keyword
MENU ▼
Read by QxMD icon Read
search

Agility

keyword
https://www.readbyqxmd.com/read/29677166/in-vitro-identification-of-new-transcriptomic-and-mirnomic-profiles-associated-with-pulmonary-fibrosis-induced-by-high-doses-everolimus-looking-for-new-pathogenetic-markers-and-therapeutic-targets
#1
Simona Granata, Gloria Santoro, Valentina Masola, Paola Tomei, Fabio Sallustio, Paola Pontrelli, Matteo Accetturo, Nadia Antonucci, Pierluigi Carratù, Antonio Lupo, Gianluigi Zaza
The administration of Everolimus (EVE), a mTOR inhibitor used in transplantation and cancer, is often associated with adverse effects including pulmonary fibrosis. Although the underlying mechanism is not fully clarified, this condition could be in part caused by epithelial to mesenchymal transition (EMT) of airway cells. To improve our knowledge, primary bronchial epithelial cells (BE63/3) were treated with EVE (5 and 100 nM) for 24 h. EMT markers (α-SMA, vimentin, fibronectin) were measured by RT-PCR. Transepithelial resistance was measured by Millicell-ERS ohmmeter...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29672352/association-of-activities-of-daily-living-with-the-load-during-step-ascent-motion-in-nursing-home-residing-elderly-individuals
#2
Mitsuhiro Masaki, Tome Ikezoe, Midori Kamiya, Kojiro Araki, Ryo Isono, Takehiro Kato, Ken Kusano, Masayo Tanaka, Syunsuke Sato, Tetsuya Hirono, Kiyoshi Kita, Tadao Tsuboyama, Noriaki Ichihashi
OBJECTIVE: This study aimed to examine the association of independence in ADL with the loads during step ascent motion and other motor functions in 32 nursing home-residing elderly individuals. DESIGN: Independence in ADL was assessed by using the functional independence measure (FIM). The loads at the upper (i.e., pulling up) and lower (i.e., pushing up) levels during step ascent task was measured on a step ascent platform. Hip extensor, knee extensor, plantar flexor muscle, and quadriceps setting strengths; lower extremity agility using the stepping test; and hip and knee joint pain severities were measured...
April 19, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29671042/hyperbaric-oxygen-therapy-reduces-astrogliosis-and-helps-to-recovery-brain-damage-in-hydrocephalic-young-rats
#3
Stephanya Covas da Silva, Omar Feres, Pâmella da Silva Beggiora, Hélio Rubens Machado, Rafael Menezes-Reis, João Eduardo Araújo, Ricardo Andrade Brandão, Luiza da Silva Lopes
PURPOSE: We investigated the possible beneficial effects that hyperbaric oxygen therapy could offer in different brain structures affected by ventriculomegaly in pup rats submitted to experimental hydrocephalus. METHODS: Seven-day-old Wistar rats were submitted to hydrocephalus by intracisternal injection of 10% kaolin into the cisterna magna. The animals were divided into four groups: control (n = 5); control with HBOT (3ATA/2 h/day) (n = 5); untreated hydrocephalic (n = 10); hydrocephalic treated with HBOT (3ATA/2 h/day) (n = 10)...
April 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29670343/effect-of-6-month-community-based-exercise-interventions-on-gait-and-functional-fitness-of-an-older-population-a-quasi-experimental-study
#4
Fátima Ramalho, Rita Santos-Rocha, Marco Branco, Vera Moniz-Pereira, Helô-Isa André, António P Veloso, Filomena Carnide
Background: Gait ability in older adults has been associated with independent living, increased survival rates, fall prevention, and quality of life. There are inconsistent findings regarding the effects of exercise interventions in the maintenance of gait parameters. Objectives: The aim of the study was to analyze the effects of a community-based periodized exercise intervention on the improvement of gait parameters and functional fitness in an older adult group compared with a non-periodized program...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29668788/evaluation-of-the-responsiveness-index-of-the-family-health-strategy-in-rural-areas
#5
Helena Eri Shimizu, Josélia de Souza Trindade, Monique Santos de Mesquita, Maíra Catharina Ramos
Objective To evaluate the responsiveness of Family Health Strategy units in the rural area of the Federal District registered in the National Program for Improvement of Access and Quality of Basic Care. Method Descriptive study, which used a questionnaire to evaluate the following dimensions: a) respect for people: dignity, confidentiality of information, autonomy, communication; b) customer orientation: facilities, choice of the professional, agile service and social support. Results The users' assessment of responsiveness was 0...
2018: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29668045/when-does-the-influence-of-maturation-on-anthropometric-and-physical-fitness-characteristics-increase-and-subside
#6
Christopher Towlson, Stephen Cobley, Guy Parkin, Ric Lovell
The relationships between maturation and anthropometric and physical performance characteristics are dynamic and often asynchronous; confounding the capability to accurately evaluate performance during adolescence. This study aimed to (i) examine the influence of chronological age (CA) and somatic maturation (YPHV) upon anthropometric and physical performance parameters, and (ii) identify the transition/change time-points in these relationships using segmental regression. N=969 soccer players (8-18 years of age) completed anthropometric and physical test assessments, including a counter-movement jump (CMJ), agility T-test, 10 and 20m sprints, and multi-stage fitness test (MSFT)...
April 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29666409/exposure-to-phthalate-an-endocrine-disrupting-chemical-alters-the-first-trimester-placental-methylome-and-transcriptome-in-women
#7
N M Grindler, L Vanderlinden, R Karthikraj, K Kannan, S Teal, A J Polotsky, T L Powell, I V Yang, T Jansson
Phthalates are known endocrine disruptors and associated with decreased fecundity, pregnancy loss, and adverse obstetrical outcomes, however the underlying mechanisms remain to be established. Environmental factors can influence gene expression and cell function by modifying epigenetic marks, impacting the developing embryo as well as future generations of offspring. The impact of phthalates on placental gene methylation and expression is largely unknown. We studied the effect of maternal phthalate exposure on the human placental DNA methylome and transcriptome...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29659003/state-of-science-bridging-the-science-practice-gap-in-aging-dementia-and-mental-health
#8
Christopher M Callahan, Daniel R Bateman, Sophia Wang, Malaz A Boustani
The workforce available to care for older adults has not kept pace with the need. In response to workforce limitations and the growing complexity of healthcare, scientists have tested new models of care that redesign clinical practice. This article describes why new models of care in aging, dementia, and mental health diffuse inadequately into the healthcare systems and communities where they might benefit older adults. We review a general framework for the diffusion of innovations and highlight the importance of other features of innovations that deter or facilitate diffusion...
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29656083/rapid-determination-of-3-4-dimethoxy-flavonol-3-%C3%AE-d-glucopyranoside-in-rat-plasma-by-lc-ms-ms-method-followed-by-protein-precipitation
#9
Qiong Lou, Jun Wen, Yuanying Jiang, Jinghua Huang, Guorong Fan, Fenyun Song
A reliable liquid chromatography/tandem mass (LC-MS/MS) method was developed for quantitation of 3', 4'-dimethoxy flavonol-3-β-d-glucopyranoside (DF3G) in rat plasma using pantoprazole as the internal standard. An Agilent C18 column (100 mm × 3 mm, 3.5 μm) was performed for chromatographic separation with the mobile phase composed of methanol-water (containing formic acid) at a flow rate of 0.4 mL/min. A triple-quadrupole mass spectrometry equipped with an electrospray ionization (ESI) source in positive ion mode was applied to quantitative analysis by multiple reacting monitoring (MRM)...
April 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29650552/hackathons-as-a-means-of-accelerating-scientific-discoveries-and-knowledge-transfer
#10
Amel Ghouila, Geoffrey Henry Siwo, Jean-Baka Domelevo Entfellner, Sumir Panji, Katrina A Button-Simons, Sage Zenon Davis, Faisal M Fadlelmola, Michael T Ferdig, Nicola Mulder
Scientific research plays a key role in the advancement of human knowledge and pursuit of solutions to important societal challenges. Typically, research occurs within specific institutions where data are generated and subsequently analyzed. Although collaborative science bringing together multiple institutions is now common, in such collaborations the analytical processing of the data is often performed by individual researchers within the team, with only limited internal oversight and critical analysis of the workflow prior to publication...
April 12, 2018: Genome Research
https://www.readbyqxmd.com/read/29649207/physics-based-simulations-of-aerial-attacks-by-peregrine-falcons-reveal-that-stooping-at-high-speed-maximizes-catch-success-against-agile-prey
#11
Robin Mills, Hanno Hildenbrandt, Graham K Taylor, Charlotte K Hemelrijk
The peregrine falcon Falco peregrinus is renowned for attacking its prey from high altitude in a fast controlled dive called a stoop. Many other raptors employ a similar mode of attack, but the functional benefits of stooping remain obscure. Here we investigate whether, when, and why stooping promotes catch success, using a three-dimensional, agent-based modeling approach to simulate attacks of falcons on aerial prey. We simulate avian flapping and gliding flight using an analytical quasi-steady model of the aerodynamic forces and moments, parametrized by empirical measurements of flight morphology...
April 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29644532/methamphetamine-induces-apoptosis-of-microglia-via-the-intrinsic-mitochondrial-dependent-pathway
#12
Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahajan
Methamphetamine (METH) is a drug of abuse, the acute and chronic use of which induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Our goals were to understand the impact of METH on microglial mitochondrial respiration and to determine whether METH induces the activation of the mitochondrial-dependent intrinsic apoptosis pathway in microglia. We assessed the expression of pro- apoptosis genes using qPCR of RNA extracted from a human microglial cell line (HTHU). We examined the apoptosis-inducing effects of METH on microglial cells using digital holographic microscopy (DHM) to quantify real-time apoptotic volume decrease (AVD) in microglia in a noninvasive manner...
April 11, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29625360/correlation-between-quadriceps-and-hamstrings-inter-limb-strength-asymmetry-with-change-of-direction-and-sprint-in-u21-elite-soccer-players
#13
Giuseppe Coratella, Marco Beato, Federico Schena
The aim of this study was to investigate the relationship between in quadriceps and hamstrings inter-limb strength asymmetry and change of direction, sprinting and jumping abilities in U21 elite soccer players. Twenty-seven soccer players volunteered for this study. Isokinetic quadriceps and hamstrings peak torque was measured at high and low angular velocities, both in concentric and eccentric modalities. Performance in agility T-test, 20 + 20 m shuttle-test, 10 m and 30 m sprint, squat jump (SJ) and counter-movement jump (CMJ), were measured...
April 3, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29625345/toward-an-adverse-outcome-pathway-for-impaired-growth-mitochondrial-dysfunction-impairs-growth-in-early-life-stages-of-the-fathead-minnow-pimephales-promelas
#14
Derek G Bolser, David A Dreier, Erchao Li, Kevin J Kroll, Christopher J Martyniuk, Nancy D Denslow
Chemical contaminants present in the environment can affect mitochondrial bioenergetics in aquatic organisms and can have substantial effects on individual fitness. As early life stages of fish are particularly vulnerable to environmental contaminants, they are ideal models for examining the relationship between impaired mitochondrial bioenergetics (ATP-dependent respiration, basal oxidative respiration) and apical endpoints such as growth. Here, early life stages of the fathead minnow (Pimephales promelas), an ecologically relevant North American species, were used to investigate the relationship between mitochondrial bioenergetics and growth following perturbation with model mitochondrial toxicants 2,4-dinitrophenol and octylamine...
April 3, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29622786/informed-an-incubator-at-the-us-fda-for-driving-innovations-in-data-science-and-agile-technology
#15
Sean Khozin, Richard Pazdur, Anand Shah
No abstract text is available yet for this article.
April 6, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29622014/consumption-of-meat-in-relation-to-physical-functioning-in-the-seniors-enrica-cohort
#16
Ellen A Struijk, José R Banegas, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia
BACKGROUND: Meat is an important source of high-quality protein and vitamin B but also has a relatively high content of saturated and trans fatty acids. Although protein and vitamin B intake seems to protect people from functional limitations, little is known about the effect of habitual meat consumption on physical function. The objective of this study was to examine the prospective association between the intake of meat (processed meat, red meat, and poultry) and physical function impairment in older adults...
April 5, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29615826/-optimization-of-the-method-for-the-determination-of-diethyl-sulfate-at-workplaces
#17
Joanna Kowalska, Anna Jeżewska
BACKGROUND: Diethyl sulfate (DES) is a substance classified to the group of carcinogens. The value of maximum admissible concentration for this substance in workplace air is not specified in Poland. Due to the use of DES in domestic companies there is a need to develop a sensitive method for the determination of diethyl sulfate in the work environment. MATERIAL AND METHODS: Studies were performed using gas chromatography (GC) technique. An Agilent Technologies chromatograph, series 7890A, with a mass selective detector (5975C, Agilent Technologies, USA) was used in the experiment...
April 4, 2018: Medycyna Pracy
https://www.readbyqxmd.com/read/29609290/all-optical-and-broadband-microwave-fundamental-sub-harmonic-i-q-down-converters
#18
Yongsheng Gao, Aijun Wen, Wei Jiang, Yangyu Fan, You He
Microwave I/Q down-converters are frequently used in image-reject super heterodyne receivers, zero intermediate frequency (zero-IF) receivers, and phase/frequency discriminators. However, due to the electronic bottleneck, conventional microwave I/Q mixers face a serious bandwidth limitation, I/Q imbalance, and even-order distortion. In this paper, photonic microwave fundamental and sub-harmonic I/Q down-converters are presented using a polarization division multiplexing dual-parallel Mach-Zehnder modulator (PDM-DPMZM)...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29606199/gps-identified-vulnerabilities-of-savannah-woodland-primates-to-leopard-predation-and-their-implications-for-early-hominins
#19
Lynne A Isbell, Laura R Bidner, Eric K Van Cleave, Akiko Matsumoto-Oda, Margaret C Crofoot
Predation is thought to have been a key selection pressure in primate evolution, especially in the savannah-woodland habitats where several early hominin species lived. However, predator-primate prey relationships are still poorly understood because human presence often deters predators, limiting our ability to quantify the impact of predation. Synchronized high-resolution tracking of leopards (Panthera pardus), vervets (Chlorocebus pygerythrus), and olive baboons (Papio anubis) during a 14-month study in Kenya revealed that increased vulnerability to leopard predation was not associated with higher encounter rates, smaller body size, smaller group size, or greater distance from refuges, contrary to long-standing inferences...
May 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29597228/sexual-behaviour-of-the-spectral-tarsier-tarsius-spectrum-in-captivity
#20
Nanik Hidayatik, Tuty Laswardi Yusuf, Muhammad Agil, Entang Iskandar, Dondin Sajuthi
Tarsius spectrum is a primate species endemic to Sulawesi. Populations of the species have decreased due to habitat destruction and hunting. The sexual behaviour of T. bancanus and T. syrichta are known, but that of T. spectrum has not been reported until recently. The aim of this research was to study the sexual behaviour of T. spectrum in captivity. We observed 3 pairs of T. spectrum at the captive breeding facility of the IPB Primate Research Centre for 9 months using focal animal sampling. We showed that principal courtship behaviours were scent marking (36...
March 29, 2018: Folia Primatologica; International Journal of Primatology
keyword
keyword
17725
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"