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https://www.readbyqxmd.com/read/28258889/geriatric-assessment-as-a-predictor-of-tolerance-quality-of-life-and-outcomes-in-older-patients-with-head-and-neck-cancers-and-lung-cancers-receiving-radiation-therapy
#1
Noam A VanderWalde, Allison M Deal, Elizabeth Comitz, Lori Stravers, Hyman Muss, Bryce B Reeve, Ethan Basch, Joel Tepper, Bhishamjit Chera
PURPOSE: To evaluate the association between functional status based on a geriatric assessment (GA) and outcomes of tolerance to treatment in patients with lung or head and neck cancer receiving radiation therapy (RT) or chemoradiation (CRT). METHODS AND MATERIALS: A prospective cohort study was conducted in patients aged ≥65 years with head and neck cancer or lung cancer undergoing curative intent RT or CRT. Pretreatment GA, health-related quality of life (HRQoL), and patient-reported outcomes (PRO) were obtained...
December 2, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28247128/the-self-care-practices-of-family-caregivers-of-persons-with-poor-prognosis-cancer-differences-by-varying-levels-of-caregiver-well-being-and-preparedness
#2
J Nicholas Dionne-Odom, Wendy Demark-Wahnefried, Richard A Taylor, Gabrielle B Rocque, Andres Azuero, Aras Acemgil, Michelle Y Martin, Meka Astin, Deborah Ejem, Elizabeth Kvale, Karen Heaton, Maria Pisu, Edward E Partridge, Marie A Bakitas
PURPOSE: Little is known about the impact of family caregiving for adults with poor prognosis cancer on caregivers' own individual self-care practices. We explored differences in caregivers' discrete self-care practices associated with varying levels of caregiver well-being, preparedness, and decision-making self-efficacy. METHODS: Cross-sectional survey within eight community-based southeastern U.S. cancer centers was conducted. Family caregivers of Medicare beneficiaries ≥65 years with pancreatic, lung, brain, ovarian, head and neck, hematologic, or stage IV cancer completed measures of individual self-care practices (health responsibility, physical activity, nutrition, spiritual growth, interpersonal relations, stress management, and sleep), well-being (anxiety, depression, and health-related quality of life [HRQoL]), preparedness, and decision-making self-efficacy...
March 1, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28204992/the-life-experience-of-nutrition-impact-symptoms-during-treatment-for-head-and-neck-cancer-patients-a-systematic-review-and-meta-synthesis
#3
REVIEW
Valentina Bressan, Annamaria Bagnasco, Giuseppe Aleo, Gianluca Catania, Milko P Zanini, Fiona Timmins, Loredana Sasso
PURPOSE: In the literature, there is limited research about the changed meaning of food, the eating and the eating experience during treatment in patients with head and neck cancer. This systematic review includes findings from a qualitative research synthesis to gain a deeper understanding of the influence and experiences of dysphagia, dysgeusia, oral mucositis and xerostomia in head and neck cancer patients (HNC) and suggests recommendations for care practice. METHOD: A systematic review and meta-synthesis techniques were adopted to identify, appraise and synthesize the relevant literature regarding the experience of nutritional symptoms of HNC patients conducted according to the PRISMA guidelines...
February 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28156569/differences-in-self-care-behaviors-by-varying-levels-of-caregiving-intensity-performance-and-well-being-among-family-caregivers-of-patients-with-high-mortality-cancer
#4
Wendy Demark-Wahnefried, Richard A Taylor, Gabrielle Betty Rocque, Andres Azuero, Aras Acemgil, Michelle Y Martin, Meka Astin, Deborah Ejem, Elizabeth Ann Kvale, Karen Heaton, Maria Pisu, Edward E Partridge, Marie Bakitas
239 Background: Family caregivers of high-mortality cancer patients perform vital tasks that deter from their own self-care. We aimed to determine differences in self-care behaviors by varying levels of caregiving intensity, well-being, and performance. METHODS: Cross-sectional survey conducted in community settings of 8 cancer centers in AL, FL, and TN. Two-hundred and ninety-four family caregivers of Medicare beneficiaries diagnosed with pancreatic, lung, brain, ovarian, head & neck, hematologic, or stage IV cancer completed measures of self-care behaviors, including health responsibility, physical activity, nutrition, spiritual growth, interpersonal relations, stress management, and sleep; anxiety and depression; health-related quality of life (HRQoL); caregiver competence and preparedness; and decision-making self-efficacy...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28155041/informational-needs-of-head-and-neck-cancer-patients
#5
Janet Papadakos, Maurene McQuestion, Anandita Gokhale, Ali Damji, Aileen Trang, Nazek Abdelmutti, Jolie Ringash
The patient journey with head and neck cancer (HNC) is particularly challenging given the physical and functional impact of the cancer and treatment. The ability to perform activities of daily living can be severely compromised and have a profound impact on psychosocial well-being. These complex and long-lasting effects can affect patient quality of life for months to years and the literature shows that information for HNC patients is often insufficient. This observational cross-sectional study utilized survey methodology to investigate the informational needs of HNC patients and the preferred modalities for delivery...
February 2, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28152942/communities-of-practice-a-jurisdictional-approach-to-improving-the-quality-of-care-in-radiation-medicine-in-ontario
#6
Michelle Ang, Lindsay Elizabeth Reddeman, Michael Sharpe, Margaret Hart, Carina Simniceanu, Stephen Breen, Joon-Hyung J Kim, Dani Scott, Khaled Zaza, David D'Souza, Michael F Milosevic, Stewart Gaede, Andrea Marshall, Brian P Yaremko, Katharina Sixel, Nicole Harnett, Eric Gutierrez, Padraig Richard Warde
122 Background: The Radiation Treatment Program (RTP) at Cancer Care Ontario (CCO) established several Communities of Practice (CoPs), with the goal of improving radiation treatment (RT) quality and safety. The RTP identifies variation in practice and quality improvement (QI) opportunities in the 14 Regional Cancer Centres (RCCs) and facilitates the development of CoPs to share best practices and standardize care. METHODS: Since 2010, the RTP has formed 7 CoPs ( > 185 members in total): 4 intra-disciplinary (Radiation Therapy, Medical Physics, Advanced Practice Radiation Therapy, Radiation Safety) and 3 inter-disciplinary (Head and Neck (HN), Gynecological (GYNE) and Lung Cancer)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28047744/we-a-201-01-memorial-introduction
#7
C Marshall
Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047091/we-a-201-02-modern-statistical-modeling
#8
A Niemierko
Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046695/mo-de-bra-03-the-ottawa-medical-physics-institute-ompi-a-practical-model-for-academic-program-collaboration-in-a-multi-centre-city
#9
M McEwen, D Rogers, P Johns/Sup
PURPOSE: To build a world-class medical physics educational program that capitalizes on expertise distributed over several clinical, government, and academic centres. Few if any of these centres would have the critical mass to solely resource a program. METHODS: In order to enable an academic program, stakeholders from five institutions made a proposal to Carleton University for a) a research network with defined membership requirements and a process for accepting new members, and b) a graduate specialization (MSc and PhD) in medical physics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046561/we-a-201-00-anne-and-donald-herbert-distinguished-lectureship-on-modern-statistical-modeling
#10
Joseph Deasy
Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041841/actl6a-is-co-amplified-with-p63-in-squamous-cell-carcinoma-to-drive-yap-activation-regenerative-proliferation-and-poor-prognosis
#11
Srinivas Vinod Saladi, Kenneth Ross, Mihriban Karaayvaz, Purushothama R Tata, Hongmei Mou, Jayaraj Rajagopal, Sridhar Ramaswamy, Leif W Ellisen
Loss-of-function mutations in SWI/SNF chromatin-remodeling subunit genes are observed in many cancers, but an oncogenic role for SWI/SNF is not well established. Here, we reveal that ACTL6A, encoding an SWI/SNF subunit linked to stem cell and progenitor cell function, is frequently co-amplified and highly expressed together with the p53 family member p63 in head and neck squamous cell carcinoma (HNSCC). ACTL6A and p63 physically interact, cooperatively controlling a transcriptional program that promotes proliferation and suppresses differentiation, in part through activation of the Hippo-YAP pathway via regulators including WWC1...
January 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28024725/adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-recommendations-and-head-and-neck-cancers-risk
#12
Francesca Bravi, Jerry Polesel, Werner Garavello, Diego Serraino, Eva Negri, Gianni Franchin, Carlo La Vecchia, Cristina Bosetti
OBJECTIVES: The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk. MATERIALS AND METHODS: We obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28004448/social-networks-social-support-and-social-negativity-a-qualitative-study-of-head-and-neck-cancer-caregivers-experiences
#13
M Balfe, K Keohane, K O'Brien, L Sharp
Head and neck cancer is a serious form of cancer that can generate substantial physical and psychosocial morbidity. Informal caregivers can help patients to manage head and neck cancer and its emotional impacts, both during and after treatment. Caregivers, however, can experience considerable stress as a result of their caring activities. Supportive relationships can protect caregivers from psychosocial strain. Thirty-one head and neck cancer caregivers were interviewed about their experiences of accessing social support from their social networks; difficulties that they experienced accessing this support; and strategies that they used to address these difficulties...
December 22, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27803571/initial-experience-of-head-and-neck-cancer-patients-treated-in-an-oncologist-led-palliative-cancer-care-clinic-at-a-tertiary-cancer-care-center-in-uttar-pradesh-is-the-initiative-of-a-full-fledged-palliative-care-for-cancer-patients-justified
#14
Punita Lal, Mranalini Verma, Gaurav Kumar, Resham Shrivastava, Shaleen Kumar
INTRODUCTION: Poor socioeconomic status and illiteracy attribute to the advanced presentation of head and neck cancer (HNC) patients in India and are candidates for palliation in our setup. We set up a palliative cancer care clinic (PCCC), and an audit of initial 153 HNC patients is presented. AIMS AND OBJECTIVES: To assess the impact of palliative cancer care services. METHODOLOGY: Data of advanced HNC patients suited for palliation were collected to document demography, symptomatology, cancer treatment, and supportive care...
October 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27716204/insulin-growth-factor-1-like-receptor-igf-1r
#15
Gopal Iyer, James Price, Shay Bourgeois, Eric Armstrong, Shyhmin Huang, Paul M Harari
BACKGROUND: The epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and several other human cancers. Monoclonal antibodies, such as cetuximab that block EGFR signaling, have emerged as valuable molecular targeting agents in clinical cancer therapy. Prolonged exposure to cetuximab can result in cells acquiring resistance by a process that remains incompletely understood. METHODS: In this study, we analyzed the immediate early molecular response of cetuximab on physical interactions between EGFR and Insulin growth factor 1 like receptor (IGF-1R) in head and neck cancer cells that are resistant to cetuximab...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27269579/unmet-needs-and-relationship-challenges-of-head-and-neck-cancer-patients-and-their-spouses
#16
Hoda Badr, Krista Herbert, Batya Reckson, Hope Rainey, Aminah Sallam, Vishal Gupta
In head and neck cancer (HNC), couple-based interventions may be useful for facilitating treatment completion, patient rehabilitation, and improving both partners' quality of life. With the goal of identifying targets for future interventions, we conducted a qualitative study to understand patient and spouse unmet needs and relationship challenges during curative radiotherapy for HNC. Semistructured interviews were conducted with six HNC patients (83% male) and six spouses (83% female) within 6 months of completing treatment...
July 2016: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/27235556/biocompatible-zr-based-nanoscale-mofs-coated-with-modified-poly-%C3%AE%C2%B5-caprolactone-as-anticancer-drug-carriers
#17
Maria Filippousi, Stuart Turner, Karen Leus, Panoraia I Siafaka, Eirini D Tseligka, Matthias Vandichel, Stavroula G Nanaki, Ioannis S Vizirianakis, Dimitrios N Bikiaris, Pascal Van Der Voort, Gustaaf Van Tendeloo
Nanoscale Zr-based metal organic frameworks (MOFs) UiO-66 and UiO-67 were studied as potential anticancer drug delivery vehicles. Two model drugs were used, hydrophobic paclitaxel and hydrophilic cisplatin, and were adsorbed onto/into the nano MOFs (NMOFs). The drug loaded MOFs were further encapsulated inside a modified poly(ε-caprolactone) with d-α-tocopheryl polyethylene glycol succinate polymeric matrix, in the form of microparticles, in order to prepare sustained release formulations and to reduce the drug toxicity...
July 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27221843/parental-experiences-with-chemotherapy-induced-alopecia-among-childhood-cancer-patients-in-indonesia
#18
Stefanus Gunawan, Chloe Ten Broeke, Peter van de Ven, Marijn Arnoldussen, Gertjan Kaspers, Saskia Mostert
BACKGROUND: This study assessed parental experiences with chemotherapy-induced alopecia among children with cancer treated at an Indonesian academic hospital. MATERIALS AND METHODS: Fifty parents of childhood cancer patients were interviewed using semi-structured questionnaires. RESULTS: The moment that hair fell out was the moment that parents (84%) had to admit their child had cancer. Alopecia was a traumatizing painful experience (46%)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27183032/association-of-leisure-time-physical-activity-with-risk-of-26-types-of-cancer-in-1-44-million-adults
#19
Steven C Moore, I-Min Lee, Elisabete Weiderpass, Peter T Campbell, Joshua N Sampson, Cari M Kitahara, Sarah K Keadle, Hannah Arem, Amy Berrington de Gonzalez, Patricia Hartge, Hans-Olov Adami, Cindy K Blair, Kristin B Borch, Eric Boyd, David P Check, Agnès Fournier, Neal D Freedman, Marc Gunter, Mattias Johannson, Kay-Tee Khaw, Martha S Linet, Nicola Orsini, Yikyung Park, Elio Riboli, Kim Robien, Catherine Schairer, Howard Sesso, Michael Spriggs, Roy Van Dusen, Alicja Wolk, Charles E Matthews, Alpa V Patel
IMPORTANCE: Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE: To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking. DESIGN, SETTING, AND PARTICIPANTS: We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004)...
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27149571/comparison-of-patient-and-practitioner-reported-toxic-effects-associated-with-chemoradiotherapy-for-head-and-neck-cancer
#20
Aaron D Falchook, Rebecca Green, Mary E Knowles, Robert J Amdur, William Mendenhall, David N Hayes, Juneko E Grilley-Olson, Jared Weiss, Bryce B Reeve, Sandra A Mitchell, Ethan M Basch, Bhishamjit S Chera
IMPORTANCE: Agreement between patient- and practitioner-reported toxic effects during chemoradiotherapy for head and neck cancer is unknown. OBJECTIVE: To compare patient-reported symptom severity and practitioner-reported toxic effects among patients receiving chemoradiotherapy for head and neck cancer. DESIGN, SETTING, AND PARTICIPANTS: Forty-four patients participating in a phase 2 trial of deintensified chemoradiotherapy for oropharyngeal carcinoma were included in the present study (conducted from February 8, 2012, to March 2, 2015)...
June 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
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