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https://www.readbyqxmd.com/read/28047744/we-a-201-01-memorial-introduction
#1
C Marshall
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047091/we-a-201-02-modern-statistical-modeling
#2
A Niemierko
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046695/mo-de-bra-03-the-ottawa-medical-physics-institute-ompi-a-practical-model-for-academic-program-collaboration-in-a-multi-centre-city
#3
M McEwen, D Rogers, P Johns/Sup
PURPOSE: To build a world-class medical physics educational program that capitalizes on expertise distributed over several clinical, government, and academic centres. Few if any of these centres would have the critical mass to solely resource a program. METHODS: In order to enable an academic program, stakeholders from five institutions made a proposal to Carleton University for a) a research network with defined membership requirements and a process for accepting new members, and b) a graduate specialization (MSc and PhD) in medical physics...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046561/we-a-201-00-anne-and-donald-herbert-distinguished-lectureship-on-modern-statistical-modeling
#4
Joseph Deasy
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041841/actl6a-is-co-amplified-with-p63-in-squamous-cell-carcinoma-to-drive-yap-activation-regenerative-proliferation-and-poor-prognosis
#5
Srinivas Vinod Saladi, Kenneth Ross, Mihriban Karaayvaz, Purushothama R Tata, Hongmei Mou, Jayaraj Rajagopal, Sridhar Ramaswamy, Leif W Ellisen
Loss-of-function mutations in SWI/SNF chromatin-remodeling subunit genes are observed in many cancers, but an oncogenic role for SWI/SNF is not well established. Here, we reveal that ACTL6A, encoding an SWI/SNF subunit linked to stem cell and progenitor cell function, is frequently co-amplified and highly expressed together with the p53 family member p63 in head and neck squamous cell carcinoma (HNSCC). ACTL6A and p63 physically interact, cooperatively controlling a transcriptional program that promotes proliferation and suppresses differentiation, in part through activation of the Hippo-YAP pathway via regulators including WWC1...
January 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28024725/adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-recommendations-and-head-and-neck-cancers-risk
#6
Francesca Bravi, Jerry Polesel, Werner Garavello, Diego Serraino, Eva Negri, Gianni Franchin, Carlo La Vecchia, Cristina Bosetti
OBJECTIVES: The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk. MATERIALS AND METHODS: We obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28004448/social-networks-social-support-and-social-negativity-a-qualitative-study-of-head-and-neck-cancer-caregivers-experiences
#7
M Balfe, K Keohane, K O'Brien, L Sharp
Head and neck cancer is a serious form of cancer that can generate substantial physical and psychosocial morbidity. Informal caregivers can help patients to manage head and neck cancer and its emotional impacts, both during and after treatment. Caregivers, however, can experience considerable stress as a result of their caring activities. Supportive relationships can protect caregivers from psychosocial strain. Thirty-one head and neck cancer caregivers were interviewed about their experiences of accessing social support from their social networks; difficulties that they experienced accessing this support; and strategies that they used to address these difficulties...
December 22, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27803571/initial-experience-of-head-and-neck-cancer-patients-treated-in-an-oncologist-led-palliative-cancer-care-clinic-at-a-tertiary-cancer-care-center-in-uttar-pradesh-is-the-initiative-of-a-full-fledged-palliative-care-for-cancer-patients-justified
#8
Punita Lal, Mranalini Verma, Gaurav Kumar, Resham Shrivastava, Shaleen Kumar
INTRODUCTION: Poor socioeconomic status and illiteracy attribute to the advanced presentation of head and neck cancer (HNC) patients in India and are candidates for palliation in our setup. We set up a palliative cancer care clinic (PCCC), and an audit of initial 153 HNC patients is presented. AIMS AND OBJECTIVES: To assess the impact of palliative cancer care services. METHODOLOGY: Data of advanced HNC patients suited for palliation were collected to document demography, symptomatology, cancer treatment, and supportive care...
October 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27716204/insulin-growth-factor-1-like-receptor-igf-1r
#9
Gopal Iyer, James Price, Shay Bourgeois, Eric Armstrong, Shyhmin Huang, Paul M Harari
BACKGROUND: The epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and several other human cancers. Monoclonal antibodies, such as cetuximab that block EGFR signaling, have emerged as valuable molecular targeting agents in clinical cancer therapy. Prolonged exposure to cetuximab can result in cells acquiring resistance by a process that remains incompletely understood. METHODS: In this study, we analyzed the immediate early molecular response of cetuximab on physical interactions between EGFR and Insulin growth factor 1 like receptor (IGF-1R) in head and neck cancer cells that are resistant to cetuximab...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27269579/unmet-needs-and-relationship-challenges-of-head-and-neck-cancer-patients-and-their-spouses
#10
Hoda Badr, Krista Herbert, Batya Reckson, Hope Rainey, Aminah Sallam, Vishal Gupta
In head and neck cancer (HNC), couple-based interventions may be useful for facilitating treatment completion, patient rehabilitation, and improving both partners' quality of life. With the goal of identifying targets for future interventions, we conducted a qualitative study to understand patient and spouse unmet needs and relationship challenges during curative radiotherapy for HNC. Semistructured interviews were conducted with six HNC patients (83% male) and six spouses (83% female) within 6 months of completing treatment...
July 2016: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/27235556/biocompatible-zr-based-nanoscale-mofs-coated-with-modified-poly-%C3%AE%C2%B5-caprolactone-as-anticancer-drug-carriers
#11
Maria Filippousi, Stuart Turner, Karen Leus, Panoraia I Siafaka, Eirini D Tseligka, Matthias Vandichel, Stavroula G Nanaki, Ioannis S Vizirianakis, Dimitrios N Bikiaris, Pascal Van Der Voort, Gustaaf Van Tendeloo
Nanoscale Zr-based metal organic frameworks (MOFs) UiO-66 and UiO-67 were studied as potential anticancer drug delivery vehicles. Two model drugs were used, hydrophobic paclitaxel and hydrophilic cisplatin, and were adsorbed onto/into the nano MOFs (NMOFs). The drug loaded MOFs were further encapsulated inside a modified poly(ε-caprolactone) with d-α-tocopheryl polyethylene glycol succinate polymeric matrix, in the form of microparticles, in order to prepare sustained release formulations and to reduce the drug toxicity...
July 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27221843/parental-experiences-with-chemotherapy-induced-alopecia-among-childhood-cancer-patients-in-indonesia
#12
Stefanus Gunawan, Chloe Ten Broeke, Peter van de Ven, Marijn Arnoldussen, Gertjan Kaspers, Saskia Mostert
BACKGROUND: This study assessed parental experiences with chemotherapy-induced alopecia among children with cancer treated at an Indonesian academic hospital. MATERIALS AND METHODS: Fifty parents of childhood cancer patients were interviewed using semi-structured questionnaires. RESULTS: The moment that hair fell out was the moment that parents (84%) had to admit their child had cancer. Alopecia was a traumatizing painful experience (46%)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27183032/association-of-leisure-time-physical-activity-with-risk-of-26-types-of-cancer-in-1-44-million-adults
#13
Steven C Moore, I-Min Lee, Elisabete Weiderpass, Peter T Campbell, Joshua N Sampson, Cari M Kitahara, Sarah K Keadle, Hannah Arem, Amy Berrington de Gonzalez, Patricia Hartge, Hans-Olov Adami, Cindy K Blair, Kristin B Borch, Eric Boyd, David P Check, Agnès Fournier, Neal D Freedman, Marc Gunter, Mattias Johannson, Kay-Tee Khaw, Martha S Linet, Nicola Orsini, Yikyung Park, Elio Riboli, Kim Robien, Catherine Schairer, Howard Sesso, Michael Spriggs, Roy Van Dusen, Alicja Wolk, Charles E Matthews, Alpa V Patel
IMPORTANCE: Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE: To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking. DESIGN, SETTING, AND PARTICIPANTS: We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004)...
June 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27149571/comparison-of-patient-and-practitioner-reported-toxic-effects-associated-with-chemoradiotherapy-for-head-and-neck-cancer
#14
Aaron D Falchook, Rebecca Green, Mary E Knowles, Robert J Amdur, William Mendenhall, David N Hayes, Juneko E Grilley-Olson, Jared Weiss, Bryce B Reeve, Sandra A Mitchell, Ethan M Basch, Bhishamjit S Chera
IMPORTANCE: Agreement between patient- and practitioner-reported toxic effects during chemoradiotherapy for head and neck cancer is unknown. OBJECTIVE: To compare patient-reported symptom severity and practitioner-reported toxic effects among patients receiving chemoradiotherapy for head and neck cancer. DESIGN, SETTING, AND PARTICIPANTS: Forty-four patients participating in a phase 2 trial of deintensified chemoradiotherapy for oropharyngeal carcinoma were included in the present study (conducted from February 8, 2012, to March 2, 2015)...
June 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27133907/quality-of-life-impairment-in-patients-with-head-and-neck-cancer-and-their-caregivers-a-comparative-study
#15
Laís Rigoni, Raphaella Falco Bruhn, Rafael De Cicco, Jossi Ledo Kanda, Leandro Luongo Matos
INTRODUCTION: Head and neck cancer represents 3% of all the types of malignant neoplasms and squamous cell carcinoma (SCC) is responsible for 90% of these cases. There have been some studies evaluating the quality of life of these patients, but little is known about the physical and emotional effects on their caregivers. OBJECTIVE: To evaluate the quality of life of patients with head and neck cancer and their caregivers by applying validated questionnaires. METHODS: Thirty patients with advanced tumors (SCC stage III or IV) and their 30 caregivers were included...
November 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27071807/does-therapeutic-writing-help-people-with-long-term-conditions-systematic-review-realist-synthesis-and-economic-considerations
#16
REVIEW
Olga P Nyssen, Stephanie J C Taylor, Geoff Wong, Elizabeth Steed, Liam Bourke, Joanne Lord, Carol A Ross, Sheila Hayman, Victoria Field, Ailish Higgins, Trisha Greenhalgh, Catherine Meads
BACKGROUND: Writing therapy to improve physical or mental health can take many forms. The most researched model of therapeutic writing (TW) is unfacilitated, individual expressive writing (written emotional disclosure). Facilitated writing activities are less widely researched. DATA SOURCES: Databases, including MEDLINE, EMBASE, PsycINFO, Linguistics and Language Behaviour Abstracts, Allied and Complementary Medicine Database and Cumulative Index to Nursing and Allied Health Literature, were searched from inception to March 2013 (updated January 2015)...
April 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27041407/using-patient-reported-outcomes-to-compare-relative-burden-of-cancer-eq-5d-and-functional-assessment-of-cancer-therapy-general-in-eleven-types-of-cancer
#17
A Simon Pickard, Ruixuan Jiang, Hsiang-Wen Lin, Sarah Rosenbloom, David Cella
PURPOSE: The objective of this study was to compare the health-related quality of life (HRQL) burden across different types of advanced cancer with the use of 2 widely used patient-reported outcome measures, the generic EQ-5D and the cancer-specific Functional Assessment of Cancer Therapy-General (FACT-G). METHODS: Patients with advanced cancer of the bladder, brain, breast, colon/rectum, head/neck, hepatobiliary tract/pancreas, kidney, lung, lymphoma, ovary, or prostate completed the EQ-5D and FACT-G...
April 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27030210/a-systematic-review-protocol-to-assess-the-effects-of-physical-activity-on-health-and-quality-of-life-outcomes-in-adolescent-cancer-survivors
#18
Amanda Wurz, Jennifer Brunet
BACKGROUND: The benefits of physical activity for child and adult cancer survivors have been summarized in previous systematic reviews. However, no review has summarized the evidence for adolescent cancer survivors. OBJECTIVE: This paper describes the design of a protocol to conduct a systematic review of published studies examining the effects of physical activity on health and quality of life outcomes for adolescent cancer survivors. METHODS: Several guidelines informed the development of this protocol...
2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/26828426/patient-reported-outcomes-body-composition-and-nutrition-status-in-patients-with-head-and-neck-cancer-results-from-an-exploratory-randomized-controlled-exercise-trial
#19
RANDOMIZED CONTROLLED TRIAL
Lauren C Capozzi, Margaret L McNeely, Harold Y Lau, Raylene A Reimer, Janine Giese-Davis, Tak S Fung, S Nicole Culos-Reed
BACKGROUND: Patients with head and neck cancer experience loss of weight and muscle mass, decreased functioning, malnutrition, depression, and declines in quality of life during and after treatment. The purpose of this exploratory randomized study was to determine the optimal timing for the initiation of a lifestyle and progressive resistance exercise training intervention (during or after radiation therapy), as determined by intervention adherence and by comparing between-group outcomes across 24 weeks...
April 15, 2016: Cancer
https://www.readbyqxmd.com/read/26757739/aromatase-inhibitor-associated-arthralgia-the-importance-of-oncology-provider-patient-communication-about-side-effects-and-potential-management-through-physical-activity
#20
Kirsten A Nyrop, Leigh F Callahan, Christine Rini, Mary Altpeter, Betsy Hackney, Amy DePue, Anne Wilson, Arielle Schechter, Hyman B Muss
PURPOSE: Breast cancer survivors on aromatase inhibitors (AI) often experience side effects of joint pain, stiffness, or achiness (arthralgia). This study presents findings from a qualitative study of survivors on an AI regarding their knowledge of potential joint pain side effects and how both AI side effects and their management through moderate physical activity could be discussed during routine visits with their oncology provider. METHODS: Qualitative data from semi-structured interviews were content analyzed for emergent themes...
June 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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