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https://www.readbyqxmd.com/read/29222257/is-molecular-remission-the-goal-of-multiple-myeloma-therapy
#1
REVIEW
Faith E Davies
The increased number of effective therapies and the wider use of combinations that give deeper remissions have resulted in a reassessment of the goals of myeloma therapy. With the advent of new therapeutic strategies and diagnostic tools, achievement of minimal residual disease (MRD)-negative status has become increasingly important, with some even considering it as the primary endpoint for therapy. The level of MRD that is aimed for is a continuous, rather than an absolute variable, with studies in both transplant-eligible and -noneligible patients showing that the level of MRD achieved is predictive of progression-free survival and overall survival, with an improvement in survival of approximately 1 year for each log-depletion in MRD level...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29214856/physical-activity-interventions-in-faith-based-organizations-a-systematic-review
#2
Maíra Tristão Parra, Gustavo J M Porfírio, Elva M Arredondo, Álvaro N Atallah
OBJECTIVE: To review and assess the effectiveness of physical activity interventions delivered in faith-based organizations. DATA SOURCE: We searched the Cochrane Library, DoPHER, EMBASE, LILACS, MEDLINE, PsycINFO, WHO ICTRP, and Clinicaltrials.gov databases until January 2016, without restriction of language or publication date. STUDY INCLUSION AND EXCLUSION CRITERIA: Randomized and nonrandomized controlled trials investigating physical activity interventions for adults delivered in faith-based organizations...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29210874/ischemic-stroke-patients-decision-making-process-in-their-use-of-western-medicine-and-alternative-and-complementary-medicine
#3
Chen-Ying Hsieh, Shou-Yu Wang, Yeu-Hui Chuang, Ho-Hsiang Chen
Stroke is ranked third among the top 10 causes of death in Taiwan. Besides a high mortality rate, stroke survivors are often left with physical or functional sequela. This study aimed to explore ischemic stroke patients' decision-making process using Western medicine (WM) and complementary and alternative medicine (CAM). This study is a qualitative study based on grounded theory. A total of 12 participants were recruited. Findings revealed that the participants accepted WM and CAM treatments following the onset of ischemic stroke...
January 2018: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29208639/reconstitution-of-female-germ-cell-fate-determination-and-meiotic-initiation-in-mammals
#4
So I Nagaoka, Mitinori Saitou
Meiosis is a fundamental process that underpins sexual reproduction. In mammals, the execution of meiosis is tightly integrated within the complex processes of oogenesis and spermatogenesis, and elucidation of the molecular mechanisms regulating meiotic initiation remains challenging. We have recently developed in vitro culture strategies to induce mouse pluripotent stem cells into germ cells, which successfully contribute to both oogenesis and spermatogenesis and to fertile offspring. The culture strategies faithfully recapitulate transcriptional and epigenetic dynamics as well as signaling principles for germ cell specification, proliferation, and female sex determination/meiotic induction, providing a valuable platform for studies to illuminate the molecular mechanisms underlying such critical processes...
December 5, 2017: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29199870/spiritual-struggles-and-interleukin-6-assessing-potential-benefits-and-potential-risks
#5
Neal Krause, Kenneth I Pargament, Gail Ironson, R David Hayward
The purpose of this study is to evaluate the relationship between spiritual struggles and levels of interleukin-6 (IL-6) with a subsample (N = 943) of participants who took part in a nationwide survey. This study, which was completed in 2014, was conducted in the United States. Spiritual struggles refer to difficulties that a person may encounter with his or her faith and include having a troubled relationship with God, encountering difficulties with religious others, and being unable to find a sense of ultimate meaning in life...
2017: Biodemography and Social Biology
https://www.readbyqxmd.com/read/29198730/designing-a-randomized-controlled-trial-to-evaluate-a-community-based-narrative-intervention-for-improving-colorectal-cancer-screening-for-african-americans
#6
Erin M Ellis, Deborah O Erwin, Lina Jandorf, Frances Saad-Harfouche, Pathu Sriphanlop, Nikia Clark, Cassandre Dauphin, Detric Johnson, Lynne B Klasko-Foster, Clarissa Martinez, Jamilia Sly, Drusilla White, Gary Winkel, Marc T Kiviniemi
OBJECTIVE: To describe the methodology of a 2-arm randomized controlled trial that compared the effects of a narrative and didactic version of the Witness CARES (Community Awareness, Reach, & Empowerment for Screening) intervention on colorectal cancer screening behavior among African Americans, as well as the cognitive and affective determinants of screening. METHODS: Witness CARES targeted cognitive and affective predictors of screening using a culturally competent, community-based, narrative or didactic communication approach...
November 30, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29198315/mimicking-the-effects-of-spaceflight-on-bone-combined-effects-of-disuse-and-chronic-low-dose-rate-radiation-exposure-on-bone-mass-in-mice
#7
Kanglun Yu, Alison H Doherty, Paula C Genik, Sara E Gookin, Danielle M Roteliuk, Samantha J Wojda, Zhi-Sheng Jiang, Meghan E McGee-Lawrence, Michael M Weil, Seth W Donahue
During spaceflight, crewmembers are subjected to biomechanical and biological challenges including microgravity and radiation. In the skeleton, spaceflight leads to bone loss, increasing the risk of fracture. Studies utilizing hindlimb suspension (HLS) as a ground-based model of spaceflight often neglect the concomitant effects of radiation exposure, and even when radiation is accounted for, it is often delivered at a high-dose rate over a very short period of time, which does not faithfully mimic spaceflight conditions...
November 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29196319/object-representations-in-human-visual-cortex-formed-through-temporal-integration-of-dynamic-partial-shape-views
#8
Tanya Orlov, Ehud Zohary
We typically recognize visual objects, by utilizing the spatial layout of their parts, simultaneously present on the retina. Thus, shape extraction is based on integration of the relevant retinal information over space. The lateral occipital complex (LOC) can faithfully represent shape in such conditions. However, sometimes, integration over time is required to determine object shape. To study shape extraction through temporal integration of successive partial-shape views, we presented human participants (both men and women) with artificial shapes that moved behind a narrow vertical or horizontal slit...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29195190/courtesy-stigma-a-concealed-consternation-among-caregivers-of-people-affected-by-leprosy
#9
Mavis Dako-Gyeke
This study explored experiences of courtesy stigma among caregivers of people affected by leprosy. Using a qualitative research approach, twenty participants were purposively selected and in-depth interviews conducted. The interviews were audio-recorded, transcribed, and analyzed to identify emerging themes that addressed objectives of the study. The findings indicated that caregivers of people affected by leprosy experienced courtesy stigma. Evidence showed that fear of contagion underpinned caregivers' experiences, especially in employment and romantic relationships...
November 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29188232/colorectal-cancer-cells-adhere-to-and-migrate-along-the-neurons-of-the-enteric-nervous-system
#10
Emilie Duchalais, Christophe Guilluy, Steven Nedellec, Melissa Touvron, Anne Bessard, Yann Touchefeu, Céline Bossard, Hélène Boudin, Guy Louarn, Michel Neunlist, Laurianne Van Landeghem
Background & Aims: In several types of cancers, tumor cells invade adjacent tissues by migrating along the resident nerves of the tumor microenvironment. This process, called perineural invasion, typically occurs along extrinsic nerves, with Schwann cells providing physical guidance for the tumor cells. However, in the colorectal cancer microenvironment, the most abundant nervous structures belong to the nonmyelinated intrinsic enteric nervous system (ENS). In this study, we investigated whether colon cancer cells interact with the ENS...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29174952/interactions-between-diet-and-the-intestinal-microbiota-alter-intestinal-permeability-and-colitis-severity-in-mice
#11
Sean R Llewellyn, Graham J Britton, Eduardo J Contijoch, Olivia H Vennaro, Arthur Mortha, Jean-Frederic Colombel, Ari Grinspan, Jose C Clemente, Miriam Merad, Jeremiah J Faith
BACKGROUND & AIMS: It is not clear how the complex interactions between diet and the intestinal microbiota affect development of mucosal inflammation or inflammatory bowel disease. We investigated interactions between dietary ingredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice given more than 40 unique diets; we quantified individual and synergistic effects of dietary macronutrients and the microbiota on intestinal health and development of colitis...
November 23, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29172987/claim-more%C3%A2-empowering-african-american-women-to-make-healthy-choices
#12
Rifky Tkatch, Shirley Musich, Jennifer Draklellis, Marla Hetzel, Jo Banks, Jessica Dugan, Kaylene Thompson, Kevin Hawkins
Diabetes is a serious issue for African American women. The purpose of this project was to develop and test the feasibility of a culturally appropriate and faith-based healthy eating program for African American women at risk for developing diabetes. At total of 30 women from two churches completed a 12-week, faith-based program using a community-based approach with lay health educators in the church setting. Participants set healthy eating goals, attended weekly education classes, and received daily text messaging reminders related to their goals...
February 1, 2017: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/29171825/guardians-of-the-mycobacterial-genome-a-review-on-dna-repair-systems-in-mycobacterium-tuberculosis
#13
Amandeep Singh
The genomic integrity of Mycobacterium tuberculosis is continuously threatened by the harsh survival conditions inside host macrophages, due to immune and antibiotic stresses. Faithful genome maintenance and repair must be accomplished under stress for the bacillus to survive in the host, necessitating a robust DNA repair system. The importance of DNA repair systems in pathogenesis is well established. Previous examination of the M. tuberculosis genome revealed homologues of almost all the major DNA repair systems, i...
November 24, 2017: Microbiology
https://www.readbyqxmd.com/read/29170075/reducing-depressive-symptoms-through-behavioral-activation-in-churches-a-hybrid-2-randomized-effectiveness-implementation-design
#14
Tiffany Haynes, Jerome Turner, Johnny Smith, Geoffrey Curran, Keneshia Bryant-Moore, Songthip T Ounpraseuth, Teresa Kramer, Kimberly Harris, Ellen Hutchins, Karen Hye-Cheon Kim Yeary
Rural African Americans are disproportionately exposed to numerous stressors such as poverty that place them at risk for experiencing elevated levels of depressive symptoms. Effective treatments for decreasing depressive symptoms exist, but rural African Americans often fail to receive adequate and timely care. Churches have been used to address physical health outcomes in rural African American communities, but few have focused primarily on addressing mental health outcomes. Our partnership, consisting of faith community leaders and academic researchers, adapted an evidence-based behavioral activation intervention for use with rural African American churches...
November 20, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29169465/research-techniques-made-simple-emerging-methods-to-elucidate-protein-interactions-through-spatial-proximity
#15
Yonglu Che, Paul A Khavari
Interactions between proteins are essential for fundamental cellular processes, and the diversity of such interactions enables the vast variety of functions essential for life. A persistent goal in biological research is to develop assays that can faithfully capture different types of protein interactions to allow their study. A major step forward in this direction came with a family of methods that delineates spatial proximity of proteins as an indirect measure of protein-protein interaction. A variety of enzyme- and DNA ligation-based methods measure protein co-localization in space, capturing novel interactions that were previously too transient or low affinity to be identified...
December 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29167736/on-the-interpretability-and-computational-reliability-of-frequency-domain-granger-causality
#16
Luca Faes, Sebastiano Stramaglia, Daniele Marinazzo
This Correspondence article is a comment which directly relates to the paper "A study of problems encountered in Granger causality analysis from a neuroscience perspective" ( Stokes and Purdon, 2017). We agree that interpretation issues of Granger causality (GC) in neuroscience exist, partially due to the historically unfortunate use of the name "causality", as described in previous literature. On the other hand, we think that Stokes and Purdon use a formulation of GC which is outdated (albeit still used) and do not fully account for the potential of the different frequency-domain versions of GC; in doing so, their paper dismisses GC measures based on a suboptimal use of them...
2017: F1000Research
https://www.readbyqxmd.com/read/29161471/peer-to-peer-mentoring-for-african-american-women-with-lupus-a-feasibility-pilot
#17
Edith M Williams, J Madison Hyer, Ramakrishnan Viswanathan, Trevor D Faith, Delia Voronca, Mulugeta Gebregzaibher, Jim C Oates, Leonard Egede
OBJECTIVE: To examine the feasibility and potential benefits of peer mentoring to improve the disease self-management and quality of life of individuals with systemic lupus erythematosus (SLE). METHODS: Peer mentors were trained and paired with up to three mentees to receive self-management education and support by telephone over 12 weeks. This study took place at an academic teaching hospital in Charleston, South Carolina. Seven quads consisting of one peer mentor and three mentees were matched based on factors such as age, area of residence, marital and work status...
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29160826/the-communication-awareness-relationships-and-empowerment-c-a-r-e-model-an-effective-tool-for-engaging-urban-communities-in-community-based-participatory-research
#18
Joniqua Ceasar, Marlene H Peters-Lawrence, Valerie Mitchell, Tiffany M Powell-Wiley
Little is known about recruitment methods for racial/ethnic minority populations from resource-limited areas for community-based health and needs assessments, particularly assessments that incorporate mobile health (mHealth) technology for characterizing physical activity and dietary intake. We examined whether the Communication, Awareness, Relationships and Empowerment (C.A.R.E.) model could reduce challenges recruiting and retaining participants from faith-based organizations in predominantly African American Washington, D...
November 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29145454/reduction-of-hiv-associated-excess-mortality-by-antiretroviral-treatment-among-tuberculosis-patients-in-kenya
#19
Dickens O Onyango, Courtney M Yuen, Kevin P Cain, Faith Ngari, Enos O Masini, Martien W Borgdorff
BACKGROUND: Mortality from TB continues to be a global public health challenge. TB ranks alongside Human Immunodeficiency Virus (HIV) as the leading infectious causes of death globally. HIV is a major driver of TB related morbidity and mortality while TB is the leading cause of mortality among people living with HIV/AIDS. We sought to determine excess mortality associated with HIV and the effect of antiretroviral therapy on reducing mortality among tuberculosis patients in Kenya. METHODS: We conducted a retrospective analysis of Kenya national tuberculosis program data of patients enrolled from 2013 through 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29142123/initiation-elongation-and-realignment-during-influenza-virus-mrna-synthesis
#20
Aartjan J W Te Velthuis, Judith Oymans
The RNA-dependent RNA polymerase (RdRp) of the influenza A virus replicates and transcribes the viral genome segments in the nucleus of the host cell. To transcribe these viral genome segments, the RdRp 'snatches' capped RNA oligonucleotides from nascent host cell mRNAs and aligns these primers to the ultimate or penultimate nucleotide of the segments for the initiation of viral mRNA synthesis. It has been proposed that this initiation process is not processive and that the RdRp uses a prime-realign mechanism during transcription...
November 15, 2017: Journal of Virology
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