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https://www.readbyqxmd.com/read/28523328/duodenal-gastrointestinal-stromal-tumor-presenting-as-pancreatic-head-mass-a-case-report
#1
DănuŢ Vasile, George Iancu, Raluca Claudia Iancu, George Simion, Radu Constantin Ciuluvică
Duodenal gastrointestinal stromal tumors (GISTs) are uncommon. Tumors arising from the first and the second part of the duodenum (DI and DII, respectively) can be wrongly diagnosed as pancreatic mass. We present a case of a 59-year-old woman who came with abdominal pain and severe upper gastrointestinal bleeding (hemoglobin 3.5 g÷dL). A solid, heterogeneously enhancing neoplasm in the head of the pancreas was revealed preoperatively by an abdominal computed tomography scan. A diagnosis of GIST was suggested...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28520182/intraductal-papillary-neoplasm-of-the-bile-duct-a-rare-liver-tumor-complicated-by-malignancy
#2
Kentaro Tominaga, Kenya Kamimura, Akira Sakamaki, Shuji Terai
No abstract text is available yet for this article.
May 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28506055/clinical-features-and-outcomes-of-patients-with-hepatocellular-carcinoma-complicated-with-bile-duct-invasion
#3
Jihyun An, Kwang Sun Lee, Kang Mo Kim, Do Hyun Park, Sang Soo Lee, Danbi Lee, Ju Hyun Shim, Young-Suk Lim, Han Chu Lee, Young-Hwa Chung, Yung Sang Lee
Background/Aims: Little is known about the treatment or outcomes of hepatocellular carcinoma (HCC) complicated with bile duct invasion. Methods: A total of 247 consecutive HCC patients with bile duct invasion at initial diagnosis were retrospectively included. Results: The majority of patients had Barcelona Clinic Liver Cancer (BCLC) stage C HCC (66.8%). Portal vein tumor thrombosis was present in 166 (67.2%) patients. Median survival was 4...
May 16, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28498280/immunohistochemical-characterization-of-the-origins-of-metastatic-well-differentiated-neuroendocrine-tumors-to-the-liver
#4
Zhaohai Yang, David S Klimstra, Ralph H Hruban, Laura H Tang
Metastatic neoplasms of unknown primary site pose a major challenge to patient management. As targeted therapies are now being tailored to neuroendocrine tumors (NETs) of different primary sites, identifying the origin of metastatic NETs has become increasingly important. Compared with more extensive efforts on metastatic adenocarcinomas of unknown primary, the literature on metastatic NETs (often to the liver) is relatively sparse and most studies are based on primary tumors. We sought to study metastatic well-differentiated NETs to the liver to identify markers that predict the site of origin...
May 11, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28485658/multicystic-biliary-hamartoma-with-extremely-elevated-ca19-9-a-case-report
#5
Takeshi Morinaga, Imai Katsunori, Yo-Ichi Yamashita, Takanobu Yamao, Takayoshi Kaida, Shigeki Nakagawa, Daisuke Hashimoto, Akira Chikamoto, Shinji Sumiyoshi, Yoshiki Mikami, Hideo Baba
Multicystic biliary hamartoma (MCBH) is a rare cystic disease of the liver. We herein report a case of MCBH associated with extremely elevated levels of serum carbohydrate antigen (CA) 19-9. A 53-year-old man was referred to our hospital because of extremely elevated CA19-9 levels (more than 12,000 U/mL). Enhanced abdominal computed tomography and magnetic resonance imaging (MRI) revealed a multicystic tumor with a calcified wall in the left lobe of the liver, although no apparent intracystic nodule was detected...
May 9, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28480068/biliary-cancer-intrahepatic-cholangiocarcinoma-vs-extrahepatic-cholangiocarcinoma-vs-gallbladder-cancers-classification-and-therapeutic-implications
#6
REVIEW
Daniel H Ahn, Tanios Bekaii-Saab
Biliary cancers (BCs) are a diverse group of tumors that arise from the bile duct epithelium and are divided into cholangiocarcinomas of the intrahepatic and extrahepatic cholangiocarcinoma (EHCC) and cancer of the gallbladder. Despite improvements in treatment and diagnosis, BCs are often diagnosed at an advanced stage and associated with poor prognosis and limited treatment options. Recent discoveries have allowed us to have a better understanding of the genomic diversity in BC, and identify genes that are likely contributing to its pathogenesis, proliferation and treatment resistance...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28479376/extracellular-vesicles-in-bile-as-markers-of-malignant-biliary-stenoses
#7
Valeria Severino, Jean-Marc Dumonceau, Myriam Delhaye, Solange Moll, Isabelle Annessi-Ramseyer, Xavier Robin, Jean-Louis Frossard, Annarita Farina
BACKGROUND & AIMS: Algorithms for diagnosis of malignant common bile duct (CBD) stenoses are complex and lack accuracy. Malignant tumors secrete large numbers of extracellular vesicles (EVs) into surrounding fluids; EVs might therefore serve as biomarkers for diagnosis. We investigated whether concentrations of EVs in bile could discriminate malignant from nonmalignant CBD stenoses. METHODS: We collected bile and blood samples from 50 patients undergoing therapeutic endoscopic retrograde cholangiopancreatography at university hospitals in Europe for CBD stenosis of malignant (pancreatic cancer, n=20 or cholangiocarcinoma, n=5) or nonmalignant (chronic pancreatitis [CP], n=15) origin...
May 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28472122/prognosis-of-hepatocellular-carcinoma-patients-with-bile-duct-tumor-thrombus-after-hepatic-resection-or-liver-transplantation-in-asian-populations-a-meta-analysis
#8
Chenglin Wang, Yu Yang, Donglin Sun, Yong Jiang
BACKGROUND: Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) in the clinic is rare, and surgical treatment is currently considered the most effective treatment. However, the influence of BDTT on the prognosis of HCC patients who underwent surgery remains controversial in previous studies. Therefore, this paper uses meta-analysis method to elucidate this controversy. METHODS: In this study, we conducted a literature search on databases PubMed, Embase and Web of Science from inception until September 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28470400/comparative-radiological-pathological-study-of-biliary-intraductal-tubulopapillary-neoplasm-and-biliary-intraductal-papillary-mucinous-neoplasm
#9
Chia-Hung Wu, Yi-Chen Yeh, Yu-Chuan Tsuei, Li-Kuo Huang, Chia-I Lin, Chien-An Liu, Hsiou-Shan Tseng, Yi-You Chiou, Nai-Chi Chiu
PURPOSE: Biliary tract intraductal tubulopapillary neoplasms (BT-ITPNs) and intraductal papillary mucinous neoplasms (BT-IPMNs) are rare and poorly described. Herein, we examined the magnetic resonance imaging (MRI) features of BT-ITPNs and BT-IPMNs and correlated them with key gross and microscopic pathological findings. METHODS: We retrospectively identified five patients with definitive pathological findings of BT-ITPN and available diagnostic MRI findings. Key MRI features were correlated to the gross and microscopic pathology and compared to those of BT-IPMNs (19 patients)...
May 3, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28461144/disease-free-survival-following-resection-in-non-ductal-periampullary-cancers-a-retrospective-multicenter-analysis
#10
Stéphane Bourgouin, Jacques Ewald, Julien Mancini, Vincent Moutardier, Jean-Robert Delpero, Yves-Patrice Le Treut
BACKGROUND: Predictors of recurrence following pancreaticoduodenectomy are well described for ductal periampullary cancers but lack reliability for non-ductal tumors. The purpose of this study is to analyze the disease-free survival (DFS) and to define the predictors of recurrence following resection for ampullary (AC), bile duct (BDC) and duodenal cancers (DC). MATERIALS AND METHODS: Clinico-pathological data of patients operated on between 2001 and 2011 were retrospectively reviewed...
April 28, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28454463/reduced-ebp50-expression-levels-are-correlated-with-unfavorable-clinicopathological-features-of-extrahepatic-bile-duct-carcinoma-and-promote-the-proliferation-and-migration-of-qbc939-cells
#11
Duiping Feng, Ying Xiong, Zhiqiang Peng, Qiang Ma, Tao Tao, Hua Liu, Jianfang Liang, Zhigang Wei, Junfang Zheng, Lei Wang, Hui Zhang
The present study aimed to clarify the association between ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) expression level and the tumor phenotype and clinicopathological features of extrahepatic bile duct carcinoma. Tissue samples from patients with extrahepatic bile duct carcinoma (54 cases) and patients with normal bile duct epithelia from gallbladder of cholecystitis (20 cases) were collected, and immunohistochemical staining was used to detect the expression levels of EBP50 in these tissues. In addition, small interfering (si)RNA-EBP50 was used to knock down the expression of EBP50 in the QBC939 human cholangiocarcinoma (CC) cell line...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454273/repurposing-cimetidine-for-cholangiocarcinoma-antitumor-effects-in-vitro-and-in-vivo
#12
Paweena Dana, Kulthida Vaeteewoottacharn, Ryusho Kariya, Kouki Matsuda, Sopit Wongkham, Seiji Okada
Cimetidine is a histamine type-2 (H2) receptor antagonist that has been demonstrated to have antitumor effects on various types of malignancy. However, its effect on cholangiocarcinoma (CCA), a chemotherapy-resistant bile duct tumor, has yet to be investigated. In the present study, the antitumor activity of cimetidine in vitro and in vivo was evaluated. A methylthiotetrazole assay revealed that the proliferation of certain CCA cell lines was inhibited by cimetidine, which induced the caspase-dependent apoptosis of CCA cells via suppression of the protein kinase B signaling pathway...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451831/enhancing-the-therapeutic-range-of-a-targeted-small-molecule-tubulysin-conjugate-for-folate-receptor-based-cancer-therapy
#13
Christopher P Leamon, Joseph A Reddy, Iontcho R Vlahov, Ryan Dorton, Alicia Bloomfield, Marilynn Vetzel, Patrick J Klein, Elaine Westrick, Le-Cun Xu, Yu Wang
PURPOSE: EC0305 represents a folate-tubulysin B construct capable of specifically eradicating folate receptor (FR)-positive subcutaneous tumors from mice (Leamon et al., Cancer Res 68:9839-9844, 8). Herein we report on the use of multiple polar carbohydrate segments (e.g. 1-amino-1-deoxy-glucitolyl-γ-glutamate) placed in-between the folate and tubulysin B moieties of EC0305 creating a new conjugate, herein referred to as EC0531, with more desirable biological properties. METHODS: The synthesis of EC0531 and its tritium-labeled counterpart are described...
June 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28451405/biliary-intraductal-papillary-neoplasm-with-metachronous-multiple-tumors-true-multicentric-tumors-or-intrabiliary-dissemination-a-case-report-and-review-of-the-literature
#14
Masataka Yokode, Yukimasa Yamashita, Yoh Zen
Intraductal papillary neoplasms of the bile duct (IPNBs) are recognized as a distinct type of biliary tumor. We herein discuss the possible mechanisms underlying the development of multiple tumors in patients with IPNBs through a case presentation and literature review. A 64-year-old woman initially underwent extended right hepatectomy for IPNB in the right hepatic duct. Although the surgical margin of the common bile duct was tumor-free, recurrence was detected in the intrapancreatic bile duct 26 months later...
March 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28445298/barcelona-clinic-liver-cancer-stage-c-hepatocellular-carcinoma-a-novel-approach-to-subclassification-and-treatment
#15
Chung Hwan Jun, Jae Hyun Yoon, Eunae Cho, Sang Soo Shin, Sung Bum Cho, Hee Joon Kim, Chang Hwan Park, Hyun Soon Kim, Sung Kyu Choi, Jong Sun Rew
Barcelona clinic liver cancer-stage C (BCLC-C) encompasses a broad spectrum of tumor burdens, liver function statuses, patient prognoses, and treatment strategies. Currently, sorafenib is the only recommended treatment for patients with BCLC-C and outcomes remain suboptimal. The aims of this study were to assess the heterogeneity of BCLC-C hepatocellular carcinoma (HCC) cases, propose a novel subclassification for these cases, and suggest optimal treatment strategies other than sorafenib.We retrospectively analyzed 196 consecutive BCLC-C HCC patients who were diagnosed and treated between January 2008 and December 2015...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28440243/a-case-of-biliary-fascioliasis-mimicking-a-common-bile-duct-tumor-with-video
#16
Hyung Ku Chon, Tae Hyeon Kim
No abstract text is available yet for this article.
March 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28439733/duodenal-involvement-is-an-independent-prognostic-factor-for-patients-with-surgically-resected-pancreatic-ductal-adenocarcinoma
#17
Marco Dal Molin, Amanda L Blackford, Abdulrehman Siddiqui, Aaron Brant, Christy Cho, Neda Rezaee, Jun Yu, Jin He, Matthew Weiss, Ralph H Hruban, Christopher Wolfgang, Michael Goggins
BACKGROUND: The current staging system for pancreatic ductal adenocarcinoma (PDAC) includes information about size and local extension of the primary tumor (T stage). The value of incorporating any local tumor extension into pancreatic staging systems has been questioned because it often is difficult to evaluate tumor extension to the peri-pancreatic soft tissues and because most carcinomas of the head of the pancreas infiltrate the intra-pancreatic common bile duct. This study sought to evaluate the prognostic implications of having PDAC with local tumor extension...
April 24, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28431889/clinicopathologic-radiologic-and-molecular-study-of-23-combined-hepatocellular-cholangiocarcinomas-with-stem-cell-features-cholangiolocellular-type
#18
Jun Chen, Jian He, Min Deng, Hong-Yan Wu, Jiong Shi, Liang Mao, Qi Sun, Min Tang, Xiang-Shan Fan, Yu-Dong Qiu, Qin Huang
Cholangiolocellular carcinoma is a type of intrahepatic cholangiocarcinoma (ICC). According to the 2010 World Health Organization classification, this carcinoma is a combined hepatocellular-cholangiocarcinoma with stem cell features, cholangiolocellular type (CHC-SC-CLC). The aim of this study was to compare the clinicopathologic characteristics of CHC-SC-CLC and conventional ICC. Based on the gross and histologic characteristics, we divided consecutive ICC tumors into CHC-SC-CLC (n = 23), mass-forming (MF, n = 57), and non-MF (n = 22) groups...
April 18, 2017: Human Pathology
https://www.readbyqxmd.com/read/28425663/management-of-acute-cholangitis-as-a-result-of-occlusion-from-a-self-expandable-metallic-stent-in-patients-with-malignant-distal-and-hilar-biliary-obstructions
#19
Hideyuki Shiomi, Kazuya Matsumoto, Hiroyuki Isayama
Acute cholangitis as a result of common bile duct stones can be managed; however, cholangitis caused by occlusion with a biliary self-expandable metallic stent (SEMS) in patients with an unresectable malignant biliary obstruction has not been fully discussed. The acute cholangitis clinical guidelines (Tokyo Guidelines 2013) recommend following the same procedure as that used for cholangitis; however, the patient's condition, including performance status, tumor extension or staging, and prognosis must be considered...
April 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28423673/ceruloplasmin-as-a-prognostic-marker-in-patients-with-bile-duct-cancer
#20
In Woong Han, Jin-Young Jang, Wooil Kwon, Taesung Park, Yongkang Kim, Kyoung Bun Lee, Sun-Whe Kim
BACKGROUND AND AIMS: Bile duct cancer is one of the lethal cancers, presenting difficulties in early diagnosis and limited treatment modalities. Despite current advances in biomarker research, most studies have been performed in Western populations. Therefore, the purpose of this study was to determine a prognostic marker for bile duct cancer, especially in Korean patients, whose incidence of bile duct cancer is high. RESULTS: Comparing cancer and normal bile duct tissue, we identified 29091 differentially expressed genes...
April 25, 2017: Oncotarget
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