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https://www.readbyqxmd.com/read/28433942/synthesis-and-characterization-of-poly-propylene-imine-dendrimer-grafted-gold-nanoparticles-as-nanocarriers-of-doxorubicin
#1
Marzieh Golshan, Mehdi Salami-Kalajahi, Mina Mirshekarpour, Hossein Roghani-Mamaqani, Maryam Mohammadi
The aim of current work is synthesis 4th-generation-poly(propylene imine) (PPI)-dendrimer modified gold nanoparticles (Au-G4A) as nanocarriers for doxorubicin (DOX) and studying in vitro drug release kinetics from nanocarriers into different media. Accordingly, AuNPs were synthesized by reduction of chloroauric acid (HAuCl4) aqueous solution with trisodium citrate and modified with cysteamine to obtain amine-functionalized (Au-NH2) nanoparticles. Au-NH2 nanoparticles were used as multifunctional cores and participated in Michael addition of acrylonitrile and reduction process by lithium aluminum hydride (LAH) to synthesize Au-G4A nanoparticles...
April 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28433932/the-unseen-rhizosphere-root-soil-microbe-interactions-for-crop-production
#2
REVIEW
Ruifu Zhang, Jorge M Vivanco, Qirong Shen
The underground root-soil-microbe interactions are extremely complex, but vitally important for aboveground plant growth, health and fitness. The pressure to reduce our reliance on agrochemicals, and sustainable efforts to develop agriculture makes rhizosphere interactions' research a hotspot. Recent advances provide new insights about the signals, pathways, functions and mechanisms of these interactions. In this review, we provide an overview about recent progress in rhizosphere interaction networks in crops...
April 20, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28433680/organocatalyzed-and-mechanochemical-solvent-free-synthesis-of-novel-and-functionalized-bis-biphenyl-substituted-thiazolidinones-as-potent-tyrosinase-inhibitors-sar-and-molecular-modeling-studies
#3
Sadaf Mutahir, Muhammad Asim Khan, Islam Ullah Khan, Muhammad Yar, Muhammad Ashraf, Sidra Tariq, Ren-Long Ye, Bao-Jing Zhou
Eluding the involvement of solvents in organic synthesis and introducing environment friendly procedures can control environmental problems. A facile and an efficient solvent free mechanochemical method (grinding) is achieved to synthesize novel bis-biphenyl substituted thiazolidinones using non-toxic and cheap N-acetyl glycine (NAG). Organocatalytic condensation of a series of Schiff's bases bearing different substituents with thioglycolic acid produces a variety of thiazolidinones derivatives in good to excellent yield...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28433372/intrinsic-fertility-of-human-oocytes
#4
Sherman J Silber, Keiichi Kato, Naoki Aoyama, Akiko Yabuuchi, Helen Skaletsky, Yuting Fan, Kazunori Shinohara, Noriyuki Yatabe, Tamotsu Kobayashi
OBJECTIVE: To study the intrinsic fertility of the human oocyte. DESIGN: A large retrospective study of natural cycle single embryo transfer (ET) IVF cycles. SETTING: Private IVF clinic, university, and private hospital. PATIENT(S): Patients were enrolled consecutively over an 8-year period in a single ET natural cycle protocol. INTERVENTION(S): A total of 13,949 oocyte retrievals with natural IVF single ET...
April 19, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28433177/kinetic-study-of-thermal-degradation-of-chitosan-as-a-function-of-deacetylation-degree
#5
M A Gámiz-González, D M Correia, S Lanceros-Mendez, V Sencadas, J L Gómez Ribelles, A Vidaurre
Thermal degradation of chitosan with varying deacetylation degree (DD) ranging between 50 and 85% was analyzed by dynamic thermogravimetric analysis at different heating rates. The present study focused on the temperature range between 500 and 800K, above water evaporation. Thermal degradation showed a main degradation stage in this temperature interval with a second stage that appeared in the weight derivative curves as a shoulder in the high temperature side of the main peak with increasing intensity as the DD decreased...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433167/ammonium-pillared-montmorillonite-cofe2o4-composite-caged-in-calcium-alginate-beads-for-the-removal-of-cs-from-wastewater
#6
Xian-Ming Zheng, Jun-Feng Dou, Meng Xia, Ai-Zhong Ding
Novel and magnetic adsorbent ammonium-pillared montmorillonite-CoFe2O4 composite caged in calcium alginate beads was prepared by using non-toxic raw materials. The morphology, magnetic properties, functional groups, and crystal structure of the compound were characterized by SEM, VSM, FT-IR and XRD. The adsorption behaviors were also investigated via adsorption experiments and response surface methodology was used to optimize the operation conditions. The beads showed high selectivity for Cs(+) in the presence of Na(+) and could be rapidly separated from the mixed solution under an external magnetic field...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433033/model-for-the-alpha-and-beta-shear-mechanical-properties-of-supercooled-liquids-and-its-comparison-to-squalane-data
#7
Tina Hecksher, Niels Boye Olsen, Jeppe C Dyre
This paper presents data for supercooled squalane's frequency-dependent shear modulus covering frequencies from 10 mHz to 30 kHz and temperatures from 168 K to 190 K; measurements are also reported for the glass phase down to 146 K. The data reveal a strong mechanical beta process. A model is proposed for the shear response of the metastable equilibrium liquid phase of supercooled liquids. The model is an electrical equivalent-circuit characterized by additivity of the dynamic shear compliances of the alpha and beta processes...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28433007/alternative-definition-of-excitation-amplitudes-in-multi-reference-state-specific-coupled-cluster
#8
Yann Garniron, Emmanuel Giner, Jean-Paul Malrieu, Anthony Scemama
A central difficulty of state-specific Multi-Reference Coupled Cluster (MR-CC) in the multi-exponential Jeziorski-Monkhorst formalism concerns the definition of the amplitudes of the single and double excitation operators appearing in the exponential wave operators. If the reference space is a complete active space (CAS), the number of these amplitudes is larger than the number of singly and doubly excited determinants on which one may project the eigenequation, and one must impose additional conditions. The present work first defines a state-specific reference-independent operator T∼^(m) which acting on the CAS component of the wave function |Ψ0(m)⟩ maximizes the overlap between (1+T∼^(m))|Ψ0(m)⟩ and the eigenvector of the CAS-SD (Singles and Doubles) Configuration Interaction (CI) matrix |ΨCAS-SD(m)⟩...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28431251/tunable-expression-tools-enable-single-cell-strain-distinction-in-the-gut-microbiome
#9
Weston R Whitaker, Elizabeth Stanley Shepherd, Justin L Sonnenburg
Applying synthetic biology to engineer gut-resident microbes provides new avenues to investigate microbe-host interactions, perform diagnostics, and deliver therapeutics. Here, we describe a platform for engineering Bacteroides, the most abundant genus in the Western microbiota, which includes a process for high-throughput strain modification. We have identified a novel phage promoter and translational tuning strategy and achieved an unprecedented level of expression that enables imaging of fluorescent-protein-expressing Bacteroides stably colonizing the mouse gut...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431011/the-relationship-between-pain-characteristics-peer-difficulties-and-emotional-functioning-among-adolescents-seeking-treatment-for-chronic-pain-a-test-of-mediational-models
#10
Sherilynn F Chan, Mark Connelly, Dustin P Wallace
To evaluate patterns of relationships between pain characteristics, peer difficulties, and emotional functioning in a sample of adolescents seeking treatment for chronic pain. Participants were 172 adolescents (age M  = 14.88 years; 76% female, 88% White) with heterogeneous chronic pain disorders who completed measures of pain characteristics, peer difficulties, and emotional functioning before their new patient appointment in a pain management clinic. Direct and indirect relationships between variables were tested using path analysis...
April 19, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28430980/the-relationship-between-symptom-relief-and-psychosocial-functional-improvement-during-acute-electroconvulsive-therapy-for-patients-with-major-depressive-disorder
#11
Ching-Hua Lin, Wei-Cheng Yang
Background: We aimed to compare the degree of symptom relief to psychosocial functional (abbreviated as "functional") improvement and explore the relationships between symptom relief and functional improvement during acute electroconvulsive therapy (ECT) for patients with major depressive disorder (MDD). Methods: MDD inpatients (N=130) requiring ECT were recruited. ECT was generally performed for a maximum of 12 treatments. Symptom severity, using the 17-item Hamilton Depression Rating Scale (HAMD-17), and psychosocial functioning (abbreviated as "functioning"), using the Modified Work and Social Adjustment Scale (MWSAS), were assessed before ECT, after every 3 ECT treatments, and after the final ECT...
April 18, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28430546/overall-preference-of-running-shoes-can-be-predicted-by-suitable-perception-factors-using-a-multiple-regression-model
#12
Cheryl Sihui Tay, Thorsten Sterzing, Chen Yen Lim, Rui Ding, Pui Wah Kong
OBJECTIVE: This study examined (a) the strength of four individual footwear perception factors to influence the overall preference of running shoes and (b) whether these perception factors satisfied the nonmulticollinear assumption in a regression model. BACKGROUND: Running footwear must fulfill multiple functional criteria to satisfy its potential users. Footwear perception factors, such as fit and cushioning, are commonly used to guide shoe design and development, but it is unclear whether running-footwear users are able to differentiate one factor from another...
May 2017: Human Factors
https://www.readbyqxmd.com/read/28430270/atomistic-non-adiabatic-dynamics-of-the-lh2-complex-with-a-gpu-accelerated-ab-initio-exciton-model
#13
Aaron Sisto, Clem Stross, Marc W van der Kamp, Michael O'Connor, Simon McIntosh-Smith, Graham T Johnson, Edward G Hohenstein, Fred R Manby, David R Glowacki, Todd J Martinez
We recently outlined an efficient multi-tiered parallel ab initio excitonic framework that utilizes time dependent density functional theory (TDDFT) to calculate ground and excited state energies and gradients of large supramolecular complexes in atomistic detail - enabling us to undertake non-adiabatic simulations which explicitly account for the coupled anharmonic vibrational motion of all the constituent atoms in a supramolecular system. Here we apply that framework to the 27 coupled bacterio-chlorophyll-a chromophores which make up the LH2 complex, using it to compute an on-the-fly nonadiabatic surface-hopping (SH) trajectory of electronically excited LH2...
April 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28430239/research-on-intelligent-algorithms-for-amplitude-optimization-of-wavefront-shaping
#14
Qi Feng, Bin Zhang, Zhipeng Liu, Chengyou Lin, Yingchun Ding
This paper demonstrates further research on intelligent algorithms of binary amplitude optimization for wavefront shaping by numerical simulations. A better fitness function of the genetic algorithm (GA) has been presented after a comparative analysis of enhancement. With this new discriminant, we have achieved a relative enhancement of 0.225, which is higher than the theoretical value (0.159). In addition, we have also proposed a kind of modified particle swarm optimization algorithm (PSO), which has a higher enhancement than the unmodified PSO and a faster convergence speed than the GA...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28430105/switching-of-metabolic-programs-in-response-to-light-availability-is-an-essential-function-of-the-cyanobacterial-circadian-output-pathway
#15
Anna M Puszynska, Erin K O'Shea
The transcription factor RpaA is the master regulator of circadian transcription in cyanobacteria, driving genome-wide oscillations in mRNA abundance. Deletion of rpaA has no effect on viability in constant light conditions, but renders cells inviable in cycling conditions when light and dark periods alternate. We investigated the mechanisms underlying this viability defect, and demonstrate that the rpaA(-) strain cannot maintain appropriate energy status at night, does not accumulate carbon reserves during the day, and is defective in transcription of genes crucial for utilization of carbohydrate stores at night...
April 21, 2017: ELife
https://www.readbyqxmd.com/read/28429939/solute-rotation-in-ionic-liquids-size-shape-and-electrostatic-effects
#16
Christopher A Rumble, Caleb Uitvlugt, Brian Conway, Mark Maroncelli
Herein are reported temperature-dependent measurements and molecular dynamics simulations designed to investigate the effects of molecular size, shape, and electrostatics on rotational dynamics in ionic liquids. Experiments were performed in the representative ionic liquid 1-butyl-3-methylimadazolium tetrafluoroborate ([Im41][BF4]) and simulations in the generic ionic liquid model ILM2 as well as a more detailed representation of [Im41][BF4]. 2H longitudinal spin relaxation times were measured for deuterated versions of 1,4-dimethylbenzene, 1-cyano-4-methylbenzene, and 1,4-dimethylpyridinium between 296-337 K...
April 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28429418/the-dynamics-of-the-reaction-of-feo-and-h2-a-model-for-inorganic-oxidation
#17
Stéphanie Essafi, David P Tew, Jeremy N Harvey
Extensive density functional theory (DFT) calculations using the B3LYP functional were used to explore the sextet and quartet energy potential energy surfaces (PESs) of the title reaction, and as a basis to fit global analytical reactive PESs. Surface-hopping dynamics on these PESs reproduce the experimentally observed reactivity and confirm that hydrogen activation rather than spin-state change is rate-limiting at low reaction energy, where the main products are Fe(+) and H2 O. A change in spin state is inefficient in the product region so that excited-state (4) Fe(+) is the dominant product...
April 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28428879/a-systems-biology-approach-to-investigating-the-influence-of-exercise-and-fitness-on-the-composition-of-leukocytes-in-peripheral-blood
#18
Michael P Gustafson, Ara Celi DiCostanzo, Courtney M Wheatley, Chul-Ho Kim, Svetlana Bornschlegl, Dennis A Gastineau, Bruce D Johnson, Allan B Dietz
BACKGROUND: Exercise immunology has become a growing field in the past 20 years, with an emphasis on understanding how different forms of exercise affect immune function. Mechanistic studies are beginning to shed light on how exercise may impair the development of cancer or be used to augment cancer treatment. The beneficial effects of exercise on the immune system may be exploited to improve patient responses to cancer immunotherapy. METHODS: We investigated the effects of acute exercise on the composition of peripheral blood leukocytes over time in a male population of varying fitness...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28428555/application-of-high-resolution-melting-assay-hrm-to-study-temperature-dependent-intraspecific-competition-in-a-pathogenic-bacterium
#19
Roghaieh Ashrafi, Matthieu Bruneaux, Lotta-Riina Sundberg, Katja Pulkkinen, Tarmo Ketola
Studies on species' responses to climate change have focused largely on the direct effect of abiotic factors and in particular temperature, neglecting the effects of biotic interactions in determining the outcome of climate change projections. Many microbes rely on strong interference competition; hence the fitness of many pathogenic bacteria could be a function of both their growth properties and intraspecific competition. However, due to technical challenges in distinguishing and tracking individual strains, experimental evidence on intraspecific competition has been limited so far...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428330/genomic-responses-to-socio-sexual-environment-in-male-drosophila-melanogaster-exposed-to-conspecific-rivals
#20
Irina I Mohorianu, Amanda Bretman, Damian T Smith, Emily Fowler, Tamas Dalmay, Tracey Chapman
Socio-sexual environments have profound effects on fitness. Local sex ratios can alter the threat of sexual competition, to which males respond via plasticity in reproductive behaviours and ejaculate composition. In Drosophila melanogaster, males detect the presence of conspecific mating rivals prior to mating using multiple, redundant sensory cues. Males that respond to rivals gain significant fitness benefits by altering mating duration and ejaculate composition. Here we investigated the underlying genome-wide changes involved...
April 20, 2017: RNA
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