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https://www.readbyqxmd.com/read/29232040/geographic-disparity-in-kidney-transplantation-under-kas
#1
Sheng Zhou, Allan B Massie, Xun Luo, Jessica M Ruck, Eric K H Chow, Mary G Bowring, Sunjae Bae, Dorry L Segev, Sommer E Gentry
The Kidney Allocation System fundamentally altered kidney allocation, causing a substantial increase in regional and national sharing that we hypothesized might impact geographic disparities. We measured geographic disparity in deceased donor kidney transplant (DDKT) rate under KAS (6/1/2015-12/1/2016), and compared that with pre-KAS (6/1/2013-12/3/2014). We modeled DSA-level DDKT rates with multilevel Poisson regression, adjusting for allocation factors under KAS. Using the model we calculated a novel, improved metric of geographic disparity: the median incidence rate ratio (MIRR) of transplant rate, a measure of DSA-level variation that accounts for patient casemix and is robust to outlier values...
December 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29230502/-acceptance-of-post-mortem-organ-donation-in-germany-representative-cross-sectional-study
#2
E Tackmann, S Dettmer
BACKGROUND: The German post-mortem organ donation rate has dropped by one third since 2010. Furthermore, 958 patients died in 2015 in Germany while waiting for an organ. To decrease organ shortage, an amendment of the transplantation law was established in 2012. An information package including an organ donor card is sent to all German citizens via the postal service. A voluntary national transplantation register was introduced in 2016 to improve transparency in the organ donation process...
December 11, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29228112/xenotransplantation-the-current-status-and-prospects
#3
D K C Cooper, R Gaston, D Eckhoff, J Ladowski, T Yamamoto, L Wang, H Iwase, H Hara, M Tector, A J Tector
Introduction: There is a continuing worldwide shortage of organs from deceased human donors for transplantation into patients with end-stage organ failure. Genetically engineered pigs could resolve this problem, and could also provide tissues and cells for the treatment of conditions such as diabetes, Parkinson's disease and corneal blindness. Sources of data: The current literature has been reviewed. Areas of agreement: The pathobiologic barriers are now largely defined...
December 8, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29222929/hiv-deceased-donor-referrals-a-national-survey-of-organ-procurement-organizations
#4
Ayla Cash, Xun Luo, Eric K H Chow, Mary Grace Bowring, Ashton A Shaffer, Brianna Doby, Corey E Wickliffe, Charles Alexander, Deborah McRann, Aaron A R Tobian, Dorry L Segev, Christine M Durand
BACKGROUND: HIV-infected (HIV+) donor organs can be transplanted into HIV+ recipients under the HIV Organ Policy Equity (HOPE) Act. Quantifying HIV+ donor referrals received by Organ Procurement Organizations (OPOs) is critical for HOPE Act implementation. METHODS: We surveyed the 58 US OPOs regarding HIV+ referral records and newly discovered HIV+ donors. Using data from OPOs that provided exact records and CDC HIV prevalence data, we projected a national estimate of HIV+ referrals...
December 9, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29217864/post-reperfusion-bronchospasm-in-a-deceased-donor-liver-transplant-recipient-an-enigma
#5
Kiran Bharath, Amar Nandhakumar, Harendra Singh, Vivekanandan Shanmugam
No abstract text is available yet for this article.
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29217538/compelling-evidence-of-the-need-for-policy-change-to-decrease-deceased-donor-kidney-discard-in-the-united-states-waste-not-want-less
#6
EDITORIAL
Matthew Kadatz, John S Gill
No abstract text is available yet for this article.
December 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29217537/characteristics-and-performance-of-unilateral-kidney-transplants-from-deceased-donors
#7
Syed Ali Husain, Mariana C Chiles, Samnang Lee, Stephen O Pastan, Rachel E Patzer, Bekir Tanriover, Lloyd E Ratner, Sumit Mohan
BACKGROUND AND OBJECTIVES: The fraction of kidneys procured for transplant that are discarded is rising in the United States. Identifying donors from whom only one kidney was discarded allows us to control for donor traits and better assess reasons for organ discard. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective cohort study using United Network for Organ Sharing Standard Transplant Analysis and Research file data to identify deceased donors from whom two kidneys were procured and at least one was transplanted...
December 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29216531/living-donor-liver-transplantation-for-adult-budd-chiari-syndrome-resection-without-replacement-of-retrohepatic-ivc-a-case-report
#8
Tarek Abdelazeem Sabra, Hideaki Okajima, Tetsuya Tajima, Ken Fukumitsu, Koichiro Hata, Kentaro Yasuchika, Toshihiko Masui, Kojiro Taura, Toshimi Kaido, Shinji Uemoto
INTRODUCTION: Suprahepatic caval resection and replacement of inferior vena cava (IVC) is standard procedure in deceased donor liver transplantation for patients with Budd-Chiari syndrome (BCS). However, replacement of IVC in living donor liver transplantation (LDLT) is difficult. We report a case of BCS successfully treated by LDLT without replacement of IVC. PRESENTATION OF CASE: A 52-years-old female with a primary BCS due to IVC thrombosis. A vena cava (VC) stent placed after angioplasty without improvement of the hepatic, portal venous flow and liver functions, Transjugular intrahepatic portosystemic shunt was considered and the patient had a rapid deterioration and increased ascites...
December 1, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29210108/kidney-transplant-outcomes-from-older-deceased-donors-a-paired-kidney-analysis-by-the-era-edta-registry
#9
Maria Pippias, Kitty J Jager, Fergus Caskey, Anna Casula, Helen Erlandsson, Patrik Finne, James Heaf, Georg Heinze, Andries Hoitsma, Reinhard Kramar, Marko Lempinen, Angela Magaz, Karsten Midtvedt, Lisa L Mumford, Julio Pascual, Karl G Prütz, Søren S Sørensen, Jamie P Traynor, Ziad A Massy, Rommel Ravanan, Vianda S Stel
As the median age of deceased kidney donors rises, updated knowledge of transplant outcomes from older deceased donors in differing donor-recipient age groups is required. Using ERA-EDTA Registry data we determined survival outcomes of kidney allografts donated from the same older deceased donor (55-70 years), and transplanted into one recipient younger and one recipient of similar age to the donor. The recipient pairs were divided into two groups: group 1; younger (median age: 52 years) and older (60 years), and group 2; younger (41 years) and older (60 years)...
December 5, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29210106/preemptive-second-kidney-transplantation-is-associated-with-better-graft-survival-compared-to-non-preemptive-second-transplantation-a-multicenter-french-2000-2014-cohort-study
#10
S Girerd, N Girerd, K Duarte, C Legendre, G Mourad, V Garrigue, E Morelon, F Buron, N Kamar, A Del Bello, M Ladrière, M Kessler, L Frimat
BACKGROUND: The impact of preemptive second kidney transplantation (2KT) on graft and patient survival is poorly established. METHODS: The association between preemptive 2KT (p2KT, N=93) and outcomes was estimated in a multicenter French cohort of 2KT (N=1314) recipients using propensity score methods. RESULTS: During follow-up, there were 274 returns to dialysis and 134 deaths. p2KT was associated with lower death-censored graft loss = 0...
December 5, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29206661/the-need-and-opportunity-for-donation-after-circulatory-death-worldwide
#11
Martí Manyalich, Helen Nelson, Francis L Delmonico
PURPOSE OF REVIEW: The global shortage of organ donors will not be resolved solely by relying on deceased donation following a brain death determination (DBD). Expansion of deceased donation after circulatory death (DCD) will be needed to address the shortfall of organs for transplantation. Approximately 120 000 organ transplants are performed each year; however, the WHO estimates that this number of transplants only resolves 10% of the annual worldwide transplant need. RECENT FINDINGS: The report addresses the opportunity of DCD expansion by evaluating the DCD potential that is not being realized, the utility of DCD enabling DBD to emerge in some clinical situations, by the effectiveness of a donor registry in achieving DCD, and by the current clinical research of heart, lung, and liver transplantation from DCD...
December 4, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29206087/alemtuzumab-induction-is-associated-with-an-equalization-of-outcomes-between-white-and-african-american-kidney-transplant-recipients
#12
Joseph T Brooks, Graham Mitro, Anthony DeLeonibus, Weikai Qu, Michael Rees, Munier Nazzal, Jorge Ortiz
OBJECTIVES: Our aim was to assess outcomes in White and African American kidney transplant recipients after induction with alemtuzumab. MATERIALS AND METHODS: We performed a retrospective study of 464 patients who received deceased-donor kidney transplants and were induced with alem-tuzumab between March 2006 and May 2015. We evaluated ethnic influences on patient and graft survival, delayed graft function, allograft failure, and rejection. RESULTS: There were 337 White (67...
December 5, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29204889/authorization-of-tissues-from-deceased-patients-for-genetic-research
#13
Maureen Wilson-Genderson, K Laura Barker, Heather M Gardiner, Maghboeba Mosavel, Jeffrey Thomas, Laura A Siminoff
Tissues from deceased donors provide important data for genomic research and Organ Procurement Organizations (OPOs) play a significant role. To understand the decisions of families who donated for transplantation and made decisions about donation to the Genotype-Tissue Expression Project (GTEx), we examined donation decisions of family decision makers (FDMs). 413 families were interviewed by telephone. The OPO staff who made the transplant and research requests completed self-administered surveys; a total of 309 matching surveys from 99 OPO staff were obtained...
December 4, 2017: Human Genetics
https://www.readbyqxmd.com/read/29202119/enrichment-of-retroviral-sequences-in-brain-tissue-from-patients-with-severe-demyelinating-diseases
#14
J D Kriesel, P J Bhetariya, B K Chan, T Wilson, K F Fischer
Background: Our group has used deep sequencing to identify viral RNA signatures in human brain specimens. We have previously used this method to detect HSV1, GBV-C, and measles virus sequence in brain tissue from deceased donors. Deep sequencing was performed on brain specimens from a cohort of patients who died with progressive forms of MS, revealing evidence of increased expression of some human endogenous retrovirus (HERV) domains. Objectives: Identify RNA sequences and new antigens involved in the pathogenesis of MS...
August 2017: Journal of Emerging Diseases and Virology
https://www.readbyqxmd.com/read/29198693/impact-of-ethylene-glycol-toxicity-on-donor-organ-viability-a-case-report
#15
N L Mendelson, A Fitzgerald, A Kumar, J A Pineda, J MacDougall, R J Solomon, P C Gibson, M Prikis, C E Marroquin
Using kidneys from deceased donors whose demise was secondary to ethylene glycol (EG) toxicity requires considerable thought and planning. The exact impact that kidneys from these donors could have is unclear. The shortage of viable organs and growing wait list mortality should lead us to consider these allografts as potential life-saving transplants. Because it is crucial for the transplant community to use every available allograft, we need to develop processes that optimize each possible scenario. This article is a discussion of the viability of kidneys from a donor with EG-induced brain death and a proposed algorithm for encouraging the use of renal allografts after EG toxicity...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198692/successful-recombinant-thrombomodulin-treatment-for-thrombotic-microangiopathy-after-liver-transplantation-a-case-report
#16
T Motomura, T Yoshizumi, M Ohira, Y Mano, T Toshima, S Itoh, N Harada, N Harimoto, T Ikegami, Y Soejima, Y Maehara
Transplant-associated thrombotic microangiopathy (TA-TMA) is a rare but severe complication after liver transplantation. In contrast to other thrombotic microangiopathies, treatment for TA-TMA has yet to be clarified. A 52-year-old male patient with liver cirrhosis due to hepatitis C underwent split liver transplantation from a deceased donor. His clinical course was without complication until 4 days after transplantation, when he experienced impaired consciousness, hemolytic anemia with fragmented erythrocytes, and marked thrombocytopenia...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198690/preexisting-cerebral-aspergillosis-successfully-treated-after-liver-transplantation-a-case-report
#17
J S Lee, S-H Kim, J H Kwon, Y C Yoon
BACKGROUND: Invasive aspergillosis (IA) is a rare condition that generally affects immunosuppressed patients. The mortality of IA is known to be >90% in liver transplantation (LT) recipients; the lung is the most commonly affected organ, followed by the brain. There have been reports in the literature of cerebral aspergillosis (CA) in LT recipients. In all previous reports, CA developed after LT. We present the first case (to the best of our knowledge) of preexisting CA diagnosed and successfully treated after LT...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198688/hanging-hepato-atrial-anastomosis-in-deceased-donor-liver-transplantation-for-budd-chiari-syndrome-with-extensive-vena-cava-obliteration-a-case-report
#18
S Y Hong, B-W Kim, H-J Wang, I-G Kim, X-G Hu
INTRODUCTION: Although outcomes of liver transplantation (LT) have improved as the result of progress in surgical procedures, a failure to restore sufficient graft outflow may yield fatal consequences including graft dysfunction and even graft loss to date. In particular, patients with pre-existing obliterated venous drainage, such as those with Budd-Chiari syndrome (BCS), are at high risk of having venous complications followed by conventional LT. In selected cases, the transplant surgeons are compelled to modify the surgical procedures of LT from the conventional procedure...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198682/case-report-treatment-of-renal-artery-aneurysms-by-ex%C3%A2-vivo-renal-artery-aneurysm-repair-and-transplantation
#19
L S Silski, M L Henry, A Rajab, R P Pelletier
BACKGROUND: Renal artery aneurysms are increasingly being detected incidentally during diagnostic imaging using magnetic resonance imaging, computed tomography, or angiography performed for evaluation of other diseases. Our understanding of their natural history and surgical management has evolved significantly during the past two decades. PATIENTS AND METHODS: Three patients with incidentally identified renal artery aneurysms have been referred to our renal transplantation program in the last 3 years...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198667/donation-after-circulatory-arrest-in-pancreas-transplantation-a-report-of-10-cases
#20
J A Fridell, R S Mangus, C M Thomas, C A Kubal, J A Powelson
INTRODUCTION: Transplantation of pancreas allografts procured from donation after circulatory death (DCD) remains uncommon. This study reviews a series of pancreas transplants at a single center to assess the donor and recipient characteristics for DCD pancreas transplant and to compare clinical outcomes. METHODS: DCD procurement was performed with a 5-minute wait time from pronouncement of death to first incision. In 2 patients, tissue plasminogen activator was infused as a thrombolytic during the donor flush...
December 2017: Transplantation Proceedings
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