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https://www.readbyqxmd.com/read/29755784/butin-attenuates-brain-edema-in-a-rat-model-of-intracerebral-hemorrhage-by-anti-inflammatory-pathway
#1
Peiyu Li, Cheng Jiwu
Background: This study evaluates the effect of butin against brain edema in intracerebral hemorrhage (ICH). Methodology: ICH was induced by injecting bacterial collagenase in the brain and all the animals were separated into four groups such as control group, ICH group treated with vehicle, Butin 25 and 50 mg/kg group receives butin (25 and 50 mg/kg, i.p.)60 min after the induction of ICH in all animals. One day after neurological score, hemorrhagic injury and expressions of protein responsible for apoptosis and inflammatory cytokines were assessed in the brain tissue of ICH rats...
2018: Translational Neuroscience
https://www.readbyqxmd.com/read/29752894/d-pinitol-attenuates-cisplatin-induced-nephrotoxicity-in-rats-impact-on-pro-inflammatory-cytokines
#2
Nita Vasaikar, Umesh Mahajan, Kalpesh R Patil, Kapil Suchal, Chandragouda R Patil, Shreesh Ojha, Sameer N Goyal
Cisplatin has been widely used as a first-line agent against various forms of solid cancers. However, nephrotoxicity is the major limiting factor for its clinical use. Several clinical and pre-clinical studies have suggested different strategies for the reduction of cisplatin-induced nephrotoxicity. The present study was conducted to investigate the efficacy of D-Pinitol, against cisplatin-induced nephrotoxicity in Swiss albino mice. A single intraperitoneal injection of cisplatin (20 mg/kg) was used to induce nephrotoxicity in mice...
May 9, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29740252/beneficial-effect-of-daidzin-in-dry-eye-rat-model-through-the-suppression-of-inflammation-and-oxidative-stress-in-the-cornea
#3
Fan Xiao, Hua Cui, Xiao Zhong
Present investigation evaluates the effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea. Briefly, electron spine resonance was used for the estimation of radical scavenging activity of daidzin and COX Fluorescent Activity Assay Kit was used for the estimation of PGS activity. Dry eye rat model was developed by removing the lacrimal gland and effect of daidzin was evaluated in dry eye rat model by estimating the fluorescein score, tear volume and expressions of heme oxigenase (HO-1), TNF α, Interlukin 6 (IL-6), matrix metallopeptidase 9 (MMP-9) and PGS-2...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29592781/no-requirement-of-interlukine-1-for-long-term-potentiation-in-the-anterior-cingulate-cortex-of-adult-mice
#4
Jing-Shan Lu, Qian Song, Ming-Ming Zhang, Min Zhuo
Background The enhanced expression of cytokines in the pathological states suggests that they have important roles in the initiation or maintenance of disease states. FINDINGS: To determine the involvement of cytokines in chronic neuropathic pain, the expression of cytokines in the anterior cingulate cortex neurons in the ligation of the common peroneal nerve mice was investigated. We utilized a cytokine enzyme-linked immunosorbent assay plate array to detect 23 cytokines in total eight mice including a female, and no significant differences were found in those cytokines between the common peroneal nerve model and sham surgery mice...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29574938/resolvin-e1-r-v-e-1-attenuates-lps-induced-inflammation-and-subsequent-atrophy-in-c2c12-myotubes
#5
Luke A Baker, Neil R W Martin, Marc C Kimber, Gareth J Pritchard, Martin R Lindley, Mark P Lewis
Resolution of inflammation is now known to be an active process which in part is instigated and controlled by specialized pro-resolving lipid mediators (SPM's) derived from dietary omega-3 fatty acids. Resolvin E1 (Rv E1 ) is one of these SPM's derived from the omega-3 fatty acid eicosapentaenoic acid. Using both molecular and phenotypic functional measures we report that in a model of Lipopolysaccharide (LPS) induced inflammation, Rv E1 attenuated mRNA levels of both interlukin-6 and monocyte chemoattractant protein-1 whilst having no effect on tumor necrosis factor-α or interlukin-1β in C2C12 skeletal muscle myotubes...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29558631/combined-treatment-with-interlukin-1-and-tumor-necrosis-factor-alpha-antagonists-improve-type-2-diabetes-in-rats
#6
Burak DiK, Emre Bahcivan, Hatice Eser Faki, Kamil Uney
In the present study, combined treatment with etanercept and anakinra were tested in the streptozotocin-induced diabetic rats. Forty male Wistar albino rats were divided into 5 groups; healthy control (HC), diabetic control (DC), diabetic+anakinra (DAT), diabetic+etanercept (DET), and diabetic+etanercept+anakinra (DEAT). HC and DC groups received subcutaneous (sc.) injection with a saline solution, while DAT and DET groups received anakinra (10 mg/kg/day, sc.) or etanercept (10 mg/kg, twice a week, sc.), and DEAT rats received both anakinra and etanercept treatments for 21 days after diabetes has developed...
March 20, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29557530/neuroprotective-efficiency-of-mangifera-indica-leaves-extract-on-cadmium-induced-cortical-damage-in-rats
#7
Naif E Al Omairi, Omyma K Radwan, Yahea A Alzahrani, Rami B Kassab
Due to the high ability of cadmium to cross the blood-brain barrier, cadmium (Cd) causes severe neurological damages. Hence, the purpose of this study was to investigate the possible protective effect of Mangifera indica leaf extract (MLE) against Cd-induced neurotoxicity. Rats were divided into eight groups. Group 1 served as vehicle control group, groups 2, 3 and 4 received MLE (100, 200, 300 mg /kg b.wt, respectively). Group 5 was treated with CdCl2 (5 mg/kg b.wt). Groups 6, 7 and 8 were co-treated with MLE and CdCl2 using the same doses...
March 20, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29477033/involvement-of-thromboxane-a-2-in-interleukin-31-induced-itch-associated-response-in-mice
#8
Tsugunobu Andoh, Sikai Li, Daisuke Uta
BACKGROUND: Atopic dermatitis is a chronic and severe pruritic skin disease. Interlukin-31 (IL-31) has been recently demonstrated to be one of the key pruritogens in atopic dermatitis. However, the mechanisms underlying IL-31-induced itching remains unclear. In our previous study, we have shown that thromboxane (TX) A2 is involved in itch-associated responses in mice with atopy-like skin diseases. METHODS: IL-31 was given intradermally into the rostral back of ICR mice and the hind-paw scratching to the injection site were counted...
April 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29429072/an-ex-vivo-ruminal-ovine-model-to-study-the-immediate-immune-response-in-the-context-of-bacterial-lipopolysaccharide
#9
Fathi Abouhajer, Saeed El-Ashram, Musafiri Karama, Shujian Huang, Jian-Feng Liu
We have set up an ex vivo ovine ruminal model, which can mimic the multicellular process to explore the early steps in Salmonella typhimurium lipopolysaccharide (LPS) stimulation using RNA-seq technology. Ovine ruminal explants were collected for histological and transcriptional analysis and supernatants collected to quantitate lactate dehydrogenase (LDH) enzymes. A total of 8 and 523 genes were significantly over-expressed between LPS-treated and control tissues at 6 and 12 h, respectively. However, six and seven hundred and thirteen genes were substantially repressed between the aforementioned tissues, correspondingly...
May 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29392796/micro-inflammation-in-functional-dyspepsia-a-systematic-review-and-meta-analysis
#10
REVIEW
L Du, B Chen, J J Kim, X Chen, N Dai
Functional dyspepsia (FD) is a gastrointestinal disorder of unknown etiology. Although micro-inflammation appears to be important in the pathogenesis, studies evaluating immune activation in FD have been inconsistent. A systematic review of literature and meta-analysis was performed to compare immunologic cell counts and cytokine levels in the mucosa and peripheral blood of individuals with FD and healthy controls. PubMed, Embase, and the Cochrane library were searched. Data on immunologic cell counts and cytokines levels among individuals with FD and control groups were extracted and compared by calculating standard mean differences (SMD)...
April 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29389569/functional-components-in-scutellaria-barbata-d-don-with-anti-inflammatory-activity-on-raw-264-7-cells
#11
Hsin-Lan Liu, Tsai-Hua Kao, Chyuan-Yuan Shiau, Bing-Huei Chen
The objectives of this study were to determine the variety and amount of various functional components in Scutellaria barbata D. Don as well as study their anti-inflammatory activity on RAW 264.7 cells. Both ethanol and ethyl acetate extracts were shown to contain the functional components including phenolics, flavonoids, chlorophylls, and carotenoids, with the former mainly composed of phenolics and flavonoids, and the latter of carotenoids and chlorophylls. Both extracts could significantly inhibit (p < 0...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29387570/protective-effect-of-crocin-against-d-galactose-induced-aging-in-mice
#12
Elaheh Mohammadi, Soghra Mehri, Hasan Badie Bostan, Hossein Hosseinzadeh
Objective: Aging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of the active components of saffron showed strong antioxidant effects. In the present study, anti-aging property of crocin was investigated in mice. Materials and Methods: The model of aging was induced using administration of d-galactose (500 mg/kg, s...
January 2018: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29377296/genipin-ameliorates-diet-induced-obesity-via-promoting-lipid-mobilization-and-browning-of-white-adipose-tissue-in-rats
#13
Lili Guan, Dezheng Gong, Sirao Yang, Nana Shen, Sai Zhang, Yuchen Li, Qiong Wu, Bo Yuan, Yiping Sun, Ning Dai, Liang Zhu, Yuan Zou
Genipin is the major active component of Gardeniae fructus and has been shown to ameliorate diabetes and insulin resistance in rat models. In this study, we first investigated the effect of genipin on obesity and the related lipid metabolism mechanisms in diet-induced obese rats. Our results showed that genipin reduced body weight, food intake, and visceral fat mass; ameliorated dyslipidemia, glucose intolerance, insulin intolerance, adipocyte hypertrophy, and hepatic steatosis; and reduced serum tumor necrosis factor-α level in diet-induced obese rats...
April 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29358130/ononitol-monohydrate-enhances-prdm16-ucp-1-expression-mitochondrial-biogenesis-and-insulin-sensitivity-via-stat6-and-ltb-4-r-in-maturing-adipocytes
#14
P Subash-Babu, Ali A Alshatwi
Ononitol monohydrate (OMH), a glycoside was originally isolated from Cassia tora (Linn.). Glycosides regulate lipid metabolism but scientific validation desired. Hence, we aimed to evaluate the effect of OMH on enhancing mitochondrial potential, mitochondrial biogenesis, upregulate the expression of brown adipogenesis specific genes in maturing adipocytes. In addition, we observed the inter-relation between adipocyte and T-lymphocyte; whether, OMH treated adipocyte-condition medium stimulate T-cell chemokine linked with insulin resistance...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29222947/safety-and-efficacy-of-guselkumab-in-japanese-patients-with-moderate-to-severe-plaque-psoriasis-a-randomized-placebo-controlled-ascending-dose-study
#15
O Nemoto, K Hirose, S Shibata, K Li, H Kubo
BACKGROUND: The interleukin (IL)-23/IL-17 pathway is central in the pathogenesis of psoriasis. The favourable efficacy and safety of guselkumab, an IL-23-specific monoclonal antibody, has been demonstrated in global phase III studies of plaque psoriasis. OBJECTIVES: To evaluate the safety, efficacy and pharmacokinetics of single-dose subcutaneous guselkumab in Japanese patients with moderate-to-severe plaque psoriasis. METHODS: Patients with ≥ 10% of total body surface area involvement and a Psoriasis Area and Severity Index (PASI) ≥ 12 were randomized (5 : 1) to receive guselkumab or placebo in four cohorts of this double-blind, placebo-controlled, single ascending-dose, single-centre study...
December 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29178897/microrna-expression-changes-in-association-with-changes-in-interleukin-1%C3%A3-interleukin10-ratios-produced-by-monocytes-in-autism-spectrum-disorders-their-association-with-neuropsychiatric-symptoms-and-comorbid-conditions-observational-study
#16
Harumi Jyonouchi, Lee Geng, Deanna L Streck, James J Dermody, Gokce A Toruner
BACKGROUND: MicroRNAs (miRNAs) play a major role in regulating immune responses at post-transcriptional levels. Previously, we have reported fluctuating interlukine-1ß (IL-1ß)/IL-10 ratios produced by peripheral blood monocytes (PBMo) in some patients with autism spectrum disorders (ASD). This study examined whether changes in miRNA expression by PBMo are associated with changes in IL-1ß/IL-10 ratios and how such changes are associated with ASD clinical features. METHODS: miRNA expression by purified PBMo from ASD subjects (N = 69) and non-ASD controls (N = 27) were determined by high-throughput sequencing...
November 25, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29045892/wait-wait-%C3%A2-ok-now-go-in-inkt-cells-resolve-liver-inflammation
#17
Haiguang Wang, Kristin A Hogquist
Resolution of inflammation is pivotal to restoring tissue homeostasis, yet there is limited understanding of how this process is regulated. In this issue of Immunity, Liew et al. (2017) reveal a critical role for invariant natural killer T (iNKT) cells in switching inflammation to tissue repair in an interlukin-4-dependent process.
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29026700/relationship-between-the-remaining-dentin-thickness-and-coronal-pulp-status-of-decayed-primary-molars
#18
Roula Berbari, Hussein Fayyad-Kazan, Mohamad Ezzedine, Mohammad Fayyad-Kazan, Daniel Bandon, Elia Sfeir
AIMS AND OBJECTIVES: The aim of this study was to assess the correlation between the remaining dentin thickness (RDT) in deep decayed primary molars and the inflammatory status and bacterial composition of the corresponding coronal pulp. We hypothesized that RDT could be used as a reference for clinicians in assigning the indication for pulpotomy. MATERIALS AND METHODS: Pulpotomies were conducted on the cameral pulp of 48 primary molars. Microorganisms, such as Lactobacillus sp...
September 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28962079/corilagin-protects-the-acute-lung-injury-by-ameliorating-the-apoptosis-pathway
#19
Shixun Guo, Yun Fu, Shenming Xiong, Jiudi Lv
This study elucidates the protective effect of corilagin in acute lung injury rat model. Lung injury induced by ischemia/reperfusion (I/R) model was established by isolating the lungs from the rats. Ischemia was produced for the duration of 1h and thereafter reperfusion was done for 90min in isolated lung in presence and absence of corilagin (20 and 40mg/ml). Effect of corilagin was evaluated by estimating the pulmonary vein oxygen partial pressure (PaO2), airway compliance and tidal volume. Moreover the level of oxidative stress parameter, pro inflammatory parameters, phosphorylation of JNK and apoptosis rate was estimated in lung tissues...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28951522/il-10-1082-a-g-rs1800896-polymorphism-confers-susceptibility-to-pulmonary-tuberculosis-in-caucasians-but-not-in-asians-and-africans-a-meta-analysis
#20
Mohammed Y Areeshi, Raju K Mandal, Sajad A Dar, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, Bhartendu N Mishra, Naseem Akhter, Shafiul Haque
BACKGROUND: Earlier studies have shown that interlukin-10 (IL-10) -1082 A>G gene polymorphism is implicated in susceptibility to pulmonary tuberculosis (PTB), but their results are inconsistent and inconclusive. In the present study, a meta-analysis was performed to analyze the potential association between IL-10 -1082 A>G gene polymorphism and PTB susceptibility. METHODS: A quantitative synthesis was done using PubMed (Medline), EMBASE, and Google Scholar web databases search and meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models...
October 31, 2017: Bioscience Reports
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