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intermittent fasting

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https://www.readbyqxmd.com/read/29018355/criterion-validity-of-commercially-available-physical-activity-tracker-to-estimate-step-count-covered-distance-and-energy-expenditure-during-sports-conditions
#1
Yvonne Wahl, Peter Düking, Anna Droszez, Patrick Wahl, Joachim Mester
Background: In the past years, there was an increasing development of physical activity tracker (Wearables). For recreational people, testing of these devices under walking or light jogging conditions might be sufficient. For (elite) athletes, however, scientific trustworthiness needs to be given for a broad spectrum of velocities or even fast changes in velocities reflecting the demands of the sport. Therefore, the aim was to evaluate the validity of eleven Wearables for monitoring step count, covered distance and energy expenditure (EE) under laboratory conditions with different constant and varying velocities...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28978420/fasting-the-microbiota-to-improve-metabolism
#2
Joel T Haas, Bart Staels
While intermittent or periodic fasting provides a variety of favorable health benefits, the molecular mediators of these effects are poorly understood. In this issue of Cell Metabolism, Li and colleagues (2017) highlight the role of gut microbiota in mediating benefits of intermittent fasting through activation of adipose tissue beiging.
October 3, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28970945/intermittent-fasting-could-ameliorate-cognitive-function-against-distress-by-regulation-of-inflammatory-response-pathway
#3
Marjan Shojaie, Farzane Ghanbari, Nasrin Shojaie
Undesirable and desirable effects of stressors on the body are assigned to distress and eustress, respectively. Immune system and brain are the most susceptible parts to stressful conditions, whereas long-lasting alterations in putative immune proteins involved in tension such as corticosterone (CORT), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α) can impact learning and memory. Intermittent fasting (IF) is a repeated regular cycle of dietary restriction with well-known beneficial properties on the body...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28955681/recent-updates-of-the-diagnosis-and-prevention-of-venous-thromboembolism-in-patients-with-a-hip-fracture
#4
REVIEW
Won Chul Shin, Sang Min Lee, Kuen Tak Suh
Venous thromboembolism (VTE) is a potentially fatal complication that is relatively common after hip surgery. Since patients with a hip fracture have a higher risk of preoperative VTE due to an inability to ambulate after injury and aggravation of underlying age-related conditions, it may be difficult to effectively prevent VTE using only conventional approaches. Very few studies have been published reporting on the prevalence and prevention of VTE in patients with a hip fracture compared to those with hip arthroplasty...
September 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28955126/intermittent-fasting-prompted-recovery-from-dextran-sulfate-sodium-induced-colitis-in-mice
#5
Toshihiko Okada, Takeshi Otsubo, Teruki Hagiwara, Fumika Inazuka, Eiko Kobayashi, Shinji Fukuda, Takuya Inoue, Kazuhide Higuchi, Yuki I Kawamura, Taeko Dohi
Fasting-refeeding in mice induces transient hyperproliferation of colonic epithelial cells, which is dependent on the lactate produced as a metabolite of commensal bacteria. We attempted to manipulate colonic epithelial cell turnover with intermittent fasting to prompt recovery from acute colitis. Acute colitis was induced in C57BL/6 mice by administration of dextran sulfate sodium in the drinking water for 5 days. From day 6, mice were fasted for 36 h and refed normal bait, glucose powder, or lactylated high-amylose starch...
September 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28945141/professional-flash-continuous-glucose-monitoring-as-a-supplement-to-a1c-in-primary-care
#6
Irl B Hirsch
Decreasing glycated hemoglobin (A1C) is the primary goal of current diabetes management due to intervention studies in type 1 and type 2 diabetes associating levels <7.0% (53 mmol/mol) with lower complication risk. Strategic self-monitoring of blood glucose (SMBG) is also recommended to achieve greater time in range, with fewer extremes of hypo- or hyperglycemia. Unlike A1C, SMBG can distinguish among fasting, prandial, and postprandial hyperglycemia; uncover glycemic variability, including potentially dangerous hypoglycemia; and provide feedback to patients about the effects of behavior and medication on glycemic control...
September 25, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28932108/cognitive-and-behavioral-evaluation-of-nutritional-interventions-in-rodent-models-of-brain-aging-and-dementia
#7
REVIEW
Devin Wahl, Sean Cp Coogan, Samantha M Solon-Biet, Rafael de Cabo, James B Haran, David Raubenheimer, Victoria C Cogger, Mark P Mattson, Stephen J Simpson, David G Le Couteur
Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Although most interventional studies in rodent models of dementia have focused on pharmacological agents, there are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28926001/ketamine-differential-neurophysiological-dynamics-in-functional-networks-in-the-rat-brain
#8
A Ahnaou, H Huysmans, R Biermans, N V Manyakov, W H I M Drinkenburg
Recently, the N-methyl-d-aspartate-receptor (NMDAR) antagonist ketamine has emerged as a fast-onset mechanism to achieve antidepressant activity, whereas its psychomimetic, dissociative and amnestic effects have been well documented to pharmacologically model schizophrenia features in rodents. Sleep-wake architecture, neuronal oscillations and network connectivity are key mechanisms supporting brain plasticity and cognition, which are disrupted in mood disorders such as depression and schizophrenia. In rats, we investigated the dynamic effects of acute and chronic subcutaneous administration of ketamine (2...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28918936/intermittent-fasting-promotes-white-adipose-browning-and-decreases-obesity-by-shaping-the-gut%C3%A2-microbiota
#9
Guolin Li, Cen Xie, Siyu Lu, Robert G Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N Brocker, Tingting Yan, Kristopher W Krausz, Rong Xiang, Oksana Gavrilova, Andrew D Patterson, Frank J Gonzalez
While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its efficacy is poorly understood. Here, we show that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis...
October 3, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28895398/nearly-blinking-free-high-purity-single-photon-emission-by-colloidal-inp-znse-quantum-dots
#10
Vigneshwaran Chandrasekaran, Mickaël D Tessier, Dorian Dupont, Pieter Geiregat, Zeger Hens, Edouard Brainis
Colloidal core/shell InP/ZnSe quantum dots (QDs), recently produced using an improved synthesis method, have a great potential in life-science applications as well as in integrated quantum photonics and quantum information processing as single-photon emitters. Single-particle spectroscopy of 10 nm QDs with 3.2 nm cores reveals strong photon antibunching attributed to fast (70 ps) Auger recombination of multiple excitons. The QDs exhibit very good photostability under strong optical excitation. We demonstrate that the antibunching is preserved when the QDs are excited above the saturation intensity of the fundamental-exciton transition...
October 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28894645/re-examination-of-the-contribution-of-substrates-to-energy-expenditure-during-high-intensity-intermittent-exercise-in-endurance-athletes
#11
Zübeyde Aslankeser, Şükrü Serdar Balcı
BACKGROUND: It has been believed that the contribution of fat oxidation to total energy expenditure is becoming negligible at higher exercise intensities (about 85% VO2max). The aim of the present study was to examine the changes in substrate oxidation during high-intensity interval exercise in young adult men. METHODS: A total of 18 healthy well-trained (aged 19.60 ± 0.54 years, BMI = 22.19 ± 0.64 kg/m(2), n = 10) and untrained (aged 20.25 ± 0.41 years, BMI = 22...
2017: PeerJ
https://www.readbyqxmd.com/read/28853981/intermittent-fasting-preserves-beta-cell-mass-in-obesity-induced-diabetes-via-the-autophagy-lysosome-pathway
#12
Haiyan Liu, Ali Javaheri, Rebecca J Godar, John Murphy, Xiucui Ma, Nidhi Rohatgi, Jana Mahadevan, Krzysztof Hyrc, Paul Saftig, Connie Marshall, Michael L McDaniel, Maria S Remedi, Babak Razani, Fumihiko Urano, Abhinav Diwan
Obesity-induced diabetes is characterized by hyperglycemia, insulin resistance, and progressive beta cell failure. In islets of mice with obesity-induced diabetes, we observe increased beta cell death and impaired autophagic flux. We hypothesized that intermittent fasting, a clinically sustainable therapeutic strategy, stimulates autophagic flux to ameliorate obesity-induced diabetes. Our data show that despite continued high-fat intake, intermittent fasting restores autophagic flux in islets and improves glucose tolerance by enhancing glucose-stimulated insulin secretion, beta cell survival, and nuclear expression of NEUROG3, a marker of pancreatic regeneration...
August 30, 2017: Autophagy
https://www.readbyqxmd.com/read/28827428/from-slow-to-fast-faulting-recent-challenges-in-earthquake-fault-mechanics
#13
S Nielsen
Faults-thin zones of highly localized shear deformation in the Earth-accommodate strain on a momentous range of dimensions (millimetres to hundreds of kilometres for major plate boundaries) and of time intervals (from fractions of seconds during earthquake slip, to years of slow, aseismic slip and millions of years of intermittent activity). Traditionally, brittle faults have been distinguished from shear zones which deform by crystal plasticity (e.g. mylonites). However such brittle/plastic distinction becomes blurred when considering (i) deep earthquakes that happen under conditions of pressure and temperature where minerals are clearly in the plastic deformation regime (a clue for seismologists over several decades) and (ii) the extreme dynamic stress drop occurring during seismic slip acceleration on faults, requiring efficient weakening mechanisms...
September 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28825965/effects-of-intermitent-fasting-and-chronic-swimming-exercise-on-body-composition-and-lipid-metabolism
#14
Ruan Carlos Macêdo Moraes, Guilherme Vannucchi Portari, Alex Soares Marreiros Ferraz, Tiago Eugênio Oliveira Silva, Moacir Marocolo
Intermittent fasting protocol (IFP), has been suggested as a strategy to change body metabolism and improve health. The effects of IFP seem to be similar to aerobic exercise, having a hormetic adaptation according to intensity and frequency. However, the effects of combining both interventions are still unknown. Therefore, the aim of the present study was to evaluate the effects of IFP with and without endurance exercise training on body composition, food behavior, and lipid metabolism. Twenty weeks old Wistar rats were kept under an inverted circadian cycle of 12 hours with water ad libitum and assigned to four different groups: control group (CON; ad libitum feeding and sedentary); exercise group (EX; ad libitum feeding and endurance training); intermittent fasting group (IF; intermittent fasting and sedentary); intermittent fasting and exercise group (IFEX; intermittent fasting and endurance training)...
August 21, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28808490/the-influence-of-intermittent-fasting-on-the-circadian-pattern-of-melatonin-while-controlling-for-caloric-intake-energy-expenditure-light-exposure-and-sleep-schedules-a-preliminary-report
#15
Aljohara S Almeneessier, Ahmed S Bahammam, Munir M Sharif, Salman A Bahammam, Samar Z Nashwan, Seithikurippu R Pandi Perumal, Daniel P Cardinali, Mohammad Alzoghaibi
AIMS: We hypothesized that if we control for food composition, caloric intake, light exposure, sleep schedule, and exercise, intermittent fasting would not influence the circadian pattern of melatonin. Therefore, we designed this study to assess the effect of intermittent fasting on the circadian pattern of melatonin. METHODS: Eight healthy volunteers with a mean age of 26.6 ± 4.9 years and body mass index of 23.7 ± 3.5 kg/m(2) reported to the Sleep Disorders Center (the laboratory) on four occasions: (1) adaptation, (2) 4 weeks before Ramadan while performing Islamic intermittent fasting for 1 week (fasting outside Ramadan [FOR]), (3) 1 week before Ramadan (nonfasting baseline [BL]), and (4) during the 2(nd) week of Ramadan while fasting (Ramadan)...
July 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28797281/the-efficacy-of-transcutaneous-electrical-nerve-stimulation-on-the-improvement-of-walking-distance-in-patients-with-peripheral-arterial-disease-with-intermittent-claudication-study-protocol-for-a-randomised-controlled-trial-the-tens-pad-study
#16
Florent Besnier, Jean-Michel Sénard, Vincent Grémeaux, Mélanie Riédel, Damien Garrigues, Thibaut Guiraud, Marc Labrunée
BACKGROUND: In patients with peripheral arterial disease (PAD), walking improvements are often limited by early pain onset due to vascular claudication. It would thus appear interesting to develop noninvasive therapeutic strategies, such as transcutaneous electrical nerve stimulation (TENS), to improve the participation of PAD patients in rehabilitation programmes, and thus improve their quality of life. Our team recently tested the efficacy of a single 45-min session of 10-Hz TENS prior to walking...
August 10, 2017: Trials
https://www.readbyqxmd.com/read/28795793/an-unprecedented-case-a-low-specific-surface-area-anatase-n-doped-carbon-nanocomposite-derived-from-a-new-single-source-precursor-affords-fast-and-stable-lithium-storage
#17
Man Gao, Kaixiang Zou, Yuanfu Deng, Zhenxia Zhao, Yingwei Li, Guohua Chen
A nanocomposite of ultrafine anatase nanoparticles (<5 nm) embedded N-doped carbon (TiO2-NPs/NC) with a relatively low specific surface area was successfully synthesized by in situ pyrolysis of a new and cheap single source precursor of (H2en)3[Ti4(O2)4(Hcit)2(cit)2]·12H2O (en = ethylenediamine and H4cit = citric acid) under 550 °C and an inert atmosphere. The precursor in crystalline state was isolated from an aqueous solution containing of titanium butoxide, citric acid, hydrogen peroxide, and ethylenediamine and was characterized...
August 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28791787/is-two-days-of-intermittent-energy-restriction-per-week-a-feasible-weight-loss-approach-in-obese-males-a-randomised-pilot-study
#18
Marguerite Conley, Lauren Le Fevre, Cilla Haywood, Joseph Proietto
AIM: The 5:2 diet (two non-consecutive days of 2460 KJ (600 calories) and 5 days of ad libitum eating per week) is becoming increasingly popular. This pilot study aimed to determine whether the 5:2 diet can achieve ≥5% weight loss and greater improvements in weight and biochemical markers than a standard energy-restricted diet (SERD) in obese male war veterans. METHODS: A total of 24 participants were randomised to consume either the 5:2 diet or a SERD (2050 KJ (500 calorie) reduction per day) for 6 months...
August 9, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28770464/long-term-follow-up-in-a-girl-with-cystic-fibrosis-and-diabetes-since-the-first-year-of-life
#19
Valentina Fattorusso, Alida Casale, Valeria Raia, Enza Mozzillo, Adriana Franzese
Diabetes mellitus is the most common comorbidity in cystic fibrosis (CF). Recently, more attention has been paid to early glucose metabolism derangements (GMDs). The subject of this report is a female patient, affected by CF since 3 months of age. She presented with intermittent diabetes during early childhood. At the age of 10 years, oral glucose tolerance test (OGTT) was performed and showed glucose intolerance (IGT) status; glargine insulin therapy was started. At the age of 13 years, CF-related diabetes with fasting hyperglycemia occurred, so rapid insulin at meals was added...
August 2, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28761067/every-other-day-feeding-extends-lifespan-but-fails-to-delay-many-symptoms-of-aging-in-mice
#20
Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S Henzel, Sabine M Hölter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L Pearson, Ildiko Racz, Birgit Rathkolb, Devon P Ryan, Susanne Schröder, Irina Treise, Raffi Bekeredjian, Dirk H Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Dan Ehninger
Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls...
July 24, 2017: Nature Communications
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