keyword
MENU ▼
Read by QxMD icon Read
search

Mgp

keyword
https://www.readbyqxmd.com/read/27886638/preliminary-evidence-that-negative-symptom-severity-relates-to-multilocus-genetic-profile-for-dopamine-signaling-capacity-and-d2-receptor-binding-in-healthy-controls-and-in-schizophrenia
#1
Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barch
Deficits in central, subcortical dopamine (DA) signaling may underlie negative symptom severity, particularly anhedonia, in healthy individuals and in schizophrenia. To investigate these relationships, we assessed negative symptoms with the Schedule for the Assessment of Negative Symptoms and the Brief Negative Symptom Scale (BNSS) and self-reported anhedonia with the Scales for Physical and Social Anhedonia (SPSA), Temporal Experience of Pleasure Scale, and Snaith-Hamilton Pleasure Scale in 36 healthy controls (HC), 27 siblings (SIB) of individuals with schizophrenia, and 66 individuals with schizophrenia or schizoaffective disorder (SCZ)...
November 17, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27861603/functional-response-fr-and-relative-growth-rate-rgr-do-not-show-the-known-invasiveness-of-lemna-minuta-kunth
#2
Wout Van Echelpoel, Pieter Boets, Peter L M Goethals
Growing travel and trade threatens biodiversity as it increases the rate of biological invasions globally, either by accidental or intentional introduction. Therefore, avoiding these impacts by forecasting invasions and impeding further spread is of utmost importance. In this study, three forecasting approaches were tested and combined to predict the invasive behaviour of the alien macrophyte Lemna minuta in comparison with the native Lemna minor: the functional response (FR) and relative growth rate (RGR), supplemented with a combined biomass-based nutrient removal (BBNR)...
2016: PloS One
https://www.readbyqxmd.com/read/27823565/an-improved-comparative-docking-approach-for-developing-specific-glycogen-phosphorylase-inhibitors-using-pentacyclic-triterpenes
#3
V Badireenath Konkimalla
Mitigation of unwanted effects is a major issue to be addressed in drug discovery. The human genome shares a considerable degree of sequence identity and structural homology whereby multiple binding pockets of similar composition is seen across different family of proteins. This distribution of similar binding pockets in different proteins is a major reason for cross reactivity upon ligand binding. Therefore, identifying such off-targets on a case-to-case basis in the early stages of drug discovery pipeline is very much essential...
November 4, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27819733/research-article-molecular-cloning-and-expression-analysis-of-a-matrix-gla-protein-gene-in-the-spinyhead-croaker-collichthys-lucidus
#4
W Song, M D Zhao, K J Jiang, F Y Zhang, M Zhao, Y Y Meng, L B Ma
The matrix Gla (gamma-carboxyglutamic acid-rich) protein (MGP), a vitamin K-dependent and Gla-containing protein, is a calcification inhibitor that mainly functions in tissue calcification and mineralization. In this study, we obtained the complete cDNA sequence of MGP from the spinyhead croaker (Collichthys lucidus), which we named Cl-MGP. Cl-MGP was 923 bp long with a 384-bp open reading fragment that encoded 127 amino acids. The predicted MGP protein sequence contained a 19-residue hydrophobic signal peptide, suggesting that it possesses secretory characteristics...
November 3, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27782369/the-structure-of-brain-glycogen-phosphorylase-from-allosteric-regulation-mechanisms-to-clinical-perspectives
#5
REVIEW
Cécile Mathieu, Jean-Marie Dupret, Fernando Rodrigues Lima
Glycogen phosphorylase (GP) is the key enzyme that regulates glycogen mobilization in cells. GP is a complex allosteric enzyme that comprises a family of three isozymes: muscle GP (mGP), liver GP (lGP), and brain GP (bGP). Although the three isozymes display high similarity and catalyze the same reaction, they differ in their sensitivity to the allosteric activator adenosine monophosphate (AMP). Moreover, inactivating mutations in mGP and lGP have been known to be associated with glycogen storage diseases (McArdle and Hers disease, respectively)...
October 26, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27777791/intravitreal-conbercept-injection-with-and-without-grid-laser-photocoagulation-in-the-treatment-of-diffuse-diabetic-macular-edema-in-real-life-clinical-practice
#6
Yule Xu, Ao Rong, Yanlong Bi, Wei Xu
Purpose. To evaluate the efficacy of intravitreal conbercept (IVC) plus modified grid laser photocoagulation (MGP) versus IVC alone for treatment of diffuse diabetic macular edema (DDME). Methods. In this retrospective study, 51 DDME patients were treated with either IVC alone (IVC group) or IVC plus MGP (combined group) with 12 months of follow-up. The clinical records of those patients were reviewed. Results. 26 patients (31 eyes) received IVC alone and 25 patients (30 eyes) received combined therapy. At month 12, the mean best-corrected visual acuity (BCVA) letter score improvement was 9...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27774543/cooperative-supramolecular-helical-assembly-of-a-pyridinium-tailored-methyl-glycyrrhetate
#7
Yuxia Gao, Jie Hao, Jindan Wu, Ying Li, Yuan Lin, Jun Hu, Yong Ju
Taking a natural triterpenoid as the building block, we have regulated a pyridinium-functionalized methyl glycyrrhetate (C4-MGP) into P-type helices in water primarily driven by hydrophobic forces. By analysing their temperature-dependent CD and UV-Vis spectra, these hierarchical chiral assemblies were found to be formed in a cooperative supramolecular polymerization manner.
October 24, 2016: Soft Matter
https://www.readbyqxmd.com/read/27764795/a-novel-3d-mesenchymal-stem-cell-model-of-the-multiple-myeloma-bone-marrow-niche-biologic-and-clinical-applications
#8
Jana Jakubikova, Danka Cholujova, Teru Hideshima, Paulina Gronesova, Andrea Soltysova, Takeshi Harada, Jungnam Joo, Sun-Young Kong, Raphael E Szalat, Paul G Richardson, Nikhil C Munshi, David M Dorfman, Kenneth C Anderson
Specific niches within the tumor bone marrow (BM) microenvironment afford a sanctuary for multiple myeloma (MM) clones due to stromal cell-tumor cell interactions, which confer survival advantage and drug resistance. Defining the sequelae of tumor cell interactions within the MM niches on an individualized basis may provide the rationale for personalized therapies. To mimic the MM niche, we here describe a new 3D co-culture ex-vivo model in which primary MM patient BM cells are co-cultured with mesenchymal stem cells (MSC) in a hydrogel 3D system...
October 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27752480/vitamin-k-dependent-protection-of-the-renal-microvasculature-histopathological-studies-in-normal-and-diseased-kidneys
#9
Fang-Fei Wei, Nadja E A Drummen, Lutgarde Thijs, Lotte Jacobs, Marjolein Herfs, Cynthia Van't Hoofd, Cees Vermeer, Jan A Staessen
Vitamin-K-dependent carboxylation of matrix Gla protein (MGP) protects the macrocirculation against calcification. We recently reported in a multiethnic population study that the estimated glomerular filtration rate, a microvascular trait, decreased and the risk of chronic kidney disease increased with higher circulating levels of inactive dephospho-uncarboxylated MGP, a marker of vitamin K deficiency. These findings highlighted the possibility that vitamin K might have a beneficial effect on the renal microcirculation...
September 2016: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/27751997/vkorc1-gene-vitamin-k-epoxide-reductase-polymorphisms-are-associated-with-cardiovascular-disease-in-chronic-kidney-disease-patients-on-hemodialysis
#10
Noha A Osman, Nevine El-Abd, Mohamed Nasrallah
Vitamin K is necessary for the carboxylation of clotting factors and matrix Gla protein (MGP). Vitamin K epoxide reductase (VKOR) is the enzyme responsible for recirculation of Vitamin K increasing its tissue availability. Polymorphisms of VKOR may alter the function of MGP, thereby influencing vascular calcification. We conducted this study to investigate the relationship of VKORC1 gene single nucleotide polymorphisms (SNP's) to vascular calcification and clinically overt cardiovascular disease in chronic kidney disease (CKD) patients on hemodialysis (HD)...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27713166/mfap5-and-tnnc1-potential-markers-for-predicting-occult-cervical-lymphatic-metastasis-and-prognosis-in-early-stage-tongue-cancer
#11
Xi Yang, Kailiu Wu, Siyi Li, Longwei Hu, Jing Han, Dongwang Zhu, Xuerui Tian, Wei Liu, Zhen Tian, Laiping Zhong, Ming Yan, Chenping Zhang, Zhiyuan Zhang
The purpose of this study is to identify candidate genes that could predict prognosis of early-stage tongue squamous cell carcinoma (TSCC) and its occult cervical lymphatic metastasis by large-scale gene expression profiling. Tumor tissue and matched normal mucosa samples were collected from patients with TSCC and analyzed with Affymetrix HTA2.0 high-density oligonucleotide array. Differentially expressed genes in TSCC with cervical lymph node metastasis (CLNM) were further analyzed with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes for their functions and related pathways...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27667722/prevalence-of-human-papillomavirus-types-viral-load-and-physical-status-of-hpv16-in-head-and-neck-squamous-cell-carcinoma-from-the-south-swedish-health-care-region
#12
Helena Faust, Erika Eldenhed Alwan, Alexander Roslin, Johan Wennerberg, Ola Forslund
Incidence of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is rising in several countries. Intriguingly, large variations of HPV16 viral load and different proportions of the physical viral status among HNSCC have been reported. We analysed fresh biopsies of 275 HNSCC patients from the South Swedish Health Care Region for HPV types with modified general primer PCR and Luminex. Seventy-eight HPV16-positive HNSCC cases were further investigated for viral DNA load and physical status using quantitative PCR for HPV E2 and E7 genes...
November 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27646113/overexpression-of-histone-demethylase-fbxl10-leads-to-enhanced-migration-in-mouse-embryonic-fibroblasts
#13
Magdalena Rohde, Elisabeth Sievers, Andreas Janzer, Dominica Willmann, Angela Egert, Hubert Schorle, Roland Schüle, Jutta Kirfel
Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing, immune responses and invasive tumors all require the orchestrated movement of cells to specific locations. Histone demethylase proteins alter transcription by regulating the chromatin state at specific gene loci. FBXL10 is a conserved and ubiquitously expressed member of the JmjC domain-containing histone demethylase family and is implicated in the demethylation of H3K4me3 and H3K36me2 and thereby removing active chromatin marks...
September 16, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27621560/pcr-and-genotyping-for-hpv-in-cervical-cancer-patients
#14
Pradyot Prakash, Shashikant C U Patne, Ashish Kumar Singh, Mohan Kumar, Mukti Nath Mishra, Anil Kumar Gulati
AIMS: To devise nested multiplex polymerase chain reaction (NMPCR) protocol for detection of mucosal human papilloma viruses (HPVs) and typing of HPV-16 and -18 in formalin-fixed, paraffin-embedded (FFPE) tissues of carcinoma cervix (CaCx). SETTINGS AND DESIGN: Cross-sectional observational study. MATERIALS AND METHODS: NMPCR was done for simultaneous detection of HPV, targeting 134 bp L1 capsid gene employing GP+/mGP+ primers and typing of genotypes-16 and -18, targeting E6/E7 gene from 34 FFPE tissue blocks of CaCx and cervical intraepithelial neoplasia (CIN)...
July 2016: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/27613626/long-trend-reduction-of-phosphorus-wastewater-loading-in-the-seine-determination-of-phosphorus-speciation-and-sorption-for-modeling-algal-growth
#15
Najla Aissa-Grouz, Josette Garnier, Gilles Billen
The lower Seine River is severely affected by the release of the treated wastewater from the 12 million inhabitants of the Paris agglomeration. Whereas urban effluents were the major source of phosphorus pollution in the late 1980s, the ban on polyphosphates from detergents in 1991 considerably reduced the phosphorus (P) loading to the Seine River and was followed in 2000 by the implementation of phosphorus treatment in the largest wastewater treatment plant of Paris conurbation (Seine Aval). Phosphorus discharged to the rivers from domestic wastewater was reduced by 80 %, significantly decreasing phytoplankton biomass in the large branches of the Seine River...
September 9, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27597840/adipogenic-gene-expression-in-gilthead-sea-bream-mesenchymal-stem-cells-from-different-origin
#16
Cristina Salmerón, Natàlia Riera-Heredia, Joaquim Gutiérrez, Isabel Navarro, Encarnación Capilla
During the last decades, adipogenesis has become an emerging field of study in aquaculture due to the relevance of the adipose tissue in many physiological processes and its connection with the endocrine system. In this sense, recent studies have translated into the establishment of preadipocyte culture models from several fish species, sometimes lacking information on the mRNA levels of adipogenic genes. Thus, the aim of this study was to determine the gene expression profile of gilthead sea bream (Sparus aurata) primary cultured mesenchymal stem cells (MSCs) from different origin (adipose tissue and vertebra bone) during adipogenesis...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27593913/a-single-gene-connects-stiffness-in-glaucoma-and-the-vascular-system
#17
Teresa Borrás
Arterial calcification results in arterial stiffness and higher systolic blood pressure. Arterial calcification is prevented by the high expression of the Matrix-Gla gene (MGP) in the vascular smooth muscle cells (VSMC) of the arteries' tunica media. Originally, MGP, a gene highly expressed in cartilage and VSMC, was found to be one of the top expressed genes in the trabecular meshwork. The creation of an Mgp-lacZ Knock-In mouse and the use of mouse genetics revealed that in the eye, Mgp's abundant expression is localized and restricted to glaucoma-associated tissues from the anterior and posterior segments...
September 1, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27575029/comparing-the-use-of-sewage-sludge-ash-and-glass-powder-in-cement-mortars
#18
Zhen Chen, Chi Sun Poon
This study explored the suitability of using sewage sludge ash (SSA) and mixed-coloured glass powder (MGP) as construction materials in cement mortars. Positive findings from this study may help promote the recycling of waste SSA and MGP in construction works. The results indicated that the SSA decreased while MGP improved the mortar workability. The SSA exhibited very low pozzolanic activity, but the cement mortar prepared with 20% SSA yielded strength values slightly superior to those of the glass mortars due to its water absorption ability...
August 30, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27563203/histochemical-detection-and-comparison-of-apoptotic-cells-in-the-gingival-epithelium-using-hematoxylin-and-eosin-and-methyl-green-pyronin-a-pilot-study
#19
Aarati Nayak, Anita Raikar, Vijaylaxmi Kotrashetti, Ramakant Nayak, Sumedha Shree, Soumya Kambali
BACKGROUND: Apoptosis plays a critical role in the regulation of inflammation and host immune response. It helps in tissue homeostasis and a disturbance in this is often associated with disease. The use of histochemical stains like hematoxylin and eosin (H and E) and methyl green-pyronin (MGP) can provide a simple and cost-effective method for the detection of apoptotic cells. AIM: Study intended to analyze the expression of apoptosis in the gingival epithelium of healthy subjects and in patients with chronic periodontitis, using H and E and MGP...
May 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/27556859/a-novel-molecular-and-clinical-staging-model-to-predict-survival-for-patients-with-esophageal-squamous-cell-carcinoma
#20
Wei Wang, Zhiwei Wang, Jun Zhao, Min Wei, Xinghua Zhu, Qi He, Tianlong Ling, Xiaoyan Chen, Ziang Cao, Yixin Zhang, Lei Liu, Minxin Shi
Current prognostic factors fail to accurately determine prognosis for patients with esophageal squamous cell carcinoma (ESCC) after surgery. Here, we constructed a survival prediction model for prognostication in patients with ESCC. Candidate molecular biomarkers were extracted from the Gene Expression Omnibus (GEO), and Cox regression analysis was performed to determine significant prognostic factors. The survival prediction model was constructed based on cluster and discriminant analyses in a training cohort (N=205), and validated in a test cohort (N=207)...
August 18, 2016: Oncotarget
keyword
keyword
17722
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"