keyword
https://read.qxmd.com/read/38145031/characteristics-of-the-patients-aged-less-than-40-years-operated-for-a-renal-mass
#21
JOURNAL ARTICLE
Abdullah Ilktac, Bayram Dogan, Cevper Ersoz, Ganime Coban, Senad Kalkan
The incidence of renal cell cancer (RCC) is low in individuals aged less than 40 years; however several studies have shown this increasing trend over the years. Hereditary syndromes are associated with RCC and are more frequently observed in early-onset cases. In this study, we investigated the characteristics of the patients, aged less than 40 years, who were operated for a renal mass with the suspicion of RCC. We analyzed patients aged <40 years who underwent partial or radical nephrectomy between January 2012 and December 2022...
2023: Journal of Kidney Cancer and VHL
https://read.qxmd.com/read/38142511/design-synthesis-and-biological-evaluation-of-hdac6-inhibitors-targeting-l1-loop-and-serine-531-residue
#22
JOURNAL ARTICLE
Sonam Jha, Ji Hyun Kim, Mikyung Kim, Ai-Han Nguyen, Khan Hashim Ali, Sunil K Gupta, Sun You Park, Eunyoung Ha, Young Ho Seo
Histone deacetylases (HDACs) are a group of enzymes that remove acetyl groups from histones, leading to the silencing of genes. Targeting specific isoforms of HDACs has emerged as a promising approach for cancer therapy, as it can overcome drawbacks associated with pan-HDAC inhibitors. HDAC6 is a unique HDAC isoform that deacetylates non-histone proteins and is primarily located in the cytoplasm. It also has two catalytic domains and a zinc-finger ubiquitin binding domain (Zf-UBD) unlike other HDACs. HDAC6 plays a critical role in various cellular processes, including cell motility, protein degradation, cell proliferation, and transcription...
December 20, 2023: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38114270/spindle-cell-rhabdomyosarcomas-with-tfcp2-rearrangements-and-novel-ewsr1-zbtb41-and-plod2-rbm6-gene-fusions-a-study-of-five-cases-and-review-of-the%C3%A2-literature
#23
JOURNAL ARTICLE
Martina Bradová, Elaheh Mosaieby, Michael Michal, Tomáš Vaněček, Stanislav Kormunda Ing, Petr Grossmann, Olena Koshyk, Zdeněk Kinkor, Šimon Laciok, Antónia Nemcová, Ľubomír Straka, Mihaela Farkas, Michal Michal, Marián Švajdler
AIMS: Spindle-cell/sclerosing rhabdomyosarcomas (SS-RMS) are clinically and genetically heterogeneous. They include three well-defined molecular subtypes, of which those with EWSR1/FUS::TFCP2 rearrangements were described only recently. This study aimed to evaluate five new cases of SS-RMS and to perform a clinicopathological and statistical analysis of all TFCP2-rearranged SS-RMS described in the English literature to more comprehensively characterize this rare tumour type. METHODS AND RESULTS: Cases were retrospectively selected and studied by immunohistochemistry, fluorescence in situ hybridization with EWSR1/FUS and TFCP2 break-apart probes, next-generation sequencing (Archer FusionPlex Sarcoma kit and TruSight RNA Pan-Cancer Panel)...
December 19, 2023: Histopathology
https://read.qxmd.com/read/38090523/real-world-first-line-afatinib-for-advanced-egfr-mutation-positive-non-small-cell-lung-cancer-in-korea-updated-survival-data
#24
JOURNAL ARTICLE
Juwhan Choi, Chang Min Choi, Yoon Soo Chang, Kye Young Lee, Seung Joon Kim, Sei Hoon Yang, Jeong Seon Ryu, Jeong Eun Lee, Shin Yup Lee, Ji Young Park, Young-Chul Kim, In-Jae Oh, Chi Young Jung, Sang Hoon Lee, Seong Hoon Yoon, Sung Yong Lee, Tae Won Jang
BACKGROUND: Data from clinical trials and real-world studies show that afatinib is effective in treating non-small cell lung cancer (NSCLC) harboring activating mutations in the epidermal growth factor receptor ( EGFR ) gene. A previous analysis of patients enrolled in the Korean Academy of Tuberculosis and Respiratory Disease (KATRD) EGFR cohort showed that first-line afatinib was well tolerated and effectiveness results were encouraging. At the time of the previous analysis, survival data were not mature...
November 30, 2023: Translational Lung Cancer Research
https://read.qxmd.com/read/38067382/genetic-alterations-and-risk-factors-for-recurrence-in-patients-with-non-small-cell-lung-cancer-who-underwent-complete-surgical-resection
#25
JOURNAL ARTICLE
Hwa Kyung Park, Yoo Duk Choi, Ju-Sik Yun, Sang-Yun Song, Kook-Joo Na, Joon Young Yoon, Chang-Seok Yoon, Hyung-Joo Oh, Young-Chul Kim, In-Jae Oh
A definitive surgical resection is the preferred treatment for early-stage non-small cell lung cancer (NSCLC). Research on genetic alterations, including epidermal growth factor receptor (EGFR) mutations, in early-stage NSCLC remains insufficient. We investigated the prevalence of genetic alterations in early-stage NSCLC and the association between EGFR mutations and recurrence after a complete resection. Between January 2019 and December 2021, 659 patients with NSCLC who underwent curative surgical resections at a single regional cancer center in Korea were recruited...
November 30, 2023: Cancers
https://read.qxmd.com/read/38052344/identification-of-common-factors-among-fibrosarcoma-rhabdomyosarcoma-and-osteosarcoma-by-network-analysis
#26
JOURNAL ARTICLE
Mehran Radak, Nakisa Ghamari, Hossein Fallahi
Sarcoma cancers are uncommon malignant tumors, and there are many subgroups, including fibrosarcoma (FS), which mainly affects middle-aged and older adults in deep soft tissues. Rhabdomyosarcoma (RMS), on the other hand, is the most common soft-tissue sarcoma in children and is located in the head and neck area. Osteosarcomas (OS) is the predominant form of primary bone cancer among young adults, primarily resulting from sporadically random mutations. This frequently results in the dissemination of cancer cells to the lungs, commonly known as metastasis...
December 3, 2023: Bio Systems
https://read.qxmd.com/read/38033642/anticancer-effects-of-alpelisib-on-pik3ca-mutated-canine-mammary-tumor-cell-lines
#27
JOURNAL ARTICLE
Jiah Yeom, Yoonju Cho, Seoungyob Ahn, Soyoung Jeung
Canine mammary tumors (CMTs) are commonly observed in old and unspayed female dogs. Recently, dogs have been increasingly spaying at a young age to prevent mammary tumors. These CMTs require extensive local excision and exhibit a high probability of metastasis to the regional lymph nodes and lungs during malignancy. However, the molecular and biological mechanisms underlying CMT development have not been fully elucidated, and research in this area is limited. Therefore, in this study, we established new CMT cell lines by isolating cells from tumor tissues and investigated phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), a target for human breast cancer...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/38023218/two-case-reports-eml4-alk-rearrangement-large-cell-neuroendocrine-carcinoma-and-literature-review
#28
Qin Chen, Jingjing Zhang, Xuan Wang, Wenkang Zong, Leina Sun, Jianwen Qin, Yan Yin
Anaplastic lymphoma kinase gene (ALK) rearrangement is present in only approximately 5% of non-small cell lung cancers (NSCLCs) and is scarce in LCNEC patients. The conventional first-line treatment options are chemotherapy combined with immunotherapy or chemotherapy followed by palliative radiotherapy. In this report, we present two cases of metastatic LCNEC with EML4-ALK fusion that were treated with ALK-TKI inhibitors and demonstrated a rapid therapeutic response. Both patients were nonsmoking women who declined cytotoxic chemotherapy, underwent Next-Generation Sequencing (NGS), and confirmed EML4-ALK fusion...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38012621/noggin-contributes-to-brain-metastatic-colonization-of-lung-cancer-cells
#29
JOURNAL ARTICLE
Jung Eun Lee, Jihye Park, Eun Ju Kim, Yoon Ho Ko, Soon Auck Hong, Seung Ho Yang, Young-Ho Ahn
BACKGROUND: Brain metastasis is a common complication among patients with lung cancer, yet the underlying mechanisms remain unclear. In this study, we aimed to investigate the pathogenesis of brain metastasis in lung cancer. METHODS: We established highly colonizing metastatic lung cancer cells, A549-M2, through multiple implantations of A549 human lung cancer cells in the carotid artery of athymic nude mice. RESULTS: Compared to parental cells (M0), M2 cells demonstrated slower growth in culture plates and soft agar, as well as lower motility and higher adhesion, key characteristics of mesenchymal-epithelial transition (MET)...
November 28, 2023: Cancer Cell International
https://read.qxmd.com/read/38006284/investigating-rutin-as-a-potential-transforming-growth-factor-%C3%AE-type-i-receptor-antagonist-for-the-inhibition-of-bleomycin-induced-lung-fibrosis
#30
JOURNAL ARTICLE
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Kyoung Tae Lee, Yung Hyun Choi, Chang-Hee Kang, Mi-Hwa Lee, Sang-Hun Kim, Gi-Young Kim
Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition characterized by the abnormal regulation of extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT). In this study, we investigated the potential of rutin, a natural flavonoid, in attenuating transforming growth factor-β (TGF-β)-induced ECM regulation and EMT through the inhibition of the TGF-β type I receptor (TβRI)-mediated suppressor of mothers against decapentaplegic (SMAD) signaling pathway. We found that non-toxic concentrations of rutin attenuated TGF-β-induced ECM-related genes, including fibronectin, elastin, collagen 1 type 1, and TGF-β, as well as myoblast differentiation from MRC-5 lung fibroblast cells accompanied by the downregulation of α-smooth muscle actin...
November 25, 2023: BioFactors
https://read.qxmd.com/read/37880322/comparative-analysis-of-batch-correction-methods-for-fdg-pet-ct-using-metabolic-radiogenomic-data-of-lung-cancer-patients
#31
JOURNAL ARTICLE
Hyunjong Lee, Sujin Seo, Sungho Won, Woong-Yang Park, Joon Young Choi, Kyung-Han Lee, Se-Hoon Lee, Seung Hwan Moon
In radiomics research, the issue of different instruments being used is significant. In this study, we compared three correction methods to reduce the batch effects in radiogenomic data from fluorodeoxyglucose (FDG) PET/CT images of lung cancer patients. Texture features of the FDG PET/CT images and genomic data were retrospectively obtained. The features were corrected with different methods: phantom correction, ComBat method, and Limma method. Batch effects were estimated using three analytic tools: principal component analysis (PCA), the k-nearest neighbor batch effect test (kBET), and the silhouette score...
October 25, 2023: Scientific Reports
https://read.qxmd.com/read/37862920/comparison-of-immunohistochemistry-and-next-generation-sequencing-results-in-oncogenic-pten-missense-mutations
#32
JOURNAL ARTICLE
Moonsik Kim, Jinhee Kim, An Na Seo, Ji Yun Jeong, Nora Jee-Young Park, Gun Oh Chong, Dae Gy Hong, Ji Young Park
BACKGROUND: Phosphatase and tensin homolog (PTEN) is one of the most frequently mutated tumor suppressor genes in malignant tumors. Oncogenic PTEN mutations have diagnostic, prognostic, and therapeutic implications. Similar to TP53 mutations, oncogenic PTEN mutations can result from nonsynonymous missense mutations. However, there has been no detailed study on the immunostaining pattern of oncogenic PTEN missense mutations. METHODS: We retrospectively selected 18 cancers (13 endometrial cancers, 2 brain tumors, 1 ovarian cancer, 1 lung cancer, and 1 cancer of unknown origin) harboring oncogenic PTEN missense mutations, which were confirmed by targeted next-generation sequencing...
October 10, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/37848457/cancer-associated-fibroblasts-in-early-stage-lung-adenocarcinoma-correlate-with-tumor-aggressiveness
#33
JOURNAL ARTICLE
Georgii Vasiukov, Yong Zou, Maria-Fernanda Senosain, Jamshedur S M Rahman, Sanja Antic, Katherine M Young, Eric L Grogan, Michael N Kammer, Fabien Maldonado, Cynthia A Reinhart-King, Pierre P Massion
Lung adenocarcinoma (LUAD) is the predominant type of lung cancer in the U.S. and exhibits a broad variety of behaviors ranging from indolent to aggressive. Identification of the biological determinants of LUAD behavior at early stages can improve existing diagnostic and treatment strategies. Extracellular matrix (ECM) remodeling and cancer-associated fibroblasts play a crucial role in the regulation of cancer aggressiveness and there is a growing need to investigate their role in the determination of LUAD behavior at early stages...
October 17, 2023: Scientific Reports
https://read.qxmd.com/read/37843249/biomarker-driven-phase-2-umbrella-trial-clinical-efficacy-of-olaparib-monotherapy-and-combination-with-ceralasertib-azd6738-in-small-cell-lung-cancer
#34
JOURNAL ARTICLE
Sehhoon Park, Yu Jung Kim, Young Joo Min, Peter G S Mortimer, Hee-Jung Kim, Simon A Smith, Emma Dean, Hyun Ae Jung, Jong-Mu Sun, Woong-Yang Park, Jin Seok Ahn, Myung-Ju Ahn, Se-Hoon Lee, Keunchil Park
BACKGROUND: Based on a high incidence of genomic alteration in the cell cycle and DNA damage and response (DDR)-related pathways in small cell lung cancer (SCLC), the clinical efficacy of the DDR-targeting agent olaparib (PARP inhibitor) as monotherapy and in combination with ceralasertib (ATR inhibitor) in relapsed or refractory SCLC was evaluated. METHODS: As part of a phase 2 biomarker driven umbrella study, patients with SCLC and predefined DDR gene alterations who failed to benefit from prior platinum-based regimens were allocated to the olaparib monotherapy arm and nonbiomarker-selected patients were allocated to the olaparib and ceralasertib combination arm...
February 15, 2024: Cancer
https://read.qxmd.com/read/37821974/accelerated-epigenetic-age-inflammation-and-gene-expression-in-lung-comparisons-of-smokers-and-vapers-with-non-smokers
#35
JOURNAL ARTICLE
Min-Ae Song, Kellie M Mori, Joseph P McElroy, Jo L Freudenheim, Daniel Y Weng, Sarah A Reisinger, Theodore M Brasky, Mark D Wewers, Peter G Shields
BACKGROUND: Cigarette smoking and aging are the main risk factors for pulmonary diseases, including cancer. Epigenetic aging may explain the relationship between smoking, electronic cigarette vaping, and pulmonary health. No study has examined smoking and vaping-related epigenetic aging in relation to lung biomarkers. METHODS: Lung epigenetic aging measured by DNA methylation (mAge) and its acceleration (mAA) was assessed in young (age 21-30) electronic cigarette vapers (EC, n = 14, including 3 never-smoking EC), smokers (SM, n = 16), and non-EC/non-SM (NS, n = 39)...
October 11, 2023: Clinical Epigenetics
https://read.qxmd.com/read/37808664/context-aware-single-cell-multiome-approach-identified-cell-type-specific-lung-cancer-susceptibility-genes
#36
Erping Long, Jinhu Yin, Ju Hye Shin, Yuyan Li, Alexander Kane, Harsh Patel, Thong Luong, Jun Xia, Younghun Han, Jinyoung Byun, Tongwu Zhang, Wei Zhao, Maria Teresa Landi, Nathaniel Rothman, Qing Lan, Yoon Soo Chang, Fulong Yu, Christopher Amos, Jianxin Shi, Jin Gu Lee, Eun Young Kim, Jiyeon Choi
Genome-wide association studies (GWAS) identified over fifty loci associated with lung cancer risk. However, the genetic mechanisms and target genes underlying these loci are largely unknown, as most risk-associated-variants might regulate gene expression in a context-specific manner. Here, we generated a barcode-shared transcriptome and chromatin accessibility map of 117,911 human lung cells from age/sex-matched ever- and never-smokers to profile context-specific gene regulation. Accessible chromatin peak detection identified cell-type-specific candidate cis -regulatory elements (cCREs) from each lung cell type...
September 26, 2023: bioRxiv
https://read.qxmd.com/read/37784272/genetically-engineered-mouse-models-of-cic-dux4-sarcoma-reveal-an-unexpected-sensitivity-to-histone-deacetylase-hdac-inhibition
#37
JOURNAL ARTICLE
P Hendrickson, K M Oristian, L Lou, Y Ma, D M Cardona, D G Kirsch
PURPOSE/OBJECTIVE(S): Undifferentiated small round cell sarcomas constitute a highly aggressive subtype of soft tissue sarcoma that affects adolescents and young adults. Frequently, these cancers are caused by a gene fusion between the DNA binding domain of capicua (CIC), a canonical tumor suppressor that normally acts as a transcriptional repressor, with the transcriptional activation domain of double homeobox 4 (DUX4). Given the rare nature of CIC-DUX4 sarcoma (CDS), obtaining patient tissues to study the mechanisms of disease is very challenging...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37761019/an-analysis-of-jade2-in-non-small-cell-lung-cancer-nsclc
#38
JOURNAL ARTICLE
Ciara Murphy, Glòria Gornés Pons, Anna Keogh, Lisa Ryan, Lorraine McCarra, Chris Maria Jose, Shagun Kesar, Siobhan Nicholson, Gerard J Fitzmaurice, Ronan Ryan, Vincent Young, Sinead Cuffe, Stephen P Finn, Steven G Gray
The JADE family comprises three members encoded by individual genes and roles for these proteins have been identified in chromatin remodeling, cell cycle progression, cell regeneration and the DNA damage response. JADE family members, and in particular JADE2 have not been studied in any great detail in cancer. Using a series of standard biological and bioinformatics approaches we investigated JADE2 expression in surgically resected non-small cell lung cancer (NSCLC) for both mRNA and protein to examine for correlations between JADE2 expression and overall survival...
September 19, 2023: Biomedicines
https://read.qxmd.com/read/37760631/polo-like-kinase-4-a-multifaceted-marker-linking-tumor-aggressiveness-and-unfavorable-prognosis-and-insights-into-therapeutic-strategies
#39
JOURNAL ARTICLE
Youngtaek Kim, Joon Yeon Hwang, Dong Kwon Kim, Kwangmin Na, Seul Lee, Sujeong Baek, Seong-San Kang, Seung Min Yang, Mi Hyun Kim, Heekyung Han, Chai Young Lee, Yu Jin Han, Min Hee Hong, Jii Bum Lee, Sun Min Lim, Byoung Chul Cho, Youngjoon Park, Kyoung-Ho Pyo
(1) Background: This study investigated whether polo-like kinase 4 (PLK4) is a suitable therapeutic target or biomarker for lung adenocarcinoma (LUAD). (2) Methods: We acquired LUAD data from The Cancer Genome Atlas (TCGA) database through the UCSC Xena data portal. Gene expression, clinical, survival, and mutation data from multiple samples were analyzed. Gene enrichment analysis, unsupervised clustering of PLK4 -related pathways, and differential gene expression analyses were performed. Additionally, correlations, t -tests, survival analyses, and statistical analyses were performed...
September 21, 2023: Cancers
https://read.qxmd.com/read/37752597/towards-a-better-preclinical-cancer-model-human-immune-aging-in-humanized-mice
#40
JOURNAL ARTICLE
Joel H L Tan, You Yi Hwang, Hui Xian Chin, Min Liu, Sue Yee Tan, Qingfeng Chen
BACKGROUND: Preclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models has vastly improved with mice bearing a human immune system, especially in the context of immunotherapy. Nonetheless, cancer is an age-related disease, and studies often overlook the effects of aging. Here we have established a humanized mouse model of human immune aging to investigate the role of this phenomenon on liver tumor dynamics. METHODS: Multiple organs and tissues (blood, thymus, lung, liver, spleen and bone marrow) were harvested from NOD-scid IL2rγ-/- (NIKO) mice reconstituted with human immune cells, over a period of 60 weeks post-birth, for immune profiling...
September 27, 2023: Immunity & Ageing: I & A
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