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https://www.readbyqxmd.com/read/29351623/development-of-sugar-chain-binding-single-chain-variable-fragment-antibody-to-adult-t-cell-leukemia-cells-using-glyco-nanotechnology-and-phage-display-method
#1
Kaname Muchima, Taro Todaka, Hiroyuki Shinchi, Ayaka Sato, Arisa Tazoe, Rikiya Aramaki, Yuhei Kakitsubata, Risa Yokoyama, Naomichi Arima, Masanori Baba, Masahiro Wakao, Yuji Ito, Yasuo Suda
Adult T-cell leukemia (ATL) is an intractable blood cancer caused by the infection of human T-cell leukemia virus type-1, and effective medical treatment is required. It is known that the structure and expression levels of cell surface sugar chains vary depending on cell states such as inflammation and cancer. Thus, it is expected that the antibody specific for ATL cell surface sugar chain would be an effective diagnostic tool and a strong candidate for the development of an anti-ATL drug. Here, we developed a stable sugar chain binding single chain variable fragment antibody (scFv) that can bind to ATL cells using a fiber type Sugar Chip and phage display method...
January 17, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29349891/research-on-the-preparation-uniformity-and-stability-of-mixed-standard-substance-for-rapid-detection-of-goat-milk-composition
#2
Yuying Zhu, Jianmin Wang, Cunfang Wang
Taking fresh goat milk as raw material after filtering, centrifuging, hollow fiber ultrafiltration, allocating formula, value detection and preparation processing, a set of 10 goat milk mixed standard substances was prepared on the basis of one-factor-at-a-time using a uniform design method, and its accuracy, uniformity and stability were evaluated by paired t-test and F-test of one-way analysis of variance. The results showed that three milk composition contents of these standard products were independent of each other, and the preparation using the quasi-level design method, and without emulsifier was the best program...
January 19, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29349656/correlations-among-multifocal-electroretinography-and-optical-coherence-tomography-findings-in-patients-with-parkinson-s-disease
#3
Metin Unlu, Duygu Gulmez Sevim, Murat Gultekin, Cagatay Karaca
To assess the correlation between functional and anatomical evaluations with multifocal electroretinography (mfERG) and spectral-domain optical coherence tomography (SD-OCT) in patients with Parkinson's disease (PD). This cross-sectional study involved 116 eyes of 58 patients with PD and 30 age- and sex-matched control subjects. All study participants underwent a comprehensive neuro-ophthalmic examination, retinal single-layer thicknesses and volumes, and peripapillary retinal nerve fiber layer (pRNFL) measurements with SD-OCT, and the patients' mfERG recordings were evaluated...
January 18, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29346962/osmotic-mechanism-of-the-loop-extrusion-process
#4
Tetsuya Yamamoto, Helmut Schiessel
The loop extrusion theory assumes that protein factors, such as cohesin rings, act as molecular motors that extrude chromatin loops. However, recent single molecule experiments have shown that cohesin does not show motor activity. To predict the physical mechanism involved in loop extrusion, we here theoretically analyze the dynamics of cohesin rings on a loop, where a cohesin loader is in the middle and unloaders at the ends. Cohesin monomers bind to the loader rather frequently and cohesin dimers bind to this site only occasionally...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346894/size-scaling-of-failure-strength-with-fat-tailed-disorder-in-a-fiber-bundle-model
#5
Viktória Kádár, Zsuzsa Danku, Ferenc Kun
We investigate the size scaling of the macroscopic fracture strength of heterogeneous materials when microscopic disorder is controlled by fat-tailed distributions. We consider a fiber bundle model where the strength of single fibers is described by a power law distribution over a finite range. Tuning the amount of disorder by varying the power law exponent and the upper cutoff of fibers' strength, in the limit of equal load sharing an astonishing size effect is revealed: For small system sizes the bundle strength increases with the number of fibers, and the usual decreasing size effect of heterogeneous materials is restored only beyond a characteristic size...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346296/highly-sensitive-strain-sensor-based-on-a-novel-mach-zehnder-interferometer-with-tcf-pcf-structure
#6
Xinran Dong, Haifeng Du, Zhi Luo, Ji'an Duan
A highly sensitive strain sensor based on a novel fiber in line Mach-Zehnder interferometer (MZI) was demonstrated experimentally. The MZI was realized by splicing a section of photonic crystal fiber (PCF) with the same length of thin core fiber (TCF) between two single mode fibers (SMFs). The fringe visibility of MZI can reach as high as 20 dB in air. In particular, the strain sensitivity of -1.95 pm/με was achieved within a range from 0 to 4000 με. Furthermore, the strain properties of different length of MZI was investigated...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29346293/fabry-perot-interferometric-high-temperature-sensing-up-to-1200-%C3%A2-c-based-on-a-silica-glass-photonic-crystal-fiber
#7
Haihu Yu, Ying Wang, Jian Ma, Zhou Zheng, Zhuozhao Luo, Yu Zheng
A Fabry-Perot interferometric sensor for temperature measurement was fabricated based on a silica glass solid-core photonic crystal fiber with a central air-bore. By splicing a stub of photonic crystal fiber to a standard single-mode fiber, an intrinsic Fabry-Perot cavity was formed inside the photonic crystal fiber. Sensing experiment results show that the sensor can work stably for a consecutive 24 h under temperatures up to 1100 °C, and the short-term operation temperature can reach as high as 1200 °C (<30 min)...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29343415/paradigms-for-restoration-of-somatosensory-feedback-via-stimulation-of-the-peripheral-nervous-system
#8
REVIEW
Cristian Pasluosta, Patrick Kiele, Thomas Stieglitz
The somatosensory system contributes substantially to the integration of multiple sensor modalities into perception. Tactile sensations, proprioception and even temperature perception are integrated to perceive embodiment of our limbs. Damage of somatosensory networks can severely affect the execution of daily life activities. Peripheral injuries are optimally corrected via direct interfacing of the peripheral nerves. Recent advances in implantable devices, stimulation paradigms, and biomimetic sensors enabled the restoration of natural sensations after amputation of the limb...
December 27, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29342893/qtl-mapping-for-fiber-quality-and-yield-traits-based-on-introgression-lines-derived-from-gossypium-hirsutum-%C3%A3-g-tomentosum
#9
Ayaz Ali Keerio, Chao Shen, Yichun Nie, Muhammad Mahmood Ahmed, Xianlong Zhang, Zhongxu Lin
The tetraploid species Gossypium hirsutum is cultivated widely throughout the world with high yield and moderate fiber quality, but its genetic basis is narrow. A set of 107 introgression lines (ILs) was developed with an interspecific cross using G. hirsutumacc. 4105 as the recurrent parent and G. tomentosum as the donor parent. A specific locus amplified fragment sequencing (SLAF-seq) strategy was used to obtain high-throughput single nucleotide polymorphism (SNP) markers. In total, 3157 high-quality SNP markers were obtained and further used for identification of quantitative trait loci (QTLs) for fiber quality and yield traits evaluated in multiple environments...
January 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341492/development-of-a-bi-modal-in-situ-crosslinking-method-to-achieve-multi-factor-release-from-electrospun-gelatin
#10
Alysha P Kishan, Taneidra Walker, Nick Sears, Thomas Wilems, Elizabeth M Cosgriff-Hernandez
To better mimic native tissue microenvironments, current efforts have moved beyond single growth factor delivery to more complex multiple growth factor delivery with distinct release profiles. Electrospun gelatin, a widely investigated drug delivery vehicle, requires post-processing crosslinking techniques that generate a mesh with uniform crosslinking density, limiting the ability to deliver multiple factors at different rates. Herein, we describe a method to independently control release of multiple factors from a single electrospun gelatin mesh...
January 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29339759/optimized-chaotic-brillouin-dynamic-grating-with-filtered-optical-feedback
#11
Jianzhong Zhang, Zhuping Li, Yuan Wu, Mingjiang Zhang, Yi Liu, Mengwen Li
Chaotic Brillouin dynamic gratings (BDGs) have special advantages such as the creation of single, permanent and localized BDG. However, the periodic signals induced by conventional optical feedback (COF) in chaotic semiconductor lasers can lead to the generation of spurious BDGs, which will limit the application of chaotic BDGs. In this paper, filtered optical feedback (FOF) is proposed to eliminate spurious BDGs. By controlling the spectral width of the optical filter and its detuning from the laser frequency, semiconductor lasers with FOF operate in the suppression region of the time-delay signature, and chaotic outputs serving as pump waves are then utilized to generate the chaotic BDG in a polarization maintaining fiber...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339721/single-molecule-fret-reveals-multiscale-chromatin-dynamics-modulated-by-hp1%C3%AE
#12
Sinan Kilic, Suren Felekyan, Olga Doroshenko, Iuliia Boichenko, Mykola Dimura, Hayk Vardanyan, Louise C Bryan, Gaurav Arya, Claus A M Seidel, Beat Fierz
The dynamic architecture of chromatin fibers, a key determinant of genome regulation, is poorly understood. Here, we employ multimodal single-molecule Förster resonance energy transfer studies to reveal structural states and their interconversion kinetics in chromatin fibers. We show that nucleosomes engage in short-lived (micro- to milliseconds) stacking interactions with one of their neighbors. This results in discrete tetranucleosome units with distinct interaction registers that interconvert within hundreds of milliseconds...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29339327/the-chaperonin-cct-promotes-the-formation-of-fibrillar-aggregates-of-%C3%AE-tubulin
#13
Luis Pouchucq, Pablo Lobos-Ruiz, Gisela Araya, José María Valpuesta, Octavio Monasterio
The type II chaperonin CCT is involved in the prevention of the pathogenesis of numerous human misfolding disorders, as it sequesters misfolded proteins, blocks their aggregation and helps them to achieve their native state. In addition, it has been reported that CCT can prevent the toxicity of non-client amyloidogenic proteins by the induction of non-toxic aggregates, leading to new insight in chaperonin function as an aggregate remodeling factor. Here we add experimental evidence to this alternative mechanism by which CCT actively promotes the formation of conformationally different aggregates of γ-tubulin, a non-amyloidogenic CCT client protein, which are mediated by specific CCT-γ-tubulin interactions...
January 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29335929/computational-model-to-investigate-the-relative-contributions-of-different-neuromuscular-properties-of-tibialis-anterior-on-force-generated-during-ankle-dorsiflexion
#14
Ariba Siddiqi, Sridhar Poosapadi Arjunan, Dinesh Kant Kumar
This study describes a new model of the force generated by tibialis anterior muscle with three new features: single-fiber action potential, twitch force, and pennation angle. This model was used to investigate the relative effects and interaction of ten age-associated neuromuscular parameters. Regression analysis (significance level of 0.05) between the neuromuscular properties and corresponding simulated force produced at the footplate was performed. Standardized slope coefficients were computed to rank the effect of the parameters...
January 16, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29335803/contribution-of-transposable-elements-and-distal-enhancers-to-evolution-of-human-specific-features-of-interphase-chromatin-architecture-in-embryonic-stem-cells
#15
Gennadi V Glinsky
Transposable elements have made major evolutionary impacts on creation of primate-specific and human-specific genomic regulatory loci and species-specific genomic regulatory networks (GRNs). Molecular and genetic definitions of human-specific changes to GRNs contributing to development of unique to human phenotypes remain a highly significant challenge. Genome-wide proximity placement analysis of diverse families of human-specific genomic regulatory loci (HSGRL) identified topologically associating domains (TADs) that are significantly enriched for HSGRL and designated rapidly evolving in human TADs...
January 15, 2018: Chromosome Research
https://www.readbyqxmd.com/read/29335356/single-bursts-of-individual-granule-cells-functionally-rearrange-feed-forward-inhibition
#16
Máté Neubrandt, Viktor János Oláh, János Brunner, Endre Marosi, Ivan Soltesz, János Szabadics
The sparse single spike activity of dentate gyrus granule cells (DG GCs) is punctuated by occasional brief bursts of 3 to 7 action potentials. It is well-known that such presynaptic bursts in individual mossy fibers (MFs; axons of granule cells) are often able to discharge postsynaptic CA3 pyramidal cells due to powerful short-term facilitation. However, what happens in the CA3 network after the passage of a brief MF burst, before the arrival of the next burst or solitary spike, is not understood. Because MFs innervate significantly more CA3 interneurons than pyramidal cells, we focused on unitary MF responses in identified interneurons in the seconds-long post-burst period, using paired recordings in rat hippocampal slices...
January 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29330628/clinical-and-cn-sfemg-evaluation-of-neostigmine-test-in-myasthenia-gravis
#17
Giorgia Sciacca, Ester Reggio, Giovanni Mostile, Alessandra Nicoletti, Filippo Drago, Salvatore Salomone, Mario Zappia
Neostigmine test (NT) is a pharmacological test, demonstrating a clinical improvement in patients affected by myasthenia gravis (MG). We aim to compare clinical evaluation and neurophysiological recordings by concentric-needle single-fiber electromyography (CN-SFEMG) in response to acute administration of neostigmine in ocular and generalized MG patients. Twenty-three MG patients (10 with ocular MG and 13 with generalized MG) were evaluated before and after 90 min neostigmine 0.5-mg administration. Clinical responsiveness was assessed by MG composite (MGC) scale...
January 12, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29330360/fibre-optic-metadevice-for-all-optical-signal-modulation-based-on-coherent-absorption
#18
Angelos Xomalis, Iosif Demirtzioglou, Eric Plum, Yongmin Jung, Venkatram Nalla, Cosimo Lacava, Kevin F MacDonald, Periklis Petropoulos, David J Richardson, Nikolay I Zheludev
Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies allows the use of coherently controlled absorption in a fully fiberized and packaged switching metadevice. With this metadevice, which controls light with light in a nanoscale plasmonic metamaterial film on an optical fibre tip, we provide proof-of-principle demonstrations of logical functions XOR, NOT and AND that are performed within a coherent fibre network at wavelengths between 1530 and 1565 nm...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29329265/multiple-octave-spanning-vibration-sensing-based-on-simultaneous-vector-demodulation-of-499-fizeau-interference-signals-from-identical-ultra-weak-fiber-bragg-gratings-over-2-5-km
#19
Yi Li, Li Qian, Ciming Zhou, Dian Fan, Qiannan Xu, Yandong Pang, Xi Chen, Jianguan Tang
Multi-point vibration sensing at the low frequency range of 0.5-100 Hz is of vital importance for applications such as seismic monitoring and underwater acoustic imaging. Location-resolved multi-point sensing using a single fiber and a single demodulation system can greatly reduce system deployment and maintenance costs. We propose and demonstrate the demodulation of a fiber-optic system consisting of 500 identical ultra-weak Fiber Bragg gratings (uwFBGs), capable of measuring the amplitude, frequency and phase of acoustic signals from 499 sensing fibers covering a total range of 2...
January 12, 2018: Sensors
https://www.readbyqxmd.com/read/29329221/high-temperature-sensor-based-on-fabry-perot-interferometer-in-microfiber-tip
#20
Zhenshi Chen, Songsong Xiong, Shecheng Gao, Hui Zhang, Lei Wan, Xincheng Huang, Bingsen Huang, Yuanhua Feng, Weiping Liu, Zhaohui Li
A miniaturized tip Fabry-Perot interferometer (tip-FPI) is proposed for high-temperature sensing. It is simply fabricated for the first time by splicing a short length of microfiber (MF) to the cleaved end of a standard single mode fiber (SMF) with precise control of the relative cross section position. Such a MF acts as a Fabry-Perot (FP) cavity and serves as a tip sensor. A change in temperature modifies the length and refractive index of the FP cavity, and then a corresponding change in the reflected interference spectrum can be observed...
January 12, 2018: Sensors
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