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https://www.readbyqxmd.com/read/29346438/colonization-of-the-cervicovaginal-space-with-gardnerella-vaginalis-leads-to-local-inflammation-and-cervical-remodeling-in-pregnant-mice
#1
Luz-Jeannette Sierra, Amy G Brown, Guillermo O Barilá, Lauren Anton, Carrie E Barnum, Snehal S Shetye, Louis J Soslowsky, Michal A Elovitz
The role of the cervicovaginal (CV) microbiome in regulating cervical function during pregnancy is poorly understood. Gardnerella vaginalis (G. vaginalis) is the most common bacteria associated with the diagnosis of bacterial vaginosis (BV). While BV has been associated with preterm birth (PTB), clinical trials targeting BV do not decrease PTB rates. It remains unknown if G. vaginalis is capable of triggering molecular, biomechanical and cellular events that could lead to PTB. The objective of this study was to determine if cervicovaginal colonization with G...
2018: PloS One
https://www.readbyqxmd.com/read/29342269/a-silent-epidemic-the-prevalence-incidence-and-persistence-of-mycoplasma-genitalium-among-young-asymptomatic-high-risk-women-in-the-united-states
#2
Arlene C Seña, Jeannette Y Lee, Jane Schwebke, Susan S Philip, Harold C Wiesenfeld, Anne M Rompalo, Robert L Cook, Marcia M Hobbs
Background: Mycoplasma genitalium (MG) is a sexually transmitted infection (STI) that can result in pelvic inflammatory disease and adverse pregnancy outcomes. We analyzed data collected from a prospective study of asymptomatic bacterial vaginosis (BV) to determine the natural history of MG. Methods: Women aged 15-25 years, with ≥2 STI risk factors and asymptomatic BV were recruited from 10 sites throughout the United States. Vaginal swabs were collected at enrollment, and by home-based testing every 2 months over 12 months...
January 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29339821/cigarette-smoking-is-associated-with-an-altered-vaginal-tract-metabolomic-profile
#3
T M Nelson, J C Borgogna, R D Michalek, D W Roberts, J M Rath, E D Glover, J Ravel, M D Shardell, C J Yeoman, R M Brotman
Cigarette smoking has been associated with both the diagnosis of bacterial vaginosis (BV) and a vaginal microbiota lacking protective Lactobacillus spp. As the mechanism linking smoking with vaginal microbiota and BV is unclear, we sought to compare the vaginal metabolomes of smokers and non-smokers (17 smokers/19 non-smokers). Metabolomic profiles were determined by gas and liquid chromatography mass spectrometry in a cross-sectional study. Analysis of the 16S rRNA gene populations revealed samples clustered into three community state types (CSTs) ---- CST-I (L...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334545/bacterial-vaginosis-modifies-the-association-between-hormonal-contraception-and-hiv-acquisition
#4
Lisa Haddad, Kristin M Wall, William Kilembe, Bellington Vwailika, Naw Htee, Ilene Brill, Elwyn Chomba, Amanda Tichacek, Susan Allen
OBJECTIVE: To examine BV as an effect modifier for the association between hormonal contraception (HC) and incident HIV infection DESIGN:: Serodiscordant couples enrolled in an open longitudinal cohort in Lusaka, Zambia from 1994-2012. This analysis was restricted to couples with an HIV-positive man enrolled between1994-2002 when a quarterly genital tract examination and HIV testing was performed. METHODS: Multivariate Cox models evaluated the association between contraceptive method and HIV-acquisition, stratified by time-varying BV status...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29327947/secnidazole-next-generation-antimicrobial-agent-for-bacterial-vaginosis-treatment
#5
Paul Nyirjesy, Jane R Schwebke
Secnidazole is a next-generation 5-nitroimidazole approved for more than three decades in Europe, Asia, South America and Africa and recently in the USA as a single-dose (2 g) treatment of bacterial vaginosis (BV). Secnidazole is characterized by potent in vitro antimicrobial activity against BV-associated pathogens, as well as prolonged terminal elimination half-life and systemic exposure. These characteristics form the basis of effective and safe treatment of BV with a 2-g single-dose secnidazole regimen, which was recently confirmed in double-blind, placebo-controlled clinical trials conducted in the USA...
January 12, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29324569/does-the-vaginal-flora-modify-when-a-synthetic-mesh-is-used-for-genital-prolapse-repair-in-postmenopausal-women-a-pilot-randomized-controlled-study
#6
Edilson Benedito de Castro, Luiz Gustavo Oliveria Brito, Paulo César Giraldo, Cássia Raquel Teatin Juliato
OBJECTIVE: The vaginal flora from postmenopausal women with pelvic organ prolapse (POP) is different from younger women. We hypothesized that the decision of a surgical route using a mesh would modify the vaginal flora. The purpose of this study was to analyze the vaginal flora from postmenopausal women that were submitted to abdominal sacrocervicopexy or vaginal sacrospinous fixation. METHODS: A pilot, randomized controlled study with 50 women aged 55 to 75 years (n = 25; abdominal sacrocervicopexy + subtotal hysterectomy; n = 25 vaginal sacrospinous fixation + vaginal hysterectomy) was performed...
January 10, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29323627/a-phase-3-multicenter-prospective-open-label-study-to-evaluate-the-safety-of-a-single-dose-of-secnidazole-2%C3%A2-g-for-the-treatment-of-women-and-postmenarchal-adolescent-girls-with-bacterial-vaginosis
#7
Steven E Chavoustie, Janet K Gersten, Milroy J Samuel, Jane R Schwebke
BACKGROUND: A novel formulation of secnidazole is under development in the United States for the treatment of bacterial vaginosis (BV). Efficacy and safety of other formulations of secnidazole have been reported. The objective of this study is to evaluate the safety of a single-dose oral granule formulation of secnidazole in a U.S. population of women with BV. METHODS: In this open-label study, patients were enrolled based on the following criteria: off-white, thin, homogeneous vaginal discharge; vaginal pH ≥4...
January 11, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29323559/reply-to-letter-to-editor-regarding-risk-of-bacterial-vaginosis-trichomonas-vaginalis-and-candida-albicans-infection-among-new-users-of-combined-hormonal-contraception-compared-to-levonorgestrel-releasing-intrauterine-system
#8
Mohamed Rezk, Tarek Sayyed, Alaa Masood, Ragab Dawood
No abstract text is available yet for this article.
January 11, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29305501/lactobacillus-deficient-vaginal-microbiota-dominate-post-partum-women-in-rural-malawi
#9
Ronan Doyle, Austridia Gondwe, Yue-Mei Fan, Kenneth Maleta, Per Ashorn, Nigel Klein, Kathryn Harris
The bacterial community found in the vagina is an important determinant of a woman's health and disease. A healthy vaginal microbiota is associated with a lower species richness and high proportions of one of a number of different Lactobacillus spp.. When disrupted the resulting abnormal vaginal microbiota is associated with a number of disease states and poor pregnancy outcomes. Studies up until now have concentrated on relatively small numbers of American and European populations which may not capture the full complexity of the community, nor adequately predict what constitutes a healthy microbiota in all populations...
January 5, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29304768/long-term-lactobacillus-rhamnosus-bmx-54-application-to-restore-a-balanced-vaginal-ecosystem-a-promising-solution-against-hpv-infection
#10
Ettore Palma, Nadia Recine, Lavinia Domenici, Margherita Giorgini, Alessandra Pierangeli, Pierluigi Benedetti Panici
BACKGROUND: Over recent years, a growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillus and other bacteria species in order to promote women's well-being. The aim of our study was to confirm that vaginal Lactobacilli long-lasting implementation in women with HPV-infections and concomitant bacterial vaginosis or vaginitis might be able to help in solving the viral infection, by re-establishing the original eubiosis. METHODS: A total of 117 women affected by bacterial vaginosis or vaginitis with concomitant HPV-infections were enrolled at Department of Gynecological Obstetrics and Urological Sciences, La Sapienza University, Rome, Italy between February 2015 and March 2016...
January 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29302531/need-for-revisiting-the-role-of-sexually-transmitted-disease-clinics-in-government-hospitals-in-india
#11
Madhulekha Bhattacharya, Hema Gogia
Introduction: The Government of India provides treatment for sexually transmitted infections (STIs) through government's sexually transmitted disease (STD) clinics with the mandate of providing curative and preventive services for clients in the context of STIs. However, besides the patients suffering from STDs, other clients with problems related to reproductive and sexual health also attend these clinics. This study aimed to assess the profile and treatment-seeking behavior of clients attending STD clinics in government hospitals in India...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29286178/toll-like-receptor-variants-and-cervical-atopobium-vaginae-infection-in-women-with-pelvic-inflammatory-disease
#12
Brandie D Taylor, Patricia A Totten, Sabina G Astete, Michael J Ferris, David H Martin, Roberta B Ness, Catherine L Haggerty
PROBLEM: Toll-like (TLR) receptor genetic variants have been implicated in bacterial vaginosis (BV). We determined whether TLR variants are associated with fastidious BV-associated microbes that are linked with infertility following pelvic inflammatory disease (PID). METHOD OF STUDY: Sneathia spp., Atopobium vaginae, BVAB1, and Ureaplasma urealyticum were measured in 250 women from the PID Evaluation and Clinical Health (PEACH) study. Relative risk (RR) and 95% confidence intervals (CI) were calculated adjusting for chlamydia and gonorrhea...
December 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29262380/vitamin-d-effects-on-human-reproduction-pregnancy-and-fetal-well-being
#13
REVIEW
E L Heyden, S J Wimalawansa
Pregnancy places exceptional demands on vitamin D and calcium availability; thus, their deficiencies during pregnancy threaten the woman and her fetus. Globally, vitamin D and other micronutrient deficiencies are common during pregnancy, especially in developing countries where pregnant women have less access to supplements. Vitamin D deficiency has been reported to be as high as 40% among pregnant women. As a pregnancy progresses, the requirements for vitamin D increase and can worsen preexisting hypovitaminosis D...
December 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29259388/genital-tract-infections-in-an-isolated-community-100-women-of-the-pr%C3%A3-ncipe-island
#14
Pedro Vieira-Baptista, Svitrigaile Grinceviciene, Gert Bellen, Carlos Sousa, Conceição Saldanha, Davy Vanden Broeck, John-Paul Bogers, Gilbert Donders
Objective: To characterize the vaginal microbiome and the rate of sexually transmitted infections (STIs) in the women of Príncipe (São Tomé and Príncipe). Methods: Cross-sectional study of 100 consecutive women, invited for a free appointment and cervical cancer screening. A vaginal slide (wet mount microscopy) and a cervical sample (ThinPrep®) (Pap test, high risk human papillomavirus [HR-HPV], N. gonorrhea [NG], T. vaginalis [TV], and C. trachomatis [CT]) were obtained...
2017: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29242550/diversity-of-vaginal-microbiota-increases-by-the-time-of-labor-onset
#15
Ekaterina Avershina, Silje Slangsvold, Melanie Rae Simpson, Ola Storrø, Roar Johnsen, Torbjørn Øien, Knut Rudi
Vaginal microbiota is an important early source of bacterial colonization for newborns. However, only a few small studies have investigated the composition of vaginal microbiota during labor. In this work, we analyzed vaginal swabs collected at 36 weeks gestation and at the onset of labor from 256 women participating in a randomized placebo-controlled study of probiotic supplementation for the prevention of atopic dermatitis in offspring. Although individuals' vaginal microbiota was stable over time, several bacterial families, which are characteristic of mixed community state type (CST) IV, were overrepresented in vaginal swabs sampled at labor...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29239072/redox-imbalance-correlates-with-high-nugent-score-in-bacterial-vaginosis
#16
Shakeel Waqqar, Salman Aziz, Rabia Shakeel, Anum Waheed, Syed S Ahmed, Asad Ali, Ayyaz A Khan, Muhammad Shoaib
AIM: The main goal of this work was to highlight the significance of redox imbalance in the pathophysiology of bacterial vaginosis (BV). We studied the pro-oxidant (malondialdehyde) and antioxidants (glutathione, total antioxidant capacity) in the vaginal fluids of women and compared them on the basis of their Nugent score (NS). METHODS: Women were clinically screened using Amsel criteria (≥2 were regarded as positive) and were further screened for NS on the basis of microscopic examination...
December 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29234210/pharmaceutical-approval-update
#17
Michele B Kaufman
Secnidazole (Solosec) for the one-dose treatment of bacterial vaginosis; triamcinolone acetonide extended-release injection (Zilretta) for osteoarthritis knee pain; and insulin aspart injection (Fiasp), a rapidacting human insulin analogue for glycemic control in diabetes mellitus.
December 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29223972/intravaginal-boric-acid-is-it-an-alternative-therapeutic-option-for-vaginal-trichomoniasis
#18
Nicola Thorley, Jonathan Ross
OBJECTIVES: Trichomoniasis, caused by Trichomonas vaginalis (TV), is the most common curable sexually transmitted infection worldwide. Current guidance in the UK is to treat TV with a nitroimidazole antibiotic. The high prevalence of TV, high rate of antibiotic resistance and limited tolerability to nitroimidazoles suggest that alternative treatment regimens are needed. Intravaginal boric acid (BA) has been used safely for the treatment of candida vulvovaginitis and bacterial vaginosis, and in vitro studies suggest BA is active against TV...
December 9, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29212588/comparisons-of-vaginal-flora-patterns-among-sexual-behaviour-groups-of-women-implications-for-the-pathogenesis-of-bacterial-vaginosis
#19
Kristin M Olson, Louis J Boohaker, Jane R Schwebke, Stella Aslibekyan, Christina A Muzny
Background: Bacterial vaginosis (BV) is the most common cause of vaginal discharge. The objective was to compare the prevalence of BV by Nugent score among African-American women who have sex with women (WSW) and women who have sex with women and men (WSWM) compared with an age-matched group of women who have sex with men (WSM). Secondary objectives were to correlate low versus high Nugent scores with vaginal symptoms among women with BV and to correlate BV diagnosis with sexual practices. Methods: A secondary analysis of clinical and laboratory data from African-American WSW (n=73) and WSWM (n=68) participating in the Women's Sexual Health Project (August 2011-October 2013) and a 3:1 age-matched group of African-American WSM participating in the Longitudinal Study of Vaginal Flora (August 1999-February 2002) at a sexually transmissible infection clinic (n=423) was performed...
December 7, 2017: Sexual Health
https://www.readbyqxmd.com/read/29204281/-lactobacillus-raoultii-sp-nov-a-new-bacterium-isolated-from-the-vaginal-flora-of-a-woman-with-bacterial-vaginosis
#20
B Nicaise, M Bilen, F Cadoret, F Bretelle, F Fenollar
We report the isolation of a new bacterium species, 'Lactobacillus raoultii' strain Marseille P4006 (CSUR P4006), isolated from a vaginal sample of a 45-year-old woman with bacterial vaginosis.
January 2018: New Microbes and New Infections
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