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Madita Hoy, Bernhard Strauß, Christoph Kröger, Katja Brenk-Franz
The New Sexual Satisfaction Scale (NSSS) is an internationally established questionnaire for assessing sexual satisfaction. It is based on 2 subscales (ego-centered and partner- and sexual activity-centered sexual satisfaction). The aim of the study was to evaluate the German short version of the questionnaire (NSSS-SD) in a representative sample (N=2524). In addition, relationships between sexual satisfaction and sociodemographic factors (age, sex, education) and characteristics of partnership and sexuality (relationship satisfaction, coitus frequency, number of sexual partners) were examined...
June 22, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
Isolina Maria Alberto Fruet, Graziele de Lima Dalmolin, Edison Luiz Devos Barlem, Rosangela Marion da Silva, Rafaela Andolhe
OBJECTIVE: To verify the applicability of the adapted Moral Distress Scale in the nursing setting of the hemato-oncology sector of a university hospital. METHOD: Cross-sectional study conducted with 46 nursing workers of a university hospital in the southern region of Brazil with data collected between December 2014 and March 2015 by means of the adapted Moral Distress Scale. Factor analysis, Cronbach's alpha, and descriptive statistics were used to analyze the data...
June 7, 2018: Revista Gaúcha de Enfermagem
Jamie W Sleigh, Susana Vacas, Alana M Flexman, Pekka O Talke
BACKGROUND: The depth of dexmedetomidine-induced sedation is difficult to assess without arousing the patient. We evaluated frontal electroencephalogram (EEG) as an objective measure of dexmedetomidine-induced sedation. Our aims were to characterize the response patterns of EEG during a wide range of dexmedetomidine-induced sedation and to determine which spectral power best correlated with assessed levels of dexmedetomidine-induced sedation. METHODS: Sedline EEG sensor was positioned on the forehead of 16 volunteers...
June 20, 2018: Anesthesia and Analgesia
Changli Wang, Xihui Bai, Shiyu Liu, Jing Wang, Zhuo Su, Wenjuan Zhang, Diaodiao Bu, Yonggang Yan, Xiao Song
In this study, RNA-seq technology was used to study the protective effect of Compound Longmaining (CLMN) decoction on acute myocardial infarction (AMI). The results of RNA-seq showed that the CLMN decoction has a regulatory effect on the 51 differentially expressed genes (DEGs), which were mainly enriched in the 7 pathways revealed by KEGG analysis. In addition, qPCR technology was used to verify the expression of chemokine (C-C motif) ligand 6 (Ccl6), chemokine (C-C motif) receptor 5 (Ccr5), integrin alpha M (Itgam), neutrophil cytosolic factor 1 (Ncf1), and matrix metallopeptidase 9 (Mmp9)...
June 18, 2018: Journal of Pharmaceutical and Biomedical Analysis
Alissa J Ellis, Giulia Salgari, David Miklowitz, Sandra K Loo
Frontal EEG asymmetry, relatively greater left-than-right frontal activity (rLFA), has been associated with mood symptoms and approach versus withdrawal behaviors. Distress tolerance (DT), a transdiagnostic behavior, has yet to be examined as an approach behavior using rLFA. Adolescents (N = 20; M age = 14.53, SD = 2.09) completed a frustrating mirror-tracing task which provided an index of DT. Higher resting rLFA was associated with lower DT. The results are the first to identify a relationship between cortical activation and distress tolerance in adolescents...
June 6, 2018: Psychiatry Research
Xiang-Fan Chen, Xiao-Li Li, Jin-Xin Liu, Jing Xu, Yan-Yan Zhao, Min Yang, Yan Zhang
BACKGROUND: This study aimed to study the osteo-preservative effects of captopril, an inhibitor on angiotensin-converting enzyme (ACE), on bone mass, micro-architecture and histomorphology as well as the modulation of captopril on skeletal renin-angiotensin system (RAS) and regulators for bone metabolism in mice with bilateral orchidectomy. METHODS: The orchidectomized (ORX) mice were orally administered with vehicle or captopril at low dose (10 mg/kg) and high dose (50 mg/kg) for six weeks...
February 7, 2018: Pharmacological Reports: PR
Mary E Air, Julian R Harrison, Joseph T Nguyen, Bryan T Kelly, Eric A Bogner, Peter J Moley
BACKGROUND: Prior studies have compared radiographic and computed tomography (CT) imaging for evaluation of pre-arthritic hip pain. However, the inter-modality, inter-rater, and intra-rater consistencies of those parameters have not been investigated. OBJECTIVE: To determine if radiographs with an anteroposterior pelvis view and 45°-Dunn lateral view reliably correlate with CT in the context of lateral center edge (LCE), Tonnis, alpha, and beta angle measurements for femoroacetabular impingement or hip dysplasia diagnosis...
June 19, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Wesley Thevathasan, Elena Moro
Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) is an experimental treatment for in Parkinson's disease (PD) which offers a fairly circumscribed benefit for gait freezing and perhaps balance impairment. The benefit on gait freezing is variable and typically incomplete, which may reflect that the clinical application is yet to be optimised or reflect a fundamental limitation of the therapeutic mechanism. Thus, a better understanding of the therapeutic mechanism of PPN DBS may guide the further development of this therapy...
June 19, 2018: Neurobiology of Disease
In-Sung Song, Yu Jeong Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Nam-Chul Ha, MyungGeun Shin, Kyung Soo Ko, Byoung Doo Rhee, Sungbo Shim, Sung-Wuk Jang, Jin Han
Multiple myeloma (MM) is a neoplastic plasma cell disorder with high disease recurrence rates. Novel therapeutic approaches capable of improving outcomes in patients with MM are urgently required. The AKT signalling plays a critical regulatory role in MM pathophysiology, including survival, proliferation, metabolism, and has emerged as a key therapeutic target. Here, we identified a novel AKT inhibitor, HS1793, and defined its mechanism of action and clinical significance in MM. HS1793 disrupted the interaction between AKT and heat shock protein 90, resulting in protein phosphatase 2A-modulated phosphorylated-AKT (p-AKT) reduction...
June 19, 2018: Cancer Letters
Monica M Gaudier-Diaz, Adam H Haines, Ning Zhang, A Courtney DeVries
Social isolation presents a risk factor and worsens outcome to cerebrovascular diseases; however, the underlying mechanisms remain underspecified. This study examines the effect of social environment on microglial reactivity after global cerebral ischemia, to test the hypothesis that social isolation leads to greater microglial responses. Adult female and male mice were pair-housed or socially isolated for one week prior to cardiac arrest/cardiopulmonary resuscitation (CA/CPR) or the sham procedure, and following either 2 or 24 h of reperfusion, microglia samples were enriched and analyzed for gene expression...
June 19, 2018: Physiology & Behavior
Samuel J Smith, Anitta R Y Kamara, Foday Sahr, Mohamed Samai, Alpha S Swaray, Didier Menard, Marian Warsame
Currently, the national malaria control programme (NMCP) of Sierra Leone recommends artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) as first- and second-line treatment for uncomplicated malaria, respectively, and artesunate + sulfadoxine-pyrimethamine (SP) for intermittent preventive treatment during pregnancy and for infants. In 2016, the NMCP conducted a study to assess the clinical and parasitological responses of children under five years to ASAQ, AL and dihydroartemisinin-piperaquine (DHA/PPQ) according to the WHO protocol...
June 19, 2018: Acta Tropica
Noelle E Carlozzi, Phillip A Ianni, David S Tulsky, Tracey A Brickell, Rael T Lange, Louis M French, David Cella, Michael A Kallen, Jennifer A Miner, Anna L Kratz
OBJECTIVE: To examine the reliability and validity of Patient Reported Outcomes Measurement Information System (PROMIS) measures of sleep disturbance and fatigue in TBI caregivers and to determine the severity of fatigue and sleep disturbance in these caregivers. DESIGN: Cross-sectional survey data collected through an online data capture platform. SETTING: Four rehabilitation hospitals and Walter Reed National Military Medical Center. PARTICIPANTS: Caregivers (N=560) of civilians (n=344) and service member/veterans (n=216) with TBI...
June 19, 2018: Archives of Physical Medicine and Rehabilitation
Yichen Wang, Priyha Mahesh, Yan Wang, Samuel G Novo, Mahbubul H Shihan, Brielle Hayward-Piatkovskyi, Melinda K Duncan
The appropriate spatial and temporal regulation of canonical Wnt signaling is vital for eye development. However, the literature often conflicts on the distribution of canonical Wnt signaling in the eye. Here, using a sensitive mouse transgenic reporter line, we report a detailed re-evaluation of the spatiotemporal dynamics of canonical Wnt signaling in the developing eye. Canonical Wnt activity was dynamic in the optic vesicle and later in the retina, while it was absent from the ectodermal precursors of the lens and corneal epithelium...
June 19, 2018: Experimental Eye Research
Tamara Tyrinova, Olga Leplina, Sergey Mishinov, Marina Tikhonova, Anton Kalinovskiy, Sergey Chernov, Evgeniya Dolgova, Vyacheslav Stupak, Evgeniya Voronina, Sergey Bogachev, Ekaterina Shevela, Alexander Ostanin, Elena Chernykh
Besides initiation of tumor-specific T cell immunity, dendritic cells (DCs) are endowed with tumoricidal activity. Previously, we showed that monocyte-derived DCs of high-grade glioma patients generated in the presence of interferon alpha (IFNα) (IFN-DCs) have impaired cytotoxic activity against tumor necrosis factor alpha (TNFα)-sensitive HEp-2 tumor cells. Herein, we demonstrate that decreased transmembrane TNFα (tmTNFα) expression, but not soluble TNFα (sTNFα) production by high-grade glioma patient IFN-DCs, determines the defective tumoricidal activity against TNFα-sensitive HEp-2 cells...
June 22, 2018: Journal of Interferon & Cytokine Research
Mikhail Lebyodkin, Kékéli Amouzou, Tatiana Lebedkina, Thiebaud Richeton, Amandine Roth
Current progress in the prediction of mechanical behavior of solids requires understanding of spatiotemporal complexity of plastic flow caused by self-organization of crystal defects. It may be particularly important in hexagonal materials because of their strong anisotropy and combination of different mechanisms of plasticity, such as dislocation glide and twinning. These materials often display complex behavior even on the macroscopic scale of deformation curves, e.g., a peculiar three-stage elastoplastic transition, the origin of which is a matter of debates...
June 22, 2018: Materials
Muhammad Salman, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Jeffery Hughes, Junaid Habib Khan, Khalid Hussain
OBJECTIVE: The objective of the current study was to develop an Urdu version of the International Prostate Symptom Score (IPSS-U) and validate it for Pakistani patients suffering from lower urinary tract symptoms (LUTS). MATERIAL AND METHODS: IPSS-U was developed by a two-step forward and back translation and to evaluate its psychometric properties, a prospective study involving patients suffering from LUTS (n=267) was conducted at Outpatient Urology Department, Mayo Hospital, Lahore, Pakistan...
July 2018: Turkish Journal of Urology
Martin E M Parsons, Paulina B Szklanna, Jose A Guererro, Kieran Wynne, Feidhlim Dervin, Karen O'Connell, Seamus Allen, Karl Egan, Cavan Bennett, Christopher McGuigan, Cedric Gheveart, Fionnuala Ní Áinle, Patricia B Maguire
Upon activation, platelets release a powerful cocktail of soluble and vesicular signals, collectively termed the 'platelet releasate' (PR). Although several studies have used qualitative/quantitative proteomic approaches to characterise PR; with debated content and significant inter-individual variability reported, confident and reliable insights have been hindered. Using label-free quantitative (LFQ)-proteomics analysis, we provide a reproducible, quantifiable investigation of the 1U/ml thrombin-induced PR from 32 healthy adults...
June 22, 2018: Proteomics
Ju-Hye Yang, Esther Lee, BoHyoung Lee, Won-Kyung Cho, Jin Yeul Ma, Kwang-Il Park
Artemisia apiacea Hance is a traditional herbal medicine used for treating eczema and jaundice in Eastern Asia including China, Korea, and Japan. However, the biological and pharmacological actions of Artemisia apiacea Hance in atopic dermatitis (AD) are not fully understood. An ethanolic extract of Artemisia apiacea Hance (EAH) was tested in vitro and in vivo to investigate its anti-inflammatory activity and anti-atopic dermatitis effects. The results showed that EAH dose-dependence inhibited production of regulated on activation, normal T-cell expressed and secreted (RANTES), interleukin (IL)-6, IL-8, and thymus and activation-regulated chemokine (TARC)...
June 22, 2018: Nutrients
Maciej Wójcik, Agata Krawczyńska, Hanna Antushevich, Andrzej Przemysław Herman
The growth hormone (GH) plays a key role in the regulation of metabolic processes in an organism. Determination of the correct structure and functioning of the growth hormone receptor (GHR) allowed for a more detailed research of its post-receptor regulators, which substantially influences its signal transduction. This review is focused on the description of the post-receptor inhibitors of the GHR-JAK2-STAT pathway, which is one of the most important pathways in the transduction of the somatotropic axis signal...
June 22, 2018: International Journal of Molecular Sciences
Douglas Jackson, Kylie Connolly, Romeo Batacan, Kimberly Ryan, Rebecca Vella, Andrew Fenning
(−)-Epicatechin (E) is a flavanol found in green tea and cocoa and has been shown to attenuate tumour necrosis factor alpha (TNF-α)-mediated inflammation, improve nitric oxide levels, promote endothelial nitric oxide synthase (eNOS) activation and inhibit NADPH oxidase. This study investigated the effect of 28 days of low epicatechin dosing (1 mg/kg/day) on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Wistar rats (n = 120, 8 weeks of age) underwent uninephrectomy and were randomised into four groups (uninephrectomy (UNX), UNX + E, DOCA, DOCA + E)...
June 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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