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https://www.readbyqxmd.com/read/29785926/intramedullary-nail-fixation-versus-locking-plate-fixation-for-adults-with-a-fracture-of-the-distal-tibia-the-uk-fixdt-rct
#1
Matthew L Costa, Juul Achten, Susie Hennings, Nafisa Boota, James Griffin, Stavros Petrou, Mandy Maredza, Melina Dritsaki, Thomas Wood, James Masters, Ian Pallister, Sarah E Lamb, Nick R Parsons
BACKGROUND: The best treatment for fractures of the distal tibia remains controversial. Most of these fractures require surgical fixation, but the outcomes are unpredictable and complications are common. OBJECTIVES: To assess disability, quality of life, complications and resource use in patients treated with intramedullary (IM) nail fixation versus locking plate fixation in the 12 months following a fracture of the distal tibia. DESIGN: This was a multicentre randomised trial...
May 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29785313/management-of-an-infected-nonunion-of-an-opening-wedge-high-tibial-osteotomy-with-2-stage-implantation-of-rotating-hinge-knee-prosthesis
#2
Sandrine Mariaux, Olivier Borens
Introduction: High tibial osteotomy (HTO) is a frequent and effective treatment for unicompartmental gonarthritis. Only a few articles are focused on the treatment of infected nonunion. Patient and Method: A 50-year-old obese patient was operated on by medial opening-wedge HTO. She developed a painful nonunion treated by hardware removal, allograft, and plate fixation. However, the nonunion persisted. 2 years later, cellulitis appeared with an abscess adjacent to the HTO plate...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29772993/shoulder-lesion-in-a-69-year-old-woman
#3
Andrew J Hayden, Srinivas Kolla, Adele L Boskey, Steven Burekhovich, Chuanyong Lu, Michael Stracher, Aditya V Maheshwari
Milwaukee Shoulder Syndrome (MSS) is a painful progressive arthropathy in which hydroxyapatite crystal deposition in synovial tissue induces lysosomal release of collagenase and neutral proteases. These enzymes are destructive to periarticular tissue, including the synovium, articular cartilage, rotator cuff muscles, and the intrasynovial cortical bone. MSS predominantly occurring in women (90%) over the age of 70 years of age with a clinical history marked by recurrent joint effusions and pain, which classically worsens at night...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29770583/angle-stable-interlocking-intramedullary-nails-for-tibial-plateau-fractures
#4
Peng Jia, Feng-Cheng Lu, Kifayat Ullah, Man Zhang, Yan-Sheng Dong, Chao Xiong, Zhi-Hui Zhao, Jin-Feng Wang, Ju-Wen Chen, Yong-Qing Wang
OBJECTIVE: Angle stable interlocking intramedullary nail (ASIN), a novel technique, has rarely been used for treatment of tibial plateau fractures (TPF). This retrospective study was designed to introduce this novel technique, ASIN, as well as to describe the initial experience and verify the effectiveness when ASIN was used for the management for TPF. METHODS: A cohort of 19 cases with closed TPF aged from 18-70 years with at least 23 months follow-up from November 2008 to September 2013 was analyzed retrospectively...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29755914/supracondylar-humeral-fractures-an-audit-of-the-frequency-of-bi-columnar-fixation-and-intra-articular-wire-placement
#5
Andrew Ker, Claire Murnaghan, James S Huntley
Introduction For supracondylar humeral (SCH) fractures, biomechanical studies suggest the most stable wire configuration achieves bi-columnar fixation. Achieving medial column fixation using lateral-entry-only wires may require an intracapsular entry point. The aim of this study was to identify the rate of bi-columnar fixation achieved in our department when treating SCH fractures with percutaneous wire fixation. A secondary aim was to identify the rate of placement of an intra-articular wire. Further aims were to examine if failure to achieve bi-columnar fixation was associated with an increased loss of fixation and whether the placement of an intra-articular wire resulted in any cases of deep infection or septic arthritis...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29738401/locking-plate-fixation-in-a-series-of-bicondylar-tibial-plateau-fractures-raises-treatment-costs-without-clinical-benefit
#6
Matthew Cavallero, Richard Rosales, Jesse Caballero, Laurence B Kempton, Walter W Virkus, Greg E Gaski
OBJECTIVES: To compare outcomes and costs between locking and nonlocking constructs in the treatment of bicondylar tibial plateau (BTP) fractures. DESIGN: Retrospective cohort study. SETTING: Level 1 academic trauma center. PATIENTS: All patients that presented with complete articular, BTP fractures (AO/OTA 41-C and Schatzker 6) between 2013-2015 were screened (n=112). Patients treated with a mode of fixation other than plate-and-screw were excluded...
May 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29735339/distal-medial-tibial-locking-plate-for-fixation-of-extraarticular-distal-humeral-fractures-an-alternative-choice-for-fixation
#7
Ali Cagdas Yorukoglu, Ahmet Fahir Demirkan, Nihal Buker
OBJECTIVE: The aim of this study was to describe an alternative fixation method for distal humeral extra-articular fractures through posterior approach using distal tibia anatomic locking plate; and to evaluate the patient's functional outcome and union condition. METHODS: Eighteen patients (11 men and 7 women; average age of 37.0 ± 17.3 years (range: 18-73 years)) with a distal humeral extra-articular fracture who were treated with distal tibial medial locking plate were included into the study...
May 4, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29729165/modern-specific-features-and-therapy-of-psoriasis-and-arthropathic-psoriasis-courses
#8
Orysya O Syzon, Marianna O Dashko, Ulyana V Fedorova
OBJECTIVE: Introduction:Psoriasis affects about 2% of population. In 30-40% of occurrences arthropathic psoriasis (AP) is diagnosed and it leads to 11-19% of disability cases development. Recent studies have shown that psoriasis is often synergistically combined with herpesvirus of the 1st and 2nd type, which, according to many scientists, determines the severity, frequency of recurrences, and the course of this dermatosis. Recently, new biomarkers, i.e. a system of small ribonucleic microRNA acids, have been described...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29713837/current-options-and-emerging-biomaterials-for-periprosthetic-joint-infection
#9
REVIEW
Ashley E Levack, Erika L Cyphert, Mathias P Bostrom, Christopher J Hernandez, Horst A von Recum, Alberto V Carli
PURPOSE OF REVIEW: Infection in the setting of total joint arthroplasty, referred to as periprosthetic joint infection (PJI), is a devastating complication requiring prolonged and costly treatment. The unique environment around an artificial joint and ability of surrounding tissues to sequester bacteria collectively make prevention, diagnosis, and treatment of this condition challenging. In light of the unique pathogenesis of PJI, this review explores the limitations of contemporary treatments and discusses novel treatment options...
April 30, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29706728/acute-arthrodesis-of-interphalangeal-joints-of-the-hand-in-traumatic-injuries
#10
Mark Tan, Sean Wei Loong Ho, Sreedharan Sechachalam
Background: Trauma resulting in severe comminution, bone loss, and articular involvement of the fingers is a challenging injury. Osteosynthesis of the digits is nonviable when there is an inability to restore a stable articular surface adequately. Acute arthrodesis of the proximal and distal interphalangeal joints may be an option in such scenarios. The aim of this study is to evaluate the role of finger joint arthrodesis in the setting of trauma, in terms of fusion rates and clinical outcomes...
April 2018: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/29705681/midlevel-constraint-without-stem-extensions-in-primary-total-knee-arthroplasty-provides-stability-without-compromising-fixation
#11
David A Crawford, Jesua I Law, Adolph V Lombardi, Keith R Berend
BACKGROUND: Many total knee arthroplasty (TKA) systems allow for so-called midlevel constraint (MLC) articular bearings that can be used with primary implants. The purpose of this study is to report the early outcomes with MLC bearings in primary TKA. MATERIALS/METHODS: From December 2005 to June 2015, minimum 2-year follow-up was available on 96 patients (103 TKA) who underwent primary TKA with an MLC bearing using the Vanguard Total Knee System. Outcomes included pain, Knee Society clinical and functional score, range of motion, and need for revision...
April 9, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29703609/persistent-arthralgia-and-related-risks-factors-a-cohort-study-at-12-months-from-laboratory-confirmed-chikungunya-infection
#12
Efrén Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, José Guzmán-Esquivel, Enrique Higareda-Almaraz, Martha Alicia Higareda-Almaraz, Ramón Alberto Sánchez-Piña, Agustin Lugo-Radillo
AIM OF THE STUDY: To assess the cumulative incidence and clinical markers associated with persistent arthralgia (PA) at 12 months from acute chikungunya virus (CHIKV) infection. METHODS: A multicenter retrospective cohort study was conducted in the state of Colima, Mexico, and 217 serologically confirmed cases of CHIKV infection were enrolled. Participants aged 15 years and older were interviewed on 6 months basis from acute illness onset and the main binary outcome was self-reported PA at 12 months...
April 24, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29701699/simultaneous-determination-of-decursin-decursinol-angelate-nodakenin-and-decursinol-of-angelica-gigas-nakai-in-human-plasma-by-uhplc-ms-ms-application-to-pharmacokinetic-study
#13
Sook-Jin Kim, Se-Mi Ko, Eun-Jeong Choi, Seong-Ho Ham, Young-Dal Kwon, Yong-Bok Lee, Hea-Young Cho
Coumarins in Cham-dang-gwi, the dried root of Angelica gigas Nakai (AGN), possess pharmacological effects on anemia, pain, infection, and articular rheumatism. The AGN root containes decursin (D), decursinol angelate (DA), nodakenin, and decursinol (DOH), a major metabolite of D and DA. The aim of this study was to develop a simultaneous determination method for these four coumarins in human plasma using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Chromatographic separation was performed on dual columns (Kinetex® C18 column and Capcell core C18 column) with mobile phase consisting of water and acetonitrile at a flow rate of 0...
April 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29701099/management-of-extra-articular-segmental-defects-in-long-bone-using-a-titanium-mesh-cage-as-an-adjunct-to-other-methods-of-fixation
#14
N Attias, A M Thabet, G Prabhakar, J A Dollahite, R J Gehlert, T A DeCoster
Aims This study reviews the use of a titanium mesh cage (TMC) as an adjunct to intramedullary nail or plate reconstruction of an extra-articular segmental long bone defect. Patients and Methods A total of 17 patients (aged 17 to 61 years) treated for a segmental long bone defect by nail or plate fixation and an adjunctive TMC were included. The bone defects treated were in the tibia (nine), femur (six), radius (one), and humerus (one). The mean length of the segmental bone defect was 8.4 cm (2.2 to 13); the mean length of the titanium mesh cage was 8...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29700991/a-new-treatment-modality-for-rheumatoid-arthritis-combined-photothermal-and-photodynamic-therapy-using-cu-7-2-s-4-nanoparticles
#15
Yao Lu, Lihua Li, Zefeng Lin, Liping Wang, Lijun Lin, Mei Li, Yu Zhang, Qingshui Yin, Qi Li, Hong Xia
Rheumatoid arthritis (RA) is a worldwide inflammatory disease that seriously threatens human health and needs more effective treatment approaches. Near infrared (NIR) light can efficiently penetrate inflamed joints affected by RA, so phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), may provide new opportunities. In this work, the unique Cu7.2 S4 nanoparticles (NPs) are prepared for RA treatment enlightened by the fact that copper (Cu)-based nanomaterials can simultaneously serve as PTT agents and photosensitizers (for PDT)...
April 26, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29696285/the-role-of-sox9-in-collagen-hydrogel-mediated-chondrogenic-differentiation-of-adult-mesenchymal-stem-cells-mscs
#16
Xianfang Jiang, Xianyuan Huang, Tongmeng Jiang, Li Zheng, Jinmin Zhao, Xingdong Zhang
Sox9 is a transcription factor that regulates chondrogenesis, but its role in the chondrogenic differentiation of mesenchymal stem cells (MSCs) triggered by materials is poorly understood. In this study, we investigated the effect of Sox9 interference on collagen-induced chondrogenesis and further collagen-based therapies for cartilage defects. In this paper, MSCs were infected with a vector carrying the Sox9 promoter and related markers were detected. A lentivirus-mediated vector targeting the silencing of the Sox9 gene was used in bone marrow-derived MSCs prior to being encapsulated in a collagen hydrogel...
April 26, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29625614/a-novel-implant-removal-technique-by-endoscopy
#17
Chang Heng Liu, Wen Lin Yeh, Ping Jui Tsai, Kuo Feng Fan, Hung Wei Cheng, Jian Ming Chen
BACKGROUND: Routine implant removal after fracture healing remains controversial. However, it has been suggested that implant removal should be performed in cases of joint impingement, painful scar adhesion, and implant malposition. Entrance selection is relatively critical in patients with poor soft tissue conditions or sloughing coverage. We propose an innovative technique using endoscopy. METHODS: Consecutive surgeries of endoscopic implant removal performed between 2005 and 2016 by a single experienced arthroscopic surgeon were included...
April 6, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29600202/late-and-vague-presentation-of-septic-arthritis-of-hip-in-a-ivdrug-abuser
#18
Anantha Krishnan Raghupathi, Avinash Joshi
Introduction: Septic arthritis of the hip is a rare entity in acute presentation of hip pain in adults. Even though hip is the second most commonly affected joint, adult patients with septic arthritis not related to a surgical procedure represent <0.00001% of total acute admissions. Case Report: We present a 32-year-old female intravenous drug abuser, positive for Hepatitis B and C who had started to inject her femoral veins 2 years ago. She presented with a 10 weeks history of radiating pain in the leg which was full, constant and diffuse in nature with hip stiffness...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29587603/fractures-at-the-junction-of-diaphysis-and-metaphysis-of-the-proximal-phalanges-in-adults
#19
David J Shewring, Ryan W Trickett, Adam Smith
We describe the treatment of 101 patients with 113 fractures of the proximal phalanx at the junction of the diaphysis with the proximal metaphysis. Fractures were stabilized using a single extra-articular percutaneous Kirschner wire passed lateral to the metacarpal head into the base of the phalanx base and across the fracture to engage the lateral cortex. Patients were treated semi-electively on a day surgery unit. The metacarpophalangeal joint was splinted in flexion with mobilization of the proximal inter-phalangeal joints, until the wire was removed at 24 days and the hand then freely mobilized...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29570764/atypical-mycobacterial-infections-of-the-upper-extremity
#20
Kevin P Smidt, Peter J Stern, Thomas R Kiefhaber
Atypical mycobacterial infections of upper extremity synovial-lined structures are often misdiagnosed and unrecognized. Despite an increasing incidence, lack of physician awareness of these pathogens may result in considerable delay in diagnosis and management, potentially leading to permanent disability. The authors conducted a literature review and analyzed 31 cases of penetrating atypical mycobacterial infection to better understand the clinical characteristics and to evaluate their posttreatment complication rate compared with available literature...
March 23, 2018: Orthopedics
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