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https://www.readbyqxmd.com/read/28631230/sequence-analysis-of-chromosome-1-revealed-different-selection-patterns-between-chinese-wild-mice-and-laboratory-strains
#1
Fuyi Xu, Shixian Hu, Tianzhu Chao, Maochun Wang, Kai Li, Yuxun Zhou, Hongyan Xu, Junhua Xiao
Both natural and artificial selection play a critical role in animals' adaptation to the environment. Detection of the signature of selection in genomic regions can provide insights for understanding the function of specific phenotypes. It is generally assumed that laboratory mice may experience intense artificial selection while wild mice more natural selection. However, the differences of selection signature in the mouse genome and underlying genes between wild and laboratory mice remain unclear. In this study, we used two mouse populations: chromosome 1 (Chr 1) substitution lines (C1SLs) derived from Chinese wild mice and mouse genome project (MGP) sequenced inbred strains and two selection detection statistics: Fst and Tajima's D to identify the signature of selection footprint on Chr 1...
June 19, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28626250/association-between-changes-in-visual-evoked-magnetic-fields-and-non-motor-features-in-parkinson-s-disease
#2
Yoshiro Fujisawa, Tomomi Minato, Jun-Ichi Uemura, Minoru Hoshiyama, Hirohisa Watanabe, Masaaki Hirayama
Visual dysfunction can be caused by several abnormalities, including dysfunctions in the visual cortex and retina. Our aim was to investigate changes in visual evoked brain responses in the primary visual cortex associated with Parkinson's disease (PD). Sixteen healthy control subjects and ten patients with PD participated in this study. We assessed the visual evoked magnetic field (VEF) using magnetoencephalography (MEG). Checkerboard pattern reversal (CPR) and monotonous grating pattern (MGP) stimulations were used...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28617274/supporting-constructed-wetlands-in-p-removal-efficiency-from-surface-water
#3
Agnieszka Bus, Agnieszka Karczmarczyk
The research investigated the implementation of suspended reactive filters to support the phosphorus (P) removal efficiency of constructed wetlands (CWs). The reactive material (RM) used in this study was autoclaved aerated concrete (AAC). The laboratory experiment consists of four plastic boxes filled with the volume of 10 L of artificial P solution with three variants of RM mass to volume ratio: 1:1 (g:L), 5:1 (g:L), 10:1 (g:L), and the blind probe 0:1 (g:L) as a reference. AAC of different weights (10, 50 and 100 g) was wrapped in a filter bag, put into boxes, and suspended...
June 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28605143/enhanced-serum-levels-of-matrix-gla-protein-and-bone-morphogenetic-protein-in-acute-coronary-syndrome-patients
#4
Zafer Buyukterzi, Ummugulsum Can, Sertac Alpaydin, Asuman Guzelant, Sukru Karaarslan, Mehmet Mustu, Duygu Kocyigit, Kadri Murat Gurses
BACKGROUND: Vascular calcification has been found to be associated with increased risk of cardiovascular (CV) morbidity and mortality. Various bone-associated proteins have been suggested to be related with this process. In this study, we aimed to evaluate whether serum levels of bone morphogenic protein-4 (BMP-4) and matrix Gla protein (MGP) differed in patients who were found to have normal epicardial coronary arteries or a culprit lesion in the coronary angiography leading to acute coronary syndrome (ACS)...
June 12, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28595558/the-role-of-placental-carbonyl-reducing-enzymes-in-biotransformation-of-bupropion-and-4-methylnitrosamino-1-3-pyridyl-1-butanone
#5
Valentina M Fokina, Svetlana L Patrikeeva, Cheryl Oncken, Gary Dv Hankins, Mahmoud S Ahmed, Tatiana N Nanovskaya
BACKGROUND: Bupropion (BUP) has a potential to be an effective pharmacotherapy for smoking cessation during pregnancy. Smoking during pregnancy stimulates placental carbonyl reductases that catalyze the biotransformation of BUP. 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) is a potent carcinogen of cigarette smoke. Carbonyl reduction of NNK into 4-methylnitrosamino-1-(3-pyridyl)-1-butanol (NNAL) constitutes a major step in NNK detoxification. Thus, placentas of pregnant smokers on BUP therapy can become a site of drug-drug interaction...
June 6, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/28592418/growth-of-meibomian-gland-tissue-after-intraductal-meibomian-gland-probing-in-patients-with-obstructive-meibomian-gland-dysfunction
#6
Steven L Maskin, Whitney R Testa
PURPOSE: To investigate the impact of meibomian gland probing (MGP) on meibomian gland (MG) area from the upper lids of patients with obstructive meibomian gland dysfunction (o-MGD). METHODS: Retrospective study comparing pre-MGP/post-MGP non-contact infrared meibography results in patients with o-MGD, viewing signs of MG growth within total measurement field. RESULTS: Post-MGP meibography of 34 lids (19 patients, ≥4.5 to ≤12 months' follow-up) showed 41...
June 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28592319/high-dephosphorylated-uncarboxylated-mgp-in-hemodialysis-patients-risk-factors-and-response-to-vitamin-k2-a-pre-post-intervention-clinical-trial
#7
Mabel Aoun, Maha Makki, Hiba Azar, Hiam Matta, Dania Nehme Chelala
BACKGROUND: Vascular calcifications are highly prevalent in hemodialysis patients. Dephosphorylated-uncarboxylated MGP (dp-ucMGP) was found to increase in vitamin K-deficient patients and may be associated with vascular calcifications. Supplementation of hemodialysis patients with vitamin K2 (menaquinone-7) has been studied in Europe with a maximum 61% drop of dp-ucMGP levels. The aim of this study is to assess first the drop of dp-ucMGP in an Eastern Mediterranean cohort after vitamin K2 treatment and second the correlation between baseline dp-ucMGP and vascular calcification score...
June 7, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28550602/optimizing-the-modification-of-wood-waste-biochar-via-metal-oxides-to-remove-and-recover-phosphate-from-human-urine
#8
Kangning Xu, Chuke Zhang, Xiaomin Dou, Weifang Ma, Chengwen Wang
The recovery of phosphate from human urine has been considered as one of the most attractive benefits of urine source separation because P is an essential but limited macronutrient. This study investigated the approach to modify wood waste biochar via metal oxides aiming to recover phosphate from human urine to produce a value-added biochar. Results showed the phosphate removal ability was enhanced for the modified biochar pre-treated in modification solutions of MgCl2, AlCl3, CaCl2 and FeCl3, respectively, while natural biochar released phosphate to urine...
May 26, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28542410/gla-rich-protein-function-as-an-anti-inflammatory-agent-in-monocytes-macrophages-implications-for-calcification-related-chronic-inflammatory-diseases
#9
Carla S B Viegas, Rúben M Costa, Lúcia Santos, Paula A Videira, Zélia Silva, Nuna Araújo, Anjos L Macedo, António P Matos, Cees Vermeer, Dina C Simes
Calcification-related chronic inflammatory diseases are multifactorial pathological processes, involving a complex interplay between inflammation and calcification events in a positive feed-back loop driving disease progression. Gla-rich protein (GRP) is a vitamin K dependent protein (VKDP) shown to function as a calcification inhibitor in cardiovascular and articular tissues, and proposed as an anti-inflammatory agent in chondrocytes and synoviocytes, acting as a new crosstalk factor between these two interconnected events in osteoarthritis...
2017: PloS One
https://www.readbyqxmd.com/read/28533546/prostaglandin-e2-inhibits-matrix-mineralization-by-human-bone-marrow-stromal-cell-derived-osteoblasts-via-epac-dependent-camp-signaling
#10
Ali Mirsaidi, André N Tiaden, Peter J Richards
The osteoinductive properties of prostaglandin E2 (PGE2) and its signaling pathways have led to suggestions that it may serve as a potential therapeutic strategy for bone loss. However, the prominence of PGE2 as an inducer of bone formation is attributed primarily to findings from studies using rodent models. In the current study, we investigated the effects of PGE2 on human bone marrow stromal cell (hBMSC) lineage commitment and determined its mode of action. We demonstrated that PGE2 treatment of hBMSCs significantly altered the expression profile of several genes associated with osteoblast differentiation (RUNX2 and ALP) and maturation (BGLAP and MGP)...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28524237/in-vitro-dialysis-of-cytokine-rich-plasma-with-high-and-medium-cut-off-membranes-reduces-its-procalcific-activity
#11
Kevin Willy, Michael Hulko, Markus Storr, Rose Speidel, Julia Gauss, Ralf Schindler, Daniel Zickler
Recently developed high-flux (HF) dialysis membranes with extended permeability provide better clearance of middle-sized molecules such as interleukins (ILs). Whether this modulation of inflammation influences the procalcific effects of septic plasma on vascular smooth muscle cells (VSMCs) is not known. To assess the effects of high cut-off (HCO) and medium cut-off (MCO) membranes on microinflammation and in vitro vascular calcification we developed a miniature dialysis model. Plasma samples from lipopolysaccharide-spiked blood were dialyzed with HF, HCO, and MCO membranes in an in vitro miniature dialysis model...
May 19, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28487368/matrix-gla-protein-deficiency-impairs-nasal-septum-growth-causing-midface-hypoplasia
#12
Juliana Marulanda, Hazem Eimar, Marc D McKee, Michelle Berkvens, Valentin Nelea, Hassem Roman, Teresa Borrás, Faleh Tamimi, Mathieu Ferron, Monzur Murshed
Genetic and environmental factors may lead to abnormal growth of the orofacial skeleton affecting the overall structure of the face. In the current study, we investigated the craniofacial abnormalities in a mouse model for Keutel syndrome, a rare genetic disease caused by loss-of-function mutations in the matrix Gla protein (MGP) gene. Keutel syndrome patients show diffuse ectopic calcification of cartilaginous tissues and impaired midface development. Our comparative cephalometric analyses of micro-CT images revealed a severe midface hypoplasia in Mgp-/- mice...
May 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28464802/phosphate-binders-affect-vitamin-k-concentration-by-undesired-binding-an-in-vitro-study
#13
A Neradova, S P Schumacher, I Hubeek, P Lux, L J Schurgers, M G Vervloet
BACKGROUND: Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are less clear. There seems to be a difference in attenuation or delay in progression between different binders. In this in vitro experiment we tested whether phosphate binders could limit bioavailability of vitamin K2 by undesired binding. Vitamin K-deficiency limits activation of the vascular tissue mineralization inhibitor matrix γ-carboxyglutamate (Gla) protein (MGP) thereby exacerbating vascular calcification...
May 2, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28460948/enzymatic-biotransformation-of-polyphenolics-increases-antioxidant-activity-of-red-and-white-grape-pomace
#14
Isabela M Martins, Bruna S Roberto, Jeffrey B Blumberg, C-Y Oliver Chen, Gabriela A Macedo
Grape pomace (GP) is a polyphenolic-rich byproduct of wine production. As most polyphenolics are either bound to cellular matrices or present as free polymeric forms, treatment with hydrolytic enzymes may act to increase GP functionalities. The aim of this study was to examine the impact of tannase alone (T), pectinase plus cellulase (PC) or a mixture of them (TPC) on the hydrolysis of polyphenolics in red GP (RGP), white GP (WGP), and mixed GP (MGP) from Brazilian wine production, as well as antioxidant activity of the products...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28458247/quick-detection-and-quantification-of-iron-cyanide-complexes-using-fourier-transform-infrared-spectroscopy
#15
Magdalena Sut-Lohmann, Thomas Raab
The continuous release of persistent iron-cyanide (Fe-CN) complexes from various industrial sources poses a high hazard to the environment and indicates the necessity to analyze a considerable amount of samples. Conventional flow injection analysis (FIA) is a time and cost consuming method for cyanide (CN) determination. Thus, a rapid and economic alternative needs to be developed to quantify the Fe-CN complexes. 52 soil samples were collected at a former Manufactured Gas Plant (MGP) site in order to determine the feasibility of diffuse reflectance infrared Fourier spectroscopy (DRIFTS)...
August 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28450376/genome-wide-exome-analysis-of-cmv5-disparate-mouse-strains-that-differ-in-host-resistance-to-murine-cytomegalovirus-infection
#16
Alyssa Gillespie, Heather Lee, Catherine Robertson, Maya Cabot, Michael G Brown
Host resistance to murine cytomegalovirus (MCMV) varies in different strains of laboratory mice due to differences in expression of determinants that control and clear viral infection. The major histocompatibility complex (MHC) class I D(k) molecule is one such determinant that controls MCMV through the action of natural killer (NK) cells. The extent of NK cell-mediated Dk-dependent resistance to infection, however, varies in different mouse strains. The molecular genetic basis of this variation remains unclear...
April 26, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28411264/grecos-project-genotyping-recurrence-risk-of-stroke-the-use-of-genetics-to-predict-the-vascular-recurrence-after-stroke
#17
Israel Fernández-Cadenas, Maite Mendióroz, Dolors Giralt, Cristina Nafria, Elena Garcia, Caty Carrera, Cristina Gallego-Fabrega, Sophie Domingues-Montanari, Pilar Delgado, Marc Ribó, Mar Castellanos, Sergi Martínez, Marimar Freijo, Jordi Jiménez-Conde, Marta Rubiera, José Alvarez-Sabín, Carlos A Molina, Maria Angels Font, Marta Grau Olivares, Ernest Palomeras, Natalia Perez de la Ossa, Maite Martinez-Zabaleta, Jaime Masjuan, Francisco Moniche, David Canovas, Carlos Piñana, Francisco Purroy, Dolores Cocho, Inma Navas, Carlos Tejero, Nuria Aymerich, Natalia Cullell, Elena Muiño, Joaquín Serena, Francisco Rubio, Antoni Davalos, Jaume Roquer, Juan Francisco Arenillas, Joan Martí-Fábregas, Keith Keene, Wei-Min Chen, Bradford Worrall, Michele Sale, Adrià Arboix, Jerzy Krupinski, Joan Montaner
BACKGROUND AND PURPOSE: Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. METHODS: We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients...
May 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28364100/-expression-of-matrix-gla-protein-and-bone-morphogenetic-protein-2-in-renal-papillary-tissues-in-patients-with-calcium-oxalate-kidney-stones
#18
Min Zhu, Feng Zeng, Yu Cui, Xifeng Liu, Hequn Chen
To compare expression levels of matrix Gla protein (MGP) and bone morphogenetic protein 2 (BMP-2) in Randall's plaque of renal papillary tissues in patients with calcium oxalate kidney stones and the underlying mechanism for stone formation.
 Methods: A total of 30 samples of Randall's plaque in renal papillary tissues from patients with calcium oxalate kidney stones were collected from the Department of Urology of Xiangya Hospital of Central South University from April, 2015 to December, 2015 and served as an experimental group...
March 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28356433/circulating-vitamin-k-is-inversely-associated-with-incident-cardiovascular-disease-risk-among-those-treated-for-hypertension-in-the-health-aging-and-body-composition-study-health-abc
#19
M Kyla Shea, Sarah L Booth, Daniel E Weiner, Tina E Brinkley, Alka M Kanaya, Rachel A Murphy, Eleanor M Simonsick, Christina L Wassel, Cees Vermeer, Stephen B Kritchevsky
Background: A role for vitamin K in coronary artery calcification (CAC), a subclinical manifestation of cardiovascular disease (CVD), has been proposed because vitamin K-dependent proteins, including the calcification inhibitor matrix Gla protein (MGP), are present in vascular tissue. Observational studies found that low circulating phylloquinone (vitamin K-1) was associated with increased CAC progression, especially in persons treated for hypertension. It is unknown whether hypertension treatment modifies this putative role of vitamin K in clinical CVD risk...
May 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28340119/the-risk-of-nephrolithiasis-is-causally-related-to-inactive-matrix-gla-protein-a-marker-of-vitamin-k-status-a-mendelian-randomization-study-in-a-flemish-population
#20
Fang-Fei Wei, Lutgarde Thijs, Zhen-Yu Zhang, Lotte Jacobs, Wen-Yi Yang, Erika Salvi, Lorena Citterio, Nicholas Cauwenberghs, Tatiana Kuznetsova, Nadja E A Drummen, Azusa Hara, Paolo Manunta, Yan Li, Peter Verhamme, Karel Allegaert, Daniele Cusi, Cees Vermeer, Jan A Staessen
Background.: Vitamin K (VK)-dependent γ-glutamate carboxylation and serine phosphorylation activate matrix Gla protein (MGP) to a potent locally acting inhibitor of calcification. Nephrolithiasis represents a process of unwanted calcification associated with substantial mortality and high recurrence rates. We hypothesized that the risk of nephrolithiasis increases with VK shortage, as exemplified by higher plasma levels of desphospho-uncarboxylated MGP (dp-ucMGP). Methods...
March 15, 2017: Nephrology, Dialysis, Transplantation
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