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https://www.readbyqxmd.com/read/28104637/cortical-thickness-of-native-tibetans-in-the-qinghai-tibetan-plateau
#1
W Wei, X Wang, Q Gong, M Fan, J Zhang
BACKGROUND AND PURPOSE: High-altitude environmental factors and genetic variants together could have exerted their effects on the human brain. The present study was designed to investigate the cerebral morphology in high-altitude native Tibetans. MATERIALS AND METHODS: T1-weighted brain images were obtained from 77 Tibetan adolescents on the Qinghai-Tibetan Plateau (altitude, 2300-5300 m) and 80 matched Han controls living at sea level. Cortical thickness, curvature, and sulcus were analyzed by using FreeSurfer...
January 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28057489/representations-of-modality-general-valence-for-videos-and-music-derived-from-fmri-data
#2
Jongwan Kim, Svetlana V Shinkareva, Douglas H Wedell
This study tested for neural representations of valence that are shared across visual and auditory modalities referred to as modality-general representations. On a given trial participants made either affective or semantic judgments of short silent videos or music samples. For each modality valence was manipulated at three levels, positive, neutral, and negative, while controlling for the level of arousal. Whole-brain crossmodal identification of affect indicated the presence of modality-general valence representations that distinguished 1) positive from negative trials (signed valence) and 2) valenced from non-valenced trials (unsigned valence)...
January 2, 2017: NeuroImage
https://www.readbyqxmd.com/read/28057091/-resting-state-functional-magnetic-resonance-study-of-brain-function-changes-after-tips-operation-in-patients-with-liver-cirrhosis
#3
C Liu, H B Wang, Y Q Yu, M Q Wang, G B Zhang, L Y Xu, J M Wu
Objective: To investigate the brain function changes in cirrhosis patients after transjugular intrahepatic portosystemic shunt (TIPS), resting-state functional MRI (rs-fMRI) performed and fractional amplitude of low frequency fluctuation (fALFF) was analyzed. Methods: From January 2014 to February 2016, a total of 96 cirrhotic patients from invasive technology department and infection department in the First Affiliated Hospital of Anhui Medical University were selected , the blood ammonia data of 96 cirrhotic patients with TIPS operation in four groups were collected after 1, 3, 6 and 12 month, and all subjects performed rs-fMRI scans...
December 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28045690/clinical-case-of-the-month-a-49-year-old-man-who-presents-with-left-sided-weakness-an-update-on-ischemic-stroke
#4
Najy Masri, Rikki Weems, Falon Brown, Ben Andres, Fred Lopez
A 49 year-old man with a past medical history significant for essential hypertension, hyperlipidemia, and coronary artery disease status post percutaneous coronary intervention and stent placement in the right coronary artery in 2010 presented for evaluation of left hemiplegia. He was feeling well until three hours prior to presentation, at which time he fell while walking from his bedroom into the kitchen. After falling, he noticed that his left upper and lower extremities felt weak. He denied any symptoms preceding the fall or any loss of consciousness...
November 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28009087/distribution-and-characteristics-of-transactive-response-dna-binding-protein-43-kda-pathology-in-progressive-supranuclear-palsy
#5
Shunsuke Koga, Monica Sanchez-Contreras, Keith A Josephs, Ryan J Uitti, Neill Graff-Radford, Jay A van Gerpen, William P Cheshire, Zbigniew K Wszolek, Rosa Rademakers, Dennis W Dickson
BACKGROUND: This study aimed to determine the frequency of transactive response DNA binding protein 43 kDa pathology in PSP, the clinical features of patients with this pathology, and genetic risk factors for it. METHODS: Hippocampal sections were screened with immunohistochemistry for transactive response DNA binding protein 43 kDa in 945 PSP cases. A subset of 261 cases that were negative in hippocampus was screened in the amygdala. The density and disruption of this pathology, as well as regional tau burden, and clinical and genetic characteristics were analyzed...
December 23, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28008071/distinct-patterns-of-cerebral-cortical-thinning-in-schizophrenia-a-neuroimaging-data-driven-approach
#6
Genichi Sugihara, Naoya Oishi, Shuraku Son, Manabu Kubota, Hidehiko Takahashi, Toshiya Murai
Schizophrenia is an etiologically and clinically heterogeneous disorder. Although neuroimaging studies have revealed brain alterations in schizophrenia, most studies have assumed that the disorder is a single entity, neglecting the diversity of alterations observed in the disorder. The current study sought to explore the distinct patterns of altered cortical thickness in patients with schizophrenia and healthy individuals using a data-driven approach. Unsupervised clustering using self-organizing maps followed by a K-means algorithm was applied to regional cortical thickness data in 108 schizophrenia patients and 121 healthy controls...
December 22, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27898705/the-role-of-the-amygdala-in-facial-trustworthiness-processing-a-systematic-review-and-meta-analyses-of-fmri-studies
#7
Sara Santos, Inês Almeida, Bárbara Oliveiros, Miguel Castelo-Branco
BACKGROUND: Faces play a key role in signaling social cues such as signals of trustworthiness. Although several studies identify the amygdala as a core brain region in social cognition, quantitative approaches evaluating its role are scarce. OBJECTIVES: This review aimed to assess the role of the amygdala in the processing of facial trustworthiness, by analyzing its amplitude BOLD response polarity to untrustworthy versus trustworthy facial signals under fMRI tasks through a Meta-analysis of effect sizes (MA)...
2016: PloS One
https://www.readbyqxmd.com/read/27865969/age-related-alterations-in-functional-connectivity-patterns-during-working-memory-encoding-of-emotional-items
#8
Maryam Ziaei, Alireza Salami, Jonas Persson
Previous findings indicate age-related differences in frontal-amygdala connectivity during emotional processing. However, direct evidence for age differences in brain functional activation and connectivity during emotional processing and concomitant behavioral implications is lacking. In the present study, we examined the impact of aging on the neural signature of selective attention to emotional information during working memory (WM) encoding. Participants completed an emotional WM task in which they were asked to attend to emotional targets and ignore irrelevant distractors...
January 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/27864029/time-frequency-phase-synchrony-approaches-with-erps
#9
Selin Aviyente, Anne Tootell, Edward M Bernat
Time-frequency signal processing approaches are well-developed, and have been widely employed for the study of the energy distribution of event-related potential (ERP) data across time and frequency. Wavelet time-frequency transform (TFT) and Cohen's class of time-frequency distributions (TFD) are the most widely used in the field. While ERP TFT approaches have been most extensively developed for amplitude measures, reflecting the magnitude of regional neuronal activity, time-frequency phase-synchrony measures have gained increased utility in recent years for the assessment of functional connectivity...
January 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27859998/impact-of-alcohol-use-on-eeg-dynamics-of-response-inhibition-a-cotwin-control-analysis
#10
Jeremy Harper, Stephen M Malone, William G Iacono
Research indicates that alcohol misuse is associated with behavioral disinhibition, but the neurophysiological mechanisms governing this relationship remain largely unknown. Recent work suggests that successful inhibition and cognitive control involve electrophysiological theta-band dynamics, including medial frontal cortex (MFC) power enhancement and functional connectivity between the MFC and dorsal prefrontal cortex (dPFC) regions, which may be disrupted by alcohol misuse. In addition, research suggests that, compared to men, women are at heightened risk of experiencing the negative physical and neurocognitive correlates of drinking...
November 18, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27858707/neural-basis-of-apathy-in-patients-with-amnestic-mild-cognitive-impairment
#11
Hiroaki Kazui, Ryuichi Takahashi, Yuki Yamamoto, Kenji Yoshiyama, Hideki Kanemoto, Yukiko Suzuki, Shunsuke Sato, Shingo Azuma, Takashi Suehiro, Eku Shimosegawa, Kazunari Ishii, Toshihisa Tanaka
BACKGROUND: Although apathy is associated with damage to the frontal and temporal lobes in Alzheimer's disease (AD), the crucial regions for apathy in patients with amnestic mild cognitive impairment (aMCI) are unknown. OBJECTIVE: To identify brain regions associated with apathy in aMCI patients. METHODS: The subjects of this study were 98 aMCI patients who were entered in our dementia registry between March 1, 2009 and April 30, 2015 and who satisfied our criteria for aMCI...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27857886/effects-of-outcome-on-the-covariance-between-risk-level-and-brain-activity-in-adolescents-with-internet-gaming-disorder
#12
Xin Qi, Yongxin Yang, Shouping Dai, Peihong Gao, Xin Du, Yang Zhang, Guijin Du, Xiaodong Li, Quan Zhang
Individuals with internet gaming disorder (IGD) often have impaired risky decision-making abilities, and IGD-related functional changes have been observed during neuroimaging studies of decision-making tasks. However, it is still unclear how feedback (outcomes of decision-making) affects the subsequent risky decision-making in individuals with IGD. In this study, twenty-four adolescents with IGD and 24 healthy controls (HCs) were recruited and underwent functional magnetic resonance imaging while performing the balloon analog risk task (BART) to evaluate the effects of prior outcomes on brain activity during subsequent risky decision-making in adolescents with IGD...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27833549/impaired-white-matter-connections-of-the-limbic-system-networks-associated-with-impaired-emotional-memory-in-alzheimer-s-disease
#13
Xiaoshu Li, Haibao Wang, Yanghua Tian, Shanshan Zhou, Xiaohu Li, Kai Wang, Yongqiang Yu
Background: Discrepancies persist regarding retainment of emotional enhancement of memory (EEM) in mild cognitive impairment (MCI) and early Alzheimer's disease (AD) patients.In addition, the neural mechanisms are still poorly understood, little is known about emotional memory related changes in white matter (WM). Objective: To observe whether EEM is absent in amnestic MCI (aMCI) and AD patients, and to investigate if emotional memory is associated with WM connections and gray matters (GM) of the limbic system networks...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27776574/empathy-and-aversion-the-neural-signature-of-mentalizing-in-tourette-syndrome
#14
C M Eddy, A E Cavanna, P C Hansen
BACKGROUND: Previous studies suggest that adults with Tourette syndrome (TS) can respond unconventionally on tasks involving social cognition. We therefore hypothesized that these patients would exhibit different neural responses to healthy controls in response to emotionally salient expressions of human eyes. METHOD: Twenty-five adults with TS and 25 matched healthy controls were scanned using fMRI during the standard version of the Reading the Mind in the Eyes Task which requires mental state judgements, and a novel comparison version requiring judgements about age...
October 25, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27729856/aberrant-brain-regional-homogeneity-and-functional-connectivity-in-middle-aged-t2dm-patients-a-resting-state-functional-mri-study
#15
Daihong Liu, Shanshan Duan, Jiuquan Zhang, Chaoyang Zhou, Minglong Liang, Xuntao Yin, Ping Wei, Jian Wang
Type 2 diabetes mellitus (T2DM) has been associated with cognitive impairment. However, its neurological mechanism remains elusive. Combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, the present study aimed to investigate brain functional alterations in middle-aged T2DM patients, which could provide complementary information for the neural substrates underlying T2DM-associated brain dysfunction. Twenty-five T2DM patients and 25 healthy controls were involved in neuropsychological testing and structural and resting-state functional magnetic resonance imaging (rs-fMRI) data acquisition...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27720854/neural-correlates-of-judgments-of-learning-an-erp-study-on-metacognition
#16
Barbara C N Müller, Nike R H Tsalas, Hein T van Schie, Jörg Meinhardt, Joëlle Proust, Beate Sodian, Markus Paulus
Metacognitive assessment of performance has been revealed to be one of the most powerful predictors of human learning success and academic achievement. Yet, little is known about the functional nature of cognitive processes supporting judgments of learning (JOLs). The present study investigated the neural underpinnings of JOLs, using event-related brain potentials. Participants were presented with picture pairs and instructed to learn these pairs. After each pair, participants received a task cue, which instructed them to make a JOL (the likelihood of remembering the target when only presented with the cue) or to make a control judgment...
October 6, 2016: Brain Research
https://www.readbyqxmd.com/read/27704409/neural-mapping-of-guilt-a-quantitative-meta-analysis-of-functional-imaging-studies
#17
Anthony J Gifuni, Adam Kendal, Fabrice Jollant
Guilt is a self-conscious emotion associated with the negative appraisal of one's behavior. In recent years, several neuroimaging studies have investigated the neural correlates of guilt, but no meta-analyses have yet identified the most robust activation patterns. A systematic review of literature found 16 functional magnetic resonance imaging studies with whole-brain analyses meeting the inclusion criteria, for a total of 325 participants and 135 foci of activation. A meta-analysis was then conducted using activation likelihood estimation...
October 4, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27699680/lateral-and-medial-prefrontal-contributions-to-emotion-generation-by-semantic-elaboration-during-episodic-encoding
#18
Takumi Kaneda, Yayoi Shigemune, Takashi Tsukiura
Memories for emotion-laden stimuli are remembered more accurately than those for neutral stimuli. Although this enhancement reflects stimulus-driven modulation of memory by emotions, functional neuroimaging evidence of the interacting mechanisms between emotions generated by intentional processes, such as semantic elaboration, and memory is scarce. The present fMRI study investigated how encoding-related activation is modulated by emotions generated during the process of semantic elaboration. During encoding with fMRI, healthy young adults viewed neutral (target) pictures either passively or with semantic elaboration...
October 3, 2016: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/27680692/therapy-for-adult-social-anxiety-disorder-a-meta-analysis-of-functional-neuroimaging-studies
#19
Yuchen Li, Yajing Meng, Minlan Yuan, Ye Zhang, Zhengjia Ren, Yan Zhang, Hongru Zhu, Changjian Qiu, Wei Zhang
OBJECTIVE: We conducted a meta-analysis of the literature reporting neuroimaging in patients undergoing psychotherapy and pharmacotherapy for social anxiety disorder (SAD). DATA SOURCES: Using PubMed, MEDLINE, and Embase, we searched for English-language studies published between January 2000 and February 2015 with terms related to SAD, therapy, and neuroimaging. STUDY SELECTION: Twelve studies were included with a total of 295 subjects with SAD before and after therapy from January 2000 to February 2015...
November 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27660604/higher-adolescent-body-mass-index-is-associated-with-lower-regional-gray-and-white-matter-volumes-and-lower-levels-of-positive-emotionality
#20
James T Kennedy, Paul F Collins, Monica Luciana
Adolescent obesity is associated with an increased chance of developing serious health risks later in life. Identifying the neurobiological and personality factors related to increases in adiposity is important to understanding what drives maladaptive consummatory and exercise behaviors that result in obesity. Previous research has largely focused on adults with few findings published on interactions among adiposity, brain structure, and personality. In this study, Voxel Based Morphometry (VBM) was used to identify associations between gray and white matter volumes and increasing adiposity, as measured by Body Mass Index percentile (BMI%), in 137 adolescents (age range: 9-20 years, BMI% range: 5...
2016: Frontiers in Neuroscience
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