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https://www.readbyqxmd.com/read/27904709/braf-and-epithelial-mesenchymal-transition-in-papillary-thyroid-carcinoma-challenging-the-roles-of-snail-and-e-cadherin
#1
Brendon Mitchell, Dominick Leone, Shi Yang, Ashraf Khan, Meera Mahalingam, Jagdish Dhingra
OBJECTIVE: In papillary thyroid carcinoma (PTC), while the role of BRAF is well established, the contribution of BRAF to epithelial-mesenchymal transition is not. STUDY DESIGN/SETTING: To elucidate the relationship between BRAF, surrogates of epithelial-mesenchymal transition (Snail, E-cadherin) and established histopathologic prognosticators in papillary thyroid carcinoma. SUBJECTS/METHODS: In this IRB approved cross-sectional study, 50 cases of archived annotated PTC samples were retrieved and immunohistochemically stained for Snail and E-cadherin protein...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27896649/the-micropapillary-hobnail-variant-of-papillary-thyroid-carcinoma-a-review-of-series-described-in-the-literature-compared-to-a-series-from-one-southern-italy-pathology-institution
#2
REVIEW
Antonio Ieni, Valeria Barresi, Roberta Cardia, Luana Licata, Flavia Di Bari, Salvatore Benvenga, Giovanni Tuccari
Papillary thyroid carcinoma (PTC) has a good prognosis with a 10-yr survival greater than 90%. Recently, a micro-papillary pattern with hobnail appearance (MPHC) in PTC has been indicated as associated with poor prognosis, but this suggestion is based only on a few cases from geographical areas different from ours. Two-hundred ninety-nine consecutive PTC cases were collected between the years of 1992 and 2014 at our institution. The corresponding histologic sections (at least 6 for each case) were stained with hematoxylin and eosin and reviewed independently by two pathologists to reach a consensus on the identification and quantification of the MPHC...
November 28, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27886677/differences-in-global-dna-methylation-of-testicular-seminoma-are-not-associated-with-changes-in-histone-modifications-clinical-prognosis-braf-mutations-or-gene-expression
#3
Louise Holm Pedersen, John E Nielsen, Gedske Daugaard, Thomas V O Hansen, Ewa Rajpert-De Meyts, Kristian Almstrup
Testicular germ cell tumours of young adults are comprised of a heterogeneous group of non-seminomas and a homogeneous group of seminomas. While the majority of seminomas retain a hypo-methylated genome, a small fraction displays a highly methylated genome, resembling hyper-methylated non-seminomas. It is well established from e.g. melanoma, colorectal and thyroid cancer that a methylated phenotype can be correlated to prognosis and can be related to BRAF mutations. In the present study we investigated the global methylation level in 67 seminomas and classified them as hypo-methylated, intermediate, patchy and hyper-methylated, respectively...
November 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27880942/acquired-resistance-to-braf-inhibition-induces-epithelial-to-mesenchymal-transition-in-braf-v600e-mutant-thyroid-cancer-by-c-met-mediated-akt-activation
#4
Hyung Kwon Byeon, Hwi Jung Na, Yeon Ju Yang, Sooah Ko, Sun Och Yoon, Minhee Ku, Jaemoon Yang, Jae Wook Kim, Myung Jin Ban, Ji-Hoon Kim, Da Hee Kim, Jung Min Kim, Eun Chang Choi, Chang-Hoon Kim, Joo-Heon Yoon, Yoon Woo Koh
Previously, the authors have identified that c-Met mediates reactivation of the PI3K/AKT pathway following BRAF inhibitor treatment in BRAF (V600E) mutant anaplastic thyroid cancer, thereby contributing to the acquired drug resistance. Therefore dual inhibition of BRAF and c-Met led to sustained treatment response, thereby maximizing the specific anti-tumor effect of targeted therapy. The present study goes one step further and aims to investigate the effect of acquired resistance of BRAF inhibitor on epithelial-to-mesenchymal transition (EMT) in BRAF mutant thyroid cancer cells and the effect of dual inhibition from combinatorial therapy...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27875244/a-six-genotype-genetic-prognostic-model-for-papillary-thyroid-cancer
#5
Xiaopei Shen, Rengyun Liu, Mingzhao Xing
A unique prognostic role of the genetic duet of BRAF V600E and TERT promoter mutation in papillary thyroid cancer (PTC) has been recently established, but the role of RAS mutation in this genetic interplay remains to be established. Using The Cancer Genome Atlas (TCGA) data of patients with PTC from 19 medical centers, we investigated interactions among the three mutations in clinical outcomes of PTC. We found that BRAF and RAS mutations were mutually exclusive but both were associated with TERT promoter mutations, with the genetic duet of BRAF/RAS and TERT mutations occurring in 34/388 (8...
November 14, 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27873522/extremely-well-differentiated-papillary-thyroid-carcinoma-resembling-adenomatous-hyperplasia-can-metastasize-to-the-skull-a-case-report
#6
Ju Yeon Pyo, Jisup Kim, Sung Eun Choi, Eunah Shin, Seok Woo Yang, Cheong Soo Park, Seok Mo Kim, Soonwon Hong
We describe herein histologic, immunohistochemical, and molecular findings and clinical manifestations of a rare case of an extremely well differentiated papillary thyroid carcinoma (EWD-PTC). Similarly, it is also difficult to diagnose follicular variant papillary thyroid carcinoma (FVPTC), whose diagnosis is still met with controversy. A recently reported entity of well-differentiated tumor of uncertain malignant potential (WDT-UMP) is added to the diagnostic spectrum harboring EWD-PTC and FVPTC. We report this case, because EWD-PTC is different from FVPTC in its papillary architecture, and also from WDT-UMP in its recurrence and metastatic pattern...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27867864/braf-v600e-mutation-in-prognostication-of-papillary-thyroid-cancer-ptc-recurrence
#7
REVIEW
Agnieszka Czarniecka, Małgorzata Oczko-Wojciechowska, Marcin Barczyński
Papillary thyroid cancer (PTC) offers excellent prognosis, however relapse risk or persistent disease is related to ~30%. Currently, attention is paid to the possibility of patient group selection of different risk of unfavorable outcome to match a particular therapeutic approach. Therefore, interest in new prognostic and predictive markers known preoperatively is observed. BRAF V600E mutation is such a marker. Many studies analyzing the prevalence of the mutation and its relationship with other clinico-pathological risk factors were reported but with controversial conclusions...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27866718/mutational-analysis-of-metastatic-lymph-nodes-from-papillary-thyroid-carcinoma-in-adult-and-pediatric-patients
#8
Alexander L Shifrin, Michele Fischer, Trevor Paul, Brian Erler, Katherine Gheysens, Prachi Baodhankar, Joanna W Song-Yang, Samantha Taylor, Venkata Arun Timmaraju, Arthur Topilow, Alidad Mireskandari, Gyanendra Kumar
BACKGROUND: Limited data are available on the analysis of somatic mutations in metastatic lymph nodes in adult and pediatric patients with papillary thyroid carcinomas. METHODS: A total of 92, microdissected, formalin-fixed, paraffin-embedded tissue specimens from 39 patients were analyzed for the presence of somatic mutations utilizing the ThyGenX next-generation sequencing test. RESULTS: Somatic mutations were detected in 67% of papillary thyroid carcinoma specimens...
November 17, 2016: Surgery
https://www.readbyqxmd.com/read/27865374/clinical-implications-of-the-extent-of-braf-v600e-alleles-in-patients-with-papillary-thyroid-carcinoma
#9
Lihua Liu, Jae Won Chang, Seung-Nam Jung, Hee Sung Park, Taejeong Oh, Young Chang Lim, Bon Seok Koo
OBJECTIVE: There are many conflicting reports about the clinical implications of BRAF(V600E) in papillary thyroid cancer (PTC). We investigated the associations between the extent of BRAF(V600E) alleles and both clinico-pathological features and recurrence of PTC. MATERIALS AND METHODS: Carcinoma tissues from 60 patients with PTC were genotyped for BRAF(V600E) using pyrosequencing, and the clinico-pathological factors and disease outcomes of the patients were examined...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27863429/epigenetically-upregulated-wipf1-plays-a-major-role-in-braf-v600e-promoted-papillary-thyroid-cancer-aggressiveness
#10
Tao Zhang, Xiaopei Shen, Rengyun Liu, Guangwu Zhu, Justin Bishop, Mingzhao Xing
How the BRAF V600E mutation promotes the pathogenesis and aggressiveness of papillary thyroid cancer (PTC) is not completely understood. Here we explored a novel mechanism involving WASP interacting protein family member 1 (WIPF1). In PTC tumors, compared with the wild-type BRAF, BRAF V600E was associated with over-expression and hypomethylation of the WIPF1 gene. In thyroid cancer cell lines with wild-type BRAF, WIPF1 expression was robustly upregulated upon introduced expression of BRAF V600E (P=0.03) whereas the opposite was seen upon BRAF knockdown or treatment with BRAF V600E or MEK inhibitors in cells harboring BRAF V600E...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27849443/fusion-oncogenes-are-the-main-genetic-events-found-in-sporadic-papillary-thyroid-carcinomas-from-children
#11
Maria Isabel Cunha Vieira Cordioli, Lais Moraes, André Uchimura Bastos, Paloma Besson, Maria Teresa de Seixas Alves, Rosana Delcelo, Osmar Monte, Carlos A Longui, Adriano Namo Cury, Janete Cerutti
BACKGROUND: Previous studies reported significant differences in the clinical presentation and outcomes of papillary thyroid carcinoma (PTC) in pediatric patients compared to adults. Previous studies have suggested that the clinicopathological differences observed between pediatric and adult PTC may be due the existence of distinct genetic alterations. However, the knowledge of genetic events in pediatric PTC is based primarily on studies in radiation-exposed PTC or in few studies that enrolled predominantly adolescent patients...
November 16, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27843810/braf-v600e-mutation-has-it-a-role-in-cervical-lymph-node-metastasis-of-papillary-thyroid-cancer
#12
Neslihan Kurtulmus, Burak Ertas, Yesim Saglican, Hakan Kaya, Umit Ince, Mete Duren
BACKGROUND: The BRAF(V600E) mutation is common in papillary thyroid cancer (PTC). Lymph node metastasis (LNM) may be associated with poor prognosis. However, the LNM mechanism remains unclear. OBJECTIVES: Our aim was to evaluate the prevalence of the BRAF(V600E) mutation in primary tumors and accompanying LNM at the time of diagnosis. METHODS: This retrospective study included 51 PTC patients (40 women, 11 men; mean age 40.0 ± 16.5 years; range 6-81) who underwent total thyroidectomy accompanied by a lateral neck dissection due to preoperatively detected LNM...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27834723/classical-papillary-thyroid-carcinoma-with-multiple-recurrences-gradually-evolving-into-tall-cell-variant-and-tenis-histopathology-imaging-characteristics-and-documentation-of-braf-v600e-along-with-a-rare-braf-i582m-mutation
#13
Avik Chakraborty, Subhada Kane, Yogita Pawar, Sandip Basu
: We herein report an unusual case of 55 year old female with papillary carcinoma of thyroid, who presented with multiple recurrences, with its subsequent evolution to tall cell variant (TCV) and thyroglobulin-elevated negative iodine scintigraphy (TENIS). METHODOLOGY: During the course of the disease the lesions became noniodine concentrating with increased proportion of tall cells and evidence of local and distant metastasis. Molecular analysis of the tissue specimen demonstrated BRAF V600E and I582M mutations along with upregulation of tumor markers in metastatic tissue...
November 10, 2016: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27834083/molecular-diagnosis-using-residual-liquid-based-cytology-materials-for-patients-with-nondiagnostic-or-indeterminate-thyroid-nodules
#14
Hyemi Kwon, Won Gu Kim, Markus Eszlinger, Ralf Paschke, Dong Eun Song, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim
BACKGROUND: Molecular analysis for common somatic mutations in thyroid cancer can improve diagnostic accuracy of fine-needle aspiration cytology (FNAC) in the nondiagnostic or indeterminate category of thyroid nodules. In this study, we evaluated the feasibility of molecular diagnosis from residual liquid-based cytology (LBC) material after cytological diagnosis. METHODS: This prospective study enrolled 53 patients with thyroid nodules diagnosed as nondiagnostic, atypia of undetermined significance (AUS), or follicular lesion of undetermined significance (FLUS) after FNAC...
November 4, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27833153/tert-promoter-mutation-and-its-association-with-clinicopathological-features-and-prognosis-of-papillary-thyroid-cancer-a-meta-analysis
#15
Chunping Liu, Zeming Liu, Tianwen Chen, Wen Zeng, Yawen Guo, Tao Huang
We performed a meta-analysis to elucidate the associations of the clinicopathological characteristics and prognostic factors of papillary thyroid cancer (PTC) with TERT promoter mutations. A literature search was performed of the PubMed and EMBASE databases using Medical Subject Headings and keywords. Individual study-specific odds ratios (ORs) and confidence intervals (CIs) were calculated. The average prevalence rate of TERT promoter mutations was 10.1%. TERT promoter mutations occurred more frequently in patients with larger tumors (p = 0...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27833134/long-intergenic-non-coding-rna-271-is-predictive-of-a-poorer-prognosis-of-papillary-thyroid-cancer
#16
Ben Ma, Tian Liao, Duo Wen, Chuanpeng Dong, Li Zhou, Shuwen Yang, Yu Wang, Qinghai Ji
A number of long non-coding RNAs (lncRNAs) have been found to play critical roles in oncogenesis and tumor progression. We aimed to investigate whether lncRNAs could act as prognostic biomarkers for papillary thyroid cancer (PTC) that may assist us in evaluating disease status and prognosis for patients. We found 220 lncRNAs with expression alteration from the annotated 2773 lncRNAs approved by the HUGO gene nomenclature committee in The Cancer Genome Atlas (TCGA) dataset, of which FAM41C, CTBP1-AS2, LINC00271, HAR1A, LINC00310 and HAS2-AS1 were associated with recurrence...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27829211/metastatic-papillary-thyroid-carcinoma-with-adjacent-braf-v600e-mutated-squamous-cell-carcinoma
#17
Asha Rupani, Owain R Hughes, John Watkinson, Christopher M Nutting, Khin Thway
No abstract text is available yet for this article.
October 21, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27824297/single-point-mutations-in-pediatric-differentiated-thyroid-cancer
#18
Ali S Alzahrani, Avaniyapuram Kannan Murugan, Ebtesam Qasem, Meshael Alswailem, Hindi Nassir Al-Hindi, Yufei Shi
PURPOSE: Differentiated Thyroid Cancer (DTC) is rare in children. Previous studies suggested that it has different clinicopathological features and mutation profiles compared with adult DTC. However, those studies focused on single or a limited number of gene mutations. We comprehensively studied a large series of pediatric DTC for single point mutations in BRAF, HRAS, KRAS, NRAS, PIK3CA, PTEN and TERT. We also analyzed associations between clinicopathological features and the BRAFV600Emutation...
November 8, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27822408/microarray-expression-profiling-identifies-genes-including-cytokines-and-biofunctions-as-diapedesis-associated-with-a-brain-metastasis-from-a-papillary-thyroid-carcinoma
#19
Hans-Juergen Schulten, Deema Hussein, Fatima Al-Adwani, Sajjad Karim, Jaudah Al-Maghrabi, Mona Al-Sharif, Awatif Jamal, Sherin Bakhashab, Jolanta Weaver, Fahad Al-Ghamdi, Saleh S Baeesa, Mohammed Bangash, Adeel Chaudhary, Mohammed Al-Qahtani
Brain metastatic papillary thyroid carcinomas (PTCs) are afflicted with unfavorable prognosis; however, the underlying molecular genetics of these rare metastases are virtually unknown. In this study, we compared whole transcript microarray expression profiles of a BRAF mutant, brain metastasis from a PTC, including its technical replicate (TR), with eight non-brain metastatic PTCs and eight primary brain tumors. The top 95 probe sets (false discovery rate (FDR) p-value < 0.05 and fold change (FC) > 2) that were differentially expressed between the brain metastatic PTC, including the TR, and both, non-brain metastatic PTCs and primary brain tumors were in the vast majority upregulated and comprise, e...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27818286/inverse-expression-of-caveolin-1-and-egfr-in-thyroid-cancer-patients
#20
Jelena Janković, Svetislav Tatić, Vesna Božić, Vladan Živaljević, Dubravka Cvejić, Svetlana Paskaš
Cytological analysis of fine-needle aspiration (FNA) is the first step in evaluation of patients with nodular thyroid disease with the primary goal to exclude thyroid malignancy. Its improvement by combining cytology with molecular markers is still a matter of investigation. In this study two molecular markers were used: caveolin-1 and EGFR, along with the well-established genetic marker - BRAF V600E mutation. We set out to determine the expression signatures of EGFR and caveolin-1, in patients with thyroid malignancy, as well as to determine their possible association with disease severity...
November 3, 2016: Human Pathology
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