Soumyadeep Sarkar, Cailin Deiter, Jennifer E Kyle, Michelle A Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L Eizirik, Bobbie-Jo M Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O Metz, Raghavendra G Mirmira, Lori Sussel, Charles Ansong, Ernesto S Nakayasu
BACKGROUND: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-cell death. METHODS: We performed lipidomics using three models of insulitis: human islets and EndoC-βH1 β cells treated with the pro-inflammatory cytokines interlukine-1β and interferon-γ, and islets from pre-diabetic non-obese mice...
February 21, 2024: Cell Communication and Signaling: CCS