keyword
https://read.qxmd.com/read/38514936/rabit-iii-an-automated-micronucleus-assay-at-a-non-specialized-biodosimetry-facility
#21
JOURNAL ARTICLE
Mikhail Repin, Guy Garty, Ralph J Garippa, David J Brenner
Micronuclei, detected through the cytokinesis-block micronucleus assay, are valuable indicators of ionizing radiation exposure, especially in short-term lymphocyte cultures. The peripheral human blood lymphocyte assay is recognized as a prime candidate for automated biodosimetry. In a prior project at the Columbia University Center for Radiological Research, we automated this assay using the 96-well ANSI/SLAS microplate standard format and relied on established biotech robotic systems named Rapid Automated Biodosimetry Tool (RABiT)...
March 22, 2024: Radiation Research
https://read.qxmd.com/read/38513178/expanding-research-on-firefighter-trainee-fitness-reasons-for-academy-release-and-the-predictive-capabilities-of-fitness-tests
#22
JOURNAL ARTICLE
Robert G Lockie, Robin M Orr, Fernando Montes, J Jay Dawes
Lockie, RG, Orr, RM, Montes, F, and Dawes, JJ. Expanding research on firefighter trainee fitness, reasons for academy release, and the predictive capabilities of fitness tests. J Strength Cond Res 38(4): 724-733, 2024-Firefighter trainees need a level of fitness to be admitted to and complete a training academy. Fitness could indicate a trainee's likelihood of graduation, in addition to their reasons for release. This study determined fitness differences between firefighter trainees who graduated (GRAD) from academy or were released because of injury (RELI), performance test failures (RELP), or resignation (RELR), and whether fitness predicted graduation...
April 1, 2024: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/38512865/chainagile-a-framework-for-the-improvement-of-scrum-agile-distributed-software-development-based-on-blockchain
#23
JOURNAL ARTICLE
Junaid Nasir Qureshi, Muhammad Shoaib Farooq
Software Development based on Scrum Agile in a distributed development environment plays a pivotal role in the contemporary software industry by facilitating software development across geographic boundaries. However, in the past different frameworks utilized to address the challenges like communication and collaboration in scrum agile distributed software development (SADSD) were notably inadequate in transparency, security, traceability, geographically dispersed location work agreements, geographically dispersed teamwork effectiveness, and trust...
2024: PloS One
https://read.qxmd.com/read/38512249/vibration-controlled-transient-elastography-scores-to-predict-liver-related-events-in-steatotic-liver-disease
#24
JOURNAL ARTICLE
Huapeng Lin, Hye Won Lee, Terry Cheuk-Fung Yip, Emmanuel Tsochatzis, Salvatore Petta, Elisabetta Bugianesi, Masato Yoneda, Ming-Hua Zheng, Hannes Hagström, Jérôme Boursier, José Luis Calleja, George Boon-Bee Goh, Wah-Kheong Chan, Rocio Gallego-Durán, Arun J Sanyal, Victor de Lédinghen, Philip N Newsome, Jian-Gao Fan, Laurent Castéra, Michelle Lai, Stephen A Harrison, Céline Fournier-Poizat, Grace Lai-Hung Wong, Grazia Pennisi, Angelo Armandi, Atsushi Nakajima, Wen-Yue Liu, Ying Shang, Marc de Saint-Loup, Elba Llop, Kevin Kim-Jun Teh, Carmen Lara-Romero, Amon Asgharpour, Sara Mahgoub, Mandy Sau-Wai Chan, Clemence M Canivet, Manuel Romero-Gomez, Seung Up Kim, Vincent Wai-Sun Wong
IMPORTANCE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic liver disease worldwide. It is important to develop noninvasive tests to assess the disease severity and prognosis. OBJECTIVE: To study the prognostic implications of baseline levels and dynamic changes of the vibration-controlled transient elastography (VCTE)-based scores developed for the diagnosis of advanced fibrosis (Agile 3+) and cirrhosis (Agile 4) in patients with MASLD...
March 21, 2024: JAMA
https://read.qxmd.com/read/38507614/when-false-positives-arise-troubleshooting-a-sars-coronavirus-2-sars-cov-2-detection-assay-on-a-semi-automated-platform
#25
JOURNAL ARTICLE
Kenneth J Hampel, Diana L Gerrard, Denise Francis, Jordan Armstrong, Margaret Cameron, Alexa Ostafin, Briege Mahoney, Miles Malik, Nikoletta Sidiropoulos
BACKGROUND: During the COVID-19 pandemic, many molecular diagnostic laboratories performed high-throughput SARS-CoV-2 testing often with implementation of automated workflows. In parallel, vaccination campaigns resulted increasingly in specimens from fully vaccinated patients, with resultant clinical inquiries regarding positive results in this patient population. This prompted a quality improvement initiative to investigate the semi-automated testing workflow for false-positive results...
March 20, 2024: Journal of Applied Laboratory Medicine
https://read.qxmd.com/read/38507123/clean-and-accurate-soil-quality-monitoring-in-mining-areas-under-environmental-rehabilitation-in-the-eastern-brazilian-amazon
#26
JOURNAL ARTICLE
Douglas Silva Dos Santos, Paula Godinho Ribeiro, Renata Andrade, Sérgio Henrique Godinho Silva, Markus Gastauer, Cecílio Fróis Caldeira, Rafael Silva Guedes, Yan Nunes Dias, Pedro Walfir Martins Souza Filho, Silvio Junio Ramos
Soil quality monitoring in mining rehabilitation areas is a crucial step to validate the effectiveness of the adopted recovery strategy, especially in critical areas for environmental conservation, such as the Brazilian Amazon. The use of portable X-ray fluorescence (pXRF) spectrometry allows a rapid quantification of several soil chemical elements, with low cost and without residue generation, being an alternative for clean and accurate environmental monitoring. Thus, this work aimed to assess soil quality in mining areas with different stages of environmental rehabilitation based on predictions of soil fertility properties through pXRF along with four machine learning algorithms (projection pursuit regression, PPR; support vector machine, SVM; cubist regression, CR; and random forest, RF) in the Eastern Brazilian Amazon...
March 20, 2024: Environmental Monitoring and Assessment
https://read.qxmd.com/read/38504840/development-of-agile-scrum-perception-tool-to-evaluate-students-opinions-on-agile-methodology-in-nursing-education
#27
JOURNAL ARTICLE
Suseela Thiyagarajan, Prakash R M Saldanha, Radhakrishnan Govindan, K C Leena, P V Prathyusha
BACKGROUND AND AIM: Agile methodology (AM) is an innovative, active, team-based learning method that enhances higher-order thinking (metacognitive ability), collaboration, hands-on training, and student engagement in the classroom and clinical environment. Exploring the student's opinions of AM in teaching helps understand how agile can be utilized in higher education to positively improve learning ability, leadership, and teamwork. Hence, the study aimed to develop the agile scrum perception tool (ASPT) to evaluate the opinions on AM among nursing students...
2024: International Journal of Applied and Basic Medical Research
https://read.qxmd.com/read/38503060/ultrasound-viscous-reduction-effects-on-the-proteolysis-of-soy-protein-isolate-at-a-limited-degree-of-hydrolysis-changes-in-the-functional-characteristics-and-protein-structure
#28
JOURNAL ARTICLE
Yolandani, Haile Ma, Dandan Liu, Yu Cheng, Fredy Agil Raynaldo, Mokhtar Dabbour, Jiapin Chao, Asad Ali, Susu Yang
High-concentration soy protein isolate was subjected to ultrasonication for viscosity reduction to assist the process of limited enzymatic hydrolysis. Ultrasonication (20 kHz, 10 min, 160 W/L) effectively reduced the viscosity of soy protein isolate at a comparatively high concentration of 14 % (w/v) and promoted the limited enzymatic hydrolysis (controlled degree of hydrolysis of 12 %) with a higher peptide yield than that of the conventional method. The correlations between substrate viscosity and peptide yield, as well as the viscosities of the resulting hydrolysates, were studied...
March 11, 2024: Ultrasonics Sonochemistry
https://read.qxmd.com/read/38501481/adaptable-sec-saxs-data-collection-for-higher-quality-structure-analysis-in-solution
#29
JOURNAL ARTICLE
Tsutomu Matsui, Ivan Rajkovic, Blaine H M Mooers, Ping Liu, Thomas M Weiss
The two major challenges in synchrotron size-exclusion chromatography coupled in-line with small-angle x-ray scattering (SEC-SAXS) experiments are the overlapping peaks in the elution profile and the fouling of radiation-damaged materials on the walls of the sample cell. In recent years, many post-experimental analyses techniques have been developed and applied to extract scattering profiles from these problematic SEC-SAXS data. Here, we present three modes of data collection at the BioSAXS Beamline 4-2 of the Stanford Synchrotron Radiation Lightsource (SSRL BL4-2)...
April 2024: Protein Science
https://read.qxmd.com/read/38499788/tor-regulates-variability-of-protein-synthesis-rates
#30
JOURNAL ARTICLE
Clovis Basier, Paul Nurse
Cellular processes are subject to inherent variability, but the extent to which cells can regulate this variability has received little investigation. Here, we explore the characteristics of the rate of cellular protein synthesis in single cells of the eukaryote fission yeast. Strikingly, this rate is highly variable despite protein synthesis being dependent on hundreds of reactions which might be expected to average out at the overall cellular level. The rate is variable over short time scales, and exhibits homoeostatic behaviour at the population level...
March 18, 2024: EMBO Journal
https://read.qxmd.com/read/38496687/pd-l1-mrna-derived-from-tumor-educated-platelets-as-a-potential-immunotherapy-biomarker-in-non-small-cell-lung-cancer
#31
JOURNAL ARTICLE
Zhihuang Hu, Na Wang, Yao Zhang, Daoyun Zhang, Si Sun, Hui Yu, Ying Lin, Xinmin Zhao, Huijie Wang, Xianghua Wu, Yoshinobu Ichiki, Satoshi Watanabe, Ziying Gong, Jianhua Chang, Jialei Wang
BACKGROUND: To date, the role of programmed death ligand-1 (PD-L1) messenger RNA (mRNA) derived from tumor-educated platelets (TEPs) has not been well investigated in patients with advanced non-small cell lung cancer (NSCLC). A few reports have examined whether mRNA in TEPs can predict the clinical responses of patients with advanced NSCLC following immunotherapy. This study aimed to identify novel biomarkers to improve the clinical benefits and outcomes of NSCLC patients. METHODS: Advanced NSCLC patients receiving a combination of immunotherapy and chemotherapy, or immunotherapy alone as a first- or second-line treatment at the Fudan University Shanghai Cancer Center were enrolled in this study...
February 29, 2024: Translational Lung Cancer Research
https://read.qxmd.com/read/38496314/ameliorative-effects-of-propolis-and-wheat-germ-oil-on-acute-toxoplasmosis-in-experimentally-infected-mice-are-associated-with-reduction-in-parasite-burden-and-restoration-of-histopathological-changes-in-the-brain-uterus-and-kidney
#32
JOURNAL ARTICLE
Ehab Kotb Elmahallawy, Fatma Abo Zakaib Ali, Enrique Raya-Álvarez, Alaa Fehaid, Khaled A Abd El-Razik, Hassan Ali Mohamed El Fadaly, Manal F El-Khadragy, Amal S M Sayed, Ashraf H Soror, Alaa S Alhegaili, Amira A Saleh, Abdulsalam A M Alkhaldi, Abd El-Nasser A Madboli, Ahmad Agil, Ashraf Mohamed Barakat
Toxoplasmosis continues to be a prevalent parasitic zoonosis with a global distribution. This disease is caused by an intracellular parasite known as Toxoplasma gondii , and the development of effective novel drug targets to combat it is imperative. There is limited information available on the potential advantages of wheat germ oil (WGO) and propolis, both individually and in combination, against the acute phase of toxoplasmosis. In this study, acute toxoplasmosis was induced in Swiss albino mice, followed by the treatment of infected animals with WGO and propolis, either separately or in combination...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38489600/exploring-the-impact-of-firefighter-trainee-fitness-on-academy-graduation-or-release
#33
JOURNAL ARTICLE
Robert G Lockie, Robin M Orr, Fernando Montes, J Jay Dawes
Lockie, RG, Orr, RM, Montes, F, and Dawes, JJ. A research note exploring the impact of firefighter trainee fitness on academy graduation or release. J Strength Cond Res XX(X): 000-000, 2024-This study investigated the impact of fitness test performance on firefighter trainee ability to graduate an academy using ordinal logistic generalized linear models. Retrospective analysis was conducted on trainee data (N = 686) from one fire department who completed an occupational physical ability test (OPAT) that included the following: Illinois agility test (IAT); push-ups; pull-ups; leg tucks; maximal aerobic capacity (V̇o2max); backward overhead 4...
March 14, 2024: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/38486382/molecular-docking-and-admet-analysis-strategy-based-stability-indicating-rp-hplc-pda-method-development-and-validation-of-toremifene
#34
JOURNAL ARTICLE
Shamshir Khan, Makhmur Ahmad, Zabih Ullah, Sana Hashmi, Md Sajid Ali, Sharwan Hudda
BACKGROUND: The purpose of this research is to develop an analytical method and validate it according to ICH guidelines for the estimation of Toremifene by RP-HPLC-PDA with molecular docking and ADMET analysis. From molecular docking, it came to know the receptor affinity specifically to estrogen receptors (ERα and ERβ), which are responsible for cancer therapy. ADMET analyses secure its therapeutic potential as well safety of the drug. METHODS: An isocratic method has developed by RP-HPLC-PDA (AGILENT 1100) with symmetry of 100 mm x 4...
March 13, 2024: Current Computer-aided Drug Design
https://read.qxmd.com/read/38484363/evaluation-of-multi-directional-speed-qualities-throughout-adolescence-in-youth-soccer-the-non-linear-nature-of-transfer
#35
JOURNAL ARTICLE
James H Dugdale, Tony Myers, Dajo Sanders, Matthew Andrew, Richard Clarke, Angus M Hunter
Training and assessment of agility is often prioritised by soccer coaches and practitioners aiming to develop multi-directional speed. Although the importance of agility is advocated throughout childhood and adolescence, limited data evidence agility performance at different stages of adolescence. The purpose of this study was to examine differences in multi-directional speed performance in youth soccer players spanning an entire soccer academy. A total of 86 male junior-elite soccer players volunteered to participate...
March 14, 2024: Journal of Sports Sciences
https://read.qxmd.com/read/38483014/implementation-frameworks-guiding-digital-self-management-intervention-in-chronic-pain-a-scoping-review
#36
REVIEW
R de la Vega, S L Bartels, R W Wicksell
BACKGROUND AND OBJECTIVE: The development, evaluation and implementation of digital self-management interventions for chronic pain have increased exponentially. While intervention outcomes appear promising to improve well-being and functioning in target populations, it is unclear how the development and evaluation processes were structured and how implementation was planned and executed. The aim of this systematic review is to provide a comprehensive overview of implementation frameworks used to guide and evaluate scientific innovation in chronic pain...
March 14, 2024: European Journal of Pain: EJP
https://read.qxmd.com/read/38481558/a-simple-and-rapid-lc-ms-ms-method-for-the-quantification-of-nirmatrelvir-ritonavir-in-plasma-of-patients-with-covid-19
#37
JOURNAL ARTICLE
Xiujing Zhu, Lin Li, Bing Dai, Zhijun Liu, Zhipeng Wang, Lili Cui, Shouhong Gao, Wansheng Chen, Xia Tao, Deduo Xu
The combined prescriptions of nirmatrelvir/ritonavir and other drugs are limited due to potential drug-drug interactions, so therapeutic drug monitoring (TDM) becomes particularly important. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established for determination of the nirmatrelvir/ritonavir in plasma of patients with COVID-19, providing technical and theoretical support for the TDM. Plasma samples were processed by protein precipitation using acetonitrile, and analytes were separated on an Agilent Poroshell 120 SB-C18 (2...
2024: International Journal of Analytical Chemistry
https://read.qxmd.com/read/38481197/one-size-doesn-t-fit-all-methodological-reflections-in-conducting-community-based-behavioural-science-research-to-tailor-covid-19-vaccination-initiatives-for-public-health-priority-populations
#38
JOURNAL ARTICLE
Guillaume Fontaine, Maureen Smith, Tori Langmuir, Karim Mekki, Hanan Ghazal, Elizabeth Estey Noad, Judy Buchan, Vinita Dubey, Andrea M Patey, Nicola McCleary, Emily Gibson, Mackenzie Wilson, Amjad Alghamyan, Kateryna Zmytrovych, Kimberly Thompson, Jacob Crawshaw, Jeremy M Grimshaw, Trevor Arnason, Jamie Brehaut, Susan Michie, Melissa Brouwers, Justin Presseau
BACKGROUND: Promoting the uptake of vaccination for infectious diseases such as COVID-19 remains a global challenge, necessitating collaborative efforts between public health units (PHUs) and communities. Applied behavioural science can play a crucial role in supporting PHUs' response by providing insights into human behaviour and informing tailored strategies to enhance vaccination uptake. Community engagement can help broaden the reach of behavioural science research by involving a more diverse range of populations and ensuring that strategies better represent the needs of specific communities...
March 13, 2024: BMC Public Health
https://read.qxmd.com/read/38478592/anymal-parkour-learning-agile-navigation-for-quadrupedal-robots
#39
JOURNAL ARTICLE
David Hoeller, Nikita Rudin, Dhionis Sako, Marco Hutter
Performing agile navigation with four-legged robots is a challenging task because of the highly dynamic motions, contacts with various parts of the robot, and the limited field of view of the perception sensors. Here, we propose a fully learned approach to training such robots and conquer scenarios that are reminiscent of parkour challenges. The method involves training advanced locomotion skills for several types of obstacles, such as walking, jumping, climbing, and crouching, and then using a high-level policy to select and control those skills across the terrain...
March 13, 2024: Science Robotics
https://read.qxmd.com/read/38478545/sensory-function-and-somatosensorial-system-changes-according-to-visual-acuity-and-throwing-techniques-in-goalball-players-a-cross-sectional-study
#40
JOURNAL ARTICLE
Ayşenur Gökşen, Gonca İnce
The somatosensory system is a complect sensory system that differentiates individual athletes. The aim of this study is to investigate the effect of visual acuity level on throwing technique, proprioceptive sense of the shoulder joint, light touch and two-point discrimination sense of the upper extremity, and sensory function (postural control and reaction time) in visually impaired goalball players. Goalball players who have different visual acuities B1(unable to perceive light or recognize its shape); B2 (has a visual field of less than 5 degrees and can recognize shapes); B3 (visual field greater than 5 degrees and less than 20 degrees) participated in the study...
2024: PloS One
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