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Articular infection

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https://www.readbyqxmd.com/read/28051829/apophyseal-and-epiphyseal-knee-injuries-in-the-adolescent-athlete
#1
P Persiani, F M Ranaldi, A Formica, M Mariani, O Mazza, M Crostelli, C Villani
OBJECTIVES: In the context of pediatric sports injuries, the epiphyseal and apophyseal knee fractures represent rather peculiar lesions. The most frequently involved anatomical area is the knee. The peculiar function of the physis and the need to preserve their integrity, makes choosing what treatment methods to employ very important. Objective of this study is to assess the kind and the effectiveness of the most suitable treatment in the apophyseal and epiphyseal knee lesions occurring in the adolescents...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28049097/in-vivo-anti-arthritic-efficacy-of-camellia-sinensis-l-in-collagen-induced-arthritis-model
#2
Ankit Tanwar, Raman Chawla, Md Meraj Ansari, Neha, Pallavi Thakur, Ankita Singh Chakotiya, Rajeev Goel, Himanshu Ojha, M Asif, Mitra Basu, Rajesh Arora, Haider Ali Khan
BACKGROUND: Rheumatoid arthritis (RA), an autoimmune inflammatory disorder with synovial hyperplasia, destruction of cartilage, bone damage is often associated with risk of infections. Such risk could be attributed towards usage of immunosuppressive agents. Thus, the present study was undertaken to evaluate the anti-arthritic efficacy of aquo-alcoholic extract of Camellia sinensis (L.). MATERIAL AND METHODS: Dried leaves of Camellia sinensis (L.) or Cs were filtered and extracted in 1:1 aqueous: ethanol by Soxhlet apparatus followed by lyophilization and spray drying to develop amorphous powder...
December 31, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28045216/zika-virus-and-pregnancy-an-overview
#3
Newton Sérgio de Carvalho, Beatriz Freitas de Carvalho, Bruna Dóris, Evellyn Silverio Biscaia, Cyllian Arias Fugaça, Lúcia de Noronha
In May 2015, the first episodes of Zika virus infection of the Latin America were confirmed in Brazil, where currently 196 976 cases were reported. The main route of transmission occurs by Aedes mosquitoes, and the most common symptoms are maculopapular rash, fever, conjunctivitis, polyarthralgia, and periarticular edema. However, the infection is asymptomatic in 80% of the cases. The congenital infection is characterized when the transmission to the fetus occurs during pregnancy, but the mechanisms of how the virus infects the placenta remain unclear...
January 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28041772/elevated-intra-articular-cobalt-and-chromium-levels-in-mechanically-assisted-crevice-corrosion-in-metal-on-polyethylene-total-hip-arthroplasty
#4
Brian J McGrory, Abigail M Payson, Johanna A MacKenzie
BACKGROUND: Failed total hip arthroplasty (THA) caused by mechanically assisted crevice corrosion (MACC) has serious consequences such as adverse local tissue reaction (ALTR). Serum cobalt (Co) and chromium (Cr) ion levels have been used to diagnose taper corrosion, but have not been shown to be an accurate measure of the severity of MACC or associated ALTRs. Additionally, elevated serum ions are not specific in patients with multiple artificial joints. METHODS: We examined the relationship between serum and intra-articular (IA) Co and Cr levels in a cohort of 20 patients undergoing revision THA, 16 who had symptomatic MACC...
December 14, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28040880/autologous-osteochondral-transplantation-mosaicplasty-in-articular-cartilage-defects-of-the-patellofemoral-joint-retrospective-analysis-of-33-cases
#5
T Y Emre, Z Atbasi, D T Demircioglu, M Uzun, O Kose
OBJECTIVE: The purpose of this retrospective study was to evaluate the results of osteochondral autografting (mosaicplasty) in isolated articular cartilage defects of the patellofemoral joint. MATERIALS AND METHODS: Thirty-three patients who underwent mosaicplasty for patellofemoral (either patella or trochlea) cartilage defects (modified Outerbridge classification: grades III and IV) of the knee joint were retrospectively reviewed. There were 25 male and 8 female patients with a mean age of 31...
December 31, 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28026726/-intra-articular-application-of-tranexamic-acid-significantly-reduces-blood-loss-and-transfusion-requirement-in-primary-total-knee-arthroplasty
#6
J Lošťák, J Gallo, J Špička, K Langová
PURPOSE OF THE STUDY The aim of this prospective study was to investigate the effect of topical application of tranexamic acid (TXA, Exacyl) on the amount of post-operative blood loss, and blood transfusion requirement in patients undergoing primary total knee arthroplasty (TKA). Attention was paid to early complications potentially associated with TXA administration, such as haematoma, wound exudate, or knee swelling. In addition, the economic benefit of TXA treatment was also taken into account. MATERIAL AND METHODS The study included 238 patients (85 men and 153 women) who underwent primary total knee arthroplasty (TKA) at our department between January 2013 and November 2015...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28012569/efficacy-of-methylprednisolone-acetate-versus-triamcinolone-acetonide-intra-articular-knee-injection-in-patients-with-chronic-inflammatory-arthritis-a-24-week-randomized-controlled-trial
#7
Ashwani Kumar, Varun Dhir, Shefali Sharma, Aman Sharma, Surjit Singh
PURPOSE: Triamcinolone hexacetonide (TH), triamcinolone acetonide (TA), and methylprednisolone acetate (MPA) are commonly used intra-articular steroid preparations. Studies suggest that intra-articular TH is more efficacious than MPA and TA in chronic inflammatory arthritis. However, it is unclear which of the latter two preparations has better efficacy. Thus, we compared intra-articular knee injections of MPA and TA in patients with chronic inflammatory arthritis. METHODS: This double-blind, randomized controlled trial included patients with rheumatoid arthritis or spondyloarthritis with an acutely swollen knee joint (≥1 week, <24 weeks)...
December 21, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/28009702/volar-dorsal-and-lateral-locking-plate-fixation-for-pilon-fractures
#8
Mark Henry
The more common dorsal fracture subluxations at the base of the middle phalanx have an intact dorsal buttress of articular surface in continuity with the shaft. Capitalizing on this foundation, various fixation methods have met with relatively equivalent success including Kirschner wires, screws only, nonlocking plate and screws, and external fixation. Pilon fractures are complete articular fractures, where the comminuted articular fragments lack any structural connection to the more distal shaft of the middle phalanx, and have largely relied upon external fixation traction systems...
December 22, 2016: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/27992643/recall-of-the-asr-xl-head-and-hip-resurfacing-systems
#9
Werner Maurer-Ertl, Joerg Friesenbichler, Lukas A Holzer, Lukas Leitner, Kathrin Ogris, Michael Maier, Andreas Leithner
At the beginning of the 21st century, use of large-diameter, metal-on-metal devices was a popular procedure for hip replacement in young and physically active patients; however, within a few years, the number of revisions increased, resulting in a worldwide recall for the articular surface replacement (ASR) system. Complication rates for the ASR devices implanted at the authors' department are reported, with revision rates of 32% and 30% in the ASR XL Head and ASR Resurfacing groups, respectively. Reasons for revision surgery were serum metal ion elevation, luxation or subluxation, aseptic loosening, soft tissue compromise (adverse reactions to metal debris [ARMD]), and infection...
December 19, 2016: Orthopedics
https://www.readbyqxmd.com/read/27956598/the-lyme-disease-pathogen-borrelia-burgdorferi-infects-murine-bone-and-induces-trabecular-bone-loss
#10
Tian Tian Tang, Lucia Zhang, Anil Bansal, Marc Grynpas, Tara J Moriarty
Lyme disease is caused by members of the Borrelia burgdorferi sensu lato species complex. Arthritis is a well-known late-stage pathology of Lyme disease, but the effects of B. burgdorferi infection on bone at sites other than articular surfaces are largely unknown. In this study, we investigated whether B. burgdorferi infection affects bone health in mice. In mice inoculated with B. burgdorferi or vehicle (mock infection), we measured the presence of B. burgdorferi DNA in bones, bone mineral density (BMD), bone formation rates, biomechanical properties, cellular composition, and two- and three-dimensional features of bone microarchitecture...
December 12, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27924736/-septic-arthritis-after-intra-articular-injection-is-rare-does-the-taskforce-infection-prevention-use-a-sledgehammer-to-crack-a-nut
#11
M L Bruens, H J van der Zaag-Loonen, F Steenstra, A M Stemerding, S Wijngaarden
OBJECTIVE: To determine the incidence of septic arthritis (SA) after a joint puncture and reconsider the value of the hygiene measures stipulated by the Taskforce Infection Prevention (TIF). DESIGN: Prospective study. METHOD: We determined the number of joint punctures among general practitioners and specialists in the Apeldoorn area during a three-month period (from October 1, 2013 to December 31, 2013). Secondly, we performed an analysis on the incidence of SAs in this period and the subsequent month, and ascertained if these were related to a joint puncture...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27907047/rage-deficiency-impairs-bacterial-clearance-in-murine-staphylococcal-sepsis-but-has-no-significant-impact-on-staphylococcal-septic-arthritis
#12
Majd Mohammad, Manli Na, Amanda Welin, Mattias N D Svensson, Abukar Ali, Tao Jin, Rille Pullerits
BACKGROUND: Septic arthritis is a serious joint disease often caused by Staphylococcus aureus (S. aureus). Receptor for Advanced Glycation End products (RAGE) has an important role in several infections. We sought to investigate the role of RAGE in staphylococcal septic arthritis and sepsis in mice. METHODS: Wild-type (WT) and RAGE deficient (RAGE-/-) mice were intra-articularly or intravenously inoculated with an arthritic or septic dose of S. aureus LS-1 strain...
2016: PloS One
https://www.readbyqxmd.com/read/27904212/functional-outcome-after-primary-hemiarthroplasty-in-three-or-four-part-proximal-humerus-fracture-a-short-term-followup
#13
Saurabh Agarwal, Ashish Rana, Rajeev K Sharma
BACKGROUND: Several modalities of treatment are being used for the management of proximal humerus fractures. Primary hemiarthroplasty in proximal humerus fracture is indicated in three or four part fracture or fracture dislocations. It is also indicated if fracture involves a large area of articular cartilage loss and viability of head is doubtful. We studied the functional outcome of hemiarthroplasty in comminuted proximal humerus fracture. MATERIALS AND METHODS: 29 patients of three or four part proximal humerus fractures, (according to Neer's classification) who underwent primary shoulder hemiarthroplasty were included in this retrospective study...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27903299/arthroscopic-arthrodesis-for-ankle-arthritis-without-bone-graft
#14
Xiaojun Duan, Liu Yang, Li Yin
BACKGROUND: Ankle arthrodesis is considered by many to be the standard operative treatment for end-stage ankle arthritis. The purpose of this study was to perform a new technique for ankle joint surface and determine the outcome for the union rates of ankle arthroscopic arthrodesis. METHODS: A total of 68 patients with posttraumatic arthritis, primary osteoarthritis, and rheumatoid arthritis were treated by ankle arthroscopic arthrodesis between May 2007 and December 2012...
December 1, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27902166/is-intramedullary-nailing-applicable-for-distal-tibial-fractures-with-ankle-joint-extension
#15
Ozan Beytemür, Cem Albay, Oktay Adanır, Serdar Yüksel, Mehmet Akif Güleç
OBJECTIVES: This study aims to evaluate the functional and radiographic results and treatment complications of AO/OTA (Arbeitsgemeinschaft fur Osteosynthesefragen/Orthopaedic Trauma Association) type 43C1 and C2 fractures treated with intramedullary nailing. PATIENTS AND METHODS: We retrospectively evaluated 35 AO/OTA type 43C1 and C2 patients (26 males, 9 females; mean age 39.8±16.9 years; range 19 to 82 years) treated with intramedullary nailing. Two interfragmentary screws out of nail were applied in 10 patients (29%), while one interfragmentary screw out of nail was applied in 17 patients (49%)...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27901071/staphylococcus-aureus-dependent-septic-arthritis-in-murine-knee-joints-local-immune-response-and-beneficial-effects-of-vaccination
#16
Alessia Corrado, Paolo Donato, Silvia Maccari, Raffaella Cecchi, Tiziana Spadafina, Letizia Arcidiacono, Simona Tavarini, Chiara Sammicheli, Donatello Laera, Andrea Guido Oreste Manetti, Paolo Ruggiero, Bruno Galletti, Sandra Nuti, Ennio De Gregorio, Sylvie Bertholet, Anja Seubert, Fabio Bagnoli, Giuliano Bensi, Emiliano Chiarot
Staphylococcus aureus is the major cause of human septic arthritis and osteomyelitis, which deserve special attention due to their rapid evolution and resistance to treatment. The progression of the disease depends on both bacterial presence in situ and uncontrolled disruptive immune response, which is responsible for chronic disease. Articular and bone infections are often the result of blood bacteremia, with the knees and hips being the most frequently infected joints showing the worst clinical outcome. We report the development of a hematogenous model of septic arthritis in murine knees, which progresses from an acute to a chronic phase, similarly to what occurs in humans...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900709/double-locking-precontoured-plating-system-for-malunited-fractures-of-the-distal-end-of-humerus
#17
L Tarallo, R Mugnai, M Rocchi, C Rovesta, F Catani
BACKGROUND: Distal humeral malunions are uncommon injuries, often associated with limited elbow motion, pain, instability, weakness, and sometimes ulnar neuritis. The complex anatomy of the elbow joint makes this condition one of the most complex elbow injuries to treat. MATERIALS AND METHODS: Four patients were treated by the same surgeon between 2011 and 2013 using a double-locking precontoured plating system for malunited intra-articular or extra-articular fractures of the distal end of the humerus...
December 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27900338/the-bridge-enhanced-anterior-cruciate-ligament-repair-bear-procedure-an-early-feasibility-cohort-study
#18
Martha M Murray, Brett M Flutie, Leslie A Kalish, Kirsten Ecklund, Braden C Fleming, Benedikt L Proffen, Lyle J Micheli
BACKGROUND: This study assessed the safety of the newly developed bridge-enhanced anterior cruciate ligament (ACL) repair (BEAR), which involves suture repair of the ligament combined with a bioactive scaffold to bridge the gap between the torn ligament ends. As the intra-articular environment is complex in its response to implanted materials, this study was designed to determine whether there would be a significant rate of adverse reaction to the implanted scaffold. HYPOTHESIS: The primary hypothesis was that the implanted scaffold would not result in a deep joint infection (arthrocentesis with positive culture) or significant inflammation (clinical symptoms justifying arthrocentesis but negative culture)...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27891409/distal-femur-locking-plate-the-answer-to-all-distal-femoral-fractures
#19
Jagandeep Singh Virk, Sudhir Kumar Garg, Parmanand Gupta, Vivek Jangira, Jagdeep Singh, Sudhir Rana
INTRODUCTION: Good results have been published by researchers with distal femur nail, dynamic condylar screw and even addition of a medial plate to a distal femur locking plate for treating distal femur fractures. By this study, we explore the capability of a distal femur locking plate to counter distal femur fractures of extra- articular, partial or intra- articular nature. Positive results have been published by various groups from all over the world. AIM: To study the functional and radiological outcome of distal femoral fractures in skeletally mature patients treated by open reduction and internal fixation with distal femur locking plate...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27876193/effect-of-adenovirus-mediated-tgf-%C3%AE-1-gene-transfer-on-the-function-of-rabbit-articular-chondrocytes
#20
Yuan Tang, Jun Xiao, Yeyang Wang, Ming Li, Zhanjun Shi
BACKGROUND: Articular chondrocytes are important in maintaining normal cartilage tissue and preventing articular degeneration. Exogenous genes have previously been transduced into articular cells using adenoviral vectors to contribute to the maintenance of cell function. This study aimed to transfer the transforming growth factor-β1 gene (TGF-β1) into rabbit articular chondrocytes by adenovirus infection to elucidate its effects on cell function. METHODS: Rabbit chondrocytes were isolated and cultured both as monolayers and three-dimensional culture systems...
November 18, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
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