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https://www.readbyqxmd.com/read/29679944/epigallocatechin-3-gallate-attenuates-microcystin-lr-induced-apoptosis-in-human-umbilical-vein-endothelial-cells-through-activation-of-the-nrf2-ho-1-pathway
#1
Jun Shi, Min Zhang, Libin Zhang, Huipin Deng
Our previous study showed that the tea extract, epigallocatechin-3-gallate (EGCG), protects against microcystin-LR (MC-LR) -mediated apoptosis of human umbilical vein endothelial cells (HUVECs); however, the mechanism underlying MC-LR-induced HUVEC apoptosis remains incompletely understood. In this study, we investigated whether the nuclear factor erythroid-like 2 (NRF2)/heme oxygenase-1 (HO-1) pathway, which regulates antioxidant transcriptional regulation of oxidative stress and apoptosis, is involved in this process...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679905/qing-brick-tea-qbt-aqueous-extract-protects-monosodium-glutamate-induced-obese-mice-against-metabolic-syndrome-and-involves-up-regulation-transcription-factor-nuclear-factor-erythroid-2-related-factor-2-nrf2-antioxidant-pathway
#2
Wenqi Gao, Changyi Xiao, Jun Hu, Biaoxin Chen, Chunyan Wang, Bangping Cui, Pengyi Deng, Jian Yang, Zhifang Deng
BACKGROUND: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is an important post-fermentation dark tea. Our present study was performed to investigate the ameliorative effects of QBT aqueous extract on metabolic syndrome (Mets) in monosodium glutamate-induced obese mice and the potential mechanisms. METHOD: Monosodium glutamate-induced obese mice were used to evaluate the anti-Mets effects of QBT. Content levels of malonaldehyde (MDA), reactive oxygen species (ROS) and protein carbonylation, antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR) in the skeletal muscle were assessed by commercial kits, respectively...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679540/the-free-energy-of-biomembrane-and-nerve-excitation-and-the-role-of-anesthetics
#3
Tian Wang, Tea Mužić, Andrew D Jackson, Thomas Heimburg
In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference necessary to induce a phase transition in the nerve membrane. It is a function of temperature and pressure, and it is sensitively dependent on the presence of anesthetics which lower melting transitions. We investigate the free energy difference of solid and liquid membrane phases under the influence of anesthetics...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29678829/draft-genome-sequence-of-camellia-sinensis-var-sinensis-provides-insights-into-the-evolution-of-the-tea-genome-and-tea-quality
#4
Chaoling Wei, Hua Yang, Songbo Wang, Jian Zhao, Chun Liu, Liping Gao, Enhua Xia, Ying Lu, Yuling Tai, Guangbiao She, Jun Sun, Haisheng Cao, Wei Tong, Qiang Gao, Yeyun Li, Weiwei Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, Congbing Fang, Yi Yue, Fangdong Li, Daxiang Li, Shu Wei, Bin Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Jeffrey L Bennetzen, Shancen Zhao, Xiaochun Wan
Tea, one of the world's most important beverage crops, provides numerous secondary metabolites that account for its rich taste and health benefits. Here we present a high-quality sequence of the genome of tea, Camellia sinensis var. sinensis (CSS), using both Illumina and PacBio sequencing technologies. At least 64% of the 3.1-Gb genome assembly consists of repetitive sequences, and the rest yields 33,932 high-confidence predictions of encoded proteins. Divergence between two major lineages, CSS and Camellia sinensis var...
April 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29677711/electrical-characteristics-of-ge-si-based-source-pocket-tunnel-field-effect-transistors
#5
Tea Jun Ahn, Yun Seop Yu
Two types of Ge/Si-based novel tunnel field-effect transistors (TFETs) with source pockets are proposed. In the proposed Ge/Si-based TFETs, the materials in the source, channel, and drain are Ge, Si, and Si, respectively, and the gate shortly overlaps the source. One of the proposed TFETs has an intrinsic Ge pocket and the other has an intrinsic Si pocket, shallowly doped in the source region below the source-overlapped gate. The current-voltage (I-V) characteristics of the proposed Ge/Si-based TFETs were simulated using the TCAD device simulator, and were compared with those of Si, Ge, and Ge (in source)/Si (in channel and drain) TFETs...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677167/the-role-of-catechins-in-cellular-responses-to-oxidative-stress
#6
REVIEW
Jurga Bernatoniene, Dalia Marija Kopustinskiene
Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29676959/correction-to-enhanced-osteogenic-behavior-of-adscs-produced-by-deproteinized-antler-cancellous-bone-and-evidence-for-involvement-of-erk-signaling-pathway-by-wei-j-xu-m-zhang-x-meng-s-wang-y-zhou-t-ma-q-han-b-wei-y-and-deng-x-tissue-eng-part-a-2015-21-11-12
#7
https://www.readbyqxmd.com/read/29676581/camellimidazole-a-c-three-methylene-bridged-dimeric-imidazole-alkaloids-from-keemun-black-tea
#8
Wei Wang, Xing Tang, Fang Hua, Tie-Jun Ling, Xiao-Chun Wan, Guan-Hu Bao
Three new dimeric imidazole alkaloids with a methylene bridge, camellimidazole A-C (1-3), were isolated from Keemum black tea. Their structures were completely elucidated by a combination of diverse spectroscopic and single-crystal X-ray diffraction analyses. The plausible formation pathway of camellimidazole A-C was proposed. Compounds 1 and 2 exhibited remarkable protection against H2 O2 -induced neuronal damage at the concentration of 1.0 μM.
April 20, 2018: Organic Letters
https://www.readbyqxmd.com/read/29675530/hepatoprotective-activity-of-iridoids-seco-iridoids-and-analog-glycosides-from-gentianaceae-on-hepg2-cells-via-cyp3a4-induction-and-mitochondrial-pathway
#9
Kang Dai, Xue-Jia Yi, Xian-Ju Huang, Azhar Muhammad, Mei Li, Jun Li, Guang-Zhong Yang, Yue Gao
Gentianaceae herb extracts have been widely used as food additives, teas or medicinal remedies for various diseases and disorders of the human body. Herein, the potential effects of iridoids, seco-iridoids and analog glycosides from gentian on acontine-induced hepatotoxicity were investigated in HepG2 cells to obtain metabolic data of drug-biotarget interactions. Molecular docking analysis was performed to assess the binding efficiencies of 53 iridoids, seco-iridoids and analog compounds obtained from 50 gentian species to the active sites of human CYP3A4 enzyme...
April 20, 2018: Food & Function
https://www.readbyqxmd.com/read/29674367/trends-in-diagnosis-specific-work-disability-before-and-after-ischaemic-heart-disease-a-nationwide-population-based-cohort-study-in-sweden
#10
Jenni Ervasti, Marianna Virtanen, Tea Lallukka, Emilie Friberg, Ellenor Mittendorfer-Rutz, Erik Lundström, Kristina Alexanderson
OBJECTIVES: We examined trends of diagnosis-specific work disability before and after ischaemic heart disease (IHD). DESIGN: Participants were followed 4 years before and 4 years after an IHD event for diagnosis-specific work disability (sickness absence and disability pension). SETTING AND PARTICIPANTS: A Swedish population-based cohort study using register data on all individuals aged 25-60 years, living in Sweden, and who suffered their first IHD event in 2006-2008 (n=23 971) was conducted...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674068/simultaneous-determination-of-theophylline-and-caffeine-on-novel-tetra-5-chloroquinolin-8-yloxy-phthalocyanato-manganese-iii-carbon-nanotubes-composite-electrode
#11
Çağrı Ceylan Koçak, Asiye Nas, Halit Kantekin, Zekerya Dursun
This work reports the synthesis of new symmetrically substituted manganese(III) phthalocyanine (2eOHMnPc) (2) containing tetra 5-chloroquinolin-8-yloxy group at the peripheral position for the first time. Manganese(III) phthalocyanine (2) was synthesized by cyclotetramerization of 4-(5-chloroquinolin-8-yloxy)phthalonitrile (1) in the presence of corresponding metal salt (manganese(II) chloride). This peripherally substituted phthalocyanine complex (2) was purified by column chromatography and characterized by several techniques such as IR, mass and UV-Visible spectral data...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29674021/solid-phase-microextraction-method-using-a-novel-polystyrene-oleic-acid-imidazole-polymer-in-micropipette-tip-of-syringe-system-for-speciation-and-determination-of-antimony-in-environmental-and-food-samples
#12
Abdul Haleem Panhwar, Mustafa Tuzen, Baki Hazer, Tasneem Gul Kazi
A simple, rapid and sensitive solid phase microextraction method was used for the speciation of inorganic antimony (Sb) by using a novel synthesized polymeric material in micropipette tip of syringe system. In present methodology, the specie of Sb (III) made hydrophobic complex with diethyl dithiocarbamate (DDTC) at pH 5.5 and subsequently adsorbed on polystyrene oleic acid imidazole polymer (POIP), whereas Sb(V) did not made complex and adsorbed on the polymer, remained in aqueous solutions. The strategy of multivariate was carried out to screen out the different variables and assessed the optimum values of their experimental values for the extraction efficiency of analyte...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29671790/chemical-synthesis-and-functional-analysis-of-varva-cyclotide
#13
Claudio A Álvarez, Paula A Santana, Omar Luna, Constanza Cárdenas, Fernando Albericio, María S Romero, Fanny Guzmán
Cyclotides are circular peptides found in various plant families. A cyclized backbone, together with multiple disulfide bonds, confers the peptides’ exceptional stability against protease digestion and thermal denaturation. In addition, the features of these antimicrobial molecules make them suitable for use in animal farming, such as aquaculture. Fmoc solid phase peptide synthesis on 2-chlorotrityl chlorine (CTC) resin using the “tea-bag” approach was conducted to generate the VarvA cyclotide identified previously from Viola arvensis ...
April 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29671630/the-critical-role-of-epigallocatechin-gallate-in-regulating-mitochondrial-metabolism
#14
Weimei Shi, Linfu Li, Yechun Ding, Kai Yang, Zhixi Chen, Xiaona Fan, Shan Jiang, Yingjie Guan, Zhiping Liu, Daohua Xu, Longhuo Wu
Epigallocatechin gallate (EGCG), one of polyphenols isolated from green tea, exhibits biology-benefiting effects with minimum severe adverse. EGCG is known to be a mitochondrion-targeting medicinal agent, regulating mitochondrial metabolism, including mitochondrial biogenesis, mitochondrial bioenergetics, and mitochondria-mediated cell cycle and apoptosis. EGCG might exhibit either antioxidative activity to prevent against oxidative stress or pro-oxidative activity to counteract cancer cells, which depends on the cellular stress situations, cell types and the concentration of EGCG...
April 19, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29671217/cyproheptadine-regulates-pyramidal-neuron-excitability-in-mouse-medial-prefrontal-cortex
#15
Yan-Lin He, Kai Wang, Qian-Ru Zhao, Yan-Ai Mei
Cyproheptadine (CPH), a first-generation antihistamine, enhances the delayed rectifier outward K+ current (IK ) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. In this study, we aimed to determine the effects of CPH on neuronal excitability in current-clamped pyramidal neurons in mouse medial prefrontal cortex slices. CPH (10 µmol/L) significantly reduced the current density required to generate action potentials (APs) and increased the instantaneous frequency evoked by a depolarizing current...
April 18, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29669412/novel-flavoalkaloids-from-white-tea-with-inhibitory-activity-against-formation-of-advanced-glycation-end-products
#16
Xiao Li, Guang-Jin Liu, Wei Zhang, Yv-Long Zhou, Tie-Jun Ling, Xiao-Chun Wan, Guan-Hu Bao
Two novel flavoalkaloids, (-)-6-(5'''S)-N-ethyl-2-pyrrolidinone-epigallocatechin -O-gallate (ester-type catechins pyrrolidinone A, etc-pyrrolidinone A, 1), (-)-6-(5'''R)-N-ethyl-2-pyrrolidinone-epigallocatechin-O-gallate (etc-pyrrolidinone B,2) and new naturally occurring flavoalkaloids (-)-8-N-ethyl-2-pyrrolidinone-epigallocatechin-O-gallate (etc-pyrrolidinone C,3a and etc- pyrrolidinone D,3b), were isolated from white tea (Camellia sinensis). Their structures were identified by extensive NMR spectra...
April 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29669325/characterization-of-the-%C3%AF-pore-in-mutant-hkv1-3-potassium-channels
#17
Pavel Tyutyaev, Stephan Grissmer
BACKGROUND/AIMS: The replacement of the amino acid valine at position 388 (Shaker position 438) in hKv1.3 channels or at the homologue position 370 in hKv1.2 channels resulted in a channel with two different ion conducting pathways: One pathway was the central, potassium-selective α-pore, that was sensitive to block by peptide toxins (CTX or KTX in the hKv1.3_V388C channel and CTX or MTX in the hKv1.2_V370C channel). The other pathway (σ-pore) was behind the central α-pore creating an inward current at potentials more negative than -100 mV, a potential range where the central α-pore was closed...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29668849/qualitative-and-quantitative-analyses-of-active-constituents-in-trollius-ledebourii
#18
Man Liao, Xiaoye Cheng, Xia Zhang, Xinpeng Diao, Caijuan Liang, Lantong Zhang
Trollius ledebourii has been more involved in Mongolian medicine and is often used as a type of tea for heat-clearing and detoxifying in the populus. In this study, a rapid and sensitive method was established for the qualitative and quantitative analyses of the major constituents in T. ledebourii. Ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was developed for the identification of the multi-constituents in T. ledebourii. A total of 37 chemical constituents in T...
April 13, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29668397/phototherapy-with-led-shows-promising-results-in-healing-chronic-wounds-in-diabetes-mellitus-patients-a-prospective-randomized-double-blind-study
#19
Igor Frangež, Tea Nizič-Kos, Helena Ban Frangež
OBJECTIVE: The study examined the influence of phototherapy with light-emitting diodes (LEDs) on chronic diabetic wound healing. BACKGROUND: Chronic diabetic wounds are very difficult to treat due to underlying conditions such as angiopathy and neuropathy, resulting in slow healing rates. Conventional treatment options are often insufficient and do not provide satisfactory outcomes. Phototherapy with LED enhances the healing processes through mechanisms of energy exchange between incoming photons and their target, the main one being cytochrome-c oxidase in mitochondria...
April 18, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29668030/uv-c-irradiation-on-the-quality-of-green-tea-effect-on-catechins-antioxidant-activity-and-cytotoxicity
#20
Matthew J Vergne, Ankit Patras, Manreet S Bhullar, Lincoln M Shade, Michael Sasges, Kanyasiri Rakariyatham, Che Pan, Hang Xiao
Short-wavelength ultraviolet (UV-C) irradiation is a nonthermal processing technique that is a possible alternative to the heat-pasteurization of tea beverages. This study investigated the effect of UV-C irradiation on the polyphenolic and total phenolic contents of a green tea beverage and analyzed cytotoxicity of irradiated green tea using a novel continuous flow-through UV system. UV-C fluence levels ranging from 0 to 240 mJ/cm2 were delivered to green tea, and polyphenols were chemically profiled. Continuous-flow UV-C irradiation of the green tea beverage at a fluence of 68 mJ/cm2  induced a minor reduction in the concentration of the most abundant catechin in green tea, (-)-epigallocatechin gallate (EGCG), from 145 to 131...
April 18, 2018: Journal of Food Science
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