keyword
MENU ▼
Read by QxMD icon Read
search

Single fiber

keyword
https://www.readbyqxmd.com/read/28632940/characterization-of-the-i4399m-variant-of-apolipoprotein-a-implications-for-altered-prothrombotic-properties-of-lipoprotein-a
#1
Corey A Scipione, Jackson T McAiney, Daniel J Simard, Zainab A Bazzi, Matthew Gemin, Rocco Romagnuolo, Fraser L Macrae, Robert A Ariëns, Robert A Hegele, Janeen Auld, James W Gauld, Michael B Boffa, Marlys L Koschinsky
BACKGROUND: Lipoprotein(a) (Lp(a)) is a causal risk factor for a variety of cardiovascular diseases. Apolipoprotein(a) (apo(a)), the distinguishing component of Lp(a), is homologous to plasminogen, suggesting that Lp(a) can interfere with the normal fibrinolytic functions of plasminogen. This has implications for the persistence of fibrin clots in the vasculature and hence to atherothrombotic diseases. A single nucleotide polymorphism (rs3798220) in the gene encoding apo(a) has been reported that results in an Ile to Met substitution in the protease-like domain (I4399M variant)...
June 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28632411/the-effect-of-dexamethasone-intravitreal-implant-on-retinal-nerve-fiber-layer-in-patients-diagnosed-with-branch-retinal-vein-occlusion
#2
Orhan Ayar, Atilla Alpay, Yaran Koban, Mehmet Orcun Akdemir, Serpil Yazgan, Sılay Canturk Ugurbas, Suat Hayri Ugurbas
PURPOSE: To evaluate the effect of a single dose of intravitreal dexamethasone (DEX) implant on retinal nerve fiber layer (RNFL) thickness in patients with branch retinal vein occlusion (BRVO) in a 6-month period. MATERIALS AND METHODS: This retrospective observational study included the patients with BRVO who received intravitreal DEX implant and whose assessment included the baseline RNFL thickness measurements. The data of 26 eyes of 24 patients were retrospectively analyzed...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28629822/structure-based-designed-nano-dysferlin-significantly-improves-dysferlinopathy-in-bla-j-mice
#3
Telmo Llanga, Nadia Nagy, Laura Conatser, Catherine Dial, R Bryan Sutton, Matthew L Hirsch
Dysferlinopathy is an autosomal recessive muscular dystrophy characterized by the progressive loss of motility that is caused by mutations throughout the DYSF gene. There are currently no approved therapies that ameliorate or reverse dysferlinopathy. Gene delivery using adeno-associated vectors (AAVs) is a leading therapeutic strategy for genetic diseases; however, the large size of dysferlin cDNA (6.2 kB) precludes packaging into a single AAV capsid. Therefore, using 3D structural modeling and hypothesizing dysferlin C2 domain redundancy, a 30% smaller, dysferlin-like molecule amenable to single AAV vector packaging was engineered (termed Nano-Dysferlin)...
June 16, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28628230/thread-like-cmos-logic-circuits-enabled-by-reel-processed-single-walled-carbon-nanotube-transistors-via-selective-doping
#4
Jae Sang Heo, Taehoon Kim, Seok-Gyu Ban, Daesik Kim, Jun Ho Lee, Jesse S Jur, Myung-Gil Kim, Yong-Hoon Kim, Yongtaek Hong, Sung Kyu Park
The realization of large-area electronics with full integration of 1D thread-like devices may open up a new era for ultraflexible and human adaptable electronic systems because of their potential advantages in demonstrating scalable complex circuitry by a simply integrated weaving technology. More importantly, the thread-like fiber electronic devices can be achieved using a simple reel-to-reel process, which is strongly required for low-cost and scalable manufacturing technology. Here, high-performance reel-processed complementary metal-oxide-semiconductor (CMOS) integrated circuits are reported on 1D fiber substrates by using selectively chemical-doped single-walled carbon nanotube (SWCNT) transistors...
June 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28628101/dynamic-illumination-of-spatially-restricted-or-large-brain-volumes-via-a-single-tapered-optical-fiber
#5
Ferruccio Pisanello, Gil Mandelbaum, Marco Pisanello, Ian A Oldenburg, Leonardo Sileo, Jeffrey E Markowitz, Ralph E Peterson, Andrea Della Patria, Trevor M Haynes, Mohamed S Emara, Barbara Spagnolo, Sandeep Robert Datta, Massimo De Vittorio, Bernardo L Sabatini
Optogenetics promises precise spatiotemporal control of neural processes using light. However, the spatial extent of illumination within the brain is difficult to control and cannot be adjusted using standard fiber optics. We demonstrate that optical fibers with tapered tips can be used to illuminate either spatially restricted or large brain volumes. Remotely adjusting the light input angle to the fiber varies the light-emitting portion of the taper over several millimeters without movement of the implant...
June 19, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28628096/nucleation-and-growth-of-a-bacterial-functional-amyloid-at-single-fiber-resolution
#6
Mike Sleutel, Imke Van den Broeck, Nani Van Gerven, Cécile Feuillie, Wim Jonckheere, Claire Valotteau, Yves F Dufrêne, Han Remaut
Curli are functional amyloids produced by proteobacteria like Escherichia coli as part of the extracellular matrix that holds cells together into biofilms. The molecular events that occur during curli nucleation and fiber extension remain largely unknown. Combining observations from curli amyloidogenesis in bulk solutions with real-time in situ nanoscopic imaging at the single-fiber level, we show that curli display polar growth, and we detect two kinetic regimes of fiber elongation. Single fibers exhibit stop-and-go dynamics characterized by bursts of steady-state growth alternated with periods of stagnation...
June 19, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#7
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28621982/quantum-nonlinear-optics-with-a-germanium-vacancy-color-center-in-a-nanoscale-diamond-waveguide
#8
M K Bhaskar, D D Sukachev, A Sipahigil, R E Evans, M J Burek, C T Nguyen, L J Rogers, P Siyushev, M H Metsch, H Park, F Jelezko, M Lončar, M D Lukin
We demonstrate a quantum nanophotonics platform based on germanium-vacancy (GeV) color centers in fiber-coupled diamond nanophotonic waveguides. We show that GeV optical transitions have a high quantum efficiency and are nearly lifetime broadened in such nanophotonic structures. These properties yield an efficient interface between waveguide photons and a single GeV center without the use of a cavity or slow-light waveguide. As a result, a single GeV center reduces waveguide transmission by 18±1% on resonance in a single pass...
June 2, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28621742/high-sensitivity-refractometer-based-on-reflective-smf-small-diameter-no-core-fiber-structure
#9
Guorui Zhou, Qiang Wu, Rahul Kumar, Wai Pang Ng, Hao Liu, Longfei Niu, Nageswara Lalam, Xiaodong Yuan, Yuliya Semenova, Gerald Farrell, Jinhui Yuan, Chongxiu Yu, Jie Zeng, Gui Yun Tian, Yong Qing Fu
A high sensitivity refractive index sensor based on a single mode-small diameter no core fiber structure is proposed. In this structure, a small diameter no core fiber (SDNCF) used as a sensor probe, was fusion spliced to the end face of a traditional single mode fiber (SMF) and the end face of the SDNCF was coated with a thin film of gold to provide reflective light. The influence of SDNCF diameter and length on the refractive index sensitivity of the sensor has been investigated by both simulations and experiments, where results show that the diameter of SDNCF has significant influence...
June 16, 2017: Sensors
https://www.readbyqxmd.com/read/28619686/low-dose-bmp-2-is-sufficient-to-enhance-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#10
Francesca Gunnella, Elke Kunisch, Matthias Bungartz, Stefan Maenz, Victoria Horbert, Long Xin, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Peter Hortschansky, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann
BACKGROUND CONTEXT: Bioresorbable calcium phosphate cement (CPC) may be suitable for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures. However, additional targeted delivery of osteoinductive bone morphogenetic proteins (BMPs) in the CPC may be required to counteract the augmented local bone catabolism and support complete bone regeneration. PURPOSE: The study aimed at testing an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing low-dose bone morphogenetic protein BMP-2 in a sheep lumbar osteopenia model...
June 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28617560/influence-of-vegf-bmp-2-on-the-proliferation-and-osteogenetic-differentiation-of-rat-bone-mesenchymal-stem-cells-on-plga-gelatin-composite-scaffold
#11
G An, W-B Zhang, D-K Ma, B Lu, G-J Wei, Y Guang, C-H Ru, Y-S Wang
OBJECTIVE: To investigate the influence of VEGF/BMP-2 on the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells BMSCs) on PLGA/gelatin composite scaffold. MATERIALS AND METHODS: Randomly-oriented nanofibers with different ratios of Poly Lactic-co-Glycolic Acid (PLGA)/gelatin were produced through electrospinning. The mixture of nanofibers and BMSCs was pipetted onto the surface of the scaffolds, and BMSCs/PLGA/gelatin composite was obtained...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617098/effects-of-chronic-exposure-to-mercury-and-cadmium-alone-and-in-combination-on-the-coagulation-system-of-sprague-dawley-rats
#12
Sandra Arbi, Hester Magdalena Oberholzer, Mia Jeanne Van Rooy, Chantelle Venter, Megan Jean Bester
Water contamination with heavy metals may adversely affect our health. High metal levels lead to changes in blood coagulation processes, increasing the risk for cardiovascular disease. Exposure is not limited to a single metal but usually involves a mixture of metals. In this study 24 male Sprague-Dawley rats were exposed to cadmium (Cd) and mercury (Hg), alone and in combination, for 28 days at dosages equivalent to 1000 times the World Health Organization water limits. Scanning electron microscopy analysis revealed that both metals caused platelet activation...
June 15, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28616638/piriformis-muscle-syndrome-with-assessment-of-sciatic-nerve-using-diffusion-tensor-imaging-and-tractography-a-case-report
#13
Keizo Wada, Tomohiro Goto, Tomoya Takasago, Daisuke Hamada, Koichi Sairyo
Piriformis muscle syndrome (PMS) is difficult to diagnose by objective evaluation of sciatic nerve injury. Here we report a case of PMS diagnosed by diffusion tensor imaging (DTI) and tractography of the sciatic nerve, which can assess and visualize the extent of nerve injury. The patient was a 53-year-old man with a 2-year history of continuous pain and numbness in the left leg. His symptoms worsened when sitting. Physical examination, including sensorimotor neurologic tests, the deep tendon reflex test, and the straight leg raise test, revealed no specific findings...
June 14, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28615162/characterization-of-muscle-ankyrin-repeat-proteins-in-human-skeletal-muscle
#14
Stefan G Wette, Heather K Smith, Graham D Lamb, Robyn M Murphy
Muscle Ankyrin Repeat Proteins (MARPs) are a family of titin-associated stress response molecules and putative transducers of stretch-induced signalling in skeletal muscle. In cardiac muscle, Cardiac Ankyrin Repeat Protein (CARP) and Diabetes-Related Ankyrin Repeat Protein (DARP) reportedly redistribute from binding sites on titin to the nucleus following prolonged stretch. However, it is unclear whether Ankyrin repeat-domain protein2 (Ankrd2) shows comparable stretch-induced redistribution to the nucleus. We measured in rested human skeletal muscle 1) the absolute amount of MARPs, and 2) the distribution of Ankrd2 and DARP in both single fibers and whole muscle preparations...
June 14, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28614723/single-muscle-fiber-proteomics-reveals-fiber-type-specific-features-of-human-muscle-aging
#15
Marta Murgia, Luana Toniolo, Nagarjuna Nagaraj, Stefano Ciciliot, Vincenzo Vindigni, Stefano Schiaffino, Carlo Reggiani, Matthias Mann
Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers is characterized by diverging metabolic and protein quality control adaptations. Whereas mitochondrial content declines with aging in both fiber types, glycolysis and glycogen metabolism are upregulated in slow but downregulated in fast muscle fibers. Aging mitochondria decrease expression of the redox enzyme monoamine oxidase A...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28614324/development-of-a-high-power-blue-laser-445%C3%A2-%C3%A2-nm-for-material-processing
#16
Hongze Wang, Yosuke Kawahito, Ryohei Yoshida, Yuya Nakashima, Kunio Shiokawa
A blue diode laser has a higher absorption rate than a traditional laser, while the maximum power is limited. We report the structure and laser beam profile of a 250 W high-power blue laser (445 nm) for material processing. The absorption rate of the blue laser system for the steel was 2.75 times that of a single-mode fiber laser system (1070 nm). The characteristics of the steel after laser irradiation were determined, validating the potential of this high-power blue laser for material processing, such as heat treatment and cladding...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28613241/detection-performance-improvement-of-distributed-vibration-sensor-based-on-curvelet-denoising-method
#17
Zengguang Qin, Hui Chen, Jun Chang
A curvelet denoising method has been proposed to reduce the time domain noise to improve the detection performance in the distributed fiber vibration sensing system based on phase-sensitive optical time domain reflectometry. The raw Rayleigh backscattering traces are regarded as a gray image and the random noise can be eliminated by the curvelet transform; hence, the amplitude difference induced by the external vibration can be extracted. The detection of a vibration event with 10 m spatial resolution along a 4 km single mode fiber is demonstrated...
June 14, 2017: Sensors
https://www.readbyqxmd.com/read/28612318/somatosensory-neuron-typing-with-high-coverage-single-cell-rna-sequencing-and-functional-analysis
#18
REVIEW
Changlin Li, Sashuang Wang, Yan Chen, Xu Zhang
Different physical and chemical stimuli are detected by the peripheral sensory receptors of dorsal root ganglion (DRG) neurons, and the generated inputs are transmitted via afferent fibers into the central nervous system. The gene expression profiles of DRG neurons contribute to the generation, transmission, and regulation of various somatosensory signals. Recently, the single-cell transcriptomes, cell types, and functional annotations of somatosensory neurons have been studied. In this review, we introduce our classification of DRG neurons based on single-cell RNA-sequencing and functional analyses, and discuss the technical approaches...
June 13, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28611865/dietary-modification-trial-in-community-dwelling-japanese-elderly-a-pilot-study
#19
Chika Momoki, Taeko Tsuji, Yukina Shikata, Hana Urade, Hideki Morimoto, Shinya Nakajima, Daiki Habu
BACKGROUND: This study examined the effects of 6-month nutrition education programs for community-dwelling elderly. METHODS: This study enrolled 50 community-dwelling elderly who regularly visit outpatient clinics. The programs had three goals: salt reduction, increase in dietary fiber, and adequate protein intake. Since it would be difficult for elderly to achieve all goals concurrently, a single goal was chosen by participants themselves. Anthropometric measurements, blood sampling, and assessment of dietary intake were performed at baseline, 3 months, and 6 months...
July 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28609612/diverse-supramolecular-nanofiber-networks-assembled-by-functional-low-complexity-domains
#20
Bolin An, Xinyu Wang, Mengkui Cui, Xinrui Gui, Xiuhai Mao, Yan Liu, Ke Li, Cenfeng Chu, Jiahua Pu, Susu Ren, Yanyi Wang, Guisheng Zhong, Timothy K Lu, Cong Liu, Chao Zhong
Self-assembling supramolecular nanofibers, common in the natural world, are of fundamental interest and technical importance to both nanotechnology and materials science. Despite important advances, synthetic nanofibers still lack the structural and functional diversity of biological molecules, and the controlled assembly of one type of molecule into a variety of fibrous structures with wide-ranging functional attributes remains challenging. Here, we harness the low-complexity (LC) sequence domain of fused in sarcoma (FUS) protein, an essential cellular nuclear protein with slow kinetics of amyloid fiber assembly, to construct random copolymer-like, multi-block and self-sorted supramolecular fibrous networks with distinct structural features and fluorescent functionalities...
June 13, 2017: ACS Nano
keyword
keyword
17695
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"