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Miranda van Lunteren, Zineb Ez-Zaitouni, Anoek de Koning, Hanne Dagfinrud, Roberta Ramonda, Lennart Jacobsson, Robert Landewé, Désirée van der Heijde, Floris A van Gaalen
OBJECTIVE: In early axial spondyloarthritis (axSpA), data are lacking about the relationship between disease activity and health-related quality of life (HRQOL). We assessed and quantified the association between change in Ankylosing Spondylitis Disease Activity Score (ASDAS) and HRQOL over time in early axSpA. METHODS: Baseline and 1-year data of patients with axSpA fulfilling the Assessment of Spondyloarthritis international Society (ASAS) classification criteria from the SPondyloArthritis Caught Early (SPACE) cohort were analyzed...
March 15, 2018: Journal of Rheumatology
Wenxue Yang, Xiaoping Yan, Qisheng Xia, Qingwen Tao, Xiaowei Gan, Yingze Zhang, Zhihua Chen, Weiping Kong
OBJECTIVES: We quantified the expression of six well-characterized microRNAs in peripheral blood mononuclear cells to see whether they can predispose to syndesmophytes in ankylosing spondylitis (AS) patients. METHODS: This is a cross-sectional study involving 46 AS patients (23/23 with/without syndesmophytes) and 22 healthy controls. MicroRNAs expression was quantified by real-time PCR. RESULTS: Six examined microRNAs were comparably expressed between AS patients without syndesmophytes and healthy controls (p>0...
March 15, 2018: Modern Rheumatology
Sovira Tan, Michael M Ward
PURPOSE OF REVIEW: Computed tomography (CT) is increasingly being used in ankylosing spondylitis (AS) for imaging the spine and sacroiliac joint (SIJ). We review new insights to diagnosis and evaluation revealed by the use of CT. RECENT FINDINGS: Studies using low-dose CT in AS to detect syndesmophytes can image the entire spine, but semiquantitative scoring of the scans by human readers decreases the reliability and validity of this method. The thoracic spine is the segment most involved with syndesmophytes...
March 13, 2018: Current Opinion in Rheumatology
E Calle, L A González, C H Muñoz, D Jaramillo, A Vanegas, G Vásquez
Systemic lupus erythematosus (SLE) patients are at higher risk of developing opportunistic infections such as tuberculosis (TB), especially extrapulmonary forms like osteoarticular TB, compared to the general population. However, tuberculous sacroiliitis has been scarcely reported in these patients. We present a 34-year-old woman with SLE who developed articular tuberculosis simultaneously affecting the right sacroiliac joint and the left knee. The patient was successfully treated with antituberculosis therapy for nine months...
January 1, 2018: Lupus
Yong-Peng Lin, Yong-Jin Li, Bo-Lai Chen, Yu-Hai Guo
RATIONALE: Adult spinal epidermoid cyst (SEC) is a rare tumor. Lumbar laminectomy and tumor removal was a routine surgical procedure for adult spinal epidermoid cyst according to the literature, but postoperative lumbar instability and intractable low back pain may occur. In this study, we presented a brief report of an adult lumbar epidermoid cyst and introduced another surgical approach. PATIENT CONCERNS: This 28-year-old woman has been complaining of the severe right buttock pain and right thigh radiating pain for half a year...
January 2018: Medicine (Baltimore)
Janneke J de Winter, Marleen G van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen, Torsten Witte, Dominique L Baeten
BACKGROUND: Anti-CD74 IgG antibodies are reported to be elevated in patients with axial spondyloarthritis (axSpA). This study assessed the diagnostic value of anti-CD74 antibodies in patients with early axSpA. METHODS: Anti-CD74 IgG and IgA antibodies were first measured in an exploratory cohort of patients with radiographic axSpA (138 patients with ankylosing spondyloarthritis (AS)) and 57 healthy controls and then were measured in patients with early axSpA (n = 274) and with non-SpA chronic back pain (CBP) (n = 319), participating in the spondyloarthritis caught early (SPACE) prospective cohort study of patients under 45 years old with early back pain (for ≥ 3 months, but ≤ 2 years)...
March 1, 2018: Arthritis Research & Therapy
Mark Fleisher, Jan Marsal, Scott D Lee, Laura E Frado, Alyssa Parian, Burton I Korelitz, Brian G Feagan
BACKGROUND: Approximately 15-20% of ulcerative colitis patients and 20-40% of those with Crohn's disease experience extraintestinal manifestations (EIMs) of their inflammatory bowel disease (IBD). Clinicians who treat IBD must manage EIMs affecting multiple organs that variably correlate with intestinal disease activity. Vedolizumab is a monoclonal antibody for the treatment of IBD with a gut-selective mechanism of action. AIMS: This report evaluates whether vedolizumab is an effective treatment of EIMs, given its gut-specific mechanism of action...
February 26, 2018: Digestive Diseases and Sciences
Yushane C Shih, Brian P Beaubien, Qingshan Chen, Jonathan N Sembrano
BACKGROUND CONTEXT: Fusion typically consists of joint preparation, grafting and rigid fixation. Fusion has been successfully used to treat symptomatic disruptions of the SIJ and degenerative sacroiliitis using purpose-specific, threaded implants. The biomechanical performance of these systems is important but has not been studied. PURPOSE: To compare two techniques for placing primary (12.5mm) and secondary (8.5mm) implants across the SIJ. STUDY DESIGN: A human cadaveric biomechanical study of sacroiliac joint (SIJ) fixation...
February 23, 2018: Spine Journal: Official Journal of the North American Spine Society
Cédric Lukas, Catherine Cyteval, Maxime Dougados, Ulrich Weber
Recognition of axial spondyloarthritis (SpA) remains challenging, as no unique reference standard is available to ascertain diagnosis. Imaging procedures have been used for long in the field, in particular pelvic radiography, to capture structural changes evocative of sacroiliitis, the key feature in SpA. The introduction of MRI of the sacroiliac joints (SIJs) has led to a major shift in recognition of the disorder. MRI has been shown to detect the initial inflammatory processes, in particular osteitis depicted by bone marrow oedema, even in patients having not yet developed structural lesions...
2018: RMD Open
Ulrich Weber, Anne Grethe Jurik, Anna Zejden, Ejnar Larsen, Steen Hylgaard Jørgensen, Kaspar Rufibach, Christian Schioldan, Søren Schmidt-Olsen
OBJECTIVE: Low grade bone marrow edema (BME) was reported in the sacroiliac joints (SIJ) of 25% of healthy individuals and mechanical back pain patients, challenging the imaging discrimination from early spondyloarthritis (SpA). It is unknown whether stress injury in competition sports may trigger BME. We explored frequency and anatomical distribution of SIJ MRI lesions in recreational and elite athletes. METHODS: After pre-test calibration, semicoronal SIJ MRI scans of 20 recreational runners (RR) before/after running and 22 elite ice-hockey players (IP) were assessed by 3 blinded readers for BME and structural lesions using an SIJ quadrant-based module...
February 12, 2018: Arthritis & Rheumatology
Ennio Lubrano, Fabio Massimo Perrotta, Maria Manara, Salvatore D'Angelo, Olga Addimanda, Roberta Ramonda, Leonardo Punzi, Ignazio Olivieri, Carlo Salvarani, Antonio Marchesoni
OBJECTIVE: The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA). METHODS: In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease...
February 2018: Journal of Rheumatology
Hamdi Wafa, Miladi Saoussen, Kaffel Dhia, Zouch Imen, Kchir Mohamed Montacer
Background: Sarcoidosis is a multisystem granulomatous disease. Co-existence with spondyloarthritis (SA) has been more described as an adverse effect of anti-TNF α therapy than an association. We report herein a case of a typical sarcoidosis confirmed by histological proofs and an advanced SA with a bamboo column. Case Presentation: A 48-years-old woman presented with inflammatory back pain for 5 years and ankle swelling for 1 year. On physical examination, she had an exaggerated dorsal kyphosis and disappearance of lumbar lordosis with limitation in motion of the cervical and lumbar spine...
2018: Caspian Journal of Internal Medicine
Denis Poddubnyy, Joachim Listing, Hildrun Haibel, Sven Knüppel, Martin Rudwaleit, Joachim Sieper
Objectives: The aim of the study was to investigate the functional relevance of the development of structural damage in the spine in patients with early axial spondyloarthritis (axSpA). Methods: Altogether, 210 patients with early axSpA (symptom duration ⩽10 years) who completed a 2-year clinical and radiographic follow-up in the GErman SPondyloarthritis Inception Cohort were included. An association between structural damage in the spine [modified Stoke AS Spine Score (mSASSS)] and functional status (the BASFI) or spinal mobility (the BASMI) was assessed in a longitudinal linear mixed model analysis; both unstandardized (β) and standardized (β stand ) regression coefficients were calculated...
January 24, 2018: Rheumatology
Kwi Young Kang, Min Kyung Chung, Ha Neul Kim, Yeon Sik Hong, Ji Hyeon Ju, Sung-Hwan Park
OBJECTIVE: To examine factors related to a low trabecular bone score (TBS) and the association between TBS and vertebral fractures in patients with ankylosing spondylitis (AS). METHODS: One hundred patients (all male, aged < 50 yrs) who fulfilled the modified New York criteria for the classification of AS were enrolled. The TBS and bone mineral density (BMD) were assessed using dual-energy X-ray absorptiometry. Clinical variables, inflammatory markers, and the presence of vertebral fractures were also assessed...
March 2018: Journal of Rheumatology
Asaf Shemer, Iris Eshed, Moshe Levinkopf
No abstract text is available yet for this article.
January 2018: Israel Medical Association Journal: IMAJ
Paul W Millhouse, Andrew J Miller, Jonathan Paul, Theodore D Conliffe, Alexander R Vaccaro, Zach Broyer
CASE: We present a case of delayed osteonecrosis of the ilium. After receiving embolization and multiple orthopaedic procedures following a complex pelvic crush injury, the patient subsequently developed posterior pelvic pain and tenderness over the posterior superior iliac spine, along with pain on sacroiliac joint compression. Magnetic resonance imaging of the pelvis demonstrated a bone infarction in the left ilium adjacent to the sacroiliac joint. CONCLUSION: The symptoms from osteonecrosis of the ilium may simulate sacroiliitis or other conditions...
October 2017: JBJS Case Connector
Stacey M Cornelson, David Beavers, Allison Harvey, William Hogarth, Norman W Kettner
Objective: This report describes chiropractic management for 3 cases of inactive ankylosing spondylitis (AS). Clinical Features: A 25-year-old woman presented with chronic, mechanical neck pain and stiffness that was ultimately diagnosed as AS. A 23-year-old man presented with chronic low back and left hip pain that was diagnosed as AS. A 31-year-old man with low back pain presented with a known diagnosis of AS. Physical examination in 2 cases failed to identify systemic findings associated with AS...
December 2017: Journal of Chiropractic Medicine
Nilasha Ghosh, Eric M Ruderman
Current classification criteria for axial spondyloarthritis (axSpA) provide for the inclusion of patients with a wide range of presentations and manifestations. While not considered a formal subclassification, patients are often divided into radiographic or nonradiographic axSpA based on the presence or absence of radiographic sacroiliitis. This review will focus on nonradiographic axSpA and will discuss clinical manifestations of disease that distinguish, or in many cases do not distinguish, this entity from other individuals with axSpA...
December 22, 2017: Arthritis Research & Therapy
Anca Emanuela Muşetescu, Marius Florea, Mircea Cătălin ForŢofoiu, Ana Maria Bumbea, Andreea Daniela Tudorancea, Cristina Criveanu, Cristina Elena GofiŢă, Paulina Lucia Ciurea, Alexandru Ştefănescu, Ştefan Cristian Dinescu, Carmen Aurelia Mogoantă
In clinical practice and literature studies, the most common condition associated to streptococcal tonsillitis used to be acute rheumatic fever (ARF). Several publications in the late years report a more frequent and distinctive entity from ARF following β-hemolytic group A streptococcus infection in patients with post-infectious arthritis, that do not fulfill the modified Jones criteria, the so-called post-streptococcal reactive arthritis (PSRA). A distinctive pattern of clinical framing and biological profile in patients with PSRA following streptococcal tonsillitis is described, with a non-migratory, additive, recent onset (7-10 days) arthritis that affects small and large joints as well, with a bimodal peak of incidence at 8-14 and 21-37 years of age, with variate response to non-steroidal anti-inflammatory drugs and has a tendency for recurrence and persistence...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Danmin Wang, Zhiduo Hou, Yao Gong, Subiao Chen, Ling Lin, Zhengyu Xiao
OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed...
2017: PloS One
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