keyword
https://read.qxmd.com/read/38519913/an-international-phase-ii-trial-and-immune-profiling-of-sbrt-and-atezolizumab-in-advanced-pretreated-colorectal-cancer
#1
JOURNAL ARTICLE
Antonin Levy, Daphné Morel, Matthieu Texier, Roger Sun, Jerome Durand-Labrunie, Maria E Rodriguez-Ruiz, Severine Racadot, Stéphane Supiot, Nicolas Magné, Stacy Cyrille, Guillaume Louvel, Christophe Massard, Loic Verlingue, Fanny Bouquet, Alberto Bustillos, Lisa Bouarroudj, Clément Quevrin, Céline Clémenson, Michele Mondini, Lydia Meziani, Lambros Tselikas, Rastilav Bahleda, Antoine Hollebecque, Eric Deutsch
BACKGROUND: Immuno-radiotherapy may improve outcomes for patients with advanced solid tumors, although optimized combination modalities remain unclear. Here, we report the colorectal (CRC) cohort analysis from the SABR-PDL1 trial that evaluated the PD-L1 inhibitor atezolizumab in combination with stereotactic body radiation therapy (SBRT) in advanced cancer patients. METHODS: Eligible patients received atezolizumab 1200 mg every 3 weeks until progression or unmanageable toxicity, together with ablative SBRT delivered concurrently with the 2nd cycle (recommended dose of 45 Gy in 3 fractions, adapted upon normal tissue tolerance constraint)...
March 23, 2024: Molecular Cancer
https://read.qxmd.com/read/38496840/a-novel-prognostic-signature-of-coagulation-related-genes-leveraged-by-machine-learning-algorithms-for-lung-squamous-cell-carcinoma
#2
JOURNAL ARTICLE
Guo-Sheng Li, Rong-Quan He, Zhi-Guang Huang, Hong Huang, Zhen Yang, Jun Liu, Zong-Wang Fu, Wan-Ying Huang, Hua-Fu Zhou, Jin-Liang Kong, Gang Chen
Coagulation-related genes (CRGs) have been demonstrated to be essential for the development of certain tumors; however, little is known about CRGs in lung squamous cell carcinoma (LUSC). In this study, we adopted CRGs to construct a coagulation-related gene prognostic signature (CRGPS) using machine learning algorithms. Using a set of 92 machine learning integrated algorithms, the CRGPS was determined to be the optimal prognostic signature (median C-index = 0.600) for predicting the prognosis of an LUSC patient...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496448/inflammation-promotes-aging-associated-oncogenesis-in-the-lung
#3
Catherine Pham-Danis, Shi B Chia, Hannah A Scarborough, Etienne Danis, Travis Nemkov, Emily K Kleczko, Andre Navarro, Andrew Goodspeed, Elizabeth A Bonney, Charles A Dinarello, Carlo Marchetti, Raphael A Nemenoff, Kirk Hansen, James DeGregori
BACKGROUND: Lung cancer is the leading cause of cancer death in the world. While cigarette smoking is the major preventable factor for cancers in general and lung cancer in particular, old age is also a major risk factor. Aging-related chronic, low-level inflammation, termed inflammaging, has been widely documented; however, it remains unclear how inflammaging contributes to increased lung cancer incidence. AIM: To establish connections between aging-associated changes in the lungs and cancer risk...
March 5, 2024: bioRxiv
https://read.qxmd.com/read/38484556/whole-exome-sequencing-and-machine-learning-germline-analysis-of-individuals-presenting-with-extreme-phenotypes-of%C3%A2-high-and-low-risk-of-developing-tobacco-associated-lung-adenocarcinoma
#4
JOURNAL ARTICLE
Ana Patiño-García, Elizabeth Guruceaga, Maria Pilar Andueza, Marimar Ocón, Jafait Junior Fodop Sokoudjou, Nicolás de Villalonga Zornoza, Gorka Alkorta-Aranburu, Ibon Tamayo Uria, Alfonso Gurpide, Carlos Camps, Eloísa Jantus-Lewintre, Maria Navamuel-Andueza, Miguel F Sanmamed, Ignacio Melero, Mohamed Elgendy, Juan Pablo Fusco, Javier J Zulueta, Juan P de-Torres, Gorka Bastarrika, Luis Seijo, Ruben Pio, Luis M Montuenga, Mikel Hernáez, Idoia Ochoa, Jose Luis Perez-Gracia
BACKGROUND: Tobacco is the main risk factor for developing lung cancer. Yet, while some heavy smokers develop lung cancer at a young age, other heavy smokers never develop it, even at an advanced age, suggesting a remarkable variability in the individual susceptibility to the carcinogenic effects of tobacco. We characterized the germline profile of subjects presenting these extreme phenotypes with Whole Exome Sequencing (WES) and Machine Learning (ML). METHODS: We sequenced germline DNA from heavy smokers who either developed lung adenocarcinoma at an early age (extreme cases) or who did not develop lung cancer at an advanced age (extreme controls), selected from databases including over 6600 subjects...
March 13, 2024: EBioMedicine
https://read.qxmd.com/read/38484369/a-comprehensive-investigation-on-the-receptor-bsg-expression-reveals-the-potential-risk-of-healthy-individuals-and-cancer-patients-to-2019-ncov-infection
#5
JOURNAL ARTICLE
Yongbiao Huang, Haiting Zhou, Yuan Wang, Lingyan Xiao, Wan Qin, Long Li
BACKGROUND: Coronavirus disease-2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly emerging coronavirus. BSG (basigin) is involved in the tumorigenesis of multiple tumors and recently emerged as a novel viral entry receptor for SARS-CoV-2. However, its expression profile in normal individuals and cancer patients are still unclear. METHODS: We performed a comprehensive analysis of the expression and distribution of BSG in normal tissues, tumor tissues, and cell lines via bioinformatics analysis and experimental verification...
March 13, 2024: Aging
https://read.qxmd.com/read/38473297/clinical-benefit-from-docetaxel-ramucirumab-is-not-associated-with-mutation-status-in-metastatic-non-small-cell-lung-cancer-patients-who-progressed-on-platinum-doublets-and-immunotherapy
#6
JOURNAL ARTICLE
Kang Qin, Kaiwen Wang, Shenduo Li, Lingzhi Hong, Priyadharshini Padmakumar, Rinsurongkawong Waree, Shawna M Hubert, Xiuning Le, Natalie Vokes, Kunal Rai, Ara Vaporciyan, Don L Gibbons, John V Heymach, J Jack Lee, Scott E Woodman, Caroline Chung, David A Jaffray, Mehmet Altan, Yanyan Lou, Jianjun Zhang
Docetaxel +/- ramucirumab remains the standard-of-care therapy for patients with metastatic non-small-cell lung cancer (NSCLC) after progression on platinum doublets and immune checkpoint inhibitors (ICIs). The aim of our study was to investigate whether the cancer gene mutation status was associated with clinical benefits from docetaxel +/- ramucirumab. We also investigated whether platinum/taxane-based regimens offered a better clinical benefit in this patient population. A total of 454 patients were analyzed (docetaxel +/- ramucirumab n=381; platinum/taxane-based regimens n=73)...
February 26, 2024: Cancers
https://read.qxmd.com/read/38469817/genome-wide-analysis-identified-sema4d-novel-candidate-gene-for-temperature-sensitivity-in-patients-with-non-small-cell-lung-cancer
#7
JOURNAL ARTICLE
Jung-Hyang Park, Eunbin Kwag, Mi-Kyung Jeong, So-Jung Park, Sanghun Lee, Hwa-Seung Yoo
BACKGROUND: In the era of precision medicine, individual temperature sensitivity has been highlighted. This trait has traditionally been used for cold-heat pattern identification to understand the inherent physical characteristics, which are influenced by genetic factors, of an individual. However, genome-wide association studies (GWASs) on this trait are limited. METHODS: Using genotype data from 90 patients with advanced non-small cell lung cancer (NSCLC) and epidermal growth factor receptor mutations, we performed a GWAS to assess the association between single nucleotide polymorphisms (SNPs) and temperature sensitivity, such as cold and heat scores...
2024: Integrative Cancer Therapies
https://read.qxmd.com/read/38464122/machine-learning-identifies-cell-free-dna-5-hydroxymethylation-biomarkers-that-detect-occult-colorectal-cancer-in-plco-screening-trial-subjects
#8
Diana C West-Szymanski, Zhou Zhang, Xiao-Long Cui, Krissana Kowitwanich, Lu Gao, Zifeng Deng, Urszula Dougherty, Craig Williams, Shannon Merkle, Matthew Moore, Chuan He, Marc Bissonnette, Wei Zhang
BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer-related mortality, and CRC detection through screening improves survival rates. A promising avenue to improve patient screening compliance is the development of minimally-invasive liquid biopsy assays that target CRC biomarkers on circulating cell-free DNA (cfDNA) in peripheral plasma. In this report, we identify cfDNA biomarker candidate genes bearing the epigenetic mark 5-hydroxymethylcytosine (5hmC) that diagnose occult CRC up to 36 months prior to clinical diagnosis using the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial samples...
February 26, 2024: bioRxiv
https://read.qxmd.com/read/38445462/methylation-status-of-mir-34a-and-mir-126-in-non-small-cell-lung-cancer-nsclc-tumor-tissues
#9
JOURNAL ARTICLE
Nazanin Mehrzad, Mohammad Saber Zamani, Amirabbas Rahimi, Masoud Shamaei, Morteza Karimipoor
BACKGROUND: Non-small cell lung cancer accounts for 85% of tumors of the lung and is a leading cause of cancer mortality worldwide. MiR-34a and miR-126 mainly act as tumor suppressors and are often downregulated in various cancers, including NSCLC. METHODS: The current study included 63 paraffin-embedded NSCLC and paired adjacent normal tissues. After DNA extraction and bisulfite treatment, the methylation status of miR-34a and miR-126 were evaluated using the MSP method...
September 3, 2023: Iranian Biomedical Journal
https://read.qxmd.com/read/38443832/loss-of-chromosome-y-in-regulatory-t-cells
#10
JOURNAL ARTICLE
Jonas Mattisson, Jonatan Halvardson, Hanna Davies, Bożena Bruhn-Olszewska, Paweł Olszewski, Marcus Danielsson, Josefin Bjurling, Amanda Lindberg, Ammar Zaghlool, Edyta Rychlicka-Buniowska, Jan P Dumanski, Lars A Forsberg
BACKGROUND: Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many forms of cancer. It has been suggested that the association between LOY and disease risk depends on what type of leukocyte is affected with Y loss, with prostate cancer patients showing higher levels of LOY in CD4 + T lymphocytes. In previous studies, Y loss has however been observed at relatively low levels in this cell type...
March 5, 2024: BMC Genomics
https://read.qxmd.com/read/38434971/exploration-of-radiotherapy-strategy-for-brain-metastasis-patients-with-driver-gene-positivity-in-lung-cancer
#11
JOURNAL ARTICLE
Qian Bi, Xin Lian, Jing Shen, Fuquan Zhang, Tao Xu
Objective: To assess the disparities in effectiveness and identify outcome predictors in the treatment of a targeted-first and radiotherapy-first regimen with driver gene-positive lung cancer brain metastases. Materials and Methods: This retrospective study analyzed patients with driver gene-positive lung cancer brain metastases who received first-targeted and first-radiotherapy regimens, respectively, with SIB-WBRT (whole brain tissue 40 Gy/20 fractions, tumor tissue boosted to 56-60 Gy/20 fractions) and local irradiation (prescription dose range of 20-60 Gy/2-25 fractions, most commonly delivered as 30 Gy/5 fractions, with a BED range of 28-100...
2024: Journal of Cancer
https://read.qxmd.com/read/38433052/-intraductal-carcinomas-of-the-salivary-glands-a-clinicopathological-and-molecular-genetic-analysis-of-twenty-seven-cases
#12
JOURNAL ARTICLE
Q Sun, J J Sun, M Wang, L Zhang, X W Zhang, J G Wei, L F Kong, J Li
Objective: To investigate the clinicopathological features, molecular genetic features, and differential diagnosis of intraductal carcinomas (IDC) of the salivary glands. Methods: Twenty-five cases of salivary gland IDC diagnosed at the Department of Oral Pathology, Shanghai Ninth People's Hospital and two cases from Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, China from January 2008 to July 2023 were collected. Their clinical and pathological features were analyzed retrospectively...
March 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/38430689/exploring-the-molecular-and-immune-landscape-of-lung-cancer-associated-with-cystic-airspaces
#13
JOURNAL ARTICLE
Xiang Zheng, Li Qiu, Ying Huang, Ran Cheng, Sihe Huang, Ke Xu, Weipeng Cai, Yu Deng, Wei Wang, Xi Zhong, Fei Cui, Zhexue Hao, Jun Liu
To explore the molecular biological characteristics of lung cancer associated with cystic airspaces (LCCA) and its potential roles on prognosis. A total of 165 LCCAs and 201 non-LCCAs were enrolled in this study. Bulk RNA sequencing was implemented in eight LCCAs and nine non-LCCAs to explore the differentially expressed genes. TCGA data were used to analyze LCCA-specific genes that associated with overall survival (OS). The median age was 60 (IQR 53 to 65) years in LCCA cohort. We found LCCA were predominant in men and had less visceral pleura invasion (VPI) or lympho-vascular invasion (LVI)...
March 1, 2024: Molecular Immunology
https://read.qxmd.com/read/38421462/primary-pulmonary-myxoid-sarcoma-with-ewsr1-creb1-fusion-a-literature-review
#14
REVIEW
Xinyu Miao, Jing Chen, Lan Yang, Hongyang Lu
PURPOSE: This review primarily aims to review the epidemiology, clinical characteristics, imaging, pathology, immunohistochemistry, diagnosis, differential diagnosis, treatment, and prognosis of Primary pulmonary myxoid sarcoma (PPMS) with EWS RNA binding protein 1::cAMP response element binding protein 1 (EWSR1::CREB1) fusion. It provides reference for the diagnosis and treatment of this disease. METHODS: Retrospectively collected the literature about PPMS with EWSR1::CREB1 fusion, its clinical, radiology, histology, molecular characteristics and current treatment strategies were collated and analyzed...
February 29, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38420798/the-role-of-cd8a-in-the-immune-microenvironment-of-breast-cancer
#15
JOURNAL ARTICLE
Jian Chu, Shan Tang, Tangya Li, Huiwen Fan
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer (BC), and it is often associated with a high tumor grade, a younger age at diagnosis, and a low survival rate. Conventional endocrine and anti-HER-2 therapies are usually ineffective against TNBC, creating treatment challenges and resulting in a poor prognosis. Hence, new targets and treatment strategies for TNBC are urgently required. METHODS: The GSE102818 dataset was used to identify differentially expressed genes (DEGs) between primary BC and metastatic BC lesions...
February 21, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38412388/cancer-risks-associated-with-tp53-pathogenic-variants-maximum-likelihood-analysis-of-extended-pedigrees-for-diagnosis-of-first-cancers-beyond-the-li-fraumeni-syndrome-spectrum
#16
MULTICENTER STUDY
Cristina Fortuno, Bing-Jian Feng, Courtney Carroll, Giovanni Innella, Wendy Kohlmann, Conxi Lázaro, Joan Brunet, Lidia Feliubadaló, Silvia Iglesias, Mireia Menéndez, Alex Teulé, Mandy L Ballinger, David M Thomas, Ainsley Campbell, Mike Field, Marion Harris, Judy Kirk, Nicholas Pachter, Nicola Poplawski, Rachel Susman, Kathy Tucker, Mathew Wallis, Rachel Williams, Elisa Cops, David Goldgar, Paul A James, Amanda B Spurdle
PURPOSE: Establishing accurate age-related penetrance figures for the broad range of cancer types that occur in individuals harboring a pathogenic germline variant in the TP53 gene is essential to determine the most effective clinical management strategies. These figures also permit optimal use of cosegregation data for classification of TP53 variants of unknown significance. Penetrance estimation can easily be affected by bias from ascertainment criteria, an issue not commonly addressed by previous studies...
February 2024: JCO Precision Oncology
https://read.qxmd.com/read/38402182/emerging-trends-in-the-coexistence-of-primary-lung-cancer-and-hematologic-malignancy-a-comprehensive-analysis-of-clinicopathological-features-and-genetic-abnormalities
#17
JOURNAL ARTICLE
Mengchen Lyu, Lifeng Luo, Ling Zhou, Xiangran Feng, Jin Yang, Ziwei Xu, Xianwen Sun, Zhiyao Bao, Xiaofei Wang, Beili Gao, Yi Xiang
BACKGROUND: The incidence of multiple primary cancers (MPC), especially involving primary lung cancer (PLC) and primary hematologic malignancies (PHM), is rising. This study aims to analyze clinicopathological features, gene abnormalities, and prognostic outcomes in individuals diagnosed with PLC-PHM MPC. METHODS: A retrospective analysis included 89 patients diagnosed with PLC-PHM MPC at the Respiratory or Hematology Departments of Ruijin Hospital from 2003 to 2022 (a total of 842,047 people)...
February 24, 2024: Cancer Cell International
https://read.qxmd.com/read/38397754/oxidative-damage-and-telomere-length-as-markers-of-lung-cancer-development-among-chronic-obstructive-pulmonary-disease-copd-smokers
#18
JOURNAL ARTICLE
Elizabeth Córdoba-Lanús, Luis M Montuenga, Angélica Domínguez-de-Barros, Alexis Oliva, Delia Mayato, Ana Remírez-Sanz, Francisca Gonzalvo, Bartolomé Celli, Javier J Zulueta, Ciro Casanova
Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallmark of aging, and 8-OHdG concentrations, indicative of oxidative DNA damage, as risk biomarkers of LC was evaluated in COPD patients three years prior to LC diagnosis. Relative telomere length measured using qPCR and serum levels of 8-OHdG were determined at the baseline in 99 COPD smokers (33 with LC and 66 age-matched COPD without LC as controls)...
January 26, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38395390/elevated-expression-of-complement-factor-i-in-lung-cancer-cells-associates-with-shorter-survival-potentially-via-non-canonical-mechanism
#19
JOURNAL ARTICLE
Anna Felberg, Michał Bieńkowski, Tomasz Stokowy, Kamil Myszczyński, Zuzanna Polakiewicz, Kamila Kitowska, Rafał Sądej, Frida Mohlin, Alicja Kuźniewska, Daria Kowalska, Grzegorz Stasiłojć, Ilse Jongerius, Robbert Spaapen, Miguel Mesa-Guzman, Luis M Montuenga, Anna M Blom, Ruben Pio, Marcin Okrój
While numerous membrane-bound complement inhibitors protect the body's cells from innate immunity's autoaggression, soluble inhibitors like complement factor I (FI) are rarely produced outside the liver. Previously, we reported the expression of FI in non-small cell lung cancer (NSCLC) cell lines. Now, we assessed the content of FI in cancer biopsies from lung cancer patients and associated the results with clinicopathological characteristics and clinical outcomes. Immunohistochemical staining intensity did not correlate with age, smoking status, tumor size, stage, differentiation grade, and T cell infiltrates, but was associated with progression-free survival (PFS), overall survival (OS) and disease-specific survival (DSS)...
February 21, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/38394494/efficacy-of-immune-checkpoint-inhibitors-in-smarca4-deficient-and-tp53-mutant-undifferentiated-lung-cancer
#20
JOURNAL ARTICLE
Jianxin Chen, Qinhong Zheng, Junhui Wang, Xueli Zhang, Yingguo Lv
The present study was conducted to characterize the clinicopathologic characteristics, immunohistochemical staining results, and immune checkpoint inhibitors (ICIs) efficacy in patients with SMARCA4-deficient/TP53 mutant lung cancer. Patients diagnosed with advanced or metastatic undifferentiated lung cancer harboring SMARCA4-deficient and TP53 mutations, however, without targetable sensitive mutations were retrieved from the electronic medical record system. Descriptive statistics were used to describe the baseline characteristics and clinical features including age, gender, eastern cooperative oncology group performance status, disease stage, smoking status, chief complaint, site of the primary mass, tumor size, gross type, symptoms, local invasion, and metastatic sizes...
February 23, 2024: Medicine (Baltimore)
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