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https://www.readbyqxmd.com/read/28214955/ranibizumab-versus-aflibercept-for-macular-edema-due-to-central-retinal-vein-occlusion-18-month-results-in-real-life-data
#1
Irini Chatziralli, George Theodossiadis, Marilita M Moschos, Panagiotis Mitropoulos, Panagiotis Theodossiadis
PURPOSE: The objective of this study was to compare the anatomical and functional outcomes of ranibizumab versus aflibercept for the treatment of macular edema due to central retinal vein occlusion (CRVO) in routine clinical practice. METHODS: Participants in this observational study included 62 treatment-naïve patients with CRVO who received intravitreal injections of either ranibizumab or aflibercept. The demographic data, best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) characteristics were evaluated at baseline and at months 1, 2, 3, 6, 12 and 18 post-treatment...
February 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28210181/causes-of-irreversible-unilateral-or-bilateral-blindness-in-the-al-baha-region-of-the-kingdom-of-saudi-arabia
#2
Huda Farhan Alghamdi
PURPOSE: To determine the causes of irreversible unilateral and bilateral blindness that cannot be rehabilitated medically, optically nor surgically in Al Baha province, Kingdom of Saudi Arabia. METHODS: There were a retrospective chart review and examination of patients presenting to King Fahad Hospital Al Baha, Saudi Arabia, with unilateral or bilateral blindness from June 2011 to September 2011. Blindness was defined as best corrected visual acuity (BCVA) of less than 0...
July 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28207609/ischemic-central-retinal-vein-occlusion-in-the-anti-vascular-endothelial-growth-factor-era
#3
Emily K Tam, Pamela Golchet, Madeline Yung, Francis C DeCroos, Marc Spirn, Lydia Lehmann-Clarke, Aude Ambresin, Irena Tsui
PURPOSE: Anti-vascular endothelial growth factor therapy has improved the prognosis for patients with central retinal vein occlusion (CRVO). However, most studies published to date exclude ischemic CRVO. The purpose of this study was to describe the outcome in eyes with ischemic CRVO treated with anti-vascular endothelial growth factor therapy. METHODS: Thirty-seven patients with ischemic CRVO from 3 centers were followed for at least 6 months. Data on patient demographic, vision status, and anti-vascular endothelial growth factor treatments were collected...
February 15, 2017: Retina
https://www.readbyqxmd.com/read/28203470/unusual-presentation-of-type-1-idiopathic-macular-telangiectasia
#4
Zaïnab Bentaleb Machkour, Philippe Denis, Laurent Kodjikian
Purpose. To report unusual presentation of type 1A idiopathic macular telangiectasia (IMT). Methods. Two middle-aged women with bilateral IMT were examined. Results. Both patients presented with a gradual vision loss in both eyes. Fundus examination was unremarkable in one case and showed small macular telangiectasia in both eyes in the other case. Fluorescein angiography (FA) revealed early bilateral macular punctuated hyperfluorescence corresponding to the dilated capillaries in both cases. FA and fundus examination confirmed also the absence of vascular abnormalities in the middle or anterior fundus periphery in one case...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28203192/docetaxel-retinopathy-a-case-report
#5
Sylvia Nghiem-Buffet, Salomon Yves Cohen, Audrey Giocanti-Auregan
BACKGROUND: To report the use of En-face optical coherence tomography (OCT) in a patient treated with docetaxel and tamoxifen for breast cancer for the detection of macular edema (ME) without evidence of leakage on fluorescein angiography (FA). CASE PRESENTATION: A 52-year-old woman treated for breast cancer presented with bilateral visual loss for 2 months. FA showed no significant leakage while spectral-domain OCT scans of both eyes showed foveolar and parafoveolar cystic spaces in a moderately thickened macula...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28196198/en-face-doppler-optical-coherence-tomography-measurement-of-total-retinal-blood-flow-in-diabetic-retinopathy-and-diabetic-macular-edema
#6
ByungKun Lee, Eduardo A Novais, Nadia K Waheed, Mehreen Adhi, Talisa E de Carlo, Emily D Cole, Eric M Moult, WooJhon Choi, Mark Lane, Caroline R Baumal, Jay S Duker, James G Fujimoto
Importance: Alterations in ocular blood flow play an important role in the pathogenesis and progression of diabetic retinopathy (DR). However, the measurement of retinal blood flow in clinical studies has been challenging. En face Doppler optical coherence tomography (OCT) provides an effective method for measuring total retinal blood flow (TRBF) in the clinic. Objective: To investigate TRBF in eyes with DR of varying severity, with or without diabetic macular edema (DME), using en face Doppler OCT...
February 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28196059/quantification-of-intraretinal-hard-exudates-in-eyes-with-diabetic-retinopathy-by-optical-coherence-tomography
#7
Sowmya Srinivas, Muneeswar G Nittala, Amirhossein Hariri, Maximilian Pfau, Julie Gasperini, Michael Ip, SriniVas R Sadda
PURPOSE: To evaluate the reproducibility of intraretinal hard exudate (HE) quantification from spectral domain optical coherence tomography (SD-OCT) images of eyes with diabetic retinopathy (DR). METHODS: Cases with diabetic macular edema were enrolled. The area of HE obtained by B-scan segmentation was compared with the area obtained by en face segmentation. RESULTS: The mean ± SD for the HE area was 1.78 ± 1.37 mm with B-scan segmentation and 0...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28196056/effect-of-an-intravitreal-dexamethasone-implant-on-diabetic-macular-edema-after-cataract-surgery
#8
Pilar Calvo, Antonio Ferreras, Fadwa Al Adel, Wantanee Dangboon, Michael H Brent
PURPOSE: To analyze the effects of a dexamethasone intravitreal implant (DEX; Ozurdex 700 μg; Allergan) administered immediately after cataract surgery in diabetic patients. METHODS: This prospective, single-arm, open label study (NCT01748487 at ClinicalTrials.gov) involved Type 2 diabetic patients with at least mild diabetic retinopathy (DR) who underwent cataract surgery and DEX insertion after phacoemulsification, and intraocular lens implantation were enrolled...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28196053/choroidal-thickness-in-diabetic-retinopathy-assessed-with-swept-source-optical-coherence-tomography
#9
Inês Laíns, Katherine E Talcott, Ana R Santos, João H Marques, Pedro Gil, João Gil, João Figueira, Deeba Husain, Ivana K Kim, Joan W Miller, Rufino Silva, John B Miller
PURPOSE: To compare the choroidal thickness (CT) of diabetic eyes (different stages of disease) with controls, using swept-source optical coherence tomography. METHODS: A multicenter, prospective, cross-sectional study of diabetic and nondiabetic subjects using swept-source optical coherence tomography imaging. Choroidal thickness maps, according to the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, were obtained using automated software. Mean CT was calculated as the mean value within the ETDRS grid, and central CT as the mean in the central 1 mm...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28195620/significant-bilateral-response-in-diabetic-macular-edema-after-single-unilateral-intravitreal-aflibercept-injection
#10
Ehsan Rahimy, Omondi Nyong'o, Theodore Leng
A 61-year-old patient with bilateral, treatment-naïve, diffuse diabetic macular edema (DME) that had been progressing during the previous 12 months received a single intravitreal injection of aflibercept (Eylea; Regeneron, Tarrytown, NY) to the left eye. At 2-week follow-up, noticeable bilateral improvement of the DME was observed by spectral-domain optical coherence tomography imaging with commensurate improvement of visual acuity to 20/30 bilaterally. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:167-169...
1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28195619/efficacy-of-the-intravitreal-sustained-release-dexamethasone-implant-for-diabetic-macular-edema-refractory-to-anti-vascular-endothelial-growth-factor-therapy-meta-analysis-and-clinical-implications
#11
Zainab Khan, Robin K Kuriakose, Maryam Khan, Eric K Chin, David R P Almeida
BACKGROUND AND OBJECTIVE: To assess the effect on best-corrected visual acuity (BCVA) and efficacy of the intravitreal sustained-release 0.7 mg dexamethasone implant (Ozurdex; Allergan, Irvine, CA) in patients with recalcitrant diabetic macular edema (DME). PATIENTS AND METHODS: Meta-analysis utilizing the MOOSE framework and a random effects model. Studies included adults undergoing treatment with Ozurdex for DME. The methodologic quality of each study was assessed using the MINORS and the Cochrane Collaboration Risk of Bias for randomized studies...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28195613/functional-and-morphological-evaluation-of-traumatized-eyes-with-berlin-s-edema-affecting-the-macula-using-mferg-microperimetry-and-sd-oct
#12
Joseph Daniel Boss, Joaquin Tosi, Inna Glybina, Asheesh Tewari, Gary W Abrams
BACKGROUND AND OBJECTIVE: To describe the structural and functional changes that occur in traumatic Berlin's edema involving the macula through assessment with multifocal electroretinogram (mfERG), microperimetry, fundus photography, and spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Retrospective case series of five eyes from four patients with macular traumatic Berlin's edema. Patients underwent baseline mfERG (three eyes), MP1 microperimetry (three eyes), fundus photography (five eyes), and SD-OCT (five eyes)...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28187882/an-anomaly-detection-approach-for-the-identification-of-dme-patients-using-spectral-domain-optical-coherence-tomography-images
#13
Désiré Sidibé, Shrinivasan Sankar, Guillaume Lemaître, Mojdeh Rastgoo, Joan Massich, Carol Y Cheung, Gavin S W Tan, Dan Milea, Ecosse Lamoureux, Tien Y Wong, Fabrice Mériaudeau
This paper proposes a method for automatic classification of spectral domain OCT data for the identification of patients with retinal diseases such as Diabetic Macular Edema (DME). We address this issue as an anomaly detection problem and propose a method that not only allows the classification of the OCT volume, but also allows the identification of the individual diseased B-scans inside the volume. Our approach is based on modeling the appearance of normal OCT images with a Gaussian Mixture Model (GMM) and detecting abnormal OCT images as outliers...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28185180/primary-iris-claw-iol-retrofixation-with-intravitreal-triamcinolone-acetonide-in-cases-of-inadequate-capsular-support
#14
Aditya Kelkar, Rachana Shah, Viraj Vasavda, Jai Kelkar, Shreekant Kelkar
PURPOSE: To assess the outcomes and analyze complication rates following primary iris claw IOL retrofixation with intravitreal triamcinolone acetonide. METHODS: This is a retrospective interventional case series. Patients with poor capsular support-diagnosed preoperatively or owing to intraoperative complications-were treated with iris claw IOL retrofixation with intravitreal triamcinolone acetonide. The data were retrospectively analyzed. RESULTS: 104 eyes of 102 patients with poor capsular support who underwent the procedure between 2010 and 2013 were analyzed...
February 9, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28182169/comparison-of-efficacy-and-side-effects-of-multispot-lasers-and-conventional-lasers-for-diabetic-retinopathy-treatment
#15
REVIEW
Hande Çeliker, Azer Erdağı Bulut, Özlem Şahin
Panretinal photocoagulation (PRP) is a standard treatment for proliferative diabetic retinopathy. Conventional laser (CL) therapy is performed in one or more sessions in single spot mode. Visual disabilities have been reported after treatment with CL, including central vision loss due to macular edema and peripheral visual field loss resulting from extensive inner retinal scarring. Multispot laser (MSL) photocoagulation has recently been introduced to clinical practice. Studies comparing PRP conducted with MSL and CL have reported that MSLs resulted in less retinal tissue damage and pain, and greater patient comfort compared to CL...
January 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28180033/platform-independent-cirrus-and-spectralis-thickness-measurements-in-eyes-with-diabetic-macular-edema-using-fully-automated-software
#16
Alex S Willoughby, Stephanie J Chiu, Rachel K Silverman, Sina Farsiu, Clare Bailey, Henry E Wiley, Frederick L Ferris, Glenn J Jaffe
PURPOSE: We determine whether the automated segmentation software, Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can measure, in a platform-independent manner, retinal thickness on Cirrus and Spectralis spectral domain optical coherence tomography (SD-OCT) images in eyes with diabetic macular edema (DME) under treatment in a clinical trial. METHODS: Automatic segmentation software was used to segment the internal limiting membrane (ILM), inner retinal pigment epithelium (RPE), and Bruch's membrane (BM) in SD-OCT images acquired by Cirrus and Spectralis commercial systems, from the same eye, on the same day during a clinical interventional DME trial...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28178701/a-nonrandomized-open-label-multicenter-phase-4-pilot-study-on-the-effect-and-safety-of-iluvien%C3%A2-in-chronic-diabetic-macular-edema-patients-considered-insufficiently-responsive-to-available-therapies-respond
#17
João Figueira, José Henriques, Miguel Amaro, Vítor Rosas, Dalila Alves, José Cunha-Vaz
PURPOSE: The aim of this study was to assess the effectiveness and safety of ILUVIEN® in patients with chronic diabetic macular edema (DME) who were insufficiently responsive to prior therapies. METHODS: This is a prospective, nonrandomized, multicenter, open-label, phase 4 pilot study assessing the effectiveness and safety of ILUVIEN® involving 12 patients insufficiently responsive to available therapies. Assessments were performed at screening, baseline, week 1, and months 1, 3, 6, 9, and 12...
February 9, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28178068/features-of-the-macula-and-central-visual-field-and-fixation-pattern-in-patients-with-retinitis-pigmentosa
#18
Isil Sayman Muslubas, Murat Karacorlu, Serra Arf, Mumin Hocaoglu, Mehmet Giray Ersoz
PURPOSE: To evaluate macular features and fixation pattern in patients with retinitis pigmentosa (RP) compared with healthy controls, using spectral-domain optical coherence tomography and MP-1 microperimetry. METHODS: Eighty-one eyes of 81 patients with RP and 90 eyes of 90 healthy subjects were assessed. The central foveal thickness, subfoveal choroidal thickness, ellipsoid zone length, and the mean retinal sensitivities and fixation characteristics were evaluated by spectral-domain optical coherence tomography and MP-1 microperimetry...
February 7, 2017: Retina
https://www.readbyqxmd.com/read/28176171/comparison-of-efficacy-of-intravitreal-ranibizumab-between-non-vitrectomized-and-vitrectomized-eyes-with-diabetic-macular-edema
#19
Yen-Yi Chen, Pei-Ying Chen, Fang-Ting Chen, Yun-Ju Chen, Jia-Kang Wang
PURPOSE: To compare the efficacy of intravitreal ranibizumab between non-vitrectomized and vitrectomized eyes with diabetic macular edema (DME). STUDY DESIGN: A retrospective, nonrandomized, and comparative study. METHODS: From May 2013 to March 2016, 148 eyes of 148 patients with treatment-naïve center-involving DME were reviewed in one institution. Forty-six eyes underwent prior vitrectomy at least 3 months ago, and 102 eyes did not receive any vitrectomy...
February 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28171859/comparison-of-55%C3%A2-wide-field-spectral-domain-optical-coherence-tomography-and-conventional-30%C3%A2-optical-coherence-tomography-for-the-assessment-of-diabetic-macular-edema
#20
Marion R Munk, Joel Lincke, Helena Giannakaki-Zimmermann, Andreas Ebneter, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To compare conventional 30° spectral domain optical coherence tomography (SD-OCT) with 55° wide-field SD-OCT for the assessment of diabetic macular edema (DME). METHODS: This study included 50 DME patients. Both 55° and 30° SD-OCT was conducted. Two readers evaluated scans according to a standardized grading protocol. Intergrader agreement as well as agreement between 30° and 55° SD-OCT were assessed. RESULTS: Intergrader agreement (κ) was strong and ranged from 0...
February 8, 2017: Ophthalmologica. Journal International D'ophtalmologie
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