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https://www.readbyqxmd.com/read/29033966/impaired-magnesium-protoporphyrin-ix-methyltransferase-chlm-impedes-chlorophyll-synthesis-and-plant-growth-in-rice
#1
Zhaohai Wang, Xiao Hong, Keke Hu, Ya Wang, Xiaoxin Wang, Shiyun Du, Yang Li, Dandan Hu, Kexin Cheng, Baoguang An, Yangsheng Li
Magnesium protoporphyrin IX methyltransferase (ChlM) catalyzes the formation of magnesium protoporphyrin IX monomethylester (MgPME) from magnesium protoporphyrin IX (MgP) in the chlorophyll synthesis pathway. However, no ChlM gene has yet been identified and studied in monocotyledonous plants. In this study, a spontaneous mutant, yellow-green leaf 18 (ygl18), was isolated from rice (Oryza sativa). This mutant showed yellow-green leaves, decreased chlorophyll level, and climate-dependent growth differences. Map-based cloning of this mutant identified the YGL18 gene LOC_Os06g04150...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28992263/desphospho-uncarboxylated-matrix-gla-protein-is-a-novel-circulating-biomarker-predicting-deterioration-of-renal-function-in-the-general-population
#2
Fang-Fei Wei, Sander Trenson, Lutgarde Thijs, Qi-Fang Huang, Zhen-Yu Zhang, Wen-Yi Yang, Paula Moliterno, Karel Allegaert, José Boggia, Stefan Janssens, Peter Verhamme, Cees Vermeer, Jan A Staessen
Background: Recent studies showing an inverse association between estimated glomerular filtration rate (eGFR), a microvascular trait, and inactive desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) support the hypothesis that after vitamin K-dependent activation, matrix Gla protein (MGP) is renoprotective, but these were limited by their cross-sectional design. Methods: In 1009 randomly recruited Flemish (50.6% women), we assessed the association between eGFR and plasma dp-ucMGP, using multivariable-adjusted analyses...
August 25, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28975977/mgp-is-downregulated-due-to-promoter-methylation-in-chemoresistant-er-breast-cancer-and-high-mgp-expression-predicts-better-survival-outcomes
#3
Y-L Tuo, Y-F Ye
OBJECTIVE: In this study, we aimed to investigate the underlying mechanisms of MGP downregulation in chemoresistant ER+ breast cancer cells and its association with survival outcomes in breast cancer patients. MATERIALS AND METHODS: Microarray data of dysregulated genes in chemoresistant ER+ breast cancer cells were searched in GEO datasets. MGP expression in breast cancer patients and its DNA methylation status were analyzed in TCGA database. MGP promoter methylation was assessed using Methylation-Specific PCR (MSP) assay...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28936738/vascular-calcification-regulation-by-exosomes-in-the-vascular-wall
#4
Marcel Liberman, Luciana Cavalheiro Marti
Vascular calcification is a tightly regulated process that increases during ageing and occurs mainly in patients with diabetes and chronic renal failure. Exosomes are small membrane vesicles that are synthesized in a particular population of endosomes, also called multivesicular bodies, by inside budding into the lumen of the compartment. After fusion of exosome with the plasma membrane, these internal vesicles are secreted. Exosomes have a defined set of membrane and cytosolic proteins. The physiological function of exosomes is still a matter of debate...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28899571/simultaneous-recovery-of-calcium-phosphate-granules-and-methane-in-anaerobic-treatment-of-black-water-effect-of-bicarbonate-and-calcium-fluctuations
#5
J R Cunha, T Tervahauta, R D van der Weijden, L Hernández Leal, G Zeeman, C J N Buisman
Calcium phosphate (CaP) granules were discovered in the anaerobic treatment of vacuum collected black water (BW), using upflow anaerobic sludge blanket (UASB) technology. This allows simultaneous recovery of CaP granules and methane in the UASB reactor. However, the role of BW composition on CaP granulation is not yet understood. Moreover, CaP granulation was not observed in previous research on anaerobic treatment of BW, although similar treatment conditions were applied. Therefore, this study shows specifically the influence of bicarbonate and calcium fluctuations in BW on the phosphorus accumulation in the UASB reactor, which directly affects CaP granulation...
September 9, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28876251/removal-of-phosphorus-using-suspended-reactive-filters-srfs-efficiency-and-potential-applications
#6
Agnieszka Karczmarczyk, Agnieszka Bus
The removal of phosphorus (P) from agricultural runoff is essential to reduce the threat of eutrophication in bodies of water. In this study, an alternative method of applying P reactive materials (RMs) in the form of suspended reactive filters (SRFs) is presented. The SRF method enables P which has already entered a body of water to be caught. In this study, an autoclaved aerated concrete (AAC) was used as the SRFs. The experiment was carried out in a laboratory in a hydraulic block of 1 m in width and 2 m in length...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28873756/phytosterols-induced-viscoelasticity-of-oleogels-prepared-by-using-monoglycerides
#7
Mohd Dona Bin Sintang, Sabine Danthine, Allison Brown, Davy Van de Walle, Ashok R Patel, Iris Tavernier, Tom Rimaux, Koen Dewettinck
Monoglycerides (MGs) and phytosterols (PS) are known to form firm oleogels with liquid oil. However, the oleogels are prone to undergo polymorphic transition over time that lead to crystals' aggregation thus, compromises physical properties. Thus, we combined MGs with PS to control the crystallization and modify the morphology of the combination oleogels, as both components are reported to interact together. The oleogels were prepared at different ratio combinations and characterized in their rheological, thermal, morphology, and diffraction properties...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28865376/assessment-of-the-microbial-growth-potential-of-slow-sand-filtrate-with-the-biomass-production-potential-test-in-comparison-with-the-assimilable-organic-carbon-method
#8
Dick van der Kooij, Harm R Veenendaal, Ed J van der Mark, Marco Dignum
Slow sand filtration is the final treatment step at four surface-water supplies in the Netherlands. The microbial growth potential (MGP) of the finished water was measured with the assimilable organic carbon (AOC) method using pure cultures and the biomass production potential (BPP) test. In the BPP test, water samples were incubated untreated at 25 °C and the active-biomass concentration was measured by adenosine tri-phosphate (ATP) analysis. Addition of a river-water inoculum improved the test performance and characteristic growth and maintenance profiles of the water were obtained...
November 15, 2017: Water Research
https://www.readbyqxmd.com/read/28855172/genome-wide-association-and-functional-studies-identify-a-role-for-matrix-gla-protein-in-osteoarthritis-of-the-hand
#9
Wouter den Hollander, Cindy G Boer, Deborah J Hart, Michelle S Yau, Yolande F M Ramos, Sarah Metrustry, Linda Broer, Joris Deelen, L Adrienne Cupples, Fernando Rivadeneira, Margreet Kloppenburg, Marjolein Peters, Tim D Spector, Albert Hofman, P Eline Slagboom, Rob G H H Nelissen, André G Uitterlinden, David T Felson, Ana M Valdes, Ingrid Meulenbelt, Joyce J B van Meurs
OBJECTIVE: Osteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; however, only few genetic risk loci for hand OA have been identified. Our aim was to identify novel genes associated with hand OA and examine the underlying mechanism. METHODS: We performed a genome-wide association study of a quantitative measure of hand OA in 12 784 individuals (discovery: 8743, replication: 4011)...
August 30, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28844316/identifying-early-pathogenic-events-during-vascular-calcification-in-uremic-rats
#10
Luis Hortells, Cecilia Sosa, Natalia Guillén, Susana Lucea, Ángel Millán, Víctor Sorribas
Vascular calcification in chronic kidney disease is a very complex process traditionally explained in multifactorial terms. Here we sought to clarify relevance of the diverse agents acting on vascular calcification in uremic rats and distinguish between initiating and complicating factors. After 5/6 nephrectomy, rats were fed a 1.2% phosphorus diet and analyzed at different time points. The earliest changes observed in the aortic wall were noticed 11 weeks after nephrectomy: increased Wnt inhibitor Dkk1 mRNA expression and tissue non-specific alkaline phosphatase (TNAP) expression and activity...
August 23, 2017: Kidney International
https://www.readbyqxmd.com/read/28838957/vascular-endothelium-plays-a-key-role-in-directing-pulmonary-epithelial-cell-differentiation
#11
Jiayi Yao, Pierre J Guihard, Xiuju Wu, Ana M Blazquez-Medela, Melissa J Spencer, Medet Jumabay, Peter Tontonoz, Alan M Fogelman, Kristina I Boström, Yucheng Yao
The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic differentiation in the pulmonary epithelium. We demonstrate uncontrolled induction of the hepatic growth factor (HGF) caused by dysregulated cross talk between pulmonary endothelium and epithelium in Mgp-null lungs. Elevated HGF induced hepatocyte nuclear factor 4 α (Hnf4a), which competed with NK2 homeobox 1 (Nkx2...
October 2, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28821877/association-of-matrix-gla-protein-gene-rs1800801-rs1800802-rs4236-polymorphism-with-vascular-calcification-and-atherosclerotic-disease-a-meta-analysis
#12
Kaixiang Sheng, Ping Zhang, Weiqiang Lin, Jun Cheng, Jiawei Li, Jianghua Chen
Association between the MGP gene rs1800801, rs1800802, rs4236 polymorphisms and vascular calcification and atherosclerotic disease was inconsistent. To clarify precise association, we performed this meta-analysis. Medline, Embase and China Knowledge Resource Integrated Database were systematically searched through December 2016. A total of 23 case-control studies, consisting of 5280 cases and 5773 controls, were included. The overall results suggested that the -7A polymorphism was associated with an increased risk for vascular calcification and atherosclerotic disease in the recessive model (OR = 1...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801746/laparoscopic-nissen-fundoplication-plus-mid-gastric-plication-for-treatment-of-obese-patients-with-gastroesophageal-reflux-disease
#13
Ahmed Talha, Mohammed Ibrahim
BACKGROUND: Gastroesophageal reflux disease (GERD) is commonly associated with obesity, and its surgical management is debatable. OBJECTIVE: The objective of this study was to prove the safety and feasibility of laparoscopic Nissen's fundoplication (LNF) combined with mid-gastric plication (MGP) for treatment of obese patients with GERD. METHODS: LNF combined with MGP was done for 18 patients. All interventions were performed under general anesthesia...
August 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28746447/the-first-assessment-of-the-stress-inducible-defense-of-leucaena-leucocephala-with-acaricidal-potential-effect-against-rhipicephalus-boophilus-microplus-acari-ixodidae
#14
Lêdia Feitosa Wanderley, Karla Lílian Rodrigues Batista, Jorgiane Furtado de Carvalho, Aldilene da Silva Lima, Gabriel Alves Landulfo, Alexandra Martins Dos Santos Soares, Livio Martins Costa
Plants respond to wounding caused by mechanical stress or herbivory by synthesizing defense proteins. There are no studies reporting the action of induced plant proteins against ticks. The aim of this study was to investigate the effect of mechanically wounded Leucaena leucocephala leaves against Rhipicephalus (Boophilus) microplus. Initially, we carried out time course experiments to evaluate the impact of mechanical wounding on the protein content and the peroxidase, catalase and protease inhibitor activities in L...
April 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28734846/matrix-gla-protein-t-138c-polymorphism-is-associated-with-carotid-intima-media-thickness-and-predicts-mortality-in-patients-with-diabetic-nephropathy
#15
Stefanos Roumeliotis, Athanasios Roumeliotis, Stylianos Panagoutsos, Efstathia Giannakopoulou, Nikolaos Papanas, Vangelis G Manolopoulos, Ploumis Passadakis, Anna Tavridou
AIMS: We sought to determine the predictive value of Matrix Gla Protein MGP T-138C polymorphism in relation to all-cause mortality, cardiovascular mortality and cardiovascular events in patients with diabetic nephropathy (DN). METHODS: MGP T-138C polymorphism was assessed in 40 diabetic patients without nephropathy and 118 patients at different stages of DN, including patients on hemodialysis. Measurement of carotid intima-media thickness (cIMT) was performed using real-time B-mode ultrasonography...
October 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28732776/rad-gtpase-is-essential-for-the-regulation-of-bone-density-and-bone-marrow-adipose-tissue-in-mice
#16
Catherine N Withers, Drew M Brown, Innocent Byiringiro, Matthew R Allen, Keith W Condon, Jonathan Satin, Douglas A Andres
The small GTP-binding protein Rad (RRAD, Ras associated with diabetes) is the founding member of the RGK (Rad, Rem, Rem2, and Gem/Kir) family that regulates cardiac voltage-gated Ca(2+) channel function. However, its cellular and physiological functions outside of the heart remain to be elucidated. Here we report that Rad GTPase function is required for normal bone homeostasis in mice, as Rad deletion results in significantly lower bone mass and higher bone marrow adipose tissue (BMAT) levels. Dynamic histomorphometry in vivo and primary calvarial osteoblast assays in vitro demonstrate that bone formation and osteoblast mineralization rates are depressed, while in vitro osteoclast differentiation is increased, in the absence of Rad...
July 18, 2017: Bone
https://www.readbyqxmd.com/read/28727149/aortic-microcalcification-is-associated-with-elastin-fragmentation-in-marfan-syndrome
#17
Shaynah Wanga, Stijntje Hibender, Yanto Ridwan, Cindy van Roomen, Mariska Vos, Ingeborg van der Made, Nicole van Vliet, Romy Franken, Luigi Amjg van Riel, Maarten Groenink, Aeilko H Zwinderman, Barbara Jm Mulder, Carlie Jm de Vries, Jeroen Essers, Vivian de Waard
Marfan syndrome (MFS) is a connective tissue disorder in which aortic rupture is the major cause of death. MFS patients with an aortic diameter below the advised limit for prophylactic surgery (<5 cm) may unexpectedly experience an aortic dissection or rupture, despite yearly monitoring. Hence, there is a clear need for improved prognostic markers to predict such aortic events. We hypothesize that elastin fragments play a causal role in aortic calcification in MFS, and that microcalcification serves as a marker for aortic disease severity...
July 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28707070/functional-role-of-matrix-gla-protein-in-glioma-cell-migration
#18
Mu-Hui Fu, Chih-Yen Wang, Yun-Ti Hsieh, Kuan-Min Fang, Shun-Fen Tzeng
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor subtype. Despite that metastasis of GBM beyond the central nervous system (CNS) is rare, its malignancy is attributed to the highly infiltration trait, leading to the difficulty of complete surgical excision. Matrix gla protein (MGP) is a vitamin K-dependent small secretory protein, and functions as a calcification inhibitor. The involvement of MGP function in glioma cell dynamics remains to be clarified. The study showed that a low proliferative rat C6 glioma cell line named as C6-2 exhibited faster migratory and invasive capability compared to that observed in a high tumorigenic rat C6 glioma cell line (called as C6-1)...
July 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28686548/roles-of-vitamins-d-and-k-nutrition-and-lifestyle-in-low-energy-bone-fractures-in-children-and-young-adults
#19
Michał Karpiński, Janusz Popko, Katarzyna Maresz, Vladimir Badmaev, Sidney J Stohs
The research on skeletal system health in children and young adults, while recognizing the important role of calcium and vitamin D, goes beyond these nutritional standards. This review focuses on the role of vitamin K in combination with vitamin D and other factors in bone health. The current understanding is that maintaining bone health and prevention of low-energy fractures in any pediatric population includes nutritional factors combined with an active lifestyle. Calcium, vitamin D, and vitamin K supplementation contribute independently and collectively to bone health...
July 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28657840/therapeutic-warfarin-use-and-the-extrahepatic-functions-of-vitamin-k-dependent-proteins
#20
C J Donaldson, D J Harrington
The impact of warfarin therapy on the functions of extrahepatic vitamin K-dependent proteins (VKDP) is less clearly understood and less widely recognised in clinical practice than that on the hepatic counterparts (clotting factors II, VII, IX and X). Warfarin inhibits osteocalcin, an abundant extrahepatic VKDP involved in the mineralisation and maturation of bone and thus, primarily by this mechanism, may have an adverse effect on bone health. Whilst some studies do link warfarin use to an increase in osteoporosis and fracture risk others have not...
October 2017: British Journal of Biomedical Science
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