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Functional Movement Screen

Diarmuid Lester, Bronagh McGrane, Sarahjane Belton, Michael J Duncan, Fiona C Chambers, Wesley O'Brien
(1) Background: Research has shown that post-primary Irish youth are insufficiently active and fail to reach a level of proficiency across basic movement skills. The purpose of the current research was to gather cross-sectional baseline data on Irish adolescent youth, specifically the prevalence of movement skills and patterns, in order to generate an overall perspective of movement within the first three years (Junior Certificate level) of post-primary education. (2) Methods: Data were collected on adolescents (N = 181; mean age: 14...
October 2, 2017: Sports
Yasuhiko Kizuka, Naoyuki Taniguchi
Bisecting GlcNAc, a branch structure in N-glycan, has unique functions and is involved in several diseases including Alzheimer's disease (AD). In this review, we provide an overview of the biosynthesis of bisecting GlcNAc and its physiological and pathological functions, particularly in the nervous system where bisecting GlcNAc is most highly expressed. The biosynthetic enzyme of bisecting GlcNAc is N-acetylglucosaminyltransferase-III (GnT-III). Overexpression, knockdown, and knockout of GnT-III have so far revealed various functions of bisecting GlcNAc, which are mediated by regulating the functions of key carrier proteins...
June 16, 2018: Glycoconjugate Journal
Samuel Stuart, Rodrigo Vitorio, Rosie Morris, Douglas N Martini, Peter C Fino, Martina Mancini
An emerging body of literature has examined cortical activity during walking and balance tasks in older adults and in people with Parkinson's disease, specifically using functional near infrared spectroscopy (fNIRS) or electroencephalography (EEG). This review provides an overview of this developing area, and examines the disease-specific mechanisms underlying walking or balance deficits. Medline, PubMed, PsychInfo and Scopus databases were searched. Articles that described cortical activity during walking and balance tasks in older adults and in those with PD were screened by the reviewers...
July 2018: Maturitas
Fabiana Terra Cunha Belache, Cíntia Pereira de Souza, Jessica Fernandez, Julia Castro, Paula Dos Santos Ferreira, Elizana Rodrigues de Sousa Rosa, Nathalia Cristina Gimenez de Araújo, Felipe José Jandre Reis, Renato Santos de Almeida, Leandro Alberto Calazans Nogueira, Luís Cláudio Lemos Correia, Ney Meziat-Filho
INTRODUCTION: Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy is an intervention that deals with potentially modifiable multidimensional aspects of pain (eg, provocative cognitive, movement and lifestyle behaviours). There is evidence (from a single randomised, controlled trial) that cognitive functional therapy is better than combined manual therapy and motor control exercise...
June 11, 2018: Journal of Physiotherapy
Jae Ho Seo, Ekta Agarwal, Kelly G Bryant, M Cecilia Caino, Eui Tae Kim, Andrew V Kossenkov, Hsin-Yao Tang, Lucia R Languino, Dmitry I Gabrilovich, Andrew R Cohen, David W Speicher, Dario C Altieri
Syntaphilin (SNPH) inhibits the movement of mitochondria in tumor cells, preventing their accumulation at the cortical cytoskeleton and limiting the bioenergetics of cell motility and invasion. Although this may suppress metastasis, the regulation of the SNPH pathway is not well understood. Using a global proteomics screen, we show that SNPH associates with multiple regulators of ubiquitin-dependent responses and is ubiquitinated by the E3 ligase CHIP (or STUB1) on Lys111 and Lys153 in the microtubule-binding domain...
June 13, 2018: Cancer Research
Lucas N Alberca, María L Sbaraglini, Juan F Morales, Roque Dietrich, María D Ruiz, Agustina M Pino Martínez, Cristian G Miranda, Laura Fraccaroli, Catalina D Alba Soto, Carolina Carrillo, Pablo H Palestro, Alan Talevi
Chagas disease is a neglected tropical disease endemic to Latin America, though migratory movements have recently spread it to other regions. Here, we have applied a cascade virtual screening campaign combining ligand- and structure-based methods. In order to find novel inhibitors of putrescine uptake in Trypanosoma cruzi , an ensemble of linear ligand-based classifiers obtained by has been applied as initial screening filter, followed by docking into a homology model of the putrescine permease Tc PAT12. 1,000 individual linear classifiers were inferred from a balanced dataset...
2018: Frontiers in Cellular and Infection Microbiology
Christopher J Todd, Patrick P Hubner, Philipp Hubner, Michael C Schubert, Americo A Migliaccio
The vestibulo-ocular reflex (VOR) is the primary mechanism for stabilizing vision during rapid head movements. We have developed a training technique that typically increases the VOR response a minimum of 15% after 15 mins of training. This technique relies on subjects tracking a visual target that moves as a function of head motion, but at a different speed, so that the VOR is challenged to increase in order to stabilize the retinal image of the target. We have developed a portable device, StableEyes, which implements this technique so that unassisted training can be performed at home by patients with VOR hypofunction...
June 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Piyali Guhathakurta, Ewa Prochniewicz, Benjamin D Grant, Kurt C Peterson, David D Thomas
We have used a novel time-resolved fluorescence resonance energy transfer (TR-FRET) assay to detect small-molecule modulators of actin-myosin structure and function. Actin-myosin interactions play crucial roles in the generation of cellular force and movement. Numerous mutations and post-translational modifications of actin or myosin disrupt muscle function and cause life-threatening syndromes. Here we used a FRET biosensor to identify modulators that bind to the actin-myosin interface and alter the structural dynamics of this complex...
June 4, 2018: Journal of Biological Chemistry
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjsem-2018-000357.].
2018: BMJ Open Sport & Exercise Medicine
Peter M Nelson, Ethan R Van Norman, David C Parker
The current study examined reading skills at two distal time-points for 6828 students who received support from a tier II reading intervention program in the 2015 and 2016 school years. The first follow-up assessment occurred at the end of the year in which intervention was provided and the second assessment occurred at the beginning of the next year. Multilevel models were fit to the data to predict the log odds that a student would meet spring and fall reading benchmarks depending on a variety of student- and school-level predictors...
June 2018: Journal of School Psychology
Mahesh Kamate, Nishant Mittal, Deepa Metgud
BACKGROUND: Therapeutic options for management of choreoathetoid cerebral palsy, which is a permanent disorder, are very limited. Available medications either have significant side effects or are unsuitable for long-term use. Risperidone has shown promise in the management of chorea and has been found to be safe in children less than five years. METHODS: Children with choreoathetoid cerebral palsy were enrolled after parental consent and given risperidone for six-month period along with standard care...
April 20, 2018: Pediatric Neurology
Gabriella A Horvath, Yulin Zhao, Maja Tarailo-Graovac, Cyrus Boelman, Harinder Gill, Casper Shyr, James Lee, Ingrid Blydt-Hansen, Britt I Drögemöller, Jacqueline Moreland, Colin J Ross, Wyeth W Wasserman, Andrea Masotti, Paul A Slesinger, Clara D M van Karnebeek
Here, we describe a fourth case of a human with a de novo KCNJ6 (GIRK2) mutation, who presented with clinical findings of severe hyperkinetic movement disorder and developmental delay, similar to Keppen-Lubinsky syndrome but without lipodystrophy. Whole exome sequencing of the patient's DNA revealed a heterozygous de novo variant in the KCNJ6 (c.512T>G, p.Leu171Arg). We conducted in vitro functional studies to determine if this Leu-to-Arg mutation alters the function of GIRK2 channels. Heterologous expression of the mutant GIRK2 channel alone produced an aberrant basal inward current that lacked G protein activation, lost K+ selectivity and gained Ca2+ permeability...
May 28, 2018: Neuroscience
Hui Guang, Linhong Ji, Yingying Shi, Berno J E Misgeld
The robot-assisted therapy has been demonstrated to be effective in the improvements of limb function and even activities of daily living for patients after stroke. This paper presents an interactive upper-limb rehabilitation robot with a parallel mechanism and an isometric screen embedded in the platform to display trajectories. In the dynamic modeling for impedance control, the effects of friction and inertia are reduced by introducing the principle of virtual work and derivative of Jacobian matrix. To achieve the assist-as-needed impedance control for arbitrary trajectories, the strategy based on orthogonal deviations is proposed...
2018: Journal of Healthcare Engineering
Roisin Cahalan, Norma Bargary, Kieran O'Sullivan
Dance is an extremely popular activity among adolescents and has a range of associated physical and psychological health benefits. However, pain and injury in young elite dancers is pervasive, and the underlying risk factors are poorly understood. This study investigated the incidence of pain and injury in elite adolescent Irish dancers and examined a range of potentially associated biopsychosocial risk factors. Thirty-seven championship level Irish dancers completed baseline questionnaires recording any episode of pain or injury over the previous 12 months...
June 15, 2018: Journal of Dance Medicine & Science
Carlos E Mantese, Artur Schumacher-Schuh, Carlos R M Rieder
The treatment of Parkinson's disease (PD) with dopaminergic therapy improves functionality and quality of life. However, as the disease progresses, the wearing-off phenomenon develops, which necessitates complex posology adjustment or adjuvant therapy. This phenomenon may not be well recognized, especially if it is mild or involves nonmotor symptoms. Questionnaires were developed to improve the recognition of the wearing-off phenomenon. The questionnaires consist of a list of symptoms that patients must check if they have and if the symptoms improve with medication...
2018: Parkinson's Disease
J Wilke, D Niederer, L Vogt, W Banzer
OBJECTIVES: To investigate the practices and attitudes of professional basketball head coaches towards injury prevention. DESIGN: Survey. SETTING: Elite-level basketball. PARTICIPANTS: Head coaches of all 366 German professional teams. MAIN OUTCOME MEASURES: Use of injury risk screening methods, rated importance of different musculoskeletal injuries and rated effectiveness of preventive interventions...
April 17, 2018: Physical Therapy in Sport
Fraser Philp, Dimitra Blana, Edward K Chadwick, Caroline Stewart, Claire Stapleton, Kim Major, Anand D Pandyan
Objective: The aim of the study was to evaluate the reported measurement capabilities and predictive validity of the Functional Movement Screen (FMS) for injury. Methods: This was a prospective observational longitudinal study of 24 male footballers from a single team in England, alongside analysis of an existing database over one season (September 2015-May 2016). A preseason FMS was carried out with scores recorded by an experienced assessor and derived, retrospectively, from the three-dimensional movement data that were simultaneously captured...
2018: BMJ Open Sport & Exercise Medicine
Teppei Ebina, Yoshito Masamizu, Yasuhiro R Tanaka, Akiya Watakabe, Reiko Hirakawa, Yuka Hirayama, Riichiro Hira, Shin-Ichiro Terada, Daisuke Koketsu, Kazuo Hikosaka, Hiroaki Mizukami, Atsushi Nambu, Erika Sasaki, Tetsuo Yamamori, Masanori Matsuzaki
Two-photon imaging in behaving animals has revealed neuronal activities related to behavioral and cognitive function at single-cell resolution. However, marmosets have posed a challenge due to limited success in training on motor tasks. Here we report the development of protocols to train head-fixed common marmosets to perform upper-limb movement tasks and simultaneously perform two-photon imaging. After 2-5 months of training sessions, head-fixed marmosets can control a manipulandum to move a cursor to a target on a screen...
May 14, 2018: Nature Communications
Yuqin Zang, Mengting Dong, Kai Zhang, Wenyan Tian, Yingmei Wang, Fengxia Xue
Endometrial carcinoma (EC) is one of the most common gynecological malignancies. The malignant degree increases between grade (G)1 and G3, and EC of G3 usually presents a high recurrence rate and poor prognosis. Therefore, the present study aimed to examine the principal genes associated with the degree of differentiation in EC. The microarrays GSE17025, GSE24537 and GSE35784, representing data of Type I EC samples of G1 and G3, were downloaded from the Gene Expression Omnibus. The differentially expressed genes (DEGs) and differentially expressed micro (mi)RNAs (DEMs) were identified, followed by functional enrichment analyses and interaction network construction...
May 4, 2018: Molecular Medicine Reports
Julia Bidonde, Catherine Boden, Soo Kim, Angela J Busch, Suelen M Goes, Emily Knight
BACKGROUND: Fibromyalgia is a chronic disorder characterized by widespread muscular tenderness, pain, fatigue, and cognitive difficulties. Nonpharmacological treatment options, such as physical activity, are important for people with fibromyalgia. There are strong recommendations to support engagement in physical activity for symptom management among adults with fibromyalgia. Dance is a mode of physical activity that may allow individuals with fibromyalgia to improve their physical function, health, and well-being...
May 10, 2018: JMIR Rehabilitation and Assistive Technologies
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