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https://www.readbyqxmd.com/read/29443905/a-comparison-of-military-and-law-enforcement-body-armour
#1
Robin Orr, Ben Schram, Rodney Pope
Law-enforcement officers increasingly wear body armour for protection; wearing body armour is common practice in military populations. Law-enforcement and military occupational demands are vastly different and military-styled body armour may not be suitable for law-enforcement. This study investigated differences between selected military body armour (MBA: 6.4 kg) and law-enforcement body armour (LEBA: 2.1 kg) in impacts on postural sway, vertical jump, agility, a functional movement screen (FMS), task simulations (vehicle exit; victim recovery), and subjective measures...
February 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29439237/morphology-muscle-capacity-skill-and-maneuvering-ability-in-hummingbirds
#2
Roslyn Dakin, Paolo S Segre, Andrew D Straw, Douglas L Altshuler
How does agility evolve? This question is challenging because natural movement has many degrees of freedom and can be influenced by multiple traits. We used computer vision to record thousands of translations, rotations, and turns from more than 200 hummingbirds from 25 species, revealing that distinct performance metrics are correlated and that species diverge in their maneuvering style. Our analysis demonstrates that the enhanced maneuverability of larger species is explained by their proportionately greater muscle capacity and lower wing loading...
February 9, 2018: Science
https://www.readbyqxmd.com/read/29437004/therapeutic-drug-monitoring-of-phenytoin-by-simple-rapid-accurate-highly-sensitive-and-novel-method-and-its-clinical-applications
#3
Abdul Sami Shaikh, Ruichen Guo
BACKGROUND: Phenytoin has very challenging pharmacokinetic properties. To prevent its toxicity and ensure efficacy, continuous therapeutic monitoring is required. It is hard to get a simple, accurate, rapid, easily available, economical and highly sensitive assay in one method for therapeutic monitoring of phenytoin. OBJECTIVE: The present study is directed towards establishing and validating a more simple, rapid, an accurate, highly sensitive, novel and environment friendly liquid chromatography/mass spectrometry (LC/MS) method for offering rapid and reliable TDM results of phenytoin in epileptic patients to physicians and clinicians for making immediate and rational decision...
February 9, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29434446/hsa-mir-202-3p-up-regulated-in-type-1-gastric-neuroendocrine-neoplasms-may-target-dusp1
#4
Dou Dou, Yan-Fen Shi, Qing Liu, Jie Luo, Ji-Xi Liu, Meng Liu, Ying-Ying Liu, Yuan-Liang Li, Xu-Dong Qiu, Huang-Ying Tan
AIM: To detect abnormal microRNA (miRNA) expression in type 1 gastric neuroendocrine neoplasms (g-NENs) and find potential target genes. METHODS: Tumour tissues from patients with type 1 g-NENs were used as experimental samples, and gastric mucosal tissues from the same patients obtained during gastroscopy review after several months were used as control samples. miRNA expression was examined with Agilent human miRNA chips and validated via RT-PCR. Three types of target gene prediction software (TargetScan, PITA, and microRNAorg) were used to predict potential target genes of the differentially expressed miRNAs, and a dual-luciferase reporter assay system was used for verification...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29431556/the-fit-matters-influence-of-accelerometer-fitting-and-training-drill-demands-on-load-measures-in-rugby-league-players
#5
Blake D McLean, Cloe Cummins, Greta Conlan, Grant Duthie, Aaron J Coutts
PURPOSE: Determine the relationship between drill type and accelerometer-derived loads during various team sport activities, and examine the influence of unit fitting on these loads. METHODS: Sixteen rugby league players were fitted with microtechnology devices in either manufacturer vests or playing jerseys before completing standardised running, agility and tackling drills. Two-dimensional (2D) and three-dimensional (3D) accelerometer loads (BodyLoadTM) per km were compared across drills and fittings (i...
February 12, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29430940/positive-effects-of-a-short-term-intense-elastic-resistance-training-program-on-body-composition-and-physical-functioning-in-overweight-older-women
#6
Nicole B Fritz, Álvaro Juesas, Pedro Gargallo, Joaquín Calatayud, Julio Fernández-Garrido, Michael E Rogers, Juan C Colado
The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices. METHODS: This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no medical history of disease that would preclude them from engaging in physical exercise. Participants were randomly divided into the following groups: elastic tubes with handles group (ETG; n = 22), traditional elastic bands group ( n = 21), and control group (CG; n = 20)...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29429140/comparison-of-fecal-preservation-and-extraction-methods-for-steroid-hormone-metabolite-analysis-in-wild-crested-macaques
#7
Gholib Gholib, Michael Heistermann, Muhammad Agil, Iman Supriatna, Bambang Purwantara, Taufiq Purna Nugraha, Antje Engelhardt
Since the non-invasive field endocrinology techniques were developed, several fecal preservation and extraction methods have been established for a variety of species. However, direct adaptation of methods from previous studies for use in crested macaques should be taken with caution. We conducted an experiment to assess the accuracy and stability of fecal estrogen metabolite (E1C) and glucocorticoid metabolite (GCM) concentrations in response to several preservation parameters: (1) time lag between sample collection and fecal preservation; (2) long-term storage of fecal samples in 80% methanol (MeOH) at ambient temperature; (3) different degrees of feces drying temperature using a conventional oven; and (4) different fecal preservation techniques (i...
February 10, 2018: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/29423798/whole-exome-library-construction-for-next-generation-sequencing
#8
Winnie S Liang, Kristi Stephenson, Jonathan Adkins, Austin Christofferson, Adrienne Helland, Lori Cuyugan, Jonathan J Keats
Whole exome sequencing (WES) is a DNA sequencing strategy that provides a survey of base substitutions across coding genomic locations and other regions of interest. As the coding portion of the genome encompasses only 1-2% of the entire genome, this approach represents a more cost-effective strategy to detect DNA alterations that may alter protein function, compared to whole genome sequencing. Although the research community has and is currently delineating the functional implications of sequence changes in noncoding regions of the genome, WES is a currently available assay that provides valuable information for both discovery research and precision medicine applications...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29421905/feed-forward-coherent-link-from-a-comb-to-a-diode-laser-application-to-widely-tunable-cavity-ring-down-spectroscopy
#9
Riccardo Gotti, Marco Prevedelli, Samir Kassi, Marco Marangoni, Daniele Romanini
We apply a feed-forward frequency control scheme to establish a phase-coherent link from an optical frequency comb to a distributed feedback (DFB) diode laser: This allows us to exploit the full laser tuning range (up to 1 THz) with the linewidth and frequency accuracy of the comb modes. The approach relies on the combination of an RF single-sideband modulator (SSM) and of an electro-optical SSM, providing a correction bandwidth in excess of 10 MHz and a comb-referenced RF-driven agile tuning over several GHz...
February 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29421849/a-validated-liquid-chromatography-tandem-mass-spectrometry-method-for-the-analysis-of-efavirenz-in-0-2-mg-hair-samples-from-hiv-infected-patients
#10
Jenna Johnston, Catherine Orrell, Peter Smith, Anton Joubert, Lubbe Wiesner
RATIONALE: Drug levels in hair provide a longer window of detection, compared to plasma drug levels, and therefore hair analysis has the advantage of assessing adherence over a longer period of time. No methods for the analysis of antiretroviral drugs in hair currently exist in South Africa, and worldwide there is only one validated method for the determination of efavirenz in hair that has been published. METHODS: Efavirenz was extracted from 0.2 mg of hair through a simultaneous pulverization and extraction step...
February 8, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29420813/sport-psychology-for-the-soldier-athlete-a-paradigm-shift
#11
Vanessa M Meyer
Background: Competitive athletes train body and mind in preparation for competition with mental fortitude often providing the "winning edge." Similarly, the current-day warfighter faces significant physical and psychological challenges and must be prepared to respond to life-threatening danger with mental and physical agility. Sport Psychology for the Soldier Athlete recognizes the soldier as an elite athlete and provides training required to perform at the highest caliber. Through this curriculum, mental skills coaching in goal setting, imagery, positive self-talk, and heart rate control is integrated into routine physical fitness training...
February 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29420390/specific-adaptations-in-performance-and-muscle-architecture-after-weighted-jump-squat-vs-body-mass-squat-jump-training-in-recreational-soccer-players
#12
Giuseppe Coratella, Marco Beato, Chiara Milanese, Stefano Longo, Eloisa Limonta, Susanna Rampichini, Emiliano Cè, Angela Valentina Bisconti, F Schena, F Esposito
The aim of the present study was to compare the effects of weighted jump squat (WJST) vs body mass squat jump training (BMSJT) on quadriceps muscle architecture, lower-limb lean-mass (LM) and muscle strength, performance in change of direction (COD), sprint and jump in recreational soccer-players. Forty-eight healthy soccer-players participated in an off-season randomized controlled-trial. Before and after an eight-week training intervention, vastus lateralis pennation angle, fascicle length, muscle thickness, LM, squat 1-RM, quadriceps and hamstrings isokinetic peak-torque, agility T-test, 10 and 30m sprint and squat-jump (SJ) were measured...
February 6, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29416948/fit-for-duty-evaluating-the-physical-fitness-requirements-of-battlefield-airmen
#13
Robson Sean, Lytell Maria C, Sims Carra S, Pezard Stephanie, Manacapilli Thomas, Anderson Amanda, Bohusch Therese, Haddad Abigail
Military occupations can be physically demanding, yet few attempts have been made to determine the physical readiness of today's airmen to perform their jobs. Although the Air Force conducts fitness testing of all its airmen, these tests and standards are not based on validated job requirements. As part of a broader Air Force effort to measure the physical readiness of airmen to perform their jobs, this study describes a methodology for establishing physical fitness standards for four physically demanding Air Force occupational specialties-combat controller, pararescue, special operations weather team, and tactical air control party...
January 2018: Rand Health Quarterly
https://www.readbyqxmd.com/read/29416641/pd-l1-cd274-and-pd-l2-pdcd1lg2-promoter-methylation-is-associated-with-hpv-infection-and-transcriptional-repression-in-head-and-neck-squamous-cell-carcinomas
#14
Alina Franzen, Timo J Vogt, Tim Müller, Jörn Dietrich, Andreas Schröck, Carsten Golletz, Peter Brossart, Friedrich Bootz, Jennifer Landsberg, Glen Kristiansen, Dimo Dietrich
Background: DNA methylation of the immune checkpoint gene PD-L1 has recently been shown to be associated with PD-L1 mRNA expression in various malignancies. This study aimed to investigate the association of PD-L1 and PD-L2 methylation with mRNA expression, immune cell infitration, protein expression and human papilloma virus (HPV) infection in head and neck squamous cell carcinoma (HNSCC) patients. Results: DNA methylation of PD-L1 and PD-L2 correlates inversely with mRNA expression (PD-L1: p ≤ 0...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29411526/assessment-of-multi-criteria-optimization-mco-for-volumetric-modulated-arc-therapy-vmat-in-hippocampal-avoidance-whole-brain-radiation-therapy-ha-wbrt
#15
Stephen Zieminski, Melin Khandekar, Yi Wang
This study compared the dosimetric performance of (a) volumetric modulated arc therapy (VMAT) with standard optimization (STD) and (b) multi-criteria optimization (MCO) to (c) intensity modulated radiation therapy (IMRT) with MCO for hippocampal avoidance whole brain radiation therapy (HA-WBRT) in RayStation treatment planning system (TPS). Ten HA-WBRT patients previously treated with MCO-IMRT or MCO-VMAT on an Elekta Infinity accelerator with Agility multileaf collimators (5-mm leaves) were re-planned for the other two modalities...
February 7, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29408208/effect-of-glucocorticoids-on-mirna-expression-spectrum-of-rat-femoral-head-microcirculation-endothelial-cells
#16
Ju'an Yue, Fuyin Wan, Qidong Zhang, Pengfei Wen, Liming Cheng, Ping Li, Wanshou Guo
The study profiled the differential miRNA expression from femoral head bone microvascular endothelial cells (BMECs) between model group and control group to explore the pathogenesis of steroid-induced osteonecrosis of femoral head (ONFH). Twenty 8-week-old Female Sprague-Dawley (SD) rats were randomly divided into control and model groups. Rats in model group received an intraperitoneal injection of 20-μg/kg lipopolysaccharide (LPS) at an interval of 24 h. Then, 24 h later, rats received three doses of 40-mg/kg methylprednisolone by intramuscular injection at intervals of 24 h...
February 2, 2018: Gene
https://www.readbyqxmd.com/read/29405796/running-in-people-with-cerebral-palsy-a-systematic-review
#17
Annie Chappell, Noula Gibson, Susan Morris, Gavin Williams, Garry T Allison
BACKGROUND: Running is a fundamental motor skill which is important for participation in recreational activities throughout the lifespan. AIM: To identify, appraise, and synthesize the evidence related to running in people with cerebral palsy (CP). METHOD: A search of electronic databases was conducted in April 2016. Articles were reviewed by two assessors and had to meet the following criteria: 1) population included people with CP; and 2) included information about running...
February 6, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29405372/melatonin-increases-brown-adipose-tissue-mass-and-function-in-z%C3%A3-cker-diabetic-fatty-rats-implications-for-obesity-control
#18
Gumersindo Fernández Vázquez, Russel J Reiter, Ahmad Agil
Melatonin limits obesity in rodents without affecting food intake and activity, suggesting a thermogenic effect. Previously we demonstrated that melatonin browns subcutaneous fat in Zücker diabetic fatty (ZDF) rats. Other works pointed to melatonin as a signal that increases brown adipose tissue (BAT) mass and function in rodents. However, direct proof of thermogenic properties (uncoupled mitochondria) of the newly recruited BAT in response to melatonin is still lacking. Therefore, in the present work we investigated if melatonin recruits thermogenic BAT in ZDF rats...
February 6, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29404866/differential-expression-of-the-pal-gene-family-in-rice-seedlings-exposed-to-chromium-by-microarray-analysis
#19
Xiao-Zhang Yu, Wei-Jia Fan, Yu-Juan Lin, Fei-Fei Zhang, Dharmendra K Gupta
Phenylalanine ammonia-lyase (PAL) is one of the principle enzymes involved in plant's secondary metabolism. Expression of individual isogene from the PAL gene family is variable with species of plants in responses to different stresses. In this study, transcriptome analysis of the PAL gene family in rice seedlings exposed to potassium chromate Cr(VI) or chromium nitrate Cr(III) was conducted using Agilent 44K rice microarray and real-time quantitative RT-PCR. Uptake and accumulation of both Cr species by rice seedlings and their effect on PAL activity were also determined...
February 5, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29401822/5-gbps-wireless-transmission-link-with-an-optically-pumped-uni-traveling-carrier-photodiode-mixer-at-the-receiver
#20
Ahmad W Mohammad, Haymen Shams, Katarzyna Balakier, Chris Graham, Michele Natrella, Alwyn J Seeds, Cyril C Renaud
We report the first demonstration of a uni-traveling carrier photodiode (UTC-PD) used as a 5 Gbps wireless receiver. In this experiment, a 35.1 GHz carrier was electrically modulated with 5 Gbps non-return with zero on-off keying (NRZ-OOK) data and transmitted wirelessly over a distance of 1.3 m. At the receiver, a UTC-PD was used as an optically pumped mixer (OPM) to down-convert the received radio frequency (RF) signal to an intermediate frequency (IF) of 11.7 GHz, before it was down-converted to the baseband using an electronic mixer...
February 5, 2018: Optics Express
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