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Immune-mediated neuritis

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https://www.readbyqxmd.com/read/27896635/discovery-and-initial-characterization-of-th9-cells-the-early-years
#1
REVIEW
Edgar Schmitt, Tobias Bopp
The launch of the Th1/Th2 concept represented a decisive breakthrough concerning our understanding of how very diverse immune reactions can be regulated by functionally different T helper subpopulations via the secretion of different panels of cytokines. In this context, IL-9 was identified to be produced by T helper cell lines in addition to Th2 cytokines IL-4 and IL-5. Detailed analyses revealed that IL-9 production of mouse CD4(+) T helper cells was dependent on a combination of IL-2, IL-4, and TGF-β. Roughly a decade later, it was found that TGF-β can also induce the development of CD4(+) Treg cells...
November 28, 2016: Seminars in Immunopathology
https://www.readbyqxmd.com/read/27878436/peripheral-nerve-ultrasound-scoring-systems-benchmarking-and-comparative-analysis
#2
Alexander Grimm, Tim W Rattay, Natalie Winter, Hubertus Axer
Ultrasound of the nerves is an additive diagnostic tool to evaluate polyneuropathy. Recently, the need for standardized scoring systems has widely been discussed; different scores are described so far. Therefore, 327 patients with polyneuropathy were analyzed by ultrasound in our laboratory. Consequently, several ultrasound scoring tools were applied, i.e., the nerve pattern classification according to Padua et al. in all patients with CIDP and variants, the Bochum ultrasound score (BUS) and the neuritis ultrasound protocol in immune-mediated neuritis, the ultrasound pattern sum score, the homogeneity score, and the nerve enlargement distribution score in all neuropathies if possible...
November 22, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27861905/attenuation-of-experimental-autoimmune-neuritis-with-locally-administered-lovastatin-encapsulating-plga-nanoparticles
#3
Kelly A Langert, Bruktawit Goshu, Evan B Stubbs
Acute inflammatory demyelinating polyneuropathy (AIDP) is an aggressive antibody- and T cell-mediated variant of Guillain-Barré Syndrome (GBS), a prominent and debilitating autoimmune disorder of the peripheral nervous system. Despite advancements in clinical management, treatment of patients with AIDP/GBS and its chronic variant CIDP remains palliative and relies on the use of non-specific immune-modulating therapies. Our laboratory has previously reported that therapeutic administration of statins safely attenuates the clinical severity of experimental autoimmune neuritis (EAN), a well-characterized animal model of AIDP/GBS, by restricting the migration of autoreactive leukocytes across peripheral nerve microvascular endoneurial endothelial cells (PNMECs) that form the blood-nerve barrier...
November 8, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27817222/tumor-necrosis-factor-%C3%AE-in-guillain-barr%C3%A3-syndrome-friend-or-foe
#4
Ying Wang, Jingdian Zhang, Peijuan Luo, Jie Zhu, Jiachun Feng, Hong-Liang Zhang
Guillain-Barré syndrome (GBS) is an immune-mediated disorder in the peripheral nervous system (PNS), and experimental autoimmune neuritis (EAN) serves as an animal model of GBS. TNF-α plays an important role in the pathogenesis of GBS and is a potential therapeutic target of GBS. Areas covered: "TNF-α" and "Guillain-Barré syndrome" were the keywords used to search for related publications on Pubmed. By binding to different TNF receptors, TNF-α bears distinct immune properties. TNF-α gene polymorphisms are associated with the features of GBS...
November 6, 2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/27777775/acute-visual-loss-after-ipilimumab-treatment-for-metastatic-melanoma
#5
Melissa A Wilson, Kelly Guld, Steven Galetta, Ryan D Walsh, Julia Kharlip, Madhura Tamhankar, Suzanne McGettigan, Lynn M Schuchter, Leslie A Fecher
BACKGROUND: Ipilimumab, a humanized CLTA-4 antibody is a standard therapy in the treatment of advanced melanoma. While ipilimumab provides an overall survival benefit to patients, it can be associated with immune related adverse events (IrAEs). CASE PRESENTATION: Here we describe a patient treated with ipilimumab who experienced known IrAEs, including hypophysitis, as well as a profound vision loss due to optic neuritis. There are rare reports of optic neuritis occurring as an adverse event associated with ipilimumab treatment...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27732973/diagnostic-utility-of-systematic-aquaporin-4-antibodies-determination-in-the-first-event-of-immune-mediated-optic-neuritis
#6
Edgar Carnero Contentti, Mariana De Virgiliis, Javier Pablo Hryb, Felisa Leguizamon, Julia Celso, José Luis Di Pace, Mónica Perassolo
BACKGROUND: Antibodies against aquaporin-4 (AQP4-ab) have diagnostic and prognostic value. However, little is known to date about their utility in the first event of optic neuritis (ON). OBJECTIVE: To evaluate the utility of systematic AQP4-ab determination in a retrospective cohort of patients with a first onset of ON. PATIENTS AND METHODS: All patients (n = 42) were tested for AQP4-ab in the following context: typical ON (TON) and atypical ON (AON)...
2016: European Neurology
https://www.readbyqxmd.com/read/27629711/resolvin-d1-programs-inflammation-resolution-by-increasing-tgf-%C3%AE-expression-induced-by-dying-cell-clearance-in-experimental-autoimmune-neuritis
#7
Bangwei Luo, Fuyu Han, Kai Xu, Jinsong Wang, Zongwei Liu, Zigang Shen, Jia Li, Yu Liu, Man Jiang, Zhi-Yuan Zhang, Zhiren Zhang
UNLABELLED: Experimental autoimmune neuritis (EAN) is the animal model of human acute inflammatory demyelinating polyradiculoneuropathies (AIDP), an auto-immune inflammatory demyelination disease of the peripheral nervous system (PNS) and the world's leading cause of acute autoimmune neuromuscular paralysis. EAN and AIDP are characterized by self-limitation with spontaneous recovery; however, endogenous pathways that regulate inflammation resolution in EAN and AIDP remain elusive. A pathway of endogenous mediators, especially resolvins and clearance of apoptotic cells, may be involved...
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27402111/neuromyelitis-optica-devic-s-syndrome-an-appraisal
#8
REVIEW
Teresa M Crout, Laura P Parks, Vikas Majithia
Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD), previously known as Devic's syndrome, are a group of inflammatory disorders of the central nervous system (CNS) characterized by severe, immune-mediated demyelination and axonal damage, predominantly targeting optic nerves and the spinal cord typically associated with a disease-specific serum NMO-IgG antibody that selectively binds aquaporin-4 (AQP4). The classic and best-defined features of NMOSD include acute attacks of bilateral or rapidly sequential optic neuritis (leading to visual loss) or transverse myelitis (often causing limb weakness and bladder dysfunction) or both with a typically relapsing course...
August 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27220616/encephalitic-arboviruses-emergence-clinical-presentation-and-neuropathogenesis
#9
REVIEW
Hamid Salimi, Matthew D Cain, Robyn S Klein
Arboviruses are arthropod-borne viruses that exhibit worldwide distribution, contributing to systemic and neurologic infections in a variety of geographical locations. Arboviruses are transmitted to vertebral hosts during blood feedings by mosquitoes, ticks, biting flies, mites, and nits. While the majority of arboviral infections do not lead to neuroinvasive forms of disease, they are among the most severe infectious risks to the health of the human central nervous system. The neurologic diseases caused by arboviruses include meningitis, encephalitis, myelitis, encephalomyelitis, neuritis, and myositis in which virus- and immune-mediated injury may lead to severe, persisting neurologic deficits or death...
July 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27149333/folliculocentric-herpes-a-clinicopathological-study-of-28-patients
#10
A Neil Crowson, Jad Saab, Cynthia M Magro
BACKGROUND: The cutaneous manifestations of herpes infection are primarily in the context of active infection and of the post-herpetic zosteriform eruption. The former manifests cytopathic alterations diagnostic of herpes. The latter includes lichen planus-like and granuloma annulare-like eruptions and lymphocytoma cutis. METHODS: We encountered skin biopsies from 28 patients whose acute or chronic herpetic or post-herpetic zosteriform lesions manifested folliculocentricity...
May 3, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27142843/dimethyl-fumarate-attenuates-experimental-autoimmune-neuritis-through-the-nuclear-factor-erythroid-derived-2-related-factor-2-hemoxygenase-1-pathway-by-altering-the-balance-of-m1-m2-macrophages
#11
Ranran Han, Jinting Xiao, Hui Zhai, Junwei Hao
BACKGROUND: Guillain-Barré syndrome (GBS) is an acute, post-infectious, immune-mediated, demyelinating disease of peripheral nerves and nerve roots. Dimethyl fumarate (DMF), a fumaric acid ester, exhibits various biological activities, including multiple immunomodulatory and neuroprotective effects. However, the potential mechanism underlying the effect of DMF in GBS animal model experimental autoimmune neuritis (EAN) is unclear. METHODS: Using EAN, an established GBS model, we investigated the effect of DMF by assessing clinical score, histological staining and electrophysiological studies...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27063582/rad001-everolimus-attenuates-experimental-autoimmune-neuritis-by-inhibiting-the-mtor-pathway-elevating-akt-activity-and-polarizing-m2-macrophages
#12
Ranran Han, Juan Gao, Hui Zhai, Jinting Xiao, Ya'nan Ding, Junwei Hao
Guillain-Barre' syndrome (GBS) is an acute, postinfectious, immune-mediated, demyelinating disease of peripheral nerves and nerve roots. As a classical animal model of GBS, experimental autoimmune neuritis (EAN) has become well-accepted. Additionally, the potent immune modulation exerted by mammalian target of rapamycin (mTOR) inhibitors has been used to treat cancers and showed beneficial effects. Here we demonstrate that the mTOR inhibitor RAD001 (everolimus) protected rats from the symptoms of EAN, as shown by decreased paralysis, diminished inflammatory cell infiltration, reductions in demyelination of peripheral nerves and improved nerve conduction...
June 2016: Experimental Neurology
https://www.readbyqxmd.com/read/26954363/th17-cells-in-neuromyelitis-optica-spectrum-disorder-a-review
#13
Jie Lin, Xiang Li, Junhui Xia
Neuromyelitis optica spectrum disorder (NMOSD) has been identified as a central nervous system (CNS) autoimmune inflammatory disorder, which has been recognized as a B cell-mediated humoral immune disease. However, cases have been reported indicating that some of the neuromyelitis optica (NMO) patients have been resistant to B cell-related treatments. Recently, more and more evidence has shown that T cell-mediated immunity may take part in the pathogenesis of NMOSD, especially in the Th17 phenotype. In our PUBMED search, we used the following keywords: Th17 cell, Th17 cell-related cytokines, T cells, B cells, B cell-related productions, NMO, NMOSD, recurrent/bilateral optic neuritis, recurrent transverse myelitis and longitudinally extensive transverse myelitis...
December 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26528293/evidence-from-human-and-animal-studies-pathological-roles-of-cd8-t-cells-in-autoimmune-peripheral-neuropathies
#14
REVIEW
Mu Yang, Corentin Peyret, Xiang Qun Shi, Nicolas Siron, Jeong Ho Jang, Sonia Wu, Sylvie Fournier, Ji Zhang
Autoimmune peripheral neuropathies such as Guillain-Barre Syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) affect millions of people worldwide. Despite significant advances in understanding the pathology, the molecular and cellular mechanisms of immune-mediated neuropathies remain elusive. T lymphocytes definitely play an important role in disease pathogenesis and CD4(+) T cells have been the main area of research for decades. This is partly due to the fact that the most frequent animal model to study autoimmune peripheral neuropathy is experimental allergic neuritis (EAN)...
2015: Frontiers in Immunology
https://www.readbyqxmd.com/read/26468870/neuromyelitis-optica-and-neuromyelitis-optica-spectrum-disorder-patients-in-turkish-cohort-demographic-clinical-and-laboratory-features
#15
Ayse Altintas, Rana Karabudak, Belgin P Balci, Murat Terzi, Aysun Soysal, Sabahattin Saip, Asli Tuncer Kurne, Ugur Uygunoglu, Mecbure Nalbantoglu, Gokcen Gozubatik Celik, Nihal Isik, Yahya Celik, Figen Gokcay, Taskin Duman, Cavit Boz, Canan Yucesan, Mehmet Serhat Mangan, Nese Celebisoy, Sevda Diker, Ilksen Colpak Isikay, Tulay Kansu, Aksel Siva
BACKGROUND: Neuromyelitis optica (NMO) is an immune-mediated, chronic relapsing, inflammatory disease characterized by severe attacks of optic neuritis and myelitis. OBJECTIVE: To determine the demographic, clinical, and laboratory features; antibody status; and treatment modalities of patients with NMO and neuromyelitis optica spectrum disorders in a Turkish cohort from 11 centers. METHODS: A total of 182 patients were included in this study...
October 2015: Neurologist
https://www.readbyqxmd.com/read/26357850/are-th17-cells-and-their-cytokines-a-therapeutic-target-in-guillain-barr%C3%A3-syndrome
#16
REVIEW
Xiujuan Wu, Juan Wang, Kangding Liu, Jie Zhu, Hong-Liang Zhang
INTRODUCTION: Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory disorder of the peripheral nervous system (PNS). Experimental autoimmune neuritis (EAN) is a useful animal model for studying GBS. Currently, GBS remains a life-threatening disorder and more effective therapeutic strategies are in urgent need. AREAS COVERED: Accumulating evidence has revealed that T helper (Th) 17 cells and their cytokines are pathogenic in GBS/EAN. Drugs attenuated clinical signs of GBS/EAN, in part, by decreasing Th17 cells or IL-17A...
2016: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/26351858/enlist-1-an-international-multi-centre-cross-sectional-study-of-the-clinical-features-of-erythema-nodosum-leprosum
#17
MULTICENTER STUDY
Stephen L Walker, Marivic Balagon, Joydeepa Darlong, Shimelis N Doni, Deanna A Hagge, Vikas Halwai, Annamma John, Saba M Lambert, Armi Maghanoy, Jose A C Nery, Kapil D Neupane, Peter G Nicholls, Vivek V Pai, Pawan Parajuli, Anna M Sales, Euzenir Sarno, Mahesh Shah, Digafe Tsegaye, Diana N J Lockwood
Erythema nodosum leprosum (ENL) is a severe multisystem immune mediated complication of borderline lepromatous leprosy and lepromatous leprosy. ENL is associated with skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. The treatment of ENL requires immunosuppression, which is often required for prolonged periods of time and may lead to serious adverse effects. ENL and its treatment is associated with increased mortality and economic hardship. Improved, evidence-based treatments for ENL are needed; however, defining the severity of ENL and outcome measures for treatment studies is difficult because of the multiple organ systems involved...
2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26318182/roles-of-treg-th17-cell-imbalance-and-neuronal-damage-in-the-visual-dysfunction-observed-in-experimental-autoimmune-optic-neuritis-chronologically
#18
Yuanyuan Liu, Caiyun You, Zhuhong Zhang, Jingkai Zhang, Hua Yan
Optic neuritis associated with multiple sclerosis and its animal model, experimental autoimmune optic neuritis (EAON), is characterized by inflammation, T cell activation, demyelination, and neuronal damage, which might induce permanent vision loss. Elucidating the chronological relationship among the features is critical for treatment of demyelinating optic neuritis. EAON was induced in C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein subcutaneously, and visual function was assessed by flash-visual evoked potential (F-VEP) at days 7, 11, 14, 19, 23, 28 post-immunization...
December 2015: Neuromolecular Medicine
https://www.readbyqxmd.com/read/26304919/complex-type-2-reactions-in-three-patients-with-hansen-s-disease-from-a-southern-united-states-clinic
#19
Kristoffer E Leon, Jorge L Salinas, Robert W McDonald, Anandi N Sheth, Jessica K Fairley
In non-endemic countries, leprosy, or Hansen's disease (HD), remains rare and is often underrecognized. Consequently, the literature is currently lacking in clinical descriptions of leprosy complications in the United States. Immune-mediated inflammatory states known as reactions are common complications of HD. Type 1 reactions are typical of borderline cases and occur in 30% of patients and present as swelling and inflammation of existing skin lesions, neuritis, and nerve dysfunction. Type 2 reactions are systemic events that occur at the lepromatous end of the disease spectrum, and typical symptoms include fever, arthralgias, neuritis, and classic painful erythematous skin nodules known as erythema nodosum leprosum...
November 2015: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/26183571/varicella-zoster-virus-specific-cell-mediated-immunity-in-ramsay-hunt-syndrome
#20
Shin-ichi Haginomori, Takahiro Ichihara, Atsuko Mori, Atsuko Kanazawa, Ryo Kawata, Huamin Tang, Yasuko Mori
OBJECTIVES/HYPOTHESIS: The etiology of Ramsay Hunt syndrome (Hunt syndrome) is reactivation of latent varicella-zoster virus (VZV) in the geniculate ganglion of the facial nerve, leading to neuritis. Although the mechanism of the VZV reactivation is unclear, one possibility is that the reactivation involves a low level of VZV-specific cell-mediated immunity (CMI). The aim of this study was to clarify the characteristics of the VZV-specific CMI in Hunt syndrome compared to that in Bell's palsy, and to obtain clues to its role in the development of Hunt syndrome...
January 2016: Laryngoscope
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