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https://www.readbyqxmd.com/read/29452450/-cost-comparison-of-licensed-intravitreal-therapies-for-insufficiently-anti-vegf-responding-fovea-involving-diabetic-macular-edema-in-germany
#1
Aljoscha S Neubauer, Christos Haritoglou, Michael W Ulbig
BACKGROUND: In the treatment of center-involving diabetic macular edema, despite initial therapy with an anti-VEGF compound, an insufficient response may occur. Further therapy options include a switch of anti-VEGF products or to corticosteroid implants, such as Fluocinolone acetonide or Dexamethasone. OBJECTIVES: Firstly, to investigate systematically which evidence-based study data are available describing the efficacy of in-label treatments after primary anti-VEGF treatment, secondly, to investigate which costs go along for the healthcare provider...
February 16, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29451077/intravitreal-aflibercept-versus-ranibizumab-for-wet-age-related-macular-degeneration-a-cost-effectiveness-analysis
#2
Luis Hernandez, Tereza Lanitis, Clifford Cele, Hector Toro-Diaz, Andrea Gibson, Andreas Kuznik
BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of vision loss in the United States. The most severe vision loss occurs in patients with neovascular AMD, known as wet AMD (wAMD). The most commonly used antivascular endothelial growth factor (VEGF) therapies approved by the FDA to treat patients with wAMD are ranibizumab, 0.5 mg administered by intravitreal injection once a month (approximately every 28 days), and intravitreal aflibercept injection (IAI), 2 mg every 4 weeks (monthly) for the first 12 weeks (3 months), followed by IAI 2 mg once every 8 weeks (2 months)...
February 16, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29447089/aflibercept-versus-bevacizumab-and-or-ranibizumab-for-recurrent-macular-edema-secondary-to-central-retinal-vein-occlusion
#3
Cem Ozgonul, Vaidehi S Dedania, Cagri G Besirli
PURPOSE: To compare functional and anatomic outcomes of treatment with intravitreal aflibercept versus bevacizumab and/or ranibizumab in patients with recurrent macular edema (ME) secondary to central retinal vein occlusion (CRVO). METHODS: Retrospective, comparative case series of patients with recurrent ME in the setting of CRVO. Patients with recurrent ME received treatment with aflibercept (Group 1, G1) or bevacizumab and/or ranibizumab (Group 2, G2). Primary outcome measures were best-corrected visual acuity (BCVA) and central foveal thickness (CFT)...
February 15, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29445522/early-changes-in-macular-optical-coherence-tomography-parameters-after-ranibizumab-intravitreal-injection-in-patients-with-exsudative-age-related-macular-degeneration
#4
Nicole Antunes de Almeida, Osias Francisco de Souza
Background: Evaluation of the impact of different macular optical coherence parameters on visual acuity as early as 1 day after injection of ranibizumab in patients with subfoveal exsudative age-related macular degeneration. Methods: This was an interventional, non randomized, open label prospective study, where we evaluated 20 eyes of 20 patients affected by exudative age-related macular degeneration. These patients were treated with injections of ranibizumab between February 2013 and January 2015...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29443804/progression-of-retinal-ischemia-in-a-case-of-macular-telangiectasia-type-1-after-ranibizumab-injection-optical-coherence-tomography-angiography-findings
#5
Massimo Lorusso, Roberta Zito, Eleni Nikolopoulou, Luisa Micelli Ferrari, Maria Vittoria Cicinelli, Giuseppe Querques, Tommaso Micelli Ferrari
PURPOSE: To describe a case of a 68-year-old man with macular telangiectasia (MacTel) Type 1 in the right eye, showing an increase in capillary ischemia after intravitreal ranibizumab. METHODS: The patient underwent complete ophthalmologic evaluation, including best-corrected visual acuity, intraocular pressure, anterior segment and fundus examination, optical coherence tomography (OCT), and OCT angiography at baseline and on each visit. Fluorescein angiography was performed at baseline...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29437495/incidence-of-endophthalmitis-after-intravitreal-injections-risk-factors-microbiology-profile-and-clinical-outcomes
#6
Chitaranjan Mishra, Prajna Lalitha, Gunasekaran Rameshkumar, Rupesh Agrawal, Praveen Kumar Balne, Mani Iswarya, Naresh Babu Kannan, Kim Ramasamy
PURPOSE: To report the incidence and characteristics of endophthalmitis after intravitreal injections (IVI) of antivascular endothelial growth factor agents and triamcinolone acetonide. METHODS: Patients' medical records were retrospectively reviewed from January 2009 to June 2016, and the incidence, risk factors, clinical and microbiological characteristics of post-IVI endophthalmitis were evaluated. RESULTS: The total number of intravitreal injections given, which included ranibizumab, bevacizumab, and triamcinolone acetonide, was 20,566, of which 27 cases developed endophthalmitis, giving an overall incidence of 0...
February 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29434739/intravitreal-ranibizumab-injection-combined-with-photodynamic-therapy-for-polypoidal-choroidal-vasculopathy
#7
Jia Li, Jianhua Sun, Bing Li, Zheli Liu
The aim of the present study was to evaluate the efficacy of combination treatment with intravitreal ranibizumab (IVR) injection and photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV). A total of 64 patients with PCV were included in the present study, which were divided into the IVR monotherapy group (Group A) and combination treatment groups (Groups B-D) with different treatment intervals. All subjects were followed-up at 1, 3, 6 and 12 months following treatment, and subjected to the detection of best-corrected visual acuity (BCVA) and central foveal thickness (CFT)...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29426292/pre-treatment-clinical-features-in-central-retinal-vein-occlusion-that-predict-visual-outcome-following-intravitreal-ranibizumab
#8
Kerr Brogan, Monica Precup, Amanda Rodger, David Young, David Francis Gilmour
BACKGROUND: Predicting how patients with central retinal vein occlusion (CRVO) will respond to intravitreal anti-VEGF is challenging. The purpose of this study was to identify pre-treatment clinical features in CRVO that predict visual acuity (VA) following intravitreal ranibizumab. METHODS: Medical records, fundus images and optical coherence tomography (OCT) scans of treatment naïve patients with CRVO receiving PRN intravitreal ranibizumab were retrospectively reviewed...
February 9, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29425544/ranibizumab-and-digital-ischemia
#9
R Attal, I Lazareth, G Angelopoulos, P Priollet
Case report of a patient with age-related macular degeneration whose digital ischemia can most plausibly be attributed to ranibizumab. PURPOSE: To report ranibizumab as the probable cause of digital ischemia in a patient treated for age-related macular degeneration. METHODS: Single-patient case report. RESULTS: An 83-year-old woman with an unremarkable medical history suffered acute ischemia in her left hand with necrosis of the distal phalange of the fifth finger after six intravitreal injections of ranibizumab...
February 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29422766/inhibition-of-yap-ameliorates-choroidal-neovascularization-via-inhibiting-endothelial-cell-proliferation
#10
Zhenzhen Yan, Haihong Shi, Rongrong Zhu, Lele Li, Bai Qin, Lihua Kang, Hui Chen, Huaijin Guan
Purpose: Age-related macular degeneration (AMD) is the leading cause of central visual loss among patients over the age of 55 years worldwide. Neovascular-type AMD (nAMD) accounts for approximately 10% of patients with AMD and is characterized by choroidal neovascularization (CNV). The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29405046/anti-vegf-agents-and-the-risk-of-arteriothrombotic-events
#11
Marco A Zarbin
Blockade of vascular endothelial growth factor (VEGF) signaling, whether via sequestration of free VEGF or via inhibition of the tyrosine kinases activated by VEGF, is associated with decreased nitric oxide (NO) and prostaglandin-I 2 (PG-I 2) production along with vascular endothelial cell death. Systemic administration of drugs that block VEGF signaling (eg, for cancer treatment) is associated with systemic complications such as hypertension and thrombosis. Evidence regarding the risk of systemic serious adverse events after intravitreal injection of anti-VEGF agents in patients with diabetic macular edema or neovascular age-related macular degeneration is inconsistent, in part because of study design limitations (eg, bias of ascertainment through strict enrollment criteria and/or inadequate power to identify the risk of low frequency events)...
February 1, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29404860/ranibizumab-versus-aflibercept-for-the-treatment-of-vascularized-pigment-epithelium-detachment-due-to-age-related-macular-degeneration
#12
Alexandros Rouvas, Irini Chatziralli, Angeliki Androu, Panagiota Mpougatsou, Dimitrios Alonistiotis, Maria Douvali, Stamatina A Kabanarou, Panagiotis Theodossiadis
PURPOSE: To compare the efficacy and safety of two intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents, ranibizumab and aflibercept, for the treatment of vascularized pigment epithelium detachment (vPED) due to age-related macular degeneration (AMD) in a follow-up time of 12 months. METHODS: Participants in this study were 71 patients (71 eyes) with vPED due to AMD, who were treated with intravitreal 0.5 mg ranibizumab (n = 38) or 2.0 mg aflibercept (n = 33) and had at least 12-month follow-up...
February 5, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29403260/evaluation-of-contrast-sensitivity-and-other-visual-function-outcomes-in-diabetic-macular-edema-patients-following-treatment-switch-to-aflibercept-from-ranibizumab
#13
Donald R Nixon, Nicholas Ap Flinn
Purpose: This study aims to investigate changes in contrast sensitivity (CS), visual acuity (VA), central retinal thickness (CRT), and vision-related quality of life in subjects with recalcitrant diabetic macular edema switched from long-term ranibizumab treatment to aflibercept. Patients and methods: In this prospective, investigator-masked, single-center study, 40 patients with persistent fluid, despite previous ranibizumab treatment, were switched to aflibercept with 5 consecutive monthly doses...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29399095/predicting-the-visual-acuity-for-retinal-vein-occlusion-after-ranibizumab-therapy-with-an-original-ranking-for-macular-microstructure
#14
Haiyang Liu, Suyan Li, Zhengpei Zhang, Jie Shen
The study investigated predictive factors for best-corrected visual acuity (BCVA) after ranibizumab treatment in patients with macular edema (ME) associated with retinal vein occlusion (RVO) with an original ranking for the impairment of macular microstructure. In this retrospective study, 31 eyes of 31 patients with RVO received 3 monthly consecutive ranibizumab injections and another 3 months of follow-up. An original method was applied to rank the impairment of the external limiting membrane (ELM) and the ellipsoid zone (previously called the photoreceptor inner and outer segment junction, IS/OS) integrity on the baseline optical coherence tomography (OCT) images...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29398697/clinical-pharmacology-of-intravitreal-anti-vegf-drugs
#15
REVIEW
Stefano Fogli, Marzia Del Re, Eleonora Rofi, Chiara Posarelli, Michele Figus, Romano Danesi
Clinical efficacy of intravitreal anti-VEGF drugs has been widely demonstrated in several angiogenesis-driven eye diseases including diabetic macular edema and the neovascular form of age-related macular degeneration. Pegaptanib, ranibizumab, and aflibercept have been approved for use in the eye, whereas bevacizumab is widely used by ophthalmologists to treat patients "off-label". These drugs are active in the nanomolar to picomolar range; however, caution is required when establishing the rank order of affinity and potency due to in vitro inter-experimental variation...
February 5, 2018: Eye
https://www.readbyqxmd.com/read/29395119/ranibizumab-plus-panretinal-photocoagulation-versus-panretinal-photocoagulation-alone-for-high-risk-proliferative-diabetic-retinopathy-proteus-study
#16
João Figueira, Emily Fletcher, Pascale Massin, Rufino Silva, Francesco Bandello, Edoardo Midena, Monica Varano, Sobha Sivaprasad, Haralabos Eleftheriadis, Geeta Menon, Miguel Amaro, Sarah Ayello Scheer, Catherine Creuzot-Garcher, João Nascimento, Dalila Alves, Sandrina Nunes, Conceição Lobo, José Cunha-Vaz
PURPOSE: Comparison of the efficacy of ranibizumab (RBZ) 0.5 mg intravitreal injections plus panretinal photocoagulation (PRP) versus PRP alone in the regression of the neovascularization (NV) area in subjects with high-risk proliferative diabetic retinopathy (HR-PDR) over a 12-month period. DESIGN: Prospective, randomized, multicenter, open-label, phase II/III study. PARTICIPANTS: Eighty-seven participants (aged ≥18 years) with type 1/2 diabetes and HR-PDR (mean age, 55...
January 27, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29393246/genetic-risk-factors-are-not-associated-with-wet-age-related-macular-degeneration-treatment-response-to-ranibizumab
#17
Varun Chaudhary, Michael Brent, Wai-Ching Lam, Robert Devenyi, Joshua Teichman, Michael Ying-Kit Mak, Harneel Kaur, Joshua Barbosa, Ronald Carter, Forough Farrokhyar
No abstract text is available yet for this article.
January 26, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29392288/persistent-macular-thickening-following-intravitreous-aflibercept-bevacizumab-or-ranibizumab-for-central-involved-diabetic-macular-edema-with-vision-impairment-a-secondary-analysis-of-a-randomized-clinical-trial
#18
Neil M Bressler, Wesley T Beaulieu, Adam R Glassman, Kevin J Blinder, Susan B Bressler, Lee M Jampol, Michele Melia, John A Wells
Importance: Prevalence of persistent central-involved diabetic macular edema (DME) through 24 weeks of anti-vascular endothelial growth factor therapy and its longer-term outcomes may be relevant to treatment. Objective: To assess outcomes of DME persisting at least 24 weeks after randomization to treatment with 2.0-mg aflibercept, 1.25-mg bevacizumab, or 0.3-mg ranibizumab. Design, Setting, and Participants: Post hoc analyses of a clinical trial, DRCR...
February 1, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29390361/comparison-of-the-efficacy-of-intravitreal-ranibizumab-for-choroidal-neovascularization-due-to-pathological-myopia-with-and-without-a-dome-shaped-macula
#19
Bincui Cai, Jin Yang, Shuang Li, Linni Wang, Lu Chen, Xiaorong Li, Zhiqing Li
Ranibizumab injection in the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM) with and without a dome-shaped macula (DSM).Prospective observational study.A total of 24 patients (24 eyes) with angiographic evidence of CNV secondary to PM were divided into 2 groups: eyes with a DSM and eyes without DSM. All patients received a baseline intravitreal ranibizumab injection. Additional injections were considered at each follow-up visit. Best-corrected visual acuity (BCVA) and optical coherence tomography were tested monthly through 12 months of follow-up...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29389239/effects-of-bevacizumab-ranibizumab-and-aflibercept-on-microrna-expression-in-a-retinal-pigment-epithelium-cell-culture-model-of-oxidative-stress
#20
Erdem Dinç, Lokman Ayaz, Akif Hakan Kurt
PURPOSE: This study aimed to evaluate the effects of bevacizumab, ranibizumab, and aflibercept on the microRNA (miRNA) expression in human retinal pigment epithelium cell (ARPE-19) culture model of oxidative stress. METHODS: Control cells were cultured in the hydrogen peroxide (H2O2)-free medium. In H2O2 group ARPE-19 cells were exposed to 600 μM H2O2 alone for 18 h. In study groups, cells were preincubated with bevacizumab, ranibizumab, and aflibercept (1...
February 1, 2018: Journal of Ocular Pharmacology and Therapeutics
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