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https://www.readbyqxmd.com/read/29575851/molecular-screening-of-small-biopsy-samples-using-next-generation-sequencing-in-korean-patients-with-advanced-non-small-cell-lung-cancer-korean-lung-cancer-consortium-klcc-13-01
#1
Bo Mi Ku, Mi Hwa Heo, Joo-Hang Kim, Byoung Chul Cho, Eun Kyung Cho, Young Joo Min, Ki Hyeong Lee, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Tae Jung Kim, Ho Yun Lee, Hojoong Kim, Kyung-Jong Lee, Myung-Ju Ahn
Background: Non-small cell lung cancer (NSCLC) is a common type of cancer with typically poor prognosis. As individual cancers exhibit unique mutation patterns, identifying and characterizing gene mutations in NSCLC might help predict patient outcomes and guide treatment. The aim of this study was to evaluate the clinical adequacy of molecular testing using next-generation sequencing (NGS) for small biopsy samples and characterize the mutational landscape of Korean patients with advanced NSCLC...
March 26, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29561562/fluorometric-detection-of-egfr-exon-19-deletion-mutation-in-lung-cancer-cells-using-graphene-oxide
#2
Dong-Min Kim, Dong Ho Kim, Woong Jung, Kye Young Lee, Dong-Eun Kim
Mutations in epidermal growth factor receptor (EGFR) are known as biomarkers that cause non-small cell lung cancer. Particularly, approximately 45% of non-small cell lung cancer patients possess a deletion in exon 19 of the EGFR gene. A less invasive method for detecting the EGFR mutation is required; thus, we developed a simple polymerase chain reaction (PCR)-based method for detecting EGFR exon 19 deletion by using a quencher-free fluorescent probe DNA and graphene oxide (GO). In the presence of the exon 19 deletion mutation, the fluorophore-labeled DNA probe was designed to be fully complementary to the mutant sequences...
March 21, 2018: Analyst
https://www.readbyqxmd.com/read/29559559/anaplastic-lymphoma-kinase-mutation-alk-f1174c-in-small-cell-carcinoma-of-the-prostate-and-molecular-response-to-alectinib
#3
Benedito A Carneiro, Sahithi Pamarthy, Ami N Shah, Vinay Sagar, Kenji Unno, HuiYing Han, Ximing J Yang, Rubens B Costa, Rebecca J Nagy, Richard B Lanman, Timothy M Kuzel, Jeffrey S Ross, Laurie Gay, Julia A Elvin, Siraj M Ali, Massimo Cristofanilli, Young Kwang Chae, Francis J Giles, Sarki A Abdulkadir
PURPOSE: Small cell carcinoma of the prostate (SCCP) is an aggressive disease that can arise de novo or by transdifferentiation from prostate adenocarcinoma. Alterations in anaplastic lymphoma kinase (ALK) gene are involved in neuroblastoma, lung cancer, and other malignancies but its role in SCCP has not been documented. We describe a patient with refractory de novo SCCP with ALK F1174C activating mutation who obtained clinical benefit from treatment with ALK inhibitor. EXPERIMENTAL DESIGN: Next-generation sequencing (NGS) was used to analyze primary and circulating tumor DNA (ctDNA)...
March 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29549897/detection-of-ret-rearranged-during-transfection-variants-and-their-downstream-signal-molecules-in-ret-rearranged-lung-adenocarcinoma-patients
#4
Jeong-Oh Kim, Jung-Young Shin, Min Young Kim, Kyoung Hwa Son, Chan Kwon Jung, Tae-Jung Kim, Su Young Kim, Jae Kil Park, Sook Whan Sung, Sang Ju Bae, Hyun Jung Min, Jin-Hyoung Kang
BACKGROUND: We screened resected tumor tissues from patients with lung cancer for EGFR mutations, ALK rearrangements, and rearranged during transfection (RET) gene variants (including RET rearrangements and the Kinesin Family Member 5B (KIF5B)-RET fusion gene) using various methods including reverse transcription polymerase chain reaction (RT-PCR), transcript assays, fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC). We also examined the protein expression of associated downstream signaling molecules to assess the effect of these variants on patient outcome...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29548312/delayed-diagnosis-of-birt-hogg-dub%C3%A3-syndrome-due-to-marked-intrafamilial-clinical-variability-a-case-report
#5
E C Sattler, O K Steinlein
BACKGROUND: Birt-Hogg-Dubé syndrome is a genetic syndrome caused by mutations in the FLCN gene. The main symptoms are lung bullae and pneumothorax, benign and malignant kidney tumors, and facial fibrofolliculoma. The risk of pneumothorax is considerable between ages 20-40 years, but decreases markedly after this age range and first-time pneumothorax after age 50 years is rare. Fibrofolliculomas usually occur between ages 35 and 45 years, while the risk for kidney cancer increases steadily with age, starting in young adulthood...
March 16, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29517858/clinicopathological-features-of-younger-aged-%C3%A2-50-years-lung-adenocarcinoma-patients-harboring-the-eml4-alk-fusion-gene
#6
Takuro Kometani, Kenji Sugio, Atsushi Osoegawa, Takashi Seto, Yukito Ichinose
BACKGROUND: The EML4-ALK fusion gene has recently been identified as a driver mutation in a subset of non-small cell lung cancers. In subsequent studies, EML4-ALK has been detected in a low percentage of patients, and was associated with a lack of EGFR or KRAS mutations, younger age, and adenocarcinoma with acinar histology. Cases with the EML4-ALK fusion gene were examined to clarify the clinicopathological characteristics of young adenocarcinoma patients. METHODS: Between December 1998 and May 2009, 85 patients aged ≤ 50 with lung adenocarcinoma were treated at our hospital...
March 8, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29502124/a-prospective-observational-study-evaluating-the-correlation-of-c-met-expression-and-egfr-gene-mutation-with-response-to-erlotinib-as-second-line-treatment-for-patients-with-advanced-metastatic-non-small-cell-lung-cancer
#7
Cheol-Kyu Park, In-Jae Oh, Yoo-Duk Choi, Tae-Won Jang, Jeong-Eun Lee, Jeong-Seon Ryu, Shin-Yup Lee, Young-Chul Kim
OBJECTIVES: We aimed to evaluate the prevalence and predictive role of c-MET expression and EGFR mutation in the efficacy of erlotinib in non-small-cell lung cancer (NSCLC). METHODS: We prospectively recruited 196 patients with stage IV or recurrent NSCLC treated with erlotinib after failure of first-line chemotherapy. Immunohistochemistry was used to evaluate c-MET overexpression, silver in situ hybridization (SISH) to assess gene copy number, and real-time polymerase chain reaction to detect EGFR mutations, respectively, in tumor tissue...
March 2, 2018: Oncology
https://www.readbyqxmd.com/read/29496169/ophiopogonin-d-modulates-multiple-oncogenic-signaling-pathways-leading-to-suppression-of-proliferation-and-chemosensitization-of-human-lung-cancer-cells
#8
Jong Hyun Lee, Chulwon Kim, Seok-Geun Lee, Woong Mo Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
BACKGROUND: Ophiopogonin D (OP-D), a steroidal glycoside obtained from the Chinese medicinal plant Ophiopogonin japonicas (the root portion), has been traditionally used to treat fever, inflammation, cough, sputum etc. However, the detailed molecular mechanism(s) underlying its therapeutic actions is still unknown. HYPOTHESIS: Because nuclear factor-κB (NF-κB), PI3K/AKT, and activator protein-1 (AP-1) signaling cascades have significant functions in cell proliferation, inflammation, and angiogenesis in tumor cells, we hypothesized that OP-D may disrupt these signaling cascades to exert its anticancer effects in human lung-cancer cells...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29487705/mutations-in-dna-repair-genes-are-associated-with-increased-neo-antigen-load-and-activated-t-cell-infiltration-in-lung-adenocarcinoma
#9
Young Kwang Chae, Jonathan F Anker, Preeti Bais, Sandeep Namburi, Francis J Giles, Jeffrey H Chuang
Mutations in DNA repair genes lead to increased genomic instability and mutation frequency. These mutations represent potential biomarkers for cancer immunotherapy efficacy, as high tumor mutational burden has been associated with increased neo-antigens and tumor infiltrating lymphocytes. While mismatch repair mutations have successfully predicted response to anti-PD-1 therapy in colorectal and other cancers, they have not yet been tested for lung cancer, and few have investigated genes from other DNA repair pathways...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29484424/knockdown-of-end-binding-protein-1-induces-apoptosis-in-radioresistant-a549-lung-cancer-cells-via-p38-kinase-dependent-cox-2-upregulation
#10
Jeong-Hwa Baek, Ji-Hye Yim, Jie-Young Song, Hong-Duck Um, Jong Kuk Park, In-Chul Park, Jae-Sung Kim, Chang-Woo Lee, Eun-Hee Hong, Eun Ho Kim, Sang-Gu Hwang
The role of end-binding protein 1 (EB1) in lung cancer tumorigenesis and radiotherapy remains poorly understood. In the present study, we observed that EB1 was highly expressed in lung tumor tissues compared with normal non-tumor tissues based on immunohistochemical analysis of lung cancer tissue samples obtained from human tissue microarrays. EB1 was also highly overexpressed in radioresistant lung and cervical cancer cells, which exhibited increased cell death after EB1 silencing. The cytotoxicity induced by EB1 gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase...
February 22, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29460035/frequent-genomic-alterations-and-better-prognosis-among-young-patients-with-non-small-cell-lung-cancer-aged-40-years-or-younger
#11
X Pan, T Lv, F Zhang, H Fan, H Liu, Y Song
BACKGROUND: The subgroup of young patients with non-small-cell lung cancer (NSCLC) is poorly understood. We retrospectively studied the clinical characteristics, gene mutations, and outcomes of patients with NSCLC (aged ≤ 40 years). RESULTS: Of the 7494 patients with lung cancer diagnosed from February 2001 to October 2016, 252 aged ≤ 40 years showed NSCLC. We divided their cases into non-squamous cell carcinoma and squamous cell carcinoma groups according to their histology results...
February 19, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29448242/the-lncrna-epel-promotes-lung-cancer-cell-proliferation-through-e2f-target-activation
#12
Seong-Min Park, Eun-Young Choi, Dong-Hyuck Bae, Hyun Ahm Sohn, Seon-Young Kim, Youn-Jae Kim
BACKGROUND/AIMS: Recent studies have revealed that many long non-coding RNAs (lncRNAs) play oncogenic or tumor-suppressive roles in various cancers. Lung cancer is the leading cause of cancer-related death worldwide, and many lung cancer patients frequently relapse after surgery, even those in the early stages. However, the oncogenic or tumor-suppressive roles and clinical implications of lncRNAs in lung cancer have not been fully elucidated. METHODS: The association between an E2F-mediated cell proliferation enhancing lncRNA (EPEL) expression and lung cancer patient survival was accessed using public microarray data with clinical information...
February 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29440769/epithelial-mesenchymal-transition-emt-signature-is-inversely-associated-with-t-cell-infiltration-in-non-small-cell-lung-cancer-nsclc
#13
Young Kwang Chae, Sangmin Chang, Taeyeong Ko, Jonathan Anker, Sarita Agte, Wade Iams, Wooyoung M Choi, Kyoungmin Lee, Marcelo Cruz
Epithelial-mesenchymal transition (EMT) is able to drive metastasis during progression of multiple cancer types, including non-small cell lung cancer (NSCLC). As resistance to immunotherapy has been associated with EMT and immune exclusion in melanoma, it is important to understand alterations to T-cell infiltration and the tumor microenvironment during EMT in lung adenocarcinoma and squamous cell carcinoma. We conducted an integrated analysis of the immune landscape in NSCLCs through EMT scores derived from a previously established 16 gene signature of canonical EMT markers...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29410498/knockdown-of-spry4-and-spry4-it1-inhibits-cell-growth-and-phosphorylation-of-akt-in-human-testicular-germ-cell-tumours
#14
Mrinal K Das, Kari Furu, Herman F Evensen, Øyvind P Haugen, Trine B Haugen
Testicular germ cell tumour (TGCT) is the most common cancer in young men in large parts of the world, but the aetiology is mainly unknown. Genome-wide association studies have so far identified about 50 susceptibility loci associated with TGCT, including SPRY4. SPRY4 has shown tumour suppressor activity in several cancer cells, such as lung and prostate, while it was found to act as an oncogene in ovarian cancer. An intronic region within the SPRY4 gene produces a long non-coding RNA, SPRY4-IT1, which has been reported to act as an oncogene in melanoma, breast cancer, and colorectal cancer, and as a tumour suppressor in lung cancer...
February 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378266/association-of-pd-l1-expression-with-tumor-infiltrating-immune-cells-and-mutation-burden-in-high-grade-neuroendocrine-carcinoma-of-the-lung
#15
Hye Sook Kim, Jeong Hyeon Lee, Soo Jeong Nam, Chan-Young Ock, Jae-Woo Moon, Chong Woo Yoo, Geon Kook Lee, Ji-Youn Han
BACKGROUND: The immune microenvironment of high-grade neuroendocrine carcinoma (HGNEC) of the lung, including programmed death-ligand 1 (PD-L1) expression, has not been well characterized. METHODS: Based on immunohistochemistry (IHC) results, PD-L1 expression on tumor cells (TC) and tumor-infiltrating immune cells (IC) were scored as follows: TC0 and IC0 were defined as PD-L1 expression <1%, TC1 and IC1 as ≥1% but <10%, TC2 and IC2 as ≥10% but <50%, and TC3 and IC3 as ≥50%...
January 26, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29351247/b-type-and-complex-a-b-type-epicatechin-trimers-isolated-from-litchi-pericarp-aqueous-extract-show-high-antioxidant-and-anticancer-activity
#16
Yihui Gong, Fang Fang, Xin Zhang, Bin Liu, Honghui Luo, Zhen Li, Xuelian Zhang, Zhaoqi Zhang, Xuequn Pang
Litchi ( Litchi chinensis Sonn.) fruit is known for its rich source of phenolics. Litchi pericarp contains high levels of epicatechin that may form oligomers of various lengths. Except for several A or B type epicatechin dimers, other soluble oligomers have rarely been identified in the pericarp. Here, bioassay-guided column fractionation was applied to isolate bioactive phenolics from aqueous pericarp extract. A fraction (S3) was obtained by two rounds of Sephadex LH-20 column chromatography, and showed higher antioxidant activity and inhibition on the proliferation of human lung cancer cells (A549) than Litchi anthocyanins ...
January 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29348685/overexpression-of-adhesion-molecules-and-barrier-molecules-is-associated-with-differential-infiltration-of-immune-cells-in-non-small-cell-lung-cancer
#17
Young Kwang Chae, Wooyoung M Choi, William H Bae, Jonathan Anker, Andrew A Davis, Sarita Agte, Wade T Iams, Marcelo Cruz, Maria Matsangou, Francis J Giles
Immunotherapy is emerging as a promising option for lung cancer treatment. Various endothelial adhesion molecules, such as integrin and selectin, as well as various cellular barrier molecules such as desmosome and tight junctions, regulate T-cell infiltration in the tumor microenvironment. However, little is known regarding how these molecules affect immune cells in patients with lung cancer. We demonstrated for the first time that overexpression of endothelial adhesion molecules and cellular barrier molecule genes was linked to differential infiltration of particular immune cells in non-small cell lung cancer...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316740/benzo-a-pyrene-alters-the-expression-of-genes-in-a549-lung-cancer-cells-and-cancer-stem-cells
#18
Yesol Bak, Hui-Joo Jang, Ji-Hye Seo, Su-Hyun No, Jung-Il Chae, Jintae Hong, Do-Young Yoon
Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a principal component of cigarette smoke. B[a]P can cause lung carcinogenesis and plays a key role in lung cancer progression. The role of B[a]P has been reported in lung cancer, but its effects on lung cancer stem cells (CSCs) have not been investigated. Emerging evidence indicates that CSCs are associated with carcinogenesis, tumor initiation, relapse, and metastasis. Therefore, targeting CSCs to defeat cancer is a challenging issue in the clinic...
March 28, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29289609/regulatory-variants-in-cancer-related-pathway-genes-predict-survival-of-patients-with-surgically-resected-non-small-cell-lung-cancer
#19
Kyung Min Shin, Mi Jeong Hong, Shin Yup Lee, Cheng Cheng Jin, Sun Ah Baek, Jang Hyuck Lee, Jin Eun Choi, Hyo-Gyoung Kang, Won Kee Lee, Yangki Seok, Eung Bae Lee, Ji Yun Jeong, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Young Chul Kim, In Jae Oh, Kook Joo Na, Sukki Cho, Sanghoon Jheon, Jae Yong Park
BACKGROUND: We conducted this study to identify genetic variants in cancer-related pathway genes which can predict prognosis of NSCLC patients after surgery, using a comprehensive list of regulatory single nucleotide polymorphisms (SNPs) prioritized by RegulomeDB. METHOD: A total of 509 potentially functional SNPs in cancer-related pathway genes selected from RegulomeDB were evaluated. These SNPs were analyzed in a discovery set (n=354), and a replication study was performed in an independent set (n=772)...
March 10, 2018: Gene
https://www.readbyqxmd.com/read/29247826/cytostatic-hydroxycoumarin-ot52-induces-er-golgi-stress-and-stat3-inhibition-triggering-non-canonical-cell-death-and-synergy-with-bh3-mimetics-in-lung-cancer
#20
Jin-Young Lee, Oualid Talhi, Dongman Jang, Claudia Cerella, Anthoula Gaigneaux, Kyu-Won Kim, Jung Weon Lee, Mario Dicato, Khaldoun Bachari, Byung Woo Han, Artur M S Silva, Barbora Orlikova, Marc Diederich
Coumarins are natural compounds with antioxidant, anti-inflammatory and anti-cancer potential known to modulate inflammatory pathways. Here, non-toxic biscoumarin OT52 strongly inhibited proliferation of non-small cell lung cancer cells with KRAS mutations, inhibited stem-like characteristics by reducing aldehyde dehydrogenase expression and abrogated spheroid formation capacity. This cytostatic effect was characterized by cell cycle arrest and onset of senescence concomitant with endoplasmic reticulum and Golgi stress, leading to metabolic alterations...
March 1, 2018: Cancer Letters
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