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Functional fitness

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https://www.readbyqxmd.com/read/29793191/development-and-validation-of-a-prediction-model-for-functional-decline-in-older-medical-inpatients
#1
Toshihiko Takada, Shingo Fukuma, Yosuke Yamamoto, Yukio Tsugihashi, Hiroyuki Nagano, Michio Hayashi, Jun Miyashita, Teruhisa Azuma, Shunichi Fukuhara
OBJECTIVE: To prevent functional decline in older inpatients, identification of high-risk patients is crucial. The aim of this study was to develop and validate a prediction model to assess the risk of functional decline in older medical inpatients. METHODS: In this retrospective cohort study, patients ≥65 years admitted acutely to medical wards were included. The healthcare database of 246 acute care hospitals (n = 229,913) was used for derivation, and two acute care hospitals (n = 1767 and 5443, respectively) were used for validation...
May 17, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29793002/rasch-analysis-suggested-that-items-from-the-template-for-intervention-description-and-replication-tidier-checklist-can-be-summed-to-create-a-score
#2
Tie P Yamato, Chris G Maher, Bruno T Saragiotto, Mark J Catley, Anne M Moseley
OBJECTIVE: The aim of this study was to construct and evaluate a summary score of reporting completeness based on the Template for Intervention Description and Replication (TIDieR). STUDY DESIGN AND SETTING: We included 200 reports published in 2013 randomly selected from the Physiotherapy Evidence Database (PEDro). We summed the scores for the 12 items for the intervention and control groups for each trial in order to create a summary score from 0 to 24. Rasch analysis was used to investigate the item hierarchy, category function and reliability of the TIDieR checklist and determine the extent to which the summary score can be considered an interval-level measure...
May 21, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29792826/fast-evolving-human-specific-neural-enhancers-are-associated-with-aging-related-diseases
#3
Han Chen, Chunyan Li, Zhicheng Zhou, Han Liang
The antagonistic pleiotropy theory hypothesizes that evolutionary adaptations maximizing the fitness in early age increase disease burden after reproduction. This theory remains largely untested at the molecular level. Here, we analyzed enhancer evolution in primates to investigate the relationships between aging-related diseases and enhancers acquired after the human-chimpanzee divergence. We report a 5-fold increased evolutionary rate of enhancers that are activated in neural tissues, leading to fixation of ∼100 human-specific enhancers potentially under adaptation...
May 23, 2018: Cell Systems
https://www.readbyqxmd.com/read/29792818/substrate-induced-formation-of-ribosomal-decoding-center-for-accurate-and-rapid-genetic-code-translation
#4
Michael Y Pavlov, Måns Ehrenberg
Accurate translation of genetic information is crucial for synthesis of functional proteins in all organisms. We use recent experimental data to discuss how induced fit affects accuracy of initial codon selection on the ribosome by aminoacyl transfer RNA in ternary complex ( T3 ) with elongation factor Tu (EF-Tu) and guanosine-5'-triphosphate (GTP). We define actual accuracy ([Formula: see text]) of a particular protein synthesis system as its current accuracy and the effective selectivity ([Formula: see text]) as [Formula: see text] in the limit of zero ribosomal binding affinity for T3 ...
May 20, 2018: Annual Review of Biophysics
https://www.readbyqxmd.com/read/29792817/macroscopic-theory-for-evolving-biological-systems-akin-to-thermodynamics
#5
Kunihiko Kaneko, Chikara Furusawa
We present a macroscopic theory to characterize the plasticity, robustness, and evolvability of biological responses and their fluctuations. First, linear approximation in intracellular reaction dynamics is used to demonstrate proportional changes in the expression of all cellular components in response to a given environmental stress, with the proportion coefficient determined by the change in growth rate as a consequence of the steady growth of cells. We further demonstrate that this relationship is supported through adaptation experiments of bacteria, perhaps too well as this proportionality is held even across cultures of different types of conditions...
May 20, 2018: Annual Review of Biophysics
https://www.readbyqxmd.com/read/29792361/effect-of-blueberry-extract-carriers-and-combinations-on-the-growth-rate-of-probiotic-and-pathogenic-bacteria
#6
María Gretel Michel-Barba, Hugo Espinosa-Andrews, Rudy Antonio García-Reyes, Yves Desjardins, Marisela González-Ávila
The blueberry is recognised as a source of phenolic compounds that have beneficial effects on human health; however, they possess low bioavailability and can be degraded by gastrointestinal conditions. Encapsulation has been widely used to mitigate these disadvantages; Gum Arabic (GA) and Corn Syrup Solids (CSS) are common carriers used in this technique. The aim of this study was to evaluate the effect of Blueberry Extract (BE), carriers and their mixtures on the kinetic growth and maximal growth rate of probiotics and pathogenic bacteria...
May 24, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29792195/histamine-activates-inflammatory-response-and-depresses-casein-synthesis-in-mammary-gland-of-dairy-cows-during-sara
#7
Guangjun Chang, Lailai Wang, Nana Ma, Wenwen Zhang, Huanmin Zhang, Hongyu Dai, Xiangzhen Shen
BACKGROUND: Mounting evidences observed that subacute ruminal acidosis (SARA) induced by high concentration (HC) diet increases the translocation of histamine from digestive tract into circulation causing a diverse of diseases in dairy cows. However, it is largely unknown how it does affect the function of mammary gland and milk quality. Hence, this study aims to observe the effects of histamine derived from the digestive tract on the inflammatory response and casein synthesis in the mammary glands during SARA...
May 23, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29792159/on-the-possibility-of-death-of-new-genes-evidence-from-the-deletion-of-de-novo-micrornas
#8
Guang-An Lu, Yixin Zhao, Zhongqi Liufu, Chung-I Wu
BACKGROUND: New genes are constantly formed, sometimes from non-genic sequences, creating what is referred to as de novo genes. Since the total number of genes remains relatively steady, gene deaths likely balance out new births. In metazoan genomes, microRNAs (miRs) genes, small and non-coding, account for the bulk of functional de novo genes and are particularly suited to the investigation of gene death. RESULTS: In this study, we discover a Drosophila-specific de novo miRNA (mir-977) that may be facing impending death...
May 23, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29792030/on-the-role-of-counterions-in-molecularly-imprinted-polymers-for-anionic-species
#9
Sabine Wagner, Carlos Zapata, Wei Wan, Kornelia Gawlitza, Marcus Weber, Knut Rurack
Small-molecule oxoanions are often imprinted noncovalently as carboxylates into molecularly imprinted polymers (MIPs), requiring the use of an organic counterion. Popular species are either pentamethylpiperidine (PMP) as a protonatable cation or tetraalkylammonium (TXA) ions as permanent cations. The present work explores the influence of the TXA as a function of their alkyl chain length, from methyl to octyl, using UV/vis absorption, fluorescence titrations and HPLC, as well as MD simulations. Protected phenylalanines (Z-L/D-Phe) served as templates/analytes...
May 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29791756/interactions-between-insulin-and-diet-on-striatal-dopamine-uptake-kinetics-in-rodent-brain-slices
#10
Jyoti C Patel, Melissa A Stouffer, Maria Mancini, Charles Nicholson, Kenneth D Carr, Margaret E Rice
Diet influences dopamine transmission in motor- and reward-related basal ganglia circuitry. In part, this reflects diet-dependent regulation of circulating and brain insulin levels. Activation of striatal insulin receptors amplifies axonal dopamine release in brain slices, and regulates food preference in vivo. The effect of insulin on dopamine release is indirect, and requires striatal cholinergic interneurons that express insulin receptors. However, insulin also increases dopamine uptake by promoting dopamine transporter (DAT) surface expression, which counteracts enhanced dopamine release...
May 23, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29791031/ocean-acidification-stimulates-particulate-organic-carbon-accumulation-in-two-antarctic-diatom-species-under-moderate-and-high-natural-solar-radiation
#11
Jasmin P Heiden, Silke Thoms, Kai Bischof, Scarlett Trimborn
Impacts of rising atmospheric CO2 concentrations and increased daily irradiances from enhanced surface water stratification on phytoplankton physiology in the coastal Southern Ocean remain still unclear. Therefore, in the two Antarctic diatoms Fragilariopsis curta and Odontella weissflogii the effects of moderate and high natural solar radiation combined with either ambient or future pCO2 on cellular particulate organic carbon (POC) contents and photophysiology were investigated. Results showed that increasing CO2 concentrations had greater impacts on diatom physiology than exposure to increasing solar radiation...
May 23, 2018: Journal of Phycology
https://www.readbyqxmd.com/read/29790670/reference-equations-for-the-interpretation-of-forced-expiratory-and-plethysmographic-measurements-in-infants
#12
Zihang Lu, Rachel E Foong, Krzysztof Kowalik, Theo J Moraes, Aimee Dubeau, Diana Lefebvre, Stephanie D Davis, Susan Balkovec, Allan Becker, Piush Mandhane, Stuart E Turvey, Wendy Lou, Malcolm R Sears, Felix Ratjen, Padmaja Subbarao
BACKGROUND: Pulmonary function testing is commonly performed for diagnosis and clinical management of respiratory diseases. It is important to use appropriate reference equations from healthy subjects for interpretation of data from infants with lung disease. This study aimed to determine if published reference equations were similar to forced flow measures and plethysmographic infant pulmonary function testing data collected in the Canadian Healthy Infant Longitudinal Development (CHILD) Study...
May 23, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29790397/higher-cartilage-wear-in-unipolar-than-bipolar-hemiarthroplasties-of-the-hip-at-2-years-a-randomized-controlled-radiostereometric-study-in-19-fit-elderly-patients-with-femoral-neck-fractures
#13
Wender Figved, Stian Svenøy, Stephan M Röhrl, Jon Dahl, Lars Nordsletten, Frede Frihagen
Background and purpose - The use of unipolar hemi-arthroplasties for femoral neck fractures is increasing in some countries due to reports of higher reoperation rates in bipolar prostheses. On the other hand, it has been proposed that bipolar hemiarthroplasties have clinical advantages and less cartilage wear than unipolar hemiarthroplasties. We compared cartilage wear between bipolar and unipolar hemiarthroplasties using radiostereometric analyses (RSA), in patients aged 70 years or older. Patients and methods - 28 ambulatory, lucid patients were randomized to treatment with a unipolar or a bipolar hemiarthroplasty for an acute femoral neck fracture...
May 23, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29790074/attentional-modulation-of-desensitization-to-odor
#14
Nicholas Fallon, Timo Giesbrecht, Andrej Stancak
Subjective and behavioral responsiveness to odor diminishes during prolonged exposure. The precise mechanisms underlying olfactory desensitization are not fully understood, but previous studies indicate that the phenomenon may be modulated by central-cognitive processes. The present study investigated the effect of attention on perceived intensity during exposure to a pleasant odor. A within-subjects design was utilized with 19 participants attending 2 sessions. During each session, participants continuously rated their perceived intensity of a 10-minute exposure to a pleasant fragrance administered using an olfactometer...
May 22, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29790045/basic-red-2-and-methyl-violet-adsorption-by-date-pits-adsorbent-characterization-optimization-by-rsm-and-ccd-equilibrium-and-kinetic-studies
#15
Manel Wakkel, Besma Khiari, Féthi Zagrouba
The potential of raw date pits as a natural, widely available and low-cost agricultural waste has been studied in order to adsorb cationic dyes from an aqueous solution. Date pits were characterized by FTIR, SEM, BET, and XRD analysis. To optimize removal of two industrial dyes, basic red 2 (BR2) and methyl violet (MV), from aqueous solution using date pits, response surface methodology (RSM) is employed. Tests were carried out as per central composite design (CCD) with four input parameters namely contact time, temperature, initial concentration of adsorbate, and pH...
May 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29789761/visual-outcome-after-posterior-uveal-melanoma-episcleral-brachytherapy-including-radiobiological-doses
#16
David Miguel, Jesús María de Frutos-Baraja, Francisco López-Lara, María Antonia Saornil, Ciro García-Alvarez, Pilar Alonso, Patricia Diezhandino
Purpose: To assess the long-term influence of radiobiological doses in the evolution of visual acuity (VA) in patients with uveal melanoma treated by episcleral brachytherapy. Material and methods: Visual acuity was evaluated prospectively from a case series of 243 patients in 2016 treated with 125 I. Data analysis was applied to trend VA outcome and find the accurate best-fit line. Biologically effective dose (BED) was included in survival analysis with the use of Kaplan-Meier and Cox regressions...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789712/distribution-and-determinants-of-retinol-in-norwegian-adolescents-and-its-relation-to-bone-mineral-density-the-troms%C3%A3-study-fit-futures
#17
M S W Teigmo, T E Gundersen, N Emaus, G Grimnes
BACKGROUND/OBJECTIVES: Sufficient vitamin A levels are important for many functions-and both too little and too much may have detrimental health effects. The aim of the study was to describe the distribution of retinol levels in Norwegian adolescents, the relation between lifestyle factors and retinol levels, and the relation between retinol levels and bone mineral density (BMD). SUBJECTS/METHODS: Serum retinol was measured in 414 girls and 474 boys aged 15-19 years, participating in the Tromsø Study: Fit Futures...
May 23, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29789570/structural-resolution-of-inorganic-nanotubes-with-complex-stoichiometry
#18
Geoffrey Monet, Mohamed S Amara, Stéphan Rouzière, Erwan Paineau, Ziwei Chai, Joshua D Elliott, Emiliano Poli, Li-Min Liu, Gilberto Teobaldi, Pascale Launois
Determination of the atomic structure of inorganic single-walled nanotubes with complex stoichiometry remains elusive due to the too many atomic coordinates to be fitted with respect to X-ray diffractograms inherently exhibiting rather broad features. Here we introduce a methodology to reduce the number of fitted variables and enable resolution of the atomic structure for inorganic nanotubes with complex stoichiometry. We apply it to recently synthesized methylated aluminosilicate and aluminogermanate imogolite nanotubes of nominal composition (OH)3 Al2 O3 Si(Ge)CH3 ...
May 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29789563/analysis-of-moisture-content-in-beetroot-using-fourier-transform-infrared-spectroscopy-and-by-principal-component-analysis
#19
Noel Nesakumar, Chanthini Baskar, Srinivasan Kesavan, John Bosco Balaguru Rayappan, Subbiah Alwarappan
The moisture content of beetroot varies during long-term cold storage. In this work, we propose a strategy to identify the moisture content and age of beetroot using principal component analysis coupled Fourier transform infrared spectroscopy (FTIR). Frequent FTIR measurements were recorded directly from the beetroot sample surface over a period of 34 days for analysing its moisture content employing attenuated total reflectance in the spectral ranges of 2614-4000 and 1465-1853 cm-1 with a spectral resolution of 8 cm-1 ...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789359/conserved-responses-in-a-war-of-small-molecules-between-a-plant-pathogenic-bacterium-and-fungi
#20
Joseph E Spraker, Philipp Wiemann, Joshua A Baccile, Nandhitha Venkatesh, Julia Schumacher, Frank C Schroeder, Laura M Sanchez, Nancy P Keller
Small-molecule signaling is one major mode of communication within the polymicrobial consortium of soil and rhizosphere. While microbial secondary metabolite (SM) production and responses of individual species have been studied extensively, little is known about potentially conserved roles of SM signals in multilayered symbiotic or antagonistic relationships. Here, we characterize the SM-mediated interaction between the plant-pathogenic bacterium Ralstonia solanacearum and the two plant-pathogenic fungi Fusarium fujikuroi and Botrytis cinerea We show that cellular differentiation and SM biosynthesis in F...
May 22, 2018: MBio
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