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Pancreaticobiliary carcinoma

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https://www.readbyqxmd.com/read/27704265/biliary-carcinogenesis-in-pancreaticobiliary-maljunction
#1
Terumi Kamisawa, Sawako Kuruma, Kazuro Chiba, Taku Tabata, Satomi Koizumi, Masataka Kikuyama
Pancreaticobiliary maljunction (PBM) is a congenital malformation in which the pancreatic and bile ducts join anatomically outside the duodenal wall. Because of the excessive length of the common channel in PBM, sphincter action does not directly affect the pancreaticobiliary junction, which allows pancreatic juice to reflux into the biliary tract. According to the results of a nationwide survey, bile duct and gallbladder cancers were found in 6.9 and 13.4 % of adult patients with congenital biliary dilatation, respectively, and in 3...
October 4, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27616039/pancreas-divisum-a-risk-factor-for-pancreaticobiliary-tumors%C3%A2-%C3%A2-an-analysis-of-1628-mr-cholangiography-examinations
#2
Z H Adibelli, M Adatepe, L Isayeva, O S Esen, M Yildirim
PURPOSE: This retrospective study was conducted to evaluate the relationships between pancreas divisum, biliary duct anatomical variations and pancreaticobiliary tumors using magnetic resonance cholangiopancreatography (MRCP). MATERIALS AND METHOD: The MRCP examinations of 1628 patients were retrospectively reviewed for the presence of pancreas divisum, biliary duct anatomical variations and pancreaticobiliary tumors. Of these, 90 patients (31 men, 59 women) with a mean age of 62...
September 5, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27034817/non-pancreatic-retroperitoneal-mucinous-neoplasms-and-a-discussion-of-the-differential-diagnosis
#3
Summer E Blount, Camilla Cobb, Anwar Sultana Raza
Retroperitoneal mucinous neoplasms are common and have a wide range of differential diagnoses to consider. It is of utmost importance to maintain a multidisciplinary approach when evaluating these lesions. Clinical history, surgical impression and radiographic studies should be obtained and used in conjunction with morphology and immunohistochemistry to help guide the pathologist to the correct diagnosis. We recently encountered a case of a 51-year-old man who presented with an 11.5 cm left-sided retroperitoneal mucinous neoplasm...
April 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/26892153/morphologic-immunophenotypic-and-molecular-features-of-epithelial-ovarian-cancer
#4
REVIEW
Preetha Ramalingam
Epithelial ovarian cancer comprises a heterogeneous group of tumors. The four most common subtypes are serous, endometrioid, clear cell, and mucinous carcinoma. Less common are transitional cell tumors, including transitional cell carcinoma and malignant Brenner tumor. While in the past these subtypes were grouped together and designated as epithelial ovarian tumors, these tumor types are now known to be separate entities with distinct clinical and biologic behaviors. From a therapeutic standpoint, current regimens employ standard chemotherapy based on stage and grade rather than histotype...
February 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/26685087/a-detailed-immunohistochemical-analysis-of-a-large-series-of-cervical-and-vaginal-gastric-type-adenocarcinomas
#5
MULTICENTER STUDY
Claire Carleton, Lien Hoang, Shatrughan Sah, Takako Kiyokawa, Yevgeniy S Karamurzin, Karen L Talia, Kay J Park, W Glenn McCluggage
Adenocarcinomas exhibiting gastric differentiation represent a recently described and uncommon subtype of non-human papillomavirus (HPV)-related cervical adenocarcinoma. They comprise a spectrum from a well-differentiated variant (adenoma malignum/mucinous variant of minimal deviation adenocarcinoma) to a more poorly differentiated overtly malignant form, generally referred to as gastric-type adenocarcinoma. Rarely, such tumors have also been described as primary vaginal neoplasms. Gastric-type adenocarcinomas exhibit considerable morphologic overlap with adenocarcinomas originating outside the female genital tract, especially mucinous adenocarcinomas arising in the pancreas and biliary tract...
May 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26611763/intraductal-papillary-mucinous-neoplasm-involving-pancreaticobiliary-maljunction-and-an-aberrant-pancreatic-duct-draining-into-the-stomach-a-case-report-and-review-of-the-literature
#6
REVIEW
Yuko Kinowaki, Yutaka Takazawa, Noriko Yamamoto, Yuichi Ishikawa
Intraductal papillary mucinous neoplasms (IPMN) are characterized by the growth of epithelial components with mucin production in the main pancreatic duct, or a large branch. We report a case of intraductal papillary mucinous carcinoma (IPMC) of the pancreatic head, complicated by pancreaticobiliary maljunction (PBM) and an aberrant pancreatic duct draining into the stomach. A 50-year-old man with malaise and jaundice was found to have a mass in the pancreatic head at a local hospital. He was clinically diagnosed with IPMC with invasion to the stomach and duodenum after extensive endoscopic and radiological evaluation and a pancreaticoduodenectomy was performed...
February 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/26604631/gallbladder-carcinoma-prognostic-factors-and-therapeutic-options
#7
REVIEW
Thorsten Oliver Goetze
The outcome of gallbladder carcinoma is poor, and the overall 5-year survival rate is less than 5%. In early-stage disease, a 5-year survival rate up to 75% can be achieved if stage-adjusted therapy is performed. There is wide geographic variability in the frequency of gallbladder carcinoma, which can only be explained by an interaction between genetic factors and their alteration. Gallstones and chronic cholecystitis are important risk factors in the formation of gallbladder malignancies. Factors such as chronic bacterial infection, primary sclerosing cholangitis, an anomalous junction of the pancreaticobiliary duct, and several types of gallbladder polyps are associated with a higher risk of gallbladder cancer...
November 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26465278/-the-role-of-metabolic-syndrome-in-gastroenterology
#8
Petr Dítě, Jitka Přinosilová, Lenka Dovrtělová, Tomáš Kupka, Hana Nechutová, Bohuslav Kianička, Bohdana Břegová, Lumír Kunovský, Arnošt Martínek, Miroslav Souček
GOAL: Metabolic syndrome and its components play an important part in the development of not only cardiovascular conditions, but also digestive and pancreaticobiliary system diseases. The aim of our study is to present a comprehensive overview of the diseases where metabolic syndrome is an inducing risk factor, or where it affects the course of the disease. RESULTS: Metabolic syndrome is a significant risk factor of induction of gastroesophageal reflux and its complication, which is Barretts esophagus...
September 2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26223666/-papillary-tumors-therapeutic-concepts
#9
REVIEW
F C Popp, J Weigt, T Kalinski, C Betzler, J Arend, B Garlipp, C Benckert, C J Bruns
Papillary tumors originate from the various structures of the ampulla of Vater; therefore, these rare tumors represent a heterogeneous group of tumor entities. Intestinal differentiated adenomas are the most common benign lesions, whereas intestinal differentiated papillary carcinomas are the most common malignant tumors. Carcinomas with pancreaticobiliary differentiation have a poorer prognosis. Mesenchymal and neuroendocrine tumors are among the least frequent papillary tumors. Diagnosis is performed by side-view upper endoscopy and biopsy...
August 2015: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/26165737/long-term-risk-for-acute-pancreatitis-cholangitis-and-malignancy-more-than-15-years-after-endoscopic-sphincterotomy-a-population-based-study
#10
COMPARATIVE STUDY
Ann Langerth, Gabriel Sandblom, Britt-Marie Karlson
BACKGROUND AND STUDY AIMS: It has been suggested that endoscopic sphincterotomy predisposes a patient to cholangitis, pancreatitis, and carcinoma in the pancreaticobiliary tract in the long term. Previous studies have shown an increased risk for acute cholangitis and pancreatitis but not for carcinoma. The aim of this study was to analyze these risks by conducting a long-term follow-up study of patients who underwent treatment for gallstone disease, comparing patients who underwent endoscopic sphincterotomy with those who did not...
December 2015: Endoscopy
https://www.readbyqxmd.com/read/26063033/endoscopic-ultrasound-guided-fine-needle-aspiration-cytology-in-pancreaticobiliary-carcinomas-diagnostic-efficacy-of-cell-block-immunocytochemistry
#11
COMPARATIVE STUDY
Antonio Ieni, Paolo Todaro, Stefano Francesco Crino, Valeria Barresi, Giovanni Tuccari
BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration cytology was demonstrated to be a useful tool for the diagnosis and staging of pancreaticobiliary neoplastic lesions. Nonetheless, the diagnostic value of this procedure may be limited by low cellularity of the specimen, contamination of intestinal cells and unfeasibility of ancillary immunocytochemical procedures. The present study was to evaluate its usefulness in the diagnosis of neoplastic lesions. METHODS: A series of 46 pancreaticobiliary carcinomas with available cell block preparations was submitted to immunocytochemistry against cytokeratins, carcinoembryonic antigen, E-cadherin, CD10 and p53...
June 2015: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/25975284/sequencing-of-279-cancer-genes-in-ampullary-carcinoma-reveals-trends-relating-to-histologic-subtypes-and-frequent-amplification-and-overexpression-of-erbb2-her2
#12
Jaclyn F Hechtman, Weiguo Liu, Justyna Sadowska, Lisa Zhen, Laetitia Borsu, Maria E Arcila, Helen H Won, Ronak H Shah, Michael F Berger, Efsevia Vakiani, Jinru Shia, David S Klimstra
The biological relevance of histological subtyping of ampullary carcinoma into intestinal vs pancreaticobiliary types remains to be determined. In an effort to molecularly profile these subtypes of ampullary carcinomas, we conducted a two-phase study. In the discovery phase, we identified 18 pancreatobiliary-type ampullary carcinomas and 14 intestinal-type ampullary carcinomas using stringent pathologic criteria and performed next-generation sequencing targeting 279 cancer-associated genes on these tumors. Although the results showed overlapping of genomic alterations between the two subtypes, trends including more frequent KRAS alterations in pancreatobiliary-type ampullary carcinoma (61 vs 29%) and more frequent mutations in APC in intestinal-type ampullary carcinoma (43 vs 17%) were observed...
August 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/25800066/a-phase-ii-study-of-adjuvant-gemcitabine-plus-docetaxel-followed-by-concurrent-chemoradation-in-resected-pancreaticobiliary-carcinoma
#13
May Cho, Andrea Wang-Gillam, Robert Myerson, Feng Gao, Steven Strasberg, Joel Picus, Steven Sorscher, Chloe Fournier, Gayathri Nagaraj, Parag Parikh, Rama Suresh, David Linehan, Benjamin R Tan
OBJECTIVES: Adjuvant gemcitabine with or without chemoradiation is a standard therapeutic option for patients with resected pancreatic cancer. The feasibility and toxicity of gemcitabine with docetaxel before and after 5-fluorouracil (5FU)-based chemoradiation in the adjuvant pancreatic and biliary cancer setting were investigated. METHODS: After a curative-intent resection, eligible patients with pancreaticobiliary cancers were treated with two cycles of gemcitabine and docetaxel followed by 5FU-based chemoradiation...
July 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/25487540/kras-mutation-testing-in-clinical-practice
#14
REVIEW
Sudhir Perincheri, Pei Hui
Activating mutation of KRAS plays a significant role in the pathogenesis of common human malignancies and molecular testing of KRAS mutation has emerged as an essential biomarker in the current practice of clinical oncology. The presence of KRAS mutation is generally associated with clinical aggressiveness of the cancer and reduced survival of the patient. Therapeutically, KRAS mutation testing has maximum utility in stratifying metastatic colorectal carcinoma and lung cancer patients for treatment with targeted therapy...
March 2015: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/25416002/primary-biliary-tract-malignancies-mri-spectrum-and-mimics-with-histopathological-correlation
#15
REVIEW
Pardeep K Mittal, Courtney Coursey Moreno, Bobby Kalb, Ankush Mittal, Juan C Camacho, Kiran Maddu, Hiroumi D Kitajima, Brian C Quigley, Nima Kokabi, William C Small
Contrast-enhanced magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP), due to their excellent soft tissue contrasts, have become first-line noninvasive tests in the characterization and detection of both hepatic and pancreaticobiliary pathologies. MRCP is also helpful in detecting the level and cause of obstruction in patients presenting with jaundice. Cholangiocarcinoma (CCA) is the most common primary malignant tumor arising from the bile duct epithelium, with extrahepatic tumors presenting more often than with intrahepatic ones...
August 2015: Abdominal Imaging
https://www.readbyqxmd.com/read/25188110/hepatobiliary-pancreas-pathology-sy11-4-cytohistology-of-focal-liver-lesions-with-glandular-features-approach-and-pitfalls
#16
Aileen Wee
Focal liver lesions with glandular features encompass inflammatory, hyperplastic, hamartomatous to neoplastic lesions. They can be solid/cystic, solitary/multiple, occurring in a normal/diseased liver. Hepatobiliary entities should be segregated before considering nonhepatobiliary conditions.In small tissue samples such as fine needle aspiration (FNA) or core biopsy, the diagnostic issues are to distinguish/recognize cystic from solid lesions, primary from metastatic adenocarcinoma, poorly differentiated adenocarcinoma from poorly differentiated hepatocellular carcinoma (HCC), rare glandular entities, mimics and pitfalls...
October 2014: Pathology
https://www.readbyqxmd.com/read/25146100/a-case-of-mixed-adenoneuroendocrine-carcinoma-of-the-gallbladder-arising-from-an-intracystic-papillary-neoplasm-associated-with-pancreaticobiliary-maljunction
#17
Yoshiyuki Meguro, Noriyoshi Fukushima, Masaru Koizumi, Naoya Kasahara, Masanobu Hydo, Kazue Morishima, Naohiro Sata, Alan T Lefor, Yoshikazu Yasuda
A 54-year-old Japanese woman was referred with a gallbladder tumor. Based on the results of the computed tomography scan, endoscopic retrograde cholangiopancreatography, and magnetic resonance cholangiopancreatography, a mucin-producing neoplasm of the gallbladder associated with pancreaticobiliary maljunction was diagnosed. Extended cholecystectomy, extrahepatic bile duct resection, and choledochojejunostomy were performed, and she remains free of recurrence 24 months after resection. Histopathological examination revealed that the papillary component of the lesion was an intracystic papillary neoplasm with diverse characteristics of pancreaticobiliary epithelium and intestinal epithelium including mucin...
September 2014: Pathology International
https://www.readbyqxmd.com/read/24713843/predictors-of-long-term-survival-following-resection-for-ampullary-carcinoma-a-large-retrospective-french-multicentric-study
#18
Pierre-Emmanuel Robert, Christophe Leux, Mehdi Ouaissi, Mathieu Miguet, François Paye, Aude Merdrignac, Jean Robert Delpero, Lilian Schwarz, Nicolas Carrere, Fabrice Muscari, Brice Gayet, David Dussart, Antoine Hamy, Nicolas Regenet
OBJECTIVES: Ampullary carcinoma is a rare tumor. There are neither sufficient available data related to management after resection of the neoplasm of the ampulla of Vater, nor any international recommendations. The aim of this study was to identify factors associated with recurrence and survival after curative resection. METHODS: A retrospective follow-up study was conducted including patients with ampullary carcinoma who underwent resection with curative intent in 12 French surgical centers between January 1990 and November 2011...
July 2014: Pancreas
https://www.readbyqxmd.com/read/24705640/double-duct-sign-in-the-era-of-endoscopic-ultrasound-the-prevalence-of-occult-pancreaticobiliary-malignancy
#19
Jonah Cohen, Mandeep S Sawhney, Douglas K Pleskow, Ram Chuttani, Nirav J Patel, Jennifer Sheridan, Tyler M Berzin
BACKGROUND AND AIM: Simultaneous dilatation of the common bile duct and pancreatic duct, "double-duct sign" (DDS), is an ominous finding concerning for pancreaticobiliary malignancy. Little evidence exists to guide the initial evaluation and subsequent follow-up for patients with DDS in the absence of jaundice or focal mass noted on computed tomography (CT)/ magnetic resonance imaging (MRI). Endoscopic ultrasound (EUS) is often recommended in the evaluation of such patients, however, the prevalence of malignancy remains unclear...
September 2014: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/24625417/adenocarcinoma-of-the-minor-duodenal-papilla-and-its-precursor-lesions-a-clinical-and-pathologic-study
#20
Jinru Shia, Narasimhan P Agaram, Semra Olgac, Brando Cobanov, Volkan Adsay, David S Klimstra
The minor duodenal papilla drains the accessory pancreatic duct of Santorini and lies proximal to the ampulla of Vater. Adenocarcinoma and its precursor lesions arising in the minor papilla are rare. Literature data thus far are limited to a few individual case reports, and the condition is consequently poorly defined. Our study cases were composed of carcinomas fulfilling all of the following criteria: location at 1.5 to 2.5 cm proximal to the major papilla; presence of associated submucosal pancreatobiliary-type ducts with periductal glands or acinar tissue; a predominant submucosal location of the tumor; and lack of an intestinal-type adenoma in the adjacent duodenal mucosa...
April 2014: American Journal of Surgical Pathology
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