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https://www.readbyqxmd.com/read/28808490/the-influence-of-intermittent-fasting-on-the-circadian-pattern-of-melatonin-while-controlling-for-caloric-intake-energy-expenditure-light-exposure-and-sleep-schedules-a-preliminary-report
#1
Aljohara S Almeneessier, Ahmed S Bahammam, Munir M Sharif, Salman A Bahammam, Samar Z Nashwan, Seithikurippu R Pandi Perumal, Daniel P Cardinali, Mohammad Alzoghaibi
AIMS: We hypothesized that if we control for food composition, caloric intake, light exposure, sleep schedule, and exercise, intermittent fasting would not influence the circadian pattern of melatonin. Therefore, we designed this study to assess the effect of intermittent fasting on the circadian pattern of melatonin. METHODS: Eight healthy volunteers with a mean age of 26.6 ± 4.9 years and body mass index of 23.7 ± 3.5 kg/m(2) reported to the Sleep Disorders Center (the laboratory) on four occasions: (1) adaptation, (2) 4 weeks before Ramadan while performing Islamic intermittent fasting for 1 week (fasting outside Ramadan [FOR]), (3) 1 week before Ramadan (nonfasting baseline [BL]), and (4) during the 2(nd) week of Ramadan while fasting (Ramadan)...
July 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28797281/the-efficacy-of-transcutaneous-electrical-nerve-stimulation-on-the-improvement-of-walking-distance-in-patients-with-peripheral-arterial-disease-with-intermittent-claudication-study-protocol-for-a-randomised-controlled-trial-the-tens-pad-study
#2
Florent Besnier, Jean-Michel Sénard, Vincent Grémeaux, Mélanie Riédel, Damien Garrigues, Thibaut Guiraud, Marc Labrunée
BACKGROUND: In patients with peripheral arterial disease (PAD), walking improvements are often limited by early pain onset due to vascular claudication. It would thus appear interesting to develop noninvasive therapeutic strategies, such as transcutaneous electrical nerve stimulation (TENS), to improve the participation of PAD patients in rehabilitation programmes, and thus improve their quality of life. Our team recently tested the efficacy of a single 45-min session of 10-Hz TENS prior to walking...
August 10, 2017: Trials
https://www.readbyqxmd.com/read/28795793/an-unprecedented-case-a-low-specific-surface-area-anatase-n-doped-carbon-nanocomposite-derived-from-a-new-single-source-precursor-affords-fast-and-stable-lithium-storage
#3
Man Gao, Kaixiang Zou, Yuanfu Deng, Zhenxia Zhao, Yingwei Li, Guohua Chen
A nanocomposite of ultrafine anatase nanoparticles (<5 nm) embedded N-doped carbon (TiO2-NPs/NC) with a relatively low specific surface area was successfully synthesized by in situ pyrolysis of a new and cheap single source precursor of (H2en)3[Ti4(O2)4(Hcit)2(cit)2]·12H2O (en = ethylenediamine and H4cit = citric acid) under 550 °C and an inert atmosphere. The precursor in crystalline state was isolated from an aqueous solution containing of titanium butoxide, citric acid, hydrogen peroxide, and ethylenediamine and was characterized...
August 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28791787/is-two-days-of-intermittent-energy-restriction-per-week-a-feasible-weight-loss-approach-in-obese-males-a-randomised-pilot-study
#4
Marguerite Conley, Lauren Le Fevre, Cilla Haywood, Joseph Proietto
AIM: The 5:2 diet (two non-consecutive days of 2460 KJ (600 calories) and 5 days of ad libitum eating per week) is becoming increasingly popular. This pilot study aimed to determine whether the 5:2 diet can achieve ≥5% weight loss and greater improvements in weight and biochemical markers than a standard energy-restricted diet (SERD) in obese male war veterans. METHODS: A total of 24 participants were randomised to consume either the 5:2 diet or a SERD (2050 KJ (500 calorie) reduction per day) for 6 months...
August 9, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28770464/long-term-follow-up-in-a-girl-with-cystic-fibrosis-and-diabetes-since-the-first-year-of-life
#5
Valentina Fattorusso, Alida Casale, Valeria Raia, Enza Mozzillo, Adriana Franzese
Diabetes mellitus is the most common comorbidity in cystic fibrosis (CF). Recently, more attention has been paid to early glucose metabolism derangements (GMDs). The subject of this report is a female patient, affected by CF since 3 months of age. She presented with intermittent diabetes during early childhood. At the age of 10 years, oral glucose tolerance test (OGTT) was performed and showed glucose intolerance (IGT) status; glargine insulin therapy was started. At the age of 13 years, CF-related diabetes with fasting hyperglycemia occurred, so rapid insulin at meals was added...
August 2, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28761067/every-other-day-feeding-extends-lifespan-but-fails-to-delay-many-symptoms-of-aging-in-mice
#6
Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S Henzel, Sabine M Hölter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L Pearson, Ildiko Racz, Birgit Rathkolb, Devon P Ryan, Susanne Schröder, Irina Treise, Raffi Bekeredjian, Dirk H Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Dan Ehninger
Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28758418/intermittent-hypoxia-training-in-prediabetes-patients-beneficial-effects-on-glucose-homeostasis-hypoxia-tolerance-and-gene-expression
#7
Tetiana V Serebrovska, Alla G Portnychenko, Tetiana I Drevytska, Vladimir I Portnichenko, Lei Xi, Egor Egorov, Anna V Gavalko, Svitlana Naskalova, Valentina Chizhova, Valeriy B Shatylo
The present study aimed at examining beneficial effects of intermittent hypoxia training (IHT) under prediabetic conditions. We investigate the effects of three-week IHT on blood glucose level, tolerance to acute hypoxia, and leukocyte mRNA expression of hypoxia inducible factor 1α (HIF-1α) and its target genes, i.e. insulin receptor, facilitated glucose transporter-solute carrier family-2, and potassium voltage-gated channel subfamily J. Seven healthy and 11 prediabetic men and women (44-70 years of age) were examined before, next day and one month after three-week IHT (3 sessions per week, each session consisting 4 cycles of 5-min 12% O2 and 5-min room air breathing)...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28747336/an-innovative-intermittent-hypoxia-model-in-cell-cultures-allowing-fast-po2-oscillations-with-minimal-gas-consumption
#8
Mélanie Minoves, Jessica Morand, Frédéric Perriot, Morgane Chatard, Brigitte Gonthier, Emeline Lemarié, Jean-Baptiste Menut, Jan Polak, Jean-Louis Pepin, Diane Godin-Ribuot, Anne Briancon-Marjollet
Performing hypoxia-reoxygenation cycles in cell culture with a cycle duration accurately reflecting what occurs in obstructive sleep apnea (OSA) patients is a difficult but crucial technical challenge. Our goal was to develop a novel device to expose multiple cell culture dishes to intermittent hypoxia (IH) cycles relevant to OSA with limited gas consumption. With gas flows as low as 200 mL/min, our combination of plate holders with gas-permeable cultureware generates rapid normoxia-hypoxia cycles. Cycles alternating 1 minute at 20% O2 followed by 1 minute at 2% O2 result in pO2 values ranging from 124 to 44mmHg...
July 26, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28735949/hip-flexor-muscle-dysfunction-during-walking-at-self-selected-and-fast-speed-in-patients-with-aortoiliac-peripheral-arterial-disease
#9
COMPARATIVE STUDY
Takaaki Kakihana, Osamu Ito, Yusuke Sekiguchi, Daisuke Ito, Hitoshi Goto, Daijirou Akamatsu, Yasuharu Matsumoto, Masahiro Kohzuki
OBJECTIVE: Intermittent claudication aggravates physical function and is associated with an increased risk of death in patients with peripheral arterial disease (PAD). Previous studies on kinetic parameters (joint moment and power) of lower limbs in these patients have largely focused on the decline in the ankle plantar flexor moment and power at self-selected (SS) walking speed, which may not be an optimal condition to induce claudication pain. In the present study, we investigated the abnormalities in joint kinetic parameters in patients with PAD at both SS and at fast walking speeds...
August 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28735644/fasting-as-possible-complementary-approach-for-polycystic-ovary-syndrome-hope-or-hype
#10
Benito Chiofalo, Antonio Simone Laganà, Vittorio Palmara, Roberta Granese, Giacomo Corrado, Emanuela Mancini, Salvatore Giovanni Vitale, Helena Ban Frangež, Eda Vrtačnik-Bokal, Onofrio Triolo
Polycystic ovary syndrome (PCOS) is a common endocrine system disorder among women of reproductive age. In several cases, PCOS women show infertility or subfertility and other metabolic alteration, such as insulin resistance (InsR), dyslipidaemia, hyperinsulinemia and obesity. Despite the aetiology of the syndrome is still far from be elucidated, it could be considered the result of concurrent endocrine modifications, lifestyle factors and genetic background. In particular, accumulating evidence suggests that InsR and compensatory hyperinsulinemia play a pivotal pathogenic role in the hyperandrogenism of many PCOS phenotypes, which in turn have a clear detrimental effect on chronic anovulation...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28724042/hyperglycemia-in-critical-patients-determinants-of-insulin-dose-choice
#11
Aline Klitzke Paliosa, Cassiano Teixeira, Regis Goulart Rosa, Carine Raquel Blatt
Objective: To identify factors that can determine the choice of intermittent subcutaneous regular insulin dose in critically ill patients with hyperglycemia. Method: Cross-sectional study in a general adult ICU with 26 beds, data collected between September and October 2014. The variables analyzed were: sex, age, previous diagnosis of diabetes mellitus, use of corticosteroids, use of lactulose, sepsis, fasting, enteral nutrition, use of dextrose 5% in water, NPH insulin prescription and blood glucose level...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28715993/metabolic-effects-of-intermittent-fasting
#12
Ruth E Patterson, Dorothy D Sears
The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms "intermittent fasting," "fasting," "time-restricted feeding," and "food timing." Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human health...
July 17, 2017: Annual Review of Nutrition
https://www.readbyqxmd.com/read/28705217/monitoring-clinical-and-microbiological-evolution-of-a-cystic-fibrosis-patient-over-26%C3%A2-years-experience-of-a-brazilian-cf-centre
#13
Cassiana da Costa Ferreira Leite, Tania Wrobel Folescu, Mônica de Cássia Firmida, Renata Wrobel Folescu Cohen, Robson Souza Leão, Flávia Alvim Dutra de Freitas, Rodolpho Mattos Albano, Claudia Henrique da Costa, Elizabeth Andrade Marques
BACKGROUND: Burkholderia cepacia complex is a group of opportunistic pathogens in cystic fibrosis (CF) patients believed to be associated with poor prognosis and patient-to-patient transmissibility. Little is known about clinical outcomes after B. vietnamiensis chronic colonization/infection. CASE PRESENTATION: A 33 yo male patient had diagnosis of CF by 7 yo, after recurrent pneumonia during infancy and lobectomy (left upper lobe) at 6 yo. Burkholderia cepacia complex (Bcc) was first isolated by 13 yo, and the patient fulfilled the criteria for chronic colonization by 15 yo...
July 14, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28673080/enteral-nutrition-for-preterm-infants-by-bolus-or-continuous-an-update
#14
Valentina Bozzetti, Paolo E Tagliabue
Optimization of nutritional management of preterm infants is crucial for achievement of their long-term health. Enteral nutrition is preferred to total parenteral nutrition (TPN) because the former avoids complications related to vascular catheterization, sepsis, adverse effects of TPN, and fasting. Due to the lack of ability of preterm infants to coordinate suckling, swallowing, and breathing, tube feeding is necessary for most infants less than 1500 g to ensure sufficient feeding tolerance, to support optimal growth and to reduce the risk of aspiration...
June 28, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/28644979/intraoperative-fast-ripples-independently-predict-postsurgical-epilepsy-outcome-comparison-with-other-electrocorticographic-phenomena
#15
Shaun A Hussain, Gary W Mathern, Phoebe Hung, Julius Weng, Raman Sankar, Joyce Y Wu
In the surgical management of epilepsy, the resection of cortex exhibiting interictal fast ripples (250-500Hz) on electrocorticography has been linked to postoperative seizure-freedom. Although fast ripples appear to accurately identify the epileptogenic zone-the minimum tissue that must be removed at surgery to achieve seizure-freedom-it has not been established that fast ripples are a superior biomarker in comparison with multimodal presurgical neuroimaging and other electrocorticography abnormalities. Hence, in the prediction of postoperative seizure-freedom, we compared the value of fast ripples with other intraoperative electocorticography abnormalities including focal slowing, paroxysmal fast activity, intermittent spike discharges, continuous epileptiform discharges, focal attenuation, and intraoperative seizures, as well as complete resection of the lesion defined by MRI and other neuroimaging...
June 16, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28604365/avalanche-criticality-in-thermal-driven-martensitic-transitions-the-asymmetry-of-the-forward-and-reverse-transitions-in-shape-memory-materials
#16
Antoni Planes, Eduard Vives
Martensitic transitions take place intermittently as a sequence of avalanches which are accompanied by the emission of acoustic waves. The study of this acoustic emission (AE) reveals the scale-free nature of the avalanches. In a number of shape memory materials undergoing a martensitic transition it has been found that, in spite of relatively low hysteresis, the dynamics of forward and reverse transitions are different, which may explain the fact that the AE activity is different in both forward and reverse transitions...
August 23, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28603716/optimizing-nutrition-in-preterm-low-birth-weight-infants-consensus-summary
#17
REVIEW
R Kishore Kumar, Atul Singhal, Umesh Vaidya, Saswata Banerjee, Fahmina Anwar, Shashidhar Rao
Preterm birth survivors are at a higher risk of growth and developmental disabilities compared to their term counterparts. Development of strategies to lower the complications of preterm birth forms the rising need of the hour. Appropriate nutrition is essential for the growth and development of preterm infants. Early administration of optimal nutrition to preterm birth survivors lowers the risk of adverse health outcomes and improves cognition in adulthood. A group of neonatologists, pediatricians, and nutrition experts convened to discuss and frame evidence-based recommendations for optimizing nutrition in preterm low birth weight (LBW) infants...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28590737/reagent-free-quantification-of-aqueous-free-chlorine-via-electrical-readout-of-colorimetrically-functionalized-pencil-lines
#18
Amirmasoud Mohtasebi, Andrew D Broomfield, Tanzina Chowdhury, P Ravi Selvaganapathy, Peter Kruse
Colorimetric methods are commonly used to quantify free chlorine in drinking water. However, these methods are not suitable for reagent-free, continuous, and autonomous applications. Here, we demonstrate how functionalization of a pencil-drawn film with phenyl-capped aniline tetramer (PCAT) can be used for quantitative electric readout of free chlorine concentrations. The functionalized film can be implemented in a simple fluidic device for continuous sensing of aqueous free chlorine concentrations. The sensor is selective to free chlorine and can undergo a reagent-free reset for further measurements...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28541218/fast-post-processing-pipeline-for-optical-projection-tomography
#19
Xiaoqin Tang, Dennis M van der Zwaan, Alan Zammit, Kristian F D Rietveld, Fons J Verbeek
To improve the effectiveness and efficiency of optical projection tomography (OPT) 3-D reconstruction, we present a fast post-processing pipeline, including cropping, background subtraction, center of rotation (COR) correction, and 3-D reconstruction. Regarding to the COR correction, a novel algorithm based on interest point detection of sinogram is proposed by considering the principle of OPT imaging. Instead of locating the COR on single sinogram, we select equally spaced sinograms in the detected full range of specimen to make the located COR more convincing...
July 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28541017/extracranial-internal-carotid-artery-calcium-volume-measurement-using-computer-tomography
#20
Hediyeh Baradaran, Chuen R Ng, Ajay Gupta, Norliza M Noor, Khalid W Al-Dasuqi, Edward E Mtui, Omar M Rijal, Argiris Giannopoulos, Andrew Nicolaides, John R Laird, Luca Saba, Jasjit S Suri
BACKGROUND: The extent of calcium volume in the carotid arteries of contrast-based Computer Tomography (CT) is a valuable indicator of stroke risk. This study presents an automated, simple and fast calcium volume computation system. Since the high contrast agent can sometimes obscure the presence of calcium in the CT slices, it is therefore necessary to identify these slices before the corrected volume can be estimated. METHODS: The system typically consists of segmenting the calcium region from the CT scan into slices based on Hounsfield Unit-based threshold, and subsequently computing the summation of the calcium areas in each slice...
May 24, 2017: International Angiology: a Journal of the International Union of Angiology
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