Ahmad Salameh, Alessandro K Lee, Marina Cardó-Vila, Diana N Nunes, Eleni Efstathiou, Fernanda I Staquicini, Andrey S Dobroff, Serena Marchiò, Nora M Navone, Hitomi Hosoya, Richard C Lauer, Sijin Wen, Carolina C Salmeron, Anh Hoang, Irene Newsham, Leandro A Lima, Dirce M Carraro, Salvatore Oliviero, Mikhail G Kolonin, Richard L Sidman, Kim-Anh Do, Patricia Troncoso, Christopher J Logothetis, Ricardo R Brentani, George A Calin, Webster K Cavenee, Emmanuel Dias-Neto, Renata Pasqualini, Wadih Arap
Prostate cancer antigen 3 (PCA3) is the most specific prostate cancer biomarker but its function remains unknown. Here we identify PRUNE2, a target protein-coding gene variant, which harbors the PCA3 locus, thereby classifying PCA3 as an antisense intronic long noncoding (lnc)RNA. We show that PCA3 controls PRUNE2 levels via a unique regulatory mechanism involving formation of a PRUNE2/PCA3 double-stranded RNA that undergoes adenosine deaminase acting on RNA (ADAR)-dependent adenosine-to-inosine RNA editing...
July 7, 2015: Proceedings of the National Academy of Sciences of the United States of America