2+) ions driving evoked neurotransmitter release at presynaptic boutons. In mammals, presynaptic Ca(2+) influx is mediated mainly via P/Q-type and N-type VGCC, which differ in their properties. Changes in their relative contributions tune neurotransmission both during development and in Hebbian plasticity. However, whether this represents a functional motif also present in other forms of activity-dependent regulation is unknown. Here, we study the role of VGCC in homeostatic plasticity (HSP) in mammalian hippocampal neurons using optical techniques...
October 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/29020081/heat-stress-induces-expression-of-hsp-genes-in-genetically-divergent-chickens
#12
Haniel Cedraz, Juliana Gracielle Gonzaga Gromboni, Antonio Amandio Pinto Garcia, Ronaldo Vasconcelos Farias Filho, Teillor Machado Souza, Eduardo Ribeiro de Oliveira, Elizangela Bonfim de Oliveira, Carlos Souza do Nascimento, Camila Meneghetti, Amauri Arias Wenceslau
BACKGROUND: Chickens are animals that are sensitive to thermal stress, which may decrease their production level in terms that it affects feed intake and thus, decreasing body weight gain. The Heat Shock Factors (HSF) and Heat Shock Proteins (HSP) genes are involved in the key cellular defense mechanisms during exposure in hot environments. Aimed with this study to analyze the expression of HSF1, HSF3, HSP70 and HSP90 genes in two local breeds (Peloco and Caneluda) and a commercial broiler line (Cobb 500®) to verify differences in resistance of these chicken to Heat stress treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29017815/rna-polymerase-ii-pausing-and-transcriptional-regulation-of-the-hsp70-expression
#13
REVIEW
Heeyoun Bunch
Heat-shock proteins (HSPs) belong to the chaperone protein family whose expression is induced by different stresses including heat-shock. In response to the extracellular or intrinsic stimuli and stresses, HSPs play important roles in the maintenance of cellular homeostasis. HSP70, a major HSP protein (molecular weight, 70 KDa), regulates diverse cellular pathways including protein quality control, translation, immune response, and cancer survival. As a critical cellular defense system to minimize damages from cellular stresses, HSP70 expression and transcriptional activation are rapidly regulated, mainly through the action of a transcription activator, Heat shock factor 1 (HSF1)...
October 3, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28994403/large-scale-crystallization-and-neutron-crystallographic-analysis-of-hsp70-in-complex-with-adp
#14
Takeshi Yokoyama, Andreas Ostermann, Tobias E Schrader, Mineyuki Mizuguchi
HSP70 belongs to the heat-shock protein family and binds to unfolded proteins, driven by ATP hydrolysis, in order to prevent aggregation. Previous X-ray crystallographic analyses of HSP70 have shown that HSP70 binds to ADP with internal water molecules. In order to elucidate the role of the water molecules, including their H/D atoms, a neutron diffraction study of the human HSP70 ATPase domain was initiated. Deuterated large crystals of the HSP-ADP complex (1.2-1.8 mm(3)) were successfully grown by large-scale crystallization, and a neutron diffraction experiment at BIODIFF resulted in diffraction to a maximum resolution of 2...
October 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28990845/the-relationship-between-red-cell-distribution-width-and-the-risk-of-henoch-sch%C3%A3-nlein-purpura-nephritis
#15
X Zhu, M Zhang, F Lan, H Wei, Q He, S Li, X Qin
INTRODUCTION: Red blood cell distribution width (RDW) is elevated in various inflammatory diseases, but its clinical significance in Henoch-Schönlein purpura nephritis (HSPN) in unknown. The aim of this study was to determine the value of RDW as a risk factor or marker for HSPN in children. METHODS: This was a case-control study of 105 Henoch-Schönlein purpura (HSP) patients, 120 HSPN patients and 192 healthy controls. The relationship between RDW-coefficient of variation (RDW-CV) and the clinical characteristics of HSPN patients was determined by a multiple logistic regression analysis (MVLRA)...
October 9, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28987383/hsp90-inhibitor-nvp-auy922-enhances-the-anti-cancer-effect-of-bcl-2-inhibitor-abt-737-in-small-cell-lung-cancer-expressing-bcl-2
#16
Hannah Yang, Mi-Hee Lee, Intae Park, Hanwool Jeon, Junyoung Choi, Seyoung Seo, Sang-We Kim, Gou Young Koh, Kang-Seo Park, Dae Ho Lee
Small cell lung cancer (SCLC) cannot be efficiently controlled using existing chemotherapy and radiotherapy approaches, indicating the need for new therapeutic strategies. Although ABT-737, a B-cell lymphoma-2 (BCL-2) inhibitor, exerts anticancer effects against BCL-2-expressing SCLC, monotherapy with ABT-737 is associated with limited clinical activity because of the development of resistance and toxicity. Here, we examined whether combination therapy with ABT-737 and heat shock protein 90 (HSP90) inhibitor NVP-AUY922 exerted synergistic anticancer effects on SCLC...
October 4, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28984999/direct-immunofluorescence-testing-in-vasculitis-a-single-institution-experience-with-henoch-sch%C3%A3-nlein-purpura
#17
Patrick Feasel, Steven D Billings, Wilma F Bergfeld, Melissa P Piliang, Anthony P Fernandez, Jennifer S Ko
BACKGROUND: Direct immunofluorescence (DIF) panels (IgG, IgA, IgM, C3 and fibrinogen) are ordered for clinically suspected vasculitis, with frequently negative results. METHODS: Cases submitted for DIF and histology (2010-2014) with "vasculitis" in the clinical data were examined, and the electronic medical record reviewed for clinical suspicion of HSP. Peri/intravascular IgA was considered "positive," other reactants "non-specific," and no immunoreactivity "negative...
October 6, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28984389/binding-of-trace-elements-ag-cd-co-cu-ni-and-tl-to-cytosolic-biomolecules-in-livers-of-juvenile-yellow-perch-perca-flavescens-collected-from-lakes-representing-metal-contamination-gradients
#18
Antoine Caron, Maikel Rosabal, Ophélie Drevet, Patrice Couture, Peter G C Campbell
Biomolecules involved in handling cytosolic metals in the liver of the yellow perch (Perca flavescens) were characterized in juvenile fish collected from four lakes constituting metal contamination gradients. Using size-exclusion liquid chromatography coupled to an inductively-coupled mass spectrometer (SEC-ICP-MS), we determined metal distributions among ligands of different molecular weights in the cytosol, before and after a heat denaturation step designed to isolate metallothionein-like peptides and proteins (MTLPs)...
October 6, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28980915/functional-role-of-inflammation-in-the-surgical-injury-induced-vascular-remodeling-of-male-albino-rats
#19
X Song, L Li, Y Wu, L Zhang, X Li
Our present study investigates the cellular and molecular inflammatory events in male albino rat arterial injury. Male albino rats were subjected to longitudinal incision and carotid artery clamping for the duration of 45 days. Heat shock protein (HSP) 27, HSP70, HSP47 and Nuclear Factor kappa B (NF-κB) expressions were determined by qPCR and Western blot method. The morphology of vessel wall alteration was studied by the light microscopy. The expression of NF-κB was found to be increased after ten days of carotid artery injury...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28980718/identification-of-over-expressed-proteins-in-oral-submucous-fibrosis-by-proteomic-analysis
#20
Tapasi Das, Chandraday Prodhan, Santunu Patsa, Jay Gopal Ray, Keya Chaudhuri
Early detection and identification of oral pre-malignancy or malignancy help in management of the disease and improve survival rates. Oral submucous fibrosis (OSMF) is a major threat to public health worldwide and especially in Southeast Asian countries. Identification of biomarkers is a necessary step towards early diagnosis and treatment. In this study, differentially expressed proteins between oral submucous fibrotic tissue and normal control tissues were recorded by proteomic analysis using two dimensional electrophoresis (2DE) and MALDI TOF mass spectrometry...
October 5, 2017: Journal of Cellular Biochemistry
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