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https://www.readbyqxmd.com/read/29774755/radiographic-progression-in-non-radiographic-axial-spondyloarthritis
#1
Mikhail Protopopov, Denis Poddubnyy
Non-radiographic axial spondyloarthritis (nr-axSpA) represents a subtype of axial spondyloarthritis (axSpA) with no significant structural damage in sacroiliac joints and spine. Despite that, patients with nr-axSpA demonstrate a substantial burden of illness, and a considerable share of them might progress to radiographic axSpA (r-axSpA) over time. The amount and quality of published data allows crude estimation of progression rate and factors related to a higher risk of progression. Areas covered: This review discusses the available data reporting the rates and predictors of radiographic progression in the sacroiliac joints and in the spine in patients with nr-axSpA as well as predisposing factors for such a progression...
May 18, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29692328/infectious-sacroiliitis-retrospective-analysis-of-18-case-patients
#2
M Matt, E Denes, P Weinbreck
INTRODUCTION: Few infectious sacroiliitis reports are available in the literature. There is no standard clinical presentation, and diagnosis and treatments are therefore usually delayed. We aimed to describe this infection. METHODS: We performed a single-center retrospective study of patients hospitalized in the infectious diseases unit of the Limoges University Hospital from January 1, 2006 to January 31, 2016. We included all patients presenting with infectious monoarthritis of native sacroiliac joint...
April 21, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29686444/septic-arthritis-of-the-sacroiliac-joint
#3
Patryk J Woytala, Agata Sebastian, Katarzyna Błach, Jurand Silicki, Piotr Wiland
Septic arthritis is an inflammation of a joint caused directly by various microorganisms. It is often characterized by many unspecific symptoms. Bacteria is the most often etiological factor. We present a case report of a 76-years old woman with a unilateral septic arthritis of the sacroiliac joint. Bacterial sacroiliitis should be taken into account in patients with sacroiliitis and fever onset. Proper diagnosis can be very often difficult and delayed but fast implementation of antibiotic therapy is extremely important in the treatment process...
2018: Reumatologia
https://www.readbyqxmd.com/read/29681195/biologics-for-treating-axial-spondyloarthritis
#4
Alexis Jones, Coziana Ciurtin, Mediola Ismajli, Maria Leandro, Raj Sengupta, Pedro M Machado
Spondyloarthritis (SpA) encompasses a heterogeneous group of diseases sharing genetic, immunological, clinical and imaging features. Axial spondyloarthritis (axSpA) refers to a subgroup characterised predominately by inflammation of the axial skeleton with subsequent symptoms of chronic (often inflammatory) back pain and sacroiliitis. There is a strong association with the major histocompatibility complex (MHC) class I allele human leukocyte antigen (HLA) B27. In the last decade, there has been significant progress in earlier detection of the disease and the molecular mechanisms involved in its pathogenesis...
April 21, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#5
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29674852/long-term-prospective-outcomes-after-minimally-invasive-trans-iliac-sacroiliac-joint-fusion-using-triangular-titanium-implants
#6
Emily Darr, S Craig Meyer, Peter G Whang, Don Kovalsky, Clay Frank, Harry Lockstadt, Robert Limoni, Andy Redmond, Philip Ploska, Michael Y Oh, Daniel Cher, Abhineet Chowdhary
Background: Minimally invasive sacroiliac joint fusion (SIJF) has become an increasingly accepted surgical option for chronic sacroiliac (SI) joint dysfunction, a prevalent cause of unremitting low back/buttock pain. Objective: The objective of this study was to report clinical and functional outcomes of SIJF using triangular titanium implants (TTI) in the treatment of chronic SI joint dysfunction due to degenerative sacroiliitis or sacroiliac joint (SIJ) disruption at 3 years postoperatively...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29672806/sacroiliitis-in-axial-spondyloarthritis-assessing-morphology-and-activity
#7
Lennart Jans, Niels Egund, Iris Eshed, Iwona Sudoł-Szopińska, Anne Grethe Jurik
OBJECTIVE:  To review the strengths, limitations, and new insights in the anatomy and magnetic resonance imaging (MRI) features of active and structural lesions of sacroiliitis in spondyloarthritis. DISCUSSION:  MRI plays a key role in the diagnosis and follow-up of sacroiliitis in spondyloarthritis. MRI of the sacroiliac joints in affected patients may show active lesions such as bone marrow edema, capsulitis, enthesitis, or synovitis as well as structural changes such as erosion, fat infiltration, sclerosis, backfill, and ankylosis...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29658210/septic-sacroiliitis-a-diagnostic-challenge-for-the-clinician
#8
Asaf Shemer, Iris Eshed, Moshe Levinkopf
No abstract text is available yet for this article.
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29629794/does-the-addition-of-dwi-to-fluid-sensitive-conventional-mri-of-the-sacroiliac-joints-improve-the-diagnosis-of-sacroiliitis
#9
Luis S Beltran, Mohammad Samim, Soterios Gyftopoulos, Mary T Bruno, Catherine N Petchprapa
OBJECTIVE: The purpose of this study was to determine whether adding DWI to conventional MRI of the sacroiliac joints improves the diagnostic performance of MRI readers in the detection of sacroiliitis. MATERIALS AND METHODS: MR images of the sacroiliac joints of 63 patients with lower back pain obtained between January 2016 and December 2016 were analyzed retrospectively. Three readers reviewed the MRI studies for bone marrow edema lesions around the sacroiliac joints as a marker of active sacroiliitis and gave a diagnostic confidence score of 0-4 using MRI without DWI and MRI with DWI in separate sessions...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29609643/clinical-features-of-children-with-enthesitis-related-juvenile-idiopathic-arthritis-juvenile-spondyloarthritis-followed-in-a-french-tertiary-care-pediatric-rheumatology-centre
#10
Maxime Goirand, Sylvain Breton, Frédéric Chevallier, Ngoc-Phoi Duong, Florence Uettwiller, Isabelle Melki, Richard Mouy, Carine Wouters, Brigitte Bader-Meunier, Chantal Job-Deslandre, Pierre Quartier
BACKGROUND: Childhood-onset spondyloarthropathies usually start with enthesitis and peripheral arthritis. However, axial disease may develop afterward. Patients are most often classified, following revised (Edmonton 2011) ILAR criteria, as enthesitis-related arthritis, psoriatic arthritis, or unclassified juvenile idiopathic arthritis, particularly in cases of psoriasis in the patient or a first-degree relative. In adults, peripheral spondyloarthritis is classified by ASAS criteria. METHODS: We retrospectively studied patients with childhood-onset spondyloarthropathies followed for more than one year in our referral centre...
April 2, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29596210/sacroiliitis-in-children-with-familial-mediterranean-fever
#11
Fatma Aydin, Z Birsin Özçakar, Nilgün Çakar, Elif Çelikel, Nermin Uncu, Banu Çelikel Acar, Fatoş Yalçinkaya
BACKGROUND/OBJECTIVE: Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterized by recurrent, self-limited attacks of fever with serositis. Various diseases were reported to be associated with FMF. The aim of this study was to investigate the frequency and characteristics of sacroiliitis in children with FMF. METHODS: Files of FMF patients who had been seen in 2 reference hospitals in Ankara were retrospectively evaluated. Patients with FMF and concomitant sacroiliitis were included to the study...
March 29, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29595277/-the-role-of-magnetic-resonance-imaging-in-diagnostics-of-axial-spondyloarthritis
#12
Martin Žlnay
Axial spondyloarthritis (SpA) is a chronic inflammatory rheumatic disorder that primary affects axial skeleton. It comprises wide spectrum of patients with immune mediated spine inflammation, from early, so called non-radiographic axial spondyloarthritis to clinically evident ankylosing spondylitis. Conventional radiography is still the cornerstone of diagnosis, evaluation and classification of SpA. However, it has limitations in early disease, because it can only depict the consequences of inflammation for its inability to visualize soft tissue abnormalities within bone marrow...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29595276/-axial-spondyloarthritis
#13
Leona Procházková, Vladimír Červeňák, Miroslav Souček
Axial spondyloarthritis (axSpA) is a common name for the non-radiographic form of the disease and radiographic axial spondyloarthritis, known as ankylosing spondylitis (AS). The disease is typically manifested at a young age, characterized by affection of axial skeleton, and in the most severe form can lead to complete ankylosis of the spine. Etiology of diseases have not yet been clarified, however, the genetic background, especially the binding to HLA-B27 antigen, is obvious. Clinical manifestations are dominated by chronic pain in the lower pain or buttocks that occurred in young age, in a large proportion of patients having the character of so-called inflammatory pain...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29590484/calcium-pyrophosphate-deposition-disease-induced-sacroiliitis
#14
Henk A Martens, Steven C van Bokhoven, Annemiek A M E Stenger
No abstract text is available yet for this article.
March 26, 2018: Rheumatology
https://www.readbyqxmd.com/read/29584927/impact-of-replacing-radiographic-sacroiliitis-by-magnetic-resonance-imaging-structural-lesions-on-the-classification-of-patients-with-axial-spondyloarthritis
#15
Pauline A Bakker, Rosaline van den Berg, Manouk de Hooge, Miranda van Lunteren, Zineb Ez-Zaitouni, Karen M Fagerli, Robert Landewé, Maikel van Oosterhout, Roberta Ramonda, Monique Reijnierse, Floris A van Gaalen, Désirée van der Heijde
Objectives: To investigate in patients with chronic back pain of a short duration, the utility of adding structural MRI lesions of the SI joints to the imaging criterion of the Assessment of SpondyloArthritis International Society (ASAS) axial SpA (axSpA) criteria and the utility of replacement of radiographic sacroiliitis by structural MRI lesions. Methods: MRI STIR (inflammation, MRI-SI), MRI T1-weighted images (structural lesions, MRI-SI-s) and radiographs of the SI joints of patients in the SPondyloArthritis Caught Early-cohort (chronic back pain: ⩾3 months, ⩽2 years; onset <45 years) were scored by two well-calibrated readers...
March 23, 2018: Rheumatology
https://www.readbyqxmd.com/read/29579265/imaging-of-the-sacroiliac-joints-is-important-for-diagnosing-early-axial-spondyloarthritis-but-not-all-decisive
#16
Zineb Ez-Zaitouni, Robert Landewé, Miranda van Lunteren, Pauline A Bakker, Karen M Fagerli, Roberta Ramonda, Lennart T H Jacobsson, Désirée van der Heijde, Floris A van Gaalen
Objectives: To evaluate the contribution of the results of sacroiliac imaging to diagnosis and to the level of confidence in diagnosis in patients presenting with chronic back pain (CBP) and suspected of having axial spondyloarthritis (axSpA). Methods. Data from 513 patients from the SPondyloArthritisCaughtEarly cohort with CBP (⩾3 months, ⩽2 years, onset <45 years) were analysed after full diagnostic work-up. Rheumatologists were asked not only to provide a diagnosis before and after the imaging results had been provided to them, but also to provide the level of confidence of this diagnosis on an 11-point numerical scale...
March 20, 2018: Rheumatology
https://www.readbyqxmd.com/read/29564671/role-of-positron-emission-tomography-in-assessing-disease-activity-in-ulcerative-colitis-comparison-with-biomarkers
#17
Neha Berry, Saroj Kant Sinha, Anish Bhattacharya, K K Prasad, Chetana Vaishnavi, Kim Vaiphei, Jayanta Samanta, Raghavendra Prasada, Narendra Dhaka, Rakesh Kochhar
BACKGROUND: Disease activity in ulcerative colitis (UC) is best assessed clinically by Mayo score. 18-Fluorodeoxyglucose positron emission tomography-computerized tomography (FDG PET-CT) is a noninvasive imaging technique to assess extent, disease activity and response to treatment of UC, especially in high risk population or patients unwilling for endoscopy. AIMS: We conducted a prospective observational study with the aim of assessing and correlating UC disease activity by clinical criteria, endoscopy, histology, serum and fecal biomarkers, and FDG PET-CT...
March 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29545448/in-early-axial-spondyloarthritis-increasing-disease-activity-is-associated-with-worsening-of-health-related-quality-of-life-over-time
#18
Miranda van Lunteren, Zineb Ez-Zaitouni, Anoek de Koning, Hanne Dagfinrud, Roberta Ramonda, Lennart Jacobsson, Robert Landewé, Désirée van der Heijde, Floris A van Gaalen
OBJECTIVE: In early axial spondyloarthritis (axSpA), data are lacking about the relationship between disease activity and health-related quality of life (HRQOL). We assessed and quantified the association between change in Ankylosing Spondylitis Disease Activity Score (ASDAS) and HRQOL over time in early axSpA. METHODS: Baseline and 1-year data of patients with axSpA fulfilling the Assessment of Spondyloarthritis international Society (ASAS) classification criteria from the SPondyloArthritis Caught Early (SPACE) cohort were analyzed...
March 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29542383/predisposition-of-six-well-characterized-micrornas-to-syndesmophytes-among-chinese-patients-with-ankylosing-spondylitis
#19
Wenxue Yang, Xiaoping Yan, Qisheng Xia, Qingwen Tao, Xiaowei Gan, Yingze Zhang, Zhihua Chen, Weiping Kong
OBJECTIVES: We quantified the expression of six well-characterized microRNAs in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients. METHODS: This is a cross-sectional study involving 46 AS patients (23/23 with/without syndesmophytes) and 22 healthy controls. MicroRNAs expression was quantified by real-time PCR. RESULTS: Six examined microRNAs were comparably expressed between AS patients without syndesmophytes and healthy controls (p>0...
March 15, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29538011/computed-tomography-in-axial-spondyloarthritis
#20
Sovira Tan, Michael M Ward
PURPOSE OF REVIEW: Computed tomography (CT) is increasingly being used in ankylosing spondylitis (AS) for imaging the spine and sacroiliac joint (SIJ). We review new insights to diagnosis and evaluation revealed by the use of CT. RECENT FINDINGS: Studies using low-dose CT in AS to detect syndesmophytes can image the entire spine, but semiquantitative scoring of the scans by human readers decreases the reliability and validity of this method. The thoracic spine is the segment most involved with syndesmophytes...
March 13, 2018: Current Opinion in Rheumatology
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