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https://www.readbyqxmd.com/read/29228409/short-term-effects-of-combined-high-intensity-strength-and-sprint-interval-training-on-anthropometric-characteristics-and-physical-performance-of-elite-team-handball-players
#1
Souhail Hermassi, Mohamed Souhail Chelly, Georg Fieseler, Thomas Bartels, Stephan Schulze, Karl-Stefan Delank, Roy J Shepard, René Schwesig
Muscular strength and speed are critical physical factors in determining the technical and tactical skills of elite team handball players. This study thus investigated the effect of high-intensity muscular strength and sprint interval training (SIT) on lower limb explosive performance and anthropometric characteristics in 22 male handball athletes aged 20.2 ± 0.1 years. A training group (TG, n = 12) and a control group (CG, n = 10) were followed over 8 weeks parallel to regular handball training...
December 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29222437/digital-pcr-for-gene-expression-impact-from-inherent-tissue-rna-degradation
#2
Melanie J Millier, Lisa K Stamp, Paul A Hessian
Subtle molecular differences indicate the heterogeneity present in a number of disease settings. Digital-PCR (dPCR) platforms achieve the necessary levels of sensitivity and accuracy over standard quantitative RT-PCR (qPCR) that promote their use for such situations, detecting low abundance transcript and subtle changes from gene expression. An underlying requisite is good quality RNA, principally dictated by appropriate tissue handling and RNA extraction. Here we consider the application of dPCR to measures of gene expression in pathological tissues with inherent necrosis, focusing on rheumatoid subcutaneous nodules...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29219390/inductive-spikes-in-the-crab-nebula-a-theory-of-%C3%AE-ray-flares
#3
John G Kirk, Gwenael Giacinti
We show that the mysterious, rapidly variable emission at ∼400  MeV observed from the Crab Nebula by the AGILE and Fermi satellites could be the result of a sudden drop in the mass loading of the pulsar wind. The current required to maintain wave activity in the wind is then carried by very few particles of a high Lorentz factor. On impacting the nebula, these particles produce a tightly beamed, high-luminosity burst of hard gamma rays, similar to those observed. This implies that (i) the emission is synchrotron radiation in the toroidal field of the nebula and, therefore, linearly polarized and (ii) this mechanism potentially contributes to the gamma-ray emission from other powerful pulsars, such as the Magellanic Cloud objects J0537-6910 and B0540-69...
November 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29218934/-quantative-analysis-of-eupatilin-and-jaceosidin-in-folium-of-artemisia-argyi-from-different-areas-in-china-by-rp-hplc-based-on-ancient-medicine-books
#4
Xian-Zhang Huang, Li-Ping Kang, Li Gao, Yuan Zhang, Lan-Ping Guo, Lu-Qi Huang
In order to evaluate the quality of Artemisia argyi from Qichun, Ningbo, Anguo and Nanyang, the contents of eupatilin and jaceosidin were determined by RP-HPLC. The determination was performed on Agilent Eclipse XDB-C₁₈ (4.6 mm×250 mm, 5 μm) with mobile phase consisted of acetonitrile-0.2% phosphoric acid(35∶65) at the flow rate 1.0 mL•min ⁻¹. The detection wavelength was 350 nm and the column temperature was 25 ℃. The results showed that the amount of eupatilin and jaceosidin had a clear linear relationship in the range of 0...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29210907/musculoskeletal-development-in-patients-with-down-syndrome
#5
Corey Dupre, Emily Weidman-Evans
Down syndrome is a chromosomal aneuploidy that results in disruptions in multiple body systems, including musculoskeletal function. Early intervention to focus on bone mineral density, gait correction, agility, balance, and muscle strength is imperative in order for patients to achieve maximum potential.
December 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29206159/energy-management-in-smart-cities-based-on-internet-of-things-peak-demand-reduction-and-energy-savings
#6
Chinmaya Mahapatra, Akshaya Kumar Moharana, Victor C M Leung
Around the globe, innovation with integrating information and communication technologies (ICT) with physical infrastructure is a top priority for governments in pursuing smart, green living to improve energy efficiency, protect the environment, improve the quality of life, and bolster economy competitiveness. Cities today faces multifarious challenges, among which energy efficiency of homes and residential dwellings is a key requirement. Achieving it successfully with the help of intelligent sensors and contextual systems would help build smart cities of the future...
December 5, 2017: Sensors
https://www.readbyqxmd.com/read/29201491/simultaneous-determination-of-six-active-components-in-oviductus-ranae-via-quantitative-analysis-of-multicomponents-by-single-marker
#7
Shihan Wang, Yang Xu, Yanwei Wang, Huailei Yang, Zuying Lv, Xiangqun Jin, Yongsheng Wang
A method, quantitative analysis of multicomponents by single marker (QAMS), was established in this article to investigate the quality control of a traditional Chinese medicine, Oviductus Ranae. 7-Hydroxycholesterol, 7-ketocholesterol, 4-cholesten-3-one, stigmasterol, 7-dehydrocholesterol, and cholesterol were selected as the indexes of quality evaluation of Oviductus Rana. The determination was achieved on an Agilent HC-C18 column (4.6 mm × 250 mm, 5 μm) using methanol with water (87 : 13 v/v) as mobile phase at the flow rate of 2...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29199782/anthropometric-and-physiological-characteristics-of-male-soccer-players-according-to-their-competitive-level-playing-position-and-age-group-a-systematic-review
#8
Maamer Slimani, Pantelis T Nikolaidis
BACKGROUND: The aim of the present systematic review was to profile soccer players' anthropometric, physiological, and physical attributes relative to different competitive levels, playing positions and age groups. METHODS: The systematic search was conducted using different databases and according to the Population/Intervention or Exposure/Comparison/Outcome(s) [PICO] criteria. RESULTS: The present review shows that the somatotype characteristics, percentage (%) of body fat, maximal oxygen uptake (VO2max), repeatedsprint ability (RSA), running speed, strength, and muscular power of the lower limbs were the most powerful discriminators between male soccer players of different competitive levels, playing positions, and age groups...
December 1, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29197526/pathway-analysis-of-differentially-expressed-genes-in-mycobacterium-bovis-challenged-bovine-macrophages
#9
Sanjeev Kumar Shukla, Shubhra Shukla, Anuj Chauhan, Sarvjeet, Rehan Khan, Anuj Ahuja, Lakshya Veer Singh, Nitin M Kamble, Anupam Dhasmana, Naveen Sharma, Bipin Chand, Ajay Vir Singh, Manjit Panigrahi
The immune signalling genes during challenge of bovine macrophages with bacterial products derived from disease causing bacteria in cattle were investigated. An in-vitro cell culture model were challenged to Mycobacterium bovis of bovine monocyte derived macrophages. Macrophages from healthy and already infected animals can both be fully activated during M. bovis infection. Analysis of mRNA abundance in peripheral blood mononuclear cells from M. bovis infected and non-infected cattle were performed as a controls...
November 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29193168/energy-response-corrections-for-profile-measurements-using-a-combination-of-different-detector-types
#10
Sonja Wegener, Otto A Sauer
PURPOSE: Different detector properties will heavily affect the results of off-axis measurements outside of radiation fields, where a different energy spectrum is encountered. While a diode detector would show a high spatial resolution, it contains high atomic number elements, which lead to perturbations and energy dependent response. An ionization chamber, on the other hand, has a much smaller energy-dependence, but shows dose averaging over its larger active volume. We suggest a way to obtain spatial energy-response corrections of a detector independent of its volume effect for profiles of arbitrary fields by using a combination of two detectors...
November 29, 2017: Medical Physics
https://www.readbyqxmd.com/read/29192448/-simultaneous-determination-of-six-triterpenoid-acids-from-guizhi-fuling-capsules-by-uplc-ms-ms
#11
Ying Ma, Jia-Chun Li, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao, Ya-Ling Song, Yong-Wen Zhang
To establish a UPLC-MS/MS method for simultaneous determination of six triterpenoid constituents (pachymic acid, dehydropachymic acid, dehydrotumulosic acid, polyporenic acid C, dehydroeburicoic acid and dehydrotra metenolic acid) in Guizhi Fuling capsules (GFC). Chromatographic analysis was conducted on Agilent Porosheell 120 SB-C₁₈ column (4.6 mm×150 mm, 2.7 μm), with 0.1% formic acid aqueous solution-methanol as the mobile phase for gradient elution at a flow rate of 0.4 mL•min-1. The column temperature was 30 ℃ and the sample size was 5 μL...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29191931/european-normative-values-for-physical-fitness-in-children-and-adolescents-aged-9-17-years-results-from-2-779-165-eurofit-performances-representing-30-countries
#12
Grant R Tomkinson, Kevin D Carver, Frazer Atkinson, Nathan D Daniell, Lucy K Lewis, John S Fitzgerald, Justin J Lang, Francisco B Ortega
OBJECTIVE: To develop sex-specific and age-specific normative values for the nine Eurofit tests in European children and adolescents aged 9-17 years. METHODS: A systematic review was undertaken to identify papers that explicitly reported descriptive results for at least one of nine Eurofit tests (measuring balance, muscular strength, muscular endurance, muscular power, flexibility, speed, speed-agility and cardiorespiratory fitness (CRF)) on children and adolescents...
November 30, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29189265/development-of-a-diagnostic-programmed-cell-death-1-ligand-1-immunohistochemistry-assay-for-nivolumab-therapy-in-melanoma
#13
Therese Phillips, Molly M Millett, Xiaoling Zhang, Malinka Jansson, Rachel Cleveland, Pauline Simmons, Gregory Cherryholmes, Josette Carnahan, Josette William, Betsy Spaulding, Ilana R Satnick, H David Inzunza, Clive Taylor, John Cogswell, James Novotny, Emin Oroudjev, Henrik Winther
Nivolumab is a monoclonal antibody that blocks the interaction between programmed cell death 1 (PD1) and programmed cell death 1-ligand 1 (PD-L1), resulting in enhanced antitumor activity by the immune system. Nivolumab is currently approved by the US Food and Drug Administration (FDA) for melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma, classical Hodgkin lymphoma, squamous cell carcinoma of the head and neck, and urothelial carcinoma. PD-L1 IHC 28-8 pharmDx is FDA-approved as a complementary diagnostic for immunohistochemical (IHC) detection of PD-L1 in non-squamous NSCLC and melanoma...
October 20, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29188362/the-nf-%C3%AE%C2%BAb-signalling-pathway-in-colorectal-cancer-associations-between-dysregulated-gene-and-mirna-expression
#14
Martha L Slattery, Lila E Mullany, Lori Sakoda, Wade S Samowitz, Roger K Wolff, John R Stevens, Jennifer S Herrick
BACKGROUND: The nuclear factor-kappa B (NF-κB) signalling pathway is a regulator of immune response and inflammation that has been implicated in the carcinogenic process. We examined differentially expressed genes in this pathway and miRNAs to determine associations with colorectal cancer (CRC). METHODS: We used data from 217 CRC cases to evaluate differences in NF-κB signalling pathway gene expression between paired carcinoma and normal mucosa and identify miRNAs that are associated with these genes...
November 29, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29186013/improving-the-accessibility-and-efficiency-of-point-of-care-diagnostics-services-in-low-and-middle-income-countries-lean-and-agile-supply-chain-management
#15
REVIEW
Desmond Kuupiel, Vitalis Bawontuo, Tivani P Mashamba-Thompson
Access to point-of-care (POC) diagnostics services is essential for ensuring rapid disease diagnosis, management, control, and surveillance. POC testing services can improve access to healthcare especially where healthcare infrastructure is weak and access to quality and timely medical care is a challenge. Improving the accessibility and efficiency of POC diagnostics services, particularly in resource-limited settings, may be a promising route to improving healthcare outcomes. In this review, the accessibility of POC testing is defined as the distance/proximity to the nearest healthcare facility for POC diagnostics service...
November 29, 2017: Diagnostics
https://www.readbyqxmd.com/read/29182895/efficacy-of-downhill-running-training-for-improving-muscular-and-aerobic-performances
#16
Junichi Toyomura, Hisashi Mori, Kota Tayashiki, Masayoshi Yamamoto, Hiroaki Kanehisa, Sumiaki Maeo
This study investigated effects of downhill (DR) versus level (LR) running training on various muscular and aerobic performances. Eighteen healthy young males conducted either DR (DR group [DRG], n = 10: -10% slope) or LR (LR group [LRG], n = 8) training at a target heart rate (HR) associated with lactate threshold (LT) for 20 min·session<sup>-1</sup>, 3 sessions·week<sup>-1</sup>, for 5 weeks. Before and after the interventions, the following variables were measured: knee extension torque (-150, -30, 0, 30, 150°·s<sup>-1</sup>), leg extension power (simultaneous hip and knee extension: 0...
November 28, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29182740/speciation-generates-mosaic-genomes-in-kangaroos
#17
Maria A Nilsson, Yichen Zheng, Vikas Kumar, Matthew J Phillips, Axel Janke
The iconic Australasian kangaroos and wallabies represent a successful marsupial radiation. However, the evolutionary relationship within the two genera, Macropus and Wallabia, is controversial: mitochondrial and nuclear genes, and morphological data have produced conflicting scenarios regarding the phylogenetic relationships, which in turn impact the classification and taxonomy. We sequenced and analyzed the genomes of eleven kangaroos to investigate the evolutionary cause of the observed phylogenetic conflict...
November 22, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29181250/the-efficacy-of-angle-matched-isokinetic-knee-flexor-and-extensor-strength-parameters-in-predicting-agility-test-performance
#18
Matt Greig, James Naylor
Background: Agility is a fundamental performance element in many sports, but poses a high risk of injury. Hierarchical modelling has shown that eccentric hamstring strength is the primary determinant of agility performance. Purpose: The purpose of this study was to investigate the relationship between knee flexor and extensor strength parameters and a battery of agility tests. Study Design: Controlled laboratory study. Methods: Nineteen recreational intermittent games players completed an agility battery and isokinetic testing of the eccentric knee flexors (eccH) and concentric knee extensors (conQ) at 60, 180 and 300°·s-1...
October 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29171340/measurement-properties-and-feasibility-of-the-loughborough-soccer-passing-test-a-systematic-review
#19
Daizong Wen, Sam Robertson, Guopeng Hu, Benhao Song, Haichun Chen
The purpose of this paper was to systematically review the literature and examine the research methodological quality, measurement properties and feasibility of the Loughborough Soccer Passing Test (LSPT). Databases were searched up to June 2017. Twenty five studies fulfilled the eligibility criteria. The main methodological limitations of the studies were the small sample size and the lack of information on participants and eligibility criteria. Results showed that test-retest reliability of the LSPT was moderate to excellent...
November 24, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29170044/differential-gene-expression-in-mycobacterium-bovis-challenged-monocyte-derived-macrophages-of-cattle
#20
Sanjeev Kumar Shukla, Shubhra Shukla, Anuj Chauhan, Sarvjeet, Rehan Khan, Lakshya Veer Singh, Naveen Sharma, Chandan Prakash, Ajay Vir Singh, Manjit Panigrahi
A functional genomics approach was used to examine the immune response for transcriptional profiling of PBMC M. bovis infected cattle and healthy control cattle to stimulation with bovine tuberculin (purified protein derivative PPD-b). Total cellular RNA was extracted from non-challenged control and M. bovis challenged MDM for all animals at intervals of 6 h post-challenge, in response to in-vitro challenge with M. bovis (multiplicity of infection 2:1) and prepared for global gene expression analysis using the Agilent Bovine (V2) Gene Expression Microarray, 8 × 60 K...
November 20, 2017: Microbial Pathogenesis
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