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https://www.readbyqxmd.com/read/28212588/colorectal-polypectomy-and-endoscopic-mucosal-resection-emr-european-society-of-gastrointestinal-endoscopy-esge-clinical-guideline
#1
Monika Ferlitsch, Alan Moss, Cesare Hassan, Pradeep Bhandari, Jean-Marc Dumonceau, Gregorios Paspatis, Rodrigo Jover, Cord Langner, Maxime Bronzwaer, Kumanan Nalankilli, Paul Fockens, Rawi Hazzan, Ian M Gralnek, Michael Gschwantler, Elisabeth Waldmann, Philip Jeschek, Daniela Penz, Denis Heresbach, Leon Moons, Arnaud Lemmers, Konstantina Paraskeva, Juergen Pohl, Thierry Ponchon, Jaroslaw Regula, Alessandro Repici, Matthew D Rutter, Nicholas G Burgess, Michael J Bourke
1 ESGE recommends cold snare polypectomy (CSP) as the preferred technique for removal of diminutive polyps (size ≤ 5 mm). This technique has high rates of complete resection, adequate tissue sampling for histology, and low complication rates. (High quality evidence, strong recommendation.) 2 ESGE suggests CSP for sessile polyps 6 - 9 mm in size because of its superior safety profile, although evidence comparing efficacy with hot snare polypectomy (HSP) is lacking. (Moderate quality evidence, weak recommendation...
February 17, 2017: Endoscopy
https://www.readbyqxmd.com/read/28204829/heat-shock-protein-90-akt-pathway-participates-in-the-cardioprotective-effect-of-exogenous-hydrogen-sulfide-against-high-glucose-induced-injury-to-h9c2-cells
#2
Xiao Ke, Jingfu Chen, Longyun Peng, Wei Zhang, Yiying Yang, Xinxue Liao, Liqiu Mo, Ruixian Guo, Jianqiang Feng, Chengheng Hu, Ruqiong Nie
It has been reported that exogenous hydrogen sulfide (H2S) protects against high glucose (HG)-induced cardiac injury and has a modulatory effect on heat shock protein (HSP) and Akt, which play a cardioprotective role. In this study, we examined whether the HSP90/Akt pathway contributes to the protective effects of exogenous H2S against HG-induced injury to H9c2 cardiac cells. Our results revealed that the exposure of H9c2 cardiac cells to 35 mM glucose (HG) for 1 to 24 h decreased the expression of HSP90 and markedly reduced the expression level of phosphorylated (p)-Akt in a time-dependent manner...
February 15, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28203340/the-relationship-of-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-with-gastrointestinal-bleeding-in-henoch-schonlein-purpura
#3
Ozlem Bostan Gayret, Meltem Erol, Hikmet Tekin Nacaroglu
OBJECTIVES: Henoch-Schonlein Purpura (HSP) is the most widespread systemic vasculitis during childhood. Gastrointestinal tract retention and gastrointestinal bleeding are among its major complications. Neutrophil-Lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are indicators related to inflammatory diseases. This study evaluated the relationship between NLR or PLR and gastrointestinal bleeding in HSP. METHODS: The study consisted of 119 patients and 40 healthy children in the same age group...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28199794/the-cellular-stress-response-of-rat-skeletal-muscle-following-lengthening-contractions
#4
Evan Pollock-Tahiri, Marius Locke
The cellular stress response (CSR) of the rat tibialis anterior (TA) muscle was investigated following 20, 40 or 60 lengthening contractions (LCs) using an in-vivo model of electrical stimulation. Muscles were removed at 0, 1, 3, or 24 hours after LCs and assessed for HSF activation, HSP content and/or morphological evidence of muscle fibre damage. When compared to the first muscle contraction, peak muscle torque was reduced by 26% (p<0.05) after 20 LCs and further reduced to 56% and 60% (p<0.001) after 40 and 60 LCs, respectively...
February 15, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28195947/alpha-msh-induces-vasodilatation-and-exerts-cardioprotection-via-the-heme-oxygenase-pathway-in-rat-hearts
#5
Miklos Vecsernyes, Miklos Szokol, Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Gabor Aron Fulop, Balazs Varga, Bela Juhasz, David Haines, Arpad Tosaki
Alpha-melanocyte-stimulating hormone (α-MSH) is a protein with known capacity for protection against cardiovascular ischemia-reperfusion (I/R) injury. The present investigation evaluates the capacity of α-MSH to mitigate I/R effects in an isolated working rat heart model and determine the dependency of these alterations on the activity of heme oxygenase-1 (HO-1, hsp-32), a heat shock protein that functions as a major antioxidant defense molecule. Healthy male Sprague-Dawley rats were used for all experiments...
February 13, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28194725/otophylloside-b-protects-against-a%C3%AE-toxicity-in-caenorhabditis-elegans-models-of-alzheimer-s-disease
#6
Jie Yang, Xiao-Bing Huang, Qin-Li Wan, Ai-Jun Ding, Zhong-Lin Yang, Ming-Hua Qiu, Hua-Ying Sun, Shu-Hua Qi, Huai-Rong Luo
Alzheimer's disease (AD) is a major public health concern worldwide and the few drugs currently available only treat the symptoms. Hence, there is a strong need to find more effective anti-AD agents. Cynanchum otophyllum is a traditional Chinese medicine for treating epilepsy, and otophylloside B (Ot B), isolated from C. otophyllum, is the essential active component. Having previously identified anti-aging effects of Ot B, we evaluated Ot B for AD prevention in C. elegans models of AD and found that Ot B extended lifespan, increased heat stress-resistance, delayed body paralysis, and increased the chemotaxis response...
February 13, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28191532/the-role-of-heat-shock-proteins-in-kidney-disease
#7
REVIEW
Shobhana Nayak Rao
Heat Shock Proteins (HSP) belong to the family of intracellular proteins that are constitutively expressed and are upregulated by various stressors including heat, oxidative and chemical stress. HSP helps in reparative processes, including the refolding of damaged proteins and the removal of irreparably damaged proteins that would initiate cellular death or apoptosis. A growing body of evidence has expanded the role of HSP and defined their role in diseases such as neurodegenerative disorders, cancer, ischemic heart disease and kidney diseases...
September 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28182573/amplified-canonical-transforming-growth-factor-%C3%AE-signalling-via-heat-shock-protein-90-in-pulmonary-fibrosis
#8
Zaneta Sibinska, Xia Tian, Martina Korfei, Baktybek Kojonazarov, Janina Susanne Kolb, Walter Klepetko, Djuro Kosanovic, Malgorzata Wygrecka, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Andreas Guenther, Ralph T Schermuly
Interstitial lung fibroblast activation coupled with extracellular matrix production is a pathological signature of idiopathic pulmonary fibrosis (IPF), and is governed by transforming growth factor (TGF)-β/Smad signalling. We sought to define the role of heat shock protein (HSP)90 in profibrotic responses in IPF and to determine the therapeutic effects of HSP90 inhibition in a murine model of pulmonary fibrosis.We investigated the effects of HSP90 inhibition in vitro by applying 17-AAG (17-allylamino-17-demethoxygeldanamycin) to lung fibroblasts and A549 cells and in vivo by administering 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin) to mice with bleomycin-induced pulmonary fibrosis...
December 19, 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28182003/luteolin-selectively-kills-stat3-highly-activated-gastric-cancer-cells-through-enhancing-the-binding-of-stat3-to-shp-1
#9
Shiyu Song, Zhonglan Su, Hui Xu, Mengyuan Niu, Xiufang Chen, Haiyan Min, Bin Zhang, Guibo Sun, Sijing Xie, Hongwei Wang, Qian Gao
The antitumor effect of luteolin, a plant flavonoid, in gastric cancer (GC) cells has not been fully understood. Here we show that luteolin selectively kills STAT3 overactivated GC cells that are often drug resistant. The treatment of luteolin in these GC cells significantly inhibited STAT3 phosphorylation and reduced the expression of STAT3 targeting gene Mcl-1, Survivin and Bcl-xl. Silencing of SHP-1, a protein tyrosine phosphatase, abolished the inhibitory effect of luteolin on STAT3 and cell apoptosis, suggesting that SHP-1 is crucial in luteolin-mediated cellular function...
February 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28178571/genome-wide-identification-and-analysis-of-biotic-and-abiotic-stress-regulation-of-small-heat-shock-protein-hsp20-family-genes-in-bread-wheat
#10
Senthilkumar K Muthusamy, Monika Dalal, Viswanathan Chinnusamy, Kailash C Bansal
Small Heat Shock Proteins (sHSPs)/HSP20 are molecular chaperones that protect plants by preventing protein aggregation during abiotic stress conditions, especially heat stress. Due to global climate change, high temperature is emerging as a major threat to wheat productivity. Thus, the identification of HSP20 and analysis of HSP transcriptional regulation under different abiotic stresses in wheat would help in understanding the role of these proteins in abiotic stress tolerance. We used sequences of known rice and Arabidopsis HSP20 HMM profiles as queries against publicly available wheat genome and wheat full length cDNA databases (TriFLDB) to identify the respective orthologues from wheat...
January 22, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28177659/effects-of-ferulic-acid-on-oxidative-stress-heat-shock-protein-70-connexin-43-and-monoamines-in-hippocampus-of-pentylenetetrazole-kindled-rats
#11
Abdelaziz M Hussein, Khalid M Abbas, Osama A Abulseoud, Elhussainy Mohamed Abouelez Elhussainy
The present study investigated the effects of ferulic acid on pentylenetetrazole (PTZ)-induced seizures, oxidative stress markers (malondialdhyde (MDA), catalase (CAT) and reduced glutathione (GSH)), connexin (Cx) 43, heat shock protein (Hsp) 70 and monoamines (serotonin (5HT) and norepinephrine (NE) levels in a rat model of PTZ-induced kindling. Sixty Sprague Dawley rats were divided into 5 equal groups, a) normal group, b) FA group: normal rats received FA at a dose of 40 mg/kg daily, c) PTZ group: rats received PTZ at a dose of 50 mg/kg i...
February 3, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28174414/a-case-of-henoch-schonlein-purpura-associated-with-rotavirus-infection-in-an-elderly-asian-male-and-review-of-the-literature
#12
Chen Tang, Daphne Scaramangas-Plumley, Cynthia C Nast, Zab Mosenifar, Marc A Edelstein, Michael Weisman
BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint pain, and hematuria. The disease most commonly targets children but can affect adults who tend to have a worse prognosis. CASE REPORT We discuss a case of HSP in an elderly Chinese male who presented with severe proximal bowel inflammation, vasculitic rash, and proteinuria; he was found to have positive stool rotavirus and giardia...
February 8, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28166442/exosomes-in-cancer-theranostic-diamonds-in-the-rough
#13
Marine Cordonnier, Gaëtan Chanteloup, Nicolas Isambert, Renaud Seigneuric, Pierre Fumoleau, Carmen Garrido, Jessica Gobbo
During the last 10 years, exosomes, which are small vesicles of 50-200 nm diameter of endosomal origin, have aroused a great interest in the scientific and clinical community for their roles in intercellular communication in almost all physiological and pathological processes. Most cells can potentially release these nanovesicles that share with the parent cell a similar lipid bilayer with transmembrane proteins and a panel of enclosed soluble proteins such as heat shock proteins and genetic material, thus acting as potential nanoshuttles of biomarkers...
February 6, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28166240/involvement-of-multiple-stressors-induced-by-non-thermal-plasma-charged-aerosols-during-inactivation-of-airborne-bacteria
#14
Nachiket D Vaze, Sin Park, Ari D Brooks, Alexander Fridman, Suresh G Joshi
A lab-scale, tunable, single-filament, point-to-point nonthermal dieletric-barrier discharge (DBD) plasma device was built to study the mechanisms of inactivation of aerosolized bacterial pathogens. The system inactivates airborne antibiotic-resistant pathogens efficiently. Nebulization mediated pre-optimized (4 log and 7 log) bacterial loads were challenged to plasma-charged aerosols, and lethal and sublethal doses determined using colony assay, and cell viability assay; and the loss of membrane potential and cellular respiration were determined using cell membrane potential assay and XTT assay...
2017: PloS One
https://www.readbyqxmd.com/read/28162051/henoch-schonlein-purpura-post-streptococcal-glomerulonephritis-and-acute-rheumatic-carditis-after-group-a-%C3%AE-haemolytic-streptococcal-infection
#15
Seçil Arslansoyu Çamlar, Alper Soylu, İpek Akil, Mehtat Ünlü, Şenol Coşkun, Pelin Ertan, Salih Kavukçu
Besides association with acute rheumatic fever (ARF) and acute glomerulonephritis (APSGN), in up to 40% of cases, Group A β-haemolytic streptococcal (GABHS) infections are also implicated as a trigger for Henoch-Schonlein purpura (HSP). A 7-year-old girl with GABHS throat infection who developed HSP, APSGN and rheumatic carditis is reported. She presented with palpable purpura and arthritis in both ankles and later developed carditis characterised by mitral/aortic regurgitation and glomerulonephritis characterised by mixed nephritic/nephrotic syndrome...
February 6, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28161055/maternal-type-1-diabetes-activates-stress-response-in-early-placenta
#16
Martin Gauster, Alejandro Majali-Martinez, Sabine Maninger, Elisabeth Gutschi, Patrick H Greimel, Marina Ivanisevic, Josip Djelmis, Gernot Desoye, Ursula Hiden
INTRODUCTION: Human pregnancy and in particular the first trimester, is a period highly susceptible towards adverse insults such as oxidative stress, which may lead to inadequate embryonic and feto-placental development. Diabetes mellitus is associated with increased oxidative stress caused by hyperglycemia, reactive oxygen species (ROS) production and inflammatory signals. In pregnancy, diabetes elevates the risk for early pregnancy loss, preeclampsia and fetal growth restriction, pathologies that origin from early placental maldevelopment...
February 2017: Placenta
https://www.readbyqxmd.com/read/28157838/purification-and-characterization-of-micrornas-within-middle-ear-fluid-exosomes-implication-in-otitis-media-pathophysiology
#17
Stéphanie Val, Stephanie Jeong, Marian Poley, Anna Krueger, Gustavo Nino, Kristy Brown, Diego Preciado
BACKGROUND: Otitis Media (OM) is characterized by acute infection progressing to chronic middle ear effusion (MEE). Extracellular secretion of microRNAs (miRNAs) in exosomes is a newly discovered mechanism for cells exerting distant cell genetic regulation. Whether MEE contains exosomes with specific miRNAs is unknown. This study aimed to purify and characterize the exosomal and miRNA content of MEE. METHOD: MEEs were subjected to Exoquick exosomal purification and EXOCET exosomal quantification...
February 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28155127/attenuation-of-exercise-induced-heat-shock-protein-72-expression-blunts-improvements-in-whole-body-insulin-resistance-in-rats-with-type-2-diabetes
#18
Takamasa Tsuzuki, Hiroyuki Kobayashi, Toshinori Yoshihara, Ryo Kakigi, Noriko Ichinoseki-Sekine, Hisashi Naito
Heat shock proteins (HSPs) play an important role in insulin resistance and improve the cellular stress response via HSP induction by exercise to treat type 2 diabetes. In this study, the effects of exercise-induced HSP72 expression levels on whole-body insulin resistance in type 2 diabetic rats were investigated. Male 25-week-old Otsuka Long-Evans Tokushima Fatty rats were divided into three groups: sedentary (Sed), trained in a thermal-neutral environment (NTr: 25 °C), and trained in a cold environment (CTr: 4 °C)...
February 2, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28150171/molecular-cloning-and-functional-analysis-of-the-drought-tolerance-gene-mshsp70-from-alfalfa-medicago-sativa-l
#19
Zhenyi Li, Ruicai Long, Tiejun Zhang, Zhen Wang, Fan Zhang, Qingchuan Yang, Junmei Kang, Yan Sun
Heat shock proteins (HSPs) are a ubiquitously expressed class of protective proteins that play a key role in plant response to stressful conditions. This study aimed to characterize and investigate the function of an HSP gene in alfalfa (Medicago sativa). MsHSP70, which contains a 2028-bp open reading frame, was identified through homology cloning. MsHSP70 shares high sequence identity (94.47%) with HSP70 from Medicago truncatula. Expression analysis of MsHSP70 in alfalfa organs revealed a relatively higher expression level in aerial organs such as flowers, stems and leaves than in roots...
February 1, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28143990/microbiota-composition-hsp70-and-caspase-3-expression-as-marker-for-colorectal-cancer-patients-in-aceh-indonesia
#20
Fauzi Yusuf, Syafruddin Ilyas, Harun Al Rasyid Damanik, Fatchiyah Fatchiyah
AIM: to investigate the relationship between microbiota composition with HSP70 and Caspase-3 expressions in colon tissue as an initial study to develop the candidate for early detection of colorectal cancer for Indonesian patients. METHODS: this is a cross-sectional study on 32 patients undergoing colonoscopy; 16 patients of colorectal cancer (CRC) while the other 16 patients are not (colitis and internal hemorrhoid). The composition of microbiota in stool samples was examined using 16S rRNA Denaturing Gradient Gel Electrophoresis (DDGE) while expression of HSP70 was examined by immunohistochemistry and Caspase-3 by using Haematoxylin-Eosin(HE) staining to determine the morphological changes in colon tissue...
October 2016: Acta Medica Indonesiana
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