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https://www.readbyqxmd.com/read/28454190/evaluation-of-the-effect-of-epilobium-angustifolium-aqueous-extract-on-lncap-cell-proliferation-in-in-vitro-and-in-vivo-models
#1
Jakub P Piwowarski, Barbara Bobrowska-Korczak, Iwona Stanisławska, Wojciech Bielecki, Robert Wrzesien, Sebastian Granica, Katarzyna Krupa, Anna K Kiss
Epilobium sp. are commonly used in traditional medicine in the treatment of early stages of benign prostatic hyperplasia and inflammation. It is suggested that a dominating constituent, oenothein B, is responsible for the extracts therapeutic effects. Several bioactivities were established for extracts and oenothein B in various in vitro models, but due to the questionable bioavailability of this dimeric macrocyclic ellagitannin, their significance in the in vivo effects remains unresolved. We have thus focused our attention on a complex comparative investigation of the in vitro and in vivo activities of phytochemically characterized Epilobium angustifolium aqueous extract and oenothein B on prostate cancer cells proliferation...
April 28, 2017: Planta Medica
https://www.readbyqxmd.com/read/28454105/tea-consumption-and-the-risk-of-biliary-tract-cancer-a-systematic-review-and-dose-response-meta-analysis-of-observational-studies
#2
Jianping Xiong, Jianzhen Lin, Anqiang Wang, Yaqin Wang, Ying Zheng, Xinting Sang, Yiyao Xu, Xin Lu, Haitao Zhao
Recent studies have shown that tea consumption is associated with the reduced incidence of some types of cancer, possibly including biliary tract cancer. However, the epidemiological evidences for the association with risk of biliary tract cancer are contradictory. Thus, we performed meta-analysis of published observational studies to assess the association between tea consumption and risk of biliary tract cancer. Relevant studies were identified by searching PubMed, EMBASE, and ISI Web of Science published before October 2016...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454102/an-inverse-association-between-tea-consumption-and-colorectal-cancer-risk
#3
Yuetong Chen, Yuan Wu, Mulong Du, Haiyan Chu, Lingjun Zhu, Na Tong, Zhengdong Zhang, Meilin Wang, Dongying Gu, Jinfei Chen
It is well known that the tea extracts, mainly polyphenols as chemo-preventive elements, could act as cancer progression blockers. Although the association between tea consumption and colorectal cancer risk has been widely investigated, the results still remain inconsistent. We conducted a dose-response meta-analysis to evaluate their relationships by enrolling qualified 29 literatures. The summary odds ratio (OR) of colorectal cancer for the highest vs. lowest tea consumption was 0.93 with 0.87-1.00 of 95% confidence intervals (CIs) among all studies with modest heterogeneity (P = 0...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454037/agricultural-expansion-as-risk-to-endangered-wildlife-pesticide-exposure-in-wild-chimpanzees-and-baboons-displaying-facial-dysplasia
#4
Sabrina Krief, Philippe Berny, Francis Gumisiriza, Régine Gross, Barbara Demeneix, Jean Baptiste Fini, Colin A Chapman, Lauren J Chapman, Andrew Seguya, John Wasswa
Prenatal exposure to environmental endocrine disruptors can affect development and induce irreversible abnormalities in both humans and wildlife. The northern part of Kibale National Park, a mid-altitude rainforest in western Uganda, is largely surrounded by industrial tea plantations and wildlife using this area (Sebitoli) must cope with proximity to human populations and their activities. The chimpanzees and baboons in this area raid crops (primarily maize) in neighboring gardens. Sixteen young individuals of the 66 chimpanzees monitored (25%) exhibit abnormalities including reduced nostrils, cleft lip, limb deformities, reproductive problems and hypopigmentation...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28453515/reliable-reference-genes-for-normalization-of-gene-expression-data-in-tea-plants-camellia-sinensis-exposed-to-metal-stresses
#5
Ming-Le Wang, Qing-Hui Li, Hua-Hong Xin, Xuan Chen, Xu-Jun Zhu, Xing-Hui Li
Tea plants [Camellia sinensis (L.) O. Kuntze] are an important leaf-type crop that are widely used for the production of non-alcoholic beverages in the world. Exposure to excessive amounts of heavy metals adversely affects the quality and yield of tea leaves. To analyze the molecular responses of tea plants to heavy metals, a reliable quantification of gene expression is important and of major importance herein is the normalization of the measured expression levels for the target genes. Ideally, stably expressed reference genes should be evaluated in all experimental systems...
2017: PloS One
https://www.readbyqxmd.com/read/28453261/comparison-of-metabolomics-approaches-for-evaluating-the-variability-of-complex-botanical-preparations-green-tea-camellia-sinensis-as-a-case-study
#6
Joshua J Kellogg, Tyler N Graf, Mary F Paine, Jeannine S McCune, Olav M Kvalheim, Nicholas H Oberlies, Nadja B Cech
A challenge that must be addressed when conducting studies with complex natural products is how to evaluate their complexity and variability. Traditional methods of quantifying a single or a small range of metabolites may not capture the full chemical complexity of multiple samples. Different metabolomics approaches were evaluated to discern how they facilitated comparison of the chemical composition of commercial green tea [Camellia sinensis (L.) Kuntze] products, with the goal of capturing the variability of commercially used products and selecting representative products for in vitro or clinical evaluation...
April 28, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28449490/transcutaneous-electrical-acupoint-stimulation-teas-ameliorates-chemotherapy-induced-bone-marrow-suppression-in-lung-cancer-patients
#7
Lili Hou, Fen Gu, Guanghui Gao, Caicun Zhou
BACKGROUND: To investigate the effect of percutaneous electrical stimulation on chemotherapy-induced bone marrow suppression in patients with lung cancer. METHODS: From December 2014 to August 2015, one hundred ninety-one non-small cell lung cancer patients with chemotherapy naive were randomly divided into control group, medication group, and transcutaneous electrical acupoint stimulation (TEAS) group. Patients with the control group received routine nursing care, the medication group was treated by oral administration of prophylactic agents, and TEAS group received electrical stimulation of acupoints including Dazhui (DU14), Geshu (BL17), Zusanli (ST36), Sanyinjiao (SP6), and Hegu (LI4)...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448076/tea-consumption-and-health-related-quality-of-life-in-older-adults
#8
C-W Pan, Q Ma, H-P Sun, Y Xu, N Luo, P Wang
BACKGROUND: Although tea consumption has been reported to have various health benefits in humans, its association with health-related quality of life (HRQOL) has not been investigated directly. We aimed to examine the relationship between tea consumption and HRQOL among older Chinese adults. METHODS: We analyzed community-based cross-sectional data of 5,557 older Chinese individuals aged 60 years or older who participated in the Weitang Geriatric Diseases study...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28447311/attenuation-of-glutamate-induced-excitotoxicity-by-withanolide-a-in-neuron-like-cells-role-for-pi3k-akt-mapk-signaling-pathway
#9
Nawab John Dar, Naresh Kumar Satti, Prabhu Dutt, Abid Hamid, Muzamil Ahmad
Glutamate-induced excitotoxicity is one of the major underlying mechanisms for neurodegenerative diseases. Efforts are being made to treat such conditions with an array of natural compounds that can modulate the release of glutamate or the underlying mechanisms associated with it. Withania somnifera extract has potent pharmacologic activity similar to that of Korean Ginseng tea and is used to treat several neuronal disorders. However, to date, little efforts have been made to evaluate individual constituents of this plant for neurodegenerative disorders...
April 26, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28445814/comprehensive-profiling-and-characterization-of-coumarins-from-roots-stems-leaves-branches-and-seeds-of-chimonanthus-nitensoliv-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-combined-with-modified-mass-defect-filter
#10
Ting Tan, Yun Luo, Chen-Cong Zhong, Xu Xu, Yulin Feng
Chimonanthus nitensOliv. (CNO), having been studied and developed as the tea beverages, tea raw materials and preparations, an unique species in China, have been extensively used for treating colds and influenza for centuries. In the present study, a method based on the modified mass defect filter (MDF) was firstly developed and validated for comprehensive profiling of coumarins in the different parts of CNO via ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS)...
April 17, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28445390/prevention-of-colorectal-cancer-by-targeting-obesity-related-disorders-and-inflammation
#11
REVIEW
Yohei Shirakami, Masaya Ohnishi, Hiroyasu Sakai, Takuji Tanaka, Masahito Shimizu
Colorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in the prevention of this disease. Chronic inflammation in colonic mucosa and obesity, and its related metabolic abnormalities, are considered to increase the risk of colorectal cancer. Therefore, treatments targeting these factors might be a promising strategy to prevent the development of colorectal cancer. Among a number of functional foods, various phytochemicals, including tea catechins, which have anti-inflammatory and anti-obesity properties, and medicinal agents that ameliorate metabolic disorders, might also be beneficial in the prevention of colorectal cancer...
April 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28445129/tea-consumption-and-the-risk-of-ovarian-cancer-a-meta-analysis-of-epidemiological-studies
#12
Xin Zhan, Jie Wang, Shufen Pan, Caijuan Lu
A large number of epidemiological studies have provided conflicting results about the relationship between tea consumption and ovarian cancer. This study aimed to clarify the association between tea consumption and ovarian cancer. A literature search of the MEDICINE, Scopus, PubMed, and Web of Science databases was performed in April 2016. A total of 18 (11 case-control and 7 cohort) studies, representing data for 701,857 female subjects including 8,683 ovarian cancer cases, were included in the meta-analysis...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28442715/work-disability-before-and-after-a-major-cardiovascular-event-a-ten-year-study-using-nationwide-medical-and-insurance-registers
#13
Marianna Virtanen, Jenni Ervasti, Ellenor Mittendorfer-Rutz, Tea Lallukka, Linnea Kjeldgård, Emilie Friberg, Mika Kivimäki, Erik Lundström, Kristina Alexanderson
We examined the trajectories of work disability before and after IHD and stroke events. New IHD (n = 13521) and stroke (n = 7162) cases in 2006-2008 were retrieved from nationwide Swedish hospital records and their annual work disability days five years before and after the date of diagnosis were retrieved from a nationwide disability register. There was no pre-event differences in disability days between the IHD and stroke cases and five years prior to the event, they were close to those observed in the general population...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28441777/health-effects-of-psidium-guajava-l-leaves-an-overview-of-the-last-decade
#14
REVIEW
Elixabet Díaz-de-Cerio, Vito Verardo, Ana María Gómez-Caravaca, Alberto Fernández-Gutiérrez, Antonio Segura-Carretero
Today, there is increasing interest in discovering new bioactive compounds derived from ethnomedicine. Preparations of guava (Psidium guajava L.) leaves have traditionally been used to manage several diseases. The pharmacological research in vitro as well as in vivo has been widely used to demonstrate the potential of the extracts from the leaves for the co-treatment of different ailments with high prevalence worldwide, upholding the traditional medicine in cases such as diabetes mellitus, cardiovascular diseases, cancer, and parasitic infections...
April 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28441610/total-esterase-measurement-in-saliva-of-pigs-validation-of-an-automated-assay-characterization-and-changes-in-stress-and-disease-conditions
#15
Fernando Tecles, María D Contreras-Aguilar, Silvia Martínez-Miró, Asta Tvarijonaviciute, Silvia Martínez-Subiela, Damián Escribano, José J Cerón
An automated spectrophotometric method for total esterase activity (TEA) measurement in porcine saliva has been developed and validated, using 4-nitrophenyl acetate (4-NA) as substrate. The method was precise and accurate, with low limit of detection, and was able to measure samples with TEA activities up to 400IU/L without any dilution. In addition, the different enzymes contributing to TEA were characterized, being identified carbonic anhydrase VI (CA-VI), lipase, cholinesterase (ChE) and cholesterol esterase (CEL)...
April 18, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28440509/modulation-of-mmp-2-and-9-secretion-by-cytokines-inducers-and-inhibitors-in-human-melanoma-a-2058-cells
#16
M Waheed Roomi, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias Rath
Melanoma, an extremely aggressive cancer, causes the most skin cancer-related deaths, due to metastasis to other areas of the body, such as lymph nodes, lungs, liver, brain or bone. It is characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the extracellular matrix and basement membrane, allowing cancer cells to spread to distal organs. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activities. We investigated the roles of these in regulation of MMP-2 and -9 in human melanoma A-2058 cells...
April 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28440064/synthetic-and-analytical-strategies-for-the-quantification-of-phenyl-%C3%AE-valerolactone-conjugated-metabolites-in-human-urine
#17
Nicoletta Brindani, Pedro Mena, Luca Calani, Iris Benzie, Siu-Wai Choi, Furio Brighenti, Franca Zanardi, Claudio Curti, Daniele Del Rio
SCOPE: The contribution of the gut microbiota to the metabolism of catechins and proanthocyanidins remains unclear. Phenyl-γ-valerolactones have been identified as the most representative metabolites of these dietary flavan-3-ols, but their accurate quantification has posed problems because of a lack of appropriate bioanalytical standards. This work aimed at synthesizing a novel set of sulphate- and glucuronide-conjugated phenyl-γ-valerolactones and at developing an analytical platform using UHPLC-ESI-MS/MS for their quantification in urine...
April 25, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28439281/l-theanine-content-and-related-gene-expression-novel-insights-into-theanine-biosynthesis-and-hydrolysis-among-different-tea-plant-camellia-sinensis-l-tissues-and-cultivars
#18
Zhi-Wei Liu, Zhi-Jun Wu, Hui Li, Yong-Xin Wang, Jing Zhuang
L-Theanine content has tissues and cultivars specificity in tea plant (Camellia sinensis L.), the correlations of theanine metabolic related genes expression profiles with theanine contents were explored in this study. L-theanine contents in the bud and 1st leaf, 2nd leaf, 3rd leaf, old leaf, stem, and lateral root were determined by HPLC from three C. sinensis cultivars, namely 'Huangjinya', 'Anjibaicha', and 'Yingshuang', respectively. The theanine contents in leaves and root of 'Huangjinya' were the highest, followed by 'Anjibaicha', and 'Yingshuang'...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28436611/co-ingestion-of-willow-bark-tea-and-acetaminophen-associated-with-fatal-infantile-fulminant-liver-failure
#19
Deepak Dinakaran, Erin Bristow, Hanan Armanious, Daniel Garros, Jason Yap, Michelle Noga, Consolato Sergi
No abstract text is available yet for this article.
April 24, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28435822/targeted-intracellular-heat-transfer-in-cancer-therapy-assessment-of-asparagine-laminated-gold-nanoparticles-in-cell-model-of-t-cell-leukemia
#20
Shadab Shahriari, Maryam Bakhshi, Ahmad Reza Shahverdi, Azar Berahmeh, Farnaz Safavifar, Mohammad Reza Khorramizadeh
BACKGROUND: High temperatures have destructive effects on cancer cells by damaging proteins and structures within cells. Gold nanoparticles (AuNPs) can act as drug delivery vehicles, especially for cancer therapy. Due to the selective intake of asparagine molecules into malignant cells, AuNPs were coated with asparagine; and CCRF-CEM human T-cell leukemia cells were treated with the new combination, Asn-AuNPs, at 39 °C. METHODS: The co-authors from a number of collaborative labs located at Tehran University of Medical Sciences, Tehran, Iran, have initiated the idea and preliminary design of this study in 2011...
March 2017: Iranian Journal of Public Health
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