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https://www.readbyqxmd.com/read/28107707/uremia-modulates-the-phenotype-of-aortic-smooth-muscle-cells
#1
Marie Madsen, Annemarie Aarup, Sebastian Albinsson, Karsten Hartvigsen, Charlotte M Sørensen, Karolina Turczynska, Lars B Nielsen, Tanja Xenia Pedersen
BACKGROUND AND AIMS: Chronic kidney disease leads to uremia and markedly accelerates atherosclerosis. Phenotypic modulation of smooth muscle cells (SMCs) in the arterial media plays a key role in accelerating atherogenesis. The aim of this study was to investigate whether uremia per se modulates the phenotype of aortic SMCs in vivo. METHODS: Moderate uremia was induced by 5/6 nephrectomy in apolipoprotein E knockout (ApoE(-/-)) and wildtype C57Bl/6 mice. Plasma analysis, gene expression, histology, and myography were used to determine uremia-mediated changes in the arterial wall...
December 23, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28107261/management-of-para-aortic-lymph-node-disease-in-patients-with-cervical-cancer-what-is-the-best-approach
#2
Marcelo Vailati Negrão, Julianne Maria da Silva Lima, Samantha Cabral Severino Silva, Maria Del Pilar Estevez Diz, Vanessa da Costa Miranda
Cervical cancer remains a prevalent and deadly disease in low-income countries, especially among young and otherwise healthy women. Multimodality treatment has led to a significant improvement in outcomes for patients with locally advanced disease, and this is mainly because of the incorporation of platinum-based chemoradiotherapy in current treatment protocols. However, locally advanced tumors are associated with a greater risk for para-aortic lymph node (PALN) involvement, which is an important adverse prognostic factor...
January 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28106967/mitral-valve-repair-and-aortic-valve-replacement-with-sutureless-prosthesis-implantation-through-a-right-minithoracotomy
#3
Antonio Lio, Antonio Miceli, Matteo Ferrarini, Mattia Glauber
Little experience exists in minimally invasive treatment of double-valve disease. In this report, we present a minimally invasive approach for mitral and aortic valve disease through a minithoracotomy in the 3rd intercostal space with a sutureless aortic prosthesis implantation.
December 14, 2016: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/28106963/wire-skills-for-the-surgeon-femoral-access-safety-net-and-vascular-closure-devices-in-transfemoral-transcatheter-aortic-valve-implantation-procedures
#4
Simon Sndermann, Axel Unbehaun, Alexander Meyer, Volkmar Falk, Jrg Kempfert
Transfemoral transcatheter aortic valve implantation procedures are widely used to treat patients with aortic stenosis and high surgical risk. Major vascular complications are common and are associated with higher mortality rates. We describe the use of vascular access site closure systems and a safety net to prevent and handle these complications.
December 14, 2016: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/28106684/sudden-death-due-to-unusual-complication-of-takayasu-arteritis-an-autopsy-case
#5
Maher Jedidi, Youssef Chkirbene, Nihed Abdessayed, Tasnim Masmoudi, Mohamed Mahjoub, Souheil Mlayeh, Mohamed Ben Dhiab, Mohamed Kamel Souguir, Mohamed Taher Yacoubi
Takayasu arteritis is an uncommon inflammatory disease with usually a good prognosis. However, sometimes, the evolution can be fatal essentially by a coronary arteries involvement. We present a case of a 19-year-old woman who died suddenly from cardiogenic shock complicating an unknown Takayasu arteritis.At the autopsy, the aorta showed a significant thickening of the wall. The coronary arteries were slightly thickened and did not show any occlusion. Microscopic examination of the aorta showed an abundant granulomatous and a lymphoplasmacytic infiltrate...
January 18, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28106155/secreted-mir-27a-induced-by-cyclic-stretch-modulates-the-proliferation-of-endothelial-cells-in-hypertension-via-grk6
#6
Lu Wang, Han Bao, Kai-Xuan Wang, Ping Zhang, Qing-Ping Yao, Xiao-Hu Chen, Kai Huang, Ying-Xin Qi, Zong-Lai Jiang
Abnormal proliferation of endothelial cells (ECs) is important in vascular remodeling during hypertension, but the mechanisms are still unclear. In hypertensive rats caused by abdominal aortic coarctation, the expression of G-protein-coupled receptor kinase 6 (GRK6) in ECs at common carotid artery was repressed in vivo, and EC proliferation was increased. 15% cyclic stretch in vitro, which mimics the pathologically increased stretch in hypertension, repressed EC GRK6 expression via paracrine control by vascular smooth muscle cells (VSMCs)...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28106028/case-image-severe-aortic-regurgitation-due-to-quadricuspid-aortic-valve-in-a-young-patient
#7
Mehmet Demir, Ahmet Yıldırım, Burcu Çavlan
No abstract text is available yet for this article.
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28106026/successful-simultaneous-ipsilateral-stenting-of-common-iliac-artery-stenosis-and-transfemoral-aortic-valve-replacement
#8
Abdullah Nabi Aslan, Hacı Ahmet Kasapkara, Serkan Sivri, Murat Can Güney, Engin Bozkurt
Transcatheter aortic valve replacement (TAVR) was designed to treat elderly patients with severe aortic stenosis at high risk for surgery, and is most commonly performed with retrograde approach through femoral arteries. However, in up to 30% of cases, it is either not possible to use this access route or it is considered to have high risk of vascular injury. Alternative approaches have been described for patients with no suitable femoral access: trans-subclavian, transaortic, or direct aortic access; however, since the introduction of new valves deployed with low-profile delivery systems, another alternative transcatheter approach has been discovered...
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28106022/complicated-left-sided-infective-endocarditis-in-chronic-hemodialysis-patients-a-case-report
#9
Öykü Gülmez, Mehtap Aydın
Infective endocarditis (IE) is a serious infectious condition with high morbidity and mortality in patients with end-stage renal disease (ESRD). It has been particularly associated with recurrent bacteremia due to vascular access via lumen catheters. The most common pathogen is Staphylococcus (S.) aureus, and most affected valve is mitral valve, which frequently calcified. Two patients with ESRD who received hemodialysis treatment via tunneled catheters, aged 56 and 88 years, were admitted with fever and high troponin level...
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28106001/impact-of-femoral-artery-puncture-using-digital-subtraction-angiography-and-road-mapping-on-vascular-and-bleeding-complications-after-transfemoral-transcatheter-aortic-valve-implantation
#10
Mohamed El-Mawardy, Bettina Schwarz, Martin Landt, Dmitriy Sulimov, Julia Kebernik, Abdelhakim Allali, Bjoern Becker, Ralph Toelg, Gert Richardt, Mohamed Abdel-Wahab
AIMS: The use of large-diameter sheaths carries the risk of significant vascular and bleeding complications after transfemoral transcatheter aortic valve implantation (TAVI). In this analysis, we sought to assess the impact of a modified femoral artery puncture technique using digital subtraction angiography (DSA) and road mapping during transfemoral TAVI on periprocedural vascular and bleeding events. METHODS AND RESULTS: This is a retrospective analysis of transfemoral TAVI patients included in a prospective institutional database...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28106000/left-bundle-branch-block-after-sutureless-transcatheter-and-stented-biological-aortic-valve-replacement-for-aortic-stenosis
#11
Madelien V Regeer, Lisanne R Merkestein, Arend de Weger, Vasileios Kamperidis, Frank van der Kley, Philippe J van Rosendael, Nina Ajmone Marsan, Robert J M Klautz, Martin J Schalij, Jeroen J Bax, Victoria Delgado
AIMS: Conventional aortic valve replacement (AVR), sutureless AVR (su-AVR) and transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) are associated with conduction abnormalities. The aim of the present study was to assess the incidence of left bundle branch block (LBBB) after su-AVR and TAVI, in comparison to conventional AVR. METHODS AND RESULTS: A total of 501 patients (mean age 74±8 years, 53% male) without preoperative cardiac conduction disturbances who underwent AVR or TAVI were included in the study...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28105999/transcatheter-aortic-valve-replacement-with-the-portico-valve-one-year-results-of-the-early-canadian-experience
#12
Gidon Y Perlman, Anson Cheung, Eric Dumont, Dion Stub, Danny Dvir, Maria Del Trigo, Marc Pelletier, Sami Alnasser, Jian Ye, David Wood, Christopher Thompson, Philipp Blanke, Jonathon Leipsic, Michael A Seidman, Heather LeBlanc, Christopher E Buller, Josep Rodés-Cabau, John G Webb
AIMS: The aim of this study was to examine the short- and medium-term outcomes of transcatheter aortic valve replacement (TAVR) with the self-expanding and repositionable Portico valve (St. Jude Medical, St. Paul, MN, USA). METHODS AND RESULTS: A total of 57 patients underwent TAVR with the Portico valve between March 2012 and August 2014, representing the first-in-human experience and the entire early experience in Canada. Patients were followed up at 30 days and one year with repeat echocardiography and clinical review...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28105998/simultaneous-transfemoral-aortic-and-transseptal-mitral-valve-replacement-utilising-sapien-3-valves-in-native-aortic-and-mitral-valves
#13
Mohammad Bashir, Gardar Sigurdsson, Phillip A Horwitz, Firas Zahr
AIMS: Concomitant severe calcific aortic and mitral stenosis is a relatively uncommon but very challenging valvular heart disease to manage. We sought to evaluate the feasibility of a fully percutaneous approach to replace both stenotic native mitral and aortic valves using SAPIEN 3 valves. METHODS AND RESULTS: An 87-year-old woman with chronic kidney disease stage 3, pul-monary hypertension, chronic obstructive pulmonary disease, a permanent pacemaker, and atrial fibrillation was referred with Class III heart failure symptoms...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28105997/first-successful-transcatheter-double-valve-replacement-from-a-transapical-access-and-nine-month-follow-up
#14
Robert Bauernschmitt, Stefan Bauer, Christian Liewald, Ramiz Emini, Wolfgang Oechsner, Meinrad Beer, Ralf Sodian, Andreas Liebold
AIMS: While TAVI is the treatment of choice in patients with aortic stenosis considered inoperable or at high risk, interventional replacement of the mitral valve is still in the preclinical or early clinical phase. Our aim was to report on the first transcatheter double valve replacement into native valves from a transapical access. METHODS AND RESULTS: A 67-year-old, highly symptomatic female patient considered inoperable due to severe calcification of the mitral annulus and comorbidities was scheduled for transcatheter double valve replacement by the local Heart Team...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28105789/pdgfra-amplification-in-multiple-skin-lesions-of-undifferentiated-pleomorphic-sarcoma-ups-a-clue-for-intimal-sarcoma-metastases
#15
A Osio, M-D Vignon-Pennamen, F Pedeutour, C Le Maignan, F Koskas, C Lebbé, A Janin, M Battistella
A 62-year-old HIV-positive man was admitted for multiple cutaneous and subcutaneous nodules on his lower limbs, corresponding to an undifferentiated proliferation of spindle and pleomorphic cells, with irregular nuclei and numerous mitoses. The tumor cells were negative for a large panel of immunohistochemical markers, except CD10. MDM2 immunohistochemical staining was also negative, leading to the diagnosis of FNCLCC grade III Undifferentiated Pleomorphic Sarcoma (UPS). aCGH showed a highly complex karyotype, with amplification of the 4q12 region, an area that contains only the PDGFRa gene...
January 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28105641/innominate-artery-cannulation-for-arterial-perfusion-during-aortic-arch-surgery
#16
Gaku Uchino, Keiji Yunoki, Naoya Sakoda, Munehiro Saiki, Kunikazu Hisamochi, Hideo Yoshida
OBJECTIVE: Antegrade cerebral perfusion during aortic arch surgery plays an important role in improving postoperative neurological outcomes. We report our experience using innominate artery cannulation for arterial perfusion during aortic arch surgery. METHODS: From January 2008 to December 2015, 159 patients underwent aortic arch surgery using innominate artery perfusion and were included in the study analysis (mean age, 71.4 ± 9.1 years; male, 120). RESULTS: Total arch replacement was performed in 84...
January 20, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28105235/impact-of-chemotherapy-on-eosinophilia-associated-advanced-rectal-cancer-a-case-report-and-review-of-the-literature
#17
Maki Inoue, Jun Kadono, Hiroshi Sugita, Toshihiro Nakazono, Shunsuke Motoi, Iwao Kitazono, Yuko Goto, Yoshihiko Fukukura, Makoto Yoshimitsu, Takaharu Misaka, Yutaka Imoto
The present study reports a case of eosinophilia-associated rectal cancer that was successfully stabilized using chemotherapy, and reviews the mechanisms of eosinophilia and the importance of chemotherapy. A 65-year-old man, who had previously been diagnosed with suspected rectal cancer, presented with the chief complaint of melena. Eosinophilia, abnormal blood coagulation, and elevated carcinoembryonic antigen and carbohydrate antigen 19-9 tumor marker levels were observed, and the patient was subsequently diagnosed with advanced rectal cancer accompanied by multiple lymph node metastases that extended from the para-aortic lymph nodes to the left axillary lymph nodes...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105135/takayasu-s-arteritis-presenting-with-common-carotid-artery-dissection-a-rare-case-report
#18
Ruonan Hao, Jie Zhang, Zhicheng Ma, Ming Xiao, Lei Zhou, Nan Kang, Xiaoyu Liang, Fuxin Li
Takayasu's arteritis (TA) is a rare, idiopathic, chronic inflammatory disease associated with cell-mediated inflammation and involving predominantly the aorta and its primary branches. TA results in stenosis, occlusion or aneurysmal degeneration of large arteries pathologically. However, the incidence of dissection in arteries is low. As one of the primary causes of aortic dissection-associated ischemic stroke in young adults, only a limited number of TA cases presenting with aortic dissection have been published to date...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104951/aortic-atresia-with-normal-sized-left-ventricle
#19
Priya Jagia, Arun Sharma, Saurabh K Gupta, Munish Guleria
Aortic atresia with an associated ventricular septal defect and adequate sized left ventricle is extremely rare. We present two cases in which an alternate diagnosis was suggested on echocardiography because the hypoplastic aortic trunk was missed due to its small caliber. The final diagnosis was, however, clinched on dual source computed tomography, which not only showed the thin aortic trunk but also clearly depicted the coronary artery origins from the hypoplastic aortic root. To the best of our knowledge, use of multi-detector computed tomography in aortic atresia with well developed left ventricle has not been reported in literature till date...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28104936/myelopathy-in-adult-aortic-coarctation-causes-and-caveats-of-an-atypical-presentation
#20
Chandan Mourya, Ashish Verma, Anand Bansal, Ram C Shukla, Arvind Srivastava
A 57-year-old female presenting with acute-onset paraplegia was referred for magnetic resonance imaging (MRI) of cervico-dorsal spine. On MRI, multiple tortuous dilated vessels were noted in the epidural space with long segment cord compression and imaging features of compressive myelopathy. Associated small acute cervico-dorsal epidural hematoma was also noted in the same region. Computed tomography (CT) angiography was performed subsequently which revealed post-ductal coarctation of aorta with multiple arterial collaterals in the chest wall and spinal canal...
October 2016: Indian Journal of Radiology & Imaging
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