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https://www.readbyqxmd.com/read/29173937/relationship-between-ultrasonic-marker-of-fetal-lung-maturity-and-lamellar-body-count
#1
Khadije Rezaie Keikhaie, Kolsoum Rezaie Kahkhaie, Nooshin Mohammadi, Nooshin Amjadi, Aliye Ahmadi Forg, Abbas Ali Ramazani
BACKGROUND: The aim of this study was prediction the fetal lung maturity by ultrasonic markers and comparison by lamellar body count and fetal outcome. METHODS: A prospective Longitudinal study Department of perinatology of performed Emam Khomeini hospital and Mirza Kochak Khan Hospital in Tehran, Iran from March 2013 to January 2014. 100 pregnant women (37-40 weeks of gestation) who were admitted for elective cesarean section and referred for an obstetric ultrasound scan at the same day of their elective cesarean section were included...
January 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29167063/intramuscular-administration-potentiates-extended-dwell-time-of-mesenchymal-stromal-cells-compared-to-other-routes
#2
Lorena R Braid, Catherine A Wood, Danielle M Wiese, Barry N Ford
BACKGROUND: Mesenchymal stromal cells (MSCs) offer great potential for diverse clinical applications. However, conventional systemic infusion of MSCs limits their therapeutic benefit, since intravenously (IV) infused cells become entrapped in the lungs where their dwell time is short. METHODS: To explore possible alternatives to IV infusion, we used in vivo optical imaging to track the bio-distribution and survival of 1 million bioluminescent MSCs administered IV, intraperitoneally (IP), subcutaneously (SC) and intramuscularly (IM) in healthy athymic mice...
November 19, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29057922/a-trade-off-between-cognitive-and-physical-performance-with-relative-preservation-of-brain-function
#3
Daniel Longman, Jay T Stock, Jonathan C K Wells
Debate surrounds the issue of how the large, metabolically expensive brains of Homo sapiens can be energetically afforded. At the evolutionary level, decreased investment in muscularity, adiposity and the digestive tract allow for a larger brain. Developmentally, high neo-natal adiposity and preferential distribution of resources to the brain provide an energetic buffer during times of environmental stress. Through an experimental design, we investigated the hypothesis of a trade-off involving brain and muscle at the acute level in humans...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28921477/out-of-pocket-expenditure-and-catastrophic-health-spending-on-maternal-care-in-public-and-private-health-centres-in-india-a-comparative-study-of-pre-and-post-national-health-mission-period
#4
Sanjay K Mohanty, Anshul Kastor
BACKGROUND: The National Health Mission (NHM), one of the largest publicly funded maternal health programs worldwide was initiated in 2005 to reduce maternal, neo-natal and infant mortality and out-of-pocket expenditure (OOPE) on maternal care in India. Though evidence suggests improvement in maternal and child health, little is known on the change in OOPE and catastrophic health spending (CHS) since the launch of NHM. AIM: The aim of this paper is to provide a comprehensive estimate of OOPE and CHS on maternal care by public and private health providers in pre and post NHM periods...
September 18, 2017: Health Economics Review
https://www.readbyqxmd.com/read/28851538/unusual-loss-of-chymosin-in-mammalian-lineages-parallels-neo-natal-immune-transfer-strategies
#5
Mónica Lopes-Marques, Raquel Ruivo, Elza Fonseca, Ana Teixeira, L Filipe C Castro
Gene duplication and loss are powerful drivers of evolutionary change. The role of loss in phenotypic diversification is notably illustrated by the variable enzymatic repertoire involved in vertebrate protein digestion. Among these we find the pepsin family of aspartic proteinases, including chymosin (Cmy). Previous studies demonstrated that Cmy, a neo-natal digestive pepsin, is inactivated in some primates, including humans. This pseudogenization event was hypothesized to result from the acquisition of maternal immune immunoglobulin G (IgG) transfer...
November 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28749979/attitudes-and-decision-making-about-early-infant-versus-early-adolescent-male-circumcision-demand-side-insights-for-sustainable-hiv-prevention-strategies-in-zambia-and-zimbabwe
#6
COMPARATIVE STUDY
Sema K Sgaier, Sunny Sharma, Maria Eletskaya, Ram Prasad, Owen Mugurungi, Bushimbwa Tambatamba, Getrude Ncube, Sinokuthemba Xaba, Alice Nanga, Sehlulekile Gumede-Moyo, Steve Kretschmer
As countries approach their scale-up targets for the voluntary medical male circumcision program for HIV prevention, they are strategizing and planning for the sustainability phase to follow. Global guidance recommends circumcising adolescent (below 14 years) and/or early infant boys (aged 0-60 days), and countries need to consider several factors before prioritizing a cohort for their sustainability phase. We provide community and healthcare provider-side insights on attitudes and decision-making process as a key input for this strategic decision in Zambia and Zimbabwe...
2017: PloS One
https://www.readbyqxmd.com/read/28615158/somatosensory-modulation-of-salivary-gene-expression-and-oral-feeding-in-preterm-infants-randomized-controlled-trial
#7
Steven Michael Barlow, Jill Lamanna Maron, Gil Alterovitz, Dongli Song, Bernard Joseph Wilson, Priya Jegatheesan, Balaji Govindaswami, Jaehoon Lee, Austin Oder Rosner
BACKGROUND: Despite numerous medical advances in the care of at-risk preterm neonates, oral feeding still represents one of the first and most advanced neurological challenges facing this delicate population. Objective, quantitative, and noninvasive assessment tools, as well as neurotherapeutic strategies, are greatly needed in order to improve feeding and developmental outcomes. Pulsed pneumatic orocutaneous stimulation has been shown to improve nonnutritive sucking (NNS) skills in preterm infants who exhibit delayed or disordered nipple feeding behaviors...
June 14, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28424623/notch-signaling-in-ischemic-damage-and-fibrosis-evidence-and-clues-from-the-heart
#8
REVIEW
Silvia Nistri, Chiara Sassoli, Daniele Bani
Notch signaling is a major intercellular coordination mechanism highly conserved throughout evolution. In vertebrates, Notch signaling is physiologically involved in embryo development, including mesenchymal cell commitment, formation of heart tissues and angiogenesis. In post-natal life, Notch signaling is maintained as a key mechanism of cell-cell communication and its dysregulations have been found in pathological conditions such as ischemic and fibrotic diseases. In the heart, Notch takes part in the protective response to ischemia, being involved in pre- and post-conditioning, reduction of reperfusion-induced oxidative stress and myocardial damage, and cardiomyogenesis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28303730/biomechanical-properties-of-the-pelvic-floor-muscles-of-continent-and-incontinent-women-using-an-inverse-finite-element-analysis
#9
M E T Silva, S Brandão, M P L Parente, T Mascarenhas, R M Natal Jorge
Pelvic disorders can be associated with changes in the biomechanical properties in the muscle, ligaments and/or connective tissue form fascia and ligaments. In this sense, the study of their mechanical behavior is important to understand the structure and function of these biological soft tissues. The aim of this study was to establish the biomechanical properties of the pelvic floor muscles of continent and incontinent women, using an inverse finite element analysis (FEA). The numerical models, including the pubovisceral muscle and pelvic bones were built from magnetic resonance (MR) images acquired at rest...
June 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28169188/clinical-outcomes-after-ivf-or-icsi-using-human-blastocysts-derived-from-oocytes-containing-aggregates-of-smooth-endoplasmic-reticulum
#10
Fumiaki Itoi, Yukiko Asano, Masashi Shimizu, Rika Nagai, Kanako Saitou, Hiroyuki Honnma, Yasutaka Murata
In this study the clinical and neo-natal outcomes after transfer of blastocysts derived from oocytes containing aggregates of smooth endoplasmic reticulum (SER) were compared between IVF and intracytoplasmic sperm injection (ICSI) cycles. Clinical and neo-natal outcomes of blastocysts in cycles with at least one SER metaphase II oocyte (SER + MII; SER + cycles) did not significantly differ between the two insemination methods. When SER + MII were cultured to day 5/6, fertilization, embryo cleavage and blastocyst rates were not significantly different between IVF and ICSI cycles...
April 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28162936/obstetric-and-neo-natal-outcomes-of-icsi-cycles-using-pentoxifylline-to-identify-viable-spermatozoa-in-patients-with-immotile-spermatozoa
#11
MULTICENTER STUDY
Purificación Navas, Alessio Paffoni, Giulia Intra, Antonio González-Utor, Ana Clavero, Maria Carmen Gonzalvo, Rocío Díaz, Rocío Peña, Liliana Restelli, Edgardo Somigliana, Enrico Papaleo, Jose A Castilla, Paola Viganò
Pentoxifylline (PF) represents an effective tool in stimulating motility and identifying viable spermatozoa in intracytoplasmic sperm injection (ICSI) patients presenting exclusively with immotile spermatozoa. However, its use is not universally accepted for its possible detrimental effects on oocytes, embryos or newborns. To evaluate whether PF use may affect obstetrical/neo-natal outcomes, 102 patients achieving a clinical pregnancy after a PF-ICSI in four IVF units in Spain and Italy were followed up after delivery...
April 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28098151/juvenile-myelomonocytic-leukemia-associated-variants-are-associated-with-neo-natal-lethal-noonan-syndrome
#12
Heather Mason-Suares, Diana Toledo, Jean Gekas, Katherine A Lafferty, Naomi Meeks, M Cristina Pacheco, David Sharpe, Thomas E Mullen, Matthew S Lebo
Gain-of-function variants in some RAS-MAPK pathway genes, including PTPN11 and NRAS, are associated with RASopathies and/or acquired hematological malignancies, most notably juvenile myelomonocytic leukemia (JMML). With rare exceptions, the spectrum of germline variants causing RASopathies does not overlap with the somatic variants identified in isolated JMML. Studies comparing these variants suggest a stronger gain-of-function activity in the JMML variants. As JMML variants have not been identified as germline defects and have a greater impact on protein function, it has been speculated that they would be embryonic lethal...
April 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28066993/developing-a-biomimetic-tooth-bud-model
#13
Elizabeth E Smith, Weibo Zhang, Nathan R Schiele, Ali Khademhosseini, Catherine K Kuo, Pamela C Yelick
A long-term goal is to bioengineer, fully functional, living teeth for regenerative medicine and dentistry applications. Biologically based replacement teeth would avoid insufficiencies of the currently used dental implants. Using natural tooth development as a guide, a model was fabricated using post-natal porcine dental epithelial (pDE), porcine dental mesenchymal (pDM) progenitor cells, and human umbilical vein endothelial cells (HUVEC) encapsulated within gelatin methacrylate (GelMA) hydrogels. Previous publications have shown that post-natal DE and DM cells seeded onto synthetic scaffolds exhibited mineralized tooth crowns composed of dentin and enamel...
January 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27967605/early-developmental-disruption-of-type-2-deiodinase-pathway-in-mouse-skeletal-muscle-does-not-impair-muscle-function
#14
Daniele L Ignacio, Diego H S Silvestre, Elena Anne-Palmer, Barbara M L C Bocco, Tatiana L Fonseca, Miriam O Ribeiro, Balázs Gereben, Antonio C Bianco, Joao P Werneck-de-Castro
BACKGROUND: Myogenesis is positively regulated by thyroid hormone (triiodothyronine [T3]), which is amplified by the type 2 deiodinase (D2) activation of thyroxine to T3. Global inactivation of the Dio2 gene impairs skeletal muscle (SKM) differentiation and regeneration in response to muscle injury. Given that newborn and adult mice with late developmental SKM Dio2 disruption do not develop a significant phenotype, it was hypothesized that D2 plays an early role in this process. METHODS: This was tested in mice with SKM disruption of Dio2 driven by two early developmental promoters: MYF5 and MYOD...
April 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27412693/fetal-and-neonatal-maxillary-ontogeny-in-extant-humans-and-the-utility-of-prenatal-maxillary-morphology-in-predicting-ancestral-affiliation
#15
Christina L Nicholas
OBJECTIVES: The midface of extant Homo sapiens is known to undergo shape changes through fetal and neo-natal ontogeny; however, little work has been done to quantify these shape changes. Further, while midfacial traits which vary in frequency between populations of extant humans are presumed to develop prenatally, patterns of population-specific variation maxillary shape across ontogeny are not well documented. Only one study of fetal ontogeny which included specific discussion of the midface has taken a three-dimensional geometric morphometric approach, and that study was limited to one population (Japanese)...
November 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27068240/adverse-pregnancy-and-neo-natal-outcomes-after-assisted-reproductive-treatment-in-patients-with-pelvic-endometriosis-a-case-control-study
#16
Marianne Jacques, Thomas Freour, Paul Barriere, Stéphane Ploteau
To assess the impact of endometriosis on obstetric outcomes and to determine whether the severity, location and surgical treatment of the disease before the pregnancy had an impact on the prevalence of these disorders, a monocentric, case-control study was performed. In total, 113 pregnancies obtained by assisted reproductive treatment among patients with endometriosis were matched with control selected among assisted reproductive treatment pregnancies due to male infertility. The main result measures were pregnancy outcome at the obstetrical and neo-natal levels...
June 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/26877350/p-053-incidence-of-prematurity-in-the-hellp-syndrome
#17
S Zelmat, F Mazour, D D Atouche
OBJECTIFS: Hémolysis, Elevated Liver enzyme, Löw Platelets ou HELLP Syndrome est une complication de la pré-éclampsie dans 10 à 20 %. Le HELLP Syndrome n'a pas d'influence sur la morbidité néonatale. Les complications sont essentiellement imputables à la prématurité induite. La mortalité périnatale est évaluée à 22,6 %. Le but de cette étude est d'étudier l'incidence de la prématurité dans le HELLP Syndrome. MéTHODES: Étude prospective mono-centrique réalisée au Service de Gynéco-Obstetrique de EHUO...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26687905/the-impact-of-physiological-oxygen-during-culture-and-vitrification-for-cryopreservation-on-the-outcome-of-extended-culture-in-human-ivf
#18
David K Gardner
Extended culture has facilitated the move to single blastocyst transfer, resulting in significant increases in implantation and live birth rate, while concomitantly reducing fetal loss during pregnancy. However, concerns have been raised regarding subsequent neo-natal outcomes following extended culture. Analysis of the literature reveals differences in outcomes according to geographical region and between individual clinics. A common factor amongst reports of potentially adverse outcomes following blastocyst transfer appears to be that atmospheric (~20%) oxygen was typically employed for embryo culture...
February 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/26634939/the-differential-diagnosis-of-thrombocytopenia-in-pregnancy
#19
REVIEW
Frauke Bergmann, Werner Rath
BACKGROUND: Thrombocytopenia is, after anemia, the second most common abnormality of the complete blood count in pregnancy, with a reported frequency of 6.6% to 11.2%. It has many causes. Thrombocytopenia should be diagnostically evaluated as early as possible in pregnancy, so that the obstetrical management can be accordingly planned to minimize harm to the mother and child. As the various underlying diseases share clinical features and laboratory findings, the differential diagnosis is often a difficult interdisciplinary challenge...
November 20, 2015: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/26363451/impact-of-hospital-delivery-on-child-mortality-an-analysis-of-adolescent-mothers-in-bangladesh
#20
Sarmistha Pal
New medical inventions for saving young lives are not enough if these do not reach the children and the mother. The present paper provides new evidence that institutional delivery can significantly lower child mortality risks, because it ensures effective and timely access to modern diagnostics and medical treatments to save lives. We exploit the exogenous variation in community's access to local health facilities (both traditional and modern) before and after the completion of the 'Women's Health Project' in 2005 (that enhanced emergency obstetric care in women friendly environment) to identify the causal effect of hospital delivery on various mortality rates among children...
October 2015: Social Science & Medicine
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