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https://www.readbyqxmd.com/read/29452439/assessment-of-function-after-free-tissue-transfer-to-the-lower-extremity-for-chronic-wounds-using-the-lower-extremity-functional-scale
#1
Reuben A Falola, Chrisovalantis Lakhiani, Jocelyn Green, Siya Patil, Brandon Jackson, Rachel Bratescu, Ersilia Anghel, John S Steinberg, Paul J Kim, Christopher E Attinger, Karen K Evans
BACKGROUND: Free tissue transfer is one option for preservation of form and function in the native limb, in the setting of soft tissue paucity. However, the data on patient functionality after microvascular intervention is inconsistently reported. The Lower Extremity Function Scale (LEFS) measures patient-reported difficulty in carrying out 20 physical activities, on a Likert scale, the sum of which correlates with descriptive functional stages of 1-5. We assess limb functionality in this cohort of microvascular patients using the LEFS survey...
February 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29452288/repetitive-tlr-3-activation-in-the-lung-induces-skeletal-muscle-adaptations-and-cachexia
#2
Ted G Graber, Brandy L Rawls, Bing Tian, William J Durham, Camille R Brightwell, Allan R Brasier, Blake B Rasmussen, Christopher S Fry
Due to immunosenescence, older adults are particularly susceptible to lung-based viral infections, with increased severity of symptoms in those with underlying chronic lung disease. Repeated respiratory viral infections produce lung maladaptations, accelerating pulmonary dysfunction. Toll like 3 receptor (TLR3) is a membrane protein that senses exogenous double-stranded RNA to activate the innate immune response to a viral infection. Polyinosinic-polycytidylic acid [poly(I:C)] mimics double stranded RNA and has been shown to activate TLR3...
February 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29452153/functionalization-of-nanodiamond-with-vitamin-e-tpgs-to-facilitate-oral-absorption-of-curcumin
#3
Bingchao Cheng, Hao Pan, Dandan Liu, Dongyang Li, Jinyu Li, Shihui Yu, Guoxin Tan, Weisan Pan
The purpose of this work was to develop a D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) decorated nanodiamond (ND) system loading water-insoluble curcumin (ND/CUR/TPGS) to improve the colloidal dispersity and oral bioavailability of the preparation. CUR was physically loaded into ND clusters, then TPGS was coated to the ND/CUR complex forming amorphous nanostructure on the interparticle nanocage of the ND substrate. The formulation of the nanocomplexes was optimized using response surface methodology, and the optimal ND/CUR/TPGS showed small particle size (196...
February 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29451983/reinforcing-mucus-barrier-properties-with-low-molar-mass-chitosans
#4
Sujit Kootala, Luimar Filho, Vaibhav Srivastava, Victoria Linderberg, Amani Moussa, Laurent David, Stéphane Trombotto, Thomas Crouzier
The mucus gel covers the wet epithelia that forms the inner lining of the body. It constitutes our first line of defense protecting the body from infections and other deleterious molecules. Failure of the mucus barrier can lead to the inflammation of the mucosa such as in inflammatory bowel diseases. Unfortunately, there are no effective strategies that reinforce the mucus barrier properties to recover or enhance its ability to protect the epithelium. Herein, we describe a mucus engineering approach that addresses this issue where we physically crosslink the mucus gel with low molar mass chitosan variants to reinforce its barrier functions...
February 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29451811/role-of-tendoscopy-in-treating-stage-ii-posterior-tibial-tendon-dysfunction
#5
Alessio Bernasconi, Francesco Sadile, Matthew Welck, Nazim Mehdi, Julien Laborde, François Lintz
BACKGROUND: Stage II tibialis posterior tendon dysfunction (PTTD) resistant to conservative therapies is usually treated with invasive surgery. Posterior tibial tendoscopy is a novel technique being used in the assessment and treatment of posterior tibial pathology. The aims of this study were (1) to clarify the role of posterior tibial tendon tendoscopy in treating stage II PTTD, (2) to arthroscopically classify spring ligament lesions, and (3) to compare the arthroscopic assessment of spring ligament lesions with magnetic resonance imaging (MRI) and ultrasonographic (US) data...
February 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29451795/physisorption-of-h-2-on-fullerenes-and-the-solvation-of-c-60-by-hydrogen-clusters-at-finite-temperature-a-theoretical-assessment
#6
Florent Calvo, Ersin Yurtsever, Adem Tekin
The interaction between hydrogen and carbonaceous nanostructures is of fundamental interest in various areas of physical chemistry. In this contribution we have revisited the physisorption of hydrogen molecules and H2 clusters on fullerenes, following a first-principles approach in which the interaction is quantitatively evaluated for the C20 system using high-level electronic structure methods. Relative to coupled cluster data at the level of single, double, and perturbative triple excitations [CCSD(T)] taken as benchmark, the results for rotationally averaged physisorbed H2 show a good performance of MP2 variants and symmetry-adapted perturbation theory (SAPT), but significant deviations and basis set convergence issues are found for dispersion-corrected density functional theory (DFT)...
February 16, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29451662/what-clinical-functional-and-psychological-factors-before-treatment-are-predictors-of-poor-quality-of-life-in-cancer-patients-at-the-end-of-chemotherapy
#7
Ariella Sebastião Mangia, Nara Lisiane de Oliveira Coqueiro, Fernanda Cabral Azevedo, Hiago Tomaz da Silva Araujo, Elizandra de Oliveira Amorim, Cibelli Navarro Rodrigues Alves, Calvino Camargo, Allex Jardim da Fonseca
OBJECTIVE: To correlate physical activity level (PAL), functional capacity and psychological state with quality of life (QoL) in cancer patients undergoing chemotherapy (CT). METHOD: Observational cohort study. Patients (n=121) with any primary cancer site with indications of chemotherapy with palliative or curative intent were evaluated at three moments: 1) patient admission (week 0), before chemotherapy; 2) week 8; 3) end of CT. Data were collected regarding QoL, PAL, clinical data, functional capacity (short walking distance test, sitting-rising test, isometric manual gripping force), and anxiety and depression tests...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451638/-association-between-health-anthropometric-indexes-with-physical-fitness-in-physically-active-elderly-women
#8
Pablo Valdés-Badilla, Andrés Godoy-Cumillaf, Jenny Ortega-Spuler, Tomás Herrera-Valenzuela, Samuel Durán-Agüero, José Zapata-Bastias, Rodrigo Vargas-Vitoria, Eduardo Guzmán-Muñoz, Antonio López-Fuenzalida
OBJECTIVE: To associate health anthropometric indexes with physical fitness of elderly women (EW) who participate in physical exercise workshops. MATERIALS AND METHODS: 272 Chilean women over 60 years took part in the study. The variables studied were BMI, waist circumference (WC), waist-height index (WHI) and physical fitness (PF). Correlations were made through the Pearson or Spearman coefficient, and bivariate associations using Pearson's Chi-square and the Fisher's exact test, considering p<0...
November 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29451120/an-in-silico-framework-to-analyze-the-anisotropic-shear-wave-mechanics-in-cardiac-shear-wave-elastography
#9
Annette Caenen, Mathieu Pernot, Mathias Peirlinck, Luc Mertens, Abigail Swillens, Patrick Segers
Shear wave elastography (SWE) is a potential tool to non-invasively assess cardiac muscle stiffness. This study focused on the effect of the orthotropic material properties and mechanical loading on the performance of cardiac SWE, as it is known that these factors contribute to complex 3D anisotropic shear wave propagation. To investigate the specific impact of these complexities, we constructed a finite element model with an orthotropic material law subjected to different uniaxial stretches to simulate SWE in the stressed cardiac wall...
February 16, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29451094/growth-and-optimization-of-carbon-nanotubes-in-powder-activated-carbon-for-an-efficient-removal-of-methylene-blue-from-aqueous-solution
#10
Haiyam Mohammed Alayan, Mohammed Abdulhakim Alsaadi, Mohammed Khaled AlOmar, Mohd Ali Hashim
This work demonstrated the synthesis of carbon nanotubes (CNTs) on powder activated carbon (PAC) impregnated with Ni-catalyst through chemical vapor deposition. The optimized effects of reaction temperature, time and feedstock flow rates on CNT growth were examined. Potassium permanganate (KMnO 4 ) and potassium permanganate in acidic solution (KMnO 4 /H 2 SO 4 ) were used to functionalize CNTs samples. A primary screening of methylene blue (MB) adsorption was conducted. The chemical, physical and morphological properties of the adsorbent with the highest removal efficiency were investigated using FESEM, EDX, TEM, BET surface area, RAMAN, TGA, FTIR, and zeta potential...
February 16, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29451072/social-support-for-exercise-as-a-predictor-of-weight-and-physical-activity-status-among-puerto-rican-and-mexican-men-results-from-the-latino-men-s-health-initiative
#11
Meredith R Craven, Laurie Keefer, Alfred Rademaker, Amanda Dykema-Engblade, Lisa Sanchez-Johnsen
Social support is an important factor in increasing positive health outcomes and positive health behaviors across a variety of disease states including obesity. However, research examining the relationship between social support for exercise and weight and physical activity status, particularly among Latino men, is lacking. This paper examined whether social support for exercise predicted weight and physical activity status and whether the direction of these relationships differ as a function of Hispanic/Latino background (Puerto Rican/Mexican)...
February 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29451066/psychometric-properties-of-mdhaq-rapid3-in-patients-with-systemic-lupus-erythematosus
#12
N Annapureddy, D Giangreco, H Devilliers, J A Block, M Jolly
Background The Multidimensional Health Assessment Questionnaire (MDHAQ) is a patient-reported outcome (PRO) tool that includes the Routine Assessment of Patient Index Data 3 (RAPID3), an index that can be calculated at the point of care. The objective of this study was to perform psychometric analyses of MDHAQ/RAPID3 to study its measurement properties in systemic lupus erythematosus (SLE). Methods The MDHAQ was completed by 161 SLE patients in routine care, along with LupusPRO (a disease-specific PRO). The SLE disease-specific activity index (SELENA-SLEDAI) and damage (SDI) were assessed...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29450970/direct-imaging-of-space-charge-accumulation-and-work-function-characteristics-of-functional-organic-interfaces
#13
Pablo F Siles, Mirunalini Devarajulu, Feng Zhu, Oliver G Schmidt
The tailoring of organic systems is crucial to further extend the efficiency of charge transfer mechanisms and represents a cornerstone for molecular device technologies. However, this demands control of electrical properties and understanding of the physics behind organic interfaces. Here, a quantitative spatial overview of work function characteristics for phthalocyanine architectures on Au substrates is provided via kelvin probe microscopy. While macroscopic investigations are very informative, the current approach offers a nanoscale spatial rendering of electrical characteristics which is not possible to attain via conventional techniques...
February 16, 2018: Small
https://www.readbyqxmd.com/read/29450926/macroscopic-adhesion-of-thermoreversible-abc-triblock-copolymer-based-hydrogels-via-boronic-acid-sugar-complexation
#14
Ryota Tamate, Kotomi Takahashi, Takeshi Ueki, Aya Mizutani Akimoto, Ryo Yoshida
Two complementary thermoreversible ABC triblock copolymers containing either phenylboronic acids with low pK a values or galactosyl groups in the hydrophilic B blocks are synthesized by sequential reversible addition-fragmentation chain transfer polymerization and subsequent modification of the functional groups. Both ABC triblock copolymers undergo reversible sol-to-gel transitions upon temperature change and form physically cross-linked hydrogels under physiological conditions. Furthermore, the spontaneous adhesion of these thermoreversible hydrogels via the formation of boronic esters between the phenylboronic acid and galactosyl groups under physiological conditions is realized for the first time...
February 16, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29450863/using-self-reported-patient-experiences-to-understand-patient-burden-learnings-from-digital-patient-communities-in-ankylosing-spondylitis
#15
Prashanth Sunkureddi, Dawn Gibson, Stephen Doogan, John Heid, Samir Benosman, Yujin Park
INTRODUCTION: Online communities contain a wealth of information containing unsolicited patient experiences that may go beyond what is captured by guided surveys or patient-reported outcome (PRO) instruments used in clinical settings. This study described patient experiences reported online to better understand the day-to-day disease burden of ankylosing spondylitis (AS). METHODS: Unguided, English-language patient narratives reported between January 2010 and May 2016 were collected from 52 online sources (e...
February 15, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29450856/hysterectomy-and-perceived-physical-function-in-middle-aged-australian-women-a-20-year-population-based-prospective-cohort-study
#16
Louise F Wilson, Nirmala Pandeya, Julie Byles, Gita D Mishra
PURPOSE: Hysterectomy is one of the most common gynaecological procedures worldwide. Changes in endocrine function may impact age-associated decline in physical function and these changes may be accelerated by hysterectomy. The aim of this study was to investigate associations between hysterectomy status and self-reported physical function limitations. METHODS: Our study sample (n = 8624) came from the mid-cohort (born 1945-1950) of the Australian Longitudinal Study on Women's Health (ALSWH)...
February 15, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29450833/assessing-the-importance-of-treatment-goals-in-patients-with-psoriasis-analytic-hierarchy-process-vs-likert-scales
#17
Mandy Gutknecht, Marion Danner, Marthe-Lisa Schaarschmidt, Christian Gross, Matthias Augustin
BACKGROUND: To define treatment benefit, the Patient Benefit Index contains a weighting of patient-relevant treatment goals using the Patient Needs Questionnaire, which includes a 5-point Likert scale ranging from 0 ("not important at all") to 4 ("very important"). These treatment goals have been assigned to five health dimensions. The importance of each dimension can be derived by averaging the importance ratings on the Likert scales of associated treatment goals...
February 15, 2018: Patient
https://www.readbyqxmd.com/read/29450764/impact-of-well-being-interventions-for-siblings-of-children-and-young-people-with-a-chronic-physical-or-mental-health-condition-a-systematic-review-and-meta-analysis
#18
REVIEW
Mhairi McKenzie Smith, Snehal Pinto Pereira, Lynette Chan, Charlotte Rose, Roz Shafran
Siblings of children and young people with a chronic illness are at increased risk of poor psychological functioning. A number of studies have attempted to implement and evaluate interventions targeting the psychological well-being of this at-risk group. This systematic review summarises the evidence regarding psychological functioning of siblings following an intervention targeting their well-being. The meta-analysis considered behaviour and knowledge, two of the most frequently studied outcomes. The following databases were used: PsycINFO, EMBASE, CINAHL, PubMed, Scopus and Web of Science...
February 15, 2018: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/29450736/health-and-quality-of-life-differ-between-community-living-older-people-with-and-without-remaining-teeth-who-recently-received-formal-home-care-a-cross-sectional-study
#19
A R Hoeksema, L L Peters, G M Raghoebar, H J A Meijer, A Vissink, A Visser
OBJECTIVE: To assess oral health, health, and quality of life (QoL) of care-dependent community-living older people with and without remaining teeth who recently received formal home care. MATERIALS AND METHODS: For this cross-sectional observational study, community-living older people (≥ 65 years), who recently (< 6 months) received formal home care, were interviewed with validated questionnaires and underwent an oral examination. Oral health, general health, medicines usage, frailty (Groningen Frailty Indicator), cognition (Minimal Mental State Examination), QoL (RAND 36), and oral health-related QoL (Oral Health Impact Profile-14) were assessed...
February 15, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29450422/remarkable-structural-effects-on-the-complexation-of-actinides-with-h-phosphonates-a-combined-experimental-and-quantum-chemical-study
#20
Aditi Chandrasekar, Brahmmananda Rao C V S, Mahesh Sundararajan, Tapan K Ghanty, N Sivaraman
The structural effects of the carbon chain on the extraction of actinides by organo-phosphorus extractants have been examined experimentally and by computation. Branched butyl H-phosphonates and their linear chain isomer, n-butyl H-phosphonate (DBHP), were synthesised and characterised using IR, NMR and GC-MS techniques. Their physical properties viz. viscosity, density and aqueous solubility have been examined. DBHP, Di-iso-butyl H phosphonate (DiBHP) and Di-sec-butyl H phosphonate (DsBHP) were employed for the extraction of uranium and americium ions from nitric acid...
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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