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medial frontal negativity

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https://www.readbyqxmd.com/read/28420951/shared-neural-mechanisms-for-the-prediction-of-own-and-partner-musical-sequences-after-short-term-piano-duet-training
#1
Claudia Lappe, Sabine Bodeck, Markus Lappe, Christo Pantev
Predictive mechanisms in the human brain can be investigated using markers for prediction violations like the mismatch negativity (MMN). Short-term piano training increases the MMN for melodic and rhythmic deviations in the training material. This increase occurs only when the material is actually played, not when it is only perceived through listening, suggesting that learning predictions about upcoming musical events are derived from motor involvement. However, music is often performed in concert with others...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28398341/the-cacna1c-risk-allele-rs1006737-is-associated-with-age-related-prefrontal-cortical-thinning-in-bipolar-i-disorder
#2
M G Soeiro-de-Souza, B Lafer, R A Moreno, F G Nery, T Chile, K Chaim, C da Costa Leite, R Machado-Vieira, M C G Otaduy, H Vallada
Calcium channels control the inflow of calcium ions into cells and are involved in diverse cellular functions. The CACNA1C gene polymorphism rs1006737 A allele has been strongly associated with increased risk for bipolar disorder (BD) and with modulation of brain morphology. The medial prefrontal cortex (mPFC) has been widely associated with mood regulation in BD, but the role of this CACNA1C polymorphism in mPFC morphology and brain aging has yet to be elucidated. One hundred seventeen euthymic BD type I subjects were genotyped for CACNA1C rs1006737 and underwent 3 T three-dimensional structural magnetic resonance imaging scans to determine cortical thickness of mPFC components (superior frontal cortex (sFC), medial orbitofrontal cortex (mOFC), caudal anterior cingulate cortex (cACC) and rostral anterior cingulate cortex (rACC))...
April 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28392711/dynamic-abnormalities-of-spontaneous-brain-activity-in-women-with-primary-dysmenorrhea
#3
Lingmin Jin, Xuejuan Yang, Peng Liu, Jinbo Sun, Fei Chen, Ziliang Xu, Wei Qin, Jie Tian
PURPOSE: This study aimed to investigate the regional spontaneous brain activity changes in primary dysmenorrhea (PD) patients in different phases of the menstrual cycle by regional homogeneity (ReHo) analysis. PATIENTS AND METHODS: Thirty-three PD patients and 32 healthy controls (HCs) separately received resting-state functional magnetic resonance imaging during menstrual phase and follicular phase (non-menstrual phase). Cox retrospective symptom scale (RSS), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were applied to assess related symptoms and emotions...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28390850/grey-matter-reduction-in-the-caudate-nucleus-in-patients-with-persistent-negative-symptoms-an-ale-meta-analysis
#4
REVIEW
Ying Li, Wen-Xiu Li, Dong-Jie Xie, Yi Wang, Eric F C Cheung, Raymond C K Chan
OBJECTIVES: In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS). METHOD: A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more stringent criterion of PNS. RESULTS: Significant grey matter reduction in the PNS group relative to controls was observed in the left caudate nucleus, the left precentral region, the left middle frontal region, the bilateral parahippocampal region, the left anterior cingulate region, the bilateral medial frontal gyrus, the thalamus and the insula...
April 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28371807/nicotine-withdrawal-induces-neural-deficits-in-reward-processing
#5
Jason A Oliver, David E Evans, Merideth A Addicott, Geoffrey F Potts, Thomas H Brandon, David J Drobes
Introduction: Nicotine withdrawal reduces neurobiological responses to non-smoking rewards. Insight into these reward deficits could inform the development of targeted interventions. This study examined the effect of withdrawal on neural and behavioral responses during a reward prediction task. Methods: Smokers (N = 48) attended two laboratory sessions following overnight abstinence. Withdrawal was manipulated by having participants smoke three regular nicotine (0...
March 27, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28341847/apoe-genotype-effects-on-intrinsic-brain-network-connectivity-in-patients-with-amnestic-mild-cognitive-impairment
#6
Zan Wang, Zhengjia Dai, Hao Shu, Xuhong Liao, Chunxian Yue, Duan Liu, Qihao Guo, Yong He, Zhijun Zhang
Whether and how the apolipoprotein E (APOE) ε4 genotype specifically modulates brain network connectivity in patients with amnestic mild cognitive impairment (aMCI) remain largely unknown. Here, we employed resting-state ('task-free') functional MRI and network centrality approaches to investigate local (degree centrality, DC) and global (eigenvector centrality, EC) functional integrity in the whole-brain connectome in 156 older adults, including 66 aMCI patients (27 ε4-carriers and 39 non-carriers) and 90 healthy controls (45 ε4-carriers and 45 non-carriers)...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28340448/structural-correlates-of-creative-thinking-in-patients-with-bipolar-disorder-and-healthy-controls-a-voxel-based-morphometry-study
#7
Pei-Chi Tu, Yi-Hsuan Kuan, Cheng-Ta Li, Tung-Ping Su
BACKGROUND: This study investigated the structural correlates of creative thinking in patients with bipolar disorder (BD) to understand the possible neural mechanism of creative thinking in BD. METHODS: We recruited 59 patients with BD I or BD II (35.3±8.5 y) and 56 age- and sex-matched controls (HCs; 34±7.4 y). Each participant underwent structural magnetic resonance imaging and evaluation of creative thinking, which was assessed using two validated tools: the Chinese version of the Abbreviated Torrance Test for Adults for divergent thinking and the Chinese Word Remote Associates Test for remote association...
March 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28324779/frontocingulate-cerebral-blood-flow-and-cerebrovascular-reactivity-associated-with-antidepressant-response-in-late-life-depression
#8
Margarita Abi Zeid Daou, Brian D Boyd, Manus J Donahue, Kimberly Albert, Warren D Taylor
BACKGROUND: Vascular pathology is common in late-life depression (LLD) and may contribute to alterations in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). In turn, such hemodynamic deficits may adversely affect brain function and clinical course. The goal of this study was to examine whether altered cerebral hemodynamics in depressed elders predicted antidepressant response. METHODS: 21 depressed elders completed cranial 3T MRI, including a pseudo-continuous Arterial Spin Labeling (pcASL) acquisition on both room air and during a hypercapnia challenge...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28301866/abnormal-spontaneous-brain-activity-in-acute-low-back-pain-revealed-by-resting-state-functional-mri
#9
Shan-Shan Zhang, Wen Wu, Jian-Ming Yang, Chu-Huai Wang
OBJECTIVE: Neuroimaging studies have revealed that low-back pain (LBP) alters spatiotemporal dynamics of the blood oxygen level-dependent signal in response to persistent noxious stimulus. This study aimed to investigate changes in spontaneous neural activity of various brain regions in acute LBP using resting-state functional magnetic resonance imaging and amplitude of low-frequency fluctuation (ALFF). DESIGN: Twelve healthy subjects underwent two separate resting-state functional magnetic resonance imaging scans at health status as baseline and after intramuscular injection of hypertonic saline (0...
April 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28294134/influence-of-familial-risk-for-depression-on-cortico-limbic-connectivity-during-implicit-emotional-processing
#10
Carolin Wackerhagen, Torsten Wüstenberg, Sebastian Mohnke, Susanne Erk, Ilya M Veer, Johann D Kruschwitz, Maria Garbusow, Lydia Romund, Kristina Otto, Janina I Schweiger, Heike Tost, Andreas Heinz, Andreas Meyer-Lindenberg, Henrik Walter, Nina Romanczuk-Seiferth
Imbalances in cortico-limbic activity and functional connectivity (FC) supposedly underlie biased emotional processing and present putative intermediate phenotypes (IPs) for major depressive disorder (MDD). To prove the validity of these IPs, we assessed them in familial risk during implicit emotional processing. To provide comparable data to previous studies and additionally elucidate the implications of altered functional connectivity, amygdala FC was assessed across and between task conditions. In 70 healthy first-degree relatives of MDD patients and 70 controls, brain activity and seed-based amygdala FC were assessed during an angry and fearful faces matching task for fMRI...
March 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28288855/alterations-in-prefrontal-connectivity-in-schizophrenia-assessed-using-diffusion-magnetic-resonance-imaging
#11
Vicente Molina, Alba Lubeiro, Oscar Soto, Margarita Rodriguez, Aldara Álvarez, Rebeca Hernández, Rodrigo de Luis-García
BACKGROUND: Spatial and biological characteristics of structural frontal disconnectivity in schizophrenia remain incompletely understood. Simultaneous streamline count (SC) and fractional anisotropy (FA) analyses may yield relevant complementary information to this end. METHODS: Using 3T diffusion magnetic resonance imaging both SC and FA were calculated for the tracts linking lateral and medial subregions of prefrontal cortex (PFC) to cingulate, hippocampus, caudate and thalamus in 27 schizophrenia patients (14 first-episodes) and 27 controls...
March 10, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28268177/prospective-relations-between-resting-state-connectivity-of-parietal-subdivisions-and-arithmetic-competence
#12
Gavin R Price, Darren J Yeo, Eric D Wilkey, Laurie E Cutting
The present study investigates the relation between resting-state functional connectivity (rsFC) of cytoarchitectonically defined subdivisions of the parietal cortex at the end of 1st grade and arithmetic performance at the end of 2nd grade. Results revealed a dissociable pattern of relations between rsFC and arithmetic competence among subdivisions of intraparietal sulcus (IPS) and angular gyrus (AG). rsFC between right hemisphere IPS subdivisions and contralateral IPS subdivisions positively correlated with arithmetic competence...
February 22, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28266002/voxel-based-mapping-of-grey-matter-volume-and-glucose-metabolism-profiles-in-amyotrophic-lateral-sclerosis
#13
M-S Buhour, F Doidy, A Mondou, A Pélerin, L Carluer, F Eustache, F Viader, B Desgranges
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unclear. Several studies using anatomical MRI yielded a number of discrepancies in their results, and a few PET studies investigated the effect of ALS on cerebral glucose metabolism. The aim of this study was threefold: to highlight the patterns of grey matter (GM) atrophy, hypometabolism and hypermetabolism in patients with ALS, then to understand the neurobehavioral significance of hypermetabolism and, finally, to investigate the regional differences between the morphologic and functional changes in ALS patients, using a specially designed voxel-based method...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28226306/task-dependent-modulation-of-amygdala-connectivity-in-social-anxiety-disorder
#14
Lora Minkova, Ronald Sladky, Georg S Kranz, Michael Woletz, Nicole Geissberger, Christoph Kraus, Rupert Lanzenberger, Christian Windischberger
Increased amygdala activation is consistently found in patients suffering from social anxiety disorder (SAD), a psychiatric condition characterized by an intense fear of social situations and scrutiny. Disruptions in the amygdalar-frontal network in SAD may explain the inability of frontal regions to appropriately down-regulate amygdalar hyper-activation. In this study, we measured 15 SAD patients and 15 healthy controls during an affective counting Stroop task with emotional faces to assess the interaction of affective stimuli with a cognitive task in SAD, as well as to investigate the causal interactions between the amygdala and the medial orbitofrontal cortex (OFC) using dynamic causal modeling (DCM)...
February 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28223812/resting-state-functional-connectivity-changes-within-the-default-mode-network-and-the-salience-network-after-antipsychotic-treatment-in-early-phase-schizophrenia
#15
Yingchan Wang, Weijun Tang, Xiaoduo Fan, Jianye Zhang, Daoying Geng, Kaida Jiang, Dianming Zhu, Zhenhua Song, Zeping Xiao, Dengtang Liu
OBJECTIVE: Abnormal resting-state functional connectivity (FC), particularly in the default mode network (DMN) and the salience network (SN), has been reported in schizophrenia, but little is known about the effects of antipsychotics on these networks. The purpose of this study was to examine the effects of atypical antipsychotics on DMN and SN and the relationship between these effects and symptom improvement in patients with schizophrenia. METHODS: This was a prospective study of 33 patients diagnosed with schizophrenia and treated with antipsychotics at Shanghai Mental Health Center...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28197859/imaging-the-up-s-and-down-s-of-emotion-regulation-in-lifetime-depression
#16
Sina Radke, Felix Hoffstaedter, Leonie Löffler, Lydia Kogler, Frank Schneider, Jens Blechert, Birgit Derntl
Reappraisal is a particularly effective strategy for influencing emotional experiences, specifically for reducing the impact of negative stimuli. Although depression has repeatedly been linked to dysfunctional behavioral and neural emotion regulation, prefrontal and amygdala engagement seems to vary with clinical characteristics and the specific regulation strategy used. Whereas previous neuroimaging research has focused on down-regulating reactions to emotionally evocative scenes, the current study compared up- and down-regulation in response to angry facial expressions in patients with depression and healthy individuals...
February 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28165888/voxel-based-morphometry-of-disgust-sensitivity
#17
Albert Wabnegger, Sonja Übel, Anne Schienle
BACKGROUND: Difficulties with the regulation of negative affect have been extensively studied in neuroimaging research. However, dysregulation of a specific emotion, disgust, has hardly been investigated. In the present study, we used voxel-based morphometry to identify whether gray matter volume (GMV) of frontal regions is correlated with personality traits associated with general and disgust-specific emotion regulation difficulties. METHOD: We analyzed T1-weighted images of 49 females (mean age = 22...
February 6, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28155138/cerebellar-neural-circuits-involving-executive-control-network-predict-response-to-group-cognitive-behavior-therapy-in-social-anxiety-disorder
#18
MinlanYuan, Yajing Meng, Yan Zhang, Xiaojing Nie, Zhengjia Ren, Hongru Zhu, Yuchen Li, Su Lui, Qiyong Gong, Changjian Qiu, Wei Zhang
Some intrinsic connectivity networks including the default mode network (DMN) and executive control network (ECN) may underlie social anxiety disorder (SAD). Although the cerebellum has been implicated in the pathophysiology of SAD and several networks relevant to higher-order cognition, it remains unknown whether cerebellar areas involved in DMN and ECN exhibit altered resting-state functional connectivity (rsFC) with cortical networks in SAD. Forty-six patients with SAD and 64 healthy controls (HC) were included and submitted to the baseline resting-state functional magnetic resonance imaging (fMRI)...
February 2, 2017: Cerebellum
https://www.readbyqxmd.com/read/28153978/grizzly-bear-ursus-arctos-horribilis-locomotion-forelimb-joint-mechanics-across-speed-in-the-sagittal-and-frontal-planes
#19
Catherine L Shine, Charles T Robbins, O Lynne Nelson, Craig P McGowan
The majority of terrestrial locomotion studies have focused on parasagittal motion and paid less attention to forces or movement in the frontal plane. Our previous research has shown that grizzly bears produce higher medial ground reaction forces (lateral pushing from the animal) than would be expected for an upright mammal, suggesting frontal plane movement may be an important aspect of their locomotion. To examine this, we conducted an inverse dynamics analysis in sagittal and frontal planes, using ground reaction forces and position data from three high speed cameras of four adult female grizzly bears...
February 2, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28128347/attention-bias-of-avoidant-individuals-to-attachment-emotion-pictures
#20
Ying Liu, Yi Ding, Luluzi Lu, Xu Chen
How attachment style affects emotion processing is tightly connected with individuals' attention bias. This experiment explored avoidant individuals' attentional engagement and attentional disengagement using a cue-target paradigm in fMRI. The experimental group consisted of 17 avoidant participants, while the control group consisted of 16 secure participants; these were identified by the Experiences in Close Relationships inventory and the Relationship Questionnaire. Each reacted to pictures of positive parent-child attachment, negative parent-child attachment, positive romantic attachment, negative romantic attachment, and neutral non-attachment...
January 27, 2017: Scientific Reports
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