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https://www.readbyqxmd.com/read/29584693/is-matrix-gla-protein-associated-with-vascular-calcification-a-systematic-review
#1
REVIEW
Hilary Barrett, Mary O'Keeffe, Eamon Kavanagh, Michael Walsh, Eibhlís M O'Connor
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla protein (MGP), a tissue-derived vitamin K dependent protein, is reported to be an important inhibitor of vascular calcification and may have clinical potential to modify the progression of vascular calcification through regulation of functional MGP fractions. This systematic review examines twenty-eight studies which assess the relationship between circulating protein expressions of MGP species and vascular calcification in different arterial beds...
March 27, 2018: Nutrients
https://www.readbyqxmd.com/read/29582552/efficacy-and-tolerability-of-magnesium-plus-protein-for-managing-hypomagnesemia-in-pediatric-kidney-transplant-patients
#2
Teresa V Lewis, Stephen Neely, Martin A Turman
We sought to investigate whether magnesium oxide bound to soy protein (MGP) increases serum magnesium concentrations with less diarrhea compared to commonly prescribed magnesium salts. Subjects were switched to MGP at a near-equivalent daily elemental magnesium dose. Mean serum magnesium levels were compared. If magnesium levels remained <1.7 mg/dL after switching to MGP, subjects were enrolled into Part 2 and received a one-time MGP dose adjustment. The MGP daily dose was increased by 266 mg. For both parts 1 and 2, subjects recorded the number and quality of their stools to assess gastrointestinal (GI) tolerability of MGP...
March 27, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29563538/ucma-grp-inhibits-phosphate-induced-vascular-smooth-muscle-cell-calcification-via-smad-dependent-bmp-signalling
#3
Brecht A Willems, Malgorzata Furmanik, Marjolein M J Caron, Martijn L L Chatrou, Dennis H M Kusters, Tim J M Welting, Michael Stock, Marta S Rafael, Carla S B Viegas, Dina C Simes, Cees Vermeer, Chris P M Reutelingsperger, Leon J Schurgers
Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in part, to be induced by phosphate imbalance. The molecular mechanisms that regulate VC are not fully known. Here we propose a novel role for the mineralisation regulator Ucma/GRP (Upper zone of growth plate and Cartilage Matrix Associated protein/Gla Rich Protein) in phosphate-induced VSMC calcification...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29561783/bicuspid-aortic-valve-stenosis-and-the-effect-of-vitamin-k2-on-calcification-using-18-f-sodium-fluoride-positron-emission-tomography-magnetic-resonance-the-basik2-rationale-and-trial-design
#4
Frederique E C M Peeters, Manouk J W van Mourik, Steven J R Meex, Jan Bucerius, Simon M Schalla, Suzanne C Gerretsen, Casper Mihl, Marc R Dweck, Leon J Schurgers, Joachim E Wildberger, Harry J G M Crijns, Bas L J H Kietselaer
BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) on imaging measurements of calcification in the bicuspid aortic valve (BAV) and calcific aortic valve stenosis (CAVS). BAV is associated with early development of CAVS. Pathophysiologic mechanisms are incompletely defined, and the only treatment available is valve replacement upon progression to severe symptomatic stenosis. Matrix Gla protein (MGP) inactivity is suggested to be involved in progression...
March 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29552534/status-of-single-nucleotide-polymorphism-of-matrix-gla-protein-gene-rs4236-in-nephrolithiasis-a-preliminary-study-in-indian-population
#5
Anandan Murugesan, Lakshman Kumar, P Janarthanan
Background: Urine is a supersaturated solution with solutes in very high concentration. Matrix gla protein (MGP) is one of the proteins involved in inhibition of extracellular calcification. Among the various polymorphisms studied, polymorphism of SNP rs4236 in the MGP gene is found to have association with nephrolithiasis. We evaluated the significance of SNP rs4236 polymorphism in nephrolithiasis among the Indian population. Materials and Methods: The study was conducted in 2013 and 2014 among fifty participants...
January 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29529056/epidemiological-and-histological-findings-implicate-matrix-gla-protein-in-diastolic-left-ventricular-dysfunction
#6
Fang-Fei Wei, Sander Trenson, Pierre Monney, Wen-Yi Yang, Menno Pruijm, Zhen-Yu Zhang, Yassine Bouatou, Qi-Fang Huang, Belen Ponte, Pierre-Yves Martin, Lutgarde Thijs, Tatiana Kuznetsova, Karel Allegaert, Stefan Janssens, Cees Vermeer, Peter Verhamme, Michel Burnier, Murielle Bochud, Georg Ehret, Jan A Staessen
OBJECTIVES: A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure-a measure of diastolic LV dysfunction-increases with higher plasma level of inactive desphospho-uncarboxylated MGP (dp-ucMGP). We also studied the distribution of active and inactive MGP in human myocardium. METHODS: We measured echocardiographic diastolic LV function and plasma dp-ucMGP (ELISA) in 668 Flemish and for replication in 386 Swiss...
2018: PloS One
https://www.readbyqxmd.com/read/29488969/combined-yeast-and-microalgal-cultivation-in-a-pilot-scale-raceway-pond-for-urban-wastewater-treatment-and-potential-biodiesel-production
#7
F Iasimone, G Zuccaro, V D'Oriano, G Franci, M Galdiero, D Pirozzi, V De Felice, F Pirozzi
A mixed culture of oleaginous yeast Lipomyces starkeyi and wastewater native microalgae (mostly Scenedesmus sp. and Chlorella sp.) was performed to enhance lipid and biomass production from urban wastewaters. A 400 L raceway pond, operating outdoors, was designed and used for biomass cultivation. Microalgae and yeast were inoculated into the cultivation pond with a 2:1 inoculum ratio. Their concentrations were monitored for 14 continuous days of batch cultivation. Microalgal growth presented a 3-day initial lag-phase, while yeast growth occurred in the first few days...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29483527/the-influence-of-a-high-fat-diet-on-bone-and-soft-tissue-formation-in-matrix-gla-protein-knockout-mice
#8
S A Lanham, F R Cagampang, R O C Oreffo
Studies suggest bone growth and development are influenced by maternal nutrition, during intrauterine and early postnatal life. This study assessed the role of MGP and a maternal high fat diet on vitamin K-dependent proteins' gene expression and their impact on bone formation. Knockout (KO) offspring were smaller than wild type (WT) littermates, yet possessed the same volume of intrascapular brown adipose tissue. The total proportion of body fat was reduced, but only in animals on a control diet. Lung air volume was observed to be comparable in both KO and WT animals on the same diet...
February 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29480643/role-of-matrix-gla-protein-in-midface-development-recent-advances
#9
J Marulanda, M Murshed
Craniofacial development is a delicate process that involves complex interactions among cells of multiple developmental origins, their migration, proliferation, and differentiation. Tissue morphogenesis of the craniofacial skeleton depends on genetic and environmental factors, and on specific signaling pathways, which are still not well understood. Developmental defects of the midface caused by the absence, delays, or premature fusion of nasal and maxillary prominences vary in severity; leading to clefts, hypoplasias, and midline expansion...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29471095/proteomic-of-goat-milk-whey-and-its-bacteriostatic-and-antitumour-potential
#10
Gracy K V V Medeiros, Rita C R E Queiroga, Whyara K A Costa, Carlos A A Gadelha, Rodrigo R E Lacerda, José T J G Lacerda, Luciano S Pinto, Elizandra Braganhol, Fernanda C Teixeira, Paula P de S Barbosa, Maria I F Campos, Gregório F Gonçalves, Hilzeth L F Pessôa, Tatiane S Gadelha
Goat whey is normally discarded in the milk processing industry. However, several studies have addressed its biological properties and possible use in human or animal diet. The present study aimed to analysis the protein profile of goat whey to evaluate its possible oxidant, antioxidant, antibacterial, antitumour, and cytotoxic activities in vitro against human erythrocytes. Goat whey was skimmed, and crude protein extract (CPE) was obtained. Next, protein fractions (F) were obtained using ammonium sulphate precipitation method...
February 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29453066/synthesis-of-a-stable-magnesium-impregnated-biochar-and-its-reduction-of-phosphorus-leaching-from-soil
#11
Qincheng Chen, Jiaolong Qin, Zhiwen Cheng, Lu Huang, Peng Sun, Lu Chen, Guoqing Shen
Biochar improves soil fertility and promotes long-term terrestrial carbon sequestration. However, biochar seems not to be stable enough due to physical, chemical and biological reactions. In this study, a novel, stable, and magnesium (Mg)-impregnated biochar was prepared from cow dung and applied to decrease P leaching from soil. XPS, FTIR, XRD, SEM and EDS were used to evaluate the effect of modification and phosphorus(P) sorption on the oxidation resistance of biochar. The results showed that the oxidation resistance of the Mg-impregnated biochar was improved by the formation of MgO on its surface...
February 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29434243/isolation-and-expansion-of-multipotent-progenitors-from-human-trabecular-meshwork
#12
Yuan Zhang, Subo Cai, Scheffer C G Tseng, Ying-Ting Zhu
To expand multi-potent progenitors from human trabecular meshwork (TM), we have created a new optimized method on two-dimensional (2D) followed by three-dimensional (3D) Matrigel in modified embryonic stem cell medium supplemented with 5% fetal bovine serum (MESCM + 5% FBS). The expanded TM cells were small cuboidal cells expressing TM markers such as AQP1, MGP, CHI3L1, and AnkG, embryonic stem cell (ESC) markers such as Oct4, Sox2, Nanog, and ABCG2, and neural crest (NC) markers such as p75NTR, FOXD3, Sox9, Sox10, and MSX1...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29402827/expanded-haemodialysis-therapy-of-chronic-haemodialysis-patients-prevents-calcification-and-apoptosis-of-vascular-smooth-muscle-cells-in-vitro
#13
Kevin Willy, Matthias Girndt, Jakob Voelkl, Roman Fiedler, Peter Martus, Markus Storr, Ralf Schindler, Daniel Zickler
BACKGROUND: Vascular calcification is a common phenomenon in patients with chronic kidney disease and strongly associated with increased cardiovascular mortality. Vascular calcification is an active process mediated in part by inflammatory processes in vascular smooth muscle cells (VSMC). These could be modified by the insufficient removal of proinflammatory cytokines through conventional high-flux (HF) membranes. Recent trials demonstrated a reduction of inflammation in VSMC by use of dialysis membranes with a higher and steeper cut-off...
December 22, 2017: Blood Purification
https://www.readbyqxmd.com/read/29396825/performance-of-a2no-mbr-process-in-treating-synthetic-and-municipal-wastewater
#14
Chuanyi Zhang, Guangrong Sun, Kuixia Zhao, Siqi Zou, Limei Yuan
In this study, a novel anaerobic-anoxic/nitrification (A2N) two-sludge sequencing batch reactor (SBR) configured with post-aeration (A2NO-membrane bioreactor process) was conducted to evaluate the operational efficiency, process characteristics, and microbial community structure in treating synthetic and municipal wastewater. When influent C/N ratios were 4.2-8.6, the removal efficiencies of COD, NH4+-N, TN, and TP were 86.4-90.0, 85.2-93.6, 61.8-76.0, and 97.6-99.3%, respectively, and the effluent concentrations met the first level A criteria of GB18918-2002...
February 2, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29392320/a-naturally-fluorescent-mgp-transgenic-mouse-for-angiogenesis-and-glaucoma-longitudinal-studies
#15
Priyadarsini Asokan, Rajendra N Mitra, Ramesh Periasamy, Zongchao Han, Teresa Borrás
Purpose: Our goal was to generate and characterize a new mouse model in which only angiogenesis- and glaucoma-relevant tissues would be naturally fluorescent. The Matrix Gla (MGP) gene is highly expressed in vascular smooth muscle cells (VSMC) and trabecular meshwork (TM). We sought to direct our Mgp-Cre.KI mouse recombinase to VSMC/TM cells to produce their longitudinal fluorescent profiles. Methods: Homozygous Mgp-Cre.KI mice were crossed with Ai9 homozygous reporter mice harboring a loxP-flanked STOP cassette preventing transcription of a DsRed fluorescent protein (tdTomato)...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29385041/microwave-hydrothermal-treated-grape-peel-as-an-efficient-biosorbent-for-methylene-blue-removal
#16
Lin Ma, Chunhai Jiang, Zhenyu Lin, Zhimin Zou
Biosorption using agricultural wastes has been proven as a low cost and efficient way for wastewater treatment. Herein, grape peel treated by microwave- and conventional-hydrothermal processes was used as low cost biosorbent to remove methylene blue (MB) from aqueous solutions. The adsorption parameters including the initial pH value, dosage of biosorbents, contact time, and initial MB concentration were investigated to find the optimum adsorption conditions. The biosorbent obtained by microwave-hydrothermal treatment only for 3 min at 180 °C (microwave-hydrothermal treated grape peel, MGP) showed faster kinetics and higher adsorption capability than that produced by a conventional-hydrothermal process (hydrothermal treated grape peel, HGP) with a duration time of 16 h...
January 31, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29349779/skeletogenesis-in-the-persian-sturgeon-acipenser-persicus-and-its-correlation-with-gene-expression-of-vitamin-k-dependent-proteins-during-larval-development
#17
H Eshaghzadeh, A Akbarzadeh, M Yarmohammadi, E Gisbert
The present study describes morphological development of the skeleton in the Persian sturgeon Acipenser persicus and discusses the hypothesis that expression of genes encoding vitamin K-dependent proteins (VKDP) might be correlated with the mineralization of skeletal tissues during early development in sturgeons. Results showed that development of cartilage started just after hatching (mean ± S.D., 10·9 ± 0·7 mm in total length, LT ) in the head and notochord, whereas the first signs of mineralization occurred in the dentary and in the dermopalatine and palatopterygoid elements of the upper jaw, coinciding with the onset of exogenous feeding (20·1 ± 1·5 mm LT )...
February 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29303985/desphospho-uncarboxylated-matrix-gla-protein-is-increased-postoperatively-in-cardiovascular-risk-patients
#18
Sofia Dahlberg, Jacob Ede, Leon Schurgers, Cees Vermeer, Thomas Kander, Bengt Klarin, Ulf Schött
BACKGROUND: Matrix Gla protein (MGP) is an extrahepatic protein that is dependent on glutamate carboxylation, a vitamin K-dependent process. Its dysfunctional form, desphospho-uncarboxylated-MGP, has been associated with increased arterial calcification and stiffness. The aim of this study was to measure the degree of postoperative carboxylation of MGP and two other Gla proteins in patients scheduled for abdominal or orthopaedic surgery. METHODS: Forty patients undergoing abdominal or orthopaedic surgery were included...
January 5, 2018: Nutrients
https://www.readbyqxmd.com/read/29303380/should-vitamin-k-be-supplemented-instead-of-antagonised-in-patients-with-idiopathic-pulmonary-fibrosis
#19
Bart De Brouwer, Ianthe Piscaer, Jan H Von Der Thusen, Jan C Grutters, Roger Eg Schutgens, Emiel Fm Wouters, Rob Janssen
There is an ongoing need for additional interventions in idiopathic pulmonary fibrosis (IPF) as antifibrotic drugs currently available only inhibit and do not stall disease progression. Vitamin K is a co-factor for the activation of coagulation factors. However, it is also required to activate proteins with functions outside of the coagulation cascade, such as matrix Gla protein (MGP), a defender against soft tissue calcification. Vitamin K antagonists are anticoagulants that are, for unknown reasons, associated with increased mortality in IPF...
March 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29301790/chronic-kidney-disease-circulating-calciprotein-particles-and-extracellular-vesicles-promote-vascular-calcification-a-role-for-grp-gla-rich-protein
#20
Carla S B Viegas, Lúcia Santos, Anjos L Macedo, António A Matos, Ana P Silva, Pedro L Neves, An Staes, Kris Gevaert, Rute Morais, Cees Vermeer, Leon Schurgers, Dina C Simes
OBJECTIVE: Inhibition of mineral crystal formation is a crucial step in ectopic calcification. Serum calciprotein particles (CPPs) have been linked to chronic kidney disease (CKD) calcification propensity, but additional knowledge is required to understand their function, assemblage, and composition. The role of other circulating nanostructures, such as extracellular vesicles (EVs) in vascular calcification is currently unknown. Here, we investigated the association of GRP (Gla-rich protein) with circulating CPP and EVs and the role of CKD CPPs and EVs in vascular calcification...
March 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
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