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https://www.readbyqxmd.com/read/28820847/effectiveness-of-a-16-week-high-intensity-cardioresistance-training-program-in-adults
#1
Tina A Greenlee, Daniel R Greene, Nathan J Ward, Ginger E Reeser, Courtney M Allen, Nicholas W Baumgartner, Neal J Cohen, Arthur F Kramer, Charles H Hillman, Aron K Barbey
Greenlee, TA, Greene, DR, Ward, NJ, Reeser, GE, Allen, CM, Baumgartner, NW, Cohen, NJ, Kramer, AF, Hillman, CH, and Barbey, AK. Effectiveness of a 16-week high-intensity cardioresistance training program in adults. J Strength Cond Res 31(9): 2528-2541, 2017-The purpose of this study was to determine the efficacy of a novel, 16-week high-intensity cardioresistance training (HICRT) program on measures of aerobic fitness, agility, aerobic power, muscular endurance, lower-body explosive power, and self-reported activity level...
September 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28818609/multicenter-comparison-of-22c3-pharmdx-agilent-and-sp263-ventana-assays-to-test-pd-l1-expression-for-nsclc-patients-to-be-treated-with-immune-checkpoint-inhibitors
#2
Antonio Marchetti, Massimo Barberis, Renato Franco, Graziano De Luca, Maria Vittoria Pace, Stefania Staibano, Marco Volante, Fiamma Buttitta, Elena Guerini-Rocco, Luisella Righi, Tommaso D'antuono, Giorgio V Scagliotti, Carmine Pinto, Gaetano De Rosa, Mauro Papotti
INTRODUCTION: Among the several agents targeting the programmed cell death 1 (PD-1) pathway, pembrolizumab is currently the only one approved for the treatment of non-small cell lung cancer patients in association with a companion diagnostic assay, the anti-programmed cell death ligand 1 (PD-L1) immunohistochemical (IHC) 22C3 PharmDx (Agilent) using the Dako Autostainer. However, the Dako platform is not present in each pathology department and this technical limitation is a major problem for the diffusion of the PD-L1 IHC predictive test for pembrolizumab...
August 14, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28816503/pubertal-development-of-body-size-and-soccer-specific-functional-capacities-in-adolescent-players
#3
Humberto Moreira Carvalho, José A Lekue, Susana M Gil, Iraia Bidaurrazaga-Letona
Pubertal growth in body size and functional capacities were examined in adolescent soccer players (n = 33). The average age at baseline was 10.9 (9.8-11.8 years). Peak height velocity (PHV) and growth curves for body mass and functional performance (countermovement jump, 15-m sprint, agility and Yo-Yo intermittent recovery test - level 1) were determined with Bayesian multilevel models. Estimates for PHV and age at PHV were 8.1 cm/year (95% credible interval: 4.2-18.5 cm/year) and 12.9 years (95% credible interval: 11...
August 17, 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/28814844/comparison-between-parameters-of-muscle-performance-and-inflammatory-biomarkers-of-non-sarcopenic-and-sarcopenic-elderly-women
#4
Lygia Paccini Lustosa, Patrícia Parreira Batista, Daniele Sirineu Pereira, Leani Souza Máximo Pereira, Aline Scianni, Giane Amorim Ribeiro-Samora
BACKGROUND: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function. OBJECTIVE: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer) and plasma levels of interleukin-6 (IL-6) and soluble receptors of tumor necrosis factor alpha (sTNFR1) between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28814435/adaptive-global-innovative-learning-environment-for-glioblastoma-gbm-agile
#5
Brian M Alexander, Sujuan Ba, Mitchel S Berger, Donald A Berry, Webster K Cavenee, Susan M Chang, Timothy F Cloughesy, Tao Jiang, Mustafa Khasraw, Wenbin Li, Robert Mittman, George H Poste, Patrick Y Wen, W K Alfred Yung, Anna D Barker
Glioblastoma (GBM) is a deadly disease with few effective therapies. While much has been learned about the molecular characteristics of the disease, this knowledge has not been translated into clinical improvements for patients. At the same time, many new therapies are being developed. Many of these therapies have potential biomarkers to identify responders. The result is an enormous amount of testable clinical questions that must be answered efficiently. The GBM Adaptive Global Innovative Learning Environment (GBM AGILE) is a novel, multi-arm, platform trial designed to address these challenges...
August 16, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28813489/oxidative-and-glycolytic-skeletal-muscles-show-marked-differences-in-gene-expression-profile-in-chinese-qingyuan-partridge-chickens
#6
Shu Jingting, Xiao Qin, Shan Yanju, Zhang Ming, Tu Yunjie, Ji Gaige, Sheng Zhongwei, Zou Jianmin
Oxidative and glycolytic myofibers have different structures and metabolic characteristics and their ratios are important in determining poultry meat quality. However, the molecular mechanisms underlying their differences are unclear. In this study, global gene expression profiling was conducted in oxidative skeletal muscle (obtained from the soleus, or SOL) and glycolytic skeletal muscle (obtained from the extensor digitorum longus, or EDL) of Chinese Qingyuan partridge chickens, using the Agilent Chicken Gene Expression Chip...
2017: PloS One
https://www.readbyqxmd.com/read/28813431/skeleton-of-an-unusual-cat-sized-marsupial-relative-metatheria-marsupialiformes-from-the-middle-eocene-lutetian-44-43-million-years-ago-of-turkey
#7
A Murat Maga, Robin M D Beck
We describe a near-complete, three-dimensionally preserved skeleton of a metatherian (relative of modern marsupials) from the middle Eocene (Lutetian: 44-43 million years ago) Lülük member of the Uzunçarşıdere Formation, central Turkey. With an estimated body mass of 3-4 kg, about the size of a domestic cat (Felis catus) or spotted quoll (Dasyurus maculatus), it is an order of magnitude larger than the largest fossil metatherians previously known from the Cenozoic of the northern hemisphere. This new taxon is characterised by large, broad third premolars that probably represent adaptations for hard object feeding (durophagy), and its craniodental morphology suggests the capacity to generate high bite forces...
2017: PloS One
https://www.readbyqxmd.com/read/28806688/concentration-dependent-transcriptome-responses-of-zebrafish-embryos-after-exposure-to-cadmium-cobalt-and-copper
#8
Laura Sonnack, Thorsten Klawonn, Ralf Kriehuber, Henner Hollert, Christoph Schäfers, Martina Fenske
Environmental metals are known to cause harmful effects to fish of which many molecular mechanisms still require elucidation. Particularly concentration dependence of gene expression effects is unclear. Focusing on this matter, zebrafish embryo toxicity tests were used in combination with transcriptomics. Embryos were exposed to three concentrations of copper (CuSO4), cadmium (CdCl2) and cobalt (CoSO4) from just after fertilization until the end of the 48hpf pre- and 96hpf post-hatch stage. The RNA was then analyzed on Agilent's Zebrafish (V3, 4×44K) arrays...
August 2, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28806646/static-flexural-properties-of-hedgehog-spines-conditioned-in-coupled-temperature-and-relative-humidity-environments
#9
Emily B Kennedy, Bor-Kai Hsiung, Nathan B Swift, Kwek-Tze Tan
Hedgehogs are agile climbers, scaling trees and plants to heights exceeding 10m while foraging insects. Hedgehog spines (a.k.a. quills) provide fall protection by absorbing shock and could offer insights for the design of lightweight, material-efficient, impact-resistant structures. There has been some study of flexural properties of hedgehog spines, but an understanding of how this keratinous biological material is affected by various temperature and relative humidity treatments, or how spine color (multicolored vs...
August 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28806410/the-influence-of-speed-abilities-and-technical-skills-in-early-adolescence-on-adult-success-in-soccer-a-long-term-prospective-analysis-using-anova-and-sem-approaches
#10
Oliver Höner, Daniel Leyhr, Augustin Kelava
Several talent development programs in youth soccer have implemented motor diagnostics measuring performance factors. However, the predictive value of such tests for adult success is a controversial topic in talent research. This prospective cohort study evaluated the long-term predictive value of 1) motor tests and 2) players' speed abilities (SA) and technical skills (TS) in early adolescence. The sample consisted of 14,178 U12 players from the German talent development program. Five tests (sprint, agility, dribbling, ball control, shooting) were conducted and players' height, weight as well as relative age were assessed at nationwide diagnostics between 2004 and 2006...
2017: PloS One
https://www.readbyqxmd.com/read/28802063/hepatitis-b-virus-pregenomic-rna-in-hepatocellular-carcinoma-a-nosological-and-prognostic-determinant
#11
Boris Halgand, Christophe Desterke, Lise Rivière, Guillaume Fallot, Mylène Sebagh, Julien Calderaro, Paulette Bioulac-Sage, Christine Neuveut, Marie-Annick Buendia, Didier Samuel, Cyrille Féray
Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). However, very little is known about the replication of HBV in HCC tissues. PATIENTS AND METHODS: We analysed viral and cellular parameters in HCC (T) and non-tumor liver (NT) samples from 99 HBsAg-positive, virologically suppressed patients treated by tumour resection or liver transplantation. We examined total HBV DNA and RNA as well as covalently closed circular DNA (cccDNA) and pregenomic RNA (pgRNA), which are considered as markers of active HBV replication...
August 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28798363/defining-quantification-methods-and-optimizing-protocols-for-microarray-hybridization-of-circulating-micrornas
#12
Anna Garcia-Elias, Leonor Alloza, Eulàlia Puigdecanet, Lara Nonell, Marta Tajes, Joao Curado, Cristina Enjuanes, Oscar Díaz, Jordi Bruguera, Julio Martí-Almor, Josep Comín-Colet, Begoña Benito
MicroRNAs (miRNAs) have emerged as promising biomarkers of disease. Their potential use in clinical practice requires standardized protocols with very low miRNA concentrations, particularly in plasma samples. Here we tested the most appropriate method for miRNA quantification and validated the performance of a hybridization platform using lower amounts of starting RNA. miRNAs isolated from human plasma and from a reference sample were quantified using four platforms and profiled with hybridization arrays and RNA sequencing (RNA-seq)...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795493/-molecularly-imprinted-chromatography-fails-to-distinguish-homeopatic-remedy-from-placebo
#13
Roman Kaliszan, Małgorzata Waszczuk-Jankowska, Danuta Siluk, Bartosz Wielgomas
It was sensation when Dr. J. Beneviste reported alleged experimental biological evidence of the water memory effect (E. Dayenas et al. Nature 333, 816-818, 1988; https://doi.org/10.1038/333816a0). These experiments have never been reproduced in controlled conditions, however. Instead, the hypothesis that water can be imprinted with the memory of past solutes was ruled out (J. Maddox et al. Nature 334, 287-290, 1988; https://doi.org/10.1038/334287a0). At present, so-called "molecular imprinting" is a technology of preparing polymer matrices as affinity-based analyte separation media (J...
August 10, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28789992/a-whole-brain-volumetric-approach-in-overweight-obese-children-examining-the-association-with-different-physical-fitness-components-and-academic-performance-the-activebrains-project
#14
Irene Esteban-Cornejo, Cristina Cadenas-Sanchez, Oren Contreras-Rodriguez, Juan Verdejo-Roman, Jose Mora-Gonzalez, Jairo H Migueles, Pontus Henriksson, Catherine L Davis, Antonio Verdejo-Garcia, Andrés Catena, Francisco B Ortega
Obesity, as compared to normal weight, is associated with detectable structural differences in the brain. To the best of our knowledge, no previous study has examined the association of physical fitness with gray matter volume in overweight/obese children using whole brain analyses. Thus, the aim of this study was to examine the association between the key components of physical fitness (i.e. cardiorespiratory fitness, speed-agility and muscular fitness) and brain structural volume, and to assess whether fitness-related changes in brain volumes are related to academic performance in overweight/obese children...
August 5, 2017: NeuroImage
https://www.readbyqxmd.com/read/28783470/differences-in-fitness-level-between-women-aged-60-and-over-participating-in-three-different-supervised-exercise-programs-and-a-sedentary-group
#15
Maria Viladrosa, Ana Lavedán, Pilar Jürschik, Sebastià Mas-Alòs, Antoni Planas-Anzano, Olga Masot
The aim of this study was to compare fitness levels in women aged 60 and over participating in a supervised exercise program (involving tai chi, recreational gymnastics, and/or aquatic fitness) with those in a sedentary group. An observational, descriptive, cross-sectional study was performed on a total of 171 women aged from 60 to 92 who attended public community clubs for older adults. The instruments used included the Senior Fitness Test, the Tinetti Balance Assessment Tool, the Katz Index, and the Lawton & Brody Activities of Daily Living Scale...
August 7, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28781933/effects-of-kinesio-%C3%A2-taping-on-dynamic-balance-following-fatigue-a-randomized-controlled-trial
#16
Noh Zulfikri, Maria Justine
The objective of the study was to determine the effects of Kinesio taping (KT) in inhibiting fatigue and preserving dynamic balance. Male recreational athletes were recruited to participate in this study. Participants were blinded from the group assignment and divided into four groups (Group A; KT and fatigue, Group B; no tape and fatigue, Group C; KT and no fatigue and Group D; no tape and no fatigue) using sequentially opaque, sealed envelopes. Pre and post measurements of Modified Star Excursion Balance Test (SEBT) composite score and normalized reach distance were used to measure dynamic balance...
2017: Physical Therapy Research
https://www.readbyqxmd.com/read/28777249/isometric-mid-thigh-pull-performance-is-associated-with-athletic-performance-and-sprinting-kinetics-in-division-i-men-and-women-s-basketball-players
#17
Jeremy R Townsend, David Bender, William Vantrease, John Hudy, Kevin Huet, Cassie Williamson, Emily Bechke, Paul Serafini, Gerald T Mangine
PURPOSE: To examine the relationships between isometric mid-thigh pull (IMTP) force, athletic performance measures, and sprint kinetics in Division I men's and women's basketball players. METHODS: Twenty-three (male = 8, female = 15) division 1 basketball players completed a maximal 20-m sprint trial while tethered to a device which provided kinetic feedback (peak and average sprinting power, velocity and force). Additionally, one repetition-maximal (1RM) front squat, 1RM hang clean, vertical jump height, and agility (pro-agility and lane agility) tests were performed...
July 31, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28776280/effects-of-a-10-week-multimodal-exercise-program-on-physical-and-cognitive-function-of-nursing-home-residents-a-psychomotor-intervention-pilot-study
#18
Catarina Pereira, Hugo Rosado, Ana Cruz-Ferreira, José Marmeleira
BACKGROUND: Nursing home institutionalization tends to exacerbate loss of functioning. AIMS: Examine the feasibility and the effect of a psychomotor intervention-a multimodal exercise program promoting simultaneous cognitive and motor stimulation-on the executive (planning ability and selective attention) and physical function of nursing home residents. METHODS: Seventeen participants engaged in a 10-week multimodal exercise program and 17 maintained usual activities...
August 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28771142/comparison-of-semi-automated-commercial-rep-pcr-fingerprinting-spoligotyping-12-locus-miru-vntr-typing-and-single-nucleotide-polymorphism-analysis-of-the-embb-gene-as-molecular-typing-tools-for-mycobacterium-bovis
#19
Federica Armas, Cristina Camperio, Luana Coltella, Serena Selvaggini, Maria Beatrice Boniotti, Maria Lodovica Pacciarini, Vincenzo Di Marco Lo Presti, Cinzia Marianelli
PURPOSE: Highly discriminatory genotyping strategies are essential in molecular epidemiological studies of tuberculosis. In this study we evaluated, for the first time, the efficacy of the repetitive sequence-based PCR (rep-PCR) DiversiLab Mycobacterium typing kit over spoligotyping, 12-locus mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing and embB single nucleotide polymorphism (SNP) analysis for Mycobacterium bovis typing. METHODOLOGY: A total of 49 M...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28770387/data-to-decisions-creating-a-culture-of-model-driven-drug-discovery
#20
Frank K Brown, Farida Kopti, Charlie Zhenyu Chang, Scott A Johnson, Meir Glick, Chris L Waller
Merck & Co., Inc., Kenilworth, NJ, USA, is undergoing a transformation in the way that it prosecutes R&D programs. Through the adoption of a "model-driven" culture, enhanced R&D productivity is anticipated, both in the form of decreased attrition at each stage of the process and by providing a rational framework for understanding and learning from the data generated along the way. This new approach focuses on the concept of a "Design Cycle" that makes use of all the data possible, internally and externally, to drive decision-making...
August 2, 2017: AAPS Journal
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