keyword
https://read.qxmd.com/read/38543274/modulation-of-heat-shock-protein-expression-in-alveolar-adenocarcinoma-cells-through-gold-nanoparticles-and-cisplatin-treatment
#1
JOURNAL ARTICLE
Bashiru Ibrahim, Taiwo Hassan Akere, Swaroop Chakraborty, Eugenia Valsami-Jones, Hanene Ali-Boucetta
Heat-shock proteins (HSPs) are stress-responsive molecules belonging to the family of evolutionary molecular chaperones known to be crucial in many cancer types, including human alveolar adenocarcinoma cells (A549). These proteins are highly overexpressed in cancers to support their ability to accommodate imbalances in cell signalling, DNA alterations, proteins, and energy metabolism associated with oncogenesis. The current study evaluated the effects of gold nanoparticles (AuNPs) combined with cisplatin (CDDP) on molecular chaperone HSPs in A549 cells...
March 11, 2024: Pharmaceutics
https://read.qxmd.com/read/38542474/anti-cancer-mechanisms-of-diarylpentanoid-ms17-1-5-bis-2-hydroxyphenyl-1-4-pentadiene-3-one-in-human-colon-cancer-cells-a-proteomics-approach
#2
JOURNAL ARTICLE
Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Faridah Abas, Iekhsan Othman, Rakesh Naidu
Diarylpentanoids are synthesized to overcome curcumin's poor bioavailability and low stability to show enhanced anti-cancer effects. Little is known about the anti-cancer effects of diarylpentanoid MS17 (1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one) in colon cancer cells. This study aimed to elucidate molecular mechanisms and pathways modulated by MS17 in colon cancer based on proteomic profiling of primary SW480 and metastatic SW620 colon cancer cells. Cytotoxicity and apoptotic effects of MS17 were investigated using MTT assay, morphological studies, and Simple Western analysis...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542407/local-production-of-acute-phase-proteins-a-defense-reaction-of-cancer-cells-to-injury-with-focus-on-fibrinogen
#3
REVIEW
Péter Hamar
This review is intended to demonstrate that the local production of acute phase proteins (termed local acute phase response (lAPR)) and especially fibrin/fibrinogen (FN) is a defense mechanism of cancer cells to therapy, and inhibition of the lAPR can augment the effectiveness of cancer therapy. Previously we detected a lAPR accompanying tumor cell death during the treatment of triple-negative breast cancer (TNBC) with modulated electro-hyperthermia (mEHT) in mice. We observed a similar lAPR in in hypoxic mouse kidneys...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542352/membrane-lipids-and-osmolytes-in-the-response-of-the-acidophilic-basidiomycete-phlebiopsis-gigantea-to-heat-cold-and-osmotic-shocks
#4
JOURNAL ARTICLE
Elena A Ianutsevich, Olga A Danilova, Olga A Grum-Grzhimaylo, Vera M Tereshina
Previously, we found for the first time the participation of osmolytes in adaptation to acidic conditions in three acidophilic fungi. Because trehalose can protect membranes, we hypothesized a relationship between osmolyte and membrane systems in adaptation to stressors. In the mycelium of Phlebiopsis gigantea , the level of osmolytes reaches 8% of the dry mass, while trehalose and arabitol make up 60% and 33% of the sum, respectively. Cold shock does not change the composition of osmolytes, heat shock causes a twofold increase in the trehalose level, and osmotic shock leads to a marked increase in the amount of trehalose and arabitol...
March 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542264/-monot3-subunit-has-important-roles-in-infection-related-development-and-stress-responses-in-magnaporthe-oryzae
#5
JOURNAL ARTICLE
Youngmin Kim, Miju Jo, Sunmin An, Yerim Lee, Eu Ddeum Choi, Min-Hye Jeong, Ki-Tae Kim, Sook-Young Park
The multifunctional carbon catabolite repression negative on TATA-box-less complex (CCR4-NOT) is a multi-subunit complex present in all eukaryotes, including fungi. This complex plays an essential role in gene expression; however, a functional study of the CCR4-NOT complex in the rice blast fungus Magnaporthe oryzae has not been conducted. Seven genes encoding the putative CCR4-NOT complex were identified in the M. oryzae genome. Among these, a homologous gene, MoNOT3 , was overexpressed during appressorium development in a previous study...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542071/prolonged-heat-stress-during-winter-diapause-alters-the-expression-of-stress-response-genes-in-ostrinia-nubilalis-hbn
#6
JOURNAL ARTICLE
Iva Uzelac, Miloš Avramov, Teodora Knežić, Vanja Tatić, Snežana Gošić-Dondo, Željko D Popović
During diapause, a state of temporarily arrested development, insects require low winter temperatures to suppress their metabolism, conserve energy stores and acquire cold hardiness. A warmer winter could, thus, reduce diapause incidence and duration in many species, prematurely deplete their energy reserves and compromise post-diapause fitness. In this study, we investigated the combined effects of thermal stress and the diapause program on the expression of selected genes involved in antioxidant defense and heat shock response in the European corn borer Ostrinia nubilalis ...
March 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541642/unraveling-the-impact-of-dab1-gene-silencing-on-the-expression-of-autophagy-markers-in-lung-development
#7
JOURNAL ARTICLE
Azer Rizikalo, Mirko Maglica, Nela Kelam, Ilija Perutina, Marin Ogorevc, Anita Racetin, Natalija Filipović, Yu Katsuyama, Zdenka Zovko, Josip Mišković, Katarina Vukojević
The purpose of this study was to evaluate the effects of Dab1 gene silencing on the immunoexpression of light chain 3 beta (Lc3b), glucose regulating protein 78 (Grp78), heat shock cognate 71 (Hsc70), mammalian target of rapamycin (mTOR) and lysosomal-associated membrane protein 2A (Lamp2a) in the lung tissue of developing yotari ( Dab1 -/- ) and wild-type (wt) mice. The lung epithelium and mesenchyme of the embryos at gestational days E13.5 and E15.5 were examined using immunofluorescence and semi-quantitative methods...
February 28, 2024: Life
https://read.qxmd.com/read/38540950/exploring-the-mirnas-profile-in-dark-cutting-beef
#8
JOURNAL ARTICLE
Laura González-Blanco, Luis J Royo, Yolanda Diñeiro, Susana García-Torres, Ana Coto-Montes, Verónica Sierra, Mamen Oliván
In an animal production system, different stressors may cause the depletion of muscle glycogen stores, resulting in an elevated pH at 24 h post mortem (pH24 ), which leads to cell metabolism alterations that affect the conversion of muscle into meat, causing meat quality defects, such as dark-cutting beef, also known as dark, firm, and dry (DFD) beef. This process may involve the alteration of small non-coding RNAs (miRNAs), which play critical regulatory roles in cellular processes. Here, we determined whether differential miRNA expression in the Longissimus thoracis et lumborum muscle from the Asturiana de los Valles breed at 24 h post mortem could serve as an early indicator of beef quality defects...
March 21, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38540672/molecular-challenges-and-opportunities-in-climate-change-induced-kidney-diseases
#9
REVIEW
Eder Luna-Cerón, Alfredo Pherez-Farah, Indumathi Krishnan-Sivadoss, Carlos Enrique Guerrero-Beltrán
As temperatures continue to modify due to weather changes, more regions are being exposed to extreme heat and cold. Physiological distress due to low and high temperatures can affect the heart, blood vessels, liver, and especially, the kidneys. Dehydration causes impaired cell function and heat itself triggers cellular stress. The decline in circulating plasma volume by sweat, which stresses the renal and cardiovascular systems, has been related to some molecules that are crucial players in preventing or provoking cellular damage...
February 21, 2024: Biomolecules
https://read.qxmd.com/read/38540443/mining-heat-resistant-key-genes-of-peony-based-on-weighted-gene-co-expression-network-analysis
#10
JOURNAL ARTICLE
Xingyu Yang, Yu Huang, Yiping Yao, Wenxuan Bu, Minhuan Zhang, Tangchun Zheng, Xiaoning Luo, Zheng Wang, Weiqun Lei, Jianing Tian, Lujie Chen, Liping Qin
The RNA-Seq and gene expression data of mature leaves under high temperature stress of Paeonia suffruticosa 'Hu Hong' were used to explore the key genes of heat tolerance of peony. The weighted gene co-expression network analysis (WGCNA) method was used to construct the network, and the main modules and core genes of co-expression were screened according to the results of gene expression and module function enrichment analysis. According to the correlation of gene expression, the network was divided into 19 modules...
March 21, 2024: Genes
https://read.qxmd.com/read/38540377/comprehensive-assessment-of-reference-gene-expression-within-the-whitefly-dialeurodes-citri-using-rt-qpcr
#11
JOURNAL ARTICLE
Weizhen Kong, Xiaolu Lv, Xiaotong Ran, Marguerite Mukangango, Bugenimana Eric Derrick, Baoli Qiu, Changfei Guo
The citrus whitefly, Dialeurodes citri , is a destructive pest that infests citrus plants. It is a major vector in transmitting plant viruses such as citrus yellow vein clearing virus (CYVCV), which has caused severe economic losses worldwide, and therefore efficient control of this pest is economically important. However, the scope of genetic studies primarily focused on D. citri is restricted, something that has potentially limited further study of efficient control options. To explore the functionalities of D...
February 28, 2024: Genes
https://read.qxmd.com/read/38540349/genome-wide-identification-and-transcriptome-analysis-of-the-hsp70-gene-family-in-monodonta-labio-reveals-its-role-in-response-to-nanoplastics-stress
#12
JOURNAL ARTICLE
Jingjing He, Xiaolu Han, Shaolei Sun, Shihuai Jin, Mengyuan Liu, Zhiqiang Han
For marine invertebrates, the disruption of organismal physiology and behavior by nanoplastics (NPs) has been extensively reported. Heat shock proteins (Hsps) are important for redundant protein breakdown, environmental changes, and intracellular protein transport. An exhaustive identification of Hsp70 genes and an experiment where different concentrations of NPs were stressed were performed to study how Hsp70 genes respond to NPs stress in Monodonta labio . Our results identified 15 members of Hsp70 within the genome of M...
February 25, 2024: Genes
https://read.qxmd.com/read/38539955/evidence-for-beneficial-physiological-responses-of-the-land-snail-cornu-aspersum-to-probiotics-lactobacillus-plantarum-dietary-intervention
#13
JOURNAL ARTICLE
Efstratios Efstratiou, Konstantinos Feidantsis, Vasiliki Makri, Alexandra Staikou, Ioannis A Giantsis
A large variety of microorganisms ingested with food constitute animals' intestinal microflora, enhancing and maintaining the homeostasis of the host. Rations enriched with probiotics are a method recommended to prevent undesirable conditions. To date, research has been limited to farmed animals and reared fish, creating a knowledge gap concerning the effect of probiotics on the growth rate, physiological responses, and energy metabolism of invertebrates such as the land snail Cornu aspersum . Herein, juvenile snails (26...
March 11, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539491/application-of-nanoparticles-for-magnetic-hyperthermia-for-cancer-treatment-the-current-state-of-knowledge
#14
REVIEW
Marzena Szwed, Agnieszka Marczak
Hyperthermia (HT) is an anti-cancer therapy commonly used with radio and chemotherapies based on applying heat (39-45 °C) to inhibit tumor growth. However, controlling heat towards tumors and not normal tissues is challenging. Therefore, nanoparticles (NPs) are used in HT to apply heat only to tumor tissues to induce DNA damage and the expression of heat shock proteins, which eventually result in apoptosis. The aim of this review article is to summarize recent advancements in HT with the use of magnetic NPs to locally increase temperature and promote cell death...
March 14, 2024: Cancers
https://read.qxmd.com/read/38538975/novel-methyltransferase-g9a-inhibitor-induces-ferroptosis-in-multiple-myeloma-through-nrf2-ho-1-pathway
#15
JOURNAL ARTICLE
Yu Zhang, Xiaoshun Wang, Xiaoqi Li, Xingfang Xiong, Renyu Xue, Lanlan Zang, Zhiqiang Wang, Lijuan Wang
Multiple myeloma (MM) is a common malignant hematologic neoplasm, and the involvement of epigenetic modifications in its development and drug resistance has received widespread attention. Ferroptosis, a new ferroptosis-dependent programmed death mode, is closely associated with the development of MM. The novel methyltransferase inhibitor DCG066 has higher cell activity, but its mechanism of action in MM has not been clarified. Here, we found that DCG066 (5µM) inhibited the proliferation and induced ferroptosis in MM cells; the intracellular levels of ROS, iron, and MDA were significantly elevated, and the level of GSH was reduced after the treatment of DCG066; The protein expression levels of SLC7A11, GPX4, Nrf2 and HO-1 were significantly reduced, and these phenomena could be reversed by ferroptosis inhibitor Ferrostatin-1 (Fer-1) and Nrf2 activator Tert-butyl hydroquinone (TBHQ)...
March 27, 2024: Annals of Hematology
https://read.qxmd.com/read/38538936/the-complex-circumstellar-environment-of-supernova-2023ixf
#16
JOURNAL ARTICLE
E A Zimmerman, I Irani, P Chen, A Gal-Yam, S Schulze, D A Perley, J Sollerman, A V Filippenko, T Shenar, O Yaron, S Shahaf, R J Bruch, E O Ofek, A De Cia, T G Brink, Y Yang, S S Vasylyev, S Ben Ami, M Aubert, A Badash, J S Bloom, P J Brown, K De, G Dimitriadis, C Fransson, C Fremling, K Hinds, A Horesh, J P Johansson, M M Kasliwal, S R Kulkarni, D Kushnir, C Martin, M Matuzewski, R C McGurk, A A Miller, J Morag, J D Neil, P E Nugent, R S Post, N Z Prusinski, Y Qin, A Raichoor, R Riddle, M Rowe, B Rusholme, I Sfaradi, K M Sjoberg, M Soumagnac, R D Stein, N L Strotjohann, J H Terwel, T Wasserman, J Wise, A Wold, L Yan, K Zhang
The early evolution of a supernova (SN) can reveal information about the environment and the progenitor star. When a star explodes in vacuum, the first photons to escape from its surface appear as a brief, hours-long shock-breakout flare1,2 , followed by a cooling phase of emission. However, for stars exploding within a distribution of dense, optically thick circumstellar material (CSM), the first photons escape from the material beyond the stellar edge and the duration of the initial flare can extend to several days, during which the escaping emission indicates photospheric heating3 ...
March 2024: Nature
https://read.qxmd.com/read/38537598/ph-dependence-of-hsf1-trimerization-is-shaped-by-intramolecular-interactions
#17
JOURNAL ARTICLE
Bo-Hee Choi, Chang-Ju Lee, Tae Hwan Kim, David Nahm-Joon Kim, Young-Shang Park, Jeong-Mo Choi, Jang-Su Park
Heat shock factor 1 (HSF1) primarily regulates various cellular stress responses. Previous studies have shown that low pH within the physiological range directly activates HSF1 function in vitro. However, the detailed molecular mechanisms remain unclear. This study proposes a molecular mechanism based on the trimerization behavior of HSF1 at different pH values. Extensive mutagenesis of human and goldfish HSF1 revealed that the optimal pH for trimerization depended on the identity of residue 103. In particular, when residue 103 was occupied by tyrosine, a significant increase in the optimal pH was observed, regardless of the rest of the sequence...
March 25, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38537587/ti-2-c-3-mxene-based-nanocomposite-as-an-intelligent-nanoplatform-for-efficient-mild-hyperthermia-treatment
#18
JOURNAL ARTICLE
Bai Li, Gege Fu, Chao Liu, Yang Lu, Yingqian Mi, Dongmei Yan, Jiahang Wu, Xinhua Dai, Dianbo Cao, Wanchao Liu, Xiaomin Liu
Photothermal therapy (PTT) has attracted much attention due to its less invasive, controllable and highly effective nature. However, PTT also suffers from intrinsic cancer resistance mediated by cell survival pathways. These survival pathways are regulated by a variety of proteins, among which heat shock protein (HSP) triggers thermotolerance and protects tumor cells from hyperthermia-induced apoptosis. Confronted by this challenge, we propose and validate here a novel MXene-based HSP-inhibited mild photothermal platform, which significantly enhances the sensitivity of tumor cells to heat-induced stress and thus improves the PPT efficacy...
March 22, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38537528/distinct-induction-pathways-of-heat-shock-protein-27-in-human-keratinocytes-heat-stimulation-or-capsaicin-through-phosphorylation-of-heat-shock-factor-1%C3%A2-at-serine-326-and-or-suppression-of-%C3%AE-np63
#19
JOURNAL ARTICLE
Terufumi Kubo, Kenta Sasaki, Sayuri Sato, Tomoyuki Minowa, Tokimasa Hida, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Hisashi Uhara, Toshihiko Torigoe
Epidermal keratinocytes, forming the outermost layer of the human body, serve as a crucial barrier against diverse external stressors such as ultraviolet radiation. Proper keratinocyte differentiation and effective responses to external stimuli are pivotal for maintaining barrier integrity. Heat is one such stimulus that triggers the synthesis of heat shock proteins (HSPs) when cells are exposed to temperatures above 42 °C. Additionally, activation of the transient receptor potential cation channel subfamily V member 1 (TRPV1) occurs at 42 °C...
March 22, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38537450/novel-oridonin-analog-cyd0682-inhibits-hepatic-stellate-cell-activation-via-the-heat-shock-protein-90-dependent-stat3-pathway
#20
JOURNAL ARTICLE
Jana E Dejesus, Xiaofu Wang, Yanping Gu, Jia Zhou, Ravi S Radhakrishnan
INTRODUCTION: Activated hepatic stellate cells (HSCs) are the primary effector cells in hepatic fibrosis, over depositing extracellular matrix (ECM) proteins. Our previous work found oridonin analog CYD0682 attenuates proliferation, Transforming Growth Factor β (TGFβ)-induced signaling, and ECM production in immortalized HSCs. The underlying mechanism behind these reductions is unclear. The Signal Transduction and Activator of Transcription 3 (STAT3) pathway plays a central role in HSC activation and has been found to be overexpressed in models of hepatic injury...
March 26, 2024: Journal of Surgical Research
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