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Cardiac emergency medicine

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https://www.readbyqxmd.com/read/29884521/nonaneurysmal-pseudo-subarachnoid-hemorrhage-computed-tomography-patterns-challenges-in-an-acute-decision-making-heuristics
#1
Tasneem F Hasan, Walter Duarte, Oluwaseun O Akinduro, Eric D Goldstein, Rebecca Hurst, Neil Haranhalli, David A Miller, Robert E Wharen, Rabih G Tawk, William D Freeman
BACKGROUND: Acute aneurysmal subarachnoid hemorrhage (SAH) is a medical and neurosurgical emergency from ruptured brain aneurysm. Aneurysmal SAH is identified on brain computed tomography (CT) as increased density of basal cisterns and subarachnoid spaces from acute blood products. Aneurysmal SAH-like pattern on CT appears as an optical illusion effect of hypodense brain parenchyma and/or hyperdense surrounding cerebral cisterns and blood vessels termed as "pseudo-subarachnoid hemorrhage" (pseudo-SAH)...
June 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29882416/role-of-insulin-like-growth-factor-1-receptor-signaling-in-stem-cell-stemness-and-therapeutic-efficacy
#2
Chiao-Fang Teng, Long-Bin Jeng, Woei-Cherng Shyu
Evidence has emerged that stem cells represent a promising therapeutic tool for tissue engineering and regenerative medicine. Thus, identifying functional markers for selecting stem cells capable of superior self-renewal and pluripotency (or multipotency) and maintaining stem cell identity under appropriate culture conditions are critical for guiding the use of stem cells toward clinical applications. Many investigations have implicated the insulin-like growth factor 1 receptor (IGF1R) signaling in maintenance of stem cell characteristics and enhancement of stem cell therapy efficacy...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29876869/the-great-harmony-in-translational-medicine-biomaterials-and-stem-cells
#3
Evren Erten, Yavuz Emre Arslan
Thanks to novel approaches and emerging technologies, tissue engineering and regenerative medicine have made a great effort to regenerate damaged tissue or organ with no donor needed. The approaches involve two fundamental components: bioengineered scaffolds and stem cells. Bioengineered scaffolds which can also be enriched with bioactive molecules such as cytokines, growth factors, and so on have been fabricated using a wide range of synthetically or naturally derived biodegradable and biocompatible polymers...
June 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29801958/hospital-referral-of-detainees-during-police-custody-in-amsterdam-the-netherlands
#4
T Dorn, A Janssen, J C de Keijzer, G L van Rijk-Zwikker, U J L Reijnders, J S K Luitse, E Vandewalle, M P Gorzeman, R C van Nieuwenhuizen, M Ceelen, C Das
This study describes how many detainees have been referred to emergency departments for further evaluation or emergency care while in police custody in Amsterdam (years 2012/2013). It provides insights into the diagnoses assigned by forensic doctors and hospital specialists and the appropriateness of the referrals. We made use of the electronic registration system of the Forensic Medicine Department of the Public Health Service Amsterdam. This department is in charge of the medical care for detainees in the Amsterdam region...
July 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29800914/carbon-nanotube-scaffolds-as-emerging-nanoplatform-for-myocardial-tissue-regeneration-a-review-of-recent-developments-and-therapeutic-implications
#5
REVIEW
Bapi Gorain, Hira Choudhury, Manisha Pandey, Prashant Kesharwani, Muhammad Mustafa Abeer, Rakesh Kumar Tekade, Zahid Hussain
Myocardial infarction (cardiac tissue death) is among the most prevalent causes of death among the cardiac patients due to the inability of self-repair in cardiac tissues. Myocardial tissue engineering is regarded as one of the most realistic strategies for repairing damaged cardiac tissue. However, hindrance in transduction of electric signals across the cardiomyocytes due to insulating properties of polymeric materials worsens the clinical viability of myocardial tissue engineering. Aligned and conductive scaffolds based on Carbon nanotubes (CNT) have gained remarkable recognition due to their exceptional attributes which provide synthetic but viable microenvironment for regeneration of engineered cardiomyocytes...
May 22, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793987/advocating-for-life-support-training-of-children-parents-caregivers-school-personnel-and-the-public
#6
James M Callahan, Susan M Fuchs
Out-of-hospital cardiac arrest occurs frequently among people of all ages, including more than 6000 children annually. Pediatric cardiac arrest in the out-of-hospital setting is a stressful event for family, friends, caregivers, classmates, school personnel, and witnesses. Immediate bystander cardiopulmonary resuscitation and the use of automated external defibrillators are associated with improved survival in adults. There is some evidence in which improved survival in children who receive immediate bystander cardiopulmonary resuscitation is shown...
May 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/29793985/advocating-for-life-support-training-of-children-parents-caregivers-school-personnel-and-the-public
#7
Susan M Fuchs
Pediatric cardiac arrest in the out-of-hospital setting is a traumatic event for family, friends, caregivers, classmates, and school personnel. Immediate bystander cardiopulmonary resuscitation and the use of automatic external defibrillators have been shown to improve survival in adults. There is some evidence to show improved survival in children who receive immediate bystander cardiopulmonary resuscitation. Pediatricians, in their role as advocates to improve the health of all children, are uniquely positioned to strongly encourage the training of children, parents, caregivers, school personnel, and the lay public in the provision of basic life support, including pediatric basic life support, as well as the appropriate use of automated external defibrillators...
May 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/29772252/sulfiredoxin-1-enhances-cardiac-progenitor-cell-survival-against-oxidative-stress-via-the-upregulation-of-the-erk-nrf2-signal-pathway
#8
Xiuchun Li, Pan He, Xiaoliang Wang, Shuning Zhang, Neil Devejian, Edward Bennett, Chuanxi Cai
Cardiac stem/progenitor cells (CPCs) have recently emerged as a potentially transformative regenerative medicine to repair the infarcted heart. However, the limited survival of donor cells is one of the major challenges for CPC therapy. Our recent research effort on preconditioning human CPCs (hCPCs) with cobalt protoporphyrin (CoPP) indicated that sulfiredoxin-1 (SRXN1) is upregulated upon preconditioning aldehyde dehydrogenase bright hCPCs (ALDHbr -hCPCs) with CoPP. Further studies demonstrated that overexpressing SRXN1 enhanced the survival capacity for ALDHbr -hCPCs...
May 14, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29754417/teaching-paediatric-basic-life-support-in-medical-schools-using-peer-teaching-or-video-demonstration-a-prospective-randomised-trial
#9
Frederik Stephan, Hanjo Groetschel, Anja K Büscher, Deniz Serdar, Kjell A Groes, Rainer Büscher
AIM: The outcome of children with an out-of-hospital cardiac arrest is still poor, but bystander cardiopulmonary resuscitation can increase survival and minimise severe neurological sequelae. While teaching basic life support is standardised in emergency medicine classes, paediatric basic life support (PBLS) in neonates and toddlers is under-represented in paediatric curricula during university education. The appropriate mixture of E-learning and peer teaching lessons remains controversial in teaching paediatric basic skills...
May 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29746359/evaluation-of-a-focused-cardiac-ultrasound-protocol-in-a-pediatric-emergency-department
#10
Antonio Riera, Bevin Weeks, Beth L Emerson, Lei Chen
OBJECTIVES: The objective of this study was to evaluate the implementation of a focused cardiac ultrasound (FoCUS) protocol in a pediatric emergency department (PED). METHODS: We conducted a cross-sectional, observational, quality improvement project in a PED of an urban tertiary care children's hospital. A FoCUS protocol was collaboratively developed by pediatric cardiology and pediatric emergency medicine. This included a reference document with definitions, indications, image acquisition guidelines, and interpretation expectations...
May 9, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29740831/do-emergency-physicians-rely-on-point-of-care-ultrasound-for-clinical-decision-making-without-additional-confirmatory-testing
#11
Mohamad Moussa, Julie M Stausmire
PURPOSE: It is unknown if Emergency Physicians (EPs) rely solely on Emergency Medicine performed Point-Of-Care Ultrasound (EM-POCUS) for clinical decision making or if they proceed to subsequent "gold standard" studies for confirmatory diagnosis. METHODS: After Institutional Review Board approval, an online survey was distributed by the Ohio Chapter of the American College of Emergency Physicians to its members. RESULTS: The most common EM-POCUS procedures used without confirmatory testing were: determination of cardiac activity during cardiac arrest (81...
May 8, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29730774/in-flight-cardiac-arrest-and-in-flight-cardiopulmonary-resuscitation-during-commercial-air-travel-consensus-statement-and-supplementary-treatment-guideline-from-the-german-society-of-aerospace-medicine-dglrm
#12
Jochen Hinkelbein, Lennert Böhm, Stefan Braunecker, Harald V Genzwürker, Steffen Kalina, Fabrizio Cirillo, Matthieu Komorowski, Andreas Hohn, Jörg Siedenburg, Michael Bernhard, Ilse Janicke, Christoph Adler, Stefanie Jansen, Eckard Glaser, Pawel Krawczyk, Mirko Miesen, Janusz Andres, Edoardo De Robertis, Christopher Neuhaus
By the end of the year 2016, approximately 3 billion people worldwide travelled by commercial air transport. Between 1 out of 14,000 and 1 out of 50,000 passengers will experience acute medical problems/emergencies during a flight (i.e., in-flight medical emergency). Cardiac arrest accounts for 0.3% of all in-flight medical emergencies. So far, no specific guideline exists for the management and treatment of in-flight cardiac arrest (IFCA). A task force with clinical and investigational expertise in aviation, aviation medicine, and emergency medicine was created to develop a consensus based on scientific evidence and compiled a guideline for the management and treatment of in-flight cardiac arrests...
May 5, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29714134/medicinal-chemistry-of-potassium-channel-modulators-an-update-of-recent-progress-2011-2017
#13
Vivek K Vyas, Palak Parikh, Jonali Ramani, Manjunath Ghate
BACKGROUND: Potassium (K+) channels participate in many physiological processes, cardiac function, cell proliferation, neuronal signaling, muscle contractility, immune function, hormone secretion, osmotic pressure, changes in gene expression, and are involved in critical biological functions, and in a variety of diseases. Potassium channels represent a large family of tetrameric membrane proteins. Potassium channels activation reduces excitability, whereas channel inhibition increases excitability...
April 30, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29705730/paediatric-traumatic-cardiac-arrest-a-delphi-study-to-establish-consensus-on-definition-and-management
#14
Annette C Rickard, James Vassallo, Tim Nutbeam, Mark D Lyttle, Ian K Maconochie, Doyo G Enki, Jason E Smith
AIMS: Paediatric traumatic cardiac arrest (TCA) is associated with low survival and poor outcomes. The mechanisms that underlie TCA are different from medical cardiac arrest; the approach to treatment of TCA may therefore also need to differ to optimise outcomes. The aim of this study was to explore the opinion of subject matter experts regarding the diagnosis and treatment of paediatric TCA, and to reach consensus on how best to manage this group of patients. METHODS: An online Delphi study was conducted over three rounds, with the aim of achieving consensus (defined as 70% agreement) on statements related to the diagnosis and management of paediatric TCA...
April 28, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29702382/flexible-multichannel-vagus-nerve-electrode-for-stimulation-and-recording-for-heart-failure-treatment
#15
Ning Xue, Ignacio Delgado Martinez, Jianhai Sun, Yuhua Cheng, Chunxiu Liu
Vagus nerve stimulation is an emerging bioelectronic medicine to modulate cardiac function, as the nerve provides parasympathetic innervation to the heart. In this study, we developed a polyimide based 2D cuff electrode to wrap around on the vagus nerve. Thanks to the tiny size and bendable protruding structure of the contact tips of the device, the electrode sites are able to flexibly bend to touch the nerve, selectively record and stimulate the vagus nerve. Gold, platinum and platinum black materials were chosen to compose the electrodes for nerve stimulation and recording, respectively...
April 20, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29688817/current-status-of-messenger-rna-delivery-systems
#16
Matthew G Stanton
Messenger RNA is emerging as a highly versatile biological construct for creation of impactful medicines. mRNA vaccines directed toward infectious disease and cancer are in clinical development with encouraging early reads on tolerability and efficacy. The use of mRNA to direct intense but transient expression of paracrine factors is finding utility in reprogramming progenitor cells for wound healing and cardiac regeneration and for stimulation of antitumor immune responses, at least preclinically as we await clinical results...
June 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29688110/a-mixed-methods-evaluation-of-a-multidisciplinary-point-of-care-ultrasound-program
#17
Andrew Smith, Michael Parsons, Tia Renouf, Sarah Boyd, Peter Rogers
BACKGROUND: Point of Care Ultrasound (PoCUS) is well established within emergency medicine, however, the availability of formal training for other clinical disciplines is limited. Memorial University has established a cost-efficient, multidisciplinary PoCUS training program focusing on training residents' discipline-specific ultrasound skills. This study evaluates the skills, knowledge, and attitudes of residents who participated in the program. METHODS: Analysis was conducted using a mixed-methods, sequential exploratory approach...
April 24, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29685008/medicamentous-thrombolysis-disguises-pulmonary-thromboembolism-as-a-cause-of-death
#18
I Šoša, A Ferencic, V Stemberga, G Zamolo, S Arbanas, I Dasek, M Perkovic, D Cuculic
We report the case of a 31-year-old female who was admitted to the emergency department with symptoms of cardiac arrest and ultimately died in spite of enormous resuscitation efforts. During resuscitation, pulmonary embolism was considered as a possible non-cardiac cause of cardiac arrest, and following its extremely unfavorable prognosis, the fatal outcome was not so surprising. However, since acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments was suspected, alteplase was indicated and administered...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29669228/case-12-2018-a-30-year-old-woman-with-cardiac-arrest
#19
Joshua N Goldstein, David M Dudzinski, Timothy B Erickson, Grace Linder
Presentation of Case. Dr. Emily C. Cleveland (Emergency Medicine): A 30-year-old woman was brought to the emergency department of this hospital because of cardiac arrest. On the morning of this presentation, the patient was found unresponsive in her bedroom. Her mother called emergency medical..
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29665190/comparison-of-emergency-medicine-malpractice-cases-involving-residents-to-non-resident-cases
#20
Kiersten L Gurley, Shamai A Grossman, Margaret Janes, C Winnie Yu-Moe, Ellen Song, Carrie D Tibbles, Nathan I Shapiro, Carlo L Rosen
BACKGROUND: Data are lacking on how emergency medicine (EM) malpractice cases with resident involvement differs from cases that do not name a resident. OBJECTIVES: To compare malpractice case characteristics in cases where a resident is involved (resident case) to cases that do not involve a resident (non-resident case) and to determine factors that contribute to malpractice cases utilizing EM as a model for malpractice claims across other medical specialties. METHODS: We used data from the Controlled Risk Insurance Company (CRICO) Strategies' division Comparative Benchmarking System (CBS) to analyze open and closed EM cases asserted from 2009-2013...
April 17, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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