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https://www.readbyqxmd.com/read/29770362/study-of-anti-m%C3%A3-llerian-hormone-levels-in-patients-with-myotonic-dystrophy-type-1-preliminary-results
#1
Manuela Ergoli, Massimo Venditti, Raffaele Dotolo, Esther Picillo, Sergio Minucci, Luisa Politano
Myotonic dystrophy type 1 is a multisystemic disorder characterized by myotonia, muscle weakness and involvement of several organs and apparatus such as heart, lungs, eye, brain and endocrine system. Hypogonadism and reproductive abnormalities are frequently reported. A progressive testicular atrophy occurs in about 80% in the affected males leading to Leydig cell hyperproliferation and elevated basal follicle stimulating hormone (FSH) levels. Anti-Müllerian hormone (AMH) - a dimeric glycoprotein belonging to the super-family of transforming grow factor beta (TGF-beta) - is the earliest Sertoli cell hormone secreted in males and, together with inhibin B and FSH, is an important indicator of Sertoli cell function...
December 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29767392/a-novel-rabbit-model-for-benign-biliary-stricture-formation-and-the-effects-of-medication-infusions-on-stricture-formation
#2
Qin Yang, Junke Wang, Fei Liu, Wenjie Ma, Haijie Hu, Congdun Ran, Fuyu Li, Qiuwei Pan
BACKGROUND: Benign biliary stricture (BBS) is highly refractory. Currently, there is no effective strategy for prevention of BBS recurrence. The aim of this study is to establish a novel BBS rabbit model and to investigate the efficacy of biliary infusion with anti-proliferative medications for treating BBS. METHOD: A BBS model was established via surgical injury and biliary infection. The biliary infusion tube was inserted into the common bile duct via the stump of cystic duct after cholecystectomy...
May 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29755291/transcription-factor-co-expression-networks-of-adipose-rna-seq-data-reveal-regulatory-mechanisms-of-obesity
#3
Ruta Skinkyte-Juskiene, Lisette J A Kogelman, Haja N Kadarmideen
Background: Transcription Factors (TFs) control actuation of genes in the genome and are key mediators of complex processes such as obesity. Master Regulators (MRs) are the genes at the top of a regulation hierarchy which regulate other genes. Objective: To elucidate clusters of highly co-expressed TFs (modules), involved pathways, highly inter-connected TFs (hub-TFs) and MRs leading to obesity and leanness, using porcine model for human obesity. Methods: We identified 817 expressed TFs in RNA-Sequencing dataset representing extreme degrees of obesity (DO; lean, obese)...
May 2018: Current Genomics
https://www.readbyqxmd.com/read/29752880/the-clinical-relevance-of-fragile-histidine-triad-protein-fhit-in-patients-with-bladder-cancer
#4
Xiao-Ping Liu, Xiao-Hong Yin, Xin-Hui Yan, Xian-Tao Zeng, Xing-Huan Wang
BACKGROUND The present study aimed to investigate the clinical relevance of fragile histidine triad protein (FHIT) in patients with bladder cancer (BC). MATERIAL AND METHODS Three independent BC microarray studies were collected and reanalyzed. The expression of FHIT was evaluated between BC samples and normal bladder tissues. The correlation between the expression of FHIT and clinicopathological features was analyzed using the chi-square test. Log-rank based survival analysis was conducted to detect the survival significance of FHIT in patients with BC...
May 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29750874/hematological-findings-in-non-treated-and-gamma-irradiated-mice-deficient-for-mic-1-gdf15
#5
M Hofer, Z Hoferová, J Remšík, M Nováková, J Procházková, R Fedr, J Kohoutek, L Dušek, A Hampl, K Souček
Several members of the TGF-beta family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-beta family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29739329/thrombin-and-factor-xa-link-the-coagulation-system-with-liver-fibrosis
#6
Ameet Dhar, Fouzia Sadiq, Quentin M Anstee, Adam P Levene, Robert D Goldin, Mark R Thursz
BACKGROUND: Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent model of hepatic fibrosis. METHODS: HSC-LX2 cells were incubated with FXa and/or thrombin in cell culture, stained for αSMA and relative gene expression and gel contraction calculated...
May 8, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29725243/mirna-135b-contributes-to-triple-negative-breast-cancer-molecular-heterogeneity-different-expression-profile-in-basal-like-versus-non-basal-like-phenotypes
#7
Paolo Uva, Paolo Cossu-Rocca, Federica Loi, Giovanna Pira, Luciano Murgia, Sandra Orrù, Matteo Floris, Maria Rosaria Muroni, Francesca Sanges, Ciriaco Carru, Andrea Angius, Maria Rosaria De Miglio
The clinical and genetic heterogeneity of Triple Negative Breast Cancer (TNBC) and the lack of unambiguous molecular targets contribute to the inadequacy of current therapeutic options for these variants. MicroRNAs (miRNA) are a class of small highly conserved regulatory endogenous non-coding RNA, which can alter the expression of genes encoding proteins and may play a role in the dysregulation of cellular pathways. Our goal was to improve the knowledge of the molecular pathogenesis of TNBC subgroups analyzing the miRNA expression profile, and to identify new prognostic and predictive biomarkers...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29723239/analysis-of-the-microrna-signature-in-left-atrium-from-patients-with-valvular-heart-disease-reveals-their-implications-in-atrial-fibrillation
#8
Rosa Doñate Puertas, Audrey Jalabert, Emmanuelle Meugnier, Vanessa Euthine, Philippe Chevalier, Sophie Rome
BACKGROUND: Among the potential factors which may contribute to the development and perpetuation of atrial fibrillation, dysregulation of miRNAs has been suggested. Thus in this study, we have quantified the basal expressions of 662 mature human miRNAs in left atrium (LA) from patients undergoing cardiac surgery for valve repair, suffering or not from atrial fibrillation (AF) by using TaqMan® Low Density arrays (v2.0). RESULTS: Among the 299 miRNAs expressed in all patients, 42 miRNAs had altered basal expressions in patients with AF...
2018: PloS One
https://www.readbyqxmd.com/read/29718995/correction-inhibiting-tgf-beta-signaling-preserves-the-function-of-highly-activated-in-vitro-expanded-natural-killer-cells-in-aml-and-colon-cancer-models
#9
Folashade Otegbeye, Evelyn Ojo, Stephen Moreton, Nathan Mackowski, Dean A Lee, Marcos de Lima, David N Wald
[This corrects the article DOI: 10.1371/journal.pone.0191358.].
2018: PloS One
https://www.readbyqxmd.com/read/29707331/expression-of-tgf-beta-receptor-1-and-smads-in-the-tissues-of-primary-spontaneous-pneumothorax
#10
Xiaoyu Wang, Bin You, Shuo Chen, Wenqian Zhang, Bo Tian, Hui Li
Background: Primary spontaneous pneumothorax (PSP) is a common disease which is often caused by the rupture of bullae in the lungs. The underlying pathogenesis of PSP remains unclear. Some molecules may be involved in the development of PSP potentially. The aim of this study was to investigate the expression of TGF-beta receptor 1 (TβR1), Smad2, Smad3 and Smad4 in the resected bullae of patients with PSP. Methods: From May 2015 to May 2016, 34 patients with PSP underwent video-assisted thoracoscopic surgery (VATS) bullectomy...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29705848/how-to-monitor-the-neuroimmune-biological-response-in-patients-affected-by-immune-alteration-related-systemic-diseases
#11
Paolo Lissoni, Franco Rovelli, Luigi Vigorè, Giusy Messina, Arianna Lissoni, Giorgio Porro, Giuseppe Di Fede
The clinical management of patients affected by systemic diseases, including cancer and autoimmune diseases, is generally founded on the evaluation of the only markers related to the single disease rather than the biological immuno-inflammatory response of patients, despite the fundamental role of cytokine network in the pathogenesis of cancer and autoimmunity is well known. Cancer progression has appeared to be associated with a progressive decline in the blood levels of the main antitumor cytokines, including IL-2 and IL-12, in association with an increase in those of inflammatory cytokines, including IL-6, TNF-alpha, and IL-1-beta, and immunosuppressive cytokines, namely TGF-beta and IL-10...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29704139/anti-fibrogenic-potential-of-mesenchymal-stromal-cells-in-treating-fibrosis-in-crohn-s-disease
#12
Lei Lian, Qunsheng Huang, Longjuan Zhang, Huabo Qin, Xiaosheng He, Xin He, Jia Ke, Minghao Xie, Ping Lan
BACKGROUND: Intestinal fibrosis is a major complication of CD and may result in stricture formation leading to intestinal obstruction. MSCs play multiple roles in active CD and fibrosis-associated diseases. AIMS: This study was designed to investigate the role of MSCs in CD-associated intestinal fibrosis. METHODS: Intestinal fibrosis was induced over 7 weeks of enema with increasing doses of TNBS and assessed by Masson's trichrome staining...
April 27, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29702674/characterization-of-a-morphogenetic-furrow-specific-gal4-driver-in-the-developing-drosophila-eye
#13
Ankita Sarkar, Neha Gogia, Kevin Farley, Lydia Payton, Amit Singh
The ability to express a gene of interest in a spatio-temporal manner using Gal4-UAS system has allowed the use of Drosophila model to study various biological phenomenon. During Drosophila eye development, a synchronous wave of differentiation called Morphogenetic furrow (MF) initiates at the posterior margin resulting in differentiation of retinal neurons. This synchronous differentiation is also observed in the differentiating retina of vertebrates. Since MF is highly dynamic, it can serve as an excellent model to study patterning and differentiation...
2018: PloS One
https://www.readbyqxmd.com/read/29693588/relative-contribution-of-cellular-complement-inhibitors-cd59-cd46-and-cd55-to-parainfluenza-virus-5-inhibition-of-complement-mediated-neutralization
#14
Yujia Li, Griffith D Parks
The complement system is a part of the innate immune system that viruses need to face during infections. Many viruses incorporate cellular regulators of complement activation (RCA) to block complement pathways and our prior work has shown that Parainfluenza virus 5 (PIV5) incorporates CD55 and CD46 to delay complement-mediated neutralization. In this paper, we tested the role of a third individual RCA inhibitor CD59 in PIV5 interactions with complement pathways. Using a cell line engineered to express CD59, we show that small levels of functional CD59 are associated with progeny PIV5, which is capable of blocking assembly of the C5b-C9 membrane attack complex (MAC)...
April 25, 2018: Viruses
https://www.readbyqxmd.com/read/29666300/a-pan-cancer-landscape-of-interactions-between-solid-tumors-and-infiltrating-immune-cell-populations
#15
David Tamborero, Carlota Rubio-Perez, Ferran Muiños, Radhakrishnan Sabarinathan, Josep Maria Piulats, Aura Muntasell, Rodrigo Dienstmann, Nuria Lopez-Bigas, Abel Gonzalez-Perez
PURPOSE: Throughout their development tumors are challenged by the immune system and they acquire features to evade its surveillance. A systematic view of these traits which sheds light on how tumors respond to immunotherapies is still lacking. EXPERIMENTAL DESIGN: Here, we computed the relative abundance of an array of immune cell populations to measure the immune infiltration pattern of 9,174 tumors of 29 solid cancers. We then clustered tumors with similar infiltration pattern to define immune-phenotypes...
April 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29659324/montelukast-attenuates-radioactive-i131-induced-pulmonary-damage-on-rats
#16
Arif Osman Tokat, Aylin Akbulut, Deniz Billur, Gokhan Koca, Pinar Bayram, Serdar Kuru, Sezgin Karasu, Suheyla Aydogmus, Hüseyin Cakmak, Sengul Ozmert, Meliha Korkmaz
PURPOSE: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas, however, I131 also accumulates in non-thyroidal tissue, which may cause adverse effects and limit the I131 dose required for treatment. We hypothesized that montelukast, a known agent with anti-inflammatory and anti-oxidant properties, would ameliorate the radiation-induced histopathological characteristics such as pneumonitis and fibrosis in rat lungs after RAI...
April 16, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29659051/psa-alpha-2-macroglobulin-complex-is-enzymatically-active-in-the-serum-of-patients-with-advanced-prostate-cancer-and-can-degrade-circulating-peptide-hormones
#17
Maya B Kostova, William Nathaniel Brennen, David Lopez, Lizamma Anthony, Hao Wang, Elizabeth Platz, Samuel R Denmeade
BACKGROUND: Prostate cancer cells produce high levels of the serine protease Prostate-Specific Antigen (PSA). PSA is enzymatically active in the tumor microenvironment but is presumed to be enzymatically inactive in the blood due to complex formation with serum protease inhibitors α-1-antichymotrypsin and α-2-macroglobulin (A2M). PSA-A2M complexes cannot be measured by standard ELISA assays and are also rapidly cleared from the circulation. Thus the exact magnitude of PSA production by prostate cancer cells is not easily measured...
April 16, 2018: Prostate
https://www.readbyqxmd.com/read/29621540/tgf-beta-inhibits-expression-of-sp-a-sp-b-sp-c-but-not-sp-d-in-human-alveolar-type-ii-cells
#18
Kelly A Correll, Karen E Edeen, Rachel L Zemans, Elizabeth F Redente, Amanda Mikels-Vigdal, Robert J Mason
TGF beta is a multifunctional cytokine that regulates alveolar epithelial cells as well as immune cells and fibroblasts. TGF beta inhibits surfactant protein A, B and C expression in fetal human lung and can inhibit type II cell proliferation induced by FGF7 (KGF). However, little is known about direct effects of TGF beta on adult human type II cells. We cultured alveolar type II cells under air/liquid interface conditions to maintain their state of differentiation with or without TGF beta. TGF beta markedly decreased expression of SP-A, SP-B, SP-C, fatty acid synthase, and the phospholipid transporter ABCA3...
April 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29615416/the-drosophila-tgf-beta-activin-like-ligands-dawdle-and-myoglianin-appear-to-modulate-adult-lifespan-through-regulation-of-26s-proteasome-function-in-adult-muscle
#19
Shaughna Langerak, Myung-Jun Kim, Hannah Lamberg, Michael Godinez, Mackenzie Main, Lindsey Winslow, Michael B O'Connor, Changqi C Zhu
The Drosophila Activin signaling pathway employs at least three separate ligands, Activin-β (Actβ), Dawdle (Daw), and Myoglianin (Myo), to regulate several general aspects of fruit fly larval development including cell proliferation, neuronal remodeling, and metabolism. Here we provide experimental evidence indicating that both Daw and Myo are anti-ageing factors in adult fruit flies. Knockdown of Myo or Daw in adult fruit flies reduced mean lifespan, while overexpression of either ligand in adult muscle tissues but not in adipose tissues enhanced mean lifespan...
April 3, 2018: Biology Open
https://www.readbyqxmd.com/read/29581558/identification-of-urinary-activin-a-as-a-novel-biomarker-reflecting-the-severity-of-acute-kidney-injury
#20
Shunsuke Takahashi, Masao Nakasatomi, Yoshinori Takei, Hidekazu Ikeuchi, Toru Sakairi, Yoriaki Kaneko, Keiju Hiromura, Yoshihisa Nojima, Akito Maeshima
Acute kidney injury (AKI) is a common but complex condition that is associated with increased morbidity and mortality. In the present study, we examined whether urinary activin A, a member of the TGF-beta superfamily, is present in mice with ischemia-reperfusion injury and in humans with AKI, as well as its potential as a biomarker for AKI. Expression of activin A was markedly increased in ischemic mouse kidneys. In situ hybridization demonstrated that activin mRNA was expressed in tubular cells of ischemic kidneys but not of normal kidneys...
March 26, 2018: Scientific Reports
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