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https://www.readbyqxmd.com/read/28329487/apremilast-for-the-treatment-of-psoriatic-arthritis
#1
Brent C Martin, Logan W Thomas, Francis J Dann
Psoriatic arthritis (PsA) is a chronic inflammatoryarthropathy that affects joints and entheses andis associated with psoriasis (PsO). There are fiveclinical patterns of PsA: symmetrical polyarthritis,distal interphalangeal arthropathy, asymmetricaloligoarthritis, arthritis mutilans, and spondylitis, withor without sacroiliitis. Concerning PsA, the goals oftherapy are to control inflammation, prevent articulardamage, and reduce discomfort in the affected joints.Although there are many therapeutic options forthe treatment of PsAs, physicians most often beginwith nonsteroidal anti-inflammatory drugs (NSAIDs)for mild disease...
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28324118/early-onset-polymyalgia-rheumatica-two-rare-cases-under-age-of-50
#2
Jinyoung Park, Duk Hyun Sung
Polymyalgia rheumatica (PMR) is almost an exclusive disease of adults over the age of 50, and only a few cases have been reported. Two 46-year-old females visited our locomotor pain clinic with multiple joint pain with increased acute phase reactants. Rheumatologic markers, and HLA-B27 were checked. Serum protein electrophoresis and serum immunofixation electrophoresis, imaging studies including plane image, sonography, and magnetic resonance image was done. (18)F-Fludeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) showed characteristic findings of PMR, without evidences of sacroiliitis...
March 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28303752/bone-morphogenetic-proteins-and-dickkopf-1-in-ankylosing-spondylitis
#3
H-T Liao, Y-F Lin, C-Y Tsai, T-C Chou
OBJECTIVES: To determine bone morphogenetic proteins (BMPs) and Dickkopf homologue-1 (Dkk-1) levels in ankylosing spondylitis (AS). METHOD: Serum BMPs and Dkk-1 were measured in 72 AS patients and 30 healthy controls. For AS patients, we recorded the demographic data, disease activity, functional index, and global assessment with questionnaires, and image changes with roentgenography. We also measured human leucocyte antigen-B27 and systemic inflammatory reactants...
March 17, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28293463/chikungunya-and-bilateral-sacroiliitis-is-there-a-link
#4
Muhammad K Nisar, Christabel Packianathan
No abstract text is available yet for this article.
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28293449/subclinical-enthesopathy-in-patients-with-psoriasis-and-its-association-with-other-disease-parameters-a-power-doppler-ultrasonographic-study
#5
Abdelhafeez Moshrif, Ahmed Mosallam, Essam Elden M Mohamed, Wesam Gouda, Mostafa Doma
OBJECTIVE: This study aimed to determine the prevalence of subclinical enthesopathy in patients with psoriasis using power Doppler ultrasonography (PDUS) and its association with other disease parameters. MATERIAL AND METHODS: A total of 50 patients with psoriasis (31 females) aged 19-70 years underwent a thorough clinical examination that included assessment of body mass index (BMI) and psoriasis area and severity index (PASI) score. Measurements of inflammatory markers, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum uric acid, and plain radiography of the heels, knees, and sacroiliac joints were performed for all patients...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28286523/interobserver-agreement-in-magnetic-resonance-of-the-sacroiliac-joints-in-patients-with-spondyloarthritis
#6
Juan C Rueda, Sofia Arias-Correal, Andres Y Vasquez, Enrique Calvo, Paola Peña, Marlon Porras, Jose-Ignacio Angarita, Eugenia-Lucia Saldarriaga, Ana M Santos, John Londono
Background. Clinical, laboratory, and radiologic parameters are used for diagnosis and classification of spondyloarthritis (SpA). Magnetic resonance imaging (MRI) of sacroiliac (SI) joints is being increasingly used to detect early sacroiliitis. We decided to evaluate the interobserver agreement in MRI findings of SI joints of SpA patients between a local radiologist, a rheumatologist, and an expert radiologist in musculoskeletal diseases. Methods. 66 MRI images of the SI joints of patients with established diagnosis of SpA were evaluated...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28265268/brucella-and-osteoarticular-cell-activation-partners-in-crime
#7
REVIEW
Guillermo H Giambartolomei, Paula C Arriola Benitez, M Victoria Delpino
Osteoarticular brucellosis is the most common presentation of human active disease although its prevalence varies widely. The three most common forms of osteoarticular involvement are sacroiliitis, spondylitis, and peripheral arthritis. The molecular mechanisms implicated in bone damage have been recently elucidated. B. abortus induces bone damage through diverse mechanisms in which TNF-α and the receptor activator of nuclear factor kappa-B ligand (RANKL)-the natural modulator of bone homeostasis are involved...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28250859/-18-f-fdg-pet-ct-for-the-diagnosis-of-malignant-and-infectious-complications-after-solid-organ-transplantation
#8
Nastassja Muller, Romain Kessler, Sophie Caillard, Eric Epailly, Fabrice Hubelé, Céline Heimburger, Izzie-Jacques Namer, Raoul Herbrecht, Cyrille Blondet, Alessio Imperiale
PURPOSE: Infection and malignancy represent two common complications after solid organ transplantation, which are often characterized by poorly specific clinical symptomatology. Herein, we have evaluated the role of (18)F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) in this clinical setting. METHODS: Fifty-eight consecutive patients who underwent FDG PET/CT after kidney, lung or heart transplantation were included in this retrospective analysis...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28248672/can-imaging-modalities-be-used-as-follow-up-criteria-after-brucellar-sacroiliitis-treatment
#9
Aybars Bilgeturk, Hanefi Cem Gul, Ahmet Karakas, Gurkan Mert, Cumhur Artuk, Can Polat Eyigun
INTRODUCTION: This study aimed to identify a follow-up modality that can be used to evaluate therapeutic responses in patients receiving treatment for brucellar sacroillitis and to determine whether antibiotherapy can be stopped. METHODOLOGY: A total of 32 patients with sacroiliac joint involvement demonstrated via magnetic resonance imaging or bone scintigraphy were followed up and treated. Patients received 200 mg/day of doxycycline and 600-900 mg/day of rifampicin for 3-21 months, and 1 g/day of streptomycin for 21 days...
February 28, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28160002/radiographic-sacroiliitis-develops-predictably-over-time-in-a-cohort-of-familial-spondyloarthritis-followed-longitudinally
#10
Félicie Costantino, Nadine Zeboulon, Roula Said-Nahal, Maxime Breban
No abstract text is available yet for this article.
February 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/28148698/the-juvenile-psoriatic-arthritis-cohort-in-the-carra-registry-clinical-characteristics-classification-and-outcomes
#11
Devy Zisman, Dafna D Gladman, Matthew L Stoll, Vibeke Strand, Idit Lavi, Joyce J Hsu, Elizabeth D Mellins
OBJECTIVE: Children with clinically diagnosed juvenile psoriatic arthritis (JPsA) who were enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry (CARRA-JPsA) were classified according to pediatric International League of Associations for Rheumatology (ILAR) and adult criteria [Classification criteria for Psoriatic Arthritis (CASPAR)]. Data on demographic and clinical features at baseline and 1-year followup were analyzed and compared. METHODS: Cross-sectional analysis was performed of CARRA-JPsA patients enrolled between May 2010 and December 2013 and stratified according to age at disease onset (≤ or > 4 yrs)...
February 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28129460/diagnostic-value-and-validity-of-early-spondyloarthritis-features-results-from-the-esperanza-cohort
#12
Beatriz E Joven, Victoria Navarro-Compán, Jose Rosas, Pilar Fernandez Dapica, Pedro Zarco, Eugenio De Miguel
OBJECTIVE: To evaluate the validity of different spondyloarthritis (SpA) features included in the Berlin diagnostic algorithm and the ASAS classification criteria in an early cohort. PATIENTS AND METHODS: This was a longitudinal multicentre study including patients with suspected SpA from the ESPeranza cohort. Subjects were ≤45 years old and SpA symptom duration was 3-24 months. Patients with axial symptoms were selected and categorized according to diagnosis (yes/no) of axial SpA (axSpA)...
January 27, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28103710/radiography-and-abdominal-ct-compared-with-sacroiliac-joint-ct-in-the-diagnosis-of-sacroiliitis
#13
Julian Melchior, Yusef Azraq, Isabelle Chary-Valckenaere, Anne-Christine Rat, Pedro Texeira, Alain Blum, Damien Loeuille
Background The presence of structural sacroiliitis is strong evidence for the diagnosis of spondyloarthritis (SpA). Purpose To assess the performance of abdominal computed tomography (CT) and pelvic plain radiography for the diagnosis of structural sacroiliitis compared with sacroiliac CT (SI joint CT) considered the reference technique in patients with SpA. Material and Methods All SpA patients eligible for biologic treatment were selected from 2005 to 2012. An assessment of sacroiliitis was based on radiography according to the modified New York criteria and on abdominal CT and SI joint CT scans depending on the presence of erosion on at least two consecutive slices...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28087505/2016-update-of-the-asas-eular-management-recommendations-for-axial-spondyloarthritis
#14
Désirée van der Heijde, Sofia Ramiro, Robert Landewé, Xenofon Baraliakos, Filip Van den Bosch, Alexandre Sepriano, Andrea Regel, Adrian Ciurea, Hanne Dagfinrud, Maxime Dougados, Floris van Gaalen, Pál Géher, Irene van der Horst-Bruinsma, Robert D Inman, Merryn Jongkees, Uta Kiltz, Tore K Kvien, Pedro M Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compàn, Salih Ozgocmen, Fernando M Pimentel-Santos, John Reveille, Martin Rudwaleit, Jochen Sieper, Percival Sampaio-Barros, Dieter Wiek, Jürgen Braun
To update and integrate the recommendations for ankylosing spondylitis and the recommendations for the use of tumour necrosis factor inhibitors (TNFi) in axial spondyloarthritis (axSpA) into one set applicable to the full spectrum of patients with axSpA. Following the latest version of the European League Against Rheumatism (EULAR) Standardised Operating Procedures, two systematic literature reviews first collected the evidence regarding all treatment options (pharmacological and non-pharmacological) that were published since 2009...
January 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28087263/sacroiliitis-due-to-calcium-pyrophosphate-deposition-disease
#15
Maria Jose Moreno Martinez, Manuel J Moreno Ramos, Luis F Linares Ferrando
No abstract text is available yet for this article.
January 10, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28040706/familial-mediterranean-fever-associated-diseases-in-children
#16
Z Birsin Özçakar, Nilgün Çakar, Nermin Uncu, Banu Acar Çelikel, Fatoş Yalçınkaya
BACKGROUND: MEditerranean FeVer (MEFV) gene encodes for the pyrin protein and a mutated pyrin is associated with a prolonged or augmented inflammation. Hence, various diseases were reported to be associated with familial Mediterranean fever (FMF) or carriers of MEFV mutations. However, systematic evaluation of all associated diseases in children with FMF has not been done previously. AIM: The aim of this study was to investigate the frequency and type of FMF-associated diseases in children...
December 30, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28039416/symptomatic-unilateral-sacroiliitis-as-a-first-presenting-feature-of-igg4-related-disease-with-successful-response-to-treatment-after-1-year-of-follow-uparticle
#17
Anna Jamnitski, Odile van Hall, Niek de Vries, Paul van der Valk, Willem F Lems, Irene E van der Horst-Bruinsma
No abstract text is available yet for this article.
December 30, 2016: Rheumatology
https://www.readbyqxmd.com/read/28004967/the-value-of-the-t2-weighted-multipoint-dixon-sequence-in-mri-of-sacroiliac-joints-for-the-diagnosis-of-active-and-chronic-sacroiliitis
#18
Ali Özgen
OBJECTIVE: The objective of this study was to determine the value of the T2-weighted multipoint Dixon technique as a single sequence in MRI of the sacroiliac joints for the diagnosis of active and chronic sacroiliitis. SUBJECTS AND METHODS: The T2-weighted multipoint Dixon sequence with water-only, in-phase, opposed-phase, and fat-only images was added to a routine MRI protocol, which included T1-weighted, fat-saturated T2-weighted, and contrast-enhanced fat-saturated T1-weighted sequences, for imaging 73 patients...
March 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28002357/pediatric-sacroiliitis-clinical-and-microbiologic-differences-between-infants-and-children-adolescents
#19
Ambra Donzelli, Eleftheria Samara, Vassiliki Spyropoulou, Céline Juchler, Dimitri Ceroni
BACKGROUND: The aim of this study was to improve knowledge of pediatric pyogenic sacroiliitis (PSI) in the pediatric population based on a consecutive case series. METHOD: We conducted a single-center cross-sectional study on 16 patients admitted to the emergency department of our Hospital between January 1990 and December 2015 with a confirmed diagnosis of PSI. The patients were divided into 2 groups by age: infants (6 months - 4 years) and children-adolescents (4-16 years)...
December 19, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27994095/diffusion-weighted-imaging-is-a-sensitive-biomarker-of-response-to-biologic-therapy-in-enthesitis-related-arthritis
#20
Timothy J P Bray, Kanimozhi Vendhan, Nicola Ambrose, David Atkinson, Shonit Punwani, Corinne Fisher, Debajit Sen, Yiannis Ioannou, Margaret A Hall-Craggs
OBJECTIVE: The aim was to evaluate diffusion-weighted imaging (DWI) as a tool for measuring treatment response in adolescents with enthesitis-related arthropathy (ERA). METHODS: Twenty-two adolescents with ERA underwent routine MRI and DWI before and after TNF inhibitor therapy. Each patient's images were visually scored by two radiologists using the Spondyloarthritis Research Consortium of Canada system, and sacroiliac joint apparent diffusion coefficient (ADC) and normalized ADC (nADC) were measured for each patient...
December 19, 2016: Rheumatology
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