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https://www.readbyqxmd.com/read/29458175/maintenance-of-hematopoietic-stem-and-progenitor-cells-in-fetal-intra-aortic-hematopoietic-clusters-by-the-sox17-notch1-hes1-axis
#1
Kiyoka Saito, Ikuo Nobuhisa, Kaho Harada, Satomi Takahashi, Maha Anani, Heiko Lickert, Masami Kanai-Azuma, Yoshiakira Kanai, Tetsuya Taga
The aorta-gonad-mesonephros region, from which definitive hematopoiesis first arises in midgestation mouse embryos, has intra-aortic hematopoietic clusters (IAHCs) containing hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). We previously reported expression of the transcription factor Sox17 in IAHCs, and overexpression of Sox17 in CD45low c-KIThigh cells comprising IAHCs maintains the formation of cell clusters and their multipotency in vitro over multiple passages. Here, we demonstrate the importance of NOTCH1 in IAHC formation and maintenance of the HSC/HPC phenotype...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29457623/severe-aortic-regurgitation-caused-by-unicuspid-aortic-valve
#2
Gabriela Dostálová, Zuzana Hlubocká, Jaroslav Hlubocký, Tomáš Paleček, Aleš Linhart
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29457560/prophylactic-intra-aortic-balloon-counterpulsation-before-surgical-myocardial-revascularization-in-patients-with-acute-myocardial-infarction
#3
Philippe Grieshaber, Tobias Schneider, Lukas Oster, Coskun Orhan, Peter Roth, Bernd Niemann, Andreas Böning
INTRODUCTION: Prophylactic intra-aortic balloon counterpulsation (pIABC) is recommended for high-risk patients undergoing coronary artery bypass grafting (CABG) surgery. Criteria for high-risk patients benefiting from pIABC are unclear. This study aimed to specifically describe the effect of pIABC on outcomes of patients with acute myocardial infarction (AMI) undergoing CABG. METHODS: In 178 of 484 AMI patients (non-ST-segment elevation myocardial infarction [NSTEMI] or ST-segment elevation myocardial infarction [STEMI] ≤5 days before surgery) without cardiogenic shock who underwent CABG between 2008 and 2013, pIABC was initiated preoperatively...
February 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29457360/neglected-areas-on-thorax-computed-tomography-evaluation-in-patients-with-chronic-obstructive-pulmonary-disease-paravertebral-muscles-and-para-aortic-adipose-tissue
#4
Mustafa Resorlu, Ozan Karatag, Canan A Toprak, Muhsin O Ozturk
INTRODUCTION: This study, investigated the para-aortic adipose tissue cross-sectional area, a novel predictor of cardiovascular diseases and degenerative changes in the paravertebral muscles, in patients with chronic obstructive pulmonary disease (COPD). METHOD: One hundred cases diagnosed as COPD and 50 healthy individuals with similar demographic characteristics were evaluated. Para-aortic adipose tissue cross-sectional area (mm2 ), subcutaneous adipose tissue thickness (mm), paravertebral muscle area (mm2 ) and fat deposition in muscle tissue were assessed radiologically...
February 18, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29457351/24-hour-aortic-blood-pressure-variability-showed-a-stronger-association-with-carotid-damage-than-24-hour-brachial-blood-pressure-variability-the-safar-study
#5
Shikai Yu, Chen Chi, Athanase D Protogerou, Michel E Safar, Jacques Blacher, Antonis A Argyris, Efthimia G Nasothimiou, Petros P Sfikakis, Theodore G Papaioannou, Henry Xu, Yi Zhang, Yawei Xu
We aim to compare 24-hour aortic blood pressure variability (BPV) with brachial BPV in relation to carotid damage as estimated by carotid intima-media thickness (CIMT) and cross-sectional area (CCSA). Four hundred and forty five individuals received brachial and aortic 24-hour ambulatory BP monitoring with a validated device (Mobil-O-Graph). Systolic BPV was estimated by average real variability (ARV) and time-weighted standard deviation (wSD). In multiple logistic regression analysis, CIMT > 900 μm was significantly and independently associated with aortic ARV (OR = 1...
February 19, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29457265/the-role-of-type-2-diabetes-mellitus-on-hypertensive-related-aortic-stiffness
#6
Edoardo Sciatti, Enrico Vizzardi, Assunta Castiello, Francesca Valentini, Ivano Bonadei, Sandro Gelsomino, Roberto Lorusso, Marco Metra
BACKGROUND: Hypertension is strongly related to arterial stiffness in a cause-effect fashion. Diabetes mellitus is also thought to determine vascular damage, mostly by means of advanced glycosylation end-products (AGEs). Aim of our study was to study the role of type 2 diabetes mellitus (T2DM) as regard ascending aortic elastic properties in hypertensive patients. METHODS: We prospectively enrolled outpatients with hypertension (n = 99) and type 2 diabetes mellitus plus hypertension (n = 42) without cardiovascular events...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29457124/dilated-aortic-root-influences-pulmonary-artery-catheter-placement-in-anesthetized-patients
#7
Yuka Miyata, Tsutomu Wada, Tomohiko Hayasaka, Yukio Hayashi
Purpose: The placement of a pulmonary artery catheter sometimes needs long time by observing the pressure wave, and several factors have been reported to hinder the placement. In the present study, we examined whether enlargement of the aortic root is associated with longer time for the placement. Method: We examined the time required for the catheter placement. The catheter placement time was defined as the duration of time required for the catheter to float from the CVP position to the pulmonary artery...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29457116/a-spinal-cord-infarction-that-occurred-after-laparoscopic-gastrectomy-performed-under-general-anesthesia-and-epidural-analgesia
#8
Kei Houri, Shinichi Hamasaki, Takatoshi Tsujimoto, Tomohisa Uchida, Tatsushige Iwamoto, Toru Shirai, Shinichi Nakao
Background: Spinal cord infarction (SCI) after epidural anesthesia is quite rare. Although most cases of perioperative SCI are associated with aortic, cardiac, or spinal surgery, and/or abnormal preoperative conditions, such as spinal stenosis or hypercoagulopathy, intraoperative events, such as severe hypotension or epidural puncture and catheterization, can be contributory factors. Case presentation: A 52-year-old male was underwent laparoscopic gastrectomy. Before induction of general anesthesia, an epidural catheter was placed without any problems...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29456878/non-destructive-two-photon-excited-fluorescence-imaging-identifies-early-nodules-in-calcific-aortic-valve-disease
#9
Lauren M Baugh, Zhiyi Liu, Kyle P Quinn, Sam Osseiran, Conor L Evans, Gordon S Huggins, Philip W Hinds, Lauren D Black, Irene Georgakoudi
Calcifications occur during the development of healthy bone, and at the onset of calcific aortic-valve disease (CAVD) and many other pathologies. Although the mechanisms regulating early calcium deposition are not fully understood, they may provide targets for new treatments and for early interventions. Here, we show that two-photon excited fluorescence (TPEF) can provide quantitative and sensitive readouts of calcific nodule formation, in particular in the context of CAVD. Specifically, by means of the decomposition of TPEF spectral images from excised human CAVD valves and from rat bone prior to and following demineralization, as well as from calcific nodules formed within engineered gels, we identified an endogenous fluorophore that correlates with the level of mineralization in the samples...
November 2017: Nature Biomedical Engineering
https://www.readbyqxmd.com/read/29456717/naringin-ameliorates-endothelial-dysfunction-in-fructose-fed-rats
#10
Wachirawadee Malakul, Sirinat Pengnet, Chanon Kumchoom, Sakara Tunsophon
High fructose consumption is associated with metabolic disorders including hyperglycemia and dyslipidemia, in addition to endothelial dysfunction. Naringin, a flavonoid present in citrus fruit, has been reported to exhibit lipid lowering, antioxidant, and cardiovascular protective properties. Therefore, the present study investigated the effect of naringin on fructose-induced endothelial dysfunction in rats and its underlying mechanisms. Male Sprague-Dawley rats were given 10% fructose in drinking water for 12 weeks, whereas control rats were fed drinking water alone...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456054/the-relationship-between-serum-interleukin-1%C3%AE-and-asymptomatic-infrarenal-abdominal-aortic-aneurysm-size-morphology-and-growth-rates
#11
Mehtab Ahmad, Sahithi Kuravi, James Hodson, G Ed Rainger, Gerard B Nash, Rajiv K Vohra, Andrew W Bradbury
OBJECTIVE/BACKGROUND: In a pilot study, a relationship between abdominal aortic aneurysm (AAA) diameter and serum interleukin (IL)-1α levels was reported, and that endothelial cell (EC) activation in vitro in response to serum from patients with AAA was blocked by anti-IL-1α antibodies. The aim of the present study was to further investigate the relationship between serum IL-1α and asymptomatic infrarenal AAA size, morphology, and growth rates. METHODS: Serum IL-1α was measured using enzyme linked immunosorbent assay in 101 patients with asymptomatic, infrarenal AAA and related to aneurysm size, morphology, and growth rates...
February 16, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29456049/six-month-outcomes-after-high-risk-coronary-artery-bypass-graft-surgery-and-preoperative-intra-aortic-balloon-counterpulsation-use-an-inception-cohort-study
#12
Edward Litton, Frances Bass, Anthony Delaney, Graham Hillis, Silvana Marasco, Shay McGuinness, Paul S Myles, Christopher M Reid, Julian A Smith
OBJECTIVE: To inform the design of a pivotal randomized controlled trial of prophylactic intra-aortic balloon counterpulsation (IABC) in patients undergoing coronary artery bypass graft (CABG) at high risk of postoperative low cardiac output syndrome (LCOS). DESIGN: Inception cohort study. SETTING: A total of 13 established cardiac centers in Australia, Canada, New Zealand, and the United Kingdom. PARTICIPANTS: Adult patients were eligible for inclusion if they were listed for CABG surgery and had 2 or more LCOS risk factors (low ejection fraction, severe left main coronary artery disease, redo sternotomy, unstable angina)...
January 5, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29455964/polytetrafluoroethylene-conduits-versus-homografts-for-right-ventricular-outflow-tract-reconstruction-in-infants-and-young-children-an-institutional-experience
#13
Christopher W Mercer, Shawn C West, Mahesh S Sharma, Masahiro Yoshida, Victor O Morell
OBJECTIVE: Our institution uses a valved polytetrafluoroethylene conduit as an alternative to homografts. The objective of this study was to investigate the performance of bicuspid valved polytetrafluoroethylene conduits used for right ventricular outflow tract reconstruction in children aged less than 2 years and to evaluate risk factors for earlier conduit explant. METHODS: We performed an Institutional Review Board-approved retrospective chart review of all patients aged less than 2 years who underwent surgical right ventricular outflow tract reconstruction with a bicuspid valved polytetrafluoroethylene conduit or homograft conduit from July 2004 to December 2014...
January 31, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29455849/relationship-between-proximal-aorta-morphology-and-progression-rate-of-aortic-stenosis
#14
Romain Capoulade, Jonathan G Teoh, Philipp E Bartko, Eliza Teo, Jan-Erik Scholtz, Lionel Tastet, Mylene Shen, Christos G Mihos, Yong H Park, Julio Garcia, Eric Larose, Eric M Isselbacher, Thoralf M Sundt, Thomas E MacGillivray, Serguei Melnitchouk, Brian B Ghoshhajra, Philippe Pibarot, Judy Hung
BACKGROUND: The aim of this study was to examine the association between abnormal morphology of the proximal aorta and aortic stenosis (AS) progression rate. The main hypothesis was that morphologic changes of the proximal aorta, such as effacement of the sinotubular junction (STJ), result in increased biomechanical stresses and contribute to calcification and progression of AS. METHODS: Between 2010 and 2012, 426 patients with mild to moderate AS were included in this study...
February 16, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29455830/transaortic-alfieri-edge-to-edge-repair-for-functional-mitral-regurgitation
#15
Ken-Ichi Imasaka, Eiki Tayama, Shigeki Morita, Ryohei Toriya, Yukihiro Tomita
There is controversy about handling functional mitral regurgitation in patients undergoing aortic valve or proximal aortic operations. We describe a transaortic Alfieri edge-to-edge repair for functional mitral regurgitation that reduces operative excessive invasion and prolonged cardiopulmonary bypass time. Between May 2013 and December 2016, 10 patients underwent transaortic Alfieri edge-to-edge mitral repair. There were no operative deaths. The severity of mitral regurgitation immediately after the operation by transesophageal echocardiography was none or trivial in all patients...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29455820/ductus-aneurysm-ruptured-into-the-esophagus-with-massive-bleeding
#16
Takeshi Soeda, Mai Sakashita, Takamitsu Hamada, Yuhei Saito, Yasuhito Kitakado, Nobuo Morioka
We report a patient with life-threatening hematemesis caused by the rupture of a ductus aneurysm into the esophagus, which was successfully treated by coil embolism for the esophageal fistula through the aorta and subsequent thoracic endovascular aortic replacement. Second-stage therapy was performed surgically after proactive antibiotic treatment and in consideration of the patient's improved general condition. This included debridement with drainage, aortic encasement with remnant aneurysmal wall, omentopexy, and jejunostomy...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29455818/mitral-regurgitation-exacerbation-due-to-sutureless-aortic-valve-replacement
#17
Timothy Lee, Alexander J C Mittnacht, Shinobu Itagaki, Allan Stewart
Sutureless aortic valves are increasingly used for aortic valve replacement (AVR) with excellent outcomes. Implantation requires device expansion in a subannular position within the native aortic root. We report a patient with severe aortic stenosis who received a Perceval sutureless AVR (LivaNova, London, United Kingdom), resulting in a competent prosthesis with an absence of paravalvular leak and aortic regurgitation. However, this implantation resulted in the exacerbation of mitral regurgitation. The sutureless valve required explantation, and a traditional sutured valve was subsequently implanted, which returned the mitral regurgitation to baseline...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29455804/step-by-step-aortic-valve-replacement-with-a-new-rapid-deployment-valve
#18
Kevin D Accola, W Randolph Chitwood, Mubashir A Mumtaz, Glenn R Barnhart
PURPOSE: Rapid deployment/sutureless aortic valve replacement is aimed at minimizing the invasiveness of surgical aortic valve replacement. We describe the implantation techniques of a new rapid deployment aortic valve, focusing on its unique and challenging features. DESCRIPTION: The EDWARDS INTUITY Elite aortic valve (Edwards Lifesciences, Irvine, CA) represents a hybrid between the surgical PERIMOUNT Magna Ease (Edwards Lifesciences) pericardial valve, but with advanced features of the percutaneous SAPIEN valve system (Edwards Lifesciences)...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29455791/criss-cross-heart-transthoracic-echocardiographic-features
#19
Devi Manuel, Gopal Ghosh, George Joseph, Anandaroop Lahiri, Paul V George
OBJECTIVE: To study the echocardiographic features of criss-cross heart (CCH), a congenital cardiac anomaly characterized by crossed ventricular inflow streams, in Indian patients. METHODS: In this retrospective observational study, all pediatric echocardiograms performed in a single tertiary care institution in South India over a three-year period were scrutinized for a diagnosis of CCH. Demographic, clinical and echocardiographic data were collected from patients' medical records and echocardiographic database...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455786/examination-of-the-appropriate-timing-of-reperfusion-therapy-for-recent-myocardial-infarction-a-japanese-single-center-retrospective-study
#20
Yukio Mizuguchi, Hiroki Shibutani, Sho Hashimoto, Takeshi Yamada, Norimasa Taniguchi, Shunsuke Nakajima, Tetsuya Hata, Akihiko Takahashi
BACKGROUND: The various guidelines clearly mention the treatment strategies for in patient of acute myocardial infarction (MI) presenting more than 24h from symptom onset (recent myocardial infarction, RMI). However, the appropriate timing of reperfusion for RMI is unclear. METHODS: We retrospectively evaluated 525 consecutive MI patients who underwent percutaneous coronary intervention (PCI) in our hospital between January 2008 and December 2012. RESULTS: Sixty RMI patients were more frequently associated with cardiac complications such as myocardial rupture (3...
January 2018: Indian Heart Journal
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