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Head cancer physical activity

Gopal Iyer, James Price, Shay Bourgeois, Eric Armstrong, Shyhmin Huang, Paul M Harari
BACKGROUND: The epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and several other human cancers. Monoclonal antibodies, such as cetuximab that block EGFR signaling, have emerged as valuable molecular targeting agents in clinical cancer therapy. Prolonged exposure to cetuximab can result in cells acquiring resistance by a process that remains incompletely understood. METHODS: In this study, we analyzed the immediate early molecular response of cetuximab on physical interactions between EGFR and Insulin growth factor 1 like receptor (IGF-1R) in head and neck cancer cells that are resistant to cetuximab...
October 6, 2016: BMC Cancer
Hoda Badr, Krista Herbert, Batya Reckson, Hope Rainey, Aminah Sallam, Vishal Gupta
In head and neck cancer (HNC), couple-based interventions may be useful for facilitating treatment completion, patient rehabilitation, and improving both partners' quality of life. With the goal of identifying targets for future interventions, we conducted a qualitative study to understand patient and spouse unmet needs and relationship challenges during curative radiotherapy for HNC. Semistructured interviews were conducted with six HNC patients (83% male) and six spouses (83% female) within 6 months of completing treatment...
July 2016: Journal of Psychosocial Oncology
Maria Filippousi, Stuart Turner, Karen Leus, Panoraia I Siafaka, Eirini D Tseligka, Matthias Vandichel, Stavroula G Nanaki, Ioannis S Vizirianakis, Dimitrios N Bikiaris, Pascal Van Der Voort, Gustaaf Van Tendeloo
Nanoscale Zr-based metal organic frameworks (MOFs) UiO-66 and UiO-67 were studied as potential anticancer drug delivery vehicles. Two model drugs were used, hydrophobic paclitaxel and hydrophilic cisplatin, and were adsorbed onto/into the nano MOFs (NMOFs). The drug loaded MOFs were further encapsulated inside a modified poly(ε-caprolactone) with d-α-tocopheryl polyethylene glycol succinate polymeric matrix, in the form of microparticles, in order to prepare sustained release formulations and to reduce the drug toxicity...
July 25, 2016: International Journal of Pharmaceutics
Stefanus Gunawan, Chloe Ten Broeke, Peter van de Ven, Marijn Arnoldussen, Gertjan Kaspers, Saskia Mostert
BACKGROUND: This study assessed parental experiences with chemotherapy-induced alopecia among children with cancer treated at an Indonesian academic hospital. MATERIALS AND METHODS: Fifty parents of childhood cancer patients were interviewed using semi-structured questionnaires. RESULTS: The moment that hair fell out was the moment that parents (84%) had to admit their child had cancer. Alopecia was a traumatizing painful experience (46%)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Steven C Moore, I-Min Lee, Elisabete Weiderpass, Peter T Campbell, Joshua N Sampson, Cari M Kitahara, Sarah K Keadle, Hannah Arem, Amy Berrington de Gonzalez, Patricia Hartge, Hans-Olov Adami, Cindy K Blair, Kristin B Borch, Eric Boyd, David P Check, Agnès Fournier, Neal D Freedman, Marc Gunter, Mattias Johannson, Kay-Tee Khaw, Martha S Linet, Nicola Orsini, Yikyung Park, Elio Riboli, Kim Robien, Catherine Schairer, Howard Sesso, Michael Spriggs, Roy Van Dusen, Alicja Wolk, Charles E Matthews, Alpa V Patel
IMPORTANCE: Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE: To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking. DESIGN, SETTING, AND PARTICIPANTS: We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004)...
June 1, 2016: JAMA Internal Medicine
Aaron D Falchook, Rebecca Green, Mary E Knowles, Robert J Amdur, William Mendenhall, David N Hayes, Juneko E Grilley-Olson, Jared Weiss, Bryce B Reeve, Sandra A Mitchell, Ethan M Basch, Bhishamjit S Chera
IMPORTANCE: Agreement between patient- and practitioner-reported toxic effects during chemoradiotherapy for head and neck cancer is unknown. OBJECTIVE: To compare patient-reported symptom severity and practitioner-reported toxic effects among patients receiving chemoradiotherapy for head and neck cancer. DESIGN, SETTING, AND PARTICIPANTS: Forty-four patients participating in a phase 2 trial of deintensified chemoradiotherapy for oropharyngeal carcinoma were included in the present study (conducted from February 8, 2012, to March 2, 2015)...
June 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
Laís Rigoni, Raphaella Falco Bruhn, Rafael De Cicco, Jossi Ledo Kanda, Leandro Luongo Matos
INTRODUCTION: Head and neck cancer represents 3% of all the types of malignant neoplasms and squamous cell carcinoma (SCC) is responsible for 90% of these cases. There have been some studies evaluating the quality of life of these patients, but little is known about the physical and emotional effects on their caregivers. PURPOSE: To evaluate the quality of life of patients with head and neck cancer and their caregivers by applying validated questionnaires. METHODS: Thirty patients with advanced tumors (SCC stage III or IV) and their 30 caregivers were included...
April 11, 2016: Brazilian Journal of Otorhinolaryngology
Olga P Nyssen, Stephanie J C Taylor, Geoff Wong, Elizabeth Steed, Liam Bourke, Joanne Lord, Carol A Ross, Sheila Hayman, Victoria Field, Ailish Higgins, Trisha Greenhalgh, Catherine Meads
BACKGROUND: Writing therapy to improve physical or mental health can take many forms. The most researched model of therapeutic writing (TW) is unfacilitated, individual expressive writing (written emotional disclosure). Facilitated writing activities are less widely researched. DATA SOURCES: Databases, including MEDLINE, EMBASE, PsycINFO, Linguistics and Language Behaviour Abstracts, Allied and Complementary Medicine Database and Cumulative Index to Nursing and Allied Health Literature, were searched from inception to March 2013 (updated January 2015)...
April 2016: Health Technology Assessment: HTA
A Simon Pickard, Ruixuan Jiang, Hsiang-Wen Lin, Sarah Rosenbloom, David Cella
PURPOSE: The objective of this study was to compare the health-related quality of life (HRQL) burden across different types of advanced cancer with the use of 2 widely used patient-reported outcome measures, the generic EQ-5D and the cancer-specific Functional Assessment of Cancer Therapy-General (FACT-G). METHODS: Patients with advanced cancer of the bladder, brain, breast, colon/rectum, head/neck, hepatobiliary tract/pancreas, kidney, lung, lymphoma, ovary, or prostate completed the EQ-5D and FACT-G...
April 2016: Clinical Therapeutics
Amanda Wurz, Jennifer Brunet
BACKGROUND: The benefits of physical activity for child and adult cancer survivors have been summarized in previous systematic reviews. However, no review has summarized the evidence for adolescent cancer survivors. OBJECTIVE: This paper describes the design of a protocol to conduct a systematic review of published studies examining the effects of physical activity on health and quality of life outcomes for adolescent cancer survivors. METHODS: Several guidelines informed the development of this protocol...
2016: JMIR Research Protocols
Lauren C Capozzi, Margaret L McNeely, Harold Y Lau, Raylene A Reimer, Janine Giese-Davis, Tak S Fung, S Nicole Culos-Reed
BACKGROUND: Patients with head and neck cancer experience loss of weight and muscle mass, decreased functioning, malnutrition, depression, and declines in quality of life during and after treatment. The purpose of this exploratory randomized study was to determine the optimal timing for the initiation of a lifestyle and progressive resistance exercise training intervention (during or after radiation therapy), as determined by intervention adherence and by comparing between-group outcomes across 24 weeks...
April 15, 2016: Cancer
Kirsten A Nyrop, Leigh F Callahan, Christine Rini, Mary Altpeter, Betsy Hackney, Amy DePue, Anne Wilson, Arielle Schechter, Hyman B Muss
PURPOSE: Breast cancer survivors on aromatase inhibitors (AI) often experience side effects of joint pain, stiffness, or achiness (arthralgia). This study presents findings from a qualitative study of survivors on an AI regarding their knowledge of potential joint pain side effects and how both AI side effects and their management through moderate physical activity could be discussed during routine visits with their oncology provider. METHODS: Qualitative data from semi-structured interviews were content analyzed for emergent themes...
June 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Thomas C Whisenant, Eigen R Peralta, Lauren D Aarreberg, Nina J Gao, Steven R Head, Phillip Ordoukhanian, Jamie R Williamson, Daniel R Salomon
Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the importance of post-transcriptional regulation by RNA-binding proteins (RBPs) has not been considered in depth. We describe a new model expanding and activating primary human CD4 T cells and applied this to characterizing activation-induced assembly of splicing factors centered on U2AF2...
2015: PloS One
N Ouattassi, N Benmansour, S ElFakir, C Nejjari, M N Alami
Disease-specific quality of life (QOL) measures have enhanced the capacity of outcome measures to evaluate subtle changes and differences between groups. As many of the QOL measures have been developed in English, they require translation to ensure their usefulness in a multi-cultural and/or international society. Published guidelines provide formal methods to achieve cross-culturally comparable versions of a QOL tool. The aim of this study was to adapt the head and neck specific module of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-H&N 35 questionnaire) into Moroccan Arabic and to determine its psychometric properties...
September 2016: European Archives of Oto-rhino-laryngology
Ylva Tiblom Ehrsson, Kay Sundberg, Göran Laurell, Ann Langius-Eklöf
AIM: To explore individual quality of life in patients with head and neck cancer from diagnosis up to 3 months after termination of radiotherapy. RESEARCH QUESTIONS: 1) Which areas in life are important to quality of life, and which are influenced by the disease and by having oral or enteral nutrition; and 2) Which areas in life are influenced by having a nasogastric feeding tube (NGT) or a percutaneous endoscopic gastrostomy (PEG) tube? MATERIAL AND METHODS: Data were collected in 36 patients...
2015: Upsala Journal of Medical Sciences
Shuang G Zhao, Neil B Alexander, Zora Djuric, Jessica Zhou, Yebin Tao, Matthew Schipper, Felix Y Feng, Avraham Eisbruch, Francis P Worden, Scott J Strath, Shruti Jolly
BACKGROUND: Concurrent chemoradiotherapy (concurrent CRT) to treat head and neck cancer is associated with significant reductions of weight, mobility, and quality of life (QOL). An intervention focusing on functional exercise may attenuate these losses. METHODS: We allocated patients to a 14-week functional resistance and walking program designed to maintain physical activity during cancer treatment (MPACT group; n = 11), or to usual care (control group; n = 9)...
April 2016: Head & Neck
K Kelly Gallagher, Assuntina G Sacco, Julia Shin-Jung Lee, Rodney Taylor, Eric J P Chanowski, Carol R Bradford, Mark E Prince, Jeffrey S Moyer, Gregory T Wolf, Francis P Worden, Avraham Eisbruch, Douglas B Chepeha
IMPORTANCE: This study describes the effect of adjuvant treatment on shoulder-related quality of life, leisure activities, and employment for patients undergoing neck dissection for head and neck cancer. OBJECTIVE: To explore the association between treatment outcome and shoulder-related on critical daily life functions such as employment and recreation. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional study of patients with head and neck cancer at a tertiary care hospital...
October 2015: JAMA Otolaryngology—Head & Neck Surgery
K Aro, L Bäck, V Loimu, K Saarilahti, S Rogers, H Sintonen, R Roine, Antti Mäkitie
Management of head and neck cancer influences both physical and mental wellbeing. Measuring the health-related quality of life (HRQoL) is important, as various treatment modalities are associated with significant morbidity and mortality. In this prospective cohort study, we tested the feasibility of the generic 15D HRQoL instrument in 214 head and neck cancer patients managed with surgery, definitive (chemo)radiotherapy, or with combined modality treatment. HRQoL was assessed at baseline and three times after treatment onset during 1 year, and compared with that of general population standardized for age and sex...
August 2016: European Archives of Oto-rhino-laryngology
L Sammut, L R Fraser, M J Ward, T Singh, N N Patel
BACKGROUND: Head and neck cancer (HNC), and its treatment, is associated with significant side-effects which can affect quality of life (QOL). Physical activity (PA) is known to improve a number of QOL measures. We aimed to determine the prevalence of PA pre- and post-treatment of HNC and to determine associations with QOL. METHODS: A questionnaire-based survey of 172 patients pre- and post-treatment for HNC. RESULTS: A total of 62.2% of patients met current UK PA guidelines pre-treatment, reducing to 40...
June 2016: Clinical Otolaryngology
Namrata Vijayvergia, Crystal S Denlinger
Advances in early detection and curative therapies have led to an increased number of cancer survivors over the last twenty years. With this population comes the need to evaluate the late and long term effects of cancer treatment and develop recommendations about how to optimally care for these survivors. Lifestyle factors (diet, body weight, physical activity, and smoking) have been linked to a higher risk of many medical comorbidities (cardiovascular, metabolic, etc.). There is increasing evidence linking these factors to the risk of developing cancer and likely cancer-related outcomes...
2015: Journal of Personalized Medicine
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