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https://www.readbyqxmd.com/read/27904212/functional-outcome-after-primary-hemiarthroplasty-in-three-or-four-part-proximal-humerus-fracture-a-short-term-followup
#1
Saurabh Agarwal, Ashish Rana, Rajeev K Sharma
BACKGROUND: Several modalities of treatment are being used for the management of proximal humerus fractures. Primary hemiarthroplasty in proximal humerus fracture is indicated in three or four part fracture or fracture dislocations. It is also indicated if fracture involves a large area of articular cartilage loss and viability of head is doubtful. We studied the functional outcome of hemiarthroplasty in comminuted proximal humerus fracture. MATERIALS AND METHODS: 29 patients of three or four part proximal humerus fractures, (according to Neer's classification) who underwent primary shoulder hemiarthroplasty were included in this retrospective study...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27903299/arthroscopic-arthrodesis-for-ankle-arthritis-without-bone-graft
#2
Xiaojun Duan, Liu Yang, Li Yin
BACKGROUND: Ankle arthrodesis is considered by many to be the standard operative treatment for end-stage ankle arthritis. The purpose of this study was to perform a new technique for ankle joint surface and determine the outcome for the union rates of ankle arthroscopic arthrodesis. METHODS: A total of 68 patients with posttraumatic arthritis, primary osteoarthritis, and rheumatoid arthritis were treated by ankle arthroscopic arthrodesis between May 2007 and December 2012...
December 1, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27902166/is-intramedullary-nailing-applicable-for-distal-tibial-fractures-with-ankle-joint-extension
#3
Ozan Beytemür, Cem Albay, Oktay Adanır, Serdar Yüksel, Mehmet Akif Güleç
OBJECTIVES: This study aims to evaluate the functional and radiographic results and treatment complications of AO/OTA (Arbeitsgemeinschaft fur Osteosynthesefragen/Orthopaedic Trauma Association) type 43C1 and C2 fractures treated with intramedullary nailing. PATIENTS AND METHODS: We retrospectively evaluated 35 AO/OTA type 43C1 and C2 patients (26 males, 9 females; mean age 39.8±16.9 years; range 19 to 82 years) treated with intramedullary nailing. Two interfragmentary screws out of nail were applied in 10 patients (29%), while one interfragmentary screw out of nail was applied in 17 patients (49%)...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27901071/staphylococcus-aureus-dependent-septic-arthritis-in-murine-knee-joints-local-immune-response-and-beneficial-effects-of-vaccination
#4
Alessia Corrado, Paolo Donato, Silvia Maccari, Raffaella Cecchi, Tiziana Spadafina, Letizia Arcidiacono, Simona Tavarini, Chiara Sammicheli, Donatello Laera, Andrea Guido Oreste Manetti, Paolo Ruggiero, Bruno Galletti, Sandra Nuti, Ennio De Gregorio, Sylvie Bertholet, Anja Seubert, Fabio Bagnoli, Giuliano Bensi, Emiliano Chiarot
Staphylococcus aureus is the major cause of human septic arthritis and osteomyelitis, which deserve special attention due to their rapid evolution and resistance to treatment. The progression of the disease depends on both bacterial presence in situ and uncontrolled disruptive immune response, which is responsible for chronic disease. Articular and bone infections are often the result of blood bacteremia, with the knees and hips being the most frequently infected joints showing the worst clinical outcome. We report the development of a hematogenous model of septic arthritis in murine knees, which progresses from an acute to a chronic phase, similarly to what occurs in humans...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900709/double-locking-precontoured-plating-system-for-malunited-fractures-of-the-distal-end-of-humerus
#5
L Tarallo, R Mugnai, M Rocchi, C Rovesta, F Catani
BACKGROUND: Distal humeral malunions are uncommon injuries, often associated with limited elbow motion, pain, instability, weakness, and sometimes ulnar neuritis. The complex anatomy of the elbow joint makes this condition one of the most complex elbow injuries to treat. MATERIALS AND METHODS: Four patients were treated by the same surgeon between 2011 and 2013 using a double-locking precontoured plating system for malunited intra-articular or extra-articular fractures of the distal end of the humerus...
December 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27900338/the-bridge-enhanced-anterior-cruciate-ligament-repair-bear-procedure-an-early-feasibility-cohort-study
#6
Martha M Murray, Brett M Flutie, Leslie A Kalish, Kirsten Ecklund, Braden C Fleming, Benedikt L Proffen, Lyle J Micheli
BACKGROUND: This study assessed the safety of the newly developed bridge-enhanced anterior cruciate ligament (ACL) repair (BEAR), which involves suture repair of the ligament combined with a bioactive scaffold to bridge the gap between the torn ligament ends. As the intra-articular environment is complex in its response to implanted materials, this study was designed to determine whether there would be a significant rate of adverse reaction to the implanted scaffold. HYPOTHESIS: The primary hypothesis was that the implanted scaffold would not result in a deep joint infection (arthrocentesis with positive culture) or significant inflammation (clinical symptoms justifying arthrocentesis but negative culture)...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27891409/distal-femur-locking-plate-the-answer-to-all-distal-femoral-fractures
#7
Jagandeep Singh Virk, Sudhir Kumar Garg, Parmanand Gupta, Vivek Jangira, Jagdeep Singh, Sudhir Rana
INTRODUCTION: Good results have been published by researchers with distal femur nail, dynamic condylar screw and even addition of a medial plate to a distal femur locking plate for treating distal femur fractures. By this study, we explore the capability of a distal femur locking plate to counter distal femur fractures of extra- articular, partial or intra- articular nature. Positive results have been published by various groups from all over the world. AIM: To study the functional and radiological outcome of distal femoral fractures in skeletally mature patients treated by open reduction and internal fixation with distal femur locking plate...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27876193/effect-of-adenovirus-mediated-tgf-%C3%AE-1-gene-transfer-on-the-function-of-rabbit-articular-chondrocytes
#8
Yuan Tang, Jun Xiao, Yeyang Wang, Ming Li, Zhanjun Shi
BACKGROUND: Articular chondrocytes are important in maintaining normal cartilage tissue and preventing articular degeneration. Exogenous genes have previously been transduced into articular cells using adenoviral vectors to contribute to the maintenance of cell function. This study aimed to transfer the transforming growth factor-β1 gene (TGF-β1) into rabbit articular chondrocytes by adenovirus infection to elucidate its effects on cell function. METHODS: Rabbit chondrocytes were isolated and cultured both as monolayers and three-dimensional culture systems...
November 18, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27871200/denosumab-targeting-the-rankl-pathway-to-treat-rheumatoid-arthritis
#9
Yahui Grace Chiu, Christopher T Ritchlin
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by focal pathologic bone resorption due to excessive activity of osteoclasts (OC). Receptor activator of nuclear factor kappa B ligand (RANKL) is essential for the proliferation, differentiation, and survival of OC. Denosumab (DMab) is a humanized monoclonal antibody that binds to RANKL with high affinity and blocks its subsequent association with its receptor RANK on the surface of OC precursors. Area covered: The authors review the molecular and cellular mechanisms underlying therapeutic applications of DMab, provide recent highlights on pharmacology, efficacy and safety of DMab, and discuss the potential of DMab as a novel therapeutic option for the treatment of rheumatoid arthritis...
November 30, 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27867137/minimally-invasive-internal-fixation-of-distal-femur-fractures
#10
REVIEW
Guy Piétu, Mathieu Ehlinger
Fractures of the distal femur remain a daunting challenge. Since 1970, operative treatment has been recommended. Unfortunately it is fraught with complications, and techniques have been developed to limit incidence of non-union, infection and stiffness. A soft-tissue friendly approach is the key point, with minimally invasive surgery as the ultimate goal: its biological and anatomical advantages have; been demonstrated, but clinical studies have been less convincing, being based on historical series. At present, retrograde nailing and minimally invasive percutaneous plate osteosynthesis (ideally by locking plate) are the two main techniques...
November 17, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27861209/comparison-of-percutaneous-reduction-and-pin-fixation-in-acute-and-chronic-pediatric-mallet-fractures
#11
Manoj Reddy, Christine A Ho
BACKGROUND: Although pediatric mallet fractures are more common than adult fractures, no techniques have focused on surgical fixation of pediatric mallet fractures. This study aims to describe the technique and results of percutaneous reduction and fixation in acute and chronic pediatric mallet fractures. METHODS: This is a retrospective review of 51 pediatric mallet fractures treated with percutaneous wire fixation from 2007 to 2014; 38 were acute fractures and 13 were chronic (>4 wk from injury)...
November 17, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27852648/percutaneous-reduction-and-screw-fixation-of-displaced-intra-articular-fractures-of-the-calcaneus
#12
Saran Tantavisut, Phinit Phisitkul, Brian O Westerlind, Yubo Gao, Matthew D Karam, John L Marsh
BACKGROUND: Extensile open approaches to reduce and fix intra-articular calcaneal fractures are associated with high levels of wound complications. To avoid these complications, a technique of percutaneous reduction and fixation with screws alone was developed. This study assessed the clinical outcomes, radiographs, and postoperative CT scans after operative treatment with this technique. METHODS: 153 consecutive patients with 182 intra-articular calcaneal fractures were reviewed...
November 15, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27847659/interferon-induced-focal-segmental-glomerulosclerosis
#13
Yusuf Kayar, Nuket Bayram Kayar, Nadir Alpay, Jamshid Hamdard, Iskender Ekinci, Sebnem Emegil, Rabia Bag Soydas, Birol Baysal
Behçet's disease is an inflammatory disease of unknown etiology which involves recurring oral and genital aphthous ulcers and ocular lesions as well as articular, vascular, and nervous system involvement. Focal segmental glomerulosclerosis (FSGS) is usually seen in viral infections, immune deficiency syndrome, sickle cell anemia, and hyperfiltration and secondary to interferon therapy. Here, we present a case of FSGS identified with kidney biopsy in a patient who had been diagnosed with Behçet's disease and received interferon-alpha treatment for uveitis and presented with acute renal failure and nephrotic syndrome associated with interferon...
2016: Case Reports in Nephrology
https://www.readbyqxmd.com/read/27837327/topical-versus-intravenous-tranexamic-acid-in-total-knee-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#14
Shangquan Wang, Xinxia Gao, Yan An
BACKGROUND: Tranexamic acid (TXA) is an antifibrinolytic drug used widely to prevent bleeding in total knee arthroplasty (TKA). However, there is no consensus regarding the administration routes of TXA. This meta-analysis aimed to investigate the efficacy of topical (intra-articular) versus intravenous TXA in reducing blood loss and transfusion rate in patients who underwent TKA. METHOD: We conducted a Pubmed, EMBASE, Cochrane Library, and Web of Science search for randomized controlled trials (RCTs) comparing topical versus intravenous TXA in TKA...
November 11, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27830274/silver-coated-endoprosthetic-replacement-of-the-proximal-humerus-in-case-of-tumour-is-there-an-increased-risk-of-periprosthetic-infection-by-using-a-trevira-tube
#15
Jan Schmolders, Sebastian Koob, Paul Schepers, Michael Kehrer, Sönke Percy Frey, Dieter Christian Wirtz, Peter Heinrich Pennekamp, Andreas Christian Strauss
BACKGROUND AND OBJECTIVES: The aim of our study was to evaluate if there is an increased risk of periprosthetic infection (PJI) in patients following replacement of the proximal humerus by using a modular tumour prosthesis in combination with a trevira tube. METHODS: Thirty patients were treated by using a modular tumour endoprosthesis (MUTARS®) following intra-articular resection of the proximal humerus. Fifteen patients received treatment by using a trevira tube...
November 9, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27822380/chronic-melioidosis-presenting-with-multiple-abscesses
#16
Anshul Goel, Rahul Bansal, Shweta Sharma, Suman Singhal, Ashok Kumar
Melioidosis is common in Australia and Southeast Asia and is increasingly recognized in India. It presents in various forms which are difficult to identify and often mimics suppurative infections, tuberculosis, fungal infections, malignancy and systemic rheumatic diseases. Presentation may vary from local disease to disseminated abscesses, pneumonia and sepsis. Disease is common and severe in diabetics. We describe a case of diabetic man presenting with fever, septic shock, peri-articular nodules, lung opacities and multiple abscesses in muscles for the past 3 months remaining undiagnosed...
January 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/27812778/retrospective-analysis-of-extra-articular-distal-humerus-shaft-fractures-treated-with-the-use-of-pre-contoured-lateral-column-metaphyseal-lcp-by-triceps-sparing-posterolateral-approach
#17
Yatinder Kharbanda, Yashwant Singh Tanwar, Vishal Srivastava, Vikas Birla, Ashok Rajput, Ramsagar Pandit
Management of extra-articular distal humerus fractures presents a challenge to the treating surgeon due to the complex anatomy of the distal part of the humerus and complicated fracture morphology. Although surgical treatment has shown to provide a more stable reduction and alignment and predictable return to function, it has been associated with complications like iatrogenic radial nerve palsy, infection, non-union and Implant failure. We in the present series retrospectively analysed 20 patients with extra-articular distal humerus shaft fractures surgically treated using the extra-articular distal humeral locking plate approached by the triceps-sparing posterolateral approach...
November 3, 2016: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/27784234/use-of-intra-articular-amphotericin-b-in-the-treatment-of-candida-parasilosis-and-albicans-in-prosthetic-joint-infections-pji-a-novel-approach-to-this-difficult-problem
#18
Suresh Jude Antony
Use of intra-articular antibiotics for the treatment of arthroplasty infections has gained some interest over the last few years. This method has several advantages including: lack of systemic toxicity, ease of administration, and potentially better cure rates. The treatment of fungal infections in prosthetic joint arthroplasties is problematic with high failure and recurrence rates. We present 2 patients with Candida parasilosis and Candida albicans infections within the arthroplasty that were successfully treated with a single stage revision/spacer placement in conjunction with the use of intra-articular amphotericin B...
October 26, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27781984/an-articular-spacer-for-metacarpophalangeal-fracture-the-story-of-a-crocodile-bite
#19
G Pomares, N Pauchard, F Dap, G Dautel
Choosing the best option for reconstructing comminuted joint fractures in hand surgery raises technical challenges due to the small size of the anatomical structures and the required early mobilization. Single-stage reconstructions are clearly preferable, but when the infection risk is high, two-stage alternatives are needed. We report a case of fracture of the head of the 2nd metacarpal resulting from a crocodile bite treated by implanting an articular spacer.
October 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27781977/treatment-of-unstable-distal-phalanx-fractures-by-extra-articular-dip-pinning-a-series-of-12-cases
#20
G Prunières, S Gouzou, S Facca, A-S Matheron, N Maire, J-J Hidalgo Díaz, P Liverneaux
: Unstable distal phalanx fractures are typically treated by pinning of the distal phalanx or the distal interphalangeal joint (DIP). Complications include unstable fixation, K-wire migration, septic arthritis and osteoarthritis. To limit these complications, we wanted to explore the benefits of using locked extra-articular DIP pinning. The cohort consisted of 12 patients (mean age 36.3 years) who had an extra-articular (6 cases) or intra-articular distal phalanx fracture (6 cases). All patients were treated surgically with a construct consisting of two connected K-wires: one was placed inside the shaft of the distal phalanx and the other was placed perpendicular to the middle phalanx...
October 2016: Hand Surgery and Rehabilitation
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