Raquel Herrero-Labrador, Joaquín Fernández-Irigoyen, Rebeca Vecino, Candela González-Arias, Karina Ausín, Inmaculada Crespo, Francisco J Fernández Acosta, Vanesa Nieto-Estévez, M José Román, Gertrudis Perea, Ignacio Torres-Alemán, Enrique Santamaría, Carlos Vicario
Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of Igf-I in the nervous system ( Igf-I Δ/Δ ), and demonstrated that long-term potentiation was impaired in hippocampal slices. Moreover, Igf-I Δ/Δ mice showed spatial memory deficits in the Morris water maze, and the significant sex-dependent differences displayed by Igf-I Ctrl/Ctrl mice disappeared in Igf-I Δ/Δ mice in the open field and rota-rod tests...
October 2023: Life Science Alliance