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https://www.readbyqxmd.com/read/29678503/caffeine-inhibits-stat1-signaling-and-downregulates-inflammatory-pathways-involved-in-autoimmunity
#1
Merve Iris, Pei-Suen Tsou, Amr H Sawalha
Caffeine is a widely consumed pharmacologically active product. We focused on characterizing immunomodulatory effects of caffeine on peripheral blood mononuclear cells. Caffeine at high doses showed a robust downregulatory effect on cytokine activity and genes related to several autoimmune diseases including lupus and rheumatoid arthritis. Dose-dependent validation experiments showed downregulation at the mRNA levels of key inflammatory genes including STAT1, TNF, and PPARG. TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee...
April 17, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29677345/pharmacokinetics-of-caffeine-in-the-lens-capsule-epithelium-after-peroral-intake-a-pilot-randomized-controlled-study
#2
Martin Kronschläger, Thomas Stimpfl, Manuel Ruiß, Nino Hirnschall, Christoph Leisser, Oliver Findl
Purpose: To determine the pharmacokinetics of perorally administered caffeine, a widely consumed and potent dietary antioxidant, in the anterior lens capsule and lens epithelial cells, a crucial cell monolayer for cataract development. Methods: Bilateral cataract patients were scheduled for cataract surgery with a caffeine abstinence of 1 week before surgery of each eye. At the day of surgery of the second eye patients were administered no drink (0-mg group) or coffee with 60-, 120-, or 180-mg caffeine...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29674877/a-new-species-of-knob-scaled-lizard-xenosauridae-xenosaurus-from-the-sierra-madre-oriental-of-puebla-mexico
#3
Adrián Nieto-Montes de Oca, Helder Sánchez-Vega, Itzel Durán-Fuentes
A new species of Xenosaurus in the X. tzacualtipantecus clade is described from the Sierra Madre Oriental of northern Puebla, Mexico. The new species differs from all of its congeners in possessing a unique combination of characters. The new species appears to be allopatric and fills in the geographic gap between the geographic distributions of X. tzacualtipantecus and the species in the newmanorum clade to the north and northwest and those of the species in the grandis and rackhami clades to the south and southeast...
2018: ZooKeys
https://www.readbyqxmd.com/read/29674606/hirschsprung-s-disease-related-giant-sigmoid-volvulus-complicated-by-refractory-hypertension-in-an-elderly-man
#4
Shaohan Wu, Xiaofang Sun, Yawei Yu, Yiyu Shen
BACKGROUND Sigmoid volvulus (SV) is a life-threatening condition occasionally seen in adults. Adult Hirschsprung's disease (HD)-related SV is rarely complicated by difficult-to-control hypertension. In this report we present the case of an elderly man with a rare constellation of HD, SV, and refractory hypertension. CASE REPORT An 82-year-old man had long-term constipation, moderate abdominal pain, and progressive abdominal distension. A CT scan revealed the typical "coffee bean sign". Blood pressure was abnormal high...
April 20, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29673632/exfoliative-esophagitis-caused-by-habitual-ingestion-of-very-hot-coffee
#5
Florian Schertl, Björn Lewerenz, Wolfgang Schepp
No abstract text is available yet for this article.
April 16, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29671781/development-of-noninvasive-classification-methods-for-different-roasting-degrees-of-coffee-beans-using-hyperspectral-imaging
#6
Bingquan Chu, Keqiang Yu, Yanru Zhao, Yong He
This study aimed to develop an approach for quickly and noninvasively differentiating the roasting degrees of coffee beans using hyperspectral imaging (HSI). The qualitative properties of seven roasting degrees of coffee beans (unroasted, light, moderately light, light medium, medium, moderately dark, and dark) were assayed, including moisture, crude fat, trigonelline, chlorogenic acid, and caffeine contents. These properties were influenced greatly by the respective roasting degree. Their hyperspectral images (874⁻1734 nm) were collected using a hyperspectral reflectance imaging system...
April 19, 2018: Sensors
https://www.readbyqxmd.com/read/29671616/a-parallel-multiobjective-metaheuristic-for-multiple-sequence-alignment
#7
Álvaro Rubio-Largo, Mauro Castelli, Leonardo Vanneschi, Miguel A Vega-Rodríguez
The alignment among three or more nucleotides/amino acids sequences at the same time is known as multiple sequence alignment (MSA), a nondeterministic polynomial time (NP)-hard optimization problem. The time complexity of finding an optimal alignment raises exponentially when the number of sequences to align increases. In this work, we deal with a multiobjective version of the MSA problem wherein the goal is to simultaneously optimize the accuracy and conservation of the alignment. A parallel version of the hybrid multiobjective memetic metaheuristics for MSA is proposed...
April 19, 2018: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29669426/do-coffee-farmers-benefit-in-food-security-from-participating-in-coffee-cooperatives-evidence-from-southwest-ethiopia-coffee-cooperatives
#8
Zekarias Shumeta, Marijke D'Haese
BACKGROUND: Most coffee in Ethiopia is produced by smallholder farmers who face a daily struggle to get sufficient income but also to feed their families. At the same time, many smallholder coffee producers are members of cooperatives. Yet, literature has paid little attention to the effect of cooperatives on combating food insecurity among cash crop producers including coffee farmers. OBJECTIVE: The objective of the study was to investigate how coffee cooperative membership may affect food security among coffee farm households in Southwest Ethiopia...
January 1, 2018: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/29668379/predictability-force-and-anti-resonance-in-complex-object-control
#9
Pauline Maurice, Neville Hogan, Dagmar Sternad
Manipulation of complex objects as in tool use is ubiquitous and has given humans an evolutionary advantage. This study examined the strategies humans choose when manipulating an object with underactuated internal dynamics, such as a cup of coffee. The object's dynamics renders the temporal evolution complex, possibly even chaotic, and difficult to predict. A cart-and-pendulum model, loosely mimicking coffee sloshing in a cup, was implemented in a virtual environment with a haptic interface. Participants rhythmically manipulated the virtual cup containing a rolling ball; they could choose the oscillation frequency, while the amplitude was prescribed...
April 18, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29666454/long-term-coffee-monoculture-alters-soil-chemical-properties-and-microbial-communities
#10
Qingyun Zhao, Wu Xiong, Yizhang Xing, Yan Sun, Xingjun Lin, Yunping Dong
Long-term monoculture severely inhibits coffee plant growth, decreases its yield and results in serious economic losses in China. Here, we selected four replanted coffee fields with 4, 18, 26 and 57 years of monoculture history in Hainan China to investigate the influence of continuous cropping on soil chemical properties and microbial communities. Results showed long-term monoculture decreased soil pH and organic matter content and increased soil EC. Soil bacterial and fungal richness decreased with continuous coffee cropping...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663530/geographical-evaluation-of-neuroparacoccidioidomycosis-and-paracoccidioidomycosis-in-southern-brazil
#11
Sergio Monteiro de Almeida, Gabriel L O Salvador, Thiago Henrique Roza, Luís Felipe Izycki, Isaias Dos Santos, Afonso Aragão, Amanda Kulik, Marisol Muro, Luis Fernando Bleggi Torres, Lucia Helena de Noronha
BACKGROUND: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis among immunocompetent patients in Latin America. OBJECTIVE: This study aimed to describe the expansion over time and the geographical distribution of confirmed Neuroparacoccidioidomycosis (NPCM) and PCM cases, and relate it to environmental characteristics such as climate, soil types, and coffee crops. METHODS: This was a retrospective study of autopsy and biopsy reports between 1951 and 2014 from the Medical Pathology Section of the Hospital de Clinicas, UFPR, Curitiba, Southern Brazil...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29662650/hdl-and-associated-factors-stratified-by-sex-and-menopausal-status-results-from-a-community-based-survey-in-taiwan
#12
Huan-Cheng Chang, Chuan-Fa Hsieh, Disline Manli Tantoh, Pei-Chieh Ko, Ya-Yu Kung, Mei-Chi Lin, Yi-Ching Liaw, Yung-Po Liaw
Aim: To investigate factors, especially modifiable factors associated with high-density lipoprotein (HDL) in Taiwanese based on sex and menopausal status. Materials and Methods: Participants comprised 2022 men and 2392 women (1267 menopausal and 1125 non-menopausal) aged ≥30 years who resided in Pingzhen district, Taoyuan from 2006-2011. Their data, obtained through questionnaires and measurements were retrieved from the Li-Shin Hospital. Results: Higher HDL was associated with total cholesterol, underweight, and alcohol drinking in both men and women...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661311/isolation-and-characterisation-of-microcrystalline-cellulose-and-cellulose-nanocrystals-from-coffee-husk-and-comparative-study-with-rice-husk
#13
Sofía Collazo-Bigliardi, Rodrigo Ortega-Toro, Amparo Chiralt Boix
Cellulosic material from coffee husk has not been previously studied despite being a potential source of reinforcing agents for different applications. This material has been extracted and characterised from coffee husk, in parallel with previously studied rice husk. Samples have been analysed as to their ability to obtain cellulosic fibres and cellulose nanocrystals (CNC) by applying alkali and bleaching treatments and final sulphuric acid hydrolysis. Microstructural changes were analysed after treatments, and the size and aspect ratio of CNCs were determined...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29660426/coffee-and-tea-drinking-in-relation-to-risk-of-hip-fracture-in-the-singapore-chinese-health-study
#14
Zhaoli Dai, Aizhen Jin, Avril Zixin Soh, Li-Wei Ang, Jian-Min Yuan, Woon-Puay Koh
Meta-analyses of studies conducted among Western populations suggest that coffee consumption does not affect osteoporotic fracture risk. However, experimental studies have shown that the effect of caffeine on bone health may depend on dosage. We examined the associations between consumption of coffee, tea and caffeine and risk of hip fracture in an Asian cohort. In a population-based prospective cohort of 63,257 Chinese men and women aged 45-74 years in Singapore, a validated semi-quantitative food frequency questionnaire was used to assess habitual consumption of coffee and tea at baseline...
April 13, 2018: Bone
https://www.readbyqxmd.com/read/29659697/variations-in-leaf-growth-parameters-within-the-tree-structure-of-adult-coffea-arabica-in-relation-to-seasonal-growth-water-availability-and-air-carbon-dioxide-concentration
#15
Miroslava Rakocevic, Fabio Takeshi Matsunaga
Background and Aims: Dynamics in branch and leaf growth parameters, such as the phyllochron, duration of leaf expansion, leaf life span and bud mortality, determine tree architecture and canopy foliage distribution. We aimed to estimate leaf growth parameters in adult Arabica coffee plants based on leaf supporter axis order and position along the vertical profile, considering their modifications related to seasonal growth, air [CO2] and water availability. Methods: Growth and mortality of leaves and terminal buds of adult Arabica coffee trees were followed in two independent field experiments in two sub-tropical climate regions of Brazil, Londrina-PR (Cfa) and Jaguariúna-SP (Cwa)...
April 5, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29659178/a-prospective-randomized-double-blind-two-period-crossover-pharmacokinetic-trial-comparing-green-coffee-bean-extract-a-botanically-sourced-caffeine-with-a-synthetic-usp-control
#16
Kayce Morton, Katelin Knight, Douglas Kalman, Susan Hewlings
Coffee is a primary dietary source of the chlorogenic acids (CGAs) of phenolic compounds. Coffee contains caffeine and other phytonutrients, including CGAs. Caffeine on its own has been well characterized and descried pharmacokinetically in the literature, less so for CGAs. The purpose of this double-blind crossover study was to determine the comparative pharmacokinetics of CGAs with caffeine (natural extract) with synthetic caffeine (US Pharmacopeia [USP] standard). Sixteen healthy male subjects were randomly assigned to take 1 dose of product 1, 60 mg of botanically sourced caffeine from 480 mg of green coffee bean extract, or product 2, 60 mg of synthetic USP caffeine, with 5 days between...
April 16, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29658406/designing-a-neurofeedback-device-to-quantify-the-attention-levels-using-coffee-as-a-reward-system
#17
Kok Suen Cheng, Jun Xiang Lee, Poh Foong Lee
PURPOSE: Work performance is closely related to one's attention level. In this study, brain computer interface device that suitable for office usage was chosen to quantify the individual's attention levels. MATERIALS AND METHODS:  A brain-computer interface (BCI) system was adopted to interface brainwave signals to a coffee maker via three ascending levels of laser detectors. The preliminary test with this prototype was to characterize the attention level through the collected coffee amount...
April 16, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29657525/effect-of-different-surface-finishing-polishing-procedures-on-color-stability-of-esthetic-restorative-materials-a-spectrophotometric-evaluation
#18
Riccardo Beltrami, Matteo Ceci, Gabriele De Pani, Lodovico Vialba, Ricaldone Federico, Claudio Poggio, Marco Colombo
Objective: To evaluate the color stability of different esthetic restorative materials after surface finishing/polishing with different procedures. Materials and Methods: All materials were polymerized into silicone rubber rings to obtain specimens identical in size. Samples were randomly assigned into four groups (10 specimens of each composite for each group), and they were finished with different procedures: Control group (Group 1), three or two polishers interspersed with diamond grit (Groups 3 and 2, respectively), and one tungsten carbide bur + one polisher interspersed with diamond grit (Group 4)...
January 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29656646/towards-a-new-brewing-control-chart-for-the-21st-century
#19
John Melrose, Borja Roman-Corrochano, Marcela Montoya-Guerra, Serafim Bakalis
This paper describes new results from a base model of brewing from a bed of packed coffee grains. The model solves for the diffusion of soluble species out of a distribution of particles into the flow through the bed pore space. It requires a limited set of input parameters. It gives a simple picture of the basics physics of coffee brewing and sets out a set of reduced variables for this process. The importance of bed extraction efficiency is elucidated. A coffee brewing control chart has been widely used to describe the region of ideal coffee brewing for some 50 years...
April 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29656059/caffeic-acid-inhibits-hcv-replication-via-induction-of-ifn%C3%AE-antiviral-response-through-p62-mediated-keap1-nrf2-signaling-pathway
#20
Jian Shen, Guifeng Wang, Jianping Zuo
Hepatitis C virus (HCV) infection and its related liver disease have constituted a heavy burden worldwide. It had been reported that Drinking coffee could decrease mortality risk of HCV infected patients. Caffeic Acid (CA), the Coffee-related organic acid could inhibit HCV replication, however, the detailed mechanism of CA against HCV is unclear. In this study, we showed that CA could notably inhibit HCV replication. Mechanism study demonstrated that CA could induce HO-1 expression, which would trigger the IFNα antiviral response, and the antiviral effect of CA was attenuated when HO-1 activity was inhibited by SnPP (an HO-1 inhibitor)...
April 12, 2018: Antiviral Research
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