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intermittent fasting

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https://www.readbyqxmd.com/read/29659529/high-intensity-intermittent-exercise-increases-fat-oxidation-rate-and-reduces-postprandial-triglyceride-concentrations
#1
Tsung-Jen Yang, Ching-Lin Wu, Chih-Hui Chiu
(1) Background: This study investigated the effect of acute barehanded whole body high-intensity intermittent exercise (HIIE) and moderate intensity and continuous exercise (MICE) at the same quantity of energy expenditure on postprandial triglyceride (TG) concentrations. (2) Methods: Nine healthy males completed three trials (HIIE, MICE and control (CON)) in a random order separated by at least 14 days. After each intervention, the participants rested for 12 h and consumed a high-fat test meal on the next day...
April 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29652545/strategies-for-optimal-cardiovascular-aging
#2
Douglas R Seals, Vienna E Brunt, Matthew J Rossman
This review summarizes the opening keynote presentation overview of the American Physiological Society conference on Cardiovascular Aging: New Frontiers and Old Friends held in Westminster, CO, in August 2017. Age is the primary risk factor for cardiovascular diseases (CVD). Without effective intervention, increased numbers of older adults in the future will translate to greater prevalence of CVD and related disorders. Advancing age increases the risk of CVD partly via direct effects on the heart and through increases in blood pressure; however, much of the risk is mediated by arterial dysfunction, including large elastic artery stiffening and both macro- and micro-vascular endothelial dysfunction...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29642630/aging-and-intermittent-fasting-impact-on-transcriptional-regulation-and-physiological-responses-of-adult-drosophila-neuronal-and-muscle-tissues
#3
Sharon Zhang, Eric P Ratliff, Brandon Molina, Nadja El-Mecharrafie, Jessica Mastroianni, Roxanne W Kotzebue, Madhulika Achal, Ruth E Mauntz, Arysa Gonzalez, Ayeh Barekat, William A Bray, Andrew M Macias, Daniel Daugherty, Greg L Harris, Robert A Edwards, Kim D Finley
The progressive decline of the nervous system, including protein aggregate formation, reflects the subtle dysregulation of multiple functional pathways. Our previous work has shown intermittent fasting (IF) enhances longevity, maintains adult behaviors and reduces aggregates, in part, by promoting autophagic function in the aging Drosophila brain. To clarify the impact that IF-treatment has upon aging, we used high throughput RNA-sequencing technology to examine the changing transcriptome in adult Drosophila tissues...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29602178/ethanol-exposure-history-and-alcoholic-reward-differentially-alter-dopamine-release-in-the-nucleus-accumbens-to-a-reward-predictive-cue
#4
Amanda M Fiorenza, Tatiana A Shnitko, Kaitlin M Sullivan, Sudheer R Vemuru, Alexander Gomez-A, Julie Y Esaki, Charlotte A Boettiger, Claudio Da Cunha, Donita L Robinson
BACKGROUND: Conditioned stimuli (CS) that predict reward delivery acquire the ability to induce phasic dopamine release in the nucleus accumbens. This dopamine release may facilitate conditioned approach behavior, which often manifests as approach to the site of reward delivery (called 'goal-tracking') or to the CS itself (called 'sign-tracking'). Previous research has linked sign-tracking in particular to impulsivity and drug self-administration, and addictive drugs may promote the expression of sign-tracking...
March 30, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29587874/the-effects-of-different-forms-of-daily-exercise-on-metabolic-function-following-short-term-overfeeding-and-reduced-physical-activity-in-healthy-young-men-study-protocol-for-a-randomised-controlled-trial
#5
Jean-Philippe Walhin, Yung-Chih Chen, Aaron Hengist, James Bilzon, James A Betts, Dylan Thompson
BACKGROUND: Short-term overfeeding combined with reduced physical activity impairs metabolic function and alters the expression of key genes within adipose tissue. We have shown that daily vigorous-intensity running can prevent these changes independent of any net effect on energy imbalance. However, which type, intensity and/or duration of exercise best achieves these benefits remains to be ascertained. METHODS/DESIGN: Forty-eight healthy young men will be recruited and randomly allocated to one of four experimental conditions for 1 week: (1) to ingest 50% more energy than normal by over-consuming their habitual diet whilst simultaneously restricting their physical activity below 4000 steps day-1 (i...
March 27, 2018: Trials
https://www.readbyqxmd.com/read/29576352/impact-of-intermittent-fasting-on-the-lipid-profile-assessment-associated-with-diet-and-weight-loss
#6
REVIEW
Heitor O Santos, Rodrigo C O Macedo
Intermittent fasting, whose proposed benefits include the improvement of lipid profile and the body weight loss, has gained considerable scientific and popular repercussion. This review aimed to consolidate studies that analyzed the lipid profile in humans before and after intermittent fasting period through a detailed review; and to propose the physiological mechanism, considering the diet and the body weight loss. Normocaloric and hypocaloric intermittent fasting may be a dietary method to aid in the improvement of the lipid profile in healthy, obese and dyslipidemic men and women by reducing total cholesterol, LDL, triglycerides and increasing HDL levels...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29568813/hypoglycemia-in-a-patient-with-a-polyhormonal-pancreatic-neuroendocrine-tumor-with-evidence-of-endocrine-progenitors
#7
Zachary B Simons, Rachel C Morgan, Laurel Rose, Jennifer B Nelson, Sarah A Tersey, Raghavendra G Mirmira
A 55-year-old woman with a large polyhormonal neuroendocrine tumor with unusual pathology is described. The patient presented with intermittent neuroglycopenic symptoms between more protracted asymptomatic periods occurring over the preceding 4 years. During a diagnostic 72-hour inpatient fast, she exhibited hypoglycemia at 70 hours after initiation. On computed tomography scan, a 6-cm mass was identified at the pancreatic head. The patient underwent a pylorus-preserving pancreaticoduodenectomy, and pathology was positive for cells staining for pancreatic polypeptide, insulin, and occasional double hormone (insulin plus pancreatic polypeptide)-positive cells...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29560909/subgenual-anterior-cingulate-medial-orbitofrontal-functional-connectivity-in-medication-resistant-major-depression-a-neurobiological-marker-for-accelerated-intermittent-theta-burst-stimulation-treatment
#8
Chris Baeken, Romain Duprat, Guo-Rong Wu, Rudi De Raedt, Kees van Heeringen
BACKGROUND: Accelerated repetitive transcranial magnetic stimulation paradigms have been shown to result in fast decreases in depressive symptoms and suicidal ideation. Although the subgenual anterior cingulate cortex (sgACC) region has been put forward as a possible biological marker, so far, no studies evaluated the clinical effects of accelerated intermittent theta burst stimulation (aiTBS) on sgACC functional connectivity (FC). METHODS: Fifty patients with treatment-resistant depression were enrolled in this registered randomized double-blind sham-controlled crossover aiTBS treatment study...
October 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29550833/a-case-of-lown-ganong-levine-syndrome-due-to-an-accessory-pathway-of-james-fibers-or-enhanced-atrioventricular-nodal-conduction-eavnc
#9
Juanita Hunter, Emmanouil Tsounias, John Cogan, Ming-Lon Young
BACKGROUND Lown-Ganong-Levine syndrome, includes a short PR interval, normal QRS complex, and paroxysmal tachycardia. The pathophysiology of this syndrome includes an accessory pathway connecting the atria and the atrioventricular (AV) node (James fiber), or between the atria and the His bundle (Brechenmacher fiber). Similar features are seen in enhanced atrioventricular nodal conduction (EAVNC), with the underlying pathophysiology due to a fast pathway to the AV node, and with the diagnosis requiring specific electrophysiologic criteria...
March 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29534545/intermittent-fasting-with-or-without-exercise-prevents-weight-gain-and-improves-lipids-in-diet-induced-obese-mice
#10
Robin A Wilson, William Deasy, Christos G Stathis, Alan Hayes, Matthew B Cooke
Intermittent fasting (IF) and high intensity interval training (HIIT) are effective lifestyle interventions for improving body composition and overall health. However, the long-term effects of IF and potential synergistic effects of combining IF with exercise are unclear. The purpose of the study was to investigate the long-term effects of IF, with or without HIIT, on body composition and markers of metabolic health in diet-induced obese mice. In a randosmised, controlled design, 8-week-old C57BL/6 mice (males ( n = 39) and females ( n = 49)) were fed a high fat (HF) and sugar (S) water diet (30% ( w / v )) for 24-weeks but were separated into five groups at 12-weeks: (1) 'obese' baseline control (OBC); (2) no intervention (CON); (3) intermittent fasting (IF); (4) high intensity intermittent exercise (HIIT) and (5) combination of dietary and exercise intervention (IF + HIIT)...
March 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29510748/preventing-mutant-huntingtin-proteolysis-and-intermittent-fasting-promote-autophagy-in-models-of-huntington-disease
#11
Dagmar E Ehrnhoefer, Dale D O Martin, Mandi E Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S Caron, Niels H Skotte, Yen T N Nguyen, Kuljeet Vaid, Amber L Southwell, Sabine Engemann, Sonia Franciosi, Michael R Hayden
Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo loading during selective autophagy. Here we show that the expression of mHTT resistant to proteolysis at the caspase cleavage site D586 (C6R mHTT) increases autophagy, which may be due to its increased binding to the autophagy adapter p62. This is accompanied by faster degradation of C6R mHTT in vitro and a lack of mHTT accumulation the C6R mouse model with age...
March 6, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29508693/intermittent-v-continuous-energy-restriction-differential-effects-on-postprandial-glucose-and-lipid-metabolism-following-matched-weight-loss-in-overweight-obese-participants
#12
Rona Antoni, Kelly L Johnston, Adam L Collins, M Denise Robertson
The intermittent energy restriction (IER) approach to weight loss involves short periods of substantial (>70 %) energy restriction (ER) interspersed with normal eating. Studies to date comparing IER to continuous energy restriction (CER) have predominantly measured fasting indices of cardiometabolic risk. This study aimed to compare the effects of IER and CER on postprandial glucose and lipid metabolism following matched weight loss. In all, twenty-seven (thirteen male) overweight/obese participants (46 (sem 3) years, 30·1 (sem 1·0) kg/m2) who were randomised to either an IER intervention (2638 kJ for 2 d/week with an overall ER of 22 (sem 0·3) %, n 15) or a CER intervention (2510 kJ below requirements with overall ER of 23 (sem 0·8) %) completed the study...
March 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29504768/pulse-packet-stochastic-model-for-gastric-emptying-in-the-fasted-state-a-physiological-approach
#13
Arjang Talattof, Gordon L Amidon
Fasted-state gastrointestinal (GI) fluid transit is typically represented as a first-order, deterministic process (averaged and viewed as a continuous approximation). It is, however, most likely a discrete process involving fluid packets interrupted by variable time periods of little to no fluid emptying. In this report we present a physiologically based pulsed-packet gastric fluid emptying model and evaluate it with respect to recent gastrointestinal fluid volume emptying results, published gastric emptying of various dosage forms, and gastric fluid emptying as a function of GI motility...
March 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29501784/impact-of-prolonged-fasting-on-the-risk-of-calcium-phosphate-precipitation-in-the-urine-calcium-phosphate-lithogenesis-during-prolonged-fasting-in-healthy-cohort
#14
Mohammad A Shafiee, Mehdi Aarabi, Pouyan Shaker, Amir M Ghafarian, Pouyan Chamanian, Mitchell L Halperin
PURPOSE: Intermittent fasting and curtailing water intake for extended periods of time was likely to be common in Paleolithic times. Nowadays, it occurs for religious and dietary reasons. This restriction in intake should cause a decrease in urine flow rate (UFR), while raising the concentrations of certain substances in the urine to the point of precipitation. In this study, we measured the risk of calcium phosphate (CaHPO4) precipitation following 18 hours of food and water deprivation...
March 1, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29499664/the-fast-exodrift-after-the-first-surgical-treatment-of-exotropia-and-its-correlation-with-surgical-outcome-of-second-surgery
#15
Won Jae Kim, Myung Mi Kim
BACKGROUND: To compare the rate of exodrift after a second surgery for recurrent exotropia, in patients grouped to fast versus slow exodrift after their first surgery. To determine whether there is a correlation with surgical outcome, and to evaluate the factors associated with fast exodrift. METHODS: Patients with recurrent intermittent exotropia, who underwent contralateral lateral rectus recession and medial rectus resection as the second surgery and were followed up for 24 months postoperatively between January 1991 and January 2013, were reviewed retrospectively...
March 2, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29498225/the-relationship-between-increased-oxidative-stress-and-visual-field-defect-progression-in-glaucoma-patients-with-sleep-apnoea-syndrome
#16
Erika Yamada, Noriko Himori, Hiroshi Kunikata, Kazuko Omodaka, Hiromasa Ogawa, Masakazu Ichinose, Toru Nakazawa
PURPOSE: Sleep apnoea syndrome (SAS) is often associated with glaucoma, and intermittent hypoxia, present in SAS, can contribute to glaucoma pathogenesis. However, the relationships between SAS, high systemic oxidative stress and the speed of glaucoma progression are unclear. Thus, we investigated these relationships in glaucoma patients with and without SAS. METHODS: Peripheral blood samples were collected from 166 eyes of 166 Japanese patients: 42 controls, 109 open-angle glaucoma (OAG) patients without SAS and 15 OAG patients with SAS...
March 2, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29485326/the-effect-of-10-days-of-intermittent-fasting-on-wingate-anaerobic-power-and-prolonged-high-intensity-time-to-exhaustion-cycling-performance
#17
Mohamed Nashrudin Bin Naharudin, Ashril Yusof
Many physically active individuals have undertaken intermittent fasting to reduce their daily caloric intake. However, abstaining from meals for a specific length of time may lead to the acute disturbance of highly carbohydrate-dependent exercise performance. The purpose of this study was to observe the effect of 10 days of intermittent fasting on high-intensity type exercises, Wingate anaerobic (WT) and prolonged high-intensity time-to-exhaustion (HIT) cycling test. Twenty participants were randomised into an intermittent fasting (FAS) and a control group (CON)...
February 27, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29469013/intermittent-food-restriction-in-female-rats-induces-srebp-high-expression-in-hypothalamus-and-immediately-postfasting-hyperphagia
#18
Mariana Alejandra Rosas Fernández, Carlos Marcelo Concha Vilca, Leandro Oliveira Batista, Viviane Wagner Ramos, Leonardo Paes Cinelli, Kelse Tibau de Albuquerque
OBJECTIVE: We investigated the effect of intermittent food restriction (IFR) cycles on hypothalamic expression of lipogenic proteins and induction of overeating. METHODS: Female Wistar rats were distributed in three groups: free access to feed (control, C), 2 d feed restriction at 50% of C intake followed by 3 d (restricted 3, R3) or 5 d (restricted 5, R5) ad libitum feeding. After 6 wk, the rats were submitted to euthanasia and collected the hypothalamus and blood...
December 6, 2017: Nutrition
https://www.readbyqxmd.com/read/29467607/understanding-the-generation-of-network-bursts-by-adaptive-oscillatory-neurons
#19
Tanguy Fardet, Mathieu Ballandras, Samuel Bottani, Stéphane Métens, Pascal Monceau
Experimental and numerical studies have revealed that isolated populations of oscillatory neurons can spontaneously synchronize and generate periodic bursts involving the whole network. Such a behavior has notably been observed for cultured neurons in rodent's cortex or hippocampus. We show here that a sufficient condition for this network bursting is the presence of an excitatory population of oscillatory neurons which displays spike-driven adaptation. We provide an analytic model to analyze network bursts generated by coupled adaptive exponential integrate-and-fire neurons...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29450135/development-of-a-specific-index-to-detect-malnutrition-in-athletes-validity-in-weight-class-or-intermittent-fasted-athletes
#20
François D Desgorces, Christophe Moinard, Mounir Chennaoui, Jean-François Toussaint, Cyril Petibois, Philippe Noirez
Fasted or weight-category athletes manage their training under strict diet conditions that could impair the stress-recovery balance and result in acute or chronic fatigue. However, to date, no validated biomarker are available to quantify this phenomena. The aim of this study was to assess the validity of a specific index combining plasma albumin and weight change to detect nutrition-related risks of fatigue increase and under-performance in athletes experiencing particular nutritional conditions. An athlete's nutrition risk index (ANRI) equation, based on data from lightweight and heavyweight rowers, was developed using relationship between plasma albumin concentrations combined to weight changes with sport performance and overtraining scores and was tested by odds ratio for failure...
June 2017: Biochimie open
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