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https://www.readbyqxmd.com/read/29327140/children-s-experiences-of-congenital-heart-disease-a-systematic-review-of-qualitative-studies
#1
REVIEW
Lauren S H Chong, Dominic A Fitzgerald, Jonathan C Craig, Karine E Manera, Camilla S Hanson, David Celermajer, Julian Ayer, Nadine A Kasparian, Allison Tong
We aimed to describe the experiences of children and adolescents with congenital heart disease (CHD). Electronic databases were searched until August 2016. Qualitative studies of children's perspectives on CHD were included. Data was extracted using thematic synthesis. From 44 studies from 12 countries involving 995 children, we identified 6 themes: disrupting normality (denying the diagnosis, oscillating between sickness and health, destabilizing the family dynamic), powerlessness in deteriorating health (preoccupation with impending mortality, vulnerability to catastrophic complications, exhaustion from medical testing), enduring medical ordeals (traumatized by invasive procedures, disappointed by treatment failure, displaced by transition, valuing empathy and continuity in care, overcoming uncertainty with information), warring with the body (losing stamina, distressing inability to participate in sport, distorted body image, testing the limits), hampering potential and goals (feeling disabled, unfair judgment and exclusion, difficulties with academic achievement, limiting attainment and maintenance of life milestones), and establishing one's own pace (demarcating disease from life, determination to survive, taking limitations in their stride, embracing the positives, finding personal enrichment, relying on social or spiritual support)...
January 11, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29306524/the-singer-s-and-the-clinician-s-perspective-on-vitamin-b12-treatment-for-vocal-benefits
#2
Hagit Shoffel-Havakuk, Christian X Lava, Edie R Hapner, Karla O'Dell, Lindsay Reder, Michael M Johns
INTRODUCTION: There is a belief among vocalists that there are voice benefits from vitamin B12 treatment. Yet there are no previous reports regarding vitamin B12 effects on voice. OBJECTIVES: To assess the prevalence of vitamin B12 use among singers and their beliefs regarding vitamin B12 therapy. METHODS: Anonymous online survey administered to singers, singing-teachers, speech-language pathologists, and laryngologists. RESULTS: A total of 192 participants completed the surveys; 128 singers (68 singing-teachers, 30 speech-language pathologists) and 64 laryngologists...
January 3, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29274695/diminutive-porcelain-ascending-aorta-with-supravalvular-aortic-stenosis
#3
Mustafa Houmsse, Asia McDavid, Ahmet Kilic
This case report describes a case of a 49-year-old male, with a past medical history significant for congenital aortic stenosis, who presented with progressive shortness of breath and decreased stamina. The patient was found to have a concentric, diminutive porcelain ascending aorta with diffuse supravalvular aortic stenosis. Herein we describe treatment with an aortic root augmentation and Bentall procedure utilizing hypothermic circulatory arrest.
December 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29235234/-holding-on-to-life-an-ethnographic-study-of-living-well-at-home-in-old-age
#4
Kristin Bjornsdottir
In recent years, much attention has been paid to how older people living at home can remain independent and manage their illness themselves, while less attention has been given to those who have become frail and need assistance with challenges of everyday life. In this article, I drew on Latimer's formulation of care for frail older people as relational and world-making and on Foucault's work related to the care of the self in developing an understanding of how frail older persons manage to live well at home in the final years of their lives...
December 13, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/29231808/abelson-tyrosine-protein-kinase-2-regulates-myoblast-proliferation-and-controls-muscle-fiber-length
#5
Jennifer K Lee, Steven J Burden
Muscle fiber length is nearly uniform within a muscle but widely different among different muscles. We show that Abelson tyrosine-protein kinase 2 (Abl2) has a key role in regulating myofiber length, as a loss of Abl2 leads to excessively long myofibers in the diaphragm, intercostal and levator auris muscles but not limb muscles. Increased myofiber length is caused by enhanced myoblast proliferation, expanding the pool of myoblasts and leading to increased myoblast fusion. Abl2 acts in myoblasts, but as a consequence of expansion of the diaphragm muscle, the diaphragm central tendon is reduced in size, likely contributing to reduced stamina of Abl2 mutant mice...
December 12, 2017: ELife
https://www.readbyqxmd.com/read/29230698/mode-2-knowledge-production-in-the-context-of-medical-research-a-call-for-further-clarifications
#6
Hojjat Soofi
The traditional researcher-driven environment of medical knowledge production is losing its dominance with the expansion of, for instance, community-based participatory or participant-led medical research. Over the past few decades, sociologists of science have debated a shift in the production of knowledge from traditional discipline-based (Mode 1) to more socially embedded and transdisciplinary frameworks (Mode 2). Recently, scholars have tried to show the relevance of Mode 2 knowledge production to medical research...
December 11, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/29189909/behavioral-and-physiological-polymorphism-in-males-of-the-austral-lizard-liolaemus-sarmientoi
#7
Jimena B Fernández, Elizabeth Bastiaans, Marlin Medina, Fausto R Méndez De la Cruz, Barry R Sinervo, Nora R Ibargüengoytía
Integrative behavioral studies show that the interplay between individual physiology and social behavior influences the ecology of the species, ultimately affecting individual fitness. Particularly in lizards, color polymorphism is associated with differential behaviors and reproductive strategies, which are evident in mature males during the mating season. Dominant males generally have greater endurance, higher body temperature, and larger bodies than submissive males, so they can acquire and defend larger territories and have greater access to females for mating...
November 30, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29111465/effectiveness-of-circuit-based-exercises-on-gait-speed-balance-and-functional-mobility-in-people-affected-by-stroke-a-meta-analysis
#8
REVIEW
Ana Clara Bonini-Rocha, Anderson Lúcio Souza de Andrade, André Marques Moraes, Liana Barbaresco Gomide Matheus, Leonardo Rios Diniz, Wagner Rodrigues Martins
BACKGROUND: Several interventions are proposed to rehabilitate patients with neurological dysfunctions due to stroke. The effectiveness of Circuit-Based Exercises according to its actual definition, i.e., an overall program to improve strength, stamina, balance or functioning, was not provided. OBJECTIVE: To examine the effectiveness of circuit-based exercise in the treatment of people affected by stroke. METHOD: A search through PUBMED, EMBASE, Cochrane Library and PEDro databases was performed to identify controlled clinical trials without language or date restriction...
October 27, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28960110/the-process-of-becoming-a-user-of-an-osseointegrated-prosthesis-following-transfemoral-amputation-a-qualitative-study
#9
Cathrine Hjorth Hansen, Rehne Lessman Hansen, Peter Holmberg Jørgensen, Klaus Kjaer Petersen, Annelise Norlyk
PURPOSE: To investigate what characterizes the process of becoming a user of an osseointegrated prosthesis following transfemoral amputation. METHOD: The study is based on the descriptive phenomenological framework Reflective Lifeworld Research. Data were collected through in-depth interviews with seven participants who had undergone transfemoral implant surgery and currently used their osseointegrated prosthesis. Data were analyzed according to the guidelines given in Reflective Lifeworld Research...
September 29, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28955711/environmental-and-physiological-factors-associated-with-stamina-in-dogs-exercising-in-high-ambient-temperatures
#10
Patrick J Robbins, Meghan T Ramos, Brian M Zanghi, Cynthia M Otto
This IACUC approved study was performed to evaluate the environmental, physiological, and hematological components that contribute to stamina following successive bouts of exercise that included searching (5-min), agility (5-min), and ball retrieve (<10-min). Regularly exercised dogs (N = 12) were evaluated on five separate occasions. The population consisted of eight males and four females ranging in age from 8 to 23 months, which included six Labrador retrievers, three German shepherds, and one each English springer spaniel, German wirehaired pointer, and Dutch shepherd...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28947979/effects-of-intensity-modulated-radiotherapy-and-chemoradiotherapy-on-attention-in-patients-with-nasopharyngeal-cancer
#11
Qing Wei, Ling Li, Xiao-Dong Zhu, Ling Qin, Yan-Lin Mo, Zheng-You Liang, Jia-Li Deng, Su-Ping Tao
This study evaluated the short-term effects of intensity-modulated radiotherapy (IMRT) and cisplatin concurrent chemo-radiotherapy (CCRT) on attention in patients with nasopharyngeal cancer (NPC). Timely detection and early prevention of cognitive decline are important in cancer patients, because long-term cognitive effects may be permanent and irreversible. Thirty-eight NPC patients treated with IMRT (17/38) or CCRT (21/38) and 38 healthy controls were recruited for the study. Neuropsychological tests were administered to each patient before treatment initiation and within a week after treatment completion...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28867858/evaluation-of-cyavanapr%C3%A4-%C3%A5-a-on-health-and-immunity-related-parameters-in-healthy-children-a-two-arm-randomized-open-labeled-prospective-multicenter-clinical-study
#12
Arun Gupta, Sunil Kumar, Sanjeeva Dole, Shailesh Deshpande, Vaishali Deshpande, Sudha Singh, V Sasibhushan
CONTEXT: Cyavanaprāśa (CP) is an Ayurvedic immune booster formulation that confers vigor and vitality while delaying the ageing process. Benefits of CP have been studied widely in adult population. OBJECTIVES: Current study assessed beneficial effects of CP on health and immunity related parameters in healthy children. METHODS: This study was a 6 month long two armed, randomized, open labeled, prospective clinical study. School going healthy children between ages of 5-12 years were randomized to receive orally daily either CP (approx...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28859419/complex-reproductive-traits-and-whole-organism-performance
#13
T J Orr, Theodore Garland
Arnold's 1983 path-analytic paradigm, considering "morphology, performance, and fitness," has been elaborated in several ways. For example, current versions recognize the level of "behavior" (including aspects of motivation) as a filter between performance abilities (only measurable if motivation is maximal) and fitness components. Performance abilities constrain behavior, but behavioral choices may shield performance from selection. Conceptual and empirical issues remain, such as the extent to which individual variation in lower-level subordinate traits (e...
August 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28859403/plasmodium-infections-in-natural-populations-of-anolis-sagrei-reflect-tolerance-rather-than-susceptibility
#14
Camille Bonneaud, Irem Sepil, Lena Wilfert, Ryan Calsbeek
Parasites can represent formidable selection pressures for hosts, but the cost of infection is sometimes difficult to demonstrate in natural populations. While parasite exploitation strategies may, in some instances, actually inflict low costs on their hosts, the response of hosts to infection is also likely to determine whether or not these costs can be detected. Indeed, costs of infection may be obscured if infected individuals in the wild are those that are the most tolerant, rather than the most susceptible, to infection...
August 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28846503/does-self-control-training-improve-self-control-a-meta-analysis
#15
Malte Friese, Julius Frankenbach, Veronika Job, David D Loschelder
Self-control is positively associated with a host of beneficial outcomes. Therefore, psychological interventions that reliably improve self-control are of great societal value. A prominent idea suggests that training self-control by repeatedly overriding dominant responses should lead to broad improvements in self-control over time. Here, we conducted a random-effects meta-analysis based on robust variance estimation of the published and unpublished literature on self-control training effects. Results based on 33 studies and 158 effect sizes revealed a small-to-medium effect of g = 0...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28674681/myalgic-encephalomyelitis-chronic-fatigue-syndrome-diagnosis-and-management-in-young-people-a-primer
#16
REVIEW
Peter C Rowe, Rosemary A Underhill, Kenneth J Friedman, Alan Gurwitt, Marvin S Medow, Malcolm S Schwartz, Nigel Speight, Julian M Stewart, Rosamund Vallings, Katherine S Rowe
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease that affects children and adolescents as well as adults. The etiology has not been established. While many pediatricians and other health-care providers are aware of ME/CFS, they often lack essential knowledge that is necessary for diagnosis and treatment. Many young patients experience symptoms for years before receiving a diagnosis. This primer, written by the International Writing Group for Pediatric ME/CFS, provides information necessary to understand, diagnose, and manage the symptoms of ME/CFS in children and adolescents...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28642213/development-of-a-web-based-intervention-for-addressing-distress-in-caregivers-of-patients-receiving-stem-cell-transplants-formative-evaluation-with-qualitative-interviews-and-focus-groups
#17
Nicole Amoyal Pensak, Tanisha Joshi, Teresa Simoneau, Kristin Kilbourn, Alaina Carr, Jean Kutner, Mark L Laudenslager
BACKGROUND: Caregivers of cancer patients experience significant burden and distress including depression and anxiety. We previously demonstrated the efficacy of an eight session, in-person, one-on-one stress management intervention to reduce distress in caregivers of patients receiving allogeneic hematopoietic stem cell transplants (allo-HSCT). OBJECTIVE: The objective of this study was to adapt and enhance the in-person caregiver stress management intervention to a mobilized website (eg, tablet, smartphone, or computer-based) for self-delivery in order to enhance dissemination to caregiver populations most in need...
June 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28641585/cancer-bereaved-siblings-positive-and-negative-memories-and-experiences-of-illness-and-death-a-nationwide-follow-up
#18
Mary-Elizabeth Bradley Eilertsen, Malin Lövgren, Alexandra Eilegård Wallin, Ulrika Kreicbergs
OBJECTIVE: Our aim was to explore bereaved siblings' positive and negative memories and experiences of their brother's or sister's illness and death. METHOD: In our nationwide Swedish study, 174 of 240 (73%) bereaved siblings participated, and 70% responded to two open-ended statements, which focused on siblings' positive and negative memories and experiences of illness and death. The data were analyzed using systematic text condensation. RESULTS: The bereaved siblings' responses were categorized into four different themes: (1) endurance versus vulnerability, (2) family cohesion versus family conflicts, (3) growth versus stagnation, and (4) professional support versus lack of professional support...
June 23, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28592995/the-quest-for-epigenetic-regulation-underlying-unisexual-flower-development-in-cucumis-melo
#19
David Latrasse, Natalia Y Rodriguez-Granados, Alaguraj Veluchamy, Kiruthiga Gayathri Mariappan, Claudia Bevilacqua, Nicolas Crapart, Celine Camps, Vivien Sommard, Cécile Raynaud, Catherine Dogimont, Adnane Boualem, Moussa Benhamed, Abdelhafid Bendahmane
BACKGROUND: Melon (Cucumis melo) is an important vegetable crop from the Cucurbitaceae family and a reference model specie for sex determination, fruit ripening and vascular fluxes studies. Nevertheless, the nature and role of its epigenome in gene expression regulation and more specifically in sex determination remains largely unknown. RESULTS: We have investigated genome wide H3K27me3 and H3K9ac histone modifications and gene expression dynamics, in five melon organs...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28544443/development-of-a-clinical-trials-version-of-the-impact-of-weight-on-quality-of-life-lite-questionnaire-iwqol-lite-clinical-trials-version-results-from-two-qualitative-studies
#20
R L Kolotkin, C M Ervin, H H Meincke, L Højbjerre, S E Fehnel
Existing measures of health-related quality of life and patient functioning in obesity, such as the Impact of Weight on Quality of Life-Lite (IWQOL-Lite) questionnaire, lack the developmental rigour required by the Food and Drug Administration (FDA) to support product labelling. Two iterative qualitative studies informed development of a version of the IWQOL-Lite questionnaire optimized for use in obesity clinical trials: the IWQOL-Lite Clinical Trials Version. Study 1 included 42 patients with body mass index (BMI) ≥ 30 kg m(-2) (obesity); and Study 2 included 29 patients with type 2 diabetes and BMI ≥ 27 kg m(-2) (overweight)...
October 2017: Clinical Obesity
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