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https://www.readbyqxmd.com/read/29155961/disease-activity-decrease-is-associated-with-improvement-in-work-productivity-over-1-year-in-early-axial-spondyloarthritis-spondyloarthritis-caught-early-cohort
#1
Miranda van Lunteren, Zineb Ez-Zaitouni, Camilla Fongen, Robert Landewé, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen
Objectives: To assess if a change in disease activity is associated with a change in work productivity loss (WPL) over 1 year in early axial SpA (axSpA) patients. Methods: Baseline and 1 year data of axSpA patients in the SPondyloArthritis Caught Early cohort were analysed. Linear regression models were built explaining the change in the Ankylosing Spondylitis Disease Activity Score (ASDAS) over time by the change in absenteeism, presenteeism, WPL and activity impairment over time...
October 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29148411/vitamin-d-status-in-spondyloarthritis-results-of-the-asas-comospa-international-study
#2
Sílvia Fernandes, Adrien Etcheto, Désirée van der Heijde, Robert Landewé, Filip van den Bosch, Maxime Dougados, Anna Moltó
OBJECTIVES: Spondyloarthritis (SpA) encompasses both bone production and bone loss, and the latter is particularly linked to inflammation. Vitamin D deficiency has been associated with several inflammatory conditions (i.e. cardiovascular disease, rheumatoid arthritis), but it has been poorly evaluated in SpA patients. We aimed to a) describe the prevalence of vitamin D deficiency in SpA patients worldwide; b) compare SpA patients with and without vitamin D deficiency in terms of disease phenotype, activity severity and comorbidities...
November 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29142035/the-sex-influence-on-response-to-tumor-necrosis-factor-%C3%AE-inhibitors-and-remission-in-axial-spondyloarthritis
#3
Ennio Lubrano, Fabio Massimo Perrotta, Maria Manara, Salvatore D'Angelo, Olga Addimanda, Roberta Ramonda, Leonardo Punzi, Ignazio Olivieri, Carlo Salvarani, Antonio Marchesoni
OBJECTIVE: The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA). METHODS: In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29119479/utility-of-ct-imaging-in-differentiating-sacroiliitis-associated-with-spondyloarthritis-from-gouty-sacroiliitis-a-retrospective-study
#4
Jyoti Panwar, Pulukool Sandhya, Madhavi Kandagaddala, Aswin Nair, Visalakshi Jeyaseelan, Debashish Danda
Sacroiliitis is one of the criteria for classification as spondyloarthritis (SpA), though not unique to SpA. Other conditions including gout may be erroneously diagnosed as SpA due to sacroiliitis. The objective was to identify specific CT findings in sacroiliitis associated with SpA and gout. In this retrospective study, CT images of patients with sacroiliitis and clinical diagnosis of gout or SpA from 2010 to 2015 were independently reviewed by two radiologists, blinded to diagnosis. Axial and coronal oblique images were analyzed for characteristics of erosions...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29099615/interrater-reliability-and-radiation-dosage-of-oblique-coronal-computed-tomography-for-sacroiliitis-in-comparison-with-axial-computed-tomography
#5
Sheng-Guang Li, Xiangyuan Liu, Huiqiong Zhou, Qing Zhang
OBJECTIVE: Sacroiliitis, a prerequisite to the diagnosis of ankylosing spondylitis, can be ascertained by CT when MRI is not available. Oblique coronal CT is an increasingly popular approach when examining sacroiliitis. The goal of this study was to understand how oblique coronal CT compared with axial CT scanning in terms of raters' concordance when diagnosing sacroiliitis. METHODS: 52 subjects < 45 years of age at onset of their chronic lower back pain were sequentially scanned by X-ray, axial CT and oblique coronal CT...
November 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29093157/sacroiliac-joint-magnetic-resonance-imaging-in-asymptomatic-patients-with-recurrent-acute-anterior-uveitis-a-proof-of-concept-study
#6
Thauana L Oliveira, Walter P Maksymowych, Robert G W Lambert, Cristina Muccioli, Artur R C Fernandes, Marcelo M Pinheiro
OBJECTIVE: Our aim was to quantify bone marrow edema (BME) and/or structural lesions in the sacroiliac joints (SIJ) of patients with recurrent acute anterior uveitis (rAAU) with or without back pain, to evaluate the frequency of axial (axSpA) and peripheral spondyloarthritis (pSpA) and to establish which criterion for magnetic resonance imaging (MRI) positivity best reflected the global assessment of SIJ MRI. METHODS: A total of 50 patients with rAAU without prior rheumatologic diagnosis were included in our cross-sectional study, and these patients were compared to 21 healthy volunteers...
November 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29089045/a-young-female-presenting-with-unilateral-sacroiliitis-following-dengue-virus-infection-a-case-report
#7
W D Jayamali, H M M T B Herath, Aruna Kulatunga
BACKGROUND: Dengue is a common arthropod-borne viral infection in Sri Lanka which is spread by the mosquitos of the genus Aedes. The clinical features of dengue include high-grade fever associated with arthralgia and myalgia. However, dengue virus is not considered an arthritogenic virus. We report a case of a previously healthy young female who presented with imaging-confirmed right-sided sacroiliitis 10 days after developing dengue fever. This is the first reported case that shows a possible link between dengue infection and development of arthritis...
November 1, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29075521/imaging-of-juvenile-spondyloarthritis-part-i-classifications-and-radiographs
#8
REVIEW
Iwona Sudoł-Szopińska, Piotr Gietka, Michał Znajdek, Genowefa Matuszewska, Magdalena Bogucevska, Ljubinka Damjanovska-Krstikj, Slavcho Ivanoski
Juvenile spondyloarthropathies are manifested mainly by symptoms of peripheral arthritis and enthesitis. By contrast with adults, children rarely present with sacroiliitis and spondylitis. Imaging and laboratory tests allow early diagnosis and treatment. Conventional radiographs visualize late inflammatory lesions and post-inflammatory complications. Early diagnosis is possible with the use of ultrasonography and magnetic resonance imaging. The first part of the article presents classifications of juvenile spondyloarthropathies and discusses their radiographic presentation...
September 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29073348/gut-microbiota-perturbations-in-reactive-arthritis-and-post-infectious-spondyloarthritis
#9
Julia Manasson, Nan Shen, Helga R Garcia Ferrer, Carles Ubeda, Isa Iraheta, Adriana Heguy, Joan M Von Feldt, Luis R Espinoza, Abraham Garcia Kutzbach, Leopoldo N Segal, Alexis Ogdie, Jose C Clemente, Jose U Scher
OBJECTIVE: Reactive arthritis (ReA) is an inflammatory disorder occurring several weeks after gastrointestinal or genitourinary infections. HLA-B27 positivity is considered a risk factor, though not necessarily predictive of disease incidence. Among non-genetic factors, the intestinal microbiome may play a role in disease susceptibility. The objective of this study was to characterize the gut microbiota and host gene interactions in ReA and post-infectious spondyloarthritis. METHODS: Adult peripheral spondyloarthritis and control subjects with preceding infections that did not develop arthritis were prospectively recruited from a highly prevalent geographic region...
October 26, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29068987/membranous-nephropathy-in-a-patient-with-ankylosing-spondylitis-a-case-report
#10
Ruiying Chen, Fang Li, Qionghong Xie, Jun Xue, Lingyun Lai, Shaojun Liu, Liyin Zhang, Chuanming Hao
RATIONALE: Renal complications in ankylosing spondylitis (AS) were rarely observed, and proteinuria associated with AS can be seen often due to amyloidosis in this kind of complications, while membranous nephropathy (MN) is seldom considered. This article reports a case of coexistence of AS and MN, to provide the exact relationship of these 2 entities and recognized some causes of renal involvement in AS. PATIENT CONCERNS: A 44-year-old female presented with pain of the left leg for 4 years and pedal edema for 2 weeks...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29065931/relevance-of-structural-damage-in-the-sacroiliac-joints-for-the-functional-status-and-spinal-mobility-in-patients-with-axial-spondyloarthritis-results-from-the-german-spondyloarthritis-inception-cohort
#11
Mikhail Protopopov, Joachim Sieper, Hildrun Haibel, Joachim Listing, Martin Rudwaleit, Denis Poddubnyy
BACKGROUND: Functional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage in the sacroiliac joints (SIJ) on physical function and spinal mobility in axSpA has not been studied so far. The objective of the study was to analyze the impact of radiographic sacroiliitis on functional status and spinal mobility in patients with axSpA. METHODS: In total, 210 patients with axSpA were included in the analysis...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29050160/-value-of-mdixon-quant-sequence-diffusion-weighted-imaging-in-quantitatively-diagnosing-the-sacroiliitis-stages
#12
Y Y An, H X Li, Y Zhan, X W Lei
Objective: To evaluate the value of mDIXON-Quant sequence, diffusion-weighted imaging (DWI) in quantitative diagnosing of the sacroiliitis stages in patients with ankylosing spondylitis (AS). Methods: Based on the Bath Ankylosing Spondylitis Activity Index (BASDAI) and laboratory parameters, a total of 51 patients were diagnosed with AS. They were divided into two groups as early active group (n=20) and chronic active group (n=31), and at the same time, 25 healthy people from Tianjin were included as control group...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29043434/-spondyloarthritides
#13
M Rudwaleit
Spondyloarthritides (SpA) are inflammatory rheumatic diseases affecting the axial skeleton, peripheral joints and entheses, and also manifest at extraskeletal sites. According to the more recently introduced nomenclature, predominant axial SpA is distinguished from predominant peripheral SpA. Axial SpA is further divided into radiographic and nonradiographic axial SpA. Genetic factors are relevant, with HLA-B27 being most important. The interleukin 23/17 pathway seems to be relevant and points towards new therapeutic targets...
October 17, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29042704/alternative-to-rituximab-therapy-for-a-patient-with-ankylosing-spondylitis-who-was-unable-to-continue-anti-tnf-therapy
#14
Eri Katsuyama, Hiroshi Wakabayashi, Ken-Ei Sada, Sumie Hiramatsu, Yoshia Miyawaki, Michiko Morishita, Keiji Ohashi, Haruki Watanabe, Takayuki Katsuyama, Sonia Zeggar, Mariko Narazaki, Noriko Tatebe, Katsue Sunahori-Watanabe, Tomoko Kawabata, Jun Wada
We herein present a case of a 38-year-old man who had bamboo spine and severe sacroiliitis and who was diagnosed with ankylosing spondylitis (AS). Infliximab (IFX) markedly improved the axial symptom but was discontinued due to the side effect of peripheral neuropathy. Switching from IFX to etanercept worsened the side effect. Rituximab (RTX) administration elicited a good response without side effects. RTX might be a suitable option for AS therapy when TNF inhibitors are difficult to use.
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29017176/oxygen-ozone-autohemotherapy-in-sacroiliitis
#15
Alparslan Bayram Çarli, Mehmet Incedayi
No abstract text is available yet for this article.
October 10, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28987663/radiography-abdominal-ct-and-mri-compared-with-sacroiliac-joint-ct-in-diagnosis-of-structural-sacroiliitis
#16
Julian Melchior, Yusef Azraq, Isabelle Chary-Valckenaere, Anne-Christine Rat, Marion Reignac, Pedro Texeira, Alain Blum, Damien Loeuille
OBJECTIVE: To assess the performance of pelvic plain radiograph (radiography), abdominal CT and sacroiliac joint MRI (MRI) compared with sacroiliac joints CT (SI joint CT) for the diagnosis of structural sacroiliitis in a population suffering from spondyloarthritis (SpA) meeting the New York or ASAS criteria. METHODS: All SpA patients eligible for biologic treatment who received a pre-therapeutic check-up including the four imaging techniques in the same year were selected from 2005 to 2012...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28980897/comparison-of-patients-with-familial-mediterranean-fever-accompanied-with-sacroiliitis-and-patients-with-juvenile-spondyloarthropathy
#17
Hafize Emine Sönmez, Ezgi Deniz Batu, Selcan Demir, Yelda Bilginer, Seza Özen
OBJECTIVES: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease manifesting with self-limited recurrent febrile attacks and polyserositis. Acute recurrent monoarthritis is the most common form of musculoskeletal involvement in FMF; however, up to 5% of FMF patients may develop chronic joint diseases including sacroiliitis. It is difficult to distinguish whether sacroiliitis is a musculoskeletal finding of FMF or whether this is the coexistence of two diseases, FMF and SpA...
September 26, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28976332/bone-single-photon-emission-computed-tomography-in-the-detection-of-sacroiliitis-in-seronegative-spondyloarthritis-a-comparison-with-magnetic-resonance-imaging
#18
Theodoros Pipikos, Dimitrios Kassimos, George Angelidis, John Koutsikos
OBJECTIVE: Seronegative spondyloarthritis (SpA) is characterized by chronic inflammation affecting the axial skeleton, entheses and occasionally peripheral joints. The involvement of the sacroiliac joints, sacroiliitis, is considered as a pathognomonic radiographic finding. Magnetic resonance imaging (MRI) is the method of choice for its early detection. Bone scintigraphy (BS) is characterized by high sensitivity in the diagnosis of bone and articular diseases. Limited value of BS in the diagnosis of sacroiliitis may be attributed to the use of planar imaging...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28957558/analysis-of-dedicated-sacroiliac-views-to-improve-reliability-of-conventional-pelvic-radiographs
#19
COMPARATIVE STUDY
Ahmed Omar, Ismail Sari, Mohamed Bedaiwi, David Salonen, Nigil Haroon, Robert D Inman
Objective: To compare the antero-posterior (AP) pelvis view with the Ferguson view of the SI joint in order to resolve whether one modality has a clear advantage for grading of sacroiliitis. Methods: One hundred and nine patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) criteria for axial spondyloarthritis who had AP pelvis and Ferguson views on the same day were identified from an axial spondyloarthritis clinic registry. Two rheumatologists independently scored the AP pelvis and Ferguson views according to modified New York (NY) criteria...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28917996/poor-efficacy-of-tnf-inhibitors-in-non-radiographic-axial-spondyloarthritis-in-the-absence-of-objective-signs-a-bicentric-retrospective-study
#20
Céline Vidal, Cédric Lukas, Bernard Combe, Francis Berenbaum, Yves Marie Pers, Christian Jorgensen, Jérémie Sellam, Jacques Morel
OBJECTIVE: To compare BASDAI 50 response rate to TNFi in axial spondyloarthritis (axSpA) depending on the presence or not of objective signs of axSpA and to look for predictive factors of TNFi efficacy. METHODS: Patients diagnosed with axSpA according to ASAS criteria "clinical arm" and treated between January 2001 and September 2015 with TNFi were included. First group included patients with at least one objective sign such as arthritis, dactylitis, enthesitis, uveitis, inflammatory bowel disease, elevated C-reactive protein or radiological sacroiliitis, and second group included non-radiographic axSpA (nr-axSpA) patients without any objective sign corresponding to patients with inflammatory back pain and either a good response to NSAID or a SpA family history...
September 13, 2017: Joint, Bone, Spine: Revue du Rhumatisme
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