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JOURNAL ARTICLE
Guillaume Geslain, Aurélie Cointe, Jérôme Naudin, Stéphane Dauger, Nora Poey, Justine Pages, Enora Le Roux, Stéphane Bonacorsi
BACKGROUND: Community-acquired and nosocomial lower-respiratory-tract infections in critically ill pediatric patients require early appropriate antibiotic therapy to optimize outcomes. Using blind bronchial samples, we assessed the diagnostic performance of the rapid-multiplex polymerase chain reaction (PCR) assay BioFire Pneumonia plus Panel vs. reference standard culturing with antimicrobial susceptibility testing. METHODS: For this prospective observational study in a single pediatric intensive care unit, we included consecutive patients younger than 18 years admitted for suspected community-, hospital- or ventilator-associated pneumonia in 2021-2022...
April 8, 2024: Pediatric Infectious Disease Journal
#22
Trystan A Innes, Samuel R Massey, Hezborn M Magacha, Venkata Vedantam, Neethu Vedantam
This case outlines the complications of Roux-en-Y gastric bypass surgery (RYGBS) and demonstrates clinical manifestations of several vitamin deficiencies. We present a 45-year-old female patient who was admitted to our hospital with generalized weakness, anasarca, hypotension, and failure to thrive, a year after she had her RYGBS. After the procedure, she had nausea, vomiting, and diarrhea with progressive inability to tolerate any oral intake. Subsequently, the patient lost over 200 pounds and got bedridden...
March 2024: Curēus
#23
Milly Mrinalini Tadigiri, Arub Imam, Rishab J Martins, Feral Daruwala
Cancer is a well-recognized risk factor for thromboembolic events and thromboembolism. This case report presents the rare coexistence of rectal carcinoma and pulmonary artery thrombosis in a female patient. A 44-year-old female presented with complaints of abdominal pain, vomiting, and obstipation. She had recently been diagnosed with rectal carcinoma. She had not undergone any invasive procedures in the past. Given the possibility of intestinal obstruction, an exploratory laparotomy was performed, followed by retrocolic gastrojejunostomy with Roux-en-Y anastomosis with a feeding JT tube insertion...
March 2024: Curēus
#24
JOURNAL ARTICLE
Trond Sand, Arnstein Grøtting, Martin Uglem, Nils Augestad, Gjermund Johnsen, Jorunn Sandvik
OBJECTIVE: We searched for long-term peripheral nerve complications 10-15 years after Roux-en-Y gastric bypass surgery (RYGB), using a comprehensive nerve conduction study (NCS) protocol. METHODS: Patients (n = 175, mean age 52.0, BMI 35.2) and 86 community-controls (mean age 56.8, BMI 27.2) had NCS of one upper and lower limb. New abnormality scores from 27 polyneuropathy-relevant (PNP27s) and four carpal tunnel syndrome-relevant NCS-measures (CTS4s) were compared between groups with non-parametric statistics...
2024: Clinical Neurophysiology Practice
#25
JOURNAL ARTICLE
Saskia B Wortmann, Rene G Feichtinger, Lucia Abela, Loes A van Gemert, Mélodie Aubart, Claire-Marine Dufeu-Berat, Nathalie Boddaert, Rene de Coo, Lara Stühn, Jasmijn Hebbink, Wolfram Heinritz, Julia Hildebrandt, Nastassja Himmelreich, Christoph Korenke, Anna Lehman, Thomas Leyland, Christine Makowski, Rafael Jenaro Martinez Marin, Pauline Marzin, Chris Mühlhausen, Marlène Rio, Agnes Rotig, Charles-Joris Roux, Manuel Schiff, Tobias B Haack, Steffen Syrbe, Stas A Zylicz, Christian Thiel, Maria Veiga da Cunha, Emile van Schaftingen, Matias Wagner, Johannes A Mayr, Ron A Wevers, Eugen Boltshauser, Michel A Willemsen
BACKGROUND AND OBJECTIVES: Hexokinase 1 (encoded by HK1 ) catalyzes the first step of glycolysis, the adenosine triphosphate-dependent phosphorylation of glucose to glucose-6-phosphate. Monoallelic HK1 variants causing a neurodevelopmental disorder (NDD) have been reported in 12 individuals. METHODS: We investigated clinical phenotypes, brain MRIs, and the CSF of 15 previously unpublished individuals with monoallelic HK1 variants and an NDD phenotype. RESULTS: All individuals had recurrent variants likely causing gain-of-function, representing mutational hot spots...
April 2024: Neurology. Genetics
#26
JOURNAL ARTICLE
Katharina Stevens, Hella Hultin, Magnus Sundbom
BACKGROUND: Bariatric procedures are associated with nutrient deficiencies. Studies show an association between gastric bypass (Roux-en-Y gastric bypass [RYGB]) and hypovitaminosis D as well as hyperparathyroidism, yet few compare RYGB to sleeve gastrectomy (SG), and large long-term analyses are scarce. OBJECTIVE: Evaluate trends of vitamin D and parathyroid hormone (PTH) levels in RYGB and SG. SETTING: National quality register. METHOD: The Scandinavian Obesity Surgery Registry records all bariatric surgeries in Sweden...
February 23, 2024: Surgery for Obesity and Related Diseases
#27
REVIEW
Alice Sanna, Martha Suárez-Mutis, Yann Lambert, Luisiane Carvalho, Hedley Cairo, Horace Cox, Clara de Bort, Margarete Gomes do Socorro Mendonça, David A Forero-Peña, Juan Carlos Gabaldón-Figueira, Maria Eugenia Grillet, François Klein, Clément Lazarus, Yassamine Lazrek, Jaime Louzada, Dorinaldo Malafaia, Paola Marchesini, Lise Musset, Joseli Oliveira-Ferreira, Cassio Peterka, Cyril Rousseau, Emmanuel Roux, Leopoldo Villegas, Stephen Vreden, Solène Wiedner-Papin, Gabriel Zorello Laporta, Helene Hiwat, Maylis Douine
The Guiana Shield, a small region of South America, is currently one of the main hotspots of malaria transmission on the continent. This Amazonian area is characterised by remarkable socioeconomic, cultural, health, and political heterogeneity and a high degree of regional and cross-border population mobility, which has contributed to the increase of malaria in the region in the past few years. In this context, regional cooperation to control malaria represents both a challenge and an indispensable initiative...
May 2024: Lancet Global Health
#28
REVIEW
Sevag Hamamah, Andras Hajnal, Mihai Covasa
Obesity remains a significant global health challenge, with bariatric surgery remaining as one of the most effective treatments for severe obesity and its related comorbidities. This review highlights the multifaceted impact of bariatric surgery beyond mere physical restriction or nutrient malabsorption, underscoring the importance of the gut microbiome and neurohormonal signals in mediating the profound effects on weight loss and behavior modification. The various bariatric surgery procedures, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), act through distinct mechanisms to alter the gut microbiome, subsequently impacting metabolic health, energy balance, and food reward behaviors...
April 5, 2024: Nutrients
#29
REVIEW
Muaaz Masood, Donald E Low, Shanley B Deal, Richard A Kozarek
Obesity is associated with several chronic conditions including diabetes, cardiovascular disease, and metabolic dysfunction-associated steatotic liver disease and malignancy. Bariatric surgery, most commonly Roux-en-Y gastric bypass and sleeve gastrectomy, is an effective treatment modality for obesity and can improve associated comorbidities. Over the last 20 years, there has been an increase in the rate of bariatric surgeries associated with the growing obesity epidemic. Sleeve gastrectomy is the most widely performed bariatric surgery currently, and while it serves as a durable option for some patients, it is important to note that several complications, including sleeve leak, stenosis, chronic fistula, gastrointestinal hemorrhage, and gastroesophageal reflux disease, may occur...
March 29, 2024: Journal of Clinical Medicine
#30
JOURNAL ARTICLE
Jamie P DeCicco, Juan S Barajas-Gamboa, Jerry T Dang, Gabriel Diaz Del Gobbo, Javed Raza, Carlos Abril, Alfredo D Guerron, Juan Pablo Pantoja, Safa Botros Hegazin, Ricard Corcelles, John Rodriguez, Matthew Kroh
Background: Bariatric surgery is an effective treatment for weight loss, but a higher body mass index (BMI) may lead to higher postoperative complication rates. This study aims to compare perioperative and postoperative outcomes between UAE patients with severe obesity (SO) [BMI ≥ 50 kg/m2 ] and non-severe obesity (NSO) [BMI < 50 kg/m2 ] undergoing primary bariatric surgery. Methods : From September 2015 to July 2019, 542 patients, 94 SO (56.5 ± 6.2 kg/m2 ) and 448 NSO (41.8 ± 4.1 kg/m2 ), were retrospectively reviewed...
March 26, 2024: Journal of Clinical Medicine
#31
REVIEW
Noura Jawhar, Jack W Sample, Marita Salame, Katie Marrero, Daniel Tomey, Suraj Puvvadi, Omar M Ghanem
Metabolic and bariatric surgery (MBS) is the most effective therapeutic intervention for patients with obesity, with sleeve gastrectomy (SG) being the most commonly performed primary MBS procedure. Long-term studies have demonstrated that 15-20% of patients require revisional bariatric surgery (RBS) due to weight-related issues or surgical complications. Despite the gold standard being laparoscopic revision, there are other available approaches such as open or robotic-assisted. An extensive literature review was performed for articles from their inception to February 2024...
March 25, 2024: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
David J Eldridge, Jingyi Ding, Josh Dorrough, Manuel Delgado-Baquerizo, Osvaldo Sala, Nicolas Gross, Yoann Le Bagousse-Pinguet, Max Mallen-Cooper, Hugo Saiz, Sergio Asensio, Victoria Ochoa, Beatriz Gozalo, Emilio Guirado, Miguel García-Gómez, Enrique Valencia, Jaime Martínez-Valderrama, César Plaza, Mehdi Abedi, Negar Ahmadian, Rodrigo J Ahumada, Julio M Alcántara, Fateh Amghar, Luísa Azevedo, Farah Ben Salem, Miguel Berdugo, Niels Blaum, Bazartseren Boldgiv, Matthew Bowker, Donaldo Bran, Chongfeng Bu, Rafaella Canessa, Andrea P Castillo-Monroy, Ignacio Castro, Patricio Castro-Quezada, Simone Cesarz, Roukaya Chibani, Abel Augusto Conceição, Anthony Darrouzet-Nardi, Yvonne C Davila, Balázs Deák, Paloma Díaz-Martínez, David A Donoso, Andrew David Dougill, Jorge Durán, Nico Eisenhauer, Hamid Ejtehadi, Carlos Ivan Espinosa, Alex Fajardo, Mohammad Farzam, Ana Foronda, Jorgelina Franzese, Lauchlan H Fraser, Juan Gaitán, Katja Geissler, Sofía Laura Gonzalez, Elizabeth Gusman-Montalvan, Rosa Mary Hernández, Norbert Hölzel, Frederic Mendes Hughes, Oswaldo Jadan, Anke Jentsch, Mengchen Ju, Kudzai F Kaseke, Melanie Köbel, Anika Lehmann, Pierre Liancourt, Anja Linstädter, Michelle A Louw, Quanhui Ma, Mancha Mabaso, Gillian Maggs-Kölling, Thulani P Makhalanyane, Oumarou Malam Issa, Eugene Marais, Mitchel McClaran, Betty Mendoza, Vincent Mokoka, Juan P Mora, Gerardo Moreno, Seth Munson, Alice Nunes, Gabriel Oliva, Gastón R Oñatibia, Brooke Osborne, Guadalupe Peter, Margerie Pierre, Yolanda Pueyo, R Emiliano Quiroga, Sasha Reed, Ana Rey, Pedro Rey, Víctor Manuel Reyes Gómez, Víctor Rolo, Matthias C Rillig, Peter C le Roux, Jan Christian Ruppert, Ayman Salah, Phokgedi Julius Sebei, Anarmaa Sharkhuu, Ilan Stavi, Colton Stephens, Alberto L Teixido, Andrew David Thomas, Katja Tielbörger, Silvia Torres Robles, Samantha Travers, Orsolya Valkó, Liesbeth van den Brink, Frederike Velbert, Andreas von Heßberg, Wanyoike Wamiti, Deli Wang, Lixin Wang, Glenda M Wardle, Laura Yahdjian, Eli Zaady, Yuanming Zhang, Xiaobing Zhou, Fernando T Maestre
Perennial plants create productive and biodiverse hotspots, known as fertile islands, beneath their canopies. These hotspots largely determine the structure and functioning of drylands worldwide. Despite their ubiquity, the factors controlling fertile islands under conditions of contrasting grazing by livestock, the most prevalent land use in drylands, remain virtually unknown. Here we evaluated the relative importance of grazing pressure and herbivore type, climate and plant functional traits on 24 soil physical and chemical attributes that represent proxies of key ecosystem services related to decomposition, soil fertility, and soil and water conservation...
April 12, 2024: Nature Plants
#33
JOURNAL ARTICLE
Stefano Aliberti, Felix C Ringshausen, Raja Dhar, Charles S Haworth, Michael R Loebinger, Katerina Dimakou, Megan L Crichton, Anthony De Soyza, Montse Vendrell, Pierre-Regis Burgel, Melissa McDonnell, Sabina Skrgat, Luis Maiz Carro, Andres de Roux, Oriol Sibila, Apostolos Bossios, Menno van der Eerden, Paula Kauppi, Robert Wilson, Branislava Milenkovic, Rosario Menendez, Marlene Murris, Sermin Borekci, Oxana Munteanu, Dusanka Obradovic, Adam Nowinski, Adelina Amorim, Antoni Torres, Natalie Lorent, Eva Van Braeckel, Josje Altenburg, Amelia Shoemark, Michal Shteinberg, Wim Boersma, Pieter C Goeminne, J Stuart Elborn, Adam T Hill, Tobias Welte, Francesco Blasi, Eva Polverino, James D Chalmers
INTRODUCTION: A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In the EMBARC registry, we tested whether sputum colour would be associated with disease severity and clinical outcomes. METHODS: Prospective, observational registry of adults with bronchiectasis conducted in 31 countries. Patients who did not produce spontaneous sputum were excluded from the analysis. The Murray sputum colour chart was used at baseline and at follow-up visits...
April 12, 2024: European Respiratory Journal
#34
REVIEW
Silvia Rosanna Casati, Davide Cervia, Paulina Roux-Biejat, Claudia Moscheni, Cristiana Perrotta, Clara De Palma
Duchenne muscular dystrophy (DMD) is a genetic progressive muscle-wasting disorder that leads to rapid loss of mobility and premature death. The absence of functional dystrophin in DMD patients reduces sarcolemma stiffness and increases contraction damage, triggering a cascade of events leading to muscle cell degeneration, chronic inflammation, and deposition of fibrotic and adipose tissue. Efforts in the last decade have led to the clinical approval of novel drugs for DMD that aim to restore dystrophin function...
March 26, 2024: Cells
#35
JOURNAL ARTICLE
Chané de Beer, Rebecca J Bennett, Robert H Eikelboom, Talita le Roux
PURPOSE: While the impact of paediatric cochlear implantation on parents and siblings are recognised, limited evidence exists regarding the effect of paediatric cochlear implantation on the entire family life (e.g., routine interactions, family activities). This study aimed to describe the impact of paediatric cochlear implantation on family life as perceived by parents, using concept mapping. MATERIALS AND METHODS: Parents of paediatric cochlear implant (CI) recipients ( n = 29) participated in this concept mapping study to generate, group, and rate statements regarding the impact of paediatric cochlear implantation on family life...
April 12, 2024: Disability and Rehabilitation
#36
JOURNAL ARTICLE
Tianxiao Wei, Zhouqiao Wu, Yufan Chen, Yingai Li, Fei Pang, Fei Shan, Ziyu Li, Jiafu Ji
BACKGROUND: This study aimed to compare the clinical outcomes and patient benefits of uncut Roux-en-Y (URY) anastomosis and Billroth-II with Braun (BB) anastomosis after distal gastrectomy. METHODS: We retrospectively reviewed the data of patients who underwent URY or BB anastomosis after distal gastrectomy between March 2015 and December 2017. Clinical characteristics, survival data, postoperative recovery data, and long-term outcomes were recorded and compared between the two groups...
2024: Frontiers in Surgery
#37
JOURNAL ARTICLE
Taryar Tun, Tina Marinelli, Ken Liu, Simone I Strasser, Michael Crawford, Asad E Patanwala
BACKGROUND: Surgical site infection (SSI) after liver transplant (LT) is common, but no studies have been conducted in Australia. The purpose of this study was to determine the proportion of patients who developed an SSI post-LT in Australia's largest LT unit. METHODS: This was a single-center retrospective cohort study. We included all LT recipients who were aged 18 years or more and received their transplant between March 1, 2018 and April 1, 2023. The primary outcome was to determine the proportion of LT recipients who developed an SSI within 30 days of transplantation...
April 11, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#38
JOURNAL ARTICLE
Zhangli Zuo, Milena Edna Roux, Yasin F Dagdas, Eleazar Rodriguez, Morten Petersen
Evolutionarily conserved protein associated with topoisomerase II (PAT1) proteins activate mRNA decay through binding mRNA and recruiting decapping factors to optimize posttranscriptional reprogramming. Here, we generated multiple mutants of pat1, pat1 homolog 1 (path1), and pat1 homolog 2 (path2) and discovered that pat triple mutants exhibit extremely stunted growth and all mutants with pat1 exhibit leaf serration while mutants with pat1 and path1 display short petioles. All three PATs can be found localized to processing bodies and all PATs can target ASYMMETRIC LEAVES 2-LIKE 9 transcripts for decay to finely regulate apical hook and lateral root development...
April 11, 2024: FEBS Letters
#39
JOURNAL ARTICLE
Qichao Lian, Bruno Huettel, Birgit Walkemeier, Baptiste Mayjonade, Céline Lopez-Roques, Lisa Gil, Fabrice Roux, Korbinian Schneeberger, Raphael Mercier
Although originally primarily a system for functional biology, Arabidopsis thaliana has, owing to its broad geographical distribution and adaptation to diverse environments, developed into a powerful model in population genomics. Here we present chromosome-level genome assemblies of 69 accessions from a global species range. We found that genomic colinearity is very conserved, even among geographically and genetically distant accessions. Along chromosome arms, megabase-scale rearrangements are rare and typically present only in a single accession...
April 11, 2024: Nature Genetics
#40
JOURNAL ARTICLE
Catherine Riou, Jinal N Bhiman, Yashica Ganga, Shobna Sawry, Frances Ayres, Richard Baguma, Sashkia R Balla, Ntombi Benede, Mallory Bernstein, Asiphe S Besethi, Sandile Cele, Carol Crowther, Mrinmayee Dhar, Sohair Geyer, Katherine Gill, Alba Grifoni, Tandile Hermanus, Haajira Kaldine, Roanne S Keeton, Prudence Kgagudi, Khadija Khan, Erica Lazarus, Jean Le Roux, Gila Lustig, Mashudu Madzivhandila, Siyabulela F J Magugu, Zanele Makhado, Nelia P Manamela, Qiniso Mkhize, Paballo Mosala, Thopisang P Motlou, Hygon Mutavhatsindi, Nonkululeko B Mzindle, Anusha Nana, Rofhiwa Nesamari, Amkele Ngomti, Anathi A Nkayi, Thandeka P Nkosi, Millicent A Omondi, Ravindre Panchia, Faeezah Patel, Alessandro Sette, Upasna Singh, Strauss van Graan, Elizabeth M Venter, Avril Walters, Thandeka Moyo-Gwete, Simone I Richardson, Nigel Garrett, Helen Rees, Linda-Gail Bekker, Glenda Gray, Wendy A Burgers, Alex Sigal, Penny L Moore, Lee Fairlie
We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S, with 91.4% showing evidence of previous SARS-CoV-2 infection. A total of 286 adults (with or without HIV) were enrolled >4 months after an Ad26.COV2.S prime and randomized 1:1:1:1 to receive either a full or half-dose booster of Ad26.COV2.S or BNT162b2 vaccine. B cell responses (binding, neutralization and antibody dependent cellular cytotoxicity-ADCC), and spike-specific T-cell responses were evaluated at baseline, 2, 12 and 24 weeks post-boost...
2024: PLOS Glob Public Health
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